九州大学 研究者情報
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基本情報 研究活動 教育活動 社会活動
秋田 健行(あきた たけゆき) データ更新日:2019.03.15

助教 /  薬学研究院 創薬科学部門 生体分子情報学講座


主な研究テーマ
高感度キラルHPLC分析を可能とする新規蛍光誘導体化法の開発
キーワード:キラル HPLC 蛍光 誘導体化試薬
2016.06.
高選択的キラルHPLC分析を可能とする新規充填剤の開発
キーワード:HPLC、充填剤、キラル、
2016.06.
超常磁性酸化物ナノパーティクルを用いた、反応の磁場制御
キーワード:反応の磁場制御
2009.04.
水素結合を利用した分子間スピン相互作用の制御
キーワード:分子磁性、水素結合、スピン相互作用、超分子、ラジカル、カルベン
1997.04.
光応答型超高スピン有機化合物の構築
キーワード:分子磁性、高スピン、デンドリマー、ポリマー、ジアゾ、カルベン、ラジカル
2000.04~2016.08.
従事しているプロジェクト研究
超常磁性酸化鉄ナノパーティクルを用いた反応の磁場制御
2009.04~2012.03.
研究業績
主要原著論文
1. Chiharu Ishii, Takeyuki Akita, Masashi Mita, Tomomi Ide, Kenji Hamase, Development of an online two-dimensional high-performance liquid chromatographic system in combination with tandem mass spectrometric detection for enantiomeric analysis of free amino acids in human physiological fluid, Journal of Chromatography A, 10.1016/j.chroma.2018.07.076, 1570, 91-98, 2018.10, [URL], An automated two-dimensional HPLC-MS/MS system was designed and developed for the highly selective determination of trace levels of D-amino acids. As the targets, frequently observed ones in mammalian physiological fluids, Ala, Asp, Glu, Leu, Pro and Ser, were selected because these D-amino acids are the potential biomarkers for the early and sensitive diagnoses of various diseases. The target analytes were derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F), then isolated by a reversed-phase column in the first dimension. The NBD-amino acid fractions were automatically collected into the multi-loop device, and introduced into the enantioselective column in the second dimension to separate the D- and L-forms followed by detection by an MS/MS. The obtained resolution values of the enantiomers were 1.87–5.17 and the calibration lines, precision and accuracy were practically sufficient. By using the present 2D HPLC-MS/MS system, trace levels of D-amino acids in complex biological matrices were determined without disturbance by the intrinsic interfering compounds, and successfully applied to the analysis of the human clinical samples (plasma and urine)..
2. Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Yurika MIYOSHI, Masashi MITA, Kenji HAMASE, Development of a highly-sensitive two-dimensional HPLC system with narrowbore reversed-phase and microbore enantioselective columns and application to the chiral amino acid analysis of the mammalian brain, Chromatography, 10.15583/jpchrom.2018.007, 39, 83-90, 2018.04.
3. Nutchaya SEREEKITTIKUL, Reiko KOGA, Takeyuki AKITA, Aogu FURUSHO, Roland REISCHL, Masashi MITA, Akira FUJII, Kazunori HASHIGUCHI, Masanobu NAGANO, Wolfgang LINDNER, Kenji HAMASE, Multi-dimensional HPLC analysis of serine containing chiral dipeptides in Japanese traditional amber rice vinegar, Chromatography, 10.15583/jpchrom.2018.002, 39, 59-66, 2018.03.
4. Chin-Ling Hsieh, Aogu Furusho, Takeyuki Akita, Masashi Mita, Tomomi Ide., Jen-Ai Lee, Kenji Hamase, Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human plasma and urine using a narrowbore online two-dimensional HPLC system, Journal of Separation Science, 10.1002/jssc.201701283, 41, 1298-1306, 2018.01.
5. Junzo Hirano, Kenji Hamase, Takeyuki Akita, Kiyoshi Zaitsu, Structural and photophysical properties of novel dual fluorescent compounds, 1-aryl-substituted 6-methoxy-4-quinolones, Luminescence, 10.1002/bio.1044, 23, 5, 350-355, 2008.10, [URL], Dual fluorescent compounds are useful platforms for the development of ratiometric probes and sensors. We have developed a new series of dual fluorescent compounds, 1-aryl-substituted 6-methoxy-4-quinolones, and investigated their structural and photophysical properties. The X-ray crystallographic analysis and ab initio quantum chemical calculations revealed that the developed compounds exhibited 60-75° twisted structures. The dual fluorescence of the compounds were observed in polar solvents, and the ratiometric fluorescence responses to alterations in the acidity and temperature were obtained..
6. Takeyuki Akita, Noboru Koga, Magnetic properties of dendritic polycarbenes substituted by bulky peripheral groups, Polyhedron, 10.1016/j.poly.2005.03.067, 24, 16-17, 2321-2325, 2005.11, [URL], As photo-reactive precursors of high-spin organic compounds sterically separated from surroundings by bulky peripheral groups, diphenyldiazomethane derivatives substituted by tetrakis{3,5-bis(benzyloxy)benzyloxy} groups 1, by tetrakis[3,5-bis{3′,5′-bis(benzyloxy)benzyloxy}bezyloxy] groups 2, and nonakisdiazo compound associated with ferromagnetic spin couplers substituted by dodecakis{3,5-bis(benzyloxy)benzyloxy} groups 3, were prepared and their magnetic properties after irradiation in their own condensed films were investigated. Field dependences of magnetization and temperature dependences of χT value after irradiation of 1 and 2 clearly exhibited that spin centers i.e., diphenylcarbene parts of 1 and 2 were magnetically isolated from surrounding molecules each other by steric hindrance of the peripheral bulk substituents even in the neat films. In the case of 3, some part of molecules interacted antiferromagnetically with neighboring molecules but a fatal strong antiferromagnetic interaction was also avoided..
7. Junzo Hirano, Kenji Hamase, Takeyuki Akita, Kiyoshi Zaitsu, Crystal structure of 6-methoxy-4-quinolone, C10H9NO2·2H2O, Analytical Sciences: X-ray Structure Analysis Online, 10.2116/analscix.21.x45, 21, 3, x45, 2005.01, [URL], The title compound, 6-methoxy-4-quinolone (3), was synthesized by the oxidation of 5-methoxyindole-3-acetic acid (2), and its crystal structure was determined by X-ray diffraction analysis. The compound crystallized in the monoclinic system, space group P21/n, with cell parameters of a = 4.547(2)Å, b = 16.328(8)Å, c = 13.731(4)Å, β = 92.38(2)°, and Z = 4. The final residual factor was 0.064. 2005.
8. Junzo Hirano, Kenji Hamase, Takeyuki Akita, Kiyoshi Zaitsu, Crystal structure of N-[(6-methoxy-4-oxo-1,4-dihydroquinolin-3-yl) methyl]-2,2-dimethylpropanamide, Analytical Sciences: X-ray Structure Analysis Online, 10.2116/analscix.20.x115, 20, 3, x115-x116, 2004.01, [URL], The crystal structure of N-[(6-methoxy-4-oxo-1,4-dihydroquinolin-3-yl)methyl]-2,2-dimethylpropanamide (2) was determined by X-ray diffraction analysis. The compound crystallized in the triclinic system, space group P1, with cell parameters of a = 7.829(3)Å, b = 8.995(4)Å, c = 10.646(5)Å, α = 85.86(2)o, β = 86.99(1)o, γ = 88.00(2)o, and Z = 2. The structure was refined by full-matrix least-squares to final values of R1 = 0.049 and wR2 = 0.103. The intermolecular hydrogen bonds of the type N-H···O were observed in the structure. 2004.
9. Jingping Zhang, Madoka Suehiro, Akira Sakane, Satoru Karasawa, Takeyuki Akita, Noboru Koga, Theoretical study on the exchange interaction between metal ion and organic radical through pyridine, bipyridine and terpyridine ligands, Molecular Crystals and Liquid Crystals, 10.1080/10587250210747, 376, 431-436, 2002.12, [URL], Ab initio total energy calculations with the DFT framework based on the geometries obtained by X-ray data were carried out for five complexes composed by copper(II) ion and organic radicals (eg. aminoxyl and carbene) through pyridine, bipyridine and terpyridine rings. It was found that the copper(II) complex having radical substituted at 4-position of aromatic ligand favors ferromagnetic coupling between organic radical and paramagnetic copper(II) ion..
10. Yves Pontillon, Takeyuki Akita, Andre Grand, Keiji Kobayashi, Eddy Lelievre-Berna, Jacques Pécaut, Eric Ressouche, Jacques Schweizer, Experimental and theoretical spin density in a ferromagnetic molecular complex presenting interheteromolecular hydrogen bonds, Journal of the American Chemical Society, 10.1021/ja991042u, 121, 43, 10126-10133, 1999.11, [URL], The association of phenylboronic acid (no unpaired electron, compound 1) with the free radical phenyl nitronyl nitroxide (PNN, S = 1/2 , compound 2) constitutes an interheteromolecular hydrogen bonding system displaying ferromagnetic intermolecular interactions. We have investigated its spin density distribution to visualize the pathway of these magnetic interactions. This complex crystallizes at room temperature in the monoclinic space group P21/n. The unit cell includes one pair (1 + 2). The molecule (1) bridges two radicals (2) by hydrogen bonds OH···ON: the two different hydrogen bond lengths are quite similar (1.95 and 1.92 Å). Infinite chains of this run along the b-axis. In this structure the methyl groups of the PNN are randomly distributed in two different configurations. Below T = 220 K the compound undergoes a crystallographic phase transition due to the ordering of these methyl groups. We have determined the low-temperature structure using both X- ray and neutron diffraction. The new space group is P1̄. The global structure is preserved and infinite chains still run along the b-axis, but the unit cell now comprises two different pairs (1 + 2) instead of one, with four different hydrogen bond OH···ON distances: 1.96 and 1.84 Å for the first pair, 1.96 and 1.91 Å for the second pair. The spin density of this complex was measured at T = 1.8 K (H = 4.6 T) by polarized neutron diffraction. The data were treated using both maximum entropy approach and wave function modeling. As in the isolated PNN, the main part of the spin density is located on the O-N-C-N-O fragment of each radical in the unit cell. However, compared to the isolated case, a significant difference exists: a large unbalance is observed between the two oxygen atoms of each radical. Moreover, a positive contribution is found on the two hydrogen atoms involved on the OH···ON hydrogen bonds of each phenylboronic acid molecule. The stronger contribution corresponds to the longer hydrogen bonds. On the radical the stronger reduction is observed on the oxygen atoms involved in the shorter hydrogen bonds. The experimental results are compared to those obtained by density functional theory (DFT) calculations: on the whole, the experimental effects have been reproduced. However, if there is a good qualitative agreement, from the quantitative point of view, the DFT results are still very far from the experimental ones..
11. Satoru Karasawa, Yoko Sano, Takeyuki Akita, Noboru Koga, Tetsuji Itoh, Hiizu Iwamura, Pierre Rabu, Marc Drillon, Photochemical formation of ferrimagnetic chains from a pair of polymeric complexes made of octahedral bis(hexafluoroacetylacetonato)manganese(II) with diazodi(4-pyridyl)methane in the cis and trans configurations as repeating units, Journal of the American Chemical Society, 10.1021/ja981293n, 120, 39, 10080-10087, 1998.10, [URL], Two kinds of 1:1 manganese complexes a and b of bis(hexafluoroacetylacetonato)manganese(II) coordinated with diazodi(4- pyridyl)methane (1) were prepared. Complexes a and b crystallize in the orthorhombic space group Pbca and in monoclinic C2/c, respectively. Two pyridyl nitrogen atoms from two different molecules of 1 are coordinated in the cis and trans configurations to the manganese ion to form helical and zigzag infinite chains of octahedral manganese complexes in complexes a and b, respectively. The magnetic susceptibilities (χmol) of both crystals before and after irradiation were measured on a SQUID susceptometer and revealed χ(mol)T vs T plots characteristic of ferrimagnetic chains after irradiation for 97 h; interaction between the manganese(II) ion and the photogenerated carbene is antiferromagnetic in both complexes. The antiferromagnetic exchange coupling parameters (J) in the photolyzate of complex a and b were estimated by a theoretical treatment through a procedure of extrapolation by using small rings to be J/k(B) = -34.8 ± 0.8 and -24.4 ± 0.5 K, respectively. Maximum χ(mol)T values of 210 at 5 K for cis- and 246 emu·K·mol-1 at 1.9 K for trans complexes correspond to correlation lengths of 186 and 218 manganese-carbene S = 3/2 units, respectively..
12. Takeyuki Akita, Keiji Kobayashi, Intermolecular spin-coupler
Ferromagnetic spin interactions through hydrogen bond in the complexes of arylboronic acids with aryl nitronyl nitroxides, Molecular Crystals and Liquid Crystals, 10.1080/10587259708044574, 306, 257-264, 1997.01, [URL], Two crystalline complexes, the complex of p-fluorophenylboronic acid with phenyl nitronyl nitroxide (2) and the complex of p-nitrophenylboronic acid with p-dimethylaminophenyl nitronyl nitroxide (3), were prepared. Both of those complexes as well as the complex of phenylboronic acid with phenyl nitronyl nitroxide (1) exhibit ferromagnetic spin interactions (1: J/kB=+0.65 K, 2: J/kB=+0.58 K, 3: J/kB=+1.35 K). The results are discussed based on the X-ray crystal structure..
13. Takeyuki Akita, Keiji Kobayashi, Magnetic properties of nitronyl nitroxide radicals substituted in phenylboronic acid
The BOH⋯O hydrogen bond as a constituent unit of a one-dimensional suprastructure exhibiting a ferromagnetic spin interaction, Advanced Materials, 10.1002/adma.19970090414, 9, 4, 346-349, 1997.01, [URL].
14. Junpei Fujita, Yoshihisa Matsuoka, Kenji Matsuo, Masakazu Tanaka, Takeyuki Akita, Noboru Koga, Hizu Iwamura, Molecular structure and magnetic properties of N,N-bis {4-methoxy-3,5-bis(N-tert-butyl-N-oxyamino)phenyl} aminoxyl. An approach to a stable and high-spin pentaradical, Chemical Communications, 10.1039/a704160h, 24, 2393-2394, 1997.01, [URL], A stable pentaradical, N,N-bis(4-methoxy-3,5-bis(N-tert-butyl-N-oxyamino)phenyl)]aminoxyl, is prepared and its ground state determined to be a sextet (S = 5/2) by SQUID magnetization measurements of the pentaradical diluted in poly(vinyl chloride) matrix..
15. Takeyuki Akita, Yasuhiro Mazaki, Keiji Kobayashi, Ferromagnetic spin interaction through the interheteromolecular hydrogen bond
A 1:1 crystalline complex of phenylboronic acid and phenyl nttronyl nitroxide, Molecular Crystals and Liquid Crystals, 278-279, 39-45, 1996.12, A crystalline molecular complex derived from phenyl nitronyl nitroxide (1) and phenyl boronic acid (2) exhibits a ferromagnetic spin interaction (J= +0.65 K) below 30 K: An X-ray analysis revealed the crystal structure constituted of one-dimensional array of two component molecules linked alternately by the NO-HO-B hydrogen bonds. The NO-HO-B-OH - ON linkage was suggested to act as a path for ferromagnetic spin coupling. An unusual formation of nitrosonium salt (3) was found in the reaction of 1 and BF3. Its molecular and crystal structures were determined..
16. Takeyuki Akita, Keiji Kobayashi, Intramolecular spin-interactions between two nitronyl nitroxide or imino nitroxide radical units linked to thieno[2,3-b]thiophene and thieno[2,3-b]thieno[3',2'-d]thiophene chromophores, Tetrahedron, 10.1016/0040-4020(96)00324-9, 52, 20, 6893-6902, 1996.05, [URL], Diradical species 1N, 1I, 2N, and 2I, in which two nitronyl nitroxide (N) or imino nitroxide (I) radical centers are attached to thieno[23-b]thiophene (1) and thieno[23-b]thieno[3' 2' -d]thiophene (2) chromophores, respectively, were prepared and their intramolecular exchange interactions were investigated in frozen solutions by means of ESR spectroscopy and magnetic susceptibility measurements at cryogenic temperature. Temperature dependence of the ESR signal intensities due to the triplet state revealed that bis(nitronyl nitroxide) radicals, 1N and 2N, are ground-state singlet species with quite small singlet-triplet gaps. In bis(imino nitroxide) radical 1I the spin interaction was antiferromagnetic and the singlet-triplet gap was estimated to be 2J/kB= -18 K. On the other hand, bis(imino nitroxide) 21 was revealed to be a singlet-triplet degenerate species. These results are discussed in terms of the intramolecular NO - S contact along with corroboration by the semi-empirical MO calculations..
17. Takeyuki Akita, Yasuhiro Mazaki, Keiji Kobayashi, Ferromagnetic spin interaction in a crystalline molecular complex formed by inter-heteromolecular hydrogen bonding
A 1:1 complex of phenyl nitronyl nitroxide radical and phenylboronic acid, Journal of the Chemical Society, Chemical Communications, 10.1039/C39950001861, 18, 1861-1862, 1995.09, [URL], A crystalline molecular complex derived from phenyl nitronyl nitroxide and phenylboronic acid exhibits a ferromagnetic spin interaction (J = +0.65 K) below 30 K: X-ray analysis reveals the crystal structure to be constituted of a one-dimensional array of two component molecules linked alternately by the NO ⋯ HOB hydrogen bond..
18. Takeyuki Akita, Yasuhiro Mazaki, Keiji Kobayashi, Noboru Koga, Hiizu Iwamura, Crystal structures and magnetic properties of nitronyl nitroxide and imino nitroxide radicals attached to thieno[3,2-b]- and thieno[2,3-b]thiophene rings, Journal of Organic Chemistry, 60, 7, 2092-2098, 1995.04, Nitronyl nitroxide (ONC=NO) and imino nitroxide (NCNO) free radicals joined to isomeric thieno-[3,2-b]thiophene and thieno[2,3-b]thiophene, respectively, were prepared and their crystal structures and magnetic properties were investigated. In all crystals of four free radical species, the ON-C-NO moieties are in the same plane as the thienothiophene ring. The coplanarity is associated with the extremely short intramolecular contact between the oxygen atom in the NO group and the sulfur atom in the thienothiophene ring. The free radicals attached to thieno[3,2-b]thiophene are arranged in a chain structure with short intermolecular NO-S contacts, while the free radicals linked to thieno[2,3-b]thiophenes make dimers with a face-to-face pairing by the use of the NO-S contacts. Among four radical species, thieno[3,2-b]thiophene-substituted nitronyl nitroxide exhibits a weak ferromagnetic interaction (J = +0.11 K/kB, H = -2JSiSj) below 40 K as revealed by a SQUID susceptometer, while others are antiferromagnetic..
主要学会発表等
1. Kenta SAKAI, Kenji UEKI, Reiko KOGA, Yurika MIYOSHI, Takeyuki AKITA, Masashi MITA, Ryuichi KONNO, Tomomi IDE, Kenji HAMASE, Development of a Two-Dimensional Chiral HPLC System for Leucine Structural Isomers and Determination of Their Urinary Levels, HPLC 2017 Jeju, 2017.11.
2. Kenji HAMASE, Takeyuki AKITA, Masashi MITA, Hiroshi NARAOKA, Wolfgang Lindner, Multi-Dimensional Chiral HPLC Analysis of Amino Acids in Clinical Samples and Extraterrestrial Materials, HPLC 2017 Jeju, 2017.11.
3. Aogu FURUSHO, Reiko KOGA, Yurika MIYOSHI, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Design and Development of a Three-Dimensional HPLC System for Chiral Amino Acid Analysis in Human Clinical Samples, HPLC 2017 Jeju, 2017.11.
4. Kenji UEKI, Takeyuki AKITA, Yasuhiko KADOTA, Yasuhiro NISHIO, Yurika MIYOSHI, Masashi MITA, Akio Ojida, Kenji HAMASE, Development of high resolution Pirkle-type chiral stationary phases and application to D-amino acid analysis in biological matrices, HPLC 2017 PRAGUE, 2017.06.
5. 植木 健治, 秋田 健行, 門田 靖彦, 西尾 康弘, 三田 真史, 濵瀬健司, 新規Pirkle型キラル固定相の設計・作製とNBD-アミノ酸/ジペプチドの分離特性解析, 第24回クロマトグラフィーシンポジウム, 2017.06.
6. 吉田 あすみ, 秋田 健行, 古賀 鈴依子, 植木 健治, 佐藤 裕, 三田 真史, 濵瀬健司, トリプトファンNBD誘導体の高感度蛍光キラルHPLC分析法開発, 日本薬学会 第137年会, 2017.03.
7. Takeyuki AKITA, ACCELERATION OF REACTION BETWEEN TWO MOIETIES ON THE SURFACES OF SPIONS BY STATIC MAGNETIC FIELDS, XVII International Symposium on Luminescence Spectrometry, 2016.11.
8. Kenji UEKI, Takeyuki AKITA, Yu SATO, Reiko KOGA, Yasuhiko KADOTA, Yasuhiro NISHIO, Yurika MIYOSHI, Masashi MITA, Akio OJIDA, Kenji HAMASE, DESIGN OF A NOVEL HIGH RESOLUTION PIRKLE-TYPE CHIRAL STATIONARY PHASE AND SEPARATION OF NBD-AMINO ACID ENANTIOMERS, XVII International Symposium on Luminescence Spectrometry, 2016.11.
9. 秋田 健行, 古賀 登, SPION表面保護ポリマーに導入した官能基間の反応と磁場効果, 第24回基礎有機化学討論会, 2013.09, 反応を磁場で制御する試みは以前より行われているが、一般的な反応に広範に応用が可能な方法論については未だに確立されていない。そこで今回、超常磁性酸化鉄ナノパーティクル(SPION)の表面保護ポリマーにそれぞれ反応が可能な官能基を導入した二種類のSPIONを用い、磁場によりSPION間の距離をコントロールすることにより反応を制御することを試みた。.
10. 秋田健行・古賀登, Pd触媒を導入したSPIONを用いたSPIONからの機能分子の放出反応の検討
, 日本化学会第92春季年会, 2012.03, パラジウム触媒を表面に導入した超常磁性鉄酸化物ナノパーティクル(SPION)1を合成し、これを用いて、ブテニルエーテルを介してフルオレセイン誘導体を導入したSPION 2からの蛍光分子の放出反応について検討を行った。.
11. 秋田 健行・古賀 登, 超常磁性酸化鉄ナノパーティクル表面への蛍光性物質の導入と放出反応の検討, 第22回基礎有機化学討論会, 2011.09, 超常磁性酸化鉄ナノパーティクルは近年、ドラッグデリバリーシステム(DDS)やMRI造影剤等の生体内イメージング剤への応用が期待され、盛んに研究が行われている。その際にSPION表面への機能性分子の導入と、生体内環境や外部からの刺激による機能性分子の選択的な放出の機構が重要となる。本研究では機能分子のモデルとしてフルオレセイン誘導体及びニトロフェノールを用い、アミノブテニルリンカーを通した機能性分子の表面保護部への導入と、Pd(0)によるアリールエーテル部位の切断反応を用いた選択的放出反応について検討を行った。.
特許出願・取得
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学会活動
所属学会名
クロマトグラフィー科学会
日本化学会
学会大会・会議・シンポジウム等における役割
2018.08.28~2018.08.29, 第31回バイオメディカル分析科学シンポジウム(BMAS2018), 実行委員(会計).
2003.04, The 10th International Workshop on Bio-Medical ESR Spectroscopy and Imaging, 座長(Chairmanship).
2003.03, 日本化学会第83春期年会, 座長(Chairmanship).
2006.10, 第18回基礎有機化学連合討論会, 実行委員会委員.
学術論文等の審査
年度 外国語雑誌査読論文数 日本語雑誌査読論文数 国際会議録査読論文数 国内会議録査読論文数 合計
2006年度      
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2009年度~2011年度, 挑戦的萌芽研究, 代表, 超常磁性鉄酸化物ナノパーティクルを用いた反応の磁場制御.
2003年度~2006年度, 特定領域研究(A)特定領域研究(B), 分担.
2002年度~2004年度, 基盤研究(A), 分担.
2000年度~2001年度, 奨励研究(A), 代表, 水素結合の多点認識による有機高スピン超分子の構築.
1998年度~1999年度, 奨励研究(A), 代表, 光水素移動反応による有機磁性の可逆的スイッチ.
1997年度~1999年度, 基盤研究(B), 分担.

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