YUMIMOTO KANAE
Organization
Faculty of Sciences Department of Chemistry Associate Professor
School of Sciences Department of Biology（Joint Appointment）
Title
Associate Professor
Contact information
Tel
0928024160
External link
ORCID
Degree
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Ph.D
Awards
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第32回 井上研究奨励賞
2016.2
Papers
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Identification of effective CCR2 inhibitors for cancer therapy using humanized mice. Reviewed International journal
Shigeaki Sugiyama, Kanae Yumimoto, Shun Fujinuma, Keiichi I Nakayama
Journal of biochemistry 2023.11
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A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection Reviewed
Shintaro Funasaki, Atsushi Hatano, Hirokazu Nakatsumi, Daisuke Koga, Osamu Sugahara, Kanae Yumimoto, Masaya Baba, Masaki Matsumoto, Keiichi I. Nakayama
iScience 26 ( 9 ) 107552 - 107552 2023.9
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Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life. Reviewed International journal
Kanae Yumimoto, Shigeaki Sugiyama, Saori Motomura, Daisuke Takahashi, Keiichi I Nakayama
Science advances 9 ( 20 ) eadg2379 2023.5
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F-Box Proteins and Cancer. Reviewed International journal
Kanae Yumimoto, Yuhei Yamauchi, Keiichi I Nakayama
Cancers 12 ( 5 ) 2020.5
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Recent insight into the role of FBXW7 as a tumor suppressor. Reviewed International journal
Kanae Yumimoto, Keiichi I Nakayama
Seminars in cancer biology 2020.2
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Potentials of C-C motif chemokine 2-C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents. Reviewed International journal
Kanae Yumimoto, Shigeaki Sugiyama, Koshi Mimori, Keiichi I Nakayama
Cancer science 110 ( 7 ) 2090 - 2099 2019.7
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SCFFbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation. Reviewed International journal
Shigeaki Sugiyama, Kanae Yumimoto, Ippei Inoue, Keiichi I Nakayama
Genes to cells : devoted to molecular & cellular mechanisms 24 ( 5 ) 354 - 365 2019.5
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Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3. Reviewed International journal
Shogo Nakayama, Kanae Yumimoto, Atsuki Kawamura, Keiichi I Nakayama
The Journal of biological chemistry 293 ( 15 ) 5705 - 5714 2018.4
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FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Reviewed International journal
Masaaki Nishiyama, Akihiro Nita, Kanae Yumimoto, Keiichi I Nakayama
Stem cells (Dayton, Ohio) 33 ( 11 ) 3327 - 40 2015.11
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FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1. Reviewed International journal
Koki Watanabe, Kanae Yumimoto, Keiichi I Nakayama
Genes to cells : devoted to molecular & cellular mechanisms 20 ( 8 ) 667 - 74 2015.8
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Fbxw7 suppresses cancer metastasis by inhibiting niche formation. Reviewed International journal
Kanae Yumimoto, Keiichi I Nakayama
Oncoimmunology 4 ( 8 ) e1022308 2015.8
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Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2. Reviewed International journal
Tomomi Nakajima, Kyoko Kitagawa, Tatsuya Ohhata, Satoshi Sakai, Chiharu Uchida, Kiyoshi Shibata, Naoko Minegishi, Kanae Yumimoto, Keiichi I Nakayama, Kazuma Masumoto, Fuminori Katou, Hiroyuki Niida, Masatoshi Kitagawa
The Journal of biological chemistry 290 ( 16 ) 10368 - 81 2015.4
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F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner. Reviewed International journal
Kanae Yumimoto, Sayuri Akiyoshi, Hiroki Ueo, Yasuaki Sagara, Ichiro Onoyama, Hiroaki Ueo, Shinji Ohno, Masaki Mori, Koshi Mimori, Keiichi I Nakayama
The Journal of clinical investigation 125 ( 2 ) 621 - 35 2015.2
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MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. Reviewed International journal
Takayoshi Yamauchi, Masaaki Nishiyama, Toshiro Moroishi, Kanae Yumimoto, Keiichi I Nakayama
Molecular and cellular biology 34 ( 17 ) 3321 - 40 2014.9
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Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. Reviewed International journal
Kanae Yumimoto, Tetsuya Muneoka, Tomohiro Tsuboi, Keiichi I Nakayama
The Journal of biological chemistry 288 ( 45 ) 32766 - 76 2013.11
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F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. Reviewed International journal
Kanae Yumimoto, Masaki Matsumoto, Ichiro Onoyama, Kazunori Imaizumi, Keiichi I Nakayama
The Journal of biological chemistry 288 ( 40 ) 28488 - 502 2013.10
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FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Reviewed International journal
Arisa Hirano, Kanae Yumimoto, Ryosuke Tsunematsu, Masaki Matsumoto, Masaaki Oyama, Hiroko Kozuka-Hata, Tomoki Nakagawa, Darin Lanjakornsiripan, Keiichi I Nakayama, Yoshitaka Fukada
Cell 152 ( 5 ) 1106 - 18 2013.2
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Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation. Reviewed International journal
Yasutaka Okita, Akinobu Matsumoto, Kanae Yumimoto, Rieko Isoshita, Keiichi I Nakayama
Genes to cells : devoted to molecular & cellular mechanisms 17 ( 9 ) 768 - 77 2012.9
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Comprehensive identification of substrates for F-box proteins by differential proteomics analysis. Reviewed International journal
Kanae Yumimoto, Masaki Matsumoto, Koji Oyamada, Toshiro Moroishi, Keiichi I Nakayama
Journal of proteome research 11 ( 6 ) 3175 - 85 2012.6
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Identification of two isoforms of Dsk2-related protein XDRP1 in Xenopus eggs Reviewed
Kanae Tanaka, Minoru Funakoshi, Kazue Inoue, Hideki Kobayashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 350 ( 3 ) 768 - 773 2006.11
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A Cdc2-sensitive interaction of the UbL domain of XDRP1S with cyclin B mediates the degradation of cyclin B in Xenopus egg extracts Reviewed
Kanae Tanaka, Minoru Funakoshi, Hideki Kobayashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 350 ( 3 ) 774 - 782 2006.11
MISC
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Keap1の分子進化は脊椎動物の地上生活への適応に必須だった：陸上の高活性酸素に対する適応機構の解明
弓本佳苗, 中山敬一
実験医学 2023.10
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【動き始めたがんゲノム医療 深化と普及のための基礎研究課題】(第2章)actionableパスウェイ ユビキチン・プロテアソーム系(UPS)とがん治療戦略
弓本 佳苗, 中山 敬一
実験医学 2018.9
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【がん転移学(上)-がん転移のメカニズムと治療戦略:その基礎と臨床-】がん転移学の基礎研究 がんの浸潤と転移のメカニズム
杉山 成明, 弓本 佳苗, 中山 敬一
日本臨床 2017.11
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がん抑制因子のがんニッチ細胞における機能
弓本 佳苗, 中山 敬一
がん分子標的治療 2016.4
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ユビキチンリガーゼFbxw7はがんニッチ形成を抑制する
弓本佳苗、中山敬一
2015.8
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拡大するF-boxタンパク質の世界
弓本佳苗、中山敬一
2010.12
Professional Memberships
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THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
Research Projects
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ユビキチンリガーゼの組み合わせによる新たな標的拡張メカニズム
Grant number：24K09382 2024 - 2026
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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ヘテロユビキチンリガーゼがもたらすユビキチン化基質認識機構の新展開
Grant number：24H01902 2024 - 2025
日本学術振興会・文部科学省 科学研究費助成事業 学術変革領域研究(A)
Authorship：Principal investigator Grant type：Scientific research funding
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播種性腫瘍細胞を標的とした革新的ながん治療法の開発
2021 - 2024
戦略的創造研究推進事業 (文部科学省)
Grant type：Contract research
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抗腫瘍獲得免疫・NK細胞非依存の新規がん転移抑制ニッチの解明および治療応用
Grant number：20K07592 2020 - 2022
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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乳がん細胞における免疫チェックポイント回避機構の分子基盤の解明
2019 - 2022
日本学術振興会 特別研究員
Authorship：Principal investigator Grant type：Joint research
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がん細胞依存性炎症が全身に及ぼす影響の統合的解明
Grant number：18H05037 2018 - 2019
日本学術振興会・文部科学省 科学研究費助成事業 新学術領域研究（研究領域提案型）
Authorship：Principal investigator Grant type：Scientific research funding
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内藤記念女性研究者研究助成金
2018
Grant type：Donation
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免疫チェックポイント阻害時に働く第二のがん免疫回避機構の同定
Grant number：17K07171 2017 - 2019
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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リン酸化プロテオミクスによるネオセルフを決定する胸腺T細胞シグナル伝達機構の解明
Grant number：17H05795 2017 - 2018
日本学術振興会・文部科学省 科学研究費助成事業 新学術領域研究（研究領域提案型）
Authorship：Principal investigator Grant type：Scientific research funding
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ユビキチン化酵素Fbxw7が癌ニッチで果たす転移抑制メカニズムの解明
Grant number：15H05575 2015 - 2016
科学研究費助成事業 若手研究(A)
Authorship：Principal investigator Grant type：Scientific research funding
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ユビキチン酵素標的を網羅的に探索する革新的技術基盤の確立
Grant number：15H01186 2015 - 2016
日本学術振興会・文部科学省 科学研究費助成事業 新学術領域研究（研究領域提案型）
Authorship：Principal investigator Grant type：Scientific research funding
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ユビキチンリガーゼ疾患の発症機構の解明
Grant number：25860241 2013 - 2015
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
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F-boxタンパク質-基質関係の網羅的探索方法の確立、およびその生理的機能解析
2008 - 2009
日本学術振興会 特別研究員
Authorship：Principal investigator Grant type：Joint research
Class subject
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生物化学IV
2024.10 - 2025.3 Second semester
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身の回りの化学
2024.6 - 2024.8 Summer quarter
Media Coverage
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3億年前、動物はこうして陸上に進出した！ Newspaper, magazine
月刊ジュニアエラ8月号 2023.7
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Response to reactive oxygen species the key to transition of organisms to a terrestrial environment — Kyushu University unravels a mystery of evolution
2023.6
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なぜ生物は水中から陸に進出し生活？「進化の謎」解くたんぱく質を特定…九大チーム
読売新聞オンライン 2023.5
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生物の陸上進出 活性酸素対応がカギ Newspaper, magazine
科学新聞 2023.5
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がん転移抑える薬剤 九大、マウスで確認 Newspaper, magazine
日本経済新聞 朝刊 2015.1
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既存薬でがん転移抑制 Newspaper, magazine
毎日新聞 朝刊 2015.1
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B型肝炎治療薬 がん転移抑える可能性 Newspaper, magazine
朝日新聞 朝刊 2015.1