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Ikegami Yasuhiro Last modified date：2023.11.22

Assistant Professor / Department of Chemical Engineering
Faculty of Engineering


Graduate School
Graduate School of Engineering
Department of Materials Process Engineering
Graduate School of Engineering
Undergraduate School
School of Engineering
Department of Materials Science and Engineering
School of Engineering


E-Mail　*Since the e-mail address is not displayed in Internet Explorer, please use another web browser:Google Chrome, safari.
Homepage
https://kyushu-u.elsevierpure.com/en/persons/yasuhiro-ikegami
　Reseacher Profiling Tool　Kyushu University Pure
http://www.chem-eng.kyushu-u.ac.jp/lab8/
Laboratory of Biomaterial & Medical Engineering (Ijima Lab.) HP .
Phone
092-802-2768
Fax
092-802-2768
Academic Degree
Doctor of Engineering
Country of degree conferring institution (Overseas)
No
Field of Specialization
Biochemical Engineering, Medical Engineering, Biomaterial, Neural Tissue Engineering
ORCID(Open Researcher and Contributor ID)
0000-0003-2594-3307
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • Development of medical devices using functional biomaterials
    keyword : Electrospun nanofiber, Extracellular matrix-modeled material
    2017.04.
Academic Activities
Books
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1. Yasuhiro Ikegami, Hiroyuki Ijima, Immobilization Strategies: Biomedical, Bioengineering and Environmental Applications -Strategies and advancement in growth factor immobilizable ECM for tissue engineering-, Springer, https://doi.org/10.1007/978-981-15-7998-1_3, 2023.06.
2. Yasuhiro Ikegami, Hiroyuki Ijima, Decellularization of Tissue and Whole Organs in Tissue Engineering -Decellularization of Nervous Tissues and Efforts for their Clinical Application-, Springer, https://doi.org/10.1007/978-3-030-82735-9_19, 2021.09, [URL].
Papers
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1. Yasuhiro Ikegami, Hideyuki Mizumachi, Kozue Yoshida, Hiroyuki Ijima, Heparin-conjugated collagen as a potent growth factor-localizing and stabilizing scaffold for regenerative medicine, Regenerative Therapy, 10.1016/j.reth.2020.10.002, 15, 236-242, 2020.12.
2. Yasuhiro Ikegami, Hiroyuki Ijima, Development of heparin-conjugated nanofibers and a novel biological signal by immobilized growth factors for peripheral nerve regeneration, Journal of Bioscience and Bioengineering, 10.1016/j.jbiosc.2019.09.004, 129, 3, 354-362, 2020.03.
3. Akshat Joshi, Zhe Xu, Yasuhiro Ikegami, Kozue Yoshida, Yusuke Sakai, Akshay Joshi, Tejinder Kaur, Yosuke Nakao, Yo-ichi Yamashita, Hideo Baba, Shinichi Aishima, Neetu Singh, Hiroyuki Ijima, Exploiting synergistic effect of externally loaded bFGF and endogenous growth factors for accelerated wound healing using heparin functionalized PCL/gelatin co-spun nanofibrous patches, Chemical Engineering Journal, 10.1016/j.cej.2020.126518, 404, 126518-126518, 2021.01, Growth factors (GFs) are signaling molecules that are principle mediators in tissue regeneration. Biomaterial scaffolds employed as wound dressings are often hampered by their limitations to deliver GFs exogenously due to their instability and low half-life. The key to overcome this challenge lies in the better organization and use of endogenous pro-regenerative GFs released at regenerative site, with an aim to minimize the sole dependency on exogenous factors. Considering such challenges, this research utilizes the exogenous and endogenous GFs sequestering capability of heparin functionalized PCL/gelatin co-spun nanofabrics to mediate synergistically driven tissue regeneration by utilizing combined therapeutic effect of exogenous and endogenous GFs, and thereby minimizing the sole dependency on exogenous GFs for tissue regeneration. Basic fibroblast growth factor (bFGF) was chosen as GF for exogenous loading whereas vascular endothelial growth factor (VEGF) was chosen as a representative example to demonstrate the endogenous pro-regenerative GF sequestration capability of fabricated nanofabrics. From our results, the fabricated nanofabrics showed loading efficiency of 80% for exogenous bFGF and can sequester 15-fold more amount of endogenous VEGF compared to non-heparin functionalized nanofibrous dressings. When applied as wound dressings, heparin functionalized nanofibers showed better therapeutic capability compared to control groups that were treated using patches without heparin functionalization, indicating endogenously driven tissue regeneration. This was indicated by significant higher number of newly formed skin appendages, lesser scarring and lower inflammatory levels in newly formed granulation. Additionally, further improvements in therapeutic effect was observed when exogenous bFGF was employed indicating effectiveness of synergistically mediated tissue regeneration..
4. Yasuhiro Ikegami, Muhammad Shafiq, Shinichi Aishima, Hiroyuki Ijima, Correction to: Heparin/Growth Factors-Immobilized Aligned Electrospun Nanofibers Promote Nerve Regeneration in Polycaprolactone/Gelatin-Based Nerve Guidance Conduits, Advanced Fiber Materials, 10.1007/s42765-023-00261-z, 5, 2, 696-696, 2023.02.
Presentations
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