Kyushu University Academic Staff Educational and Research Activities Database
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Takashi Niwa Last modified date:2024.02.22



Graduate School
Undergraduate School


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Homepage
https://kyushu-u.elsevierpure.com/en/persons/takashi-niwa
 Reseacher Profiling Tool Kyushu University Pure
https://niwagroup.jp/home-en/
The website of Laboratory for Molecular Transformation Chemistry, Kyushu University. .
Academic Degree
Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Organic Synthetic Chemistry, Organic Reaction Chemistry, Radiolabeling Chemistry
ORCID(Open Researcher and Contributor ID)
0000-0002-6209-5362
Total Priod of education and research career in the foreign country
01years00months
Outline Activities
Our group aims for developing novel reaction chemistry to create new transformation methodologies and molecular structures that can contribute to promoting interdisciplinary fields, such as life and medicinal sciences. For this purpose, we focus on synthetic organic and organometallic chemistry, functional molecule synthesis, and mechanistic studies. The research themes can be summarized below:
1. Exploring reaction chemistry that enables novel transformations
2. Developing late-stage modification methods with various external stimuli
3. Developing practical synthetic methods for functional molecules
Research
Research Interests
  • Development of coupling reactions driven by electrophilic activation of metal centers
    keyword : Transition metal-catalysis, cross-coupling reactions, electrophilic activation
    2018.04.
  • Creation of molecular probes using biological equivalents
    keyword : Bioisosteres, fluoroalkenes, molecular probe
    2015.04.
  • Innovation in positron emission tomography (PET) probe development through organic reaction development
    keyword : Reaction discovery, PET imaging, molecular probe
    2013.04.
  • Development of asymmetric oxidation reactions utilizing iron(cazbox) complexes exhibiting iron porphyrin-like reactivity
    keyword : Asymmetric reaction, oxidation, iron porphyrins
    2009.04~2013.03.
  • Development of oxidative bond formation reactions using highly oxidized transition metals
    keyword : Oxidation, transition metals
    2009.04.
  • Developing transition metal-catalyzed organic reactions involving stable chemical bond cleavage
    keyword : catalysis, inert covalent bond, C-C bond activation
    2004.04.
Academic Activities
Papers
1. Zhouen Zhang, Takashi Niwa, Kenji Watanabe, Takamitsu Hosoya, 11C‐Cyanation of Aryl Fluorides via Nickel and Lithium Chloride‐Mediated C–F Bond Activation, Angewandte Chemie International Edition, 10.1002/anie.202302956, 62, e202302956, 2023.03.
2. Takashi Niwa, Tsuyoshi Tahara, Charles E. Chase, Francis G. Fang, Takayoshi Nakaoka, Satsuki Irie, Emi Hayashinaka, Yasuhiro Wada, Hidefumi Mukai, Kenkichi Masutomi, Yasuyoshi Watanabe, Yilong Cui, Takamitsu Hosoya, Synthesis of 11C-Radiolabeled Eribulin as a Companion Diagnostics PET Tracer for Brain Glioblastoma, Bulletin of the Chemical Society of Japan, 10.1246/bcsj.20220335, 96, 3, 283-290, 2023.03.
3. Takashi Niwa, Yuta Uetake, Motoyuki Isoda, Tadashi Takimoto, Miki Nakaoka, Daisuke Hashizume, Hidehiro Sakurai, Takamitsu Hosoya, Lewis acid-mediated Suzuki–Miyaura Cross-Coupling Reaction, Nature Catalysis, https://www.nature.com/articles/s41929-021-00719-6, 4, 12, 1080-1088, 2021.08, The palladium-catalysed Suzuki–Miyaura cross-coupling (SMC) reaction of organohalides and organoborons is a reliable method for carbon–carbon bond formation. This reaction involves a base-mediated transmetalation process, but the presence of a base also promotes competitive protodeborylation, which reduces the efficiency. Herein, we established an SMC reaction via Lewis acid-mediated transmetalation of an organopalladium(II) intermediate with organoborons. Experimental and theoretical investigations indicate that the controlled release of the transmetalation-active intermediate enabled base-independent transmetalation under heating conditions and enhanced the applicable scope of this process. This system enabled us to avoid the addition of a base, and thus, rendered substrates with base-sensitive moieties available. Results from this research further expand the overall utility of cross-coupling chemistry..
Membership in Academic Society
  • Japanese Society of Nuclear Medicine
  • THE PHARMACEUTICAL SOCIETY OF JAPAN
  • Japanese Society of Molecular Imaging
  • JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
Awards
  • Best Poster Award
  • RIKEN Research Incentive Award
  • RIKEN CLST Research Incentive Award
  • Young Scientist's Research Award in Natural Product Chemistry
  • The Chemical Society of Japan Award For Young Chemists for 2017
  • RIKEN BAIHO Award
  • The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology,
  • Thieme Chemistry Journals Award
  • Best Presentation Award in the 16th Annual Meeting of Japanese Society for Molecular Imaging
  • The BCSJ Award