Kyushu University Academic Staff Educational and Research Activities Database
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Yusuke Arima Last modified date:2024.04.03

Associate Professor / Department of Chemistry, Graduate School of Sciences
Department of Fundamental Organic Chemistry
Institute for Materials Chemistry and Engineering

Graduate School

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Academic Degree
Ph.D (Engineering)
Country of degree conferring institution (Overseas)
Field of Specialization
Biomaterials, Surface chemistry
Total Priod of education and research career in the foreign country
Outline Activities
We take approaches from surface chemistry to control cellular function and to detect biomarkers.
1) Understanding of biomolecular events at the interface between artificial materials and biological systems
2) Modification of cell surface with biomolecule-conjugated amphiphilic polymers to engineer cell functions
3) Detection of biomarkers
Research Interests
  • Interfacial design of metal nanoparticles sheet for observing cell-attached nanointerface
    keyword : Metal nanoparticles, two-dimensional sheet, fluorescence microscope, surface modification, cell adhesion
  • Biosensing using placmonic colorimetric substrates
    keyword : Surface plasmon, biosensing
  • Control of cell-cell interaction using cell surface modification
    keyword : Cell surface modification, amphiphilic polymers, biomolecules
Academic Activities
1. Y. Arima, R. Ishii, I. Hirata, H. Iwata, High-throughput study of protein-surface interactions using a surface plasmon resonance imaging apparatus, American Chemical Society, 10.1021/bk-2012-1120.ch032, 2012.12.
1. Y. Arima, M. Toda, H. Iwata, Surface plasmon resonance in monitoring of complement activation on biomaterials, Adv. Drug. Deliv. Rev., 63, 988-999.
2. Y. Arima, K. Kato, Y. Teramura, H. Iwata, Design of biointerfaces for regenerative medicine, Adv. Polym. Sci., 247, 167-200.
1. Shi Ting Lee, Thasaneeya Kuboki, Satoru Kidoaki, Yukiko Aida, Sou Ryuzaki, Koichi Okamoto, Yusuke Arima, Kaoru Tamada, Transient Nascent Adhesion at the Initial Stage of Cell Adhesion Visualized on a Plasmonic Metasurface, Advanced NanoBiomed Research, 10.1002/anbr.202100100, 2, 2021.11.
2. Shihomi Masuda, Thasaneeya Kuboki, Satoru Kidoaki, Shi Ting Lee, Sou Ryuzaki, Koichi Okamoto, Yusuke Arima, Kaoru Tamada, High Axial and Lateral Resolutions on Self-Assembled Gold Nanoparticle Metasurfaces for Live-Cell Imaging, ACS Appl. Nano Mater., 3, 11, 11135-11142, 2020.10.
3. I. T. Hoffecker, Y. Arima, H. Iwata, Tuning intercellular adhesion with membrane-anchored
oligonucleotides, J. Royal Soc. Interface, 10.1098/rsif.2019.0299, 2019.10.
4. Y. Arima, Y. Teramura, H. Takiguchi, K. Kawano, H. Kotera, H. Iwata, Surface plasmon resonance and surface plasmon field-enhanced fluorescence spectroscopy for sensitive detection of tumor markers, Methods Mol. Biol., 503, 3-20.
5. Y. Arima, R. Ishii, I. Hirata, H. Iwata, Development of surface plasmon resonance imaging apparatus for high-throughput study of protein-surface interactions, e-J. Surf. Sci. Nanotech., 10.1380/ejssnt.2006.201, 4, 201-207.
6. Y. Teramura, Y. Arima, H. Iwata, Surface plasmon resonance-based highly sensitive immunosensing for brain natriuretic peptide using nanobeads for signal amplification, Anal. Biochem., 10.1016/j.ab.2006.07.032, 357, 208-215.
7. Y. Arima, H. Iwata, Effect of wettability and surface functional groups on protein adsorption and cell adhesion using well-defined mixed self-assembled monolayers, Biomaterials, 10.1016/j.biomaterials.2007.03.013, 28, 3074-3082.
8. Y. Arima, H. Iwata, Effects of surface functional groups on protein adsorption and subsequent cell adhesion using self-assembled monolayers, J. Mater. Chem., 10.1039/B708099A, 17, 4079-4087.
9. Y. Arima, M. Toda, H. Iwata, Complement activation on surfaces modified with ethylene glycol units, Biomaterials, 10.1016/j.biomaterials.2007.10.015, 29, 551-560.
10. Y. Arima, M. Kawagoe, M. Toda, H. Iwata, Complement activation by polymers carrying hydroxyl groups
, ACS Appl. Mater. Interfaces, 10.1021/am9005463, 1, 2400-2407.
11. M. Toda, Y. Arima, H. Iwata, Complement activation on degraded polyethylene glycol-covered surface, Acta Biomater., 10.1016/j.actbio.2010.01.035, 6, 2642-2649.
12. Y. Arima, M. Kawagoe, M. Furuta, M. Toda, H. Iwata, Effect of swelling of poly(vinyl alcohol) layers on complement activation, Biomaterials, 10.1016/j.biomaterials.2010.05.063, 31, 6926-6933.
13. T. Murakami, Y. Arima, M. Toda, H. Takiguchi, H. Iwata, Effect of dielectric spacer thickness on signal intensity of surface plasmon field-enhanced fluorescence spectroscopy
, Anal. Biochem., 10.1016/j.ab.2011.12.008, 421, 632-639.
14. M. Toda, Y. Arima, H. Takiguchi, H. Iwata, Surface plasmon field-enhanced fluorescence spectroscopy apparatus with a convergent optical system for point-of-care testing, Anal. Biochem., 10.1016/j.ab.2014.08.029, 467, 47-53.
15. T. Matsui, Y. Arima, N. Takemoto, H. Iwata, Cell patterning on polylactic acid through surface-tethered oligonucleotides, Acta Biomater., 10.1016/j.actbio.2014.11.011, 13, 32-41.
16. I. T. Hoffecker, N. Takemoto, Y. Arima, H. Iwata, Sequence-specific nuclease-mediated release of cells tethered by oligonucleotide phospholipids, Biomaterials, 10.1016/j.biomaterials.2015.02.059, 53, 318-329.
17. E. Y. Egawa, N. Kitamura, R. Nakai, Y. Arima, H. Iwata, A DNA hybridization system for labeling of neural stem cells with SPIO nanoparticles for MRI monitoring post-transplantation
, Biomaterials, 10.1016/j.biomaterials.2015.03.017, 54, 158-167.
18. T. Itagaki, Y. Arima, R. Kuwabara, N. Kitamura, H. Iwata, Interaction between cells and poly(ethylene glycol)-lipid conjugates, Colloid Interfaces B, 10.1016/j.colsurfb.2015.08.014, 135, 765-773.
19. Y. Arima, H. Iwata, Preferential adsorption of cell adhesive proteins from complex media on self-assembled monolayers and its effect on subsequent cell adhesion
, Acta Biomater., 10.1016/j.actbio.2015.08.033, 26, 72-81.
1. Shi Ting Lee, Thasaneeya Kuboki, Satoru Kidoaki, Yukiko Aida, Yusuke Arima, Kaoru Tamada, Gold nanoparticle sheet with high axially confined light for the interfacial fluorescence imaging for actin dynamic monitoring in breast cancer cells , The 73rd Divisional Meeting of Division of Colloid and Surface Chemistry, 2022.09.
2. Y. Arima, C. Hirai, K. Tamada , Cell-cell attachment by cell surface-anchored nucleic acids and its cell-type dependence
, The 15th International Symposium on Nanomedicine, 2022.12.
3. S. T. Lee, T. Kuboki, S. Kidoaki, Y. Aida, S. Ryuzaki, K. Okamoto, Y. Arima, K. Tamada , Plasmonic metasurface with high axial light confinement for the interfacial monitoring on actin dynamic during early cell adhesion stage
, The 22nd International Vacuum Congress, 2022.09.
4. Y. Arima, C. Hirai, R. Hagio, K. Tamada, Cell type-independent surface modification with nucleic acids for cell manipulation, The 14th International Symposium on Nanomedicine, 2021.11.
5. Shi Ting Lee, Thasaneeya Kuboki, Satoru Kidoaki, Yukiko Aida, Sou Ryuzaki, Yusuke Arima, Kaoru Tamada, Transient nascent adhesion in early cell adhesion observed by LSPR-based fluorescence imaging, The 8th Asian Biomaterials Congress, 2021.11.
6. Yuichiro Miyake, Sou Ryuzaki, Yusuke Arima, Koichi Okamoto, Kaoru Tamada, A Study of Colorimetric Biosensor by use of Plasmonic Full Color, Materials Research Meeting 2019, 2019.12.
7. Yusuke Arima, Cell-cell interaction studied using model cell membrane, The 7th China-Japan Symposium on Nanomedicine, 2019.05.
8. Yusuke Arima, Interaction at Cell-Cell Interface Studied using Model Cell Surface, 2018 Taiwan-Japan-Korea trilateral Conference on Nanomedicine, 2018.12.
9. Yusuke Arima, Cell-cell interaction studied using model cell surface, 12th International Symposium on Nanomedicine, 2018.12.
Membership in Academic Society
  • The Japan Society of Applied Physics
  • The Japanese Society for Regenerative Medicine
  • The Society of Polymer Science, Japan
  • Japanese Society for Biomaterials
Educational Activities
Nanomaterials and Interfaces II (Graduate school of Sciences)