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Takahiro Suzuki Last modified date：2024.06.03

Associate Professor / Department of Animal and Marine Bioresource Sciences
Department of Bioresource Sciences
Faculty of Agriculture


Graduate School
Department of Animal and Marine Bioresource Science
Graduate School of Bioresource and Bioenvironmental Sciences
Undergraduate School
Department of Bioresource and Bioenvironment
School of Agriculture


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Homepage
https://kyushu-u.elsevierpure.com/en/persons/takahiro-suzuki
　Reseacher Profiling Tool　Kyushu University Pure
Academic Degree
Ph. D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
skeletal muscle cell biology
ORCID(Open Researcher and Contributor ID)
0000-0002-7949-5477
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • Satellite cells are resident myogenic stem cells positioned beneath the basal lamina of mature myofibers. These cells differentiate to form nascent myofibers (myotubes) or fuse to injured myofibers for skeletal muscle regeneration and hypertrophy. Numerous studies focusing on cell dynamics such as quiescence, activation, proliferation, and differentiation, have shown that satellite cells exhibit heterogeneities based on the expression patterns of key transcription factors and cellular membrane proteins and determine the cell fate/linage. My research topics have directly focused on characterization of satellite cells based on myofiber types.
    keyword : Skeletal muscle, Myogenic stem cells (Satellite cells), Myofiber type, Multipotent-modulator, Functional heterogeneity
    2020.10.
Academic Activities
Reports
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Papers
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1. Takahiro Suzuki, Aika Mori, Takahiro Maeno, Rio Arimatsu, Emi Ichimura, Yuriko Nishi, Kouga Hisaeda, Yuki Yamaya, Ken Kobayashi, Mako Nakamura, Ryuichi Tatsumi, Koichi Ojima, Takanori Nishimura, Abundant Synthesis of Netrin-1 in Satellite Cell-Derived Myoblasts Isolated from EDL Rather Than Soleus Muscle Regulates Fast-Type Myotube Formation, International Journal of Molecular Sciences, 10.3390/ijms22094499, 22, 9, 4499-4499, 2021.04, Resident myogenic stem cells (satellite cells) are attracting attention for their novel roles in myofiber type regulation. In the myogenic differentiation phase, satellite cells from soleus muscle (slow fiber-abundant) synthesize and secrete higher levels of semaphorin 3A (Sema3A, a multifunctional modulator) than those derived from extensor digitorum longus (EDL; fast fiber-abundant), suggesting the role of Sema3A in forming slow-twitch myofibers. However, the regulatory mechanisms underlying fast-twitch myotube commitment remain unclear. Herein, we focused on netrin family members (netrin-1, -3, and -4) that compete with Sema3A in neurogenesis and osteogenesis. We examined whether netrins affect fast-twitch myotube generation by evaluating their expression in primary satellite cell cultures. Initially, netrins are upregulated during myogenic differentiation. Next, we compared the expression levels of netrins and their cell membrane receptors between soleus- and EDL-derived satellite cells; only netrin-1 showed higher expression in EDL-derived satellite cells than in soleus-derived satellite cells. We also performed netrin-1 knockdown experiments and additional experiments with recombinant netrin-1 in differentiated satellite cell-derived myoblasts. Netrin-1 knockdown in myoblasts substantially reduced fast-type myosin heavy chain (MyHC) expression; exogenous netrin-1 upregulated fast-type MyHC in satellite cells. Thus, netrin-1 synthesized in EDL-derived satellite cells may promote myofiber type commitment of fast muscles..
2. Kangmin Seo, Takahiro Suzuki, Ken Kobayashi, Takanori Nishimura, Adipocytes suppress differentiation of muscle cells in a co-culture system, Animal Science Journal, 10.1111/asj.13145, 90, 3, 423-434, 2019.03.
3. Tatsumi R, Suzuki T, Do MQ, Ohya Y, Anderson JE, Shibata A, Kawaguchi M, Ohya S, Ohtsubo H, Mizunoya W, Sawano S, Komiya Y, Ichitsubo R, Ojima K, Nishimatsu SI, Nohno T, Ohsawa Y, Sunada Y, Nakamura M, Furuse M, Ikeuchi Y, Nishimura T, Yagi T, Allen RE, Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells., Stem cells, 10.1002/stem.2639, 35, 7, 1815-1834, 2017.07.
4. Takahiro Suzuki, Mai-Khoi Q. Do, Yusuke Sato, Koichi Ojima, Minako Hara, Wataru Mizunoya, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi, Comparative analysis of semaphorin 3A in soleus and EDL muscle satellite cells in vitro toward understanding its role in modulating myogenin expression, The International Journal of Biochemistry & Cell Biology, 10.1016/j.biocel.2012.10.003, 45, 2, 476-482, 2013.02.
Presentations
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