Updated on 2025/06/13

Information

 

写真a

 
CHO IKSUNG
 
Organization
Institute for Materials Chemistry and Engineering Department of Soft Materials Chemistry Assistant Professor
Graduate School of Engineering （Concurrent）
School of Engineering （Concurrent）
Title
Assistant Professor
Contact information
メールアドレス
Homepage
External link

Research Areas

  • Life Science / Cell biology

  • Life Science / Biomaterials

Degree

  • Ph.D degree

Research History

  • University of Illinois at Chicago (Postdoctoral Researcher)   

Education

  • Kobe University   大学院工学研究科 化学工学専攻　  

    2016.10 - 2019.9

Research Interests・Research Keywords

  • Research theme： Tough, self-healable PMEA based hydrogel with enhanced blood-compatibility

    Keyword： PMEA, Self-healing, Mechanical properties, Hydrogel

    Research period： 2024.4 - 2025.3

  • Research theme： Enhancing Blood Compatibility of Chitosan Derivatives, Investigating the Role of Water State

    Keyword： Chitosan, Blood compatibility, Water state

    Research period： 2023.5 - 2024.12

  • Research theme： Developing hydrogels with advanced functionalities for tissue regeneration

    Keyword： Hydrogel, Stiffness

    Research period： 2023.1 - 2025.1

  • Research theme： Developing a new strategy for how novel biomaterials affect single stem cell behavior

    Keyword： Single-cell Encapsulation, Water molecule, Poly(2-Methoxyethyl Acrylate)

    Research period： 2023.1 - 2025.1

  • Research theme： Encapsulate single cell using engineered biomaterial to increase the retention time at target site and improve treatment of fibrosis.

    Keyword： Lung fibrosis, Single-cell encapsulation

    Research period： 2020.6 - 2022.12

  • Research theme： Introduce symmetric breaking micro-environment around single cell and determine how the polarized environment in single-cell level direct stem cell differentiation

    Keyword： Stem cell differentiation, Symmetric breaking, Single-cell encapsulation

    Research period： 2020.2 - 2022.8

  • Research theme： Polyrotaxane-based self-healing hydrogel with high mechanical stiffness excellent biocompatibility

    Keyword： Polyrotaxane-based hydrogel, Tough hydrogel, Self-healing hydrogel, Biocompatibility

    Research period： 2018.3 - 2020.2

  • Research theme： Tuned cell attachments by double-network hydrogels bearing robust and self-healing properties

    Keyword： Cell attachment, Double-network hydrogel, Self-healing properties

    Research period： 2018.1 - 2018.11

  • Research theme： A supramolecular hydrogel based on polyglycerol dendrimer-specific amino group recognition

    Keyword： Stimuli responsive polymer, Polyglycerol dendrimer

    Research period： 2017.10 - 2018.3

  • Research theme： Synthesis and characterization of injectable self-healing hydrogel

    Keyword： Injectable hydrogel, Self-healing polymer

    Research period： 2017.3 - 2017.10

  • Research theme： Synthesis and characterization of in situ crosslinkable glycol chitosan-based thermogels.

    Keyword： Dual crosslinkable polymer, Michael type addition reaction, Thermogelling polymer

    Research period： 2014.7 - 2016.8

  • Research theme： Preparation and evaluation of ocular drug delivery system using thermo-sensitive hexanoyl glycol chitosan.

    Keyword： Ocular delivery, Thermogelling polymer, Drug delivery

    Research period： 2014.7 - 2015.7

  • Research theme： Synthesis and evaluation of mucoadhesive thermo-gelling polymers.

    Keyword： Mucoadhesive polymer, Thermogelling polymer, Thiolated polymers

    Research period： 2014.6 - 2016.8

  • Research theme： Preparation of photo-crosslinkable glycol chitosan-based thermogels

    Keyword： Photo-crosslinkable hydrogel, Thermogelling polymer

    Research period： 2013.8 - 2015.3

  • Research theme： Synthesis and characterization of hexanoyl glycol chitosan as a thermogelling polymer.

    Keyword： Hydrogel, Thermogelling polymer, Glycol chitosan

    Research period： 2013.6 - 2013.8

Awards

  • Best student poster award

    2018.8   14th international chitin and chitosan conference  

  • Bajpai-Saha award

    2017.10   6th Asian biomaterial congress  

  • Best paper award

    2016.6   Korean society for biomaterials  

  • Best paper award

    2014.6   the 27th international symposium on chemical engineering  

Papers

  • Polyacrylamide Hydrogels with Reversibly Photocontrolled Stiffness for 2D Mechanobiology International coauthorship

    ACS Applied Materials & Interfaces   2025.6

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  • The Role of Intermediate Water in Enhancing Blood and Cellular Compatibility of Chitosan-Based Biomaterials

    Cho, IS; Shiomoto, S; Yukawa, N; Tanaka, Y; Huh, KM; Tanaka, M

    LANGMUIR   41 ( 12 )   8301 - 8311   2025.3   （ ISSN:0743-7463 eISSN:1520-5827 ）

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    Language：English   Publisher：Langmuir  

    Tissue engineering and regenerative medicine require biomaterials that balance blood compatibility with cell adhesion, proliferation, and differentiation. Chitosan and its derivatives, owing to their biocompatibility, biodegradability, and functional versatility, have been extensively explored for biomedical applications, including vascular grafts and tissue engineering scaffolds. This study investigates the effect of chemical modifications on the water state of chitosan derivatives─specifically, free water (FW), intermediate water (IW), and nonfreezing water (NFW)─and their implications for protein interactions, platelet adhesion, and mesenchymal stem cell (MSC) behavior. By incorporating hydrophilic and hydrophobic groups, the hydration of chitosan derivatives was precisely controlled, which significantly influenced blood compatibility and cell adhesion. Hexanoyl glycol chitosan (HGC) demonstrated reduced platelet adhesion, low fibrinogen denaturation, and favorable MSC adhesion, making it a promising candidate for applications requiring both enhanced blood compatibility and regenerative potential. These findings underscore the importance of hydration water modulation in designing advanced biomaterials for blood-contacting and regenerative medicine applications.

    DOI： 10.1021/acs.langmuir.5c00125

    Web of Science

    Scopus

    PubMed

  • Injectable Poloxamer Hydrogel Formulations for Intratympanic Delivery of Dexamethasone Reviewed International journal

    @Le, Thi Phuc; @Yu, Yang; @Cho, Ik Sung; @Suh, Eun Yeong; @Kwon, Hyuk Chan; @Shin, Sun-Ae; @Park, Yong-Ho; @Huh, Kang Moo

    JOURNAL OF KOREAN MEDICAL SCIENCE   38 ( 17 )   2023.4   （ ISSN:10118934 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Korean Medical Science  

    Background: In this study, we prepared and evaluated an injectable poloxamer (P407) hydrogel formulation for intratympanic (IT) delivery of dexamethasone (DEX). Methods: DEX-loaded P407 hydrogels were characterized in terms of thermogelation, drug loading capacities, particle size, and drug release. The in vivo toxicity and drug absorption of the DEX-loaded P407 formulation after IT injection were evaluated using an animal model by performing histopathological analysis and drug concentration measurements. Results: The P407 hydrogel effectively solubilized hydrophobic DEX and demonstrated a sustained release compared to the hydrophilic DEX formulation. The in vivo study showed that the hydrogel formulation delivered considerable drug concentrations to the inner ear and displayed a favorable safety profile without apparent cytotoxicity or inflammation. Conclusion: P407 hydrogel can be useful as an injectable inner ear delivery formulation for hydrophobic drugs due to their biocompatibility, drug-solubilizing capacity, thermogelation, and controlled release.

    DOI： 10.3346/jkms.2023.38.e135

    Scopus

  • Protein corona formation on epigallocatechin gallate-Au nanoparticles suppressed tumor accumulation

    Wakayama C., Inubushi S., Kunihisa T., Mizumoto S., Baba M., Tanino H., Cho I.S., Ooya T.

    Jcis Open   9   2023.4

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    Publisher：Jcis Open  

    Metal nanoparticles (NPs), such as gold NPs (AuNPs), are particularly sensitive to X-rays, and thus specific accumulation of AuNPs in a tumor would allow radiotherapy with low energy X-rays and reduced side effects. AuNPs can be generated using HAuCl<inf>4</inf> and the natural polyphenol epigallocatechin-3-gallate (EGCG) in the presence of citrate. Here, we generated EGCG-AuNPs in the presence of several additives and examined the accumulation of these NPs in mouse tumors following intravenous administration. EGCG-AuNPs 15 ​nm in diameter in the presence of sodium alginate accumulated more in tumors compared to 40-nm-diameter EGCG-AuNPs. Furthermore, the results of in vitro cellular uptake and serum protein absorption studies suggest that adsorption of 15–16 ​kDa serum proteins to EGCG-AuNPs suppresses accumulation in tumors. Thus, tendency to adsorb specific proteins on EGCG-AuNPs surface should be tailored for enhancing their accumulation in tumors.

    DOI： 10.1016/j.jciso.2023.100074

    Scopus

  • Deterministic Single Cell Encapsulation in Asymmetric Microenvironments to Direct Cell Polarity Reviewed International journal

    @Cho, Ik Sung; @Gupta, Prerak; @Mostafazadeh, Nima; @Wong, Sing Wan; @Saichellappa, Saiumamaheswari; @Lenzini, Stephen; @Peng, Zhangli; @Shin, Jae-Won

    ADVANCED SCIENCE   10 ( 3 )   2023.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Advanced Science  

    Various signals in tissue microenvironments are often unevenly distributed around cells. Cellular responses to asymmetric cell-matrix adhesion in a 3D space remain generally unclear and are to be studied at the single-cell resolution. Here, the authors developed a droplet-based microfluidic approach to manufacture a pure population of single cells in a microscale layer of compartmentalized 3D hydrogel matrices with a tunable spatial presentation of ligands at the subcellular level. Cells elongate with an asymmetric presentation of the integrin adhesion ligand Arg-Gly-Asp (RGD), while cells expand isotropically with a symmetric presentation of RGD. Membrane tension is higher on the side of single cells interacting with RGD than on the side without RGD. Finite element analysis shows that a non-uniform isotropic cell volume expansion model is sufficient to recapitulate the experimental results. At a longer timescale, asymmetric ligand presentation commits mesenchymal stem cells to the osteogenic lineage. Cdc42 is an essential mediator of cell polarization and lineage specification in response to asymmetric cell-matrix adhesion. This study highlights the utility of precisely controlling 3D ligand presentation around single cells to direct cell polarity for regenerative engineering and medicine.

    DOI： 10.1002/advs.202206014

    Scopus

  • Protein corona formation on epigallocatechin gallate-Au nanoparticles suppressed tumor accumulation Reviewed International journal

    @Chihiro Wakayama, @Sachiko @Inubushi, Tomonari Kunihisa, @Sachiko Mizumoto, @Motoi Baba, @Hirokazu Tanino, @Ik Sung Cho, @Tooru Ooya

    JCIS Open   2023.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Inhibition of aberrant tissue remodelling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cues Reviewed International journal

    @Wong, Sing Wan; @Tamatam, Chandramohan R.; @Cho, Ik Sung; @Toth, Peter T.; @Bargi, Raymond; @Belvitch, Patrick; @Lee, James C.; @Rehman, Jalees; @Reddy, Sekhar P.; @Shin, Jae-Won

    NATURE BIOMEDICAL ENGINEERING   6 ( 1 )   54 - +   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nature Biomedical Engineering  

    The precise understanding and control of microenvironmental cues could be used to optimize the efficacy of cell therapeutics. Here, we show that mesenchymal stromal cells (MSCs) singly coated with a soft conformal gel presenting defined chemomechanical cues promote matrix remodelling by secreting soluble interstitial collagenases in response to the presence of tumour necrosis factor alpha (TNF-α). In mice with fibrotic lung injury, treatment with the coated MSCs maintained normal collagen levels, fibre density and microelasticity in lung tissue, and the continuous presentation of recombinant TNF-α in the gel facilitated the reversal of aberrant tissue remodelling by the cells when inflammation subsided in the host. Gel coatings with predefined chemomechanical cues could be used to tailor cells with specific mechanisms of action for desired therapeutic outcomes.

    DOI： 10.1038/s41551-021-00740-x

    Scopus

  • Cell-Matrix Interactions Regulate Functional Extracellular Vesicle Secretion from Mesenchymal Stromal Cells Reviewed International journal

    @Lenzini, Stephen; @Debnath, Koushik; @Joshi, Jagdish C.; @Wong, Sing Wan; @Srivastava, Kriti; @Geng, Xue; @Cho, Ik Sung; @Song, Angela; @Bargi, Raymond; @Lee, James C.; @Mo, Gary C. H.; @Mehta, Dolly; @Shin, Jae-Won

    ACS NANO   15 ( 11 )   17439 - 17452   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acsnano.1c03231

  • Preparation and characterization of an in situ crosslinkable glycol chitosan thermogel for biomedical applications Reviewed International journal

    @Oh, Hye Min; @Kang, Eunae; @Li, Zhengzheng; @Cho, K. Sung; @Kim, Da Eun; @Mallick, Sudipta; @Kang, Sun-Woong; @Roh, Kyung-Ho; @Huh, Kang Moo

    JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY   80   820 - 828   2019.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jiec.2019.07.002

  • Cell‐Encapsulating Hydrogel Puzzle: Polyrotaxane‐Based Self‐Healing Hydrogels Reviewed International journal

    @I.S. Cho, @T. Ooya

    Chemistry–A European Journal   2019.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Tuned cell attachments by double-network hydrogels consisting of glycol chitosan, carboxylmethyl cellulose and agar bearing robust and self-healing properties Reviewed International journal

    @I.S. Cho, @T. Ooya

    International Journal of Biological Macromolecules   2019.8

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer Reviewed International journal

    @I.S. Cho, @H.M. Oh, @M.O. Cho, @B.S Jang, @J.K. Cho, @K.H. Park, @S. W. Kang, @K.M. huh

    Biomaterials research   2018.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • A Supramolecular Hydrogel Based on Polyglycerol Dendrimer‐Specific Amino Group Recognition Reviewed International journal

    @I.S. Cho, @T. Ooya

    Chemistry–An Asian Journal   2018.7

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease Reviewed International journal

    @Li, Zhengzheng; @Shim, Hyeeun; @Cho, Myeong Ok; @Cho, Ik Sung; @Lee, Jin Hyun; @Kang, Sun-Woong; @Kwon, Bosun; @Huh, Kang Moo

    CARBOHYDRATE POLYMERS   184   342 - 353   2018.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.carbpol.2018.01.006

  • An injectable and self-healing hydrogel for spatiotemporal protein release via fragmentation after passing through needles Reviewed International journal

    @I.S. Cho, @T. Ooya

    Journal of biomaterials science, polymer Edition   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Bioinspired tuning of glycol chitosan for 3D cell culture Reviewed International journal

    @Cho, Myeong Ok; @Li, Zhengzheng; @Shim, Hye-Eun; @Cho, Ik-Sung; @Nurunnabi, Md; @Park, Honghyun; @Lee, Kuen Yong; @Moon, Sung-Hwan; @Kim, Ki-Suk; @Kang, Sun-Woong; @Huh, Kang Moo

    NPG ASIA MATERIALS   8   2016.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/am.2016.130

  • Thermosensitive hexanoyl glycol chitosan-based ocular delivery system for glaucoma therapy Reviewed International journal

    @Cho, Ik Sung; @Park, Chun Gwon; @Huh, Beom Kang; @Cho, Myeong Ok; @Khatun, Zehedina; @Li, Zhengzheng; @Kang, Sun-Woong; @Bin Choy, Young; @Huh, Kang Moo

    ACTA BIOMATERIALIA   39   124 - 132   2016.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.actbio.2016.05.011

  • Synthesis and characterization of a new photo-crosslinkable glycol chitosan thermogel for biomedical applications Reviewed International journal

    @Cho, Ik Sung; @Cho, Myeong Ok; @Li, Zhengzheng; @Nurunnabi, Md; @Park, Sung Young; @Kang, Sun-Woong; @Huh, Kang Moo

    CARBOHYDRATE POLYMERS   144   59 - 67   2016.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.carbpol.2016.02.029

  • Synthesis of N-Acetylated Glycol Chitosans and Their Thermo-sensitive Sol-Gel Transition Properties Reviewed

    @You, Ho Seon; @Cho, Myeong Ok; @Cho, Ik Sung; @Li, Zhengzheng; @Kim, Nam-Hong; @Jang, Mi-Kyeong; @Kang, Sun-Woong; @Huh, Kang Moo

    POLYMER-KOREA   40 ( 2 )   328 - 335   2016.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.7317/pk.2016.40.2.328

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Presentations

  • キトサン誘導体の血液適合性の向上　DSCによる水の状態の役割に関する検討(Enhancing Blood Compatibility of Chitosan Derivatives: Investigating the Role of Water State by DSC)

    Cho Iksung, Shiomoto Shohei, Tanaka Yukiko, Huh Kang-Moo, Tanaka Masaru

    日本バイオマテリアル学会大会予稿集  2023.10  日本バイオマテリアル学会

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    Event date： 2023.11

    Language：English  

  • Deterministic symmetry breaking of single cells in three-dimensional matrices

    @Ik Sung Cho, @Jae-Won Shin

    Gordon Research Seminar  2022.7 

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    Event date： 2022.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Matrix-mediated symmetry breaking of single cells in a three-dimensional space

    @Ik Sung Cho, @Jae-Won Shin

    American Society For Biomaterial  2022.4 

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    Event date： 2022.4

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Matrix-mediated symmetry breaking of single cells in a three-dimensional space

    @Ik Sung Cho, @Jae-Won Shin

    American Physical Society  2022.3 

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    Event date： 2022.3

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Engineering single cell polarity in three-dimensional matrices

    @Ik Sung Cho, @Jae-Won Shin

    American Society For Biomaterial  2021.4 

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    Event date： 2021.4

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Cell encapsulation and proliferation in polyrotaxane-based self-healing hydrogel

    @Ik Sung Cho, @Tooru Ooya

    36th Cyclodextrin Symposium  2019.9 

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    Event date： 2019.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Extremely Soft Biocompatible Polysaccharide-based Self-healing Slide-ring Hydrogel International conference

    @Ik Sung Cho, @Tooru Ooya

    International Congress on Pure & Applied Chemistry  2019.8 

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    Event date： 2019.8

    Language：English   Presentation type：Oral presentation (general)  

    Country：Myanmar  

  • Polyrotaxane-based self-healing hydrogel for the tissue engineering

    @Ik Sung Cho, @Tooru Ooya

    The Society of Polymer Science  2019.5 

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    Event date： 2019.5

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Injectable and Self-healing Carbohydrate-based Hydrogel for Protein Delivery International conference

    @Ik Sung Cho, @Tooru Ooya

    6th Asian biomaterial congress  2017.10 

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    Event date： 2017.10

    Language：English   Presentation type：Oral presentation (general)  

    Country：India  

  • Synthesis and characterization of photo-crosslinkable thermogelling hexanoyl glycol chitosan International conference

    @Ik Sung Cho, @Kang Moo Huh

    The 27th international symposium on chemical engineering  2014.12 

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    Event date： 2014.12

    Language：English   Presentation type：Oral presentation (general)  

    Country：Malaysia  

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MISC

Industrial property rights

Patent   Number of applications: 0   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 高分子学会

    2023.4 - Present

  • American society of biomaterials

  • American Physical society

  • American Heart association

Outline of Social Contribution and International Cooperation activities

  • My academic journey, spanning Korea, Japan, and the United States, has afforded me a unique perspective in fostering social contributions and international collaborations. In this essay, I'll detail how my educational and research experiences across these diverse cultures have deepened my understanding of social dynamics, broadened my global outlook, and equipped me with the skills necessary for significant contributions to social and international projects. Throughout my journey, I've built a vast network of colleagues, mentors, and collaborators in these countries, creating a wealth of opportunities for partnerships aimed at addressing societal challenges. By leveraging these connections, I am able to unite experts from various fields, institutions, and nations to tackle complex issues. The varied perspectives and expertise in my network encourage cross-cultural exchanges, share best practices, and foster the development of innovative solutions, amplifying our collective impact.