Satoshi Fujimoto
Assistant Professor
Science for Biological Information
Department of Basic Medicine
Faculty of Medical Sciences
Last modified date：2024.04.10
Graduate School
Undergraduate School
Other Organization
Research Interests
- Mechanisms of activity-dependent neural circuit formation
keyword : Neural circuit formation
2017.04.
Academic Activities
Papers
| 1. |
Satoshi Fujimoto, Marcus N. Leiwe, Shuhei Aihara, Richi Sakaguchi, Yuko Muroyama, Reiko Kobayakawa, Ko Kobayakawa, Tetsuichiro Saito, Takeshi Imai , Activity-dependent local protection and lateral inhibition control synaptic competition in developing mitral cells in mice, Developmental Cell, 10.1016/j.devcel.2023.05.004, 2023.06, In developing brains, activity-dependent remodeling facilitates the formation of precise neuronal connectivity. Synaptic competition is known to facilitate synapse elimination; however, it has remained unknown how different synapses compete with one another within a post-synaptic cell. Here, we investigate how a mitral cell in the mouse olfactory bulb prunes all but one primary dendrite during the developmental remodeling process. We find that spontaneous activity generated within the olfactory bulb is essential. We show that strong glutamatergic inputs to one dendrite trigger branch-specific changes in RhoA activity to facilitate the pruning of the remaining dendrites: NMDAR-dependent local signals suppress RhoA to protect it from pruning; however, the subsequent neuronal depolarization induces neuron-wide activation of RhoA to prune non-protected dendrites. NMDAR-RhoA signals are also essential for the synaptic competition in the mouse barrel cortex. Our results demonstrate a general principle whereby activity-dependent lateral inhibition across synapses establishes a discrete receptive field of a neuron.. |
Presentations
| 1. |
Satoshi Fujimoto, Marcus Leiwe, Shuhei Aihara, Richi Sakaguchi, Yuko Muroyama, Reiko Kobayakawa, Ko Kobayakawa, Tetsuichiro Saito, Takeshi Imai, Activity-dependent local protection and lateral inhibition control developmental dendrite pruning in mitral cells, Axon 2023 - Development, Plasticity & Regeneration of Neural Circuits, 2023.09. |
| 2. |
Satoshi Fujimoto, Marcus Leiwe, Shuhei Aihara, Richi Sakaguchi, Yuko Muroyama, Reiko Kobayakawa, Ko Kobayakawa, Tetsuichiro Saito, Takeshi Imai, Activity-dependent lateral inhibition signals for synaptic competition, EMBO Workshop - Mechanisms of neuronal remodelling, 2023.03, [URL]. |
| 3. |
Satoshi Fujimoto, Marcus N. Leiwe, Shuhei Aihara, Richi Sakaguchi, Yuko Muroyama, Reiko Kobayakawa, Ko Kobayakawa, Tetsuichiro Saito, Takeshi Imai, Activity-dependent competition within a neuron ensures the discrete wiring of mitral cell dendrites, 第44回日本神経科学大会 CJK第1回国際会議, 2021.07. |
| 4. |
Satoshi Fujimoto, Takeshi Imai, Activity-dependent competition within a neuron ensures the discrete wiring of mitral cell dendrites, 遺伝研研究会, 2020.12. |
Membership in Academic Society
- Society for Neuroscience
- The Japan Neuroscience Society
- The Japanese Biochemical Society
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