Kyushu University Academic Staff Educational and Research Activities Database
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AKIKO OKUMURA Last modified date:2022.06.08

 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Ph. D.
Country of degree conferring institution (Overseas)
Field of Specialization
pathological medicine
Total Priod of education and research career in the foreign country
Outline Activities
Project management and promotion of international collaboration
Research Interests
  • Research of the physiological role of ubiquitination-related factors
    keyword : ubiquitin, LUBAC (the Linear Ubiquitin Chain Assembly Complex), XIAP (X-Linked Inhibitor of Apoptosis Protein)
Academic Activities
1. Peterson LF, Boyapati A, Ahn EY, Biggs JR, Okumura Joo A, Lo MC, Yan M, Zhang DE, Acute Myeloid Leukemia with the 8q22;21q22 Translocation: Secondary Mutational Events and Alternative t(8;21) Transcripts., Blood, 2007.01, Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis..
1. Okumura Joo A, Peterson LF, Okumura F, Boyapati A, Zhang DE, t(8;21)(q22;q22) fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA binding sequences to differentially regulate gene expression., Blood , 112, 4, 1392-1401, 112(4): 1392-401, 2008.08.