九州大学 研究者情報
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基本情報 研究活動 教育活動 社会活動 病院臨床活動
加藤 隆弘(かとう たかひろ) データ更新日:2019.08.30

講師 /  九州大学病院 精神科神経科 医学研究院 精神病態医学


主な研究テーマ
気分障害
ひきこもり
ミクログリア
神経炎症
自殺予防
キーワード:気分障害、ひきこもり、ミクログリア、神経炎症、自殺予防
2008.04~2018.08.
従事しているプロジェクト研究
AMED融合脳
2016.04~2018.08, 代表者:加藤隆弘, 九州大学, 日本
うつ病のミクログリア仮説に基づく画期的な診断治療マーカーの開発.
研究業績
主要原著論文
1. Takahiro Kato, Shigenobu Kanba, Alan R. Teo, Hikikomori 
Multidimensional understanding, assessment, and future international perspectives, Psychiatry and Clinical Neurosciences, 10.1111/pcn.12895, 73, 8, 427-440, 2019.08, [URL], Hikikomori, a severe form of social withdrawal, has long been observed in Japan mainly among youth and adolescents since around the 1970s, and has been especially highlighted since the late 1990s. Moreover, hikikomori-like cases have recently been reported in many other countries. Hikikomori negatively influences not only the individual's mental health and social participation, but also wider education and workforce stability, and as such is a novel urgent global issue. In this review, we introduce the history, definition, diagnostic evaluation, and interventions for hikikomori and also the international prevalence of hikikomori outside Japan. We propose a hypothesis regarding the globalization of hikikomori based on domestic and international perspectives. In addition, we introduce our latest assessment system for hikikomori (including the latest version of the ‘proposed diagnostic criteria of hikikomori for the future DSM/ICD diagnostic systems’) and propose therapeutic strategies, including family approaches and individualized therapies. Finally, we present future challenges that may lead to solutions for an internationalized hikikomori..
2. Takahiro Kato, Ryoko Katsuki, Hiroaki Kubo, Norihiro Shimokawa, Mina Sato-Kasai, Kohei Hayakawa, Nobuki Kuwano, Wakako Umene-Nakano, Masaru Tateno, Daiki Setoyama, Dongchon Kang, Motoki Watabe, Shinji Sakamoto, Alan R. Teo, Shigenobu Kanba, Development and validation of the 22-item Tarumi's Modern-Type Depression Trait Scale
Avoidance of Social Roles, Complaint, and Low Self-Esteem (TACS-22), Psychiatry and Clinical Neurosciences, 10.1111/pcn.12842, 73, 8, 448-457, 2019.08, [URL], Aim: Understanding premorbid personality is important, especially when considering treatment selection. Historically, the premorbid personality of patients with major depression in Japan was described as Shuchaku-kishitsu [similar to Typus melancholicus], as proposed by Shimoda in the 1930s. Since around 2000, there have been increased reports in Japan of young adults with depression who have had premorbid personality differing from the traditional type. In 2005, Tarumi termed this novel condition ‘dysthymic-type depression,’ and more recently the condition has been called Shin-gata/Gendai-gata Utsu-byo [modern-type depression (MTD)]. We recently developed a semi-structured diagnostic interview to evaluate MTD. Development of a tool that enables understanding of premorbid personality in a short time, especially at the early stage of treatment, is desirable. The object of this study was to develop a self-report scale to evaluate the traits of MTD, and to assess the scale's psychometric properties, diagnostic accuracy, and biological validity. Methods: A sample of 340 participants from clinical and community settings completed measures. Psychometric properties were assessed with factor analysis. Diagnostic accuracy of the MTD traits was compared against a semi-structured interview. Results: The questionnaire contained 22 items across three subscales, thus we termed it the 22-item Tarumi's Modern-Type Depression Trait Scale: Avoidance of Social Roles, Complaint, and Low Self-Esteem (TACS-22). Internal consistency, test–retest reliability, and convergent validity were all satisfactory. Among patients with major depression, the area under the curve was 0.757 (sensitivity of 63.1% and specificity of 82.9%) and the score was positively correlated with plasma tryptophan. Conclusion: The TACS-22 possessed adequate psychometric properties and diagnostic accuracy in an initial sample of Japanese adults. Additional research on its ability to support clinical assessment of MTD is warranted..
3. Lin SK*, Lin YF, Yang SY, He YL, Kato TA, Hayakawa K, Park YC, Sim K, Chiu HFK, Xiang YT, Chong MY, Tan CH, Inada T, Shinfuku N, Comparison of the Defined Daily Dose and Chlorpromazine Equivalent Methods in Antipsychotic Drug Utilization in Six Asian Countries, Neuropsychiatry, DOI: 10.4172/Neuropsychiatry.1000527 , 8, 6, 1847-1852, 2018.12.
4. Yukako Nakagami, Hiroaki Kubo, Ryoko Katsuki, Tomomichi Sakai, Genichi Sugihara, Chisako Naito, Hiroyuki Oda, Kohei Hayakawa, Yuriko Suzuki, Daisuke Fujisawa, Naoki Hashimoto, Keiji Kobara, Tetsuji Cho, Hironori Kuga, Kiyoshi Takao, Yoko Kawahara, Yumi Matsumura, Toshiya Murai, Koichi Akashi, Shigenobu Kanba, Kotaro Otsuka, Takahiro Kato, Development of a 2-h suicide prevention program for medical staff including nurses and medical residents
A two-center pilot trial, Journal of Affective Disorders, 10.1016/j.jad.2017.08.074, 225, 569-576, 2018.08, [URL], Background Suicide is a crucial global health concern and effective suicide prevention has long been warranted. Mental illness, especially depression is the highest risk factor of suicide. Suicidal risk is increased in people not only with mental illness but also with physical illnesses, thus medical staff caring for physically-ill patients are also required to manage people with suicidal risk. In the present study, we evaluated our newly developed suicide intervention program among medical staff. Methods We developed a 2-h suicide intervention program for medical staff, based on the Mental Health First Aid (MHFA), which had originally been developed for the general population. We conducted this program for 74 medical staff members from 2 hospitals. Changes in knowledge, perceived skills, and confidence in early intervention of depression and suicide-prevention were evaluated using self-reported questionnaires at 3 points; pre-program, immediately after the program, and 1 month after program. Results This suicide prevention program had significant effects on improving perceived skills and confidence especially among nurses and medical residents. These significant effects lasted even 1 month after the program. Limitations Design was a single-arm study with relatively small sample size and short-term follow up. Conclusions The present study suggests that the major target of this effective program is nurses and medical residents. Future research is required to validate the effects of the program with control groups, and also to assess long-term effectiveness and actual reduction in suicide rates..
5. Tateno M*, Tateno Y, Kamikobe C, Monden R, Sakaoka O, Kanazawa J, Kato TA, Saito T, Internet addiction and ADHD traits among female college students in Japan, Journal of the Korean Academy of Child and Adolescent Psychiatry, doi: org/10.5765/jkacap.180011, 29, 3, 144-148, 2018.07.
6. Alan R. Teo, Jason I. Chen, Hiroaki Kubo, Ryoko Katsuki, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Wakako Umene-Nakano, James E. Aikens, Shigenobu Kanba, Takahiro A Kato, Development and validation of the 25-item Hikikomori Questionnaire (HQ-25), Psychiatry and Clinical Neurosciences, 10.1111/pcn.12691, 2018.05, [URL], Aim: Hikikomori, a form of severe social withdrawal, is an emerging issue in mental health, for which validated measurement tools are lacking. The object was to develop a self-report scale of hikikomori, and assess its psychometric properties and diagnostic accuracy. Methods: A sample of 399 participants from clinical and community settings completed measures. Psychometric properties were assessed with factor analysis; diagnostic accuracy was compared against a semi-structured diagnostic interview. Results: The Hikikomori Questionnaire contained 25 items across three subscales representing socialization, isolation, and emotional support. Internal consistency, test-retest reliability, and convergent validity were all satisfactory. The area under the curve was 0.86 (95% confidence interval, 0.80-0.92). A cut-off score of 42 (out of 100) was associated with a sensitivity of 94%, specificity of 61%, and positive predictive value of 17%. Conclusion: The 25-item Hikikomori Questionnaire (HQ-25) possesses robust psychometric properties and diagnostic accuracy in an initial sample of Japanese adults. Additional research on its psychometric properties and ability to support clinical assessment of hikikomori is warranted..
7. Nobuki Kuwano, Takahiro Kato, Daiki Setoyama, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Junji Kishimoto, Dongchon Kang, Shigenobu Kanba, Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder
An exploratory pilot case-control study, Journal of Affective Disorders, 10.1016/j.jad.2018.01.014, 231, 74-82, 2018.04, [URL], Background: Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in the pathophysiology of MDD. However, there have been limited studies investigating these blood biomarkers in first-episode drug-naïve MDD, which are particularly important for early intervention in depression. Methods: As an exploratory pilot case-control study, we examined the above blood biomarkers, and analyzed how these biomarkers are associated with clinical variables in first-episode drug-naïve MDD patients, based on metabolome/lipidome analysis. Results: Plasma tryptophan and kynurenine levels were significantly lower in MDD group (N = 15) compared to healthy controls (HC) group (N = 19), and plasma tryptophan was the significant biomarker to identify MDD group (area under the curve = 0.740). Lower serum high density lipoprotein-cholesterol (HDL-C) was the predictive biomarker for severity of depression in MDD group (R2 = 0.444). Interestingly, depressive symptoms were variously correlated with plasma tryptophan-kynurenine and lipid related metabolites. Moreover, plasma tryptophan-kynurenine metabolites and cholesteryl esters (CEs) were significantly correlated in MDD group, but not in HC group. Limitations: This study had small sample size, and we did not use the multiple test correction. Conclusions: This is the first study to suggest that not only tryptophan-kynurenine metabolites but also HDL-C and CEs are important blood biomarkers for first-episode drug-naïve MDD patients. The present study sheds new light on early intervention in clinical practice in depression, and further clinical studies especially large-scale prospective studies are warranted..
8. Kohei Hayakawa, Takahiro Kato, Motoki Watabe, Alan R. Teo, Hideki Horikawa, Nobuki Kuwano, Norihiro Shimokawa, Mina Sato-Kasai, Hiroaki Kubo, Masahiro Ohgidani, Noriaki Sagata, Hiroyuki Toda, Masaru Tateno, Naotaka Shinfuku, Junji Kishimoto, Shigenobu Kanba, Blood biomarkers of Hikikomori, a severe social withdrawal syndrome, Scientific Reports, 10.1038/s41598-018-21260-w, 8, 1, 2018.02, [URL], Hikikomori, a severe form of social withdrawal syndrome, is a growing social issue in Japan and internationally. The pathophysiology of hikikomori has not yet been elucidated and an effective treatment remains to be established. Recently, we revealed that avoidant personality disorder is the most common comorbidity of hikikomori. Thus, we have postulated that avoidant personality is the personality underpinning hikikomori. First, we herein show relationships between avoidant personality traits, blood biomarkers, hikikomori-related psychological features, and behavioural characteristics assessed by a trust game in non-hikikomori volunteers. Avoidant personality traits were negatively associated with high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) in men, and positively associated with fibrin degeneration products (FDP) and high sensitivity C-reactive protein (hsCRP) in women. Next, we recruited actual individuals with hikikomori, and compared avoidant personality traits, blood biomarkers, and psychological features between individuals with hikikomori and age-matched healthy controls. Individuals with hikikomori had higher avoidant personality scores in both sexes, and showed lower serum UA levels in men and lower HDL-C levels in women compared with healthy controls. This is the first report showing possible blood biomarkers for hikikomori, and opens the door to clarify the underlying biological pathophysiology of hikikomori..
9. Takahiro Kato, Shigenobu Kanba, Alan R. Teo, Hikikomori
experience in Japan and international relevance, World Psychiatry, 10.1002/wps.20497, 17, 1, 105-106, 2018.02, [URL], 九州大学を拠点するひきこもり国際共同ネットワークによる成果の概要をまとめた報告である。.
10. Noriaki Sagata, Takahiro Kato, Shin Ichi Kano, Masahiro Ohgidani, Norihiro Shimokawa, Mina Sato-Kasai, Kohei Hayakawa, Nobuki Kuwano, Ashley M. Wilson, Koko Ishizuka, Shiori Kato, Takeshi Nakahara, Makiko Nakahara-Kido, Daiki Setoyama, Yasunari Sakai, Shoichi Ohga, Masutaka Furue, Akira Sawa, Shigenobu Kanba, Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients
A pilot study, Scientific Reports, 10.1038/s41598-017-14440-7, 7, 1, 2017.12, [URL], Direct conversion technique to produce induced-neuronal (iN) cells from human fibroblasts within 2 weeks is expected to discover unknown neuronal phenotypes of neuropsychiatric disorders. Here, we present unique gene expression profiles in iN cells from patients with neurofibromatosis type 1 (NF1), a single-gene multifaceted disorder with comparatively high co-occurrence of autism spectrum disorder (ASD). Microarray-based transcriptomic analysis on iN cells from male healthy controls and male NF1 patients (NF1-iN cells) revealed that 149 genes expressions were significantly different (110 upregulated and 39 downregulated). We validated that mRNA of MEX3D (mex-3 RNA binding family member D) was lower in NF1-iN cells by real-time PCR with 12 sex-mixed samples. In NF1-iN cells on day 14, higher expression of FOS mRNA was observed with lower expression of MEX3D mRNA. Interestingly, BCL2 mRNA was higher in NF1-iN cells on day 5 (early-period) but not on day 14. Our data suggest that aberrant molecular signals due to NF1 mutations may disturb gene expressions, a subset of which defines continuum of the neuronal phenotypes of NF1 with ASD. Further translational studies using induced pluripotent stem (iPS) cell-derived neuronal cells are needed to validate our preliminary findings especially confirming meanings of analysis using early-period iN cells..
11. Masahiro Ohgidani, Takahiro Kato*, Masako Hosoi, Tsuda Makoto, Kohei Hayakawa, Chie Hayaki, Rie Iwaki, Noriaki Sagata, Ryota Hashimoto, Kazuhide Inoue, Nobuyuki Sudo, Shigenobu Kanba, Fibromyalgia and microglial TNF-α
Translational research using human blood induced microglia-like cells, Scientific Reports, 10.1038/s41598-017-11506-4, 7, 1, 2017.12, [URL], Fibromyalgia is a refractory disease characterized by chronic intractable pain and psychological suffering, the cause of which has not yet been elucidated due to its complex pathology. Activation of immune cells in the brain called microglia has attracted attention as a potential underlying pathological mechanism in chronic pain. Until recently, however, technological and ethical considerations have limited the ability to conduct research using human microglia. To overcome this limitation, we have recently developed a technique to create human-induced microglia-like (iMG) cells from human peripheral blood monocytes. In this study, we created the iMG cells from 14 patients with fibromyalgia and 10 healthy individuals, and compared the activation of iMG cells between two groups at the cellular level. The expression of tumor necrosis factor (TNF)-α at mRNA and protein levels significantly increased in ATP-stimulated iMG cells from patients with fibromyalgia compared to cells from healthy individuals. Interestingly, there was a moderate correlation between ATP-induced upregulation of TNF-α expression and clinical parameters of subjective pain and other mental manifestations of fibromyalgia. These findings suggest that microglia in patients with fibromyalgia are hypersensitive to ATP. TNF-α from microglia may be a key factor underlying the complex pathology of fibromyalgia..
12. Takahiro Kato*, Shigenobu Kanba, Modern-type depression as an "adjustment" disorder in Japan
The intersection of collectivistic society encounteringanindividualisticperformance-basedsystem, American Journal of Psychiatry, 10.1176/appi.ajp.2017.17010059, 174, 11, 1051-1053, 2017.11, [URL], うつ病の現代における課題に関して、特に適応の障害という観点から論じた論文である。.
13. Takahiro Kato, Aye M. Myint, Johann Steiner, Editorial: Minding glial cells in the novel understandings of mental illness, Frontiers in Cellular Neuroscience, 10.3389/fncel.2017.00048, 11, 2017.02, [URL].
14. Masahiro Ohgidani, Takahiro Kato, Yoshinori Haraguchi, Toshio Matsushima, Yoshito Mizoguchi, Toru Murakawa-Hirachi, Noriaki Sagata, Akira Monji, Shigenobu Kanba, Microglial CD206 gene has potential as a state marker of bipolar disorder, Frontiers in Immunology, 10.3389/fimmu.2016.00676, 7, JAN, 2017.01, [URL], The pathophysiology of bipolar disorder, especially the underlying mechanisms of the bipolarity between manic and depressive states, has yet to be clarified. Microglia, immune cells in the brain, play important roles in the process of brain inflammation, and recent positron emission tomography studies have indicated microglial overactivation in the brain of patients with bipolar disorder. We have recently developed a technique to induced microglia-like (iMG) cells from peripheral blood (monocytes). We introduce a novel translational approach focusing on bipolar disorder using this iMG technique. We hypothesize that immunological conditional changes in microglia may contribute to the shift between manic and depressive states, and thus we herein analyzed gene profiling patterns of iMG cells from three patients with rapid cycling bipolar disorder during both manic and depressive states, respectively. We revealed that the gene profiling patterns are different between manic and depressive states. The profiling pattern of case 1 showed that M1 microglia is dominant in the manic state compared to the depressive state. However, the patterns of cases 2 and 3 were not consistent with the pattern of case 1. CD206, a mannose receptor known as a typical M2 marker, was significantly downregulated in the manic state among all three patients. This is the first report to indicate the importance of shifting microglial M1/M2 characteristics, especially the CD206 gene expression pattern between depressive and manic states. Further translational studies are needed to dig up the microglial roles in the underlying biological mechanisms of bipolar disorder..
15. Takahiro A. Kato, Can “Pokémon GO” rescue shut-ins (hikikomori) from their isolated world?, Psychiatry and Clinical Neurosciences, 2016.11.
16. Ohgidani M, Kato TA*, Sagata N, Hayakawa K, Shimokawa N, Sato-Kasai M, Kanba S, TNF-α from hippocampal microglia directly induces working memory deficits by acute stress in mice, Brain, Behavior, and Immunity, 10.1016/j.bbi.2015.08.022. , 55, 17-24, 2016.07.
17. Maruo, J, Haraguchi, Y, Tateishi H, Noguchi T, Mizoguchi Y, Kato TA, Kawashima T, Monji A, Abnormal behaviours during pramipexole treatment for Cotard's syndrome: a case report, Psychogeriatrics , 10.1111/psyg.12148. , 16, 4, 283-286, 2016.07.
18. Haraguchi Y*, Mizoguchi Y, Noguchi T, Arai T, Fukuyaa J, Kato TA, Kawashima T, Monji A*, A patient with Alzheimer’s disease complicated by elderly-onset Cushing’s syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia, Psychogeriatrics , 10.1111/psyg.12146., 16, 4, 274-276, 2016.07.
19. Kato TA*, Kanba S, Teo AR*, A 39-Year-Old “Adultolescent”: Understanding Social Withdrawal in Japan. Perspectives in Global Mental Health, American Journal of Psychiatry, 10.1176/appi.ajp.2015.15081034., 173, 2, 112-114, 2016.02.
20. Tateishi H, Hirachi T, Maruo J, Haraguchi Y, Noguchi T, Mizoguchi Y, Kato TA, Kawashima T, Monji A, Neurocognitive Disorders in Chronic Kidney Disease: A Case Report and Literature Review, Psychosomatics, 10.1016/j.psym.2015.07.007., 57, 1, 107-12, 2016.01.
21. Kato TA*, Kanba S, Boundless syndromes in modern society – An interconnected world producing novel psychopathology in the 21st century, Psychiatry and Clinical Neuroscience, 10.1111/pcn.12368. , 70, 1, 1-2, 2016.01.
22. Kato TA*, Hashimoto R, Hayakawa K, Kubo H, Watabe M, Teo AR, Kanba S, The multidimensional anatomy of “modern type depression” in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5. Frontier Review, Psychiatry and Clinical Neuroscience, 10.1111/pcn.12358., 70, 1, 7-23, 2016.01.
23. Hashimoto N*, Suzuki Y, Kato TA, Fujisawa D, Sato R, Aoyama-Uehara K, Fukasawa M, Asakura S, Kusumi I, Otsuka K, The effectiveness of suicide prevention gatekeeper-training for university administrative staff in Japan, Psychiatry and Clinical Neuroscience, 10.1111/pcn.12358. , 70, 1, 62-70, 2016.01.
24. Hirachi T, Ishii H, Tada Y, Noguchi T, Haraguchi Y, Tateishi H, Mizoguchi Y, Kato TA, Kawashima T, Monji A*, Mania occurring during systemic lupus erythematosus relapse and its amelioration on clinical and neuroimaging follow-up, Lupus, 10.1177/0961203315570161., 24, 9, 990-993, 2015.08.
25. Teo AR, Stufflebam K, Saha S, Fetters MD, Tateno M, Kanba S, Kato TA, Psychopathology Associated with Social Withdrawal: Idiopathic and Co-Morbid Presentations, Psychiatry Research, 10.1016/j.psychres.2015.04.033., 228, 1, 182-183, 2015.07.
26. Ohgidani M, Kato TA*, Kanba S, Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: A novel translational research tool for psychiatric disorders, Frontiers in Cellular Neuroscience, 10.3389/fncel., 9, 184, 2015.05.
27. Guest PC, Iwata K, Kato TA, Steiner J, Schmitt A, Turck CW, Martins-de-Souza D* (Contributed equally), MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia, Frontiers in Cellular Neuroscience, 10.3389/fncel.2015.00180. , 9, 180, 2015.05.
28. Watabe M*, Kato TA*, Teo AR, Horikawa H, Tateno M, Hayakawa K, Shimokawa N, Kanba S (: These authors contributed equally to this work), Relationship between trusting behaviors and psychometrics associated with social network and depression among young generation: a pilot study, PLoS ONE, 10.1371/journal.pone.0120183., 10, 4, e0120183, 2015.04.
29. Teo AR*, Fetters MD,Stufflebam S, Tateno M, Balhara YBS, Choi TY, Kanba S, Mathews CA, Kato TA*, Identification of the Hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries, International Journal of Social Psychiatry, 10.1177/0020764014535758. , 61, 1, 64-72, 2015.02.
30. Teo AR*, Kato TA, The prevalence and correlates of severe social withdrawal in Hong Kong. (Letter to the Editor) , International Journal of Social Psychiatry, 10.1177/0020764014554923. , 61, 1, 102, 2015.02.
31. Mizoguchi Y*, Kato TA, Horikawa H, Monji A, Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia, Frontiers in Cellular Neuroscience, 10.3389/fncel.2014.00370., 8, 370, 2014.11.
32. Yamamura K, Kato S, Kato TA, Mizoguchi Y, Monji A, Kanba S, Furue M, Takeuchi S, Anti-allergic mechanisms of Japanese herbal medicine, yokukansan on mast cells, Journal of Dermatology, 10.1111/1346-8138.12578. , 41, 9, 808-14, 2014.08.
33. Mizoguchi Y*, Kato TA, Seki Y, Ohgidani M, Sagata N, Horikawa H, Yamauchi Y, Sato-Kasai M, Hayakawa K, Inoue R, Kanba S, Monji A, BDNF induces sustained intracellular Ca2+ elevation through the upregulation of surface TRPC3 channels in rodent microglia, Journal of Biological Chemistry, 10.1074/jbc.M114.555334., 289, 26, 18549-18555, 2014.06.
34. Suzuki Y*, Kato TA, Sato R, Fujisawa D, Aoyama-Uehara K, Hashimoto N, Yonemoto N, Fukasawa M, Otsuka K, Effectiveness of brief suicide management training program for medical residents in Japan: A cluster randomized controlled trial. Epidemiology and Psychiatric Sciences, Epidemiology and Psychiatric Sciences, 10.1017/S2045796013000334. , 23, 2, 167-76, 2014.06.
35. Ohgidani M, Kato TA*, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S, Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease, Scientific Reports, 10.1038/srep04957., 4, 4957, 2014.05.
36. Hayakawa K, Kato TA*, Kojiro M, Monji A, Kanba S, Minocycline, a microglial inhibitor, diminishes terminal patients’ delirium? , American Journal of Geriatric Psychiatry, 10.1016/j.jagp.2013.11.003., 22, 3, 314-315, 2014.03.
37. Farooq K, Lydall GJ, Malik A, Ndetei DM; ISOSCCIP Group (including Kato TA & Kanba S), Bhugra D, ISOSCCIP Group (including Kato TA & Kanba S), Bhugra D: Why medical students choose psychiatry - a 20 country cross-sectional survey, BMC Medical Education, 10.1186/1472-6920-14-12., 14, 12, 2014.01.
38. Yoshihiro Seki, Kato TA, Monji A, Mizoguchi Y, Horikawa H, Sato-Kasai M, Yoshiga D, Kanba S, Aripiprazole and minocycline, but not haloperidol, suppress oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model., Schizophrenia Research , 151, 1-3, 20-28, 2013.12.
39. Fujisawa D*, Suzuki Y, Kato TA, Hashimoto N, Sato R, Aoyama-Uehara K, Fukasawa M, Tomita M, Kashima H, Otsuka K, Suicide intervention skills among medical residents, Academic Psychiatry, 10.1176/appi.ap.10110154., 37, 6, 402-407, 2013.11.
40. Kato TA, Watabe M, Kanba S, Neuron-glia interaction as a possible glue to translate the mind-brain gap: A novel multi-dimensional approach toward psychology and psychiatry., Frontiers in Psychiatry (Frontiers in Neuropsychiatric Imaging and Stimulation), 4, 139, 2013.10.
41. Kato TA*, Watabe M, Kanba S, Neuron-glia interaction as a possible glue to translate the mind-brain gap: A novel multi-dimensional approach toward psychology and psychiatry, Frontiers in Psychiatry (Frontiers in Neuropsychiatric Imaging and Stimulation), 10.3389/fpsyt.2013.00139., 4, 139, 2013.10.
42. Kato TA, Balhara YPS, Chawla JM, Tateno M, Kanba S, Undergraduate medical students' attitudes toward psychiatry: an international cross-sectional survey between India and Japan., International Review of Psychiatry, 25, 4, 378-384, 2013.09.
43. Kato TA*, Balhara YPS*, Chawla JM, Tateno M, Kanba S, Undergraduate medical students' attitudes toward psychiatry: an international cross-sectional survey between India and Japan, International Review of Psychiatry, 10.3109/09540261.2013.812959., 25, 4, 378-384, 2013.08.
44. Kato TA*, Hayakawa K, Monji A, Kanba S, Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders and Microglia, Frontiers in Integrative Neuroscience, 10.3389/fnint.2013.00053. , 7, 53, 2013.07.
45. Kato TA, Hayakawa K, Monji A, Kanba S, Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders and Microglia., Frontiers in Integrative Neuroscience, 10.3389/fnint.2013.00053, 7, 53, 2013.07.
46. Kato TA*, Kanba S, Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach, Frontiers in Human Neuroscience, 10.3892/or.2013.2354. , 7, 13, 2013.06.
47. Monji A*, Kato TA, Mizoguchi Y, Horikawa H, Seki Y, Kasai M, Yamauchi Y, Yamada S, Kanba S, Neuroinflammation in schizophrenia especially focused on the role of microglia, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 10.1016/j.pnpbp.2011.12.002. , 42, 115-121, 2013.04.
48. Watabe M, Kato TA, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsumi H, Kanba S, Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange., Scientific Reports 3, 1685, 2013, 3, 1683, 2013.04.
49. Kato A. Takahiro, Kanba Shigenobu, Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach., Frontiers in Human Neuroscience, 10.3389/fnhum.2013.00013, 7, 13, [http://www.frontiersin.org/Human_Neuroscience/10.3389/fnhum.2013.00013/abstract], 2013.02, The unconscious mind-brain relationship remains unresolved. From the perspective of neuroscience, neuronal networks including synapses have been dominantly believed to play crucial roles in human mental activities, while glial contribution to mental activities has long been ignored. Recently, it has been suggested that microglia, glial cells with immunological/inflammatory functions, play important roles in psychiatric disorders. Newly revealed microglial roles, such as constant direct contact with synapses even in the normal brain, have defied the common traditional belief that microglia do not contribute to neuronal networks. Recent human neuroeconomic investigations with healthy volunteers using minocycline, an antibiotic with inhibitory effects on microglial activation, suggest that microglia may unconsciously modulate human social behaviors as "noise." We herein propose a novel unconscious mind structural system in the brain centering on microglia from a neuropsychoanalytic approach. At least to some extent, microglial activation in the brain may activate unconscious drives as "psychological immune memory/reaction" in the mind, and result in various emotions, traumatic reactions, psychiatric symptoms including suicidal behaviors, and (psychoanalytic) transference during interpersonal relationships. Microglia have the potential to bridge the huge gap between neuroscience, biological psychiatry, psychology and psychoanalysis as a key player to connect the conscious and the unconscious world..
50. Kato TA, Yamauchi Y, Horikawa H, Monji A, Mizoguchi Y, Seki Y, Hayakawa K, Utsumi H, Kanba S, Neurotransmitters, Psychotropic Drugs and Microglia: Clinical Implications for Psychiatry, Current Medicinal Chemistry, 20, 3, 331-344, 2013.01.
51. Kato TA*, Watabe M*, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsumi H, Kanba S [* These authors equally contributed to this work.], Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors., PLoS ONE, 7, 7, e40461, 2012.07.
52. Watabe M*, Kato TA*, Monji A, Horikawa H, Kanba S [* These authors equally contributed to this work.], Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?, Psychopharmacology, 220.0, 3.0, 551-557, 2012.04.
53. Kato TA, Shinfuku N, Sartorius N, Kanba S, Are Japan's hikikomori and depression in young people spreading abroad? [Correspondence], The Lancet, 378.0, 9796.0, 1070.0, 2011.08, None..
54. Kato TA, Shinfuku N, Fujisawa D, Tateno M, Ishida T, Akiyama T, Sartorius N, Teo AR, Choi TY, Wand APF, Balhara YPS, Chang JPC, Chang RYF, Shadloo B, Ahmed HU, Lerthattasilp T, Umene-Nakano W, Horikawa H, Matsumoto R, Kuga H, Tanaka M, Kanba S, Introducing the Concept of Modern Depression in Japan; an International Case Vignette Survey., Journal of Affective Disorders, 135.0, 1-3, 66-76, 2011.07.
55. Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S, Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)- stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia., Schizophrenia Research, 129.0, 2−3, 172-182, 2011.07.
56. Kato TA, Tateno M, Shinfuku N, Fujisawa D, Teo AR, Sartorius N, Akiyama T, Ishida T, Choi TY, Balhara YPS, Matsumoto R, Umene-Nakano W, Fujimura Y, Wand A, Chang JPC, Chang RYF, Shadloo B, Ahmed HU, Lerthattasilp T, Kanba S, Does the 'hikikomori' syndrome of social withdrawal exist outside Japan?: A preliminary international investigation., Social Psychiatry and Psychiatric Epidemiology, 2011.06.
57. Kato TA, Monji A, Mizoguchi Y, Hashioka S, Horikawa H, Seki Y, Kasai M, Utsumi H, Kanba S, Anti-inflammatory properties of antipsychotics via microglia modulations; Are antipsychotics a 'fire extinguisher' in the brain of schizophrenia?, Mini-Reviews in Medicinal Chemistry, 11.0, 7.0, 565-574, 2011.06.
58. Kato TA, Tateno M, Nakano Y, Balhara YPS, Teo AR, Fujisawa D, Sasaki R, Ishida T, Kanba S, Impact of biopsychosocial factors on psychiatric training in Japan and overseas: Are psychiatrists oriented to mind, brain, or sociocultural issues?, Psychiatry and Clinical Neurosciences, 64.0, 5.0, 520–530, 2010.10.
59. Kato TA, Suzuki Y, Sato R, Fujisawa D, Uehara K, Hashimoto N, Sawayama Y, Hayashi J, Kanba S, Otsuka K, Development of two-hour suicide intervention program among medical residents: First pilot trial., Psychiatry and Clinical Neurosciences, 64.0, 5.0, 531–540, 2010.10.
60. Horikawa H, Kato TA, Mizoguchi Y, Monji A, Seki Y, Gotoh L, Ohkuri T, Yonaha M, Ueda T, Hashioka S, Kanba S, Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracelluar calcium., Prog Neuropsychopharmacol Biol Psychiatry, 37.0, 12.0, 1306–1316, 2010.10.
61. Mizoguchi Y, Monji A, Kato T, Seki Y, Gotoh L, Horikawa H, Suzuki SO, Iwaki T, Yonaha M, Hashioka S, Kanba S, Brain-derived neurotrophic factor (BDNF) induces sustained elevation of intracellular Ca2+ in rodent microglia., Journal of Immunology, 183.0, 12.0, 7778-7786, 2009.12.
62. Monji A, Kato T, Kanba S, Cytokines and Schizophrenia-Microglia Hypothesis of Schizophrenia-., Psychiatry and Clinical Neurosciences, 63.0, 3.0, 257-265, 2009.06.
63. Kato T, Mizoguchi Y, Monji A, Horikawa H, Suzuki S, Seki Y, Iwaki T, Hashioka S, Kanba S, Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro., Journal of Neurochemistry, 106.0, 2.0, 815-825, 2008.07.
64. Bian Q, Kato T, Monji A, Hashioka S, Mizoguchi Y, Horikawa H, Kanba S, The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon- gamma., Prog Neuropsychopharmacol Biol Psychiatry, 32.0, 1.0, 42-48, 2008.01.
65. Kato T, Monji A, Hashioka S, Kanba S, Risperidone significantly inhibits interferon- gamma -induced microglial activation in vitro., Schizophrenia Research, 92.0, 1ー3, 108-115, 2007.05.
66. Kato T, Hanada T, Takano K, Antoku Y, and Nose Y, A Question and Answer E-Mail System for Responding to Query from the General Public with Which the System Manager Can Identify Delayed Replies., J Med Syst, 24.0, 1.0, 21-28, 2000.02.
67. Seki Y, Kato TA*, Monji A*, Mizoguchi Y, Horikawa H, Sato-Kasai M, Yoshiga D, Kanba S, Aripiprazole and minocycline, but not haloperidol, suppress oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model, Schizophrenia Research, 151, 1-3, 20-28.
68. Isomura S, Monji A, Sasaki K, Baba S, Onitsuka T, Ohara T, Mizoguchi Y, Kato TA, Horikawa H, Seki Y, Kanba S:, A case of FTD with catatonia-like signs that temporarily resolved with zolpidem, Neurology: Clinical Practice, 3, 354-357.
69. Watabe M*, Kato TA*, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsumi H, Kanba S [*Double Corresponding authors who were equally contributed to this work.]: , Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange, Scientific Reports, 10.1038/srep01685., 3, 1685.
70. Umene-Nakano W*, Kato TA, Kikuchi S, Tateno M, Fujisawa D, Nationwide Survey of Work Environment, Work-Life Balance and Burnout among Psychiatrists in Japan, PLoS ONE, 10.1371/journal.pone.0055189., 8, 2, e55189.
71. Kato TA*, Yamauchi Y, Horikawa H, Monji A, Mizoguchi Y, Seki Y, Hayakawa K, Utsumi H, Kanba S, Neurotransmitters, Psychotropic Drugs and Microglia: Clinical Implications for Psychiatry, Current Medicinal Chemistry, 20, 3, 331-344.
72. Kato TA, Introducing Hikikomori from multidimensional perspectives. Interview, World Child & Adolescent Psychiatry (WPA, Child and Adolescent Psychiatry Section's Official Journal), 7, 12-16.
73. Kano S-I, Yuan M, Cardarelli RA, Maegawa G, Higurashi N, Gaval-Cruz M, Wilson AM, Tristan C, Kondo MA, Chen Y, Koga M, Obie C, Ishizuka K, Seshadri S, Srivastava R, Kato TA, Horiuchi Y, Sedlak TW, Lee Y, Rapoport JL, Hirose S, Okano H, Valle D, O'Donnell P*, Sawa A*, Kai M*, Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy, Current Molecular Medicine, 15, 2, 138-45.
74. Tateno M, Teo AR, Shirasaka T, Tayama M, Watabe M, Kato TA, Internet addiction and self-evaluated ADHD traits among Japanese college students, Psychiatry and Clinical Neurosciences.
主要総説, 論評, 解説, 書評, 報告書等
主要学会発表等
学会活動
学会誌・雑誌・著書の編集への参加状況
2014.07~2020.10, Neurology, Psychiatry and Brain Research, 国際, 編集委員.
2013.10~2015.10, Frontiers in Cellular Neuroscience, Guest Editor, 国際, 編集委員.
2013.04~2017.12, Frontiers in Psychiatry (Frontiers in Neuropsychiatric Imaging and Stimulation), Associate Editor, 国際, 編集委員.
2007.07~2010.12, Acta Psychiatrica Scandinavica, 国際, Trainee Advisory Board.
学術論文等の審査
年度 外国語雑誌査読論文数 日本語雑誌査読論文数 国際会議録査読論文数 国内会議録査読論文数 合計
2012年度 14      40  54 
2011年度 15        15 
2010年度 13        13 
2009年度      
2008年度      
2007年度      
その他の研究活動
海外渡航状況, 海外での教育研究歴
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, UnitedStatesofAmerica, 2011.08~2012.03.
受賞
若手研究者育成プログラム奨励賞, 日本生物学的精神医学会, 2014.10.
優秀賞, 第9回ドパミン・パーシャル・アゴニスト(DPA)研究会, 2013.02.
第21回(平成24年度)国際研究助成賞, 公益財団法人ファイザーヘルスリサーチ振興財団, 2012.11.
2012年度 医学系研究奨励賞, 公益財団法人 武田科学振興財団, 2012.11.
平成24年度 精神医療奨励賞(MHFA-Jチーム), 日本精神神経学会, 2012.05.
平成23年度 若手派遣助成賞(シンポジウム組織部門:世界精神医学会2010(北京大会)), 日本精神神経学会, 2011.10.
Young Scientists Award, World Federation of Societies of Biological Psychiatry, 2009.06.
Schizophrenia Research First Award, Pacific Rim College of Psychiatry, 2008.11.
平成20年度精神医学奨励賞, 日本精神神経学会, 2008.05.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2018年度~2021年度, 基盤研究(A), 代表, 患者由来直接誘導ニューロン・グリア細胞による精神神経疾患の病態解明:橋渡し研究.
2016年度~2020年度, 新学術領域研究, 代表, 神経グリア発達によるモチベーションの形成とその破綻・修復機構の解明.
2015年度~2017年度, 挑戦的萌芽研究, 代表, 「現代抑うつ症候群(新型うつ・現代型うつ)」の多軸的な診断評価法の開発.
2014年度~2017年度, 若手研究(A), 代表, 精神疾患における神経グリア相関異常を解明するための再生医学技術を用いた橋渡し研究.
2008年度~2009年度, 特別研究員奨励費, 代表, 抗精神病薬のミクログリアを介した神経炎症調整機序の解明から統合失調症の病態を探る.
2010年度~2011年度, 研究活動スタート支援, 代表, 脳内酸化ストレス反応を介した統合失調症の病態機序の解明.
2012年度~2014年度, 挑戦的萌芽研究, 代表, 脳内免疫細胞ミクログリアを介した人間の社会的意志決定プロセスの解明.
日本学術振興会への採択状況(科学研究費補助金以外)
2015年度~2016年度, 二国間交流, 代表, 「社会的ひきこもり」及び「現代抑うつ症候群(新型うつ)」の国際評価法の開発.
2009年度~2009年度, 二国間交流, 連携, アジアの「うつ」「自殺」に対する新しい挑戦: 多文化的多軸的国際共同研究に向けて.
2011年度~2011年度, 平成23年度日米科学技術協力事業「脳研究」分野 共同研究者派遣事業, 代表, 統合失調症における神経細胞とグリア細胞のクロストーク (分野 疾患の神経生物学).
競争的資金(受託研究を含む)の採択状況
2017年度~2019年度, 平成29年度国立研究開発法人日本医療研究開発機構(AMED)障害者対策総合研究開発事業, 代表, 社会的ひきこもりの長期化打開のためのエビデンスに基づく家族向け教育支援モデルの構築.
2014年度~2014年度, 平成26年度研究活動助成(公財)メンタルヘルス岡本記念財団, 代表, 「学術交流・文化交流・相互理解を促進するための「日韓両国の若手精神科医のための合同研修会」」.
2014年度~2016年度, 厚生労働科学研究費補助金 (厚生労働省), 代表, 精神疾患患者早期介入のための医療従事者向け教育研修プログラムの開発ーメンタルヘルス・ファーストエイドの応用ー.
2012年度~2013年度, 第9回ドパミン・パーシャル・アゴニスト(DPA)研究会ー研究助成, 代表, 統合失調症モデル動物におけるオリゴデンドロサイト傷害抑制を介したアリピプラゾールの効果.
2013年度~2014年度, 平成25年度第7回精神薬療分野若手研究者助成, 代表, うつ病特異的な社会的意志決定機序と脳内ミクログリア活動の相関解明―神経経済学研究―.
2008年度~2008年度, 財団法人 先進医薬研究振興財団 平成20年度 第2回精神薬療分野萌芽研究助成, 代表, 抗精神病薬の神経炎症調整機序の解明から統合失調症の病態および治療メカニズムを探る.
2009年度~2010年度, 財団法人 精神・神経科学振興財団 平成21年度 調査研究助成, 代表, 精神科研修および育成される精神科医像に関する国際共同調査ー国・時代・社会に則した精神科医の育成を目指してー.
2010年度~2011年度, World Psychiatric Association (WPA) Research Fund, 代表, How do Sociocultural Environments Influence Toward Recent Psychiatric Syndromes Among Young Generations in Asia?.
2012年度~2013年度, 統合失調症研究会第8回研究助成, 代表, 統合失調症患者の社会的意志決定におけるミノサイクリンの影響.
2012年度~2013年度, 第21回平成24年度公益財団法人ファイザーヘルスリサーチ振興財団・国際研究助成, 代表, 国際調査票開発に基づく現代うつ病と社会的ひきこもりの実態調査.
2012年度~2013年度, 公益財団法人 武田科学振興財団 [2012年度 医学系研究奨励], 代表, 精神疾患患者由来iN神経を用いた神経-グリア相互作用の解明.
学内資金・基金等への採択状況
2010年度~2016年度, 九州大学先端融合医療レドックスナビ研究拠点 若手育成事業, 代表, 脳内酸化ストレス反応を介した統合失調症の病態・治療機序の解明.

九大関連コンテンツ

pure2017年10月2日から、「九州大学研究者情報」を補完するデータベースとして、Elsevier社の「Pure」による研究業績の公開を開始しました。
 
 
九州大学知的財産本部「九州大学Seeds集」