Updated on 2025/04/18

Information

 

写真a

 
Shibata Kensuke
 
Organization
Faculty of Medical Sciences Associate Professor
Title
Associate Professor
Tel
0926426962

Degree

  • doctor

Research History

  • Taisho pharmaceutical Co. Ltd   

    Taisho pharmaceutical Co. Ltd

Research Interests・Research Keywords

  • Research theme: Examination of mechanism of autoimmune pancreatitis

    Keyword: autoimmune disease

    Research period: 2016.4 - 2018.3

  • Research theme: The role and functional regulation of innate T lymphocytes

    Keyword: T cells, IL-17

    Research period: 2005.4 - 2013.3

Awards

  • 日本生体防御学会奨励賞

    2011.7   日本生体防御学会  

Papers

  • In vivo blockade of T cell development reveals alternative pathways for generation of intraepithelial lymphocytes in mice Reviewed International journal

    Kensuke Shibata, Surenchimeg Mondoon, Yasunobu Yoshikai

    Immunology Letters   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice. Reviewed International journal

    Nakamura Masataka, Kensuke Shibata, Hatano Shinya, 佐藤 哲也, 大川 恭行, 山田 久方, 生田宏一, 吉開 泰信

    Journal of Immunology   194 ( 1 )   243 - 251   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1401619

  • IFN-gamma-Producing and IL-17-Producing gammadelta T Cells Differentiate at Distinct Developmental Stages in Murine Fetal Thymus Reviewed International journal

    Kensuke Shibata, 山田 久方, Masataka Nakamura, Shinya Hatano, Yoshinori Katsuragi, Ryo Kominami, 吉開 泰信

    Journal of immunology   192 ( 5 )   2210 - 2218   2014.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: jimmunol.1302145 [pii] 10.4049/jimmunol.1302145

  • A C-type lectin receptor pathway is responsible for the pathogenesis of acute cyclophosphamide-induced cystitis in mice Reviewed International journal

    Takashi Dejima, Kensuke Shibata, HISAKATA YAMADA, Ario Takeuchi, Hiromitsu Hara, Masatoshi Eto, Seiji Naito, Yasunobu Yoshikai

    MICROBIOLOGY AND IMMUNOLOGY   57 ( 12 )   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1348-0421.12100

  • A protective role of naturally occurring IL-17A-producing {gamma}{delta} T cells in the lung at the early stage of systemic candidiasis in mice Reviewed International journal

    Dejima, T., Shibata, K., Yamada, H., Hara, H., Iwakura, Y., Naito, S., Yoshikai, Y.

    Infection and Immunity   79 ( 11 )   2011.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Notch-Hes1 pathway is required for the development of IL-17-producing {gamma}{delta} T cells. Reviewed International journal

    Shibata K, Yamada H, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, Iwakura Y, Kawamoto H, Toh H, Yoshikai Y.

    Blood   118 ( 3 )   2011.7

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  • Identification of CD25+ γδ T cells as fetal thymus-derived naturally occurring IL-17 producers. Reviewed International journal

    Shibata, K., Yamada, H., Nakamura, R., Sun, X., Itsumi, M., and Yoshikai, Y.

    Journal of Immunology   181 ( 9 )   2008.11

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  • Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol 178, 4466-4472 Reviewed International journal

    Shibata, K., Yamada, H., Hara, H., Kishihara, K., and Yoshikai,

    Journal of Imunology   178 ( 7 )   2007.4

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  • Chemistry Reviewed International journal

    Ko Sato, Omahdi Zakaria, Kensuke Shibata, Koh-Hei Sonoda, Sho Yamasaki, Hiroshi Tanaka

    2017.9

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  • Type I Interferon Plays Opposing Roles in Cytotoxicity and Interferon-gamma Production by Natural Killer and CD8 T Cells after Influenza A Virus Infection in Mice Reviewed International journal

    Yojiro Arimori, Risa Nakamura, 山田 久方, Kensuke Shibata, Naoyoshi Maeda, Tetsuo Kase, 吉開 泰信

    Journal of innate immunity   2014.1

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    DOI: 000356824 [pii] 10.1159/000356824

  • CD30 Is Required for Activation of a Unique Subset of Interleukin-17A-Producing gamma delta T Cells in Innate Immunity against Mycobacterium bovis Bacillus Calmette-Guerin Infection Reviewed International journal

    Ying Guo, Xun Sun, Kensuke Shibata, 山田 久方, Hiromi Muta, Eckhard R Podack, 吉開 泰信

    INFECTION AND IMMUNITY   81 ( 10 )   2013.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/IAI.00887-13

  • Type I interferon limits influenza virus-induced acute lung injury by regulation of excessive inflammation in mice Reviewed International journal

    Yojiro Arimori, Risa Nakamura, 山田 久方, Kensuke Shibata, Naoyoshi Maeda, Tetsuo Kase, 吉開 泰信

    ANTIVIRAL RESEARCH   99 ( 3 )   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.antivira1.2013.05.007

  • Positive selection of self-antigen-specific CD8(+) T cells by hematopoietic cells Reviewed International journal

    HISAKATA YAMADA, Kensuke Shibata, Koji Sakuraba, Kenjiro Fujimura, Yasunobu Yoshikai

    EUROPEAN JOURNAL OF IMMUNOLOGY   43 ( 8 )   2013.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/eji.201242957

  • CD30L/CD30 is critical for maintenance of IL-17A-producing gammadelta T cells bearing Vgamma6 in mucosa-associated tissues in mice. Reviewed International journal

    Sun Xun, Kensuke Shibata, HISAKATA YAMADA, Guo Ying, Muta Hiromi, Podack Eckhard R, Yasunobu Yoshikai

    Mucosal immmunology   2013.4

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  • Naturally occurring PD-1+ memory phenotype CD8 T cells belong to nonconventional CD8 T cells and are cyclophosphamide-sensitive regulatory T cells. Reviewed International journal

    Koji Sakuraba, Kensuke Shibata, Yukihide Iwamoto, Yasunobu Yoshikai, HISAKATA YAMADA

    Journal of Immunology   ( 190 )   1560 - 1566   2013.2

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  • The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice

    Fuchiwaki Takafumi, Sun Xun, Fujimura Kenjiro, HISAKATA YAMADA, Kensuke Shibata, Muta Hiromi, Podack Eckhard R, Kawauchi Hideyuki, Yasunobu Yoshikai

    EUROPEAN JOURNAL OF IMMUNOLOGY   41 ( 10 )   2011.10

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    Language:English  

    DOI: 10.1002/eji.201141423

  • CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice. Reviewed International journal

    Sun X, Yamada H, Shibata K, Muta H, Tani K, Podack ER, Yoshikai Y.

    Journal of Immunology   185 ( 4 )   2011.8

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  • Innate memory phenotype CD4(+) T cells play a role in early protection against infection with Listeria monocytogenes in a CD30L-dependent manner. Reviewed International journal

    Umeda K, Sun X, Guo Y, Yamada H, Shibata K, Yoshikai Y.

    Microbiology and Immunology   2011.6

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  • IL-17 production by gammadelta T cells is important for the antitumor effect of Mycobacterium bovis bacillus Calmette-Guerin treatment against bladder cancer. Reviewed International journal

    Takeuchi A, Dejima T, Yamada H, Shibata K, Nakamura R, Eto M, Nakatani T, Naito S, Yoshikai Y.

    European Journal of Immunology   41   2011.1

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  • CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses. Reviewed International journal

    Sun X, Yamada H, Shibata K, Muta H, Tani K, Podack ER, Iwakura Y, Yoshikai Y.

    Journal of Immunology   185 ( 12 )   2010.12

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  • Interleukin-15 is critical in the pathogenesis of influenza A virus-induced acute lung injury. Reviewed International journal

    Nakamura R, Maeda N, Shibata K, Yamada H, Kase T, Yoshikai Y.

    Journal of Virology   84 ( 11 )   2010.6

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  • Oral administration of xanthan gum enhances antitumor activity through Toll-like receptor 4. Reviewed International journal

    Takeuchi A, Kamiryou Y, Yamada H, Eto M, Shibata K, Haruna K, Naito S, Yoshikai Y.

    International Immunopharmacology   9 ( 13-14 )   2009.12

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  • IL-15 protects antigen-specific CD8+ T cell contraction after Mycobacterium bovis bacillus Calmette-Guerin infection. Reviewed International journal

    Tang C, Yamada H, Shibata K, Yoshida SI, Wajjwalku W, Yoshikai Y.

    Journal of leukocyte biology   86 ( 1 )   2009.4

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  • A Novel Role of CD30L/CD30 Signaling by T-T Cell Interaction in Th1 Response against Mycobacterial Infection. Reviewed International journal

    Tang, C., Yamada, H., Shibata, K., Muta, H., Wajjwalku, W., Podack, E. R. and Yoshikai, Y.

    Journal of Immunology   181 ( 9 )   2008.11

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  • Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by γδ T cells. Reviewed International journal

    Nakamura, R., Shibata, K., Yamada, H., Shimoda, K., Nakayama, K., and Yoshikai, Y.

    Journal of Immunology   181 ( 3 )   2008.8

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  • Efficacy of recombinant bacille Calmette-Guerin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis. Reviewed International journal

    Tang, C., Yamada, H., Shibata, K., Maeda, N., Yoshida, S., Wajjwalku, W., Ohara, N., Yamada, T., Kinoshita, T., and Yoshikai, Y.

    Journal of Infectious disease   197 ( 9 )   2008.3

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  • A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Reviewed International journal

    Sun X, Somada S, Shibata K, Muta H, Yamada H, Yoshihara H, Honda K, Nakamura K, Takayanagi R, Tani K, Podack ER, Yoshikai Y.

    Gastroenterology   134 ( 2 )   2008.2

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    Language:English   Publishing type:Research paper (scientific journal)  

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Presentations

  • Innate-like T cells for health and disease Invited International conference

    Kensuke Shibata

    International conference of Korean Society for Biochemistry and Molecular Biology  2017.5 

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    Event date: 2017.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:Busan   Country:Korea, Republic of  

  • 自己免疫疾患発症に関わるabT細胞サブセットの同定と機能解析

    Kensuke Shibata, Surenchimeg Mondoon, 石川 絵里, 塩川萌, 山﨑 晶, 吉開 泰信

    京都T cell conference  2016.5 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:滋賀   Country:Japan  

  • Helper T cell-independent development of fatal autoimmune pancreatitis Invited

    Kensuke Shibata, Surenchimeg Mondoon, 山﨑 晶, 吉開 泰信

    日本免疫学会  2015.11 

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    Event date: 2015.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:札幌   Country:Japan  

  • IFN-γ-producing and IL-17-producing γδ T cells differentiate at distinct developmental stages in murine fetal thymus.

    Shinya Hatano, Kensuke Shibata, HISAKATA YAMADA, Yasunobu Yoshikai

    日本免疫学会  2014.12 

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    Event date: 2014.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • T細胞分化と生体防御 Invited

    Kensuke Shibata, 吉開 泰信

    日本生体防御学会  2014.7 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東北大学   Country:Japan  

  • IFN-γ-producing and IL-17-producing γδ T cells differentiate at distinct developmental stages in murine fetal thymus. International conference

    Kensuke Shibata, HISAKATA YAMADA, Masataka Nakamura, Shinya Hatano, Yoshinori Katsuragi, Ryo Kominami, Yasunobu Yoshikai

    gamma delta T cell conference  2014.5 

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    Event date: 2014.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:Chicago   Country:United States  

    γδ T cells develop at the double-negative (DN) 2 and DN3 stages and acquire functions to produce IL-17 and IFN-γ in fetal thymus. However, the relationship between differentiation stages and their functions was unclear. In this work, we found that, although IFN-γ-producing and IL-17-producing γδ T cells developed from DN2 cells, only IFN-γ-producing γδ T cells developed from DN3 cells, indicating the direct generation of IL-17-producing γδ T cells from the DN2 stage not through the DN3 stage. Single-cell analysis revealed that DN2 cells contained heterogeneous γδ T cell precursors with or without an ability to develop IL-17 producers. Inactivation of B-cell leukemia/lymphoma 11B (Bcl11b), a zinc finger transcription factor responsible for transition from early to late stages of DN2 cells, completely abrogated the development of IL-17-producing γδ T cells, though a unique subset of IFN-γ-producing γδ T cells expressing a high level of promyelocytic leukemia zinc finger (PLZF) was able to develop. Thus, our results reveal that γδ T cells are functionally differentiated to IFN-γ and IL-17 producers at different developmental stages in fetal thymus.

  • IL-17-producing γδ T cells develop directly from double-negative 2 cells in murine fetal thymus in Bcl11b-dependent manner

    Kensuke Shibata, HISAKATA YAMADA, Masataka Nakamura, Yasunobu Yoshikai

    日本免疫学会  2013.12 

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    Event date: 2013.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • Notch-RBP-Jκ-IL-7 receptor alpha axis is essential for the maintenance of IL-17-producing γδ T cells

    Kensuke Shibata, Masataka Nakamura, Hisakata Yamada, Koichi Ikuta and Yasunobu Yoshikai

    日本免疫学会  2012.12 

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    Event date: 2012.12

    Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • Notch-IL-7Rα経路は自然発生IL-17産生γδ T細胞の維持に必須である

    中村真隆、柴田健輔、山田久方、吉開泰信

    日本生体防御学会  2012.7 

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    Event date: 2012.7

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Notch、γδTCRシグナルによるγδ T細胞機能分化制御

    柴田健輔、中村真隆、山田久方、吉開泰信

    日本生体防御学会  2012.7 

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    Event date: 2012.7

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • NotchシグナルはIL-17産生γδ T細胞の維持に必須である

    柴田健輔、中村真隆、山田久方、生田宏一、吉開泰信

    京都 T cell conference  2012.7 

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    Event date: 2012.7

    Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • Intrathymic programming of murine gd T cells by Notch signaling International conference

    Kensuke Shibata, Hisakata Yamada, Yasunobu Yoshikai

    gd T cell conference  2012.6 

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    Event date: 2012.5 - 2012.6

    Presentation type:Symposium, workshop panel (public)  

    Venue:Freiburg   Country:Germany  

  • Naturally occurring IL-17-producing γδ T cells commit at the DN2 stage of mouse fetal thymus in Notch-dependent manner

    Shibata Kensuke, Yamada Hisakata, Yoshikai Yasunobu

    日本免疫学会  2011.11 

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    Event date: 2011.11

    Presentation type:Oral presentation (general)  

    Venue:千葉、幕張メッセ   Country:Japan  

  • Notch-Hes1経路は自然発生IL-17産生γδ T細胞分化に必要である

    柴田健輔、山田久方、吉開泰信

    日本生体防御学会  2011.6 

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    Event date: 2011.6 - 2011.7

    Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • 胸腺におけるγδT細胞機能獲得機構の解析

    柴田健輔、山田久方、吉開泰信

    Kyoto T cell conference  2011.6 

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    Event date: 2011.6

    Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • The Basic Helix-Loop-Helix protein HES1 controls the differentiation of naturally occurring interleukin (IL)-17-producing γδ T cells International conference

    Kensuke Shibata, Hisakata Yamada, Tetsuya Sato, Hiromitsu Hara, Sho Yamasaki, Ryoichiro Kageyama, Yasunobu Yoshikai

    14th International Congress Of Immunology  2010.8 

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    Event date: 2010.8

    Presentation type:Oral presentation (general)  

    Venue:神戸ポートピアホテル   Country:Japan  

  • The basic Helix-loop-Helix protein HES1は自然発生IL-17産生gdT細胞分化に必要である。

    柴田健輔、山田久方、吉開泰信

    日本生体防御学会  2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  • The Basic Helix-Loop-Helix protein HES1, is required for the differentiation of naturally occurring interleukin(IL)-17-producing gd T cells. International conference

    Kensuke Shibata, Hisakata Yamada, Tetsuya Sato, Hiromitsu Hara, Sho Yamasaki, Ryoichiro Kageyama, Yoichiro Iwakura, Hiroyuki Toh and Yasunobu Yoshikai

    gd T cell conference  2010.5 

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    Event date: 2010.5

    Presentation type:Symposium, workshop panel (public)  

    Venue:Kiel   Country:Germany  

  • 細菌および真菌に対する生体防御におけるnaturally occurring IL-17産生gd T細胞の役割

    柴田健輔、出嶋卓、山田久方、吉開泰信

    日本細菌学会  2010.3 

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    Event date: 2010.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:パシフィコ横浜   Country:Japan  

  • 胸腺におけるIL-17産生gdT細胞転写制御機構の解析

    SHIBATA Kensuke, YAMADA Hisakata, YOSHIKAI Yasunobu

    日本免疫学会  2009.12 

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    Event date: 2009.12

    Presentation type:Oral presentation (general)  

    Venue:大阪国際会議場   Country:Japan  

  • IL-17産生gd T細胞機能分化に関わる転写制御機構の解析

    柴田健輔

    生体防御学会  2009.7 

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    Event date: 2009.7

    Presentation type:Oral presentation (general)  

    Venue:東京医科歯科大学   Country:Japan  

  • Identification of CD25+ γδ T cells as fetal thymus-derived naturally occurring IL-17 producers. International conference

    Kensuke Shibata

    The 5th International Workshop of Kyoto T Cell Conference  2009.6 

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    Event date: 2009.6

    Presentation type:Oral presentation (general)  

    Venue:京都大学   Country:Japan  

  • CD25陽性IL-17産生γδ T細胞は胎児胸腺で機能分化を果たす

    柴田健輔,山田久方,中村梨沙,孫遜,逸見百江,吉開泰信.

    日本胸腺研究会  2009.2 

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    Event date: 2009.2

    Presentation type:Oral presentation (general)  

    Venue:九州大学   Country:Japan  

  • CD25陽性IL-17産生γδ T細胞は胎児胸腺で機能分化を果たす

    柴田健輔,山田久方,中村梨沙,孫遜,逸見百江,吉開泰信.

    日本免疫学会  2008.12 

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    Event date: 2008.12

    Presentation type:Oral presentation (general)  

    Venue:国立京都国際会館   Country:Japan  

  • CD25陽性IL-17産生γδ T細胞は胎児胸腺で機能分化を果たす

    柴田健輔,山田久方,中村梨沙,孫遜,逸見百江,吉開泰信.

    日本生体防御学会  2008.7 

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    Event date: 2008.7

    Presentation type:Oral presentation (general)  

    Venue:北海道大学   Country:Japan  

  • Impact of the ROCK inhibitor ripasudil on distribution of claudin-5 in vascular endothelial cells in diabetic retinopathy. International conference

    Mitsuru Arima, Shintaro Nakao, @Feng Hao, #Muneo Yamaguchi, Kensuke Shibata, #Yoshihiro Kaizu, #Iori Wada, Shigeo Yoshida, Kohei Sonoda

    The Association for Research in Vision and Ophthalmology  2018.5 

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    Event date: 2018.4 - 2018.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:Honolulu, Hawaii   Country:United States  

  • In vivo blockade of T cell development defines developmental pathways of intraepithelial lymphocytes in mice.

    Surenchimeg Mondoon, Kensuke Shibata, Yasunobu Yoshikai

    日本免疫学会  2016.12 

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    Event date: 2016.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:沖縄   Country:Japan  

  • Scavenger receptor for lipoteichonic acid is involved in the potent ability of Lactobacillus platarum strain L-137 for IL-12p40 production

    Hirose Yoshitaka, Hatano Shinya, Kensuke Shibata, Murosaki Shinji, Yasunobu Yoshikai

    日本免疫学会  2014.12 

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    Event date: 2014.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • Notch-RBP-Jk-IL-7Rα pathway plays a pivotal role in the maintenance of IL-17-producing γδ T cells

    Nakamura Masataka, Kensuke Shibata, HISAKATA YAMADA, Koichi Ikuta, Yasunobu Yoshikai

    日本免疫学会  2013.12 

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    Event date: 2013.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • A novel role of CD30L/CD30 signaling by naturally occurring IL-17A-producing γδ T cells in response against Mycobacterium bovis BCG

    GUO Ying, SUN xun, Kensuke Shibata, HISAKATA YAMADA, PODACK Eckhard R., Yasunobu Yoshikai

    日本免疫学会  2013.12 

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    Event date: 2013.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • The critical role of CD30L/CD30 signaling in the pathogenesis of experimental autoimmune encephalomyelitis

    Shinoda Koji, Sun Xun, Yamada Hisakata, Shibata Kensuke, Kira Junichi, Yoshikai Yasunobu

    日本免疫学会  2012.12 

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    Event date: 2012.12

    Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • The critical role of CD30L in early protection against Listeria monocytogenes in innate gdT cells in mice

    Guo Ying, Sun Xun, Shibata Kensuke, Huang Yinxia, Yamada Hisakata, Muta Hiromi, Eckhard R. Podack, Yoshikai Yasunobu

    日本免疫学会  2011.11 

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    Event date: 2011.11

    Presentation type:Symposium, workshop panel (public)  

    Venue:千葉、幕張メッセ   Country:Japan  

  • The possibility of the treatment targeting Interleukin-15 or CD8 T cells against the pathogenesis of influenza A virus–induced acute lung injury

    Nakamura Risa, Maeda Naoyoshi, Shibata Kensuke, Yamada Hisakata, Ohteki Toshiaki, Yoshikai Yasunobu

    日本免疫学会  2011.11 

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    Event date: 2011.11

    Presentation type:Oral presentation (general)  

    Venue:千葉、幕張メッセ   Country:Japan  

  • Type I interferon limits acute lung injury caused by influenza A H1N1 virus via down-modulation of excessive immune responses in mice

    Arimori Yojiro, Nakamura Risa, Maeda Naoyoshi, Shibata Kensuke, Yamada Hisakata, Kase Tetsuo, Yoshikai Yasunobu

    日本免疫学会  2011.11 

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    Event date: 2011.11

    Presentation type:Oral presentation (general)  

    Venue:千葉、幕張メッセ   Country:Japan  

  • IL-7-receptor-α-mediated signaling is required for the development of naturally occurring IL-17-producing γδ T cells in the adult thymus

    Nakamura Masataka, Shibata Kensuke, Yamada Hisakata, Ikuta Koichi, Yoshikai Yasunobu

    日本免疫学会  2011.11 

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    Event date: 2011.11

    Presentation type:Oral presentation (general)  

    Venue:千葉、幕張メッセ   Country:Japan  

  • A protective role of naturally occurring IL-17A-producing γδT cells in the lung at the early stage of systemic candidiasis in mice

    Dejima Takashi, Shibata Kensuke, Yamada Hisakata, Yoshikai Yasunobu

    日本免疫学会  2011.11 

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    Event date: 2011.11

    Presentation type:Symposium, workshop panel (public)  

    Venue:千葉、幕張メッセ   Country:Japan  

  • The role of Tyk2 in maintenance and activation of naturally occurring IL-17A-producing gd T cells in mice

    Oyamada Akiko, Shibata Kensuke, Yoshikai Yasunobu, Yamada Hisakata

    日本免疫学会  2011.11 

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    Event date: 2011.11

    Presentation type:Symposium, workshop panel (public)  

    Venue:千葉、幕張メッセ   Country:Japan  

  • The critical role of CD30L in maintenance and activation of naturally occurring IL-17A-producing gammadelta T cells in mice

    Sun Xun, Guo Ying, Shibata Kensuke, Huang Yinxia, Yamada Hisakata, Muta Hiromi, Eckhard R. Podack, Yoshikai Yasunobu

    日本免疫学会  2011.11 

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    Event date: 2011.11

    Presentation type:Symposium, workshop panel (public)  

    Venue:千葉、幕張メッセ   Country:Japan  

  • インターロイキン‐15 を標的にしたインフルエンザA ウイルス感染による急性肺障害の治療の開発研究

    中村梨沙、前田直良、柴田健輔、山田久方、加瀬哲男、樗木俊聡、吉開泰信

    日本生体防御学会  2011.6 

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    Event date: 2011.6 - 2011.7

    Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • IL-7による自然発生IL-17産生γδT細胞機能制御機構の解析

    中村真隆、柴田健輔、山田久方、吉開泰信

    日本生体防御学会  2011.6 

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    Event date: 2011.6 - 2011.7

    Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • Candida albicans感染防御における自然発生IL-17A産生γδT細胞の役割

    出嶋卓、柴田健輔、山田久方、吉開泰信

    日本生体防御学会  2011.6 

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    Event date: 2011.6 - 2011.7

    Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • 自然発生IL-17 産生γδT 細胞活性化におけるCD30 Ligand の役割

    孫遜、郭颖、黄銀霞、柴田健輔、山田久方、吉開泰信

    日本生体防御学会  2011.6 

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    Event date: 2011.6 - 2011.7

    Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • 致死性インフルエンザ感染におけるⅠ型インターフェロンの役割

    有森陽二郎、中村梨沙、柴田健輔、山田久方、吉開泰信

    日本生体防御学会  2011.6 

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    Event date: 2011.6 - 2011.7

    Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice International conference

    Xun Sun, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Kenzaburo Tani, Eckhard Podack, Yasunobu Yoshikai

    14th International Congress Of Immunology  2010.8 

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    Event date: 2010.8

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • A protective role of IL-17-producing γδ T cells in lung against systemic candidiasis International conference

    Takashi Dejima, Kensuke Shibata, Hisakata Yamada, Yoshikai Yoshikai

    14th International Congress Of Immunology  2010.8 

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    Event date: 2010.8

    Presentation type:Oral presentation (general)  

    Venue:神戸ポートピアホテル   Country:Japan  

  • Interleukin-15 is critical in the pathogenesis of influenza A virus-induced acute lung injury International conference

    Risa Nakamura, Naoyoshi Maeda, Osamu Noyori, Kensuke Shibata, Hisakata Yamada, Yoshikai Yoshikai

    14th International Congress Of Immunology  2010.8 

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    Event date: 2010.8

    Presentation type:Oral presentation (general)  

    Venue:神戸ポートピアホテル   Country:Japan  

  • IL-17-producing gdT cells are important for the antitumor effect of BCG treatment against bladder tumor.

    TAKEUCHI Ario, YAMADA Hisakata, SHIBATA Kensuke, YOSHIKAI Yasunobu

    日本免疫学会  2009.12 

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    Event date: 2009.12

    Presentation type:Oral presentation (general)  

    Venue:大阪国際会議場   Country:Japan  

  • 高病原性インフルエンザウイルス(H1N1)感染で誘導される致死的肺傷害病態の解析

    NAKAMURA Risa, MAEDA Naoyoshi, NOYORI Osamu, YAMADA Hisakata, SHIBATA Kensuke, YOSHIKAI Yasunobu

    日本免疫学会  2009.12 

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    Event date: 2009.12

    Presentation type:Oral presentation (general)  

    Venue:大阪国際会議場   Country:Japan  

  • A protective role of IL-17-producing γδ T cells in lung against systemic candidiasis.

    DEJIMA Takashi, SHIBATA Kensuke, YAMADA Hisakata, YOSHIKAI Yasunobu

    日本免疫学会  2009.12 

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    Event date: 2009.12

    Presentation type:Oral presentation (general)  

    Venue:大阪国際会議場   Country:Japan  

  • CD30 ligand plays an important role in development of chronic colitis by modulating T-helper 17 differentiation

    SUN Xun, YAMADA Hisakata, SHIBATA Kensuke, MUTA Hiromi, TANI Kenzaburo, Podak Eckhard R, IWAKURA Yoichiro, YOSHIKAI Yasunobu

    日本免疫学会  2009.12 

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    Event date: 2009.12

    Presentation type:Oral presentation (general)  

    Venue:大阪国際会議場   Country:Japan  

  • Tyk2-signaling plays an impotant role in host defense against Escherichia coli through IL-23-indused IL-17 production by γδ T cells.

    NAKAMURA Risa, SHIBATA Kensuke, YAMADA Hisakata, SHIMODA Kazuya, YOSHIKAI Yasunobu

    日本免疫学会  2008.12 

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    Event date: 2008.12

    Presentation type:Symposium, workshop panel (public)  

    Venue:国立京都国際会館   Country:Japan  

  • CD30L/CD30 signaling by T-T cell interaction augment Th1 response.

    Tang Ce, YAMADA Hisakata, SHIBATA Kensuke, MUTA Hiromi, OHARA Naoya, Wajjwalku Worawidh, Podack Eckhard R., YOSHIKAI Yasunobu

    日本免疫学会  2008.12 

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    Event date: 2008.12

    Presentation type:Oral presentation (general)  

    Venue:国立京都国際会館   Country:Japan  

  • A crucial role of IL-15 in acute lung injury induced by influenza virus infection in mice.

    Naoyoshi Maeda, Ce Tang, Kensuke Shibata, Momoe Itsumi, Hisakata Yamada, Tetsuo Kase, Yasunobu Yoshikai

    日本免疫学会  2008.12 

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    Event date: 2008.12

    Presentation type:Symposium, workshop panel (public)  

    Venue:国立京都国際会館   Country:Japan  

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MISC

  • γδT細胞の機能制御と疾患

    Kensuke Shibata

    炎症と免疫   2015.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • γδ T細胞分化と機能制御

    Kensuke Shibata

    医学のあゆみ   2014.11

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-17産生gd T細胞の分化と活性化

    柴田 健輔

    臨床免疫・アレルギー科   2012.11

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Close link between development and function of γδ T cells

    Kensuke Shibata

    Microbiology and Immunology   2012.2

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • γδ T細胞と生体防御

    柴田 健輔、吉開 泰信.

    2009.5

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  • Functions of IL-17-producing γδ T cells.

    Kensuke Shibata, Yasunobu Yoshikai

    The Open Immunology Journal   2009.2

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-17とγδ型Tリンパ球

    柴田 健輔、山田 久方、吉開 泰信.

    2009.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 感染防御におけるサイトカインの役割

    柴田 健輔、山田久方、吉開泰信

    2008.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-17A産生γδ 型Tリンパ球の機能

    柴田 健輔、山田久方、吉開泰信

    2008.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Professional Memberships

  • Japanese Society for Immunology

  • Japanese Society for Host defense Research

  • 日本比較免疫学会

  • 日本細菌学会

Academic Activities

  • 座長(Chairmanship)

    日本免疫学会  ( Japan ) 2017.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本免疫学会  ( Japan ) 2013.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本生体防御学会  ( Japan ) 2012.7

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    Type:Competition, symposium, etc. 

Research Projects

  • 自己免疫性膵炎様病態自然発症マウスモデルを用いた病態制御機構の解明

    Grant number:16K08740  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • IL-17産生gdT細胞による免疫制御と治療への応用

    Grant number:22790468  2010 - 2012

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 大腸菌感染防御におけるIL-17産生γδ T細胞の役割と増殖機構の解明

    Grant number:20-04192  2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

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    Authorship:Principal investigator  Grant type:Scientific research funding

Class subject

  • 免疫学

    2013.4 - 2013.9   First semester

  • 免疫学

    2012.4 - 2012.9   First semester

  • 免疫学

    2011.4 - 2011.9   First semester

  • 免疫学

    2010.4 - 2010.9   First semester

Travel Abroad

  • 2017.5 - 2018.5

    Staying countory name 1:Korea, Republic of   Staying institution name 1:Institute for Basic Science (IBS) POSTECH Biotech Center

  • 2016.4

    Staying countory name 1:France   Staying institution name 1:Curie institute