Kyushu University Academic Staff Educational and Research Activities Database
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Hidetoshi Tsushima Last modified date:2021.06.03





Homepage
https://kyushu-u.pure.elsevier.com/en/persons/hidetoshi-tsushima
 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Philosophiae Doctor
Country of degree conferring institution (Overseas)
No
Field of Specialization
Orthopaedic Surgery
Total Priod of education and research career in the foreign country
03years01months
Research
Research Interests
  • Investigation of the mechanism of chondrocyte differentiation / Investigation of cartilage degeneration of arthritis / The diagnosis of cartilage degeneration using T1rho mapping of MRI
    keyword : chondrocyte differentiation, cartilage degeneration, arthritis, MRI
    2019.04~2024.03.
Academic Activities
Papers
1. Toya M, Akasaki Y, Sueishi T, Kurakazu I, Kuwahara M, Uchida T, Tsutsui T, Tsushima H, Yamada H, Lotz MK, Nakashima Y., G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis., Sci Rep, 18;11(1):10481, 2021.05.
2. Takakura K, Akasaki Y, Kuramoto T, Onizuka Y, Hattori A, Hamai S, Tsushima H, Kawahara S, Nakashima Y, Kato T, Angular accuracy of plain radiographic measurements in leg alignment: Teleoroentgenogram versus orthoroentgenogram.
, J Orthop Sci, 14:S0949-2658(21)00085-3, 2021.04.
3. Sakuragi T, Yamada H, Haraguchi A, Kai K, Fukushi JI, Ikemura S, Akasaki Y, Fujiwara T, Tsushima H, Tsutsui T, Kondo M, Yoshikai Y, Okada S, Nakashima Y, Autoreactivity of Peripheral Helper T Cells in the Joints of Rheumatoid Arthritis., .J Immunol, 12:ji2000783, 2021.04.
4. Fujiwara T, Tokuda K, Momii K, Shiomoto K, Tsushima H, Akasaki Y, Ikemura S, Fukushi JI, Maki J, Kaku N, Akahoshi T, Taguchi T, Nakashima Y, Prognostic factors for the short-term mortality of patients with rheumatoid arthritis admitted to intensive care units., BMC Rheumatol, 4;4(1):64, 2020.12.
5. Kawahara S, Mawatari T, Matsui G, Mizu-Uchi H, Hamai S, Akasaki Y, Tsushima H, Nakashima Y., Malrotation of whole-leg radiograph less than 10 degrees does not influence preoperative planning in open-wedge high tibial osteotomy.
, J Orthop Res. , doi: 10.1002/jor.24845, 2020.09.
6. Yoshimoto K, Fukushi JI, Tsushima H, Kamura S, Miyahara HA, Mizu-Uchi H, Akasaki Y, Nakashima Y, Does Preparation of the Subtalar Joint for Primary Union Affect Clinical Outcome in Patients Undergoing Intramedullary Nail for Rheumatoid Arthritis of the Hindfoot and Ankle?, J Foot Ankle Surg, 59(5):984-987, 2020.09.
7. Kurakazu, Ichiro; Akasaki, Yukio; Hayashida, Mitsumasa; Tsushima, Hidetoshi; Goto, Norio; Sueishi, Takuya; Toya, Masakazu; Kuwahara, Masanari; Okazaki, Ken; Duffy, Tomas; Lotz, Martin K.; Nakashima, Yasuharu, FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor beta 1 signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 10.1074/jbc.RA119.009409, 294, 46, 17555-17569, 2019.11.
8. Rockel, Jason S.; Yu, Chunying; Whetstone, Heather; Craft, April M.; Reilly, Katherine; Ma, Henry; Tsushima, Hidetoshi; Puviindran, Vijitha; Al-Jazrawe, Mushriq; Keller, Gordon M.; Alman, Benjamin A., Hedgehog inhibits beta-catenin activity in synovial joint development and osteoarthritis, JOURNAL OF CLINICAL INVESTIGATION, 10.1172/JCI80205, 126, 5, 1649-1663, 2016.05.
9. Sueishi, Takuya; Akasaki, Yukio; Goto, Norio; Kurakazu, Ichiro; Toya, Masakazu; Kuwahara, Masanari; Uchida, Taisuke; Hayashida, Mitsumasa; Tsushima, Hidetoshi; Bekki, Hirofumi; Lotz, Martin K.; Nakashima, Yasuharu, GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-kappa B Signaling, ARTHRITIS & RHEUMATOLOGY, 10.1002/art.41152, 72, 4, 620-631, 2020.04.
10. Takayama, Yukihisa; Hatakenaka, Masamitsu; Tsushima, Hidetoshi; Okazaki, Ken; Yoshiura, Takashi; Yonezawa, Masato; Nishikawa, Kei; Iwamoto, Yukihide; Honda, Hiroshi, T1 rho is superior to T2 mapping for the evaluation of articular cartilage denaturalization with osteoarthritis: Radiological-pathological correlation after total knee arthroplasty, EUROPEAN JOURNAL OF RADIOLOGY, 10.1016/j.ejrad.2012.11.031, 82, 4, E192-E198, 2013.04.
11. Tang, Yuning J.; Huang, Jianguo; Tsushima, Hidetoshi; Ban, Ga I.; Zhang, Hongyuan; Oristian, Kristianne M.; Puviindran, Vijitha; Williams, Nerissa; Ding, Xiruo; Ou, Jianhong; Jung, Sin-Ho; Lee, Chang-Lung; Jiao, Yiqun; Chen, Benny J.; Kirsch, David G.; Alman, Benjamin A., Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis, CELL REPORTS, 10.1016/j.celrep.2019.08.029, 28, 11, 2837-+, 2019.09.
12. Tsushima, Hidetoshi; Tang, Yuning J.; Puviindran, Vijitha; Hsu, Shu-Hsuan Claire; Nadesan, Puviindran; Yu, Chunying; Zhang, Hongyuan; Mirando, Anthony J.; Hilton, Matthew J.; Alman, Benjamin A., Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis, DEVELOPMENT, 10.1242/dev.162396, 145, 13, 2018.07.
13. Tsushima, Hidetoshi; Okazaki, Ken; Ishihara, Kohei; Ushijima, Takahiro; Iwamoto, Yukihide, CCAAT/enhancer-binding protein beta promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis, ARTHRITIS RESEARCH & THERAPY, 10.1186/s13075-015-0532-6, 17, 2015.02.
14. Tsushima, Hidetoshi; Okazaki, Ken; Takayama, Yukihisa; Hatakenaka, Masamitsu; Honda, Hiroshi; Izawa, Toshiaki; Nakashima, Yasuharu; Yamada, Hisakata; Iwamoto, Yukihide, Evaluation of cartilage degradation in arthritis using T1 rho magnetic resonance imaging mapping, RHEUMATOLOGY INTERNATIONAL, 10.1007/s00296-011-2140-3, 32, 9, 2867-2875, 2012.09.
15. Ushijima, Takahiro; Okazaki, Ken; Tsushima, Hidetoshi; Ishihara, Kohei; Doi, Toshio; Iwamoto, Yukihide, CCAAT/Enhancer Binding Protein beta Regulates Expression of Indian Hedgehog during Chondrocytes Differentiation, PLOS ONE, 10.1371/journal.pone.0104547, 9, 8, 2014.08.
16. Ushijima, Takahiro; Okazaki, Ken; Tsushima, Hidetoshi; Iwamoto, Yukihide, CCAAT/Enhancer-binding Protein beta Regulates the Repression of Type II Collagen Expression during the Differentiation from Proliferative to Hypertrophic Chondrocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 10.1074/jbc.M113.492843, 289, 5, 2852-2863, 2014.01.
17. Zhang, Hongyuan; Wei, Qingxia; Tsushima, Hidetoshi; Puviindran, Vijitha; Tang, Yuning J.; Pathmanapan, Sinthu; Poon, Raymond; Ramu, Eyal; Al-Jazrawe, Mushriq; Wunder, Jay; Alman, Benjamin A., Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma, JCI INSIGHT, 10.1172/jci.insight.127232, 4, 11, 2019.06.
18. Tsushima, Hidetoshi; Okazaki, Ken; Hayashida, Mitsumasa; Ushijima, Takahiro; Iwamoto, Yukihide, CCAAT/enhancer binding protein beta regulates expression of matrix metalloproteinase-3 in arthritis, ANNALS OF THE RHEUMATIC DISEASES, 10.1136/annrheumdis-2011-200061, 71, 1, 99-107, 2012.01.
19. Goto N, Akasaki Y, Okazaki K, Kuwashima U, Iwasaki K, Kawamura H, Mizu-Uchi H, Hamai S, Tsushima H, Kawahara S, Nakashima Y., The influence of post-operative knee coronal alignment parameters on long-term patient-reported outcomes after closed-wedge high tibial osteotomy., J Orthop, 2020.01.
20. Akasaki Y, Mizu-Uchi H, Hamai S, Tsushima H, Kawahara S, Horikawa T, Nakashima Y., Patient-specific prediction of joint line convergence angle after high tibial osteotomy using a whole-leg radiograph standing on lateral-wedge insole., Knee Surg Sports Traumatol Arthrosc, 2019.12.