Kyushu University Academic Staff Educational and Research Activities Database
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KAZUHISA HACHISUGA Last modified date:2023.11.22





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Homepage
https://kyushu-u.elsevierpure.com/en/persons/kazuhisa-hachisuga
 Reseacher Profiling Tool Kyushu University Pure
Country of degree conferring institution (Overseas)
No
Field of Specialization
gynecological oncology, gynecological pathology
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • Clinical significance of tumor immune microenvironment in endometrial endometrioid carcinoma, grade 1 with DNA mismatch repair protein loss
    keyword : endometrioid carcinoma, G1; MMR loss; tumor immune microenvironment; ICI therapies
    2022.10.
  • Endometrial endometrioid carcinoma and serous carcinoma are the two most common histologic types of uterine cancer. Although previously classified as Type 1 and Type 2, respectively, a comprehensive genomic analysis of uterine cancer published in 2013 classified uterine cancer into four molecular subtypes. Endometrial endometrioid carcinomas span all four subtypes, and serous carcinomas are essentially in the copy-number high group, which is characterized by abnormal p53 expression and is associated with the poorest prognosis. We have studied 269 cases of endometrial endometrioid carcinoma, G1, and found that abnormal p53 expression was not a significant poor prognostic factor in endometrial endometrioid carcinoma, G1. Therefore, it is important to consider how to treat serous carcinomas and endometrial endometrioid carcinomas with abnormal p53 expression when molecular subtypes are applied to clinical practice in the future. Therefore, we will compare serous carcinomas and endometrial endometrioid carcinomas with abnormal p53 expression using spatial transcriptome technology.


    keyword : endometrial endometiroid carcinoma, endometrial serous carcinoma, p53 expression
    2022.02~2024.03.
Academic Activities