| 1. |
An approoach to scoring backing errors for Japanese palatalized misarticulation with repaired. |
| 2. |
Naoki Kaneko, Junsei Sameshima, Shintaro Kawano, Toru Chikui, Takeshi Mitsuyasu, Hu Chen, Taiki Sakamoto, Seiji Nakamura, Comparison of computed tomography findings between odontogenic keratocyst and ameloblastoma in the mandible: Criteria for differential diagnosis, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, https://doi.org/10.1016/j.ajoms.2022.07.016, Volume 35, Issue 1, 15-22, 2023.01, Objectives: Appropriate differential diagnosis between odontogenic keratocysts (OKCs) and ameloblastomas before treatment is crucial, but the radiographic findings, including computed tomography (CT), are often similar. This study, therefore, aimed to compare the CT findings of OKCs and ameloblastomas in the mandible.
Methods: Forty-one OKC and 28 ameloblastoma patients were radiologically evaluated by using initial CT images focusing on features such as long/short diameters, CT values, the appearance of the cortex, locularity, scalloped margins, sclerotic rims, and high-density structures. Subtypes of ameloblastoma were also considered. Statistical analyses, including multivariate logistic regression analysis, were performed to determine the features that were helpful for differential diagnosis.
Results: Short diameters and locularity were found to be significant features in the differential diagnosis. Between
unicystic and conventional ameloblastomas, the frequency of sclerotic rims and buccal disappearance was significantly different. Based on these results, criteria were established for differential diagnosis between OKCs and ameloblastomas, and the diagnostic accuracy was 92.8 %.
Conclusion: This finding indicates that several CT findings are strikingly different between OKCs and ameloblastomas, and that these criteria for differential diagnosis are clinically useful.. |
| 3. |
Kyoko Tsuji, Naoto Haruyama, Shunsuke Nomura, Naohisa Murata, Keigo Yoshizaki, Takeshi Mitsuyasu, Hiroyuki Nakano, Seiji Nakamura, Yoshihide Mori and Ichiro Takahashi, Characteristics of craniofacial morphology and factors affecting them in patients with isolated cleft palate, PeerJ, 10.7717/peerj.11297, 2021.04, Background: Myriad maxillo-mandibular occlusal relationships are observed in patients with isolated cleft palate (ICP), unlike in patients with other cleft types, such as cleft lip and palate.
Objectives: This study aimed to categorise the characteristics of craniofacial morphology in patients with ICP, and investigate the clinical factors affecting these categorised morphological characteristics.
Methods: Thirty-six girls with ICP (age (mean ± SD): 5.36 ± 0.36 years) underwent cephalometric measurement. Their craniofacial morphology was categorised using cluster analysis. Profilograms were created and superimposed onto the standard Japanese profilograms to visualise the morphological characteristics of each group (cluster). The mean values and variations in the linear and angular measurements of each group were compared with the Japanese standards and statistically analysed using Dunnett’s test after the analysis of variance. Fisher’s exact test was used to analyse the differences between the cleft types (cleft in the hard and/or soft palate) and skills of the operating surgeons in the groups.
Results: Cluster analysis of craniofacial morphologies in patients with ICP resulted in the formation of three categories: the first cluster exhibited a relatively harmonious anteroposterior relationship between the maxilla and the mandible (22.2%); the second cluster exhibited crossbite owing to a significantly smaller maxilla (33.3%); and the third cluster exhibited a smaller mandible with posterior rotation showing skeletal class II malocclusion (44.4%). Differences in cleft types and surgeons were not associated with the distribution of patients in each cluster.
Conclusions: Patients with ICP exhibited characteristic morphological patterns, such as bimaxillary retrusion or severe mandibular retrusion, besides the anterior crossbite frequently found in patients with cleft lip and palate . Understanding the typical morphological characteristics could enable better diagnostic categorisation of patients with ICP, which may eventually improve orthodontic treatment planning.. |
| 4. |
Shinsaku Arai, Ami Funada, Sachiyo Hasegawa, Kaori Matsumura, Takeshi Mitsuyasu, Masaaki Sasaguri, Nobuhiro Sato, Toshiro Umezakid, Seiji Nakamura , A case of bilateral cleft lip and palate requiring long-term cannulation: A case report , Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology , https://doi.org/10.1016/j.ajoms.2020.12.006 , 33, 302-306, 2021.01, Cleft lip, with or without a cleft palate, is the most common craniofacial birth defect. Speech disorders, particularly impairment in articulation, are severe problems resulting from the velopharyngeal incom- petence associated with a cleft palate. In cases requiring prolonged tracheal cannulation further delays speech and language development, especially during the pre-verbal period of an infant. In this case report, we describe the treatment course of an infant with bilateral cleft lip and palate requiring long-term can- nulation. The patient underwent tracheotomy due to laryngotracheal stenosis after cheiloplasty at the age of 1 year. The tracheal cannula was in situ for a period of 6 years (to the age of 6 years). An intensive program of articulation and vocalization practice was performed during the period of tracheal cannula- tion. Following removal, the patient acquired almost normal speech and language functions. Coordination between several disciplines was critical for treatment to benefit the patient.. |
| 5. |
Hitosugi T, Mitsuyasu T, Yokoyama T, Cleft-lip-plate Patient with Tracheobronchomalacia: A case report and review of the literature in Japan, Journal of Plastic, Reconstructive & Anesthetic Surgery , In Press, 2020.12., 10.1016/j.jpra.2020.09.003, 2020.09. |
| 6. |
Kubota, K. Saijo, H. Hoshi, K. Arai, S. Mitsuyasu, T. Matsumura, K. Nakamura, S., Prader-Willi syndrome with a cleft palate: A case report, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 10.1016/j.ajoms.2019.11.006, 2019.11, Prader-Willi syndrome (PWS) is characterized by infantile hypotonia, hypogonadism, hyperphagia, developmental delay and mild mental retardation and characteristic
facial features caused by the lack of genes on chromosome 15q11-q13. Frequency of PWS is estimated to be 1/10,000–1/15,000 and cleft lip and/or palate
case is rare. Most PWS babies suffer from hypotonia with feeding problems and speech articulation defects, even though they have normal anatomical structure in
oral region. We report a case of PWS with cleft palate (CP).
Case: We report on a three-month-old male who was referred to our department from pediatrician of our hospital to treat a cleft in the soft palate. He had hypotonia,
feeding problems, almond-shaped eyes and bilateral cryptorchidism at birth. The chromosome test was performed and he was diagnosed as PWS. The volume of milk
feeding was improved by feeding training with age. However, when he started feeding with solid foods at 12 months old, a nasal emission was observed, so he
disliked eating. After palatoplasty performed at 18 months old, a nasal emission was disappeared and food intake was increased markedly. One year after palatoplasty,
his swallowing function was progressed and the velopharyngeal function improved to slight insufficiency.
Conclusion: In this case, it is possible that palatoplasty had an effect on not only velopharyngeal functions but also his swallowing functions.. |
| 7. |
S.N.A. Zam, T. Mitsuyasu, S. Kanda, S. Kawano, S. Nakamura, Induction of apoptosis by inhibition of sonic hedgehog signalling pathway in ameloblastoma cell line: a pilot study for novel therapeutic approach, International Journal of Oral and Maxillofacial Surgery, 10.1016/j.ijom.2017.02.748, 46, 1, 221-221, 2017.03, Ameloblastoma is a benign odontogenic tumour which is charac- terised by locally invasive growth into the jaw and often recurs. The quality of life is reduced by resection of the jaw as a radi- cal treatment. Therefore, development of new treatment is eagerly anticipated.We demonstrate the necessity of the sonic hedgehog (SHH) signalling pathway in the growth of ameloblastoma. Suppression of proliferation by inhibitors of the SHH signalling pathway is possible.
Several hedgehog pathway inhibitors were used to examine. Cyclopamine and GDC-0449 (vismodegib) were used as SMO inhibitors, GANT-61 and JQ-1 as GLI inhibitors. We focused on the impact that each HH signalling pathway inhibitors have on growth in each cell line by WST-8 cell proliferation assay and BrdU uptake assay. We also examined the apoptotic cells by TUNEL assay, Annexin V assay and apoptosis related proteins (BCL2 and BAX).
Expression of SHH signalling pathway related genes and gene products were detected in AM-1 cells by immunocytochemistry. The addition of vismodegib (GDC-0449), cyclopamine and itra- conazole suppressed proliferation of AM-1 cells. Gli inhibitors, Gant-61 and JQ-1, also suppressed the proliferation of AM-1 cells. The TUNEL positive rates in the cells treated by SHH sig- nalling inhibitors were significantly higher than those in control. Annexin V positivity was significantly higher in the presence of SHH signalling inhibitors. BCL2 expression was decreased and BAX expression was increased in AM-1 cells.
Our study suggests that inhibition of SHH signalling pathway is a strong candidate of the novel treatment of ameloblastoma by growth inhibition and apoptosis induction.. |
| 8. |
SHOHEI YOSHIMOTO, HIROMITSU MORITA, Matsubara Ryota, Takeshi Mitsuyasu, Yuko Imai, 梶岡 俊一, Masahiro Yoneda, Yoshi Ito, Takao Hirofuji, Seiji Nakamura, Masato Hirata, Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone, INTERNATIONAL JOURNAL OF ONCOLOGY, 10.3892/ijo.2016.3350, 2016.01, Ameloblastoma is the most common benign odontogenic tumor in Japan. It is believed that it expands in the jaw bone through peritumoral activation of osteoclasts by receptor activator of nuclear factor kappa-B ligand (RANKL) released from the ameloblastoma, as in bone metastases of cancer cells. However, the clinical features of ameloblastoma, including its growth rate and patterns of invasion, are quite different from those of bone metastasis of cancer cells, suggesting that different underlying mechanisms are involved.
Therefore, in the present study, we examined the possible mechanisms underlying the invasive expansion of ameloblastoma in the jaw bone. Expression levels of RANKL assessed
by western blotting were markedly lower in ameloblastoma (AM-1) cells than in highly metastatic oral squamous cell carcinoma (HSC-3) cells. Experiments coculturing mouse macrophages (RAW264.7) with AM-1 demonstrated low osteoclastogenic activity, as assessed by tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cell formation, probably because of low release of RANKL, whereas cocultures of RAW264.7 with HSC-3 cells exhibited very high osteoclastogenic activity. Thus, RANKL release from AM-1 appeared to be too low to generate osteoclasts. However, AM-1 cultured directly on calcium phosphate-coated plates formed resorption pits, and this was inhibited by application of bafilomycin A1. Furthermore, vacuolar-type H+-ATPase (V-ATPase) and H+/Cl- exchange transporter 7 (CLC-7) were detected on the surface of AM-1 cells by plasma membrane biotinylation and immunofluorescence analysis. Immunohistochemical analysis of clinical samples of ameloblastoma also showed plasma membrane-localized V-ATPase
and CLC-7 in the epithelium of plexiform, follicular and basal cell types. The demineralization activity of AM-1 was only 1.7% of osteoclasts demineralization activity, and the growth rate was 20% of human normal skin keratinocytes and HSC-3 cells. These results suggest that the slow expansion of several typical types of ameloblastomas in jaw bone is attributable to its slow growth and low demineralization ability.. |
| 9. |
Kazuhide Matsunaga, Masaaki Sasaguri, Takeshi Mitsuyasu, Masamichi OHISHI, Norifumi Nakamura, Upward Advancement of the Nasolabial Components at Unilateral Cleft Lip Repair Prevents Postoperative Long Lip, The Cleft palate-craniofacial journal, 10.1597/14-272, 2015.03, changes in nasolabial forms of patients with unilateral cleft lip who underwent primary lip repair
with or without upward advancement of the nasolabial components were compared.
Patients: Forty-three subjects (24 unilateral cleft lip and palate [UCLP] and 19 unilateral cleft
lip solely, and cleft lip and alveolus [UCL/UCLA]) who underwent primary lip repair with upward
advancement of the nasolabial components (NA group) and 30 subjects (16 UCLP and 14 UCL/
UCLA) without upward advancement (LA group) were enrolled.
Outcome Measures: Postoperative photos taken at 1 and 6 months and at 1, 2, and 3 years
were used for measuring the heights of the nasal alar base (NBH), the columellar base (CBH),
Cupid’s peak (CPH), and the upper lip (ULH). The ratios of these measurements between the
affected and unaffected sides were calculated in both groups.
Results: In the LA group, the 3-year postoperative all-items ratios of UCLP were significantly
larger than those at 1 month postoperatively, demonstrating drooping of the nasolabial tissues in
the affected side (all P , .01). Furthermore, the 3-year postoperative CPH and ULH ratio of UCL/
UCLA was significantly larger than that at 1 month postoperatively, demonstrating the long lip (P
, .01). In the NA group, the NBH, CBH, and CPH ratios of both UCLP and UCL/UCLA did not show
significant differences between 1 month and 3 years postoperatively.
Conclusion: Upward advancement of the nasolabial components prevents postoperative
long lip.. |
| 10. |
Masahiro Tezuka, Yuko Ogata, Kazuhide Matsunaga, Takeshi Mitsuyasu, Sachiyo Hasegawa, Norifumi Nakamura, Perceptual and videofluoroscopic analyses of relation between backed articulation and velopharyngeal closure following cleft palate repair, Oral Science International, 10.1016/S1348-8643(14)00009-3, 11, 2, 60-67, 2014.05, Purpose: Perceptual and videofluoroscopic (VF) analyses were performed to analyze velopharyngeal (VP)
closure motions and tongue backing movement in subjects with postalveolar, palatal, and velar backed
articulation (BA).
Materials and methods: For perceptual analysis, the timing of the appearance of BA and the VP closure
level of 22 children with BA following palatal repair were compared to those of 17 subjects with normal
articulation, 17 subjects with lateral articulation, and 11 subjects with glottal stop. For VF analysis, 16
subjects with BA and two healthy adult males as references were enrolled. On VF images, the proportions
of the time required to complete VP closure and the duration of articulation (VPC/DA) were recorded and
then analyzed based on the various degrees of tongue backing movement.
Results: The appearance of BA was recognized just after the acquisition of VP closure, and it was later than
that of glottal stop and earlier than lateral articulation. On VF images, VP closure was achieved before
tongue movement in healthy individuals, but after tongue movement in BA subjects. VPC/DA on articulation
of both /ta/ and /sa/ were significantly smaller for healthy individuals than for BA subjects (P The timing of the complete VP closure approached that of articulation when the site of articulation shifted
posteriorly (P Conclusions: BA may result from precedent tongue backing movement before the completion of VP closure,
as a process that may assist the VP closure motion for articulation.. |
| 11. |
Nakao Yu, Takeshi Mitsuyasu, Shintaro Kawano, Norifumi Nakamura, Shiori Kanda, Seiji Nakamura, Fibroblast growth factors 7 and 10 are involved in ameloblastoma proliferation via the mitogen-activated protein kinase pathway, INTERNATIONAL JOURNAL OF ONCOLOGY 43: 1377-1384, 2013, 10.3892/ijo.2013.2081, 43, 5, 1377-1384, 2013.11, Ameloblastoma is an epithelial benign tumor of the odontogenic apparatus and its growth mechanisms are not well understood. Fibroblast growth factor (FGF) 3, FGF7 and FGF10, which are expressed by the neural crest-derived ectomesenchymal cells, induce the proliferation of odontogenic epithelial cells during tooth development. Therefore, we examined the expression and function of these FGFs in ameloblastoma. We examined 32 cases of ameloblastoma as well as AM-1 cells (an ameloblastoma cell line) and studied the expression of FGF3, FGF7, FGF10 and their specific receptors, namely, FGF receptor (FGFR) 1 and FGFR2. Proliferation, mitogen-activated protein kinase (MAPK) signaling and PI3K signaling were examined in AM-1 cells after the addition of FGF7, FGF10 and these neutralizing antibodies. The expression of FGF7, FGF10, FGFR1 and FGFR2 was detected in ameloblastoma cells and AM-1 cells, while that of FGF3 was not. FGF7 and FGF10 stimulated AM-1 cell proliferation and phosphorylation of p44/42 MAPK. However, Akt was not phosphorylated. Blocking the p44/42 MAPK pathway by using a specific mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitor (U0126) completely neutralized the effects of FGF7 and FGF10 on AM-1 cell proliferation. However, Anti FGF7 and FGF10 neutralizing antibodies did not decrease cell proliferation and MAPK phosphorylation of AM-1 cells. These results suggested that FGF7 and FGF10 are involved in the proliferation of ameloblastoma cells through the MAPK pathway.. |
| 12. |
Akira Suzuki, Masaaki Sasaguri, Kenji Hiura, Atsushi Yasunaga, Takeshi Mitsuyasu, Yasutaka Kubota, Tomohiro Ninomiya, Yasuharu TAKENOSHITA, Can Occlusal Evaluation of Children With Unilateral Cleft Lip and Palate Help Determine Future Maxillofacial Morphology?, The Cleft Palate-Craniofacial Journal, 10.1597/12-103, in press, 2013.10, Objective: To investigate the change in occlusal evaluations from the 5-year-olds' index to the Goslon Yardstick and to compare the relationship between the evaluations and maxillofacial growth in patients with complete unilateral cleft lip and palate (UCLP).
Design: A prospective longitudinal study.
Subjects: The sample consisted of 85 patients with complete UCLP who underwent surgery from 1969 to 1994 and were treated at the Kyushu University Hospital in Fukuoka, Japan. Subjects had two serial dental casts performed at the ages of 5 and 10 years. Furthermore, each patient had lateral cephalographs taken at the age of 5 years, 76 of 85 subjects had films taken at the age of 10 years, and 54 subjects also had lateral cephalograms taken after the age of 15 years.
Methods: Every dental cast was evaluated by the 5-year-olds' index and the Goslon Yardstick, respectively. The lateral cephalographs were traced and digitized, and angular dimensions were calculated. Outcomes were compared using Spearman's rank-order correlation analysis and the Kruskal-Wallis analysis.
Results and Conclusion: Dental arch relationships were evaluated and rated as 2.96 in the 5-year-olds' index and 2.85 in the Goslon Yardstick, respectively. Both groupings showed a significant relationship, and they showed no change in 42.3% of subjects, improvement in 35.3%, and deterioration in 22.3%. Two occlusal groupings and maxillofacial morphology on the cephalographs indicated that the grouping reflected the anteroposterior position of the mandible. Moreover, both groupings showed some relation to previous maxillofacial growth, but they did not show any relationship with future growth. The Goslon Yardstick may not predict maxillofacial morphology in adulthood.. |
| 13. |
Shiori Kanda, Takeshi Mitsuyasu, Nakao Yu, Shintaro Kawano, Yuichi Goto, Ryota Matsubara, Seiji Nakamura, Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma, INTERNATIONAL JOURNAL OF ONCOLOGY 43: 695-702, 2013, 43, 695-702, INTERNATIONAL JOURNAL OF ONCOLOGY 43: 695-702, 2013, 2013.07, Sonic hedgehog (SHH) signaling pathway is crucial to growth and patterning during organogenesis. Aberrant activation of the SHH signaling pathway can result in tumor formation. We examined the expression of SHH signaling molecules and investigated the involvement of the SHH pathway in the proliferation of ameloblastoma, the most common benign tumor of the jaws. We used immunohistochemistry on ameloblastoma specimens and immunocytochemistry and reverse transcription-PCR on the ameloblastoma cell line AM-1. We also used the inhibitors of SHH signaling, SHH neutralizing antibody and cyclopamine, to assess the effects of SHH on the proliferation of AM-1 cells. We detected expression of SHH, patched, GLI1, GLI2 and GLI3 in the ameloblastoma specimens and AM-1 cells. The proliferation of these cells was significantly inhibited in the presence of SHH neutralizing antibody or cyclopamine; this was confirmed by BrdU incorporation assays. Furthermore, in the presence of SHH neutralizing antibody, nuclear translocation of GLI1 and GLI2 was abolished, apoptosis was induced, BCL-2 expression decreased and BAX expression increased. Our results suggest that the SHH signaling pathway is constitutively active in ameloblastoma and plays an anti-apoptotic role in the proliferation of ameloblastoma cells through autocrine loop stimulation.. |
| 14. |
Eiji Mitate∗, Masaaki Sasaguri, Kazunari Oobu, Takeshi Mitsuyasu, Akihiko Tanaka, Takahiro Kiyosue, Seiji Nakamura, Postoperative changes of blood flow in free microvascular flaps transferred for reconstruction of oral cavity: Effects of intravenous infusion of prostaglandin E1, Asian Journal of Oral and Maxillofacial Surgery, 2011.05. |
| 15. |
Laifa Hendarmin, Shintaro Kawano, Daigo Yoshiga, Ferry Sandra, Takeshi Mitsuyasu, Yu Nakao, Yoshinori Higuchi, Norifumi Nakamura, Seiji Nakamura, An anti-apoptotic role of NF-kB in TNFa-induced apoptosis in ameloblastoma cell line, Oral Science International, November 2008, p96-103, 2008.11. |
| 16. |
Nakayama E, Okamura K, Mitsuyasu T, Kawazu T, Nakamura N, Nakamura S, Yoshiura K., A newly developed interventional sialendoscope for a completely nonsurgical sialolithectomy using intracorporeal electrohydraulic lithotripsy., J Oral Maxillofac Surg. 2007 Jul;65(7):1402-5., 65(7):1402-5, 2007.07. |
| 17. |
Nakamura N, Mitsuyasu T, Ohishi M., Endoscopic removal of a dental implant displaced into the maxillary sinus: technical note., Int J Oral Maxillofac Surg., 10.1054/ijom.2003.0470, 33, 2, 195-197, 33(2):195-7, 2004.03. |
| 18. |
Nakamura N, Mitsuyasu T, Mitsuyasu Y, Taketomi T, Higuchi Y, Ohishi M., Marsupialization for odontogenic keratocysts: long-term follow-up analysis of the effects and changes in growth characteristics., Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 10.1067/moe.2002.128022, 94, 5, 543-553, 94(5):543-53, 2002.11. |
| 19. |
Harada H, Mitsuyasu T, Toyono T, Toyoshima K., Epithelial stem cells in teeth., Odontology, 90(1):1-6, 2002.09. |
| 20. |
Nakamura N, Higuchi Y, Mitsuyasu T, Sandra F, Ohishi M., Comparison of long-term results between different approaches to ameloblastoma., Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 10.1067/moe.2002.119517, 93, 1, 13-20, 93(1):13-20., 2002.01. |
| 21. |
Sandra F, Nakamura N, Mitsuyasu T, Shiratsuchi Y, Ohishi M., Two relatively distinct patterns of ameloblastoma: an anti-apoptotic proliferating site in the outer layer (periphery) and a pro-apoptotic differentiating site in the inner layer (centre)., Histopathology, 10.1046/j.1365-2559.2001.01138.x, 39, 1, 93-98, 39(1):93-8, 2001.07. |
| 22. |
Nakamura N, Mitsuyasu T, Higuchi Y, Sandra F, Ohishi M., Growth characteristics of ameloblastoma involving the inferior alveolar nerve: a clinical and histopathologic study., Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 10.1067/moe.2001.113110, 91, 5, 557-562, 91(5):557-62., 2001.05. |
| 23. |
Sandra F, Mitsuyasu T, Nakamura N, Shiratsuchi Y, Ohishi M., Immunohistochemical evaluation of PCNA and Ki-67 in ameloblastoma., Oral Oncol., 10.1016/S1368-8375(00)00079-8, 37, 2, 193-198, 37(2):193-8., 2001.02. |
| 24. |
Liao J, Mitsuyasu T, Yamane K, Ohishi M., Telomerase activity in oral and maxillofacial tumors., Oral Oncol., 10.1016/S1368-8375(00)00013-0, 36, 4, 347-352, 36(4):347-52., 2000.07. |
| 25. |
Harada H, Mitsuyasu T, Seta Y, Maruoka Y, Toyoshima K, Yasumoto S., Overexpression of bcl-2 protein inhibits terminal differentiation of oral keratinocytes in vitro., J Oral Pathol Med., 27(1):11-7., 1998.01. |
| 26. |
Harada H, Mitsuyasu T, Nakamura N, Higuchi Y, Toyoshima K, Taniguchi A, Yasumoto S., Establishment of ameloblastoma cell line, AM-1., J Oral Pathol Med., 27, 5, 207-212, 27(5):207-12., 1998.05. |
| 27. |
Mitsuyasu T, Harada H, Higuchi Y, Kimura K, Nakamura N, Katsuki T, Kubota E, Toyoshima K, Ohishi M., Immunohistochemical demonstration of bcl-2 protein in ameloblastoma., J Oral Pathol Med., 10.1111/j.1600-0714.1997.tb00228.x, 26, 8, 345-348, 26(8):345-8., 1997.09. |
| 28. |
Maruoka Y, Harada H, Mitsuyasu T, Seta Y, Kurokawa H, Kajiyama M, Toyoshima K., Keratinocytes become terminally differentiated in a process involving programmed cell death., Biochem Biophys Res Commun., 29;238(3):886-90., 1997.09. |
