Kyushu University Academic Staff Educational and Research Activities Database
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Yokomizo Hisashi Last modified date:2020.07.05



Graduate School


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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/hisashi-yokomizo
 Reseacher Profiling Tool Kyushu University Pure
http://www.intmed3.med.kyushu-u.ac.jp/english/
Phone
092-642-5284
Fax
092-642-5287
Academic Degree
Ph.D
Country of degree conferring institution (Overseas)
No
Field of Specialization
Diabetes, Endocrinology, Metabolism
ORCID(Open Researcher and Contributor ID)
0000-0001-7759-2014
Total Priod of education and research career in the foreign country
04years05months
Research
Research Interests
  • Clarification of the mechanism underlying diabetes induces skeletal muscle dysfunction
    keyword : Diabetes, Skeletal muscle
    2019.09.
Academic Activities
Papers
1. H. Yokomizo, Y. Maeda, K. Park, A. Clermont, S. Hernandez, W. Fickweiler, Q. Li, C. Wang, S. Paniagua, F. Simao, A. Ishikado, B. Sun, I. Wu, S. Katagiri, D. Pober, L. Tinsley, R. Avery, E. Feener, T. Kern, H. Keenan, L. Aiello, J. Sun, and GL. King. , Retinol Binding Protein 3 is increased in the retina of diabetic patients resistant to diabetic retinopathy., Science Translational Medicine, Sci Transl Med. 11 (499): Jul 3, 2019., 2019.07, The Joslin Medalist Study characterized people affected with type 1 diabetes for 50 years or longer. Over 35% of these individuals exhibit no to mild diabetic retinopathy (DR), independent of glycemic control, suggesting the presence of endogenous protective factors against DR in a subpopulation of patients. Proteomic analysis of retina and vitreous identified Retinol Binding Protein 3 (RBP3), a retinol transport protein secreted mainly by the photoreceptors, as elevated in medalist patients protected from advanced DR. Mass spectrometry and protein expression analysis identified an inverse association between vitreous RBP3 concentration and DR severity. Intravitreous injection and photoreceptor-specific overexpression of RBP3 in rodents inhibited the detrimental effects of vascular endothelial growth factor (VEGF). Mechanistically, our results showed that recombinant RBP3 exerted the therapeutic effects by binding to and inhibiting VEGF receptor tyrosine phosphorylation. In addition, by binding to GLUT1 and decreasing glucose uptake, RBP3 blocked the detrimental effects of hyperglycemia on inducing inflammatory cytokines in retinal endothelial and Müller cells. Elevated expression of photoreceptor-secreted RBP3 may have a role in protection against the progression of DR due to hyperglycemia by inhibiting glucose uptake via GLUT1 and decreasing the expression of inflammatory cytokines and VEGF..
2. H. Yokomizo, T. Inoguchi, N. Sonoda, Y. Sakaki, Y. Maeda, T. Inoue, E. Hirata, R. Takei, N. Ikeda, M. Fujii, K. Fukuda, H. Sasaki, and R. Takayanagi., Maternal high-fat diet induces insulin resistance and deterioration of pancreatic ß-cell function in adult offspring with sex differences in mice., American Journal of Physiology-Endocrinology and Metabolism, Am J Physiol Endocrinol Metab. 306: E1163-E1175, 2014., 2014.05.
Membership in Academic Society
  • Japan Society for the Study of Obesity
  • The Japan Endocrine Society
  • The Japan Diabetes Society
  • The Japanese Society of Internal Medicine
Educational
Educational Activities
Education for undergraduate students and graduate students
Other Educational Activities
  • 2019.09.