| Taizo Hanai | Last modified date：2013.4.18 |
Graduate School
Undergraduate School
E-Mail
Homepage
[URL]
Homepage of Associate Professor Hanai.
Phone
092-642-6751
Fax
092-642-6744
Academic Degree
Doctor of Engineering
Field of Specialization
Biochemical Engineering
Outline Activities
Research and Education
Improvement of Bio-fuel production by metabolic engineering
Creation of artificial genetic circuit by synthetic biology
Bioinformatics for bioengineering and medical application
Social activities
Editorial Board, Journal of Bioscience and Bioengineering (2009-2013)
Editorial Advisory Board, Bioprocess and Biosystems Engineering (2006-2013)
Member of Electrical Information Committee in The Society for Biotechnology, Japan (2006-2011)
Editor for Biomedia in The Society for Biotechnology, Japan (1998-2000)
Improvement of Bio-fuel production by metabolic engineering
Creation of artificial genetic circuit by synthetic biology
Bioinformatics for bioengineering and medical application
Social activities
Editorial Board, Journal of Bioscience and Bioengineering (2009-2013)
Editorial Advisory Board, Bioprocess and Biosystems Engineering (2006-2013)
Member of Electrical Information Committee in The Society for Biotechnology, Japan (2006-2011)
Editor for Biomedia in The Society for Biotechnology, Japan (1998-2000)
Research
Research Interests
- Construction of artifical gene network by synthetic biology
keyword : Synthetic Biology, Artificial Genetic Circut, System Biology, Molecular Biology, Simulation, System Design, System Analysis
2007.06. - Improvement of biofuel production by metabolic engineering
keyword : Metabolic Engineering, Bioalcohol, Metabolic Flux Analysis, Simulation, Bioinformatics, Transcriptome, Proteome, Metabolome
2006.08.
- Recently, rapid increasing of oil price has made us pay attention to biofuel production. We have already succeeded to produce some types of alcohols by unnatural producer E.coli. It is well known that E.coli has a fast growth rate and one of most user-friendly organisms for gene manipulation. These merits can help improvement of the biofuel production. We use the simulation technology to estimate the flux of metabolite. Based on the simulation result, we can decide the enzyme to be modified or over expressed or deleted. Produced alcohols are poison for E.coli, so it is also important to create the stronger E.coli against alcohols. For this purpose, we are using the analysis result of the data from transcriptome, proteome and metabolome by bioinformatics techniques.
- In order to produce bioalcohol from carbon dioxide and solar energy, engineered cynobacteria is created.
- Recently, small number of research groups started to study named "artificial genetic circuit" or "synthetic biology" in systems biology research area. This study aims to realize oscillation or complicated phenomenon of gene expression by analysis of interactions or control of genes or proteins and by combination of them artificially. In order to realize such kind complicated phenomenon, we must estimate dynamisms of large number of bio-molecules. For this purpose, not only gene manipulation, but also simulation and system analysis are needed. Now, we are tying to create biological systems to realize oscillator of gene expression.
Books
| 1. | Taizo Hanai, Hiroyuki Honda, Takeshi Kobayashi,Soft Computing in Chemistry,Springer-Verlag,p.135-159,2003.03. |
Reports
| 1. | Taizo Hanai, Hiroyuki Hamada, Masahiro Okamoto,Application of bioinformatics for DNA microarray data to Bioscience,2006.05. |
Papers
| 1. | Shota Atsumi, Taizo Hanai, James C. Liao,Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels,Nature,451, 7174, 86-89,2008.01. |
| 2. | Shota Atsumi, Anthony F. Cann, Michael R. Connor, Claire R. Shen, Kevin M. Smith, Mark P. Brynildsen, Katherine J.Y. Chou, Taizo Hanai, James C. Liao,Metabolic engineering of Escherichia coli for 1-butanol production,Metabolic Engineering,10(6), 305-311,2008.11. |
| 3. | Yoshihiko Tashima, Hiroyuki Hamada, Masahiro Okamoto, Taizo Hanai,Prediction of Key Factor for Control of G1/S Phase in Mammalian Cell Cycle by using System Analysis,Journal of Bioscience and Bioengineering,2008.09. |
| 4. | Taizo Hanai, Shota Atsumi, James C. Liao,Engineered synthetic pathway for isopropanol production in Escherichia coli,Applied and Environmental Microbiology,73, 24, 7814-7818 ,2007.12. |
| 5. | Koujiro Nishida, Shinji Mine, Tohru Utsunomiya, Hiroshi, Inoue, Masahiro Okamoto, Harushi Udagawa, Taizo Hanai, Masaki Mori,Global analysis of altered gene expressions during the process esophageal squamous cell carcinogenesis in the rat: a study combined with a laser microdissection and cDNA microarray,Cancer Research,Vol.65,No.2,65, 2, 401-409,2005.02. |
| 6. | Shuta Tomida, Taizo Hanai, Hiroyuki Honda and Takeshi Kobayashi,Gene expression analysis using fuzzy ART model,Bioinformatics,18, 8, 1073-1083,2002.08. |
| 7. | Hideki Noguchi, Taizo Hanai, Wataru Takahashi, Tomohiko Ichii, Mitsuru Tanikawa, Susumu Masuoka, Hiroyuki Honda and Takeshi Kobayashi : Model construction for quality of beer and brewing process using FNN, Kagaku Kougaku Ronbunshu, 25(5), 695-701(1999) (in Japanese). |
Educational
Educational Activities
Class : Unit Operation (Department of Agriculture, 2nd Grade)
Core seminar (All Department)
Brief lecture of Bioscience and Biotechnology (All Department)
Systems Biology(Graduate School of Bioresources and Bioenvironmental Science)
Systems Biotechnology (Graduate School of Bioresources and Bioenvironmental Science)
Advanced Biological Function and Regulation (Graduate School of Bioresources and Bioenvironmental Science)
Advanced Applied Biological Regulation Technology (Graduate School of Bioresources and Bioenvironmental Science)
Systems for Biological Information (Graduate School for Systems Life Sciences)
Basic Systems Biology (Graduate School for Systems Life Sciences)
Core seminar (All Department)
Brief lecture of Bioscience and Biotechnology (All Department)
Systems Biology(Graduate School of Bioresources and Bioenvironmental Science)
Systems Biotechnology (Graduate School of Bioresources and Bioenvironmental Science)
Advanced Biological Function and Regulation (Graduate School of Bioresources and Bioenvironmental Science)
Advanced Applied Biological Regulation Technology (Graduate School of Bioresources and Bioenvironmental Science)
Systems for Biological Information (Graduate School for Systems Life Sciences)
Basic Systems Biology (Graduate School for Systems Life Sciences)
Social
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