Kyushu University Academic Staff Educational and Research Activities Database
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Saito Daisuke Last modified date:2024.06.03



Graduate School


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Homepage
https://kyushu-u.elsevierpure.com/en/persons/daisuke-saito-2
 Reseacher Profiling Tool Kyushu University Pure
Phone
092-802-4270
Fax
092-802-4270
Academic Degree
Doctor of Science
Country of degree conferring institution (Overseas)
No
Field of Specialization
Developmental Biology
ORCID(Open Researcher and Contributor ID)
0000-0002-5999-2505
Total Priod of education and research career in the foreign country
00years05months
Outline Activities
Germ cells are the sole and fundamental cells to leave offspring. Although germ cells in an animal body would be strictly regulated to avoid aberrant proliferation, cell death, and differentiation due to its biological significance, the regulatory mechanisms of germ cells have been largely unknown. To address the issues, we study the developmental mechanisms of germ cells in vertebrate embryos, focusing on the cellular and molecular interactions between germ cells and environmental somatic cells, in the contexts of germ cell maintenance and migration. We progress these researches by maximizing the advantages of avian system including in vivo high quality imaging, cell/tissue transplantation, germ cell culture, and transgenic chickens and quails. In addition to basic developmental researches, we are also interested in various applications of avian reproductive engineering.
Research
Research Interests
  • in vivo analysis of cancer cell behaviors
    keyword : cancer cell, metastasis
    2021.04~2022.03.
  • Elucidation of mechanisms of primordial germ cell regulations in vivo.
    Applications of transgenic avian technics.
    keyword : Primordial germ cell, Avian, Developmental Biology, Niche, Transgenic animal
    2019.01~2025.03.
Academic Activities
Papers
1. Daisuke Saito, Ryosuke Tadokoro, Arata Nagasaka, Daisuke Yoshino, Takayuki Teramoto, Kanta Mizumoto, Kenichi Funamoto, Hinako Kidokoro, Takaki Miyata, Koji Tamura, Yoshiko Takahashi, Stiffness of primordial germ cells is required for their extravasation in avian embryos, iScience, 10.1016/j.isci.2022.105629, 105629-105629, iScience 20, 105629, 2022.11, Unlike mammals, primordial germ cells (PGCs) in avian early embryos exploit blood circulation to translocate to the somatic gonadal primordium, but how circulating PGCs undergo extravasation remains elusive. We demonstrate with single-cell level live-imaging analyses that the PGCs are arrested at a specific site in the capillary plexus,which is predominantly governed by occlusion at a narrow path in the vasculature. The occlusion is enabled by a heightened stiffness of the PGCs mediated by actin polymerization. Following the occlusion, PGCs reset their stiffness to soften in order to squeeze through the endothelial lining as they transmigrate. Our discovery also provides a model for the understanding of metastasizing cancer extravasation occurring mainly by occlusion..
Membership in Academic Society
  • The Japanese Cancer Association
  • The Molecular Biology Society of Japan
  • 日本動物学会
  • 日本発生生物学会
Awards
  • 東北大学大学院理学研究科・青葉理学振興会賞
  • 日本発生生物学会・日本細胞生物学会合同大会・最優秀若手ポスター賞
  • 平成25年度 文部科学大臣表彰若手科学者賞
  • 奈良先端科学技術大学院大学・第10回梅園賞
  • 第20回井上研究奨励賞
Educational
Educational Activities
Cell biology.
Developmental Biology.
Molecular Developmental Biology.
Other Educational Activities
  • 2018.01.