Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts Reviewed

Tatsuro Takahashi, Abhijit Basu, Vladimir Bermudez, Jerard Hurwitz, Johannes C. Walter

Genes and Development   22 ( 14 )   1894 - 1905   2008.7

Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication Reviewed

Tatsuro Takahashi, Johannes C. Walter

Genes and Development   19 ( 19 )   2295 - 2300   2005.10

Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex Reviewed

Tatsuro Takahashi, Pannyun Yiu, Michael F. Chou, Steven Gygi, Johannes C. Walter

Nature Cell Biology   6 ( 10 )   991 - 996   2004.10

The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5 Reviewed

Ryota Miyashita, Atsuya Nishiyama, Weihua Qin, Yoshie Chiba, Satomi Kori, Norie Kato, Chieko Konishi, Soichiro Kumamoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoshitaka Kawasoe, Toshiki Tsurimoto, Tatsuro S Takahashi, Heinrich Leonhardt, Kyohei Arita, Makoto Nakanishi

eLife   12   e79013   2023.2

Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide Reviewed International journal

Robert P Fuchs, Asako Isogawa, Joao A Paulo, Kazumitsu Onizuka, Tatsuro Takahashi, Ravindra Amunugama, Julien P Duxin, Shingo Fujii

eLife   10   2021.7

Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. International journal

Mathew J K Jones, Camille Gelot, Stephanie Munk, Amnon Koren, Yoshitaka Kawasoe, Kelly A George, Ruth E Santos, Jesper V Olsen, Steven A McCarroll, Mark G Frattini, Tatsuro S Takahashi, Prasad V Jallepalli

Molecular cell   81 ( 3 )   426 - 441   2021.2

Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription Reviewed International journal

Akiko K Okita, Faria Zafar, Jie Su, Dayalini Weerasekara, Takuya Kajitani, Tatsuro S Takahashi, Hiroshi Kimura, Yota Murakami, Hisao Masukata, Takuro Nakagawa

Communications biology   2   17   2019.1

Shelterin promotes tethering of late replication origins to telomeres for replication-timing control Reviewed

Shiho Ogawa, Sayuri Kido, Tetsuya Handa, Hidesato Ogawa, Haruhiko Asakawa, Tatsuro Takahashi, Takuro Nakagawa, Yasushi Hiraoka, Hisao Masukata

EMBO Journal   37 ( 15 )   2018.8

Direct binding of Cdt2 to PCNA is important for targeting the CRL4^Cdt2 E3 ligase activity to Cdt1 Reviewed

Akiyo Hayashi, Nickolaos Nikiforos Giakoumakis, Tatjana Heidebrecht, Takashi Ishii, Andreas Panagopoulos, Christophe Caillat, Michiyo Takahara, Richard G. Hibbert, Naohiro Suenaga, Magda Stadnik-Spiewak, Tatsuro Takahashi, Yasushi Shiomi, Stavros Taraviras, Eleonore Von Castelmur, Zoi Lygerou, Anastassis Perrakis, Hideo Nishitani

Life Science Alliance   1 ( 6 )   2018.1

Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway Reviewed

Cell Reports   21 ( 5 )   1375 - 1385   2017.10

Regulation of mitotic recombination between DNA repeats in centromeres Reviewed

Faria Zafar, Akiko K. Okita, Atsushi T. Onaka, Jie Su, Yasuhiro Katahira, Jun Ichi Nakayama, Tatsuro Takahashi, Hisao Masukata, Takuro Nakagawa

Nucleic Acids Research   45 ( 19 )   11222 - 11235   2017.1

PCNA Retention on DNA into G2/M Phase Causes Genome Instability in Cells Lacking Elg1 Reviewed

Catherine Johnson, Vamsi K. Gali, Tatsuro Takahashi, Takashi Kubota

Cell Reports   16 ( 3 )   684 - 695   2016.7

Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation Reviewed

Atsushi T. Onaka, Naoko Toyofuku, Takahiro Inoue, Akiko K. Okita, Minami Sagawa, Jie Su, Takeshi Shitanda, Rei Matsuyama, Faria Zafar, Tatsuro Takahashi, Hisao Masukata, Takuro Nakagawa

Nucleic Acids Research   44 ( 22 )   10744 - 10757   2016.1

RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in xenopus egg extracts Reviewed

Yosuke Sanuki, Yumiko Kubota, Masato T. Kanemaki, Tatsuro Takahashi, Satoru Mimura, Haruhiko Takisawa

Cell Cycle   14 ( 7 )   1010 - 1023   2015.4

Reconstitution of mitotic chromatids with a minimum set of purified factors Reviewed

Keishi Shintomi, Tatsuro Takahashi, Tatsuya Hirano

Nature Cell Biology   17 ( 8 )   1014 - 1023   2015.1

Thymine DNA glycosylase is a CRL4^Cdt2 substrate Reviewed

Tamara J. Slenn, Benjamin Morris, Courtney G. Havens, Robert M. Freeman, Tatsuro Takahashi, Johannes C. Walter

Journal of Biological Chemistry   289 ( 33 )   23043 - 23055   2014.8

MutS stimulates the endonuclease activity of MutL in an ATP-hydrolysis-dependent manner Reviewed

Atsuhiro Shimada, Yoshitaka Kawasoe, Yoshito Hata, Tatsuro Takahashi, Ryoji Masui, Seiki Kuramitsu, Kenji Fukui

FEBS Journal   280 ( 14 )   3467 - 3479   2013.7

Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast Reviewed

Atsutoshi Tazumi, Masayoshi Fukuura, Ryuichiro Nakato, Ami Kishimoto, Tomokazu Takenaka, Shiho Ogawa, Ji Hoon Song, Tatsuro Takahashi, Takuro Nakagawa, Katsuhiko Shirahige, Hisao Masukata

Genes and Development   26 ( 18 )   2050 - 2062   2012.9

DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast. Reviewed

Tetsuya Handa, Mai Kanke, Tatsuro Takahashi, Takuro Nakagawa, Hisao Masukata

Molecular Biology of the Cell   23 ( 16 )   3240 - 3253   2012.8

In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex Reviewed

Vladimir P. Bermudez, Andrea Farina, Torahiko L. Higashi, Fang Du, Inger Tappin, Tatsuro Takahashi, Jerard Hurwitz

Proceedings of the National Academy of Sciences of the United States of America   109 ( 24 )   9366 - 9371   2012.6

Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components Reviewed

Mai Kanke, Yukako Kodama, Tatsuro Takahashi, Takuro Nakagawa, Hisao Masukata

EMBO Journal   31 ( 9 )   2182 - 2194   2012.5

Abundance of prereplicative complexes (Pre-RCs) facilitates recombinational repair under replication stress in fission yeast Reviewed

Kentaro Maki, Takahiro Inoue, Atsushi Onaka, Hiroko Hashizume, Naoko Somete, Yuko Kobayashi, Shigefumi Murakami, Chikako Shigaki, Tatsuro Takahashi, Hisao Masukata, Takuro Nakagawa

Journal of Biological Chemistry   286 ( 48 )   41701 - 41710   2011.12

CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast Reviewed

Masayoshi Fukuura, Koji Nagao, Chikashi Obuse, Tatsuro Takahashi, Takuro Nakagawa, Hisao Masukata

Molecular Biology of the Cell   22 ( 14 )   2620 - 2633   2011.7

Auxin-inducible protein depletion system in fission yeast Reviewed

Mai Kanke, Kohei Nishimura, Masato Kanemaki, Tatsuo Kakimoto, Tatsuro Takahashi, Takuro Nakagawa, Hisao Masukata

BMC Cell Biology   12   2011.2

DNA replication in nucleus-free xenopus egg extracts

Ronald Lebofsky, Tatsuro Takahashi, Johannes C. Walter

DNA Replication Methods and Protocols   521   229 - 252   2009.12

The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus Reviewed

Makoto T. Hayashi, Tatsuro Takahashi, Takuro Nakagawa, Jun Ichi Nakayama, Hisao Masukata

Nature Cell Biology   11 ( 3 )   357 - 362   2009.2

Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe Reviewed

Ken Ichi Nakamura, Aya Okamoto, Yuki Katou, Chie Yadani, Takeshi Shitanda, Chitrada Kaweeteerawat, Tatsuro Takahashi, Takehiko Itoh, Katsuhiko Shirahige, Hisao Masukata, Takuro Nakagawa

EMBO Journal   27 ( 22 )   3036 - 3046   2008.11

Erratum Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast (The EMBO Journal (2007) 26 (1327-1339) DOI: 10.1038/sj.emboj.7601585) Reviewed

Makoto Hayashi, Yuki Katou, Takehiko Itoh, Atsutoshi Tazumi, Yoshiki Yamada, Tatsuro Takahashi, Takuro Nakagawa, Katsuhiko Shirahige, Hisao Masukata

EMBO Journal   26 ( 11 )   2821   2007.6

Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast Reviewed

Makoto Hayashi, Yuki Katou, Takehiko Itoh, Mitsutoshi Tazumi, Yoshiki Yamada, Tatsuro Takahashi, Takuro Nakagawa, Katsuhiko Shirahige, Hisao Masukata

EMBO Journal   26 ( 5 )   1327 - 1339   2007.3

Multiple ORC-binding sites are required for efficient MCM loading and origin firing in fission yeast Reviewed

Tatsuro Takahashi, Eri Ohara, Hideo Nishitani, Hisao Masukata

EMBO Journal   22 ( 4 )   964 - 974   2003.2

Interaction of fission yeast ORC with essential adenine/thymine stretches in replication origins Reviewed

Tatsuro Takahashi, Hisao Masukata

Genes to Cells   6 ( 10 )   837 - 849   2001

Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins Reviewed

Yuya Ogawa, Tatsuro Takahashi, Hisao Masukata

Molecular and Cellular Biology   19 ( 10 )   7228 - 7236   1999.1

Initiation-protein complex for eukaryotic DNA replication Reviewed

Tatsuro Takahashi, H. Masukata

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   44 ( 12 Suppl )   1804 - 1812   1999

ミスマッチ修復に伴うクロマチンリモデリング反応の試験管内再構成による解析 Invited

@照井　利輝、#金津　瑛一郎、@高橋　達郎

第93回日本遺伝学会年会  2021.9 

Regulation of the fidelity of homology-directed repair in Xenopus egg extracts Invited International conference

Tatsuro Takahashi, Yoshitaka Kawasoe, Satomi Oda, Aya Sakazume

The 11th quinquennial conference on DNA repair  2022.3 

An interface between strand invasion and DNA synthesis during homology-directed repair

2024.7 

MutSα and Smarcad1 form a mispair-activated nucleosome remodeling complex that catalyzes unidirectional nucleosome sliding International conference

2023.6 

Regulation of the fidelity of homology-directed repair in Xenopus egg extracts Invited

2022.7 

MMRシステムによる相同組換え正確性制御のメカニズム Invited

@高橋　達郎

国立遺伝学研究所・研究集会「染色体安定維持研究会」  2021.8 

A balance between pro- and anti-recombination reactions determines the fidelity of homology-directed repair

2021.1 

The quality control mechanism of homology-directed repair in Xenopus egg extracts Invited

@Tatsuro Takahashi

2020.12 

ミスマッチ修復システムによるクロマチンリモデリングの試験管内再構成による解析 Invited

@高橋達郎

日本遺伝学会第92回大会  2020.9 

ミスマッチ塩基に依存したヌクレオソームリモデリングの試験管内再構成

第37回染色体ワークショップ・第18回核ダイナミクス研究会  2019.12 

ミスマッチ塩基に依存したクロマチンリモデリングの試験管内再構成

第25回複製・組換え・修復ワークショップ  2019.11 

Reconstitution of a chromatin-remodeling reaction that facilitates post-replicative DNA mismatch repair

@Riki Terui, @Tatsuro Takahashi

2019.12 

The quality control mechanism of homology-directed repair in Xenopus egg extracts Invited International conference

Tatsuro Takahashi

CHROMOSOME DYNAMICS, An international symposium on chromatin and chromosome stability  2019.12 

In vitro reconstitution of a mismatch-induced nucleosome remodeling reaction Invited

2019.9 

真核生物 DNA ミスマッチ修復機構による遺伝情報維持反応の解析

高橋達郎

国立遺伝学研究所・研究集会「染色体安定維持研究会」  2019.6 

ミスマッチ修復による相同組み換え制御の試験管内解析

高橋　達郎

国立遺伝学研究所・研究集会「生物ゲノム安定性の分子機構」  2016.10 

Interplay between DNA synthesis, chromatin assembly, and mismatch repair International conference

Tatsuro Takahashi, Yoshitaka Kawasoe, Riki Terui, koji Nagao, Seiji Tanaka, Takuro Nakagawa, Chikashi Obuse, Hisao Masukata

The 10th 3R symposium  2016.11 

In vitro analysis of interplay between chromatin replication, homology-directed repair, and mismatch repair Invited

Tatsuro Takahashi, Riki Terui, Satomi Oda, Yoshitaka Kawasoe, Takuro Nakagawa, Hisao Masukata

2016.12 

ミスマッチ修復依存的なヘテロ二重鎖解消反応の試験管内解析

第34回染色体ワークショップ・第15回核ダイナミクス研究会  2017.1 

An in vitro model system for functional interaction of mismatch repair with chromatin assembly and homology-directed repair Invited International conference

Tatsuro Takahashi

The 6th US-Japan DNA Repair Meeting  2017.5 

A PCNA-dependent reaction facilitates replication-coupled Sororin loading in Xenopus egg extracts International conference

Torahiko Higashi, Sae Hayashi, Kodai Hara, Hiroshi Hashimoto, Takuro Nakagawa, Hisao Masukata, Tatsuro Takahashi

Cold Spring Harbor Laboratory Meeting "Eukaryotic DNA replication & Genome Maintenance"  2017.9 

PCNAを介したDNA複製と染色体接着の機能的カップリング 

国立遺伝学研究所・研究集会「染色体構築と安定化を担う分子機構」  2017.10 

In vitro analysis of the mismatch-repair-dependent anti-recombination reaction

Satomi Oda, Yoshitaka Kawasoe, Aya Sakazume, Takuro Nakagawa, Hisao Masukata, Tatsuro Takahashi

2017.12 

類似配列間の相同性依存的組換えを抑制する反応の試験管内再現

第35回染色体ワークショップ・第16回核ダイナミクス研究会  2017.12 

相同性依存的修復の品質管理機構を試験管内再現系によって探る Invited

第３回ゲノム編集学会年会  2018.6 

オーガナイザー

第27回DNA複製・組換え・修復ワークショップ  （ 福岡県福岡市 ） 2023.6

Screening of academic papers

Role(s)： Peer review

2023

The Journal of Biochemistry International contribution

2022.1 - 2024.12

Screening of academic papers

Role(s)： Peer review

2022

シンポジウムオーガナイザー

第94回日本生化学会大会  （ 神奈川県横浜市 ） 2021.11

オーガナイザー

第38回染色体ワークショップ・第19回核ダイナミクス研究会  （ オンライン ） 2021.1

Screening of academic papers

Role(s)： Peer review

2021

Screening of academic papers

Role(s)： Peer review

2020

ミーティングオーガナイザー

国立遺伝学研究所・研究集会「染色体安定維持研究会」  （ 静岡県三島市　国立遺伝学研究所 ） 2019.6

Screening of academic papers

Role(s)： Peer review

2019

The Journal of Biochemistry International contribution

Role(s)： Peer review

2018.4 - 2020.3

Screening of academic papers

Role(s)： Peer review

2018

ワークショップオーガナイザー

2017年度生命科学系学会合同年次大会  （ 兵庫県神戸市 ） 2017.12

ミーティングオーガナイザー

国立遺伝学研究所・研究集会「染色体構築と安定化を担う分子機構」  （ 静岡県三島市 ） 2017.10

Screening of academic papers

Role(s)： Peer review

2016

真核生物Mcm8–9ヘリカーゼの機能制御機構の解明

2023.4 - 2024.3

共同研究

塩基ミスマッチを起点とするゲノム複製正確性維持反応と非ゲノム情報の機能的相関

Grant number：22H04697  2022 - 2023

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

豊田理研スカラー

2021

山田科学振興財団研究援助／相同組換えの正確性を保証するメカニズムの理解

2021

豊田理研スカラー　共同研究Phase1

2021

DNA複製と相同性依存的修復の正確性維持機構を統御する反応の解明

Grant number：20H03186  2020 - 2023

日本学術振興会  科学研究費助成事業  基盤研究(B)

損傷チェックポイント機構によるDNA二重鎖切断修復の正確性制御メカニズム

Grant number：20K21399  2020 - 2021

日本学術振興会  科学研究費助成事業  挑戦的研究（萌芽）

ゲノム情報の複製正確性維持機構と非ゲノム情報維持反応のクロストークの解明

Grant number：20H05392  2020 - 2021

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

オーキシンデグロン法を用いた複製クランプPCNAの新規機能の解析

2018.4 - 2019.3

共同研究

相同性依存的修復の品質管理機構を次世代シーケンス技術を用いて探る

Grant number：18H04716  2018 - 2019

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

ミスマッチ修復システムによる相同組換え品質保証機構の動作原理の解明

Grant number：17H01876  2017 - 2019

日本学術振興会  科学研究費助成事業  基盤研究(B)

武田科学振興財団・ライフサイエンス研究助成

2017

上原記念生命科学振興財団・研究助成金

2017

ミスマッチ修復による合成エラー修復と誤った相同組み換え抑制の統一的理解

Grant number：16K14671  2016 - 2018

科学研究費助成事業  挑戦的萌芽研究

持田記念医学薬学振興財団

2016

コヒーシンが染色体接着と二重鎖切断修復に機能する機構の試験管内再構成による解析

Grant number：25711022  2013 - 2016

科学研究費助成事業  若手研究(A,B)

生物科学I

2024.4 - 2024.6   Spring quarter

Basic BiologyⅠ

2024.4 - 2024.6   Spring quarter

細胞生物学

2023.10 - 2024.3   Second semester

先端生命科学

2023.4 - 2023.9   First semester

分子生物学

2023.4 - 2023.9   First semester

生物科学I

2023.4 - 2023.6   Spring quarter

細胞生物学

2022.10 - 2023.3   Second semester

生物科学特論Ⅱ

2022.6 - 2022.8   Summer quarter

Biology, Advanced CouresⅡ

2022.6 - 2022.8   Summer quarter

分子生物学

2022.4 - 2022.9   First semester

先端生命科学

2022.4 - 2022.9   First semester

生物科学Ⅰ

2022.4 - 2022.6   Spring quarter

Basic BiologyⅠ

2022.4 - 2022.6   Spring quarter

細胞生物学

2021.10 - 2022.3   Second semester

分子生物学

2021.4 - 2021.9   First semester

先端生命科学

2021.4 - 2021.9   First semester

生物科学Ⅰ

2021.4 - 2021.6   Spring quarter

Basic BiologyⅠ

2021.4 - 2021.6   Spring quarter

細胞生物学

2020.10 - 2021.3   Second semester

分子生命科学特論Ⅱ

2020.6 - 2020.8   Summer quarter

分子生物学

2020.4 - 2020.9   First semester

先端生命科学

2020.4 - 2020.9   First semester

分子生命科学I

2020.4 - 2020.6   Spring quarter

細胞生物学

2019.10 - 2020.3   Second semester

分子生物学

2019.4 - 2019.9   First semester

先端生命科学

2019.4 - 2019.9   First semester

分子生命科学I

2019.4 - 2019.6   Spring quarter

細胞生物学

2018.10 - 2019.3   Second semester

分子生物学

2018.4 - 2018.9   First semester

先端生命科学

2018.4 - 2018.9   First semester

分子生命科学I

2018.4 - 2018.6   Spring quarter

分子生命科学特論Ⅱ

2018.4 - 2018.6   Spring quarter

細胞生物学

2017.10 - 2018.3   Second semester

分子生物学

2017.4 - 2017.9   First semester

先端生命科学

2017.4 - 2017.9   First semester

分子生命科学Ⅰ

2017.4 - 2017.6   Spring quarter

2019.10   Role：Participation   Title：（生物学科FD）科研費改革後の学術研究動向について

Organizer：Undergraduate school department

2018.5   Role：Participation   Title：生物科学部門ファカルティディベロプメント（FD）講演会

Organizer：Undergraduate school department

2017.9   Role：Participation   Title：生物科学部門ファカルティディベロプメント（FD）講演会

Organizer：Undergraduate school department

2017.5

Staying countory name 1：United States   Staying institution name 1：Stanford University