YAMAMOTO SHOTA
Organization
Medical Institute of Bioregulation Medical Research Center for High Depth Omics Assistant Professor
Title
Assistant Professor
Contact information
External link
Degree
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Ph.D.
Research Interests・Research Keywords
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Research theme：Understanding the brain based on lipid metabolism
Keyword：lipid metabolism, central nervous system
Research period： 2023.4
Awards
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2023年度海外学会等参加費用援助
2022.12 公益信託 医用薬物研究奨励富岳基金
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第34回（2022年度）加藤記念国際交流助成
2022.10 公益財団法人 加藤バイオサイエンス振興財団
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Postdoctoral Award
2019.6
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優秀発表賞
2018.3 日本薬学会第138年会
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優秀発表賞
2016.11 第69回日本薬理学会西南部会
Papers
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Lipid in microglial biology - from material to mediator. International journal
Shota Yamamoto, Takahiro Masuda
Inflammation and regeneration 43 ( 1 ) 38 - 38 2023.7
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Profiling of fatty acid metabolism in the dorsal root ganglion after peripheral nerve injury. International journal
Shota Yamamoto, Tomomi Hashidate-Yoshida, Takao Shimizu, Hideo Shindou
Frontiers in pain research (Lausanne, Switzerland) 3 948689 - 948689 2022.7
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Neuroprotective effects of ibudilast against tacrolimus induced neurotoxicity. International journal
Wei Zhang, Ryosuke Matsukane, Nobuaki Egashira, Yuichi Tsuchiya, Rao Fu, Shota Yamamoto, Takeshi Hirota, Ichiro Ieiri
Toxicology and applied pharmacology 449 116112 - 116112 2022.6
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Lysophosphatidic acid receptor1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses. International journal
Yoko Hoshino, Toshiaki Okuno, Daisuke Saigusa, Kuniyuki Kano, Shota Yamamoto, Hideo Shindou, Junken Aoki, Kanji Uchida, Takehiko Yokomizo, Nobuko Ito
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36 ( 4 ) e22236 2022.4
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Lipid signaling in chemotherapy-induced peripheral neuropathy
Shota Yamamoto, Nobuaki Egashira
Current Opinion in Toxicology 28 1 - 6 2021.12
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Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats.
Nobuaki Egashira, Yu Goto, Ryota Takahashi, Hikari Iba, Shota Yamamoto, Takuya Watanabe, Kaori Kubota, Takehiro Kawashiri, Chise Taniguchi, Shutaro Katsurabayashi, Katsunori Iwasaki
Journal of pharmacological sciences 147 ( 1 ) 114 - 117 2021.9
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Drug Repositioning for the Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: A Mechanism- and Screening-Based Strategy
Shota Yamamoto, Nobuaki Egashira
Frontiers in Pharmacology 11 2021.1
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Pathological Mechanisms of Bortezomib-Induced Peripheral Neuropathy
Shota Yamamoto, Nobuaki Egashira
International Journal of Molecular Sciences 22 ( 2 ) 888 - 888 2021.1
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Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development. International journal
William J Valentine, Tomomi Hashidate-Yoshida, Shota Yamamoto, Hideo Shindou
Advances in experimental medicine and biology 1274 5 - 27 2020.9
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Lysophosphatidylethanolamine acyltransferase 2 (LPEAT2) incorporates DHA into phospholipids and has possible functions for fatty acid-induced cell death. International journal
Miki Eto, Hideo Shindou, Shota Yamamoto, Miwa Tamura-Nakano, Takao Shimizu
Biochemical and biophysical research communications 526 ( 1 ) 246 - 252 2020.5
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New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats.
Yamamoto S, Yamashita T, Ito M, Caaveiro JMM, Egashira N, Tozaki-Saitoh H, Tsuda M
International journal of cancer 145 ( 8 ) 2107 - 2113 2019.10
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Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats.
Yamamoto S, Egashira N, Tsuda M, Masuda S
Journal of pharmacological sciences 138 ( 3 ) 214 - 217 2018.11
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Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug
Shota Yamamoto, Soichiro Ushio, Nobuaki Egashira, Takehiro Kawashiri, Shohei Mitsuyasu, Hitomi Higuchi, Nana Ozawa, Ken Masuguchi, Yuko Ono, Satohiro Masuda
SCIENTIFIC REPORTS 7 ( 1 ) 9661 2017.8
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Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury
Tomohiro Yamashita, Shota Yamamoto, Jiaming Zhang, Miho Kometani, Daisuke Tomiyama, Keita Kohno, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsuda
PLOS ONE 11 ( 10 ) e0165189 2016.10
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Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor.
129 ( 3 ) 196 - 199 2015.11
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Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats
Shota Yamamoto, Takehiro Kawashiri, Hitomi Higuchi, Kuniaki Tsutsumi, Soichiro Ushio, Takanori Kaname, Masafumi Shirahama, Nobuaki Egashira
JOURNAL OF PHARMACOLOGICAL SCIENCES 129 ( 1 ) 43 - 50 2015.9
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Inhibition of Ca2+/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats
Masafumi Shirahama, Soichiro Ushio, Nobuaki Egashira, Shota Yamamoto, Hikaru Sada, Ken Masuguchi, Takehiro Kawashiri, Ryozo Oishi
MOLECULAR PAIN 8 26 2012.4
MISC
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血小板活性化因子（PAF）シグナル遮断による神経障害性がん疼痛の克服—PAF-Pain Loop遮断を標的とした新規カテゴリー鎮痛薬開発へ
山本 将大, 進藤 英雄
医学のあゆみ 2019.11
Professional Memberships
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北米神経科学学会
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THE JAPANESE BIOCHEMICAL SOCIETY
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THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS
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日本緩和医療薬学会
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JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
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THE PHARMACEUTICAL SOCIETY OF JAPAN
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THE JAPANESE PHARMACOLOGICAL SOCIETY
Research Projects
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アラキドン酸含有リン脂質が担う難治性疼痛の新しい病態メカニズム
Grant number：23K06820 2023 - 2025
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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アラキドン酸含有リン脂質が担う神経障害性疼痛の新しい病態メカニズム
2022
Grant type：Donation
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「生体膜リン脂質－膜タンパク質連関」から紐解く神経障害性疼痛発症メカニズムの解明
Grant number：21J00759 2021 - 2023
日本学術振興会 科学研究費助成事業 特別研究員奨励費
Authorship：Principal investigator Grant type：Scientific research funding
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新しい疼痛制御分子「リン脂質生合成酵素」を標的にしたドラッグリポジショニング研究
Grant number：21K15309 2021 - 2022
日本学術振興会 科学研究費助成事業 若手研究
Authorship：Principal investigator Grant type：Scientific research funding
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神経障害性疼痛におけるω６系脂肪酸含有リン脂質の役割解明と疼痛治療への応用
2021
Grant type：Donation
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ミクログリアにおける膜リン脂質ダイナミクスの調節機構解明と難治性疼痛治療への応用
2021
Grant type：Donation
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生体膜リン脂質生合成酵素群に注目した難治性疼痛に対する新規治療標的の同定
2020
Grant type：Donation
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生体膜リン脂質操作による神経障害性疼痛の発症維持メカニズムの解明
Grant number：19K16938 2019 - 2020
日本学術振興会 科学研究費助成事業 若手研究
Authorship：Principal investigator Grant type：Scientific research funding
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ハイスループットスクリーニングによる抗がん薬誘発末梢神経障害の新規保護薬の探索研究
2017
アカデミックチャレンジ2017年度
Authorship：Principal investigator Grant type：On-campus funds, funds, etc.