九州大学-研究者情報 [佐々木江理子 (准教授) 理学研究院生物科学部門]

1.	Eriko Sasaki ,Joanna Gunis,Ilka Reichardt-Gomez,Viktoria Nizhynska,Magnus Nordborg, Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes, PLoS Genetics, 10.1371/journal.pgen.1010345, 2022.09, Genome-wide association studies (GWAS) have revealed that the striking natural variation for DNA CHH-methylation (mCHH; H is A, T, or C) of transposons has oligogenic architecture involving major alleles at a handful of known methylation regulators. Here we use a conditional GWAS approach to show that CHG-methylation (mCHG) has a similar genetic architecture - once mCHH is statistically controlled for. We identify five key trans-regulators that appear to modulate mCHG levels, and show that they interact with a previously identified modifier of mCHH in regulating natural transposon mobilization..
2.	Eriko Sasaki, Thomas Koecher, Daniele Filiault, Magnus Nordborg, Revisiting a GWAS peak in Arabidopsis thaliana reveals possible confounding by genetic heterogeneity, HEREDITY, 10.1038/s41437-021-00456-3, 2021.07.
3.	Sasaki E., Kawakatsu T., Ecker JR, Nordborg M, Common alleles of CMT2 and NRPE1 are major determinants of CHH methylation variation in Arabidopsis, PLoS Genetics, 2019.12.
4.	Sasaki E., Frommlet F, Nordborg M, GWAS with Heterogeneous Data: Estimating the Fraction of Phenotypic Variation Mediated by Gene Expression Data, G3-GENES GENOMES GENETICS, 10.1534/g3.118.200571, 8, 9, 3059-3068, 2018.09.
5.	†Kawakatsu T., †Huang SC., †Jupe F., †Sasaki E., Schmitz RJ., Urich MA., Castanon, R., Nery JR., Barragan C., He Y., Chen H., Dubin M., Lee C., Wang C., Bemm F., Becker C., O’Neil R., O’Malley RC., Quarless DX., The 1001 Genomes Consortium, Schork NJ, Weigel D., Nordborg M., Ecker JR., Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions Resource, Cell, 2016.07.
6.	Sasaki, Eriko; Zhang, Pei; Atwell, Susanna; Meng, Dazhe; Nordborg, Magnus, "Missing" G x E Variation Controls Flowering Time in Arabidopsis thaliana, PLOS GENETICS, 10.1371/journal.pgen.1005597, 11, 10, 2015.10.
7.	Goda, Hideki; Sasaki, Eriko; Akiyama, Kenji; Maruyama-Nakashita, Akiko; Nakabayashi, Kazumi; Li, Weiqiang; Ogawa, Mikihiro; Yamauchi, Yukika; Preston, Jeremy; Aoki, Ko; Kiba, Takatoshi; Takatsuto, Suguru; Fujioka, Shozo; Asami, Tadao; Nakano, Takeshi; Kato, Hisashi; Mizuno, Takeshi; Sakakibara, Hitoshi; Yamaguchi, Shinjiro; Nambara, Eiji; Kamiya, Yuji; Takahashi, Hideki; Hirai, Masami Yokota; Sakurai, Tetsuya; Shinozaki, Kazuo; Saito, Kazuki; Yoshida, Shigeo; Shimada, Yukihisa, The AtGenExpress hormone and chemical treatment data set: experimental design, data evaluation, model data analysis and data access, PLANT JOURNAL, 10.1111/j.1365-313X.2008.03510.x, 55, 3, 526-542, 2008.08.