Kyushu University Academic Staff Educational and Research Activities Database
Search by Keyword How ro search
Keyword
Search Criteria
 
Detailed Search

Researcher information (To researchers) Need Help? How to update
Kyogo Kobayashi Last modified date：2023.12.06

Assistant Professor / Dynamic Biology
Department of Biology
Faculty of Sciences


Undergraduate School
Department of Biology
School of Sciences


Homepage
https://kyushu-u.elsevierpure.com/en/persons/kyogo-kobayashi
　Reseacher Profiling Tool　Kyushu University Pure
https://researchmap.jp/K_S_Kobayashi
researchmap .
Academic Degree
Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Neuroscience, Molecular Biology
ORCID(Open Researcher and Contributor ID)
0000-0002-2769-9646
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • Principles of learning and memory
    keyword : learning and memory, mice
    2020.04～2024.03.
Academic Activities
Reports
 Show All Reports >>
Papers
 Show All Papers >>
1. Kyogo S Kobayashi, Naoki Matsuo, Persistent representation of the environment in the hippocampus., Cell Reports, 10.1016/j.celrep.2022.111989, 42, 1, 111989-111989, 2023.01, In the hippocampus, environmental changes elicit rearrangement of active neuronal ensembles or remapping of place cells. However, it remains elusive how the brain ensures a consistent representation of a certain environment itself despite salient events occurring there. Here, we longitudinally tracked calcium dynamics of dorsal hippocampal CA1 neurons in mice subjected to contextual fear conditioning and extinction training. Overall population activities were significantly changed by fear conditioning and were responsive to footshocks and freezing. However, a small subset of neurons, termed environment cells, were consistently active in a specific environment irrespective of experiences. A decoder modeling study showed that these cells, but not place cells, were able to predict the environment to which the mouse was exposed. Environment cells might underlie the constancy of cognition for distinct environments across time and events. Additionally, our study highlights the functional heterogeneity of cells in the hippocampus..
2. Kyogo Kobayashi, Shunji Nakano, Mutsuki Amano, Daisuke Tsuboi, Tomoki Nishioka, Shingo Ikeda, Genta Yokoyama, Kozo Kaibuchi, Ikue Mori, Single-Cell Memory Regulates a Neural Circuit for Sensory Behavior, Cell Reports, 10.1016/j.celrep.2015.11.064, 14, 1, 11-21, 2016.01, Unveiling the molecular and cellular mechanisms underlying memory has been a challenge for the past few decades. Although synaptic plasticity is proven to be essential for memory formation, the significance of "single-cell memory'' still remains elusive. Here, we exploited a primary culture system for the analysis of C. elegans neurons and show that a single thermosensory neuron has an ability to form, retain, and reset a temperature memory. Genetic and proteomic analyses found that the expression of the single-cell memory exhibits inter-individual variability, which is controlled by the evolutionarily conserved CaMKI/IV and Raf pathway. The variable responses of a sensory neuron influenced the neural activity of downstream interneurons, suggesting that modulation of the sensory neurons ultimately determines the behavioral output in C. elegans. Our results provide proof of single-cell memory and suggest that the individual differences in neural responses at the single-cell level can confer individuality..
Works, Software and Database
1. MATLAB code used in Kobayashi and Matsuo, Cell Reports (2023)
[URL].
2. MATLAB code used in Kobayashi & Matsuo, Cell Reports (2023)
[URL].
Presentations
 Show All Presentations >>
Membership in Academic Society
  • Molecular and Cellular Cognition Society
  • Society for Neuroscience
  • THE JAPAN NEUROSCIENCE SOCIETY
Awards
  • The Best Bachelor Thesis Award
  • The Best Master Thesis Award
  • The Dean’s Outstanding Master Research Award
  • Annual Research Award, Integrative Graduate Education and Research Program


Unauthorized reprint of the contents of this database is prohibited.

Copyright © 2006, Kyushu University. All rights reserved.