Updated on 2024/10/04

Information

 

写真a

 
ODA YOSHINAO
 
Organization
Faculty of Medical Sciences Research Center for Human Disease Modeling Professor
Kyushu University Hospital (Joint Appointment)
Faculty of Medical Sciences Research Center for Human Disease Modeling(Joint Appointment)
School of Medicine Department of Biomedical Science(Joint Appointment)
Graduate School of Medical Sciences Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Health Care Administration and Management(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426061
Profile
Research: Surgical pathology of bone and soft tissue tumor, Multidrug resistance gene expression of human solid tumor, Oncogene and tumor suppressor gene in human sarcoma Education: Lecture and practical education of surgical and molecular pathology, macroscopic and microscopic examination of human tumor Social activities: Diagnostic pathology and cytology for the practical work in the refered hospital. President of Japanese Society of Pathology, President of Japanese Division of International Academy of Pathology

Degree

  • MD. PhD

Research History

  • 佐賀県立病院好生館 1987.6--1988.5 九州厚生年金病院 1996.6--1999.9

    佐賀県立病院好生館 1987.6--1988.5 九州厚生年金病院 1996.6--1999.9

Research Interests・Research Keywords

  • Research theme:Spatial multi-omics analysis to elucidate the tumor microenvironment of soft-tissue sarcomas and search for metabolically targeted therapies.

    Keyword:Soft tissue sarcoma, tumor microenvironment, spatial multi-omics analysis, tumor metabolism

    Research period: 2023.5 - 2023.8

  • Research theme:Investigation of novel immuno biomarker for malignant bone and soft tissue tumor

    Keyword:immunotherapy, malignant bone and soft tissue tumor, biomarker

    Research period: 2016.4 - 2020.6

  • Research theme:Systematic survey for molecular target in translocation associated and non-translocation associated soft tissue sarcoma

    Keyword:Malignant soft tissue tumor, molecular target, translocation

    Research period: 2013.4 - 2016.3

  • Research theme:Alteration of signal pathway and the possibility of molecular target therapy in malignant soft tissue tumors

    Keyword:Malignant soft tissue tumor, mTOR, STAT3, pAkt

    Research period: 2009.5 - 2012.5

  • Research theme:Ckemokine receptor and angiogenesis in malignant bone and soft tissue tumors

    Keyword:Malignant bone and soft tssue tumor, VEGF, CXCR4

    Research period: 2006.4 - 2009.5

  • Research theme:Molecular abnormalities of cell cycle regulators in malignant bone and soft-tissue tumor

    Keyword:malignant bone and soft tissue tumor, cell cycle regulator genes and protein

    Research period: 2003.4

  • Research theme:Molecular genetic abnormalities and their usefulness for diagnosis and prediction of prognosis in soft-tissue sarcomas

    Keyword:Soft tissue sarcoma, molecular pathology, prognostic factor

    Research period: 2000.4 - 2002.3

  • Research theme:Expression of multidrug resistant related genes in human malignant solid tumors

    Keyword:Malignant bone and soft tissue tumor, gynecological tumor, pediatric tumor, multidrug resistance, molecular biology

    Research period: 1996.10 - 2003.12

Awards

  • 2021年度国際会議誘致・開催貢献賞 国際会議誘致の部

    2022.2   日本政府観光局   第36回国際病理アカデミー国際会議を福岡に誘致した業績による(2026年10月開催予定)

  • 日本病理学賞

    2016.5   日本病理学会   軟部肉腫の病理病態―形態から分子生物学的アプローチへ

  • International Academy of Pathology 日本支部 2002年病理診断学術奨励賞

    2002.11   International Academy of Pathology 日本支部   Pleomorphic Leiomyosarcomaの臨床病理学的研究

  • 日本病理学会学術研究賞(A演説)(平成13年)

    2001.11   日本病理学会  

  • 日本病理学会学術奨励賞

    2000.4   日本病理学会   滑膜肉腫における分子病理学的研究

Papers

  • Dysadherin expression as a significant prognostic factor and as a determinant of histological features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression. Reviewed International journal

    Izumi T, Oda Y, Hasegawa T, Kawai A, Sonobe H, Nakanishi Y, Takahira T, Kobayashi C, Yamamoto H, Tamiya S, Yokoyama R, Hirohashi S, Iwamoto Y, Tsuneyoshi M

    Am J Surg Pathol 31; 85-94, 2007. (Corresponding)   2007.1

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  • CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: Analysis within a group of patients, all of whom developed lung metastasis. Reviewed International journal

    Oda Y, Yamamoto H, Tamiya S, Matsuda S, Tanaka K, Yokoyama R, Iwamoto Y, Tsuneyoshi M:

    Mod Pathol 19: 738-45, 2006. (corresponding)   2006.8

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  • Frequent alteration of p16INK4a/p14ARF and p53 pathways of round cell appearance in myxoid/round cell liposarcoma: Altered p53 gene and reduced p14ARF expression correlates with poor prognosis. Reviewed International journal

    Oda Y, Yamamoto H, Takahira T, Kobayashi C, Kawaguchi K, Tateishi N, Nozuka Y, Tamiya S, Tanaka K, Matsuda S, Yokoyama R, Iwamoto Y, Tsuneyoshi M:

    J Pathol 207; 410-421, 2005. (Corresponding)   207 ( 4 )   410 - 421   2005.1

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    DOI: 10.1002/path.1848

  • ATP-binding cassette superfamily transporter gene expression in human soft tissue sarcoma. Reviewed International journal

    Oda Y, Saito T, Tateishi N, Ohishi Y, Tamiya S, Yamamoto H, Yokoyama R, Uchiumi T, Iwamoto Y, Kuwano M, Tsuneyoshi M

    Int J Cancer 114: 854-862, 2005 (Corresponding)   114 ( 6 )   854 - 862   2005.1

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    DOI: 10.1002/ijc.20589

  • Low-grade fibromyxoid sarcoma versus low-grade myxofibrosarcoma in the extremities and trunk. Clinicopathologic and immunohistochemical study with special emphasis on the alteration of cell cycle regulators. Reviewed International journal

    Oda Y, Takahira T, Kawaguchi K, Yamamoto H, Tamiya S, Matsuda S, Tanaka K,wamoto Y, Tsuneyoshi M:

    Histopathology 45; 29-38, 2004 (Corresponding)   45 ( 1 )   29 - 38   2004.1

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    DOI: 10.1111/j.1365-2559.2004.01886.x

  • E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma. Reviewed International journal

    Saito T, Oda Y, Kawaguchi K, Yamamoto H, Sugimachi K, Tateishi N, Tanaka K,Matsuda S, Iwamoto Y, Ladanyi M, Tsuneyoshi M:

    Oncogene 23: 8629-8638, 2004   23 ( 53 )   8629 - 8638   2004.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.onc.1207960

  • Nuclear expression of Y box-binding protein-1 correlates with P-glycoprotein and topoisomerase II-apha expression, and poor prognosis in synovial sarcoma. Reviewed International journal

    Oda Y, Ohishi Y, Saito T, Hinoshita E, Uchiumi T, Kinukawa N, Iwamoto Y, Kohno K, Kuwano M, Tsuneyoshi M

    J Pathol 199; 251-258, 2003   199 ( 2 )   251 - 258   2003.1

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    DOI: 10.1002/path.1282

  • Alterations of cell cycle regulators in myxofibrosarcoma. With special emphasis on their prognostic implications. Reviewed International journal

    Oda Y, Takahira T, Kawaguchi K, Yamamoto H, Tamiya S, Matsuda S, Tanaka K, Kinukawa N, Iwamoto Y, Tsuneyoshi M:

    Human Pathol 34; 1035-1042, 2003   2003.1

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  • Reassessment of malignant fibrous histiocytoma of soft parts and its clinicopathologic prognostic factors. Reviewed International journal

    Oda Y, Tamiya S, Oshiro Y, Hachitanda Y, Kinukawa N, Iwamoto Y, Tsuneyoshi M

    Pathol Int 52; 595-606, 2002   2002.1

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  • ATP-binding casstte superfamily transporter gene expression in human ovarian carcinoma Reviewed International journal

    Ohishi Y, Oda Y, Uchiumi T, Kobayashi H, Hirakawa T, Miyamoto S, Kinukawa N, Nakano H, Kuwano M, Tsuneyoshi M:

    Clin Cancer Res 8; 3767-3775, 2002   8 ( 12 )   3767 - 3775   2002.1

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  • Pleomorphic leiomyosarcoma: Clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma. Reviewed International journal

    Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M

    Am J Surg Pathol 25; 1030-1038, 2001   25 ( 8 )   1030 - 1038   2001.1

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    DOI: 10.1097/00000478-200108000-00007

  • Molecular abnormalities of p53, MDM2 and H-ras in synovial sarcoma. Reviewed International journal

    Oda Y, Sakamoto A, Saito T, Kawauchi S, Iwamoto Y, Tsuneyoshi M:

    Mod Pathol 13: 994-1004, 2000.   13 ( 9 )   994 - 1004   2000.1

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    DOI: 10.1038/modpathol.3880180

  • Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma. Reviewed International journal

    Oda Y, Sakamoto A, Shinohara N, Ohga T, Uchiumi T, Kohno K, Tsuneyoshi M, Kuwano M, Iwamoto Y

    Clin Cancer Res 4: 2273-2277, 1998   4 ( 9 )   2273 - 2277   1998.1

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  • Tumor-associated neutrophils upregulate Nectin2 expression, creating the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

    Luo H., Ikenaga N., Nakata K., Higashijima N., Zhong P., Kubo A., Wu C., Tsutsumi C., Shimada Y., Hayashi M., Oyama K., Date S., Abe T., Ideno N., Iwamoto C., Shindo K., Ohuchida K., Oda Y., Nakamura M.

    Journal of Experimental and Clinical Cancer Research   43 ( 1 )   258   2024.12   ISSN:0392-9078

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    Background: Tumor-associated neutrophils (TANs) constitute an abundant component among tumor-infiltrating immune cells and have recently emerged as a critical player in pancreatic ductal adenocarcinoma (PDAC) progression. This study aimed to elucidate the pro-tumor mechanisms of TAN and identify a novel target for effective immunotherapy against PDAC. Methods: Microarray and cytokine array analyses were performed to identify the mechanisms underlying the function of TANs. Human and mouse TANs were obtained from differentiated HL-60 cells and orthotopically transplanted PDAC tumors, respectively. The interactions of TANs with cancer and cytotoxic T-cells were evaluated through in vitro co-culture and in vivo orthotopic or subcutaneous models. Single-cell transcriptomes from patients with PDAC were analyzed to validate the cellular findings. Results: Increased neutrophil infiltration in the tumor microenvironment was associated with poor survival in patients with PDAC. TANs secreted abundant amounts of chemokine ligand 5 (CCL5), subsequently enhancing cancer cell migration and invasion. TANs subpopulations negatively correlated with cytotoxic CD8+ T-cell infiltration in PDAC and promoted T-cell dysfunction. TANs upregulated the membranous expression of Nectin2, which contributed to CD8+ T-cell exhaustion. Blocking Nectin2 improved CD8+ T-cell function and suppressed tumor progression in the mouse model. Single-cell analysis of human PDAC revealed two immunosuppressive TANs phenotypes: Nectin2+ TANs and OLR1+ TANs. Endoplasmic reticulum stress regulated the protumor activities in TANs. Conclusions: TANs enhance PDAC progression by secreting CCL5 and upregulating Nectin2. Targeting the immune checkpoint Nectin2 could represent a novel strategy to enhance immunotherapy efficacy in PDAC.

    DOI: 10.1186/s13046-024-03178-6

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  • Viable tumor cell density after neoadjuvant chemotherapy assessed using deep learning model reflects the prognosis of osteosarcoma

    Kawaguchi K., Miyama K., Endo M., Bise R., Kohashi K., Hirose T., Nabeshima A., Fujiwara T., Matsumoto Y., Oda Y., Nakashima Y.

    npj Precision Oncology   8 ( 1 )   16   2024.12   ISSN:2397-768X

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    Prognosis after neoadjuvant chemotherapy (NAC) for osteosarcoma is generally predicted using manual necrosis-rate assessments; however, necrosis rates obtained in these assessments are not reproducible and do not adequately reflect individual cell responses. We aimed to investigate whether viable tumor cell density assessed using a deep-learning model (DLM) reflects the prognosis of osteosarcoma. Seventy-one patients were included in this study. Initially, the DLM was trained to detect viable tumor cells, following which it calculated their density. Patients were stratified into high and low-viable tumor cell density groups based on DLM measurements, and survival analysis was performed to evaluate disease-specific survival and metastasis-free survival (DSS and MFS). The high viable tumor cell density group exhibited worse DSS (p = 0.023) and MFS (p = 0.033). DLM-evaluated viable density showed correct stratification of prognosis groups. Therefore, this evaluation method may enable precise stratification of the prognosis in osteosarcoma patients treated with NAC.

    DOI: 10.1038/s41698-024-00515-y

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  • Rare presentation of a primary intraosseous glomus tumor in the humerus of a teenager

    Kawaguchi K., Kohashi K., Setsu N., Sagiyama K., Endo M., Iwasaki T., Nakashima Y., Oda Y.

    Skeletal Radiology   53 ( 11 )   2529 - 2535   2024.11   ISSN:03642348

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    A glomus tumor is a benign mesenchymal tumor comprised of cells that resemble the perivascular modified smooth muscle cells of the glomus body. Glomus tumors typically appear in the superficial lesions of the soft tissue in the extremities, such as the subungual region. However, their occurrence in the bone is rare, with only about 30 cases reported to date. Half of these cases involved the distal phalanges of the fingers or toes, with only three reported cases involving the long bones. Here, we present the first case, a primary glomus tumor in the humerus of a 14-year-old female. An osteolytic and cystic lesion was detected after a pathological fracture occurred during exercise. Despite the tumor’s large size, no pathological findings indicated malignancy. The fracture healed through conservative treatment, while the tumor was effectively managed with curettage. Appropriate medical care can be provided to patients by focusing on pathological findings.

    DOI: 10.1007/s00256-024-04604-8

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  • Translocation in bone and soft tissue sarcomas: a comprehensive epidemiological investigation.

    9 ( 10 )   103726   2024.9

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    DOI: 10.1016/j.esmoop.2024.103726

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  • Combined Autophagy Inhibition and Dendritic Cell Recruitment Induces Antitumor Immunity and Enhances Immune Checkpoint Blockade Sensitivity in Pancreatic Cancer.

    Oyama K, Nakata K, Tsutsumi C, Hayashi M, Zhang B, Mochida Y, Shinkawa T, Hirotaka K, Zhong P, Date S, Luo H, Kubo A, Higashijima N, Yamada Y, Abe T, Ideno N, Koikawa K, Iwamoto C, Ikenaga N, Ohuchida K, Onishi H, Morisaki T, Kuba K, Oda Y, Nakamura M

    Cancer research   2024.9   ISSN:0008-5472

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    DOI: 10.1158/0008-5472.CAN-24-0830

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  • TAK1 Promotes an Immunosuppressive Tumor Microenvironment through Cancer-Associated Fibroblast Phenotypic Conversion in Pancreatic Ductal Adenocarcinoma.

    Sheng N, Shindo K, Ohuchida K, Shinkawa T, Zhang B, Feng H, Yamamoto T, Moriyama T, Ikenaga N, Nakata K, Oda Y, Nakamura M

    Clinical cancer research : an official journal of the American Association for Cancer Research   2024.9   ISSN:1078-0432

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    DOI: 10.1158/1078-0432.CCR-24-1004

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  • Clinical Significance of SIRPα Expression on Tumor-Associated Macrophages in Patients with Lung Squamous Cell Carcinoma

    Nagano T., Takada K., Narutomi F., Kinoshita F., Akamine T., Kohno M., Shimokawa M., Takenaka T., Oda Y., Yoshizumi T.

    Annals of Surgical Oncology   31 ( 9 )   6309 - 6319   2024.9   ISSN:10689265

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    Background: Signal-regulatory protein alpha (SIRPα) is an immune checkpoint molecule expressed on macrophages that functions to inhibit phagocytosis by binding to CD47 expressed on tumor cells. SIRPα has attracted increasing attention as a novel target for cancer immunotherapy; however, the expression and immune function of SIRPα in lung squamous cell carcinoma (LUSC) remain unclear. Therefore, this study aimed to identify the clinical importance of SIRPα expression in LUSC and to explore the factors that elevate SIRPα expression. Patients and Methods: Primary LUSC specimens surgically resected from 172 patients underwent immunohistochemical evaluation of the association of SIRPα expression on tumor-associated macrophages with clinicopathological features and clinical outcomes. Furthermore, we analyzed the association of SIRPα expression with tumor-infiltrating lymphocytes and the expression of programmed cell death ligand 1 (PD-L1). In vitro, monocytes were treated with cytokines, and SIRPα protein expression was assessed by flow cytometry. Results: There were no differences in SIRPα expression and clinicopathological factors. High SIRPα expression was significantly associated with PD-L1-positive expression, and high CD8, PD-1, and CD163 expression. The high SIRPα expression group showed significantly shorter recurrence-free survival (RFS) and overall survival (OS). On multivariate analysis, high SIRPα expression was an independent poor prognostic factor for RFS and OS. The expression of SIRPα protein in monocytes was upregulated by treatment with IFNγ. Conclusion: Our analysis revealed that high SIRPα expression significantly predicts poor prognosis in patients with surgically resected LUSC.

    DOI: 10.1245/s10434-024-15649-3

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  • Association between Vascular Calcification and Intraplaque Hemorrhage in Coronary Atherosclerosis from Autopsy: The Hisayama Study. Reviewed International journal

    Nakano T, Kitamura H, Hata J, Maki K, Oda Y, Kitazono T, Ninomiya T.

    J Atheroscler Thromb.    31 ( 8 )   1225 - 1237   2024.8

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    DOI: 10.5551/jat.64394.

  • Papillary renal neoplasm with reverse polarity has low frequency of alterations in chromosomes 7, 17, and Y

    Kiyozawa D., Iwasaki T., Takamatsu D., Kohashi K., Miyamoto T., Fukuchi G., Eto M., Yamashita M., Oda Y.

    Virchows Archiv   485 ( 2 )   299 - 306   2024.8   ISSN:09456317

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    In papillary renal neoplasm with reverse polarity (PRNRP), the status of chromosomal copy number alterations, especially chromosomes 7/17 gain and chromosome Y loss, has remained controversial. In the literatures, there is a discrepancy among the results of chromosomal alteration in PRNRP depending on the analytical methods. Here, we comprehensively analyzed the status of chromosomal abnormalities in PRNRP. Nineteen PRNRP cases were analyzed by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC), five of which were additionally subjected to array-based comparative genomic hybridization (aCGH) analysis. Fifteen cases of PRCC were used as controls. From the aCGH results, no genome copy number abnormalities were found in the five PRNRP cases. By FISH, numbers of nuclei with abnormal chromosomal signals in PRNRP (centromere 7 gain: 11–21% of nuclei, centromere 17 gain: 11% of nuclei, centromere Y loss: 14–31% of nuclei) were similar to those in non-neoplastic tubular cells (centromere 7 gain: 11–15% of nuclei, centromere 17 gain: 12–15% of nuclei, centromere Y loss: 13–45% of nuclei). c-MET immunohistochemical overexpression, a substitute marker for chromosome 7 trisomy, was observed in 0 of 19 PRNRP cases, consistent with the analyses by aCGH and NGS regarding chromosome 7 gain. Taken together, the frequency of chromosomal alterations in PRNRP is similar to that in non-neoplastic tubular cells, and lower than that in PRCC. Our data suggest that PRNRP has a different tumorigenesis and is a distinct entity from PRCC.

    DOI: 10.1007/s00428-024-03840-6

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  • Expression of Forkhead Box M1 and Anticancer Effects of FOXM1 Inhibition in Epithelioid Sarcoma

    Shibui Y., Kohashi K., Hino Y., Tamaki A., Kinoshita I., Yamamoto H., Nakashima Y., Tajiri T., Oda Y.

    Laboratory Investigation   104 ( 8 )   102093   2024.8   ISSN:00236837

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    Epithelioid sarcoma (ES) is a rare aggressive sarcoma that, unlike most soft-tissue sarcomas, shows a tendency toward local recurrence and lymph node metastasis. Novel antitumor agents are needed for ES patients. Forkhead box transcription factor 1 (FOXM1) is a member of the Forkhead transcription factor family and is associated with multiple oncogenic functions; FOXM1 is known to be overexpressed and correlated with pathogenesis in various malignancies. In this study, we immunohistochemically analyzed FOXM1 expression levels and their clinical, clinicopathologic, and prognostic significance in 38 ES specimens. In addition, to investigate potential correlations between FOXM1 downregulation and oncologic characteristics, we treated ES cell lines with thiostrepton, a naturally occurring antibiotic that inhibits both small interfering RNA (siRNA) and FOXM1. In the analyses using ES samples, all 38 specimens were diagnosed as positive for FOXM1 by immunohistochemistry. We separated specimens into high (n = 19) and low (n = 19) FOXM1–protein expression groups by staining index score, and into large (n = 12), small (n = 25), and unknown (n = 1) tumor-size groups using a cutoff of 5 cm maximum diameter. Although there were significantly more samples with high FOXM1 expression in the large tumor group (P = .013), there were no significant differences with respect to age (P = 1.00), gender (P = .51), primary site of origin (P = .74), histologic subtypes (P = 1.00), depth (P = .74), or survival rate (P = .288) between the high and low FOXM1–protein expression groups. In the in vitro experiments using ES cell lines, FOXM1 siRNA and thiostrepton successfully downregulated FOXM1 mRNA and protein expression. Furthermore, downregulation of FOXM1 inhibited cell proliferation, drug resistance against chemotherapeutic agents, migration, and invasion and caused cell cycle arrest in the ES cell lines. Finally, cDNA microarray analysis data showed that FOXM1 regulated cIAP2, which is one of the apoptosis inhibitors activated by the TNFα-mediated NF-κB pathway. In conclusion, the FOXM1 gene may be a promising therapeutic target for ES.

    DOI: 10.1016/j.labinv.2024.102093

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  • Geriatric nutritional risk index as a predictor for surgical site infection in malignant musculoskeletal tumours of the trunk.

    Shiraishi S, Fujiwara T, Nabeshima A, Iida K, Endo M, Matsumoto Y, Oda Y, Nakashima Y

    Japanese journal of clinical oncology   2024.7   ISSN:0368-2811

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    DOI: 10.1093/jjco/hyae095

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  • Effect of HLA Genotype on Anti-PD-1 Antibody Treatment for Advanced Renal Cell Carcinoma in the SNiP-RCC Study

    Tanegashima T., Shiota M., Fujiyama N., Narita S., Habuchi T., Fukuchi G., Takamatsu D., Oda Y., Miyake H., Takahashi M., Oya M., Tsuchiya N., Masumori N., Matsuyama H., Obara W., Shinohara N., Fujimoto K., Nozawa M., Ohba K., Ohyama C., Hashine K., Akamatsu S., Kamba T., Mita K., Gotoh M., Tatarano S., Fujisawa M., Tomita Y., Mukai S., Ito K., Tokunaga S., Eto M.

    Journal of Immunology   213 ( 1 )   23 - 28   2024.7   ISSN:00221767

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    Immune checkpoint blockade therapies are widely used for cancer treatment, including advanced renal cell carcinoma (RCC). This study aimed to investigate the impact of zygosity in HLA genes and individual HLA genotypes on the efficacy of an anti-PD-1 Ab, nivolumab, in treating advanced RCC. Patient enrollment was conducted across 23 institutions in Japan from August 19, 2019, to September 30, 2020, with follow-up concluding on March 31, 2021. HLA genotype imputation of HLA-A, B, and C, DQB1, and DRB1 loci was performed. Among 222 patients, the presence of at least one homozygosity of the HLA-II allele significantly improved the best objective response (hazard ratio, 0.34; 95% confidence interval, 0.21-0.96; p 5 0.042). The HLA evolutionary divergence (HED) of the HLA-A and HLA-B loci was higher than the HLA-C (p < 0.0001 and p < 0.0001, respectively), with high HED of the HLA-B locus correlating to clinical benefits in nivolumab treatment (hazard ratio, 0.44; 95% confidence interval, 0.21-0.90; p 5 0.024) and improving cancer-specific survival compared with the low group (p 5 0.0202). Additionally, high HED of the HLA-B locus was correlated with the number of infiltrated CD8+ cells in the tumor microenvironment (correlation coefficient, 0.4042). These findings indicate that the diversity of the HLA-B locus plays a significant role in the anti-tumor effect of nivolumab treatment in advanced RCC, potentially offering insights for improved risk stratification in nivolumab treatment and leading to better medical management of advanced RCC. The Journal of Immunology, 2024, 213: 23-28.

    DOI: 10.4049/jimmunol.2300308

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  • A novel objective pathologic criterion for isolated hypoganglionosis. Reviewed International journal

    Tamaki A, Kohashi K, Yoshimaru K, Hino Y, Hamada H, Kawakubo N, Taguchi T, Tajiri T, Oda Y.

    Am J Surg Pathol.   48 ( 7 )   803 - 812   2024.7

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  • Immunohistochemical p16 overexpression and Rb loss correlate with high-risk human papillomavirus infection in endocervical adenocarcinomas. Reviewed International journal

    Yasutake N, Yamamoto H, Kuga R, Jiromaru R, Hongo T, Katayama Y, Sonoda K, Yahata H, Kato K, Oda Y.

    Histopathology.   84 ( 7 )   1178 - 1191   2024.6

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    DOI: doi: 10.1111/his.15169.

  • FOXM1 and CHD4 expression is associated with chemoresistance in hepatoblastoma.

    Hino Y, Kohashi K, Tamaki A, Kawakubo N, Hamada H, Fukuhara M, Shibui Y, Tajiri T, Oda Y.

    Pathol Res Pract.   258   155348   2024.6

  • Clinicopathological significance of microsatellite instability and immune escape mechanism in patients with gastric solid-type poorly differentiated adenocarcinoma. Reviewed International journal

    Umekita S, Kiyozawa D, Kohashi K, Kawatoko S, Sasaki T, Ihara E, Oki E, Nakamura M, Ogawa Y, Oda Y.

    Gastric Cancer.   27 ( 3 )   484 - 494   2024.5

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    DOI: doi: 10.1007/s10120-024-01474-w

  • Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells. Reviewed International journal

    Zhong P, Nakata K, Oyama K, Higashijima N, Sagara A, Date S, Luo H, Hayashi M, Kubo A, Wu C, He S, Yamamoto T, Koikawa K, Iwamoto C, Abe T, Ikenaga N, Ohuchida K, Morisaki T, Oda Y, Kuba K, Nakamura M.

    J Exp Clin Cancer Res.   43 ( 1 )   138   2024.5

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    DOI: doi: 10.1186/s13046-024-03060-5.

  • Single-Cell and Spatial Transcriptomics Analysis of Human Adrenal Aging. Reviewed International journal

    Iwahashi N, Umakoshi H, Fujita M, Fukumoto T, Ogasawara T, Yokomoto-Umakoshi M, Kaneko H, Nakao H, Kawamura N, Uchida N, Matsuda Y, Sakamoto R, Seki M, Suzuki Y, Nakatani K, Izumi Y, Bamba T, Oda Y, Ogawa Y.

    Mol Metab.   84   101954   2024.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molmet.2024.101954

  • Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine. Reviewed International journal

    Imazu N, Torisu T, Yokote A, Umeno J, Kawasaki K, Fujioka S, Matsuno Y, Nagasue T, Kawatoko S, Moriyama T, Nitahata T, Uchida Y, Aihara S, Taniguchi Y, Oda Y, Kitazono T.

    J Gastroenterol.   59 ( 8 )   682 - 698   2024.5

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    DOI: 10.1007/s00535-024-02104-z

  • The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia. Reviewed International journal

    Ikeda H, Ihara E, Takeya K, Mukai K, Onimaru M, Ouchida K, Hata Y, Bai X, Tanaka Y, Sasaki T, Saito F, Eto M, Nakayama J, Oda Y, Nakamura M, Inoue H, Ogawa Y.

    J Gastroenterol.   59 ( 5 )   361 - 375   2024.5

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    DOI: doi: 10.1007/s00535-024-02088-w

  • Microenvironmental changes in familial adenomatous polyposis during colorectal cancer carcinogenesis. Reviewed International journal

    Hisano K, Mizuuchi Y, Ohuchida K, Kawata J, Torata N, Zhang J, Katayama N, Tsutsumi C, Nakamura S, Okuda S, Otsubo Y, Tamura K, Nagayoshi K, Ikenaga N, Shindo K, Nakata K, Oda Y, Nakamura M. 

    Cancer Lett.   589   216822   2024.5

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  • Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis. Reviewed International journal

    Hashimoto M, Kojima Y, Sakamoto T, Ozato Y, Nakano Y, Abe T, Hosoda K, Saito H, Higuchi S, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Hata T, Nagayama S, Kagawa K, Goto Y, Utou M, Gamachi A, Imamura K, Kuze Y, Zenkoh J, Suzuki A, Takahashi K, Niida A, Hirose H, Hayashi S, Koseki J, Fukuchi S, Murakami K, Yoshizumi T, Kadomatsu K, Tobo T, Oda Y, Uemura M, Eguchi H, Doki Y, Mori M, Oshima M, Shibata T, Suzuki Y, Shimamura T, Mimori K.

    EBioMedicine.   103   105102   2024.5

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    DOI: 10.1016/j.ebiom.2024.105102

  • Immune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8+ T cell infiltration. Reviewed International journal

    Kanahori M, Shimada E, Matsumoto Y, Endo M, Fujiwara T, Nabeshima A, Hirose T, Kawaguchi K, Oyama R, Oda Y, Nakashima Y.

    Br J Cancer.   130 ( 7 )   1083 - 1095   2024.4

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    DOI: doi: 10.1038/s41416-024-02576-z.

  • Association between hypothalamic Alzheimer's disease pathology and body mass index: The Hisayama study. Reviewed International journal

    Yagita K, Honda H, Ohara T, Koyama S, Noguchi H, Oda Y, Yamasaki R, Isobe N, Ninomiya T.

    (Online ahead of print.) Neuropathology.   2024.4

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    DOI: doi: 10.1111/neup.12974.

  • Impact of ACSL4 on the prognosis of hepatocellular carcinoma: Association with cancer-associated fibroblasts and the tumour immune microenvironment. Reviewed International journal

    Toshida K, Itoh S, Iseda N, Tomiyama T, Yoshiya S, Toshima T, Liu YC, Iwasaki T, Okuzaki D, Taniguchi K, Oda Y, Mori M, Yoshizumi T.

    Liver Int.   44 ( 4 )   1011 - 1023   2024.4

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    DOI: doi: 10.1111/liv.15839.

  • Patient-derived organoids of pancreatic ductal adenocarcinoma for subtype determination and clinical outcome prediction. Reviewed International journal

    Matsumoto K, Fujimori N, Ichihara K, Takeno A, Murakami M, Ohno A, Kakehashi S, Teramatsu K, Ueda K, Nakata K, Sugahara O, Yamamoto T, Matsumoto A, Nakayama KI, Oda Y, Nakamura M, Ogawa Y.

    J Gastroenterol.   59 ( 7 )   629 - 640   2024.4

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    DOI: 10.1007/s00535-024-02103-0

  • Clinical features and oncological outcomes of bladder cancer microsatellite instability

    Nagakawa S., Shiota M., Takamatsu D., Tsukahara S., Mastumoto T., Blas L., Inokuchi J., Oda Y., Eto M.

    International Journal of Urology   31 ( 4 )   438 - 445   2024.4   ISSN:09198172

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    Objectives: Excellent anticancer effect for solid tumors with microsatellite instability (MSI)-high by anti-PD-1 antibody has been reported. In this study, we investigated the clinical impact of MSI status in bladder cancer. Methods: This study included 205 Japanese patients who underwent transurethral resection for bladder cancer between 2005 and 2021. The prevalence rates of microsatellite stable (MSS), MSI-low (MSI-L), and MSI-high (MSI-H) were determined using molecular testing. We examined the association of MSI status (MSS versus MSI-L/H) with clinicopathological characteristics and oncological outcomes. Results: MSI-L/H tumors were associated with higher T-category in non-muscle invasive bladder cancer (NMIBC). Additionally, MSI-L/H tumors were associated with a higher risk of intravesical recurrence in NMIBC patients treated with intravesical bacillus Calmette-Guérin (BCG) but not with non-BCG therapy. Conclusions: This study suggested that the MSI status might serve as a predictive marker for intravesical recurrence after BCG intravesical therapy in NMIBC and highlighted an unmet need for an alternative treatment in patients with MSI-L/H tumors.

    DOI: 10.1111/iju.15370

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  • Immature stroma and high infiltration of CD15+ cells are predictive markers of poor prognosis in different subsets of patients with pancreatic cancer. Reviewed International journal

    Yamada Y, Yamamoto T, Tsutsumi C, Matsumoto T, Noguchi S, Shimada Y, Nakata K, Ohuchida K, Nakamura M, Oda Y.

    Cancer Sci.   115 ( 3 )   1001 - 1013   2024.3

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    DOI: doi: 10.1111/cas.16060.

  • DDIT3-amplified or low-polysomic pleomorphic sarcomas without MDM2 amplification: Clinicopathological review and immunohistochemical profile of nine cases. Reviewed International journal

    Mori T, Iwasaki T, Sonoda H, Kawaguchi K, Tomonaga T, Furukawa H, Sato C, Shiraishi S, Taguchi K, Tamiya S, Yoneda R, Oshiro Y, Matsunobu T, Abe C, Kuboyama Y, Ueki N, Kohashi K, Yamamoto H, Nakashima Y, Oda Y.

    Hum Pathol.   145   56 - 62   2024.3

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    DOI: 10.1016/j.humpath.2024.02.007.

  • Clinical and Prognostic Significance of Glutathione Peroxidase 2 in Lung Adenocarcinoma. Reviewed International journal

    Hashinokuchi A, Matsubara T, Ono Y, Shunichi S, Matsudo K, Nagano T, Kinoshita F, Akamine T, Kohno M, Takenaka T, Oda Y, Yoshizumi T.

    (Online ahead of print.) Ann Surg Oncol.   2024.3

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    DOI: doi: 10.1245/s10434-024-15116-z

  • Steroids-producing nodules: a two-layered adrenocortical nodular structure as a precursor lesion of cortisol-producing adenoma. Reviewed International journal

    Fukumoto T, Umakoshi H, Iwahashi N, Ogasawara T, Yokomoto-Umakoshi M, Kaneko H, Fujita M, Uchida N, Nakao H, Kawamura N, Matsuda Y, Sakamoto R, Miyazawa T, Seki M, Eto M, Oda Y, Suzuki Y, Ogawa S, Ogawa Y.

    (Online ahead of print.) EBioMedicine.   2024.3

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    DOI: doi: 10.1016/j.ebiom.2024.105087.

  • Gene amplification of chromatin remodeling factor SMARCC2 and low protein expression of ACTL6A are unfavorable factors in ovarian high‑grade serous carcinoma. Reviewed International journal

    Magarifuchi N, Iwasaki T, Katayama Y, Tomonaga T, Nakashima M, Narutomi F, Kato K, Oda Y.

    Oncol Lett.   27 ( 5 )   196   2024.3

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  • Nuclear morphological atypia in biopsy accurately reflects the prognosis of myxoid liposarcoma. Reviewed International journal

    Kawaguchi K, Kohashi K, Iwasaki T, Mori T, Furukawa H, Sato C, Sonoda H, Shiraishi S, Endo M, Nakashima Y, Oda Y.

    (Online ahead of print.) Virchows Arch.   2024.3

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    DOI: doi: 10.1007/s00428-024-03796-7.

  • Tumor-infiltrating monocytic myeloid-derived suppressor cells contribute to the development of an immunosuppressive tumor microenvironment in gastric cancer. Reviewed International journal

    Tsutsumi C, Ohuchida K, Katayama N, Yamada Y, Nakamura S, Okuda S, Otsubo Y, Iwamoto C, Torata N, Horioka K, Shindo K, Mizuuchi Y, Ikenaga N, Nakata K, Nagai E, Morisaki T, Oda Y, Nakamura M.

    Gastric Cancer.   27 ( 2 )   248 - 262   2024.3

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    DOI: doi: 10.1007/s10120-023-01456-4.

  • MicroRNA-20a in extracellular vesicles derived from duodenal fluid is a possible biomarker for pancreatic ductal adenocarcinoma. Reviewed International journal

    Taniguchi T, Ideno N, Araki T, Miura S, Yamamoto M, Nakafusa T, Higashijima N, Yamamoto T, Tamura K, Nakamura S, Abe T, Ikenaga N, Nakata K, Ohuchida K, Oda Y, Ohtsuka T, Nakamura M.

    DEN Open.   4 ( 1 )   e333   2024.3

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    DOI: doi: 10.1002/deo2.333.

  • Comparison of diagnostic performance of radiologist- and AI-based assessments of T2-FLAIR mismatch sign and quantitative assessment using synthetic MRI in the differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, IDH-mutant and 1p/19q-codeleted. Reviewed International journal

    Kikuchi K, Togao O, Yamashita K, Momosaka D, Kikuchi Y, Kuga D, Yuhei S, Fujioka Y, Narutomi F, Obara M, Yoshimoto K, Ishigami K.

    Neuroradiology.   66 ( 3 )   333 - 341   2024.3

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    DOI: doi: 10.1007/s00234-024-03288-0.

  • FOXM1: a new therapeutic target of extramammary Paget disease. Reviewed International journal

    Ito T, Tanaka Y, Kaku‑Ito Y, Oda Y, Nakahara T.

    Sci Rep.   14 ( 1 )   4048   2024.2

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  • Prognostic evaluation of the Ki-67 labeling system in histological grading of non-small round cell sarcoma: a supplementary analysis of a randomized controlled trial, JCOG1306. Reviewed International journal

    Sugita S, Tanaka K, Oda Y, Nojima T, Konishi N, Machida R, Kita R, Fukuda H, Ozaki T, Hasegawa T.

    (Online ahead of print.) Jpn J Clin Oncol.   2024.2

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    DOI: doi: 10.1093/jjco/hyae020

  • Multiparametric assessment of microvascular invasion in hepatocellular carcinoma using gadoxetic acid-enhanced MRI. Reviewed International journal

    Fujita N, Ushijima Y, Ishimatsu K, Okamoto D, Wada N, Takao S, Murayama R, Itoyama M, Harada N, Maehara J, Oda Y, Ishigami K, Nishie A.

    Abdom Radiol (NY).   49 ( 5 )   1467 - 1478   2024.2

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    DOI: 10.1007/s00261-023-04179-3

  • Complete reduction surgery of a huge recurrent adult granulosa cell tumor after neoadjuvant chemotherapy. Reviewed International journal

    Tokui H, Yahata H, Okabe Y, Magarifuchi N, Maenohara S, Hachisuga K, Tomonobe H, Kodama K, Yagi H, Yasunaga M, Onoyama I, Asanoma K, Oda Y, Nakamura M, Kato K.

    Int Cancer Conf J.   13 ( 2 )   162 - 166   2024.2

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    DOI: doi: 10.1007/s13691-024-00659-5.

  • Comparative analyses of tumour immune microenvironment between collecting duct carcinoma and fumarate hydratase-deficient renal cell carcinoma. Reviewed International journal

    Kiyozawa D, Kohashi K, Takamatsu D, Umekita S, Eto M, Kinjo M, Nishiyama K, Taguchi K, Oshiro Y, Kuboyama Y, Oda Y.

    J Clin Pathol.   77 ( 2 )   105 - 110   2024.1

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    DOI: doi: 10.1136/jcp-2022-208589.

  • Viable tumor cell density after neoadjuvant chemotherapy assessed using deep learning model reflects the prognosis of osteosarcoma. Reviewed International journal

    Kawaguchi K, Miyama K, Endo M, Bise R, Kohashi K, Hirose T, Nabeshima A, Fujiwara T, Matsumoto Y, Oda Y, Nakashima Y.

    NPJ Precis Oncol.   8 ( 1 )   16   2024.1

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    DOI: doi: 10.1038/s41698-024-00515-y.

  • Impact of TP53-induced glycolysis and apoptosis regulator on malignant activity and resistance to ferroptosis in intrahepatic cholangiocarcinoma. Reviewed International journal

    Toshida K, Itoh S, Iseda N, Izumi T, Yoshiya S, Toshima T, Ninomiya M, Iwasaki T, Oda Y, Yoshizumi T.

    Cancer Sci.   115 ( 1 )   170 - 183   2024.1

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    DOI: doi: 10.1111/cas.15981.

  • The Association of Transferrin Receptor with Prognosis and Biologic Role in Intrahepatic Cholangiocarcinoma

    Toshida K., Itoh S., Iseda N., Izumi T., Bekki Y., Yoshiya S., Toshima T., Iwasaki T., Oda Y., Yoshizumi T.

    Annals of Surgical Oncology   2024   ISSN:10689265

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    Background: Ferroptosis is a cell death caused by iron-dependent accumulation of lipid peroxidation. Transferrin receptor (TFR) is a ferroptosis-related protein responsible for iron transport. The detailed biologic role of TFR in intrahepatic cholangiocarcinoma (ICC) is not fully elucidated. Methods: The study enrolled 92 ICC patients who had undergone hepatic resection. Immunohistochemistry (IHC) assays were performed for TFR protein expression. The regulation of malignant activity and the effect on sensitivity to the ferroptosis-inducer artesunate by TFR were investigated in vitro. Results: Using IHC staining, 23 patients were categorized as TFR-positive. The TFR-positive group had a significantly larger tumor size and more microscopic vascular invasion. In the multivariate analysis, TFR positivity was an independent poor prognostic factor. In vitro TFR-knockdown (KD) significantly decreased the intracellular iron levels and the cell proliferation, migration, and invasion rates. Artesunate treatment significantly decreased cell viability, whereas cisplatin promoted ferroptosis. When iron transport into cells was inhibited by TFR-KD, ferroptosis was significantly suppressed. Expression of PD-L1 was induced by cisplatin, with a further increase observed when artesunate and cisplatin were used in combination. Conclusions: Transferrin receptor is a poor prognostic factor for ICC and contributes to sensitivity to ferroptosis.

    DOI: 10.1245/s10434-024-16065-3

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  • Results of the JRS-I LRA0401 and LRB0402 Japan Rhabdomyosarcoma Study Group trials for low-risk embryonal rhabdomyosarcoma

    Hosoi H., Miyachi M., Teramukai S., Sakabayashi S., Tsuchiya K., Kuwahara Y., Onodera R., Matsuyama K., Yokota I., Hojo H., Okita H., Hata J.I., Hamasaki M., Tsuneyoshi M., Oda Y., Nakazawa A., Kato M., Takimoto T., Horibe K., Hara J.I., Suita S., Hanada R., Masaki H., Nozaki M., Ikeda H., Kishimoto S., Kaneko M., Kawai A., Morikawa Y.

    International Journal of Clinical Oncology   2024   ISSN:13419625

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    Background: Failure-free survival (FFS) rates of low-risk patients with rhabdomyosarcoma improved in Intergroup Rhabdomyosarcoma Study IV after the escalation of cyclophosphamide total dose to 26.4 g/m2. However, this dose may increase the risk of adverse events, including infertility, in some patients. The JRS-I LRA0401 and LRB0402 protocols aimed to reduce the cyclophosphamide dose to 9.6 g/m2 and 17.6 g/m2, respectively, without decreasing the FFS rates. Methods: Subgroup-A patients received eight cycles (24 weeks) of vincristine, actinomycin D, and 1.2 g/m2/cycle cyclophosphamide. Subgroup-B patients received eight cycles (24 weeks) of vincristine, actinomycin D, and 2.2 g/m2/cycle cyclophosphamide, followed by six cycles (24 weeks) of vincristine and actinomycin D. Group II/III patients in both subgroups received radiotherapy. Results: In subgroup A (n = 12), the 3-year FFS rate was 83% (95% confidence interval [CI], 48–96), and the 3-year overall survival (OS) rate was 100%. Only one isolated local recurrence was observed (8.3%). There were no unexpected grade-4 toxicities and no deaths. In subgroup B (n = 16), the 3-year FFS and OS rates were 88% (95% CI, 59–97) and 94% (95% CI, 63–99), respectively. There were no unexpected grade 4 toxicities and no deaths. Conclusions: Shorter duration therapy using vincristine, actinomycin D, and lower dose cyclophosphamide with or without radiotherapy for patients with low-risk subgroup A rhabdomyosarcoma (JRS-I LRA0401 protocol) and moderate reduction of cyclophosphamide dose for patients with low-risk subgroup B rhabdomyosarcoma (JRS-I LRB0402 protocol) did not compromise FFS.

    DOI: 10.1007/s10147-024-02608-x

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  • Reappraisal of bone and soft tissue cytopathology classification using the modified Milan system

    Naka M., Yamamoto H., Kohashi K., Iwasaki T., Mori T., Nogami M., Ookubo F., Higuchi K., Motoi T., Oda Y.

    Cancer Cytopathology   2024   ISSN:1934662X

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    Background: A standardized reporting system for bone and soft tissue tumor cytopathology has not yet been established. The objective of this study was to explore the potential utility of a classification modified from the Milan System for Salivary Gland Cytopathology and compared it with the upcoming World Health Organization (WHO) system for fine-needle aspiration of soft tissue lesions. Methods: The authors reviewed 285 cytology cases of bone/joint (n = 173) and soft tissue (n = 112) lesions, scoring each within diagnostic categories. The results were compared with histologic diagnoses and the risk of malignancy (ROM) for each category, and diagnostic reliability was analyzed. Results: All 285 cases were successfully classified into one of the following categories: nondiagnostic (6.3%), non-neoplastic (11.9%), atypia of uncertain significance (11.9%), benign neoplasm (5.6%), bone and soft tissue neoplasm of uncertain malignant potential (25.3%), suspicious for malignancy (1.4%), and malignant (37.5%). The ROM was 44.4% (eight of /18 cases) in nondiagnostic, 0% (zero of 34 cases) in non-neoplastic, 32.4% (11 of 34 cases) in atypia of uncertain significance, 0% (zero of 16 cases) in benign neoplasm, 16.7% (12 of 72 cases) in bone and soft tissue neoplasm of uncertain malignant potential, 75.0% (three of four cases) in suspicious for malignancy, and 100% (107 of 107 cases) in malignant categories. Using the WHO system, the proportion and ROM of the benign category (non-neoplastic and benign neoplasm) was 17.5% and 0%, respectively. Among benign and malignant lesions, the diagnostic accuracy, sensitivity, and specificity for detecting malignancy were 99.4%, 100%, and 98.0%, respectively. Conclusions: The modified Milan system as well as the WHO system may be a useful cytopathologic classification tool for both bone and soft tissue lesions.

    DOI: 10.1002/cncy.22888

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  • CD155 Expression in Early-Stage Lung Adenocarcinoma

    Matsudo K., Takada K., Kinoshita F., Hashinokuchi A., Nagano T., Akamine T., Kohno M., Takenaka T., Shimokawa M., Oda Y., Yoshizumi T.

    Annals of Thoracic Surgery   2024   ISSN:00034975

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    Background: Cluster of differentiation (CD) 155 is a transmembrane protein that belongs to the nectin-like molecule family, which is widely overexpressed in several types of cancer. However, the clinical significance of CD155 in pathologic stage I lung adenocarcinoma remains poorly understood. Methods: We analyzed 320 patients diagnosed with pathologic stage I lung adenocarcinoma who underwent surgical treatment at Kyushu University Hospital between 2006 and 2015. The number of tumor cells expressing CD155 was assessed by immunohistochemistry, and patients were categorized into high and low CD155 expression groups. We compared the clinical and pathologic characteristics and clinical outcomes between these groups. Results: Mutation status of the epidermal growth factor receptor gene (EGFR) was determined in 237 patients. A total of 106 patients (33.1%) had EGFR wild-type, and 131 patients (40.9%) had EGFR mutant-type. CD155 expression was classified as high in 77 patients (24.1%) and as low in 243 (75.9%) as low. Multivariate analysis identified pleural invasion and EGFR wild-type as independent predictors of high CD155 expression. The Kaplan-Meier plot demonstrated significantly poorer recurrence-free survival and overall survival in the high CD155 group compared with the low CD155 group. Multivariate analysis showed high CD155 expression was an independent poor prognostic factor for recurrence-free and overall survival. Subgroup analyses revealed that a prognostic difference related to CD155 expression was observed only in patients with EGFR wild-type but not in those with EGFR mutant-type. Conclusions: Our findings suggest that high expression of CD155 is associated with EGFR wild-type and could serve as a valuable prognostic marker in pathologic stage I lung adenocarcinoma, particularly in cases without EGFR mutation.

    DOI: 10.1016/j.athoracsur.2024.05.042

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  • A Case of Myxoid Pleomorphic Liposarcoma with Rhabdoid Cells: A Diagnostic Pitfall

    Arai T., Kato I., Kawabata Y., Tsujimoto S., Ishikawa Y., Kato S., Takeyama M., Yamanaka S., Kohashi K., Oda Y., Fujii S.

    International Journal of Surgical Pathology   32 ( 7 )   1339 - 1344   2024   ISSN:10668969

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    Myxoid pleomorphic liposarcoma (MPLS) is an extremely rare tumor listed in the fifth edition of the WHO classification (2020). Histologically, it mainly comprises a mixture of myxoid and pleomorphic liposarcoma-like components. Genetically, it lacks FUS/EWSR1::DDIT3 fusion and MDM2 amplification. Herein, we describe an example of MPLS with rhabdoid cells in a 10-year-old girl who presented with a growing mass in the right inguinal region. The specimen from the wide excision measured 68 mm × 55 mm × 43 mm, and a circumscribed and lobulated mass was observed in the subcutaneous tissue. Histologically, oval-to-short, spindle-shaped, proliferating tumor cells with moderate nuclear atypia and mesh-like capillaries against a myxoid background were noted. Adipocytes were observed focally, while rhabdoid cells were observed multifocally. Immunohistochemically, the tumor showed inconsistent reactivity for desmin but was negative for MYOD1, myogenin, MDM2, and CDK4. Fluorescence in situ hybridization revealed no DDIT3 rearrangement. Despite adjuvant chemotherapy, the tumor metastasized to the thoracic cavity 24 months after excision. The metastatic lesions contained abundant lipoblasts rather than rhabdoid cells, and we concluded this tumor was a MPLS. The presence of rhabdoid cells could be a diagnostic pitfall, and recognizing such a variation in histology would help improve diagnostic accuracy.

    DOI: 10.1177/10668969241226695

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  • Transferrin receptor is associated with sensitivity to ferroptosis inducers in hepatocellular carcinoma. Reviewed International journal

    Hiromatsu M, Toshida K, Itoh S, Harada N, Kohashi K, Oda Y, Yoshizumi T.

    Ann Surg Oncol.   30 ( 13 )   8675 - 8689   2023.12

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    DOI: doi: 10.1245/s10434-023-14053-7.

  • Comparison of radiological and pathological tumor sizes in resected non-small cell lung cancer. Reviewed International journal

    Nagano T, Takamori S, Hashinokuchi A, Matsydo K, Kohno M, Miura N, Takenaka T, Kamitani T, Shimokawa M, Ishigami K, Oda Y, Yoshizumi T.

    Gen Thorac Cardiovasc Surg.   71 ( 12 )   708 - 714   2023.12

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    DOI: doi: 10.1007/s11748-023-01938-3.

  • Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

    Tamura T., Yamasoba D., Oda Y., Ito J., Kamasaki T., Nao N., Hashimoto R., Fujioka Y., Suzuki R., Wang L., Ito H., Kashima Y., Kimura I., Kishimoto M., Tsuda M., Sawa H., Yoshimatsu K., Yamamoto Y., Nagamoto T., Kanamune J., Suzuki Y., Ohba Y., Suzuki S., Kato M., Ferdous Z., Mouri H., Shishido K., Misawa N., Uriu K., Kosugi Y., Fujita S., Suganami M., Chiba M., Yoshimura R., Nakagawa S., Wu J., Takaori-Kondo A., Shirakawa K., Nagata K., Kazuma Y., Nomura R., Horisawa Y., Tashiro Y., Kawai Y., Hashiguchi T., Suzuki T., Kimura K., Sasaki J., Nakajima Y., Sakamoto A., Yasuhara N., Irie T., Kawabata R., Ikeda T., Nasser H., Shimizu R., Begum M., Takahashi O., Ichihara K., Ueno T., Motozono C., Toyoda M., Saito A., Tanaka Y.L., Butlertanaka E.P., Shofa M., Tabata K., Yokota I., Matsuno K., Takayama K., Tanaka S., Sato K., Fukuhara T.

    Communications Biology   6 ( 1 )   2023.12

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    The unremitting emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates ongoing control measures. Given its rapid spread, the new Omicron subvariant BA.5 requires urgent characterization. Here, we comprehensively analyzed BA.5 with the other Omicron variants BA.1, BA.2, and ancestral B.1.1. Although in vitro growth kinetics of BA.5 was comparable among the Omicron subvariants, BA.5 was much more fusogenic than BA.1 and BA.2. Airway-on-a-chip analysis showed that, among Omicron subvariants, BA.5 had enhanced ability to disrupt the respiratory epithelial and endothelial barriers. Furthermore, in our hamster model, in vivo pathogenicity of BA.5 was slightly higher than that of the other Omicron variants and less than that of ancestral B.1.1. Notably, BA.5 gains efficient virus spread compared with BA.1 and BA.2, leading to prompt immune responses. Our findings suggest that BA.5 has low pathogenicity compared with the ancestral strain but enhanced virus spread /inflammation compared with earlier Omicron subvariants.

    DOI: 10.1038/s42003-023-05081-w

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  • Successful Treatment against Mediastinal Methicillin-resistant <i>Staphylococcus aureus</i> Infection after an Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Procedure

    Jo Akihiro, Ikegame Satoshi, Kiyozawa Daisuke, Yoneshima Yasuto, Oda Yoshinao, Okamoto Isamu

    Respiratory Endoscopy   1 ( 2 )   78 - 82   2023.11   eISSN:27583813

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    <p>The case involves a 57-year-old man with a history of laryngeal and lung cancers. He underwent a laryngectomy and right upper lobectomy and developed tracheal methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) colonization. He also underwent endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to diagnose right mediastinal lymph node adenopathy. His recovery was complicated by a mediastinal infection caused by MRSA five days post-procedure. Combining triple antibiotics comprising MEPM, DAP, and VCM for three weeks gradually improved the mediastinal infection. To our knowledge, this is the first report of mediastinal infection caused by MRSA after EBUS-TBNA. Our successful treatment of EBUS-TBNA-related infectious complications gives us information regarding rare complications management caused by EBUS-TBNA.</p>

    DOI: 10.58585/respend.2023-0007

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  • Preferential B cell differentiation by combined immune checkpoint blockade for renal cell carcinoma is associated with clinical response and autoimmune reactions. Reviewed International journal

    Uehara K, Tanoue K, Yamaguchi K, Ohmura H, Ito M, Matsushita Y, Tsuchihashi K, Tamura S, Shimokawa H, Isobe T, Shibata Y, Ariyama H, Tanaka R, Kusaba H, Yamamoto H, Oda Y, Akashi K, Baba E.

    Cancer Immunol Immunother.   72 ( 11 )   3543 - 3558   2023.11

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    DOI: doi: 10.1007/s00262-023-03505-4.

  • Homologous recombination repair gene alterations are associated with tumor mutational burden and survival of immunotherapy. Reviewed International journal

    Ito M, Kubo M, Kawaji H, Otsubo Y, Kurata K, Abutani H, Suyama M, Oda Y, Yoshizumi T, Nakamura M, Baba E.

    Cancers (Basel).   15 ( 23 )   5608   2023.11

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    DOI: doi: 10.3390/cancers15235608.

  • Granzyme B (GZMB)-positive tumor-infiltrating lymphocytes in lung adenocarcinoma: significance as a prognostic factor and association with immunosuppressive proteins. Reviewed International journal

    Kinoshita F, Takada K, Wakasu S, Saito S, Hashinokuchi A, Matsudo K, Nagano T, Akamine T, Kohno M, Takenaka T, Shimokawa M, Oda Y, Yoshizumi T.

    Ann Surg Oncol.   30 ( 12 )   7579 - 7589   2023.11

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    DOI: doi: 10.1245/s10434-023-14085-z.

  • MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma. Reviewed International journal

    Nakanishi T, Yoneshima Y, Okamura K, Yanagihara T, Hashisako M, Iwasaki T, Haratake N, Mizusaki S, Ota K, Iwama E, Takenaka T, Tanaka K, Yoshizumi T, Oda Y, Okamoto I.

    Cancer Sci.   114 ( 10 )   4101 - 4113   2023.10

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    DOI: doi: 10.1111/cas.15921.

  • Survival outcomes including salvage therapy of adult head and neck para-meningeal rhabdomyosarcoma: a multicenter retrospective study from Japan. Reviewed International journal

    BMC Cancer.   23 ( 1 )   1046   2023.10

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    DOI: doi: 10.1186/s12885-023-11528-4.

  • Tertiary lymphoid structures correlate with enhancement of antitumor immunity in esophageal squamous cell carcinoma. Reviewed International journal

    Nakamura S, Ohuchida K, Hayashi M, Katayama N, Tsutsumi C, Yamada Y, Hisano K, Okuda S, Ohtsubo Y, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Nakata K, Moriyama T, Morisaki T, Oda Y, Nakamura M.

    Br J Cancer.   129 ( 8 )   1314 - 1326   2023.10

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    DOI: doi: 10.1038/s41416-023-02396-7

  • Nonmass-forming type anorectal cancer with pagetoid spread: A report of two cases

    Yamamoto, M; Mizuuchi, Y; Tamura, K; Sada, M; Nagayoshi, K; Nakata, K; Ohuchida, K; Oda, Y; Nakamura, M

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   16 ( 4 )   747 - 752   2023.10   ISSN:1758-5902 eISSN:1758-5910

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    Pagetoid spread (PS) of anorectal cancer is relatively rare and associated with poor prognosis. While a primary tumorous lesion is usually obvious in most PS cases, we experienced two cases of nonmass-forming type anorectal cancer with PS. It remains challenging to decide strategies. In both cases, histological findings of a perianal skin biopsy showed proliferation of atypical cells that were positive for cytokeratin (CK) 7, CK20, and caudal type homeobox 2 and negative for Gross cystic disease fluid protein 15, suggesting PS. Abdominoperineal resection (APR) with extensive anal skin resection was performed in both patients. The pathological diagnosis in each was nonmass-forming type anorectal cancer with PS. Neither has experienced recurrence in postoperative courses. Even nonmass-forming type anorectal cancer with PS could have high malignant potentials. APR with lymph nodes dissection and wide skin excision and regular surveillance might be necessary.

    DOI: 10.1111/ases.13217

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  • Lynch症候群による遠位十二指腸腺癌に対してペムブロリズマブによる免疫療法後に病理学的完全奏効を達成した症例 症例報告(A pathological complete response after immunotherapy with pembrolizumab for distal duodenal adenocarcinoma caused by Lynch syndrome: a case report)

    Ikeda Shinichiro, Hu Qingjiang, Natsugoe Keita, Harima Tomoya, Tanaka Yasushi, Kinoshita Izumi, Nonaka Kentaro, Nambara Sho, Nakanishi Ryota, Nakanoko Tomonori, Ota Mitsuhiko, Kimura Yasue, Oki Eiji, Oda Yoshinao, Yoshizumi Tomoharu

    International Cancer Conference Journal   12 ( 4 )   279 - 284   2023.10

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    症例は55歳女性。腹痛を主訴に受診し、上部消化管内視鏡検査で十二指腸第3部にBorrmann 2型腫瘍が認められ、生検により高頻度マイクロサテライト不安定性(MSI-H)と高分化型から中分化型の腺癌が明らかになった。上部消化管造影とCTでも十二指腸に腫瘍が認められ、ステージIV十二指腸腺癌と診断した。腫瘍は左腎静脈に近接しており、小腸の腸間膜リンパ節転移も認められたため、ペムブロリズマブによる術前治療を開始した。2コース終了後に十二指腸狭窄のため緊急入院となり、上部消化管内視鏡検査で十二指腸内腔に微小な穴が認められた。CTでは、腫瘍の著しい退縮と十二指腸狭窄が認められた。リンパ節も著明に縮小していたことから、根治切除が可能であると判断し、腹腔鏡下十二指腸部分切除術とリンパ節郭清を行った。術後経過は順調で、病理学的完全奏効を達成した。生検でMSI-Hが検出されたこと、子宮癌の既往があること、近親者に癌の既往があることから、Lynch症候群(LS)が疑われた。患者の末梢血を用いて遺伝子検査を行ったところ、MSH2遺伝子のNM_000251.3:c.211+1G>Cに変異が認められ、LSと診断した。

  • Guidelines for Handling of Cytological Specimens in Cancer Genomic Medicine

    Morii, E; Hatanaka, Y; Motoi, N; Kawahara, A; Hamakawa, S; Kuwata, T; Nagatomo, T; Oda, Y; Okamoto, A; Tanaka, R; Iyoda, A; Ichiro, M; Matsuo, Y; Nakamura, N; Nakai, T; Fukuhara, M; Tokita, K; Yamaguchi, T; Takenaka, M; Kawabata, A; Hatanaka, KC; Tsubame, K; Satoh, Y

    PATHOBIOLOGY   90 ( 5 )   289 - 311   2023.10   ISSN:1015-2008 eISSN:1423-0291

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    Rapid advances are being made in cancer drug therapy. Since molecularly targeted therapy has been introduced, personalized medicine is being practiced, pathological tissue from malignant tumors obtained during routine practice is frequently used for genomic testing. Whereas cytological specimens fixed mainly in alcohol are considered to be more advantageous in terms of preservation of the nucleic acid quality and quantity. This article is aimed to share the information for the proper handling of cytological specimens in practice for genomic medicine based on the findings established in "Guidelines for Handling of Cytological Specimens in Cancer Genomic Medicine (in Japanese)"published by the Japanese Society of Clinical Cytology in 2021. The three-part practical guidelines are based on empirical data analyses; Part 1 describes general remarks on the use of cytological specimens in cancer genomic medicine, then Part 2 describes proper handling of cytological specimens, and Part 3 describes the empirical data related to handling of cytological specimens. The guidelines indicated proper handling of specimens in each fixation, preparation, and evaluation.

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  • HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and Oropharynx With Multisite Involvement. Reviewed International journal

    Kuga R, Yamamoto H, Jiromaru R, Hongo T, Yasumatsu R, Matsuo M, Hashimoto K, Taniguchi M, Nakagawa T, Oda Y.

    Am J Surg Pathol.   47 ( 9 )   955 - 966   2023.9

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    DOI: doi: 10.1097/PAS.0000000000002086.

  • Upregulated Fcrl5 disrupts B cell anergy causes autoimmune disease. Reviewed International journal

    Ono C, Tanaka S, Myouzen K, Iwasaki T, Ueda M, Oda Y, Yamamoto K, Kochi Y, Baba Y.

    Front Immunol.   14   1276014   2023.9

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    DOI: doi: 10.3389/fimmu.2023.1276014.

  • Granzyme B Expression in the Tumor Microenvironment as a Prognostic Biomarker for Patients with Triple-Negative Breast Cancer. Reviewed International journal

    Mizoguchi K, Kawaji H, Kai M, Morisaki T, Hayashi S, Takao Y, Yamada M, Shimazaki A, Osako T, Arima N, Okido M, Oda Y, Nakamura M, Kubo M.

    Cancers (Basel).   15 ( 18 )   4456   2023.9

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    DOI: doi: 10.3390/cancers15184456.

  • Klotho overexpression is frequently associated with upstream rearrangements in fusion-negative phosphaturic mesenchymal tumors of bone and sinonasal tract. Reviewed International journal

    Lee JC, Hsieh TH, Kao YC, Tsai CF, Huang HY, Shih CY, Song HL, Oda Y, Chen PC, Pan CC, Sittampalam K, Petersson F, Konishi E, Chiu WY, Chen CF, Carpenter TO, Lu TP, Chang CD, Huang SC, Folpe AL.

    Mod Pathol.   36 ( 12 )   100336   2023.9

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    DOI: doi: 10.1016/j.modpat.2023.100336

  • Intratumor Fusobacterium nucleatum promotes the progression of pancreatic cancer via the CXCL1-CXCR2 axis. Reviewed International journal

    Hayashi M, Ikenaga N, Nakata K, Luo H, Zhong P, Date S, Oyama K, Higashijima N, Kubo A, Iwamoto C, Torata N, Abe T, Yamada Y, Ohuchida K, Oda Y, Nakamura M.

    Cancer Sci.   114 ( 9 )   3666 - 3678   2023.9

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    DOI: doi: 10.1111/cas.15901.

  • High-grade serous carcinoma can show squamoid morphology mimicking true squamous differentiation. Reviewed International journal

    Tomonobe H, Ohishi Y, Hachisuga K, Yahata H, Kato K, Oda Y.

    Am J Surg Pathol.   47 ( 9 )   967 - 976   2023.9

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    DOI: doi: 10.1097/PAS.0000000000002089.

  • Intratumor <i>Fusobacterium nucleatum</i> promotes the progression of pancreatic cancer via the CXCL1-CXCR2 axis

    Hayashi, M; Ikenaga, N; Nakata, K; Luo, HZ; Zhong, PS; Date, S; Oyama, K; Higashijima, N; Kubo, A; Iwamoto, C; Torata, N; Abe, T; Yamada, Y; Ohuchida, K; Oda, Y; Nakamura, M

    CANCER SCIENCE   114 ( 9 )   3666 - 3678   2023.9   ISSN:1347-9032 eISSN:1349-7006

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    Intratumor bacteria modify the tumor immune microenvironment and influence outcomes of various tumors. Periodontal pathogen Fusobacterium nucleatum has been detected in pancreatic cancer tissues and is associated with poor prognosis. However, it remains unclear how F. nucleatum affects pancreatic cancer. Here, we compared clinical features with F. nucleatum colonization in pancreatic cancer tissues. F. nucleatum was detected in 15.5% (13/84) of pancreatic cancer patients. The tumor size was significantly larger in the F. nucleatum-positive group than in the negative group. To clarify the biological effect of intratumor F. nucleatum on pancreatic cancer progression, we performed migration/invasion assays and cytokine array analysis of cancer cells cocultured with F. nucleatum. F. nucleatum promoted CXCL1 secretion from pancreatic cancer cells, leading to cancer progression through autocrine signaling. Intratumor F. nucleatum suppressed tumor-infiltrating CD8+ T cells by recruiting myeloid-derived suppressor cells (MDSCs) to the tumor in an F. nucleatum-injected subcutaneous pancreatic cancer mouse model, resulting in tumor progression. Furthermore, tumor growth accelerated by F. nucleatum was suppressed by MDSC depletion or cytokine inhibitors. Intratumor F. nucleatum promoted pancreatic cancer progression through autocrine and paracrine mechanisms of the CXCL1-CXCR2 axis. Blockade of the CXCL1-CXCR2 axis may be a novel therapeutic approach for patients with intratumor F. nucleatum-positive pancreatic cancer.

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  • Modulation of host glutamine anabolism of small cell lung cancer to chemotherapy

    Kodama, M; Toyokawa, G; Sugahara, O; Sugiyama, S; Haratake, N; Yamada, Y; Wada, R; Takamori, S; Shimokawa, M; Takenaka, T; Tagawa, T; Kittaka, H; Tsuruda, T; Tanaka, K; Komatsu, Y; Nakata, K; Imado, Y; Yamazaki, K; Okamoto, I; Oda, Y; Takahashi, M; Izumi, Y; Bamba, T; Shimizu, H; Yoshizumi, T; Nakayama, KI

    CELL REPORTS   42 ( 8 )   112899   2023.8   ISSN:2211-1247

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    Small cell lung cancer (SCLC) is one of the deadliest human cancers, with a 5-year survival rate of ∼7%. Here, we performed a targeted proteomics analysis of human SCLC samples and thereby identified hypoxanthine phosphoribosyltransferase 1 (HPRT1) in the salvage purine synthesis pathway as a factor that contributes to SCLC malignancy by promoting cell survival in a glutamine-starved environment. Inhibition of HPRT1 by 6-mercaptopurine (6-MP) in combination with methotrexate (MTX), which blocks the de novo purine synthesis pathway, attenuated the growth of SCLC in mouse xenograft models. Moreover, modulation of host glutamine anabolism with the glutamine synthetase inhibitor methionine sulfoximine (MSO) in combination with 6-MP and MTX treatment resulted in marked tumor suppression and prolongation of host survival. Our results thus suggest that modulation of host glutamine anabolism combined with simultaneous inhibition of the de novo and salvage purine synthesis pathways may be of therapeutic benefit for SCLC.

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  • Design activities of ECH/CD system for JA DEMO

    Oda Y., Nagasaki K., Fukuyama A., Maekawa T., Idei H., Yanagihara K., Aiba N., Ikeda R., Kajiwara K., Kubo S., Seino T., Tobita K., Uto H., Sakamoto Y.

    AIP Conference Proceedings   2984 ( 1 )   2023.8   ISSN:0094243X

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    JA DEMO is a steady-state tokamak which produces several hundreds of MW of electric power. Electron cyclotron heating and current drive (ECH/CD) system is one of the major components of JA DEMO tokamak, and it is expected to play an important role in its plasma operation scenario. Design activities for JA DEMO ECH/CD are in progress regarding both physics and engineering. Analysis of ECCD physics for current drive efficiency improvement shows that an upper-side injection can produce sufficient driven current by avoiding absorption at second harmonic resonance. RF power for ECCD operation of JA DEMO is expected to be 100 MW at the frequency of >200 GHz range. The conceptual design of the RF power plant represents the location and scale of the building for the RF power plant. The transmission Line (TL) for RF power delivery from the RF power plant to the tokamak exceeds 200 m, and studies of TL components for highly efficient RF transmission are in progress. The concept of the launcher, which combines remote steering technology and phased array, is evaluated by a simulation. A low-power experiment and preliminary results demonstrate that the large oblique angle injection necessary for ECCD operation is possible.

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  • Clinicopathological features and genetic alterations in mixed-type ampullary carcinoma. Reviewed International journal

    Kawata J, Koga Y, Noguchi S, Shimada Y, Yamada Y, Yamamoto T, Shindo K, Nakamura M, Oda Y.

    Mod Pathol.   36 ( 8 )   100181   2023.8

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    DOI: doi: 10.1016/j.modpat.2023.100181.

  • Immune checkpoint status and oncogenic mutation profiling of rectal cancer after neoadjuvant chemotherapy (KSCC1301-A2). Reviewed International journal

    Miyashita Y, Oki E, Kamori T, Akagi Y, Mori S, Hattori N, Kobayashi K, Shimokawa M, Oda Y, Mori M.

    Ann Gastroenterol Surg.   8 ( 2 )   251 - 261   2023.8

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    DOI: doi: 10.1002/ags3.12730

  • Clinical significance of mechanistic target of rapamycin expression in vessels that encapsulate tumor cluster-positive hepatocellular carcinoma patients who have undergone living donor liver transplantation. Reviewed International journal

    Toshida K, Itoh S, Toshima T, Yoshiya S, Goto R, Mita A, Harada N, Kohashi K, Oda Y, Yoshizumi T.

    Ann Gastroenterol Surg.   8 ( 1 )   163 - 171   2023.8

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    DOI: doi: 10.1002/ags3.12735

  • Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy. Reviewed International journal

    Kodama M, Toyokawa G, Sugahara O, Sugiyama S, Haratake N, Yamada Y, Wada R, Takamori S, Shimokawa M, Takenaka T, Tagawa T, Kittaka H, Tsuruda T, Tanaka K, Komatsu Y, Nakata K, Imado Y, Yamazaki K, Okamoto I, Oda Y, Takahashi M, Izumi Y, Bamba T, Shimizu H, Yoshizumi T, Nakayama KI.

    Cell Rep.   42 ( 8 )   112899   2023.8

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    DOI: doi: 10.1016/j.celrep.2023.112899.

  • Evaluation of appropriate conditions for Oncomine DxTT testing of FFPE specimens for driver gene alterations in non-small cell lung cancer. Reviewed International journal

    Iwama E, Yamamoto H, Okubo F, Ijichi K, Ibusuki R, Shiaraishi Y, Yoneshima Y, Tanaka K, Oda Y, Okamoto I.

    Thorac Cancer.   14 ( 23 )   2288 - 2296   2023.8

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    DOI: doi: 10.1111/1759-7714.15014.

  • Involvement of angiogenesis in cancer-associated acinar-to-ductal metaplasia lesion of pancreatic cancer invasive front. Reviewed International journal

    Fei S, Ohuchida K, Kibe S, Yan Z, Iwamoto C, Shinkawa T, Zhang B, Kawata J, Abe T, Ideno N, Ikenaga N, Nakata K, Oda Y, Nakamura M.

    J Cancer Res Clin Oncol.   149 ( 9 )   5885 - 5899   2023.8

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    DOI: doi: 10.1007/s00432-022-04554-5.

  • Diagnostic utility of ERG immunostaining in dermatofibroma. Invited Reviewed International journal

    J Clin Pathol.   76 ( 8 )   536 - 540   2023.8

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    DOI: doi: 10.1136/jclinpath-2022-208158.

  • Clinical significance of the expression of FOXP3 and TIGIT in Merkel cell carcinoma. Reviewed International journal

    Iwasaki T, Hayashi K, Matsushita M, Nonaka D, Matsumoto T, Taniguchi M, Kuwamoto S, Umekita Y, Oda Y.

    Sci Rep.   13 ( 1 )   13114   2023.8

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    DOI: doi: 10.1038/s41598-023-40050-7.

  • Preoperative HALP score is a prognostic factor for intrahepatic cholangiocarcinoma patients undergoing curative hepatic resection: association with sarcopenia and immune microenvironment. Reviewed International journal

    Toshida K, Itoh S, Nakayama Y, Tsutsui Y, Kosai-Fujimoto Y, Tomino T, Yoshiya S, Nagao Y, Harada N, Kohashi K, Oda Y, Yoshizumi T.

    Int J Clin Oncol.   28 ( 8 )   1082 - 1091   2023.8

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    DOI: doi: 10.1007/s10147-023-02358-2.

  • Clinical association between intraoperative indocyanine green fluorescence imaging pattern, preoperative Gd-EOB-DTPA-enhanced magnetic resonance imaging findings, and histological differentiation in hepatocellular carcinoma. Reviewed International journal

    Tomino T, Itoh S, Fujita N, Okamoto D, Nakayama Y, Toshida K, Tomiyama T, Tsutsui Y, Kosai Y, Kurihara T, Nagao Y, Morita K, Harada N, Ushijima Y, Kohashi K, Ishigami K, Oda Y, Yoshizumi T.

    Hepatol Res.   53 ( 8 )   723 - 736   2023.8

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    DOI: doi: 10.1111/hepr.13902.

  • Clinicopathologic Features and Genetic Alterations in Mixed-Type Ampullary Carcinoma

    Kawata, J; Koga, Y; Noguchi, S; Shimada, Y; Yamada, Y; Yamamoto, T; Shindo, K; Nakamura, M; Oda, Y

    MODERN PATHOLOGY   36 ( 8 )   100181   2023.8   ISSN:0893-3952 eISSN:1530-0285

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    Mixed-type ampullary carcinoma is a subtype that combines intestinal-type (I-type) and pancreatobiliary-type (PB-type) lesions, but few studies have examined its clinicopathologic features and genetic alterations. The differences in genetic alterations between mixed type and other subtypes, as well as the genetic differences between I-type and PB-type lesions in the mixed type, remain unclear. In this study, we compared the clinicopathologic features and prognosis of 110 ampullary carcinomas classified by hematoxylin and eosin and immunohistochemical staining as follows: 63 PB-type, 35 I-type, and 12 mixed-type carcinomas. A comparative analysis of genetic mutations by targeted sequencing of 24 genes was also performed in 3 I-type cases, 9 PB-type cases, and I and PB-type lesions of 6 mixed-type cases. The mixed subtype had a poorer prognosis than the other subtypes, and there was also a similar tendency in the adjuvant group (n = 22). A total of 49 genetic mutations were detected in all 18 lesions for which genetic alteration was analyzed. No genetic mutations specific to the mixed type were found, and it was not possible to determine genetically whether the mixed type had originally been I or PB type. However, 5 of 6 cases had mutations common to both I and PB-type lesions, and additional mutations were found only in either I or PB-type lesions. In support of this, the mixed type more frequently exhibited genetic heterogeneity intratumorally than the other subtypes. Mixed-type tumors are histologically, immunohistochemically, and genetically heterogeneous, and this heterogeneity is associated with poor prognosis and may affect treatment resistance.

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  • Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics

    Thaler, R; Yoshizaki, K; Nguyen, T; Fukumoto, S; Den Besten, P; Bikle, DD; Oda, Y

    COMMUNICATIONS BIOLOGY   6 ( 1 )   766   2023.7   eISSN:2399-3642

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    Postnatal cell fate is postulated to be primarily determined by the local tissue microenvironment. Here, we find that Mediator 1 (Med1) dependent epigenetic mechanisms dictate tissue-specific lineage commitment and progression of dental epithelia. Deletion of Med1, a key component of the Mediator complex linking enhancer activities to gene transcription, provokes a tissue extrinsic lineage shift, causing hair generation in incisors. Med1 deficiency gives rise to unusual hair growth via primitive cellular aggregates. Mechanistically, we find that MED1 establishes super-enhancers that control enamel lineage transcription factors in dental stem cells and their progenies. However, Med1 deficiency reshapes the enhancer landscape and causes a switch from the dental transcriptional program towards hair and epidermis on incisors in vivo, and in dental epithelial stem cells in vitro. Med1 loss also provokes an increase in the number and size of enhancers. Interestingly, control dental epithelia already exhibit enhancers for hair and epidermal key transcription factors; these transform into super-enhancers upon Med1 loss suggesting that these epigenetic mechanisms cause the shift towards epidermal and hair lineages. Thus, we propose a role for Med1 in safeguarding lineage specific enhancers, highlight the central role of enhancer accessibility in lineage reprogramming and provide insights into ectodermal regeneration.

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  • The Factors Associated with the Selection of Early Excision Surgery for Congenital Biliary Dilatation with a Prenatal Diagnosis. Reviewed International journal

    Shirai T, Matsuura T, Tamaki A, Kajihara K, Uchida Y, Kawano Y, Toriigahara Y, Obata S, Kawakubo N, Yoshimaru K, Yanagi Y, Nagata K, Kohashi K, Oda Y, Tajiri T.

    J Pediatr Surg.   58 ( 7 )   1246 - 1251   2023.7

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    DOI: doi: 10.1016/j.jpedsurg.2023.01.050.

  • 胆管癌に対する胆汁、胆管擦過細胞診の診断精度に関する後方視的検討 Reviewed

    並河真美、大久保文彦、山口知彦、野上美和子、山本猛雄、岩崎健、藤森尚、仲田興平、中村雅史、小田義直

    日本臨床細胞学会九州連合会雑誌   54   39 - 44   2023.7

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  • Histological and immunohistochemical prognostic factors of primary angiosarcoma. Reviewed International journal

    Ichiki T, Yamada Y, Ito T, Nakahara T, Nakashima Y, Nakamura M, Yoshizumi T, Shiose A, Akashi K, Oda Y.

    Virchows Arch.   483 ( 1 )   59 - 69   2023.7

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    DOI: doi: 10.1007/s00428-023-03572-z.

  • Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma. Reviewed International journal

    Ishihara S, Iwasaki T, Kohashi K, Kawaguchi K, Toda Y, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Oda Y.

    J Cancer Res Clin Oncol.   149 ( 6 )   2425 - 2436   2023.6

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    DOI: doi: 10.1007/s00432-022-04078-y.

  • MAML3 contributes to induction of malignant phenotype of gallbladder cancer through morphogenesis signalling under hypoxia. Reviewed International journal

    Anticancer Res.   43 ( 7 )   2909 - 2922   2023.6

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    DOI: doi: 10.21873/anticanres.16462.

  • Prognostic impact of noninvasive areas in resected pathological stage IA lung adenocarcinoma. Reviewed International journal

    Kinoshita F, Shimokawa M, Takenaka T, Okamoto T, Taguchi K, Oda Y, Yoshizumi T.

    Thorac Cancer.   14 ( 18 )   1651 - 1569   2023.6

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    DOI: doi: 10.1111/1759-7714.14910.

  • Clinical significance of signal regulatory protein alpha (SIRPα) expression in hepatocellular carcinoma. Reviewed International journal

    Tomiyama T, Itoh S, Iseda N, Toshida K, Kosai-Fujimoto Y, Tomino T, Kurihara T, Nagao Y, Morita K, Harada N, Liu YC, Ozaki D, Kohashi K, Oda Y, Mori M, Yoshizumi T.

    Ann Surg Oncol.   30 ( 6 )   3378 - 3389   2023.6

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    DOI: 10.1245/s10434-022-13058-y.

  • Preventive effect of tertiary lymphoid structures on lymph node metastasis of lung adenocarcinoma. Reviewed International journal

    Wakasu S, Tagawa T, Haratake N, Kinoshita F, Oku Y, Ono Y, Takenaka T, Oda Y, Shimokawa M, Mori M.

    Cancer Immunol Immunother.   72 ( 6 )   1823 - 1834   2023.6

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    DOI: doi: 10.1007/s00262-022-03353-8.

  • Artificial intelligence-based prediction of recurrence after curative resection for colorectal cancer from digital pathological images. Reviewed International journal

    Nakanishi R, Morooka K, Omori K, Toyota S, Tanaka Y, Hasuda H, Koga N, Nonaka K, Hu Q, Nakaji Y, Nakanoko T, Ando K, Ota M, Kimura Y, Oki E, Oda Y, Yoshizumi T.

    Ann Surg Oncol.   2023.6

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    DOI: doi: 10.1245/s10434-022-12926-x.

  • Artificial Intelligence-Based Prediction of Recurrence After Curative Resection for Colorectal Cancer From a Digital Pathologic Image

    Nakanishi, R; Morooka, K; Omori, K; Toyota, S; Tanaka, Y; Hasuda, H; Koga, N; Nonaka, K; Hu, QJ; Nakaji, Y; Nakanoko, T; Ando, K; Ota, M; Kimura, Y; Oki, E; Oda, Y; Yoshizumi, T

    ANNALS OF SURGICAL ONCOLOGY   30 ( 6 )   3515 - 3516   2023.6   ISSN:1068-9265 eISSN:1534-4681

  • Prognostic implications of the immunohistochemical expression of perilipin 1 and adipophilin in high-grade liposarcoma

    77 ( 10 )   676 - 682   2023.5   ISSN:0021-9746 eISSN:1472-4146

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  • Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

    Tamura, T; Ito, J; Uriu, K; Zahradnik, J; Kida, I; Anraku, Y; Nasser, H; Shofa, M; Oda, Y; Lytras, S; Nao, N; Itakura, Y; Deguchi, S; Suzuki, R; Wang, L; Begum, MMST; Kita, S; Yajima, H; Sasaki, J; Sasaki-Tabata, K; Shimizu, R; Tsuda, M; Kosugi, Y; Fujita, S; Pan, L; Sauter, D; Yoshimatsu, K; Suzuki, S; Asakura, H; Nagashima, M; Sadamasu, K; Yoshimura, K; Yamamoto, Y; Nagamoto, T; Schreiber, G; Maenaka, K; Hashiguchi, T; Ikeda, T; Fukuhara, T; Saito, A; Tanaka, S; Matsuno, K; Takayama, K; Sato, K

    NATURE COMMUNICATIONS   14 ( 1 )   2800   2023.5   eISSN:2041-1723

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    In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions.

    DOI: 10.1038/s41467-023-38435-3

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  • Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

    Ito, J; Suzuki, R; Uriu, K; Itakura, Y; Zahradnik, J; Kimura, KT; Deguchi, S; Wang, L; Lytras, S; Tamura, T; Kida, I; Nasser, H; Shofa, M; Begum, MM; Tsuda, M; Oda, Y; Suzuki, T; Sasaki, J; Sasaki-Tabata, K; Fujita, S; Yoshimatsu, K; Ito, H; Nao, N; Asakura, H; Nagashima, M; Sadamasu, K; Yoshimura, K; Yamamoto, Y; Nagamoto, T; Kuramochi, J; Schreiber, G; Saito, A; Matsuno, K; Takayama, K; Hashiguchi, T; Tanaka, S; Fukuhara, T; Ikeda, T; Sato, K; Suzuki, S; Kato, M; Ferdous, Z; Mouri, H; Shishido, K; Misawa, N; Kimura, I; Kosugi, Y; Lin, P; Suganami, M; Chiba, M; Yoshimura, R; Yasuda, K; Iida, K; Ohsumi, N; Strange, AP; Sauter, D; Nakagawa, S; Wu, JQ; Watanabe, Y; Sakamoto, A; Yasuhara, N; Nakajima, Y; Yajima, H; Shirakawa, K; Takaori-Kondo, A; Nagata, K; Kazuma, Y; Nomura, R; Horisawa, Y; Tashiro, Y; Kawa, Y; Irie, T; Kawabata, R; Shimizu, R; Takahashi, O; Ichihara, K; Motozono, C; Toyoda, M; Ueno, T; Shibatani, Y; Nishiuchi, T

    NATURE COMMUNICATIONS   14 ( 1 )   2671   2023.5   eISSN:2041-1723

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    In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These variants convergently acquired amino acid substitutions at critical residues in the spike protein, including residues R346, K444, L452, N460, and F486. Here, we characterize the convergent evolution of Omicron subvariants and the properties of one recent lineage of concern, BQ.1.1. Our phylogenetic analysis suggests that these five substitutions are recurrently acquired, particularly in younger Omicron lineages. Epidemic dynamics modelling suggests that the five substitutions increase viral fitness, and a large proportion of the fitness variation within Omicron lineages can be explained by these substitutions. Compared to BA.5, BQ.1.1 evades breakthrough BA.2 and BA.5 infection sera more efficiently, as demonstrated by neutralization assays. The pathogenicity of BQ.1.1 in hamsters is lower than that of BA.5. Our multiscale investigations illuminate the evolutionary rules governing the convergent evolution for known Omicron lineages as of 2022.

    DOI: 10.1038/s41467-023-38188-z

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  • Prognostic value of nuclear morphometry in myxoid liposarcoma. Reviewed International journal

    Kawaguchi K, Kohashi K, Iwasaki T, Yamamoto T, Ishihara S, Toda Y, Yamamoto H, Nakashima Y, Oda Y.

    Cancer Sci.   114 ( 5 )   2178 - 2188   2023.5

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    DOI: doi: 10.1111/cas.15729.

  • Prognostic implications of the immunohistochemical expression of perilipin 1 and adipophilin in high-grade liposarcoma. Reviewed International journal

    Kawaguchi K, Kohashi K, Mori T, Yamamoto H, Iwasaki T, Kinoshita I, Susuki Y, Furukawa H, Endo M, Matsumoto Y, Nakashima Y, Oda Y.

    (Online ahead of print.) J Clin Pathol.   2023.5

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    DOI: doi: 10.1136/jcp-2023-208814.

  • Prognostic significance for recurrence of FGFR2 in intrahepatic cholangiocarcinoma patients undergoing curative hepatic resection. Reviewed International journal

    Hepatol Res.   53 ( 5 )   432 - 439   2023.5

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    DOI: doi: 10.1111/hepr.13875.

  • Extracellular volume fraction determined by dual-layer spectral detector CT: Possible role in predicting the efficacy of preoperative neoadjuvant chemotherapy in pancreatic ductal adenocarcinoma. Reviewed International journal

    Fujita N, Ushijima Y, Itoyama M, Okamoto D, Ishimatsu K, Wada N, Takao S, Murayama R, Fujimori N, Nakata K, Nakamura M, Yamamoto T, Oda Y, Ishigami K.

    Eur J Radiol.   162   110756   2023.5

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    DOI: doi: 10.1016/j.ejrad.2023.110756.

  • Prognostic significance for recurrence of fibroblast growth factor receptor 2 in intrahepatic cholangiocarcinoma patients undergoing curative hepatic resection

    Toshida, K; Itoh, S; Yugawa, K; Kosai, Y; Tomino, T; Yoshiya, S; Nagao, Y; Kayashima, H; Harada, N; Kohashi, K; Oda, Y; Yoshizumi, T

    HEPATOLOGY RESEARCH   53 ( 5 )   432 - 439   2023.5   ISSN:1386-6346 eISSN:1872-034X

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    Aims: The fibroblast growth factor receptor 2 (FGFR2) fusion gene is frequently found as a genetic abnormality in the FGFR pathway in patients with intrahepatic cholangiocarcinoma (ICC). The FGFR fusion protein, produced from the FGFR fusion gene, is thought to cause tumor cell growth. To date, there have been few reports on the relationship between pathologic FGFR2 expression and prognosis in patients who have undergone hepatectomy for ICC, and on the relationship between FGFR2 and tumor-infiltrating lymphocytes (TILs). Methods and Results: We enrolled 92 patients who underwent hepatectomy for ICC and performed immunohistochemical staining for FGFR2 and cluster of differentiation 8, and hematoxylin and eosin staining for evaluating TILSs. The relationships between the FGFR2 and clinicopathological characteristics and outcomes were analyzed, and patients were classified into positive (n = 18) and negative (n = 74) FGFR2 groups. The FGFR2-positive group contained more men (p < 0.0001) and had lower serum albumin (p = 0.0355) and higher carcinoembryonic antigen (p = 0.0099). Furthermore, multivariable analyses revealed that the FGFR2-positive group had worse disease-free survival (DFS) (p = 0.0002). Multivariate analysis showed that the independent prognostic factors for DFS were maximum tumor size (≥5 cm) (p = 0.0011), tumor localization (perihilar type) (p = 0.0180), and FGFR2 positivity (p = 0.0029). There was no significant difference in TILs count between the two groups. Conclusion: We showed that FGFR2 high expression was an independent prognostic factor for recurrence of resected ICC.

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  • Comparison of Akt/mammalian target of rapamycin/4E-binding protein 1 pathway signal activation in round stromal and surface cells in patients with sclerosing pneumocytoma. Reviewed International journal

    Hashisako M, Iwasaki T, Matsumoto T, Yamada Y, Miyamoto T, Taniguchi M, Oishi C, Oda Y.

    Pathol Res Pract.   244   154384   2023.4

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    DOI: doi: 10.1016/j.prp.2023.154384.

  • Ampullary neuroendocrine neoplasm: clinicopathological characteristics and novel endoscopic entity. Invited Reviewed International journal

    Matsumoto K, Fujimori N, Hata Y, Minoda Y, Murakami M, Teramatsu K, Takamatsu Y, Takeno A, Oono T, Ihara E, Nakata K, Nakamura M, Yamamoto T, Koga Y, Oda Y, Ito T, Ogawa Y.

    Dig Dis.   41 ( 2 )   316 - 324   2023.4

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    DOI: doi: 10.1159/000525013.

  • Correlation between extended pelvic lymph node dissection and urinary incontinence at early phase after robot-assisted radical prostatectomy. Reviewed International journal

    Lee K, Shiota M, Takamatsu D, Ushijima M, Blas L, Okabe A, Kajioka S, Goto S, Kinoshita F, Matsumoto T, Monji K, Kashiwagi E, Inokuchi J, Oda Y, Eto M.

    Int J Urol.   30 ( 4 )   340 - 346   2023.4

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    DOI: doi: 10.1111/iju.15119.

  • Prognostic impact of CD73/adenosine 2A receptor (A2AR) in renal cell carcinoma and immune microenvironmental status with sarcomatoid changes and rhabdoid features. Reviewed International journal

    Takamatsu D, Kiyozawa D, Kohashi K, Kinoshita F, Toda Y, Ishihara S, Eto M, Oda Y.

    Pathol Res Pract.   244   154423   2023.4

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    DOI: doi: 10.1016/j.prp.2023.154423.

  • Pancreatoblastoma with a novel fusion gene of <i>IQSEC1-RAF1</i>

    Goto, H; Koga, Y; Kohashi, K; Ono, H; Takemoto, J; Matsuura, T; Tajiri, T; Ihara, K; Oda, Y; Ohga, S

    PEDIATRIC BLOOD & CANCER   70 ( 4 )   e30155   2023.4   ISSN:1545-5009 eISSN:1545-5017

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    DOI: 10.1002/pbc.30155

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  • Interstitial pneumonia after regression by olaparib for neuroendocrine prostate cancer with <i>BRCA1</i> mutation: a case report

    Kaitsumaru, M; Shiota, M; Takamatsu, D; Blas, L; Matsumoto, T; Inokuchi, J; Oda, Y; Eto, M

    INTERNATIONAL CANCER CONFERENCE JOURNAL   12 ( 2 )   131 - 136   2023.4   ISSN:2192-3183

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  • Heidenhain Variant of Sporadic Creutzfeldt-Jakob Disease with a Variety of Visual Symptoms: A Case Report with Autopsy Study

    Hisata, Y; Yamashita, S; Tago, M; Yoshimura, M; Nakasima, T; Nishi, TM; Oda, Y; Honda, H; Yamashita, SI

    AMERICAN JOURNAL OF CASE REPORTS   24   e938654   2023.3   eISSN:1941-5923

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    Objective: Background: Case Report: Conclusions: Rare disease Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal disease caused by the change of prion protein (PrP). Affected patients present with rapidly progressive cognitive dysfunction, myoclonus, or akinetic mutism. Diagnosing the Heidenhain variant of sCJD, which initially causes various visual symptoms, can be particularly difficult. A 72-year-old woman presented with a 2-to 3-month history of photophobia, blurring vision in both eyes. Seven days previously, she showed visual impairment of 20/2000 in both eyes. Left homonymous hemianopia and restricted downward movement of the left eye were observed with an intact pupillary light reflex and normal fundoscopy. On admission, her visual acuity was light perception. Cranial magnetic resonance imaging revealed no abnormality, and electroencephalography showed no periodic synchronous discharges. Cerebrospinal fluid examination on the sixth hospital day revealed tau and 14-3-3 protein with a positive result of real-time quak-ing-induced conversion. She thereafter developed myoclonus and akinetic mutism and died. Autopsy revealed thinning and spongiform change of the cerebral cortex of the right occipital lobe. Immunostaining showed syn-aptic-type deposits of abnormal PrP and hypertrophic astrocytes. Consequently, she was diagnosed with the Heidenhain variant of sCJD with both methionine/methionine type 1 and type 2 cortical form based on the western blot of cerebral tissue and PrP gene codon 129 polymorphism. When a patient presents with various progressive visual symptoms, even without typical findings of electro-encephalography or cranial magnetic resonance imaging, it is essential to suspect the Heidenhain variant of sCJD and perform appropriate cerebrospinal fluid tests.

    DOI: 10.12659/AJCR.938654

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  • High-risk HPV-related squamous cell carcinoma in the temporal bone: a rare but noteworthy subtype. Reviewed International journal

    Hongo T, Yamamoto H, Kuga R, Komune N, Miyazaki M, Tsuchihashi NA, Noda T, Matsumoto N, Oda Y, Nakagawa T.

    Virchows Arch.   482 ( 3 )   539 - 550   2023.3

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    DOI: doi: 10.1007/s00428-023-03497-7.

  • Neoadjuvant chemotherapy enhances anti-tumor immune response of tumor microenvironment in human esophageal squamous cell carcinoma. Reviewed International journal

    Okuda S, Ohuchida K, Nakamura S, Tsutsumi C, Hisano K, Mochida Y, Kawata J, Ohtsubo Y, Shinkawa T, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Moriyama T, Nakata K, Torisu T, Morisaki T, Kitazono T, Oda Y, Nakamura M.

    iScience.   26 ( 4 )   4106480   2023.3

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    DOI: doi: 10.1016/j.isci.2023.106480.

  • Cancer-associated fibroblasts promote tumor cell growth via miR-493-5p in intrahepatic cholangiocarcinoma. Reviewed International journal

    Cancer Sci.   114 ( 3 )   937 - 947   2023.3

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    DOI: doi: 10.1111/cas.15644.

  • Protocol for the 2ND-STEP study, Japan Clinical Oncology Group study JCOG1802: a randomized phase II trial of second-line treatment for advanced soft tissue sarcoma comparing trabectedin, eribulin and pazopanib. Reviewed International journal

    Endo M, Kataoka T, Fujiwara T, Tsukushi S, Takahashi M, Kobayashi E, Yamada Y, Tanaka T, Nezu Y, Hiraga H, Wasa J, Nagano A, Nakano K, Nakayama R, Hamada T, Kawano M, Torigoe T, Sakamoto A, Asanuma K, Morii T, Machida R, Sekino Y, Fukuda H, Oda Y, Ozaki T, Tanaka K.

    BMC Cancer.   23 ( 1 )   219   2023.3

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    DOI: doi: 10.1186/s12885-023-10693-w.

  • TFE3-immunopositive papillary renal cell carcinoma: A clinicopathological, immunohistochemical, and genetic study. Reviewed International journal

    Takamatsu D, Kohashi K, Kiyozawa D, Kinoshita F, Ieiri K, Baba M, Eto M, Oda Y.

    Pathol Res Pract.   242   154313   2023.2

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  • Translocation of nuclear chromatin distribution to the periphery reflects dephosphorylated threonine-821/826 of the retinoblastoma protein (pRb) in T24 cells treated with Bacillus Calmette-Guérin. Reviewed International journal

    Uehara T, Watanabe S, Yamaguchi S, Eguchi N, Sakamoto N, Oda Y, Arimura H, Kaku T, Ohishi Y, Mizuno S.

    Cytotechnology.   75 ( 1 )   49 - 62   2023.2

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    DOI: 10.1007/s10616-022-00559-7.

  • Human epidermal growth factor receptor 3 serves as a novel therapeutic target for acral melanoma. Reviewed International journal

    Tanaka Y, Ito T, Kaku-Ito Y, Tanegashima K, Tsuji G, Kido-Nakahara M, Oda Y, Nakahara T.

    Cell Death Discov.   9 ( 1 )   54   2023.2

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    DOI: doi: 10.1038/s41420-023-01358-5.

  • Clinical implications of FDG-PET in pancreatic ductal adenocarcinoma patients treated with neoadjuvant therapy. Reviewed International journal

    Ikenaga N, Nakata K, Hayashi M, Nakamura S, Abe T, Ideno N, Murakami M, Fujimori N, Fujita N, Isoda T, Baba S, Ishigami K, Oda Y, Nakamura M.

    J Gastrointest Surg.   27 ( 2 )   337 - 346   2023.2

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    DOI: doi: 10.1007/s11605-023-05591-2.

  • A newly proposed grading system of nuclear morphology and the molecular genetic background in myxoid liposarcoma

    Kawaguchi, K; Kohashi, K; Ishihara, S; Toda, Y; Iwasaki, T; Yamamoto, T; Endo, M; Matsumoto, Y; Oda, Y

    CANCER SCIENCE   114   266 - 266   2023.2   ISSN:1347-9032 eISSN:1349-7006

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  • Translocation of nuclear chromatin distribution to the periphery reflects dephosphorylated threonine-821/826 of the retinoblastoma protein (pRb) in T24 cells treated with Bacillus Calmette-Guerin

    Uehara, T; Watanabe, S; Yamaguchi, S; Eguchi, N; Sakamoto, N; Oda, Y; Arimura, H; Kaku, T; Ohishi, Y; Mizuno, S

    CYTOTECHNOLOGY   75 ( 1 )   49 - 62   2023.2   ISSN:0920-9069 eISSN:1573-0778

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    The standard treatment for non-muscle-invasive bladder cancer is intravesical Bacillus Calmette–Guérin (BCG) therapy, which is considered the only intravesical therapy that reduces the risk of progression to muscle-invasive cancer. BCG unresponsiveness, in which intravesical BCG therapy is ineffective, has become a problem. It is thus important to evaluate the effectiveness of BCG treatment for patients as soon as possible in order to identify the optimal therapy. Urine cytology is a noninvasive, easy, and cost-effective method that has been used during BCG treatment, but primarily only to determine benign or malignant status; findings concerning the efficacy of BCG treatment based on urine cytology have not been reported. We investigated the relationship between BCG exposure and nuclear an important criterion in urine cytology, i.e., nuclear chromatin patterns. We used three types of cultured cells to evaluate nuclear chromatin patterns and the cell cycle, and we used T24 cells to evaluate the phosphorylation of retinoblastoma protein (pRb) in six-times of BCG exposures. The results revealed that after the second BCG exposure, (i) nuclear chromatin is distributed predominantly at the nuclear periphery and (ii) the dephosphorylation of threonine-821/826 in pRb occurs. This is the first report of a dynamic change in the nuclear chromatin pattern induced by exposure to BCG. Molecular findings also suggested a relationship between this phenomenon and cell-cycle proteins. Although these results are preliminary, they contribute to our understanding of the cytomorphological changes that occur with BCG exposure.

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  • Epitranscriptomic controls in soft-tissue leiomyosarcoma

    Iwasaki, T; Matsumoto, T; Ichiki, T; Kohashi, K; Oda, Y

    CANCER SCIENCE   114   642 - 642   2023.2   ISSN:1347-9032 eISSN:1349-7006

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  • Clinicopathological features and genetic alterations in histological subtypes of ampullary carcinoma

    Kawata, J; Koga, Y; Noguchi, S; Shimada, Y; Yamada, Y; Yamamoto, T; Oda, Y

    CANCER SCIENCE   114   406 - 406   2023.2   ISSN:1347-9032 eISSN:1349-7006

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  • Challenges and Prospects for Establishment of a Central Pathology Network for Rare Cancer Control: Focusing on Sarcomas

    Oda, Y

    CANCER SCIENCE   114   1612 - 1612   2023.2   ISSN:1347-9032 eISSN:1349-7006

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  • Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G plus cancer cells and SPP1+macrophages in colorectal cancer

    Ozato, Y; Kojima, Y; Kobayashi, Y; Hisamatsu, Y; Toshima, T; Yonemura, Y; Masuda, T; Kagawa, K; Goto, Y; Utou, M; Fukunaga, M; Gamachi, A; Imamura, K; Kuze, Y; Zenkoh, J; Suzuki, A; Niida, A; Hirose, H; Hayashi, S; Koseki, J; Oki, E; Fukuchi, S; Murakami, K; Tobo, T; Nagayama, S; Uemura, M; Sakamoto, T; Oshima, M; Doki, Y; Eguchi, H; Mori, M; Iwasaki, T; Oda, Y; Shibata, T; Suzuki, Y; Shimamura, T; Mimori, K

    CELL REPORTS   42 ( 1 )   111929   2023.1   ISSN:2211-1247

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    The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are poorly understood, hindering patient treatment. In the current study, we investigate whether events occurring at the invasion front are of particular importance for CRC treatment strategies. To this end, we analyze CRC tissues by combining spatial transcriptomics from patients with a public single-cell transcriptomic atlas to determine cell-cell interactions at the invasion front. We show that CRC cells are localized specifically at the invasion front. These cells induce human leukocyte antigen G (HLA-G) to produce secreted phosphoprotein 1 (SPP1)+ macrophages while conferring CRC cells with anti-tumor immunity, as well as proliferative and invasive properties. Taken together, these findings highlight the signaling between CRC cell populations and stromal cell populations at the cellular level.

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  • Expression of SATB2, RUNX2, and SOX9 and possible osteoblastic and chondroblastic differentiation in chondroblastoma. Reviewed International journal

    Toda Y, Yamamoto H, Iwasaki T, Ishihara S, Ito Y, Susuki Y, Kawaguchi K, Kinoshita I, Kiyozawa D, Yamada Y, Kohashi K, Kimura A, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Mawatari M, Oda Y.

    Pathol Res Pract.   ( 241 )   154239   2023.1

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    DOI: doi: 10.1016/j.prp.2022.154239.

  • C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions. Reviewed International journal

    Nagao S, Onishi H, Kawamoto M, Masuda S, Na L, Morisaki S, Iwamoto N, Yamada Y, Koga S, Ichimiya S, Nakayama K, Imaizumi A, Nakashima K, Oda Y, Nakamura M.

    J Cancer.   14 ( 2 )   306 - 317   2023.1

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    DOI: doi: 10.7150/jca.78993.

  • The expression of insulin-like growth factor II messenger RNA-binding protein 3 upregulated in intradural extramedullary schwannomas. Reviewed International journal

    Bekki H, Matsumoto Y, Yoshimoto M, Ishihara S, Kawaguchi K, Yamamoto H, Oda Y, Nakashima Y, Harimaya K.

    Spine Surg Relat Res.   7 ( 1 )   36 - 41   2023.1

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    DOI: doi: 10.22603/ssrr.2022-0063.

  • Subcutaneous thyroid tissue implantation after thyroidectomy: a mimic of benign cutaneous tumours. Reviewed International journal

    Takei I, Ito T, Mori T, Oda Y, Nakahara T.

    Acta Derm Venereol.   103   adv00842   2023.1

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    DOI: doi: 10.2340/actadv.v103.4407.

  • Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer. Reviewed International journal

    Ozato Y, Kojima Y, Kobayashi Y, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Kagawa K, Goto Y, Utou M, Fukunaga M, Gamachi A, Imamura K, Kuze Y, Zenkoh J, Suzuki A, Niida A, Hirose H, Hayashi S, Koseki J, Oki E, Fukuchi S, Murakami K, Tobo T, Nagayama S, Uemura M, Sakamoto T, Oshima M, Doki Y, Eguchi H, Mori M, Iwasaki T, Oda Y, Shibata T, Suzuki Y, Shimamura T, Mimori K.

    Cell Rep.   42 ( 1 )   111929   2023.1

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    DOI: doi: 10.1016/j.celrep.2022.111929.

  • Single-cell transcriptome analysis reveals functional changes in tumour-infiltrating B lymphocytes after chemotherapy in oesophageal squamous cell carcinoma. Reviewed International journal

    Nakamura S, Ohuchida K, Ohtsubo Y, Yamada Y, Tsutsumi C, Okuda S, Hisano K, Mochida Y, Shinkawa T, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Nakata K, Moriyama T, Torisu T, Nagai E, Morisaki T, Kitazono T, Oda Y, Nakamura M.

    Clin Transl Med.   13 ( 1 )   e1181   2023.1

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    DOI: doi: 10.1002/ctm2.1181.

  • C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions. Reviewed International journal

    Nagao S, Onishi H, Kawamoto M, Masuda S, Na L, Morisaki S, Iwamoto N, Yamada Y, Koga S, Ichimiya S, Nakayama K, Imaizumi A, Nakashima K, Oda Y, Nakamura M.

    J Cancer.   14 ( 2 )   306 - 317   2023.1

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    DOI: doi: 10.7150/jca.78993.

  • Conformer-Based Lip-Reading for Japanese Sentence

    Arakane T., Saitoh T., Chiba R., Morise M., Oda Y.

    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)   13836 LNCS   474 - 485   2023   ISSN:03029743 ISBN:9783031258244

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    Various applications of lip-reading technology are considered, and it is an important issue. In recent years, lip-reading research on sentences has attracted attention. However, most of the published datasets are English-talking scenes, and there are few datasets other than English. Therefore, in this research, we are researching Japanese sentence-level lip-reading. In this paper, we construct Japanese sentence utterance scene datasets ITA and ROHAN4600 and propose the Conformer-based lip-reading method. Recognition experiments were conducted using the Transformer model as a conventional method. As a result, it was confirmed that the Conformer model obtained high recognition accuracy both at the phoneme and the mora levels.

    DOI: 10.1007/978-3-031-25825-1_34

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  • Analysis of clinicopathological features and NAB2-STAT6 fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle. Reviewed International journal

    Shirakura T, Yamada Y, Nakata S, Asayama B, Seo Y, Tanikawa S, Kato T, Komoribayashi N, Kubo N, Monma N, Okura N, Tanaka S, Oda Y, Hirato J, Yokoo H, Nobusawa S.

    Virchows Arch.   481 ( 6 )   913 - 923   2022.12

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    DOI: doi: 10.1007/s00428-022-03403-7.

  • Immunohistochemistry reveals an increased number of ganglion cells in the normal-size plexus, as a pathological feature of immaturity of ganglia

    Yoshimaru K., Miyoshi K., Kinoshita Y., Obata S., Yanagi Y., Takahashi Y., Kajihara K., Irie K., Uchida Y., Toriigahara Y., Kawano Y., Kohashi K., Yoshioka T., Nakazawa A., Matsuura T., Oda Y., Tajiri T., Taguchi T.

    Comparative Clinical Pathology   31 ( 6 )   951 - 957   2022.12   ISSN:16185641

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    Immaturity of ganglia (IG), is a rare entity of an allied disorder of Hirschsprung’s disease. We reviewed our IG cases to provide further pathological insight into IG. The clinical data and pathological findings of IG cases in our department from 2011 to 2020 were examined. Hematoxylin and eosin (HE) staining and immunostaining for HuC/D, BCL-2, SOX10, and CD56 were performed on full-thickness specimens. Sufficient clinical data and pathological specimens were available in five cases during the study period. The patient profiles were as follows: four term infants and one preterm infant with initial symptoms of abdominal distension or vomiting; all cases underwent ileostomy at a median age of 2 days and stoma closure at a median age of 5 months. Although the interpretation of HE staining was difficult, immunostaining for HuC/D and SOX10 clearly distinguished ganglion cells from glial cells. The number of ganglion cells in the IG group was significantly greater than that in the control group (p < 0.05), while the number of enteric glial cells and total area of the myenteric nerve plexus did not differ. The finding of the increased number of ganglion cells in a normal-size myenteric plexus is a novel feature of IG that contributes to its accurate diagnosis.

    DOI: 10.1007/s00580-022-03390-w

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  • Analysis of clinicopathological features and <i>NAB2</i>-<i>STAT6</i> fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle

    Shirakura, T; Yamada, Y; Nakata, S; Asayama, B; Seo, Y; Tanikawa, S; Kato, T; Komoribayashi, N; Kubo, N; Monma, N; Okura, N; Tanaka, S; Oda, Y; Hirato, J; Yokoo, H; Nobusawa, S

    VIRCHOWS ARCHIV   481 ( 6 )   913 - 923   2022.12   ISSN:0945-6317 eISSN:1432-2307

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    Solitary fibrous tumors (SFTs) are rare mesenchymal tumors that can occur at any location. Since the identification of specific NAB2-STAT6 fusion in SFTs, the fusion gene variants, NAB2 exon 4-STAT6 exon 2/3 and NAB2 exon 5/6/7-STAT6 exon 16/17/18, have been reported to be associated with clinicopathological features, and the latter variant is predominant in meningeal SFTs. SFTs developing in the salivary glands are rare, and more rarely, those involving ectopic salivary glands (ESGs) have been reported in the cerebellopontine angle (CPA); however, their characteristics remain not well understood. In this study, we performed a clinicopathological and molecular analysis of 3 cases of meningeal SFT with ESGs. All cases presented with an extra-axial mass in the CPA, which is a rarer location for intracranial ESGs compared to the sellar region. Histologically, except for the presence of ESGs, there was no significant difference between current cases and ordinary SFTs. The ESGs demonstrated no cellular atypia, and although the spindle tumor cells were immunopositive for STAT6, the ESGs were negative in all cases, supporting that the ESGs are non-neoplastic components. In 1 case, ESGs were found only in the primary tumor and disappeared in recurrence/dissemination. Of note, molecular analysis identified NAB2 exon 4-STAT6 exon 2 in all cases. In conclusion, our results suggest that ESGs particularly in the CPA may be associated with SFTs and that meningeal SFTs with ESGs may be associated with the minor fusion variant of NAB2-STAT6 in the intracranial lesions.

    DOI: 10.1007/s00428-022-03403-7

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  • Relationship between cellular morphology and abnormality of SWI/SNF complex subunits in pancreatic undifferentiated carcinoma. Reviewed International journal

    Yamamoto T, Kohashi K, Yamada Y, Kawata J, Sakihama K, Matsuda R, Koga Y, Aishima S, Nakamura M, Oda Y.

    J Cancer Res Clin Oncol.   148 ( 11 )   2945 - 2957   2022.11

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    DOI: doi: 10.1007/s00432-021-03860-8.

  • Association of thyroid transcription factor-1 (TTF-1) expression with efficacy of PD-1/PD-L1 inhibitors plus pemetrexed and platinum chemotherapy in advanced non-squamous non-small cell lung cancer. Reviewed International journal

    Ibusuki R, Yoneshima Y, Hashisako M, Matsuo N, Harada T, Tsuchiya-Kawano Y, Kishimoto J, Ota K, Shiraishi Y, Iwama E, Tanaka K, Oda Y, Okamoto I.

    Transl Lung Cancer Res.   11 ( 11 )   2208 - 2215   2022.11

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    DOI: doi: 10.21037/tlcr-22-393.

  • A CASE OF MALIGNANT PERIVASCULAR EPITHELIOID CELL TUMOR (PEComa) OF THE VAGINA

    Hino, Y; Tamaki, A; Kawakubo, N; Hamada, H; Ono, H; Koga, Y; Kohashi, K; Oga, S; Oda, Y; Tajiri, T

    PEDIATRIC BLOOD & CANCER   69   2022.11   ISSN:1545-5009 eISSN:1545-5017

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  • HISTOLOGICAL AND GENETIC ANALYSIS OF CONGENITAL MESOBLASTIC NEPHROMA

    Tamaki, A; Kawakubo, N; Hino, Y; Hamada, H; Takemoto, J; Oda, Y; Tajiri, T

    PEDIATRIC BLOOD & CANCER   69   2022.11   ISSN:1545-5009 eISSN:1545-5017

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  • ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway (vol 22, pg 9, 2022)

    Guan, W; Nakata, K; Sagara, A; Iwamoto, C; Endo, S; Matsuda, R; Matsumoto, S; Ikenaga, N; Shindo, K; Moriyama, T; Onishi, H; Ohuchida, K; Oda, Y; Nakamura, M

    PANCREATOLOGY   22 ( 7 )   1059 - 1059   2022.11   ISSN:1424-3903 eISSN:1424-3911

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    Figures in this paper contained western blots where the same membrane was probed repeatedly by the indicated antibodies, occasionally resulting in similar band shapes among the individual panels. Moreover, in Figure 5, results from the same membrane were presented in two columns with the panels for the α-SMA and β-actin blots shown twice for easier comparison. We apologize for any misunderstanding this may have caused.

    DOI: 10.1016/j.pan.2022.08.013

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  • A CASE OF PULMONARY SCLEROSING PENUMOCYTOMA IN A 13-YEAR-OLD BOY

    Hamada, H; Kawakubo, N; Hino, Y; Tamaki, A; Kohashi, K; Oda, Y; Tajiri, T

    PEDIATRIC BLOOD & CANCER   69   2022.11   ISSN:1545-5009 eISSN:1545-5017

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  • Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5

    Kimura, I; Yamasoba, D; Tamura, T; Nao, N; Suzuki, T; Oda, Y; Mitoma, S; Ito, J; Nasser, H; Zahradnik, J; Uriu, K; Fujita, S; Kosugi, Y; Wang, L; Tsuda, M; Kishimoto, M; Ito, H; Suzuki, R; Shimizu, R; Begum, MM; Yoshimatsu, K; Kimura, KT; Sasaki, J; Sasaki-Tabata, K; Yamamoto, Y; Nagamoto, T; Kanamune, J; Kobiyama, K; Asakura, H; Nagashima, M; Sadamasu, K; Yoshimura, K; Shirakawa, K; Takaori-Kondo, A; Kuramochi, J; Schreiber, G; Ishii, KJ; Hashiguchi, T; Ikeda, T; Saito, A; Fukuhara, T; Tanaka, S; Matsuno, K; Sato, K

    CELL   185 ( 21 )   3992 - +   2022.10   ISSN:0092-8674 eISSN:1097-4172

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    After the global spread of the SARS-CoV-2 Omicron BA.2, some BA.2 subvariants, including BA.2.9.1, BA.2.11, BA.2.12.1, BA.4, and BA.5, emerged in multiple countries. Our statistical analysis showed that the effective reproduction numbers of these BA.2 subvariants are greater than that of the original BA.2. Neutralization experiments revealed that the immunity induced by BA.1/2 infections is less effective against BA.4/5. Cell culture experiments showed that BA.2.12.1 and BA.4/5 replicate more efficiently in human alveolar epithelial cells than BA.2, and particularly, BA.4/5 is more fusogenic than BA.2. We further provided the structure of the BA.4/5 spike receptor-binding domain that binds to human ACE2 and considered how the substitutions in the BA.4/5 spike play roles in ACE2 binding and immune evasion. Moreover, experiments using hamsters suggested that BA.4/5 is more pathogenic than BA.2. Our multiscale investigations suggest that the risk of BA.2 subvariants, particularly BA.4/5, to global health is greater than that of original BA.2.

    DOI: 10.1016/j.cell.2022.09.018

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  • Direct visualization of cooperative adsorption of a string-like molecule onto a solid

    Morimitsu, Y; Matsuno, H; Oda, Y; Yamamoto, S; Tanaka, K

    SCIENCE ADVANCES   8 ( 41 )   eabn6349   2022.10   ISSN:2375-2548

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    Natural systems, composite materials, and thin-film devices adsorb macromolecules in different phases onto their surfaces. In general, polymer chains form interfacial layers where their aggregation states and thermal molecular motions differ from the bulk. Here, we visualize well-defined double-stranded DNAs (dsDNAs) using atomic force microscopy and molecular dynamics simulations to clarify the adsorption mechanism of polymer chains onto solid surfaces. Initially, short and long dsDNAs are individually and cooperatively adsorbed, respectively. Cooperative adsorption involves intertwining of multiple chains. The dependence of adsorption on the chain affects the formation of the interfacial layer, realizing different mechanical properties of DNA/filler bulk composites. These findings will contribute to the development of light and durable polymer composites and films for various industrial, biomedical, and environmental applications.

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  • Hemiarthroplasty for tumor-induced osteomalacia caused by tumor localized in femoral head: a case report

    Arita, S; Nishino, T; Mitani, Y; Sakashita, K; Totsuka, S; Watanabe, R; Mishima, H; Kawai, H; Matsubara, D; Oda, Y; Yamazaki, M

    JOURNAL OF SURGICAL CASE REPORTS   2022 ( 10 )   rjac478   2022.10   ISSN:2042-8812

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  • A novel fast kilovoltage switching dual-energy computed tomography technique with deep learning: utility for non-invasive assessments of liver fibrosis. Reviewed International journal

    Wada N, Fujita N, Ishimatsu K, Takao S, Yoshizumi T, Miyazaki Y, Oda Y, Nishie A, Ishigami K, Ushijima Y.

    Eur J Radiol.   155   110461   2022.10

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    DOI: doi: 10.1016/j.ejrad.2022.110461.

  • Chronological changes in the expression pattern of hippocampal prion proteins during disease progression in sporadic creutzfeldt-Jakob disease MM1 subtype. Reviewed International journal

    Yagita K, Noguchi H, Koyama S, Hamasaki H, Komori T, Aishima S, Kosaka T, Ueda M, Komohara Y, Watanabe A, Sasagasako N, Ninomiya T, Oda Y, Honda H.

    J Neuropathol Exp Neurol.   81 ( 11 )   900 - 909   2022.10

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    DOI: doi: 10.1093/jnen/nlac078.

  • A new scoring system for the grading of conventional chondrosarcoma: Its clinicopathological significance. Reviewed International journal

    Susuki Y, Yamada Y, Ito Y, Kawaguchi K, Furukawa H, Kohashi K, Kinoshita I, Taguchi K, Nakashima Y, Oda Y.

    Pathol Res Pract.   ( 238 )   154125   2022.10

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    DOI: doi: 10.1016/j.prp.2022.154125.

  • Solid-type poorly differentiated adenocarcinoma of the stomach: A characteristic morphology reveals a distinctive immunoregulatory tumor microenvironment. Reviewed International journal

    Kawatoko S, Kohashi K, Torisu T, Sasaki T, Umekita S, Oki E, Nakamura M, Kitazono T, Oda Y.

    Pathol Res Pract.   ( 238 )   154124   2022.10

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    DOI: doi: 10.1016/j.prp.2022.154124.

  • Denervation caused by extended pelvic lymph node dissection worsens early urinary continence after robot-assisted radical prostatectomy

    Lee, K; Shiota, M; Takamatsu, D; Ushijima, M; Okabe, A; Kajioka, S; Goto, S; Kinoshita, F; Matsumoto, T; Monji, K; Kashiwagi, E; Inokuchi, J; Oda, Y; Eto, M

    INTERNATIONAL JOURNAL OF UROLOGY   29   22 - 22   2022.10   ISSN:0919-8172 eISSN:1442-2042

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  • Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant

    Saito, A; Tamura, T; Zahradnik, J; Deguchi, S; Tabata, K; Anraku, Y; Kimura, I; Ito, J; Yamasoba, D; Nasser, H; Toyoda, M; Nagata, K; Uriu, K; Kosugi, Y; Fujita, S; Shofa, M; Begum, MM; Shimizu, R; Oda, Y; Suzuki, R; Ito, H; Nao, N; Wang, L; Tsuda, M; Yoshimatsu, K; Kuramochi, J; Kita, S; Sasaki-Tabata, K; Fukuhara, H; Maenaka, K; Yamamoto, Y; Nagamoto, T; Asakura, H; Nagashima, M; Sadamasu, K; Yoshimura, K; Ueno, T; Schreiber, G; Takaori-Kondo, A; Shirakawa, K; Sawa, H; Irie, T; Hashiguchi, T; Takayama, K; Matsuno, K; Tanaka, S; Ikeda, T; Fukuhara, T; Sato, K

    CELL HOST & MICROBE   30 ( 9 )   1540 - +   2022.9   ISSN:1931-3128 eISSN:1934-6069

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    The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency, but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5.

    DOI: 10.1016/j.chom.2022.10.003

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  • M-CSFR expression in the embryonal component of hepatoblastoma and cell-to-cell interaction between macrophages and hepatoblastoma. Reviewed International journal

    Li L, Irie T, Yoshii D, Komohara Y, Fujiwara Y, Esumi S, Kadohisa M, Honda M, Suzu S, Matsuura T, Kohashi K, Oda Y, Hibi T.

    Med Mol Morphol.   55 ( 3 )   236 - 247   2022.9

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    DOI: doi: 10.1007/s00795-022-00323-y.

  • Immunohistochemistry reveals an increased number of ganglion cells in the normal‑size plexus, as a pathological feature of immaturity of ganglia. Reviewed International journal

    32 ( 5 )   2022.9

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  • Targeting hepatic oxidative stress rescues bone loss in liver fibrosis. Reviewed International journal

    Sonoda S, Murata S, Yamaza H, Yuniartha R, Fujiyoshi J, Yoshimaru K, Matsuura T, Oda Y, Ohga S, Tajiri T, Taguchi T, Yamaza T.

    Mol Metab.   ( 66 )   101599   2022.9

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    DOI: doi: 10.1016/j.molmet.2022.101599.

  • Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy. Reviewed International journal

    Okuda S, Ohuchida K, Shindo K, Moriyama T, Kawata J, Tamura K, Sada M, Nagayoshi K, Mizuuchi Y, Ikenaga N, Nakata K, Oda Y, Nakamura M.

    Oncol Lett.   24 ( 3 )   2022.9

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    DOI: DOI: 10.3892/ol.2022.13457

  • Neuroectodermal rosettes in immature teratomas are not the counterpart of embryonal tumours with multilayered rosettes. Reviewed International journal

    Magarifuchi N, Yamada Y, Oishi Y, Kato K, Taguchi K, Oda Y.

    Anticancer Res.   42 ( 9 )   4337 - 4344   2022.9

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    DOI: doi:10.21873/anticanres.15934

  • Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model. Reviewed International journal

    Yamaguchi K, Yoshihiro T, Ariyama H, Ito M, Nakano M, Semba Y, Nogami J, Tsuchihashi K, Yamauchi T, Ueno S, Isobe T, Shindo K, Moriyama T, Ohuchida K, Nakamura M, Nagao Y, Ikeda T, Hashizume M, Konomi H, Torisu T, Kitazono T, Kanayama T, Tomita H, Oda Y, Kusaba H, Maeda T, Akashi K, Baba E.

    Gastric Cancer.   25 ( 5 )   862 - 878   2022.9

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    DOI: doi: 10.1007/s10120-022-01307-8.

  • Pancreatic hamartoma: detection of harbouring NAB2-STAT6 fusion gene. Reviewed International journal

    Tanigawa M, Koga Y, Naito Y, Yamaguchi H, Iwasaki T, Kohashi K, Ohike N, Hanada K, Higashi M, Komatsu M, Imai H, Yamakita K, Nagakawa T, Okabe Y, Kato S, Noguchi H, Nakayama T, Yasuda M, Kusano H, Akiba J, Oda Y, Yano H.

    Histopathology.   81 ( 3 )   319 - 328   2022.9

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    DOI: doi: 10.1111/his.14703.

  • Pancreatic hamartoma: detection of harbouring <i>NAB2::STAT6</i> fusion gene

    Tanigawa, M; Koga, Y; Naito, Y; Yamaguchi, H; Iwasaki, T; Kohashi, K; Ohike, N; Hanada, K; Higashi, M; Komatsu, M; Imai, H; Yamakita, K; Nagakawa, T; Okabe, Y; Kato, S; Noguchi, H; Nakayama, T; Yasuda, M; Kusano, H; Akiba, J; Oda, Y; Yano, H

    HISTOPATHOLOGY   81 ( 3 )   319 - 328   2022.9   ISSN:0309-0167 eISSN:1365-2559

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    Hamartomas in the pancreas are rare and are often histologically and morphologically similar to solitary fibrous tumours (SFTs). We examined the differences between hamartomas and SFTs at the molecular level. Methods and results: Thirteen patients histopathologically diagnosed with pancreatic hamartoma were included in the study. We also performed STAT6 immunohistochemistry (IHC), which is used in the diagnosis of SFT. Furthermore, for the three cases in which RNA was extracted, reverse transcription polymerase chain reaction to search for NAB2::STAT6 fusions was used. Macroscopically, 13 patients had well-demarcated tumour lesions. Histologically, no islets of Langerhans were observed in the lesions, acinar tissue and ducts were unevenly distributed and elastic fibres were not observed around the ducts by Elastica van Gieson staining. One case contained a lipomatous hamartoma composed mainly of adipose tissue. Seven of the 13 cases demonstrated expression of STAT6 in the nuclei of intervening spindle cells. NAB2::STAT6 fusions were observed in two of the three cases in which RNA was extracted. These two cases also demonstrated STAT6 expression in spindle cells using STAT6 IHC. In one case of lipomatous hamartoma, we did not confirm NAB2::STAT6 fusion or STAT6 expression in STAT6 IHC. Conclusion: Of the 13 patients histopathologically diagnosed with hamartoma, two demonstrated NAB2::STAT6 fusions, suggesting the existence of pancreatic hamartomas with molecular-level components identical to those of SFT.

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  • Panuveitis induced by donor-derived CD8<sup>+</sup> T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia

    Takeda A., Sakoda T., Yawata N., Kato K., Hasegawa E., Shima T., Hikita S., Yoshitomi K., Takenaka K., Oda Y., Akashi K., Sonoda K.H.

    American Journal of Ophthalmology Case Reports   27   101673   2022.9   ISSN:24519936

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    Purpose: This article presents a case of panuveitis that occurred after unrelated allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a patient with lymphoma-type human T-cell leukemia virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL). Observations: A 45-year-old man developed unilateral panuveitis 18 months after undergoing allo-HSCT. He underwent vitrectomy, and depositions of grey-white granules localized on the retinal artery were observed in the eye. Cytological examination of the vitreous aspirates showed that the atypical lymphoid cells stained positive for CD3 and CD8, but negative for CD4, B-cell markers, and cytomegalovirus antigen. Interphase fluorescence in situ hybridization using X‐ and Y‐chromosome probes revealed complete donor chimerism in CD8+ T cells in the vitreous aspirates. Conclusions and importance: Donor-derived CD8+ T lymphocytes can induce panuveitis like HTLV-1-assiciated uveitis after allo-HSCT in patients with ATL. Pathological diagnosis of vitreous infiltration by vitrectomy is helpful in patients with ATL. Donor-derived CD8+ T lymphocytes-induced panuveitis is recurrent but susceptible to regional corticosteroid treatment.

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  • Tropomyosin-related Kinase B Is Potentially a Biomarker of Prognosis and Therapeutic Target for Malignant Thymic Epithelial Tumors. Reviewed International journal

    Ozono K, Onishi H, Iwamoto N, Nakamura K, Miyoshi K, Nakamura M, Oda Y.

    Anticancer Res.   42 ( 7 )   3779 - 3787   2022.8

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  • Nuclear β-catenin translocation plays a key role in osteoblast differentiation of giant cell tumor of bone. Reviewed International journal

    12 ( 1 )   13438   2022.8

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    DOI: doi: 10.1038/s41598-022-17728-5.

  • Substantial improvement of histopathological diagnosis by whole-slide image-based remote consultation. Reviewed International journal

    Shinohara S, Bychkov A, Munkhdelger J, Kuroda K, Yoon HS, Fujimura S, Tabata K, Furusato B, Niino D, Morimoto S, Yao T, Itoh T, Aoyama H, Tsuyama N, Mikami Y, Nagao T, Ikeda T, Fukushima N, Harada O, Kiyokawa T, Yoshimi N, Aishima S, Maeda I, Mori I, amanegi K, Tsuneyama K, Katoh R, Izumi M, Oda Y, Fukuoka J.

    Virchows Arch.   481 ( 2 )   295 - 305   2022.8

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    DOI: doi: 10.1007/s00428-022-03327-2.

  • Relationship between consolidation tumor ratio and tumor-infiltrating lymphocytes in small-sized lung adenocarcinoma. Reviewed International journal

    Ono Y, Tagawa T, Kinoshita F, Haratake N, Takada K, Kohno M, Takenaka T, Kamitani T, Shimokawa M, Oda Y, Mori M, Yoshizumi T.

    Thorac Cancer.   13 ( 15 )   2134 - 2141   2022.8

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    DOI: doi: 10.1111/1759-7714.14524

  • Characteristics of colorectal neuroendocrine tumors in patients prospectively enrolled in a Japanese multicenter study: a first report from the C-NET STUDY

    Sekiguchi, M; Hotta, K; Takeuchi, Y; Tanaka, S; Yamamoto, H; Shinmura, K; Harada, K; Uraoka, T; Hisabe, T; Sano, Y; Kondo, H; Horimatsu, T; Kikuchi, H; Kawamura, T; Nagata, S; Yamamoto, K; Tajika, M; Tsuji, S; Kusaka, T; Okuyama, Y; Yoshida, N; Moriyama, T; Hasebe, A; So, S; Kobara, H; Kashida, H; Miyanaga, R; Kato, S; Hayashi, Y; Sada, M; Fukuzawa, M; Kato, H; Takayama, T; Konishi, J; Matsushita, HO; Narasaka, T; Ohata, K; Togashi, K; Nakamura, H; Moriichi, K; Oda, Y; Kanda, N; Kuwai, T; Terai, S; Sanomura, M; Kitamura, S; Miyamoto, H; Kiriyama, S; Mizuno, C; Saito, Y; Sekine, S; Ito, S; Nakahira, H; Oka, S; Hayashi, Y; Yoshimura, K; Ishikawa, H; Matsuda, T

    JOURNAL OF GASTROENTEROLOGY   57 ( 8 )   547 - 558   2022.8   ISSN:0944-1174 eISSN:1435-5922

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    Background: This is the first report from a multicenter prospective cohort study of colorectal neuroendocrine tumor (NET), the C-NET STUDY, conducted to assess the long-term outcomes of the enrolled patients. This report aimed to elucidate the clinicopathological features of the enrolled patients and lesions. Methods: Colorectal NET patients aged 20–74 years were consecutively enrolled and followed up at 50 institutions. The baseline characteristics and clinicopathological findings at enrollment and treatment were assessed. Results: A total of 495 patients with 500 colorectal NETs were included. The median patient age was 54 years, and 85.3% were asymptomatic. The most frequent lesion location was the lower rectum (88.0%); 99.4% of the lesions were clinically diagnosed to be devoid of metastatic findings, and 95.4% were treated with endoscopic resection. Lesions < 10 mm comprised 87.0% of the total, 96.6% had not invaded the muscularis propria, and 92.6% were classified as WHO NET grade 1. Positive lymphovascular involvement was found in 29.2% of the lesions. Its prevalence was high even in small NETs with immunohistochemical/special staining for pathological assessment (26.4% and 40.9% in lesions sized < 5 mm and 5–9 mm, respectively). Among 70 patients who underwent radical surgery primarily or secondarily, 18 showed positive lymph node metastasis. Conclusions: The characteristics of real-world colorectal NET patients and lesions are elucidated. The high positivity of lymphovascular involvement in small NETs highlights the necessity of assessing the clinical significance of positive lymphovascular involvement based on long-term outcomes, which will be examined in later stages of the C-NET STUDY. Trial registration number: UMIN000025215.

    DOI: 10.1007/s00535-022-01877-5

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  • High-risk HPV-related Squamous Cell Carcinoma in the Conjunctiva and Lacrimal sac: clinicopathologic Characteristics and Diagnostic Utility of p16 and Rb Immunohistochemistry. Reviewed International journal

    Hongo T, Yamamoto H, Tanabe M, Yasumatsu R, Kuga R, Miyazaki Y, Jiromaru R, Hashimoto K, Tateishi Y, Sonoda KH, Nakagawa T, Oda Y.

    Am J Surg Pathol.   46 ( 7 )   977 - 987   2022.7

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    DOI: doi: 10.1097/PAS.0000000000001857.

  • An efficient procedure for the recovery of DNA from formalin-fixed paraffin-embedded tissue sections. Reviewed International journal

    Oba U, Kohashi K, Sangatsuda Y, Oda Y, Sonoda KH, Ohga S, Yoshimoto K, Arai Y, Yachida S, Shibata T, Ito T, Miura F.

    Biol Methods Protoc.   7 ( 1 )   bpac014   2022.7

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    DOI: doi: 10.1093/biomethods/bpac014.

  • Cyclin-dependent kinase 8 is an independent prognosticator in uterine leiomyosarcoma. Reviewed International journal

    Yasutake N, Iwasaki T, Yamamoto H, Sonoda K, Kodama K, Okugawa K, Asanoma K, Yahata H, Kato K, Oda Y.

    Pathol Res Pract.   235   153920   2022.7

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    DOI: doi: 10.1016/j.prp.2022.153920.

  • Palisading-like arrangement of immature ganglion cell in myenteric ganglia is a unique pathological feature of immaturity of ganglia. Reviewed International journal

    Yoshimaru K, Tamaki A, Matsuura T, Kohashi K, Kajihara K, Irie K, Hino Y, Uchida Y, Toriigahara Y, Kawano Y, Shirai T, Oda Y, Tajiri T, Taguchi T.

    J Pediatr Surg.   57 ( 7 )   1269 - 1273   2022.7

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    DOI: doi: 10.1016/j.jpedsurg.2022.02.035.

  • A deep learning-based approach for the diagnosis of adrenal adenoma: A new trial using CT. Reviewed International journal

    Kusunoki M, Nakayama T, Nishie A, Yamashita Y, Kikuchi K, Eto M, Oda Y, Ishigami K.

    Br J Radiol.   95 ( 1135 )   20211066   2022.7

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    DOI: doi: 10.1259/bjr.20211066.

  • High-risk HPV-related Squamous Cell Carcinoma in the Conjunctiva and Lacrimal sac Clinicopathologic Characteristics and Diagnostic Utility of p16 and Rb Immunohistochemistry

    Hongo, T; Yamamoto, H; Tanabe, M; Yasumatsu, R; Kuga, R; Miyazaki, Y; Jiromaru, R; Hashimoto, K; Tateishi, Y; Sonoda, KH; Nakagawa, T; Oda, Y

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY   46 ( 7 )   977 - 987   2022.7   ISSN:0147-5185 eISSN:1532-0979

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    High-risk human papillomavirus (HPV) infection in conjunctival and lacrimal sac squamous cell carcinomas (SCCs) has been sporadically reported; however, its prevalence, clinicopathologic significance and surrogate markers have not been fully elucidated. Here, we attempted to clarify these questions in Japanese patients with conjunctiva and lacrimal sac SCCs. We retrospectively collected 51 conjunctival SCC and 7 lacrimal sac SCC samples and analyzed them for (1) transcriptionally active high-risk HPV infection using messenger RNA in situ hybridization and (2) protein expressions of p16 and Rb using immunohistochemistry (IHC). Among a total of 58 cases, 25 (43.1%) and 16 (27.6%) tumors were positive for p16-IHC and HPV in situ hybridization, respectively. Ten (19.6%) of the 51 conjunctival SCCs, especially in the palpebral conjunctiva, and 6 (85.7%) of the 7 lacrimal sac SCCs were positive for high-risk HPV. High-risk HPV infection was significantly associated with younger patients, nonkeratinizing SCC histology, p16-positivity and partial loss of Rb expression, but not with recurrence risk. Notably, p16-IHC was not a perfect surrogate marker for high-risk HPV infection; only 64% (16/25) of p16-positive tumors were positive for high-risk HPV. In contrast, the p16+/Rb partial loss pattern was exclusively correlated with high-risk HPV-positivity. The results suggest that the combination of p16 and Rb expression patterns by IHC could be a useful method to predict high-risk HPV infection in conjunctival and lacrimal sac SCCs. HPV infection may be of less prognostic value in this field of cancers.

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  • Approach for reclassification of collecting duct carcinoma and comparative histopathological analysis with SMARCB1/INI1-deficient renal cell carcinoma and fumarate hydratase-deficient renal cell carcinoma. Reviewed International journal

    Kiyozawa D, Kohashi K, Takamatsu D, Iwasaki T, Shibata D, Tomonaga T, Tateishi Y, Eto M, Kinjo M, Nishiyama K, Taguchi K, Oshiro Y, Kuboyama Y, Furuya M, Oda Y.

    Hum Pathol.   124   36 - 44   2022.6

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    DOI: doi: 10.1016/j.humpath.2022.03.002.

  • Prediction of pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma using 2-[ 18 F]-fluoro-2-deoxy-d-glucose positron-emission tomography. Reviewed International journal

    Tabata K, Nishie A, Shimomura Y, Isoda T, Kitamura Y, Nakata K, Yamada Y, Oda Y, Ishigami K, Baba S.

    Clin Radiol.   77 ( 6 )   436 - 442   2022.6

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    DOI: doi: 10.1016/j.crad.2022.03.001.

  • Impact of JMJD6 on intrahepatic cholangiocarcinoma. Reviewed International journal

    Kosai-Fujimoto Y, Itoh S, Yugawa K, Fukuhara T, Okuzaki D, Toshima T, Harada N, Oda Y, Yoshizumi T, Mori M.

    Mol Clin Oncol.   17 ( 2 )   131   2022.6

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    DOI: doi: 10.3892/mco.2022.2564.

  • Histological background of dedifferentiated solitary fibrous tumour. Reviewed International journal

    Yamada Y, Kohashi K, Kinoshita I, Yamamoto H, Iwasaki T, Yoshimoto M, Ishihara S, Toda Y, Ito Y, Kuma Y, Yamada-Nozaki Y, Koga Y, Hashisako M, Kiyozawa D, Kitahara D, Narutomi F, Kuboyama Y, Nakamura T, Inoue T, Mukai M, Honda Y, Toyokawa G, Tsuchihashi K, Fushimi F, Taguchi K, Nishiyama K, Tamiya S, Oshiro Y, Furue M, Nakashima Y, Suzuki S, Iwaki T, Oda Y.

    J Clin Pathol.   75 ( 6 )   397 - 403   2022.6

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    DOI: doi: 10.1136/jclinpath-2020-207311.

  • Artificial intelligence for segmentation of bladder tumor cystoscopic images performed by U-Net with dilated convolution. Reviewed International journal

    Mutaguchi J, Morooka KI, Kobayashi S, Umehara A, Miyauchi S, Kinoshita F, Inokuchi J, Oda Y, Kurazume R, Eto M.

    J Endourol.   36 ( 6 )   827 - 834   2022.6

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    DOI: doi: 10.1089/end.2021.0483.

  • RNF43 as a predictor of malignant transformation of pancreatic mucinous cystic neoplasm. Reviewed International journal

    Sakihama K, Koga Y, Yamamoto T, Shimada Y, Yamada Y, Kawata J, Shindo K, Nakamura M, Oda Y.

    Virchows Arch.   480 ( 6 )   1189 - 1199   2022.6

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    DOI: doi: 10.1007/s00428-022-03277-9.

  • Prediction of pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma using 2-[<SUP>18</SUP>F]-fluoro-2-deoxy-D-glucose positron-emission tomography

    Tabata, K; Nishie, A; Shimomura, Y; Isoda, T; Kitamura, Y; Nakata, K; Yamada, Y; Oda, Y; Ishigami, K; Baba, S

    CLINICAL RADIOLOGY   77 ( 6 )   436 - 442   2022.6   ISSN:0009-9260 eISSN:1365-229X

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    AIM: To determine whether the pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma (PDAC) can be predicted using 2-[18F]-fluoro-2-deoxy-D-glucose positron-emission tomography (F-18 FDG-PET). MATERIALS AND METHODS: Twenty-eight patients with PDAC who underwent only neoadjuvant chemotherapy (NAC) before surgery were enrolled in the study. All patients had F-18 FDG-PET examinations before NAC. The resected specimen was pathologically evaluated according to the Classification of Pancreatic Carcinoma (7th edn). Patients were categorised into a non-response group and a response group based on the pathological findings. The non-response group (Grades 1a and 1b) showed ≤50% necrosis in the specimen, while the specimens of the response group (Grades 2–3) showed >50% necrosis. The maximum standardised uptake values (SUVmax) of the tumours on F-18 FDG-PET were measured. The mean values of SUVmax were compared between the two groups. The diagnostic performance of SUVmax in distinguishing the two groups was also evaluated using receiver operating characteristic analysis. RESULTS: The mean SUVmax of the response group was higher than that of the non-response group (9.00 ± 1.78 versus 4.26 ± 2.35; p<0.001). The optimal cut-off value of SUVmax was 9.28 for distinguishing the two groups. The sensitivity, specificity, and accuracy for the prediction in the response group were 80%, 95.7%, and 92.9%, respectively. CONCLUSIONS: SUVmax on F-18 FDG-PET may be useful as a biomarker to predict the pathological response to NAC in patients with PDAC.

    DOI: 10.1016/j.crad.2022.03.001

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  • <i>RNF43</i> as a predictor of malignant transformation of pancreatic mucinous cystic neoplasm

    Sakihama, K; Koga, Y; Yamamoto, T; Shimada, Y; Yamada, Y; Kawata, J; Shindo, K; Nakamura, M; Oda, Y

    VIRCHOWS ARCHIV   480 ( 6 )   1189 - 1199   2022.6   ISSN:0945-6317 eISSN:1432-2307

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    Mucinous cystic neoplasm (MCN) of the pancreas rarely progresses to invasive carcinoma, but few studies have analyzed genomic alterations involved in its malignant transformation. The relationships of ring finger protein 43 (RNF43) mutations with cytological atypia, RNF43 protein expression, and Wnt signaling proteins in MCN remain unclear. This study included 106 MCN cases, classified into 89 low-grade dysplasia (LG), 9 high-grade dysplasia (HG), and 8 invasive carcinoma (INV). We analyzed HG/INV and LG lesions of 9 HG/INV cases and LG lesions of 9 LG cases using targeted sequencing and confirmed the protein expression of RNF43 and β-catenin. The frequency of RNF43 mutations was significantly higher in HG/INV cases than in LG cases. Furthermore, HG/INV lesions (56%) and LG lesions (33%) of HG/INV cases possessed RNF43 mutation, whereas no such mutation was detected in any LG cases. The expression of RNF43 was reduced in 71% of HG/INV cases and significantly correlated with histological grade and aberrant expression of β-catenin. In 3 of 5 RNF43-mutated cases, the expression of RNF43 was reduced, but there was no significant correlation between RNF43 mutation and protein expression. MCNs frequently harbored KRAS mutations, at rates of 100% in HG/INV lesions and 50% in LG lesions of HG/INV and LG cases. There was no significant difference in mutation frequency in LG lesions between HG/INV and LG cases. These results suggest that RNF43 mutations may be involved in and predictive of malignant transformation from an early stage of MCN.

    DOI: 10.1007/s00428-022-03277-9

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  • Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: A possible association with TP53 mutation and loss of H3K27 trimethylation. Reviewed International journal

    Ishihara S, Yamamoto H, Iwasaki T, Toda Y, Yamamoto T, Yoshimoto M, Ito Y, Susuki Y, Kawaguchi K, Kinoshita I, Yamada Y, Kohashi K, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Kakuda Y, Nakashima Y, Oda Y.

    Mod Pathol.   35 ( 5 )   640 - 648   2022.5

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    DOI: doi: 10.1038/s41379-021-00972-x.

  • Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine. Reviewed International journal

    Tsukahara S, Shiota M, Takamatsu D, Nagakawa S, Matsumoto T, Kiyokoba R, Yagi M, Setoyama D, Noda N, Matsumoto S, Hayashi T, Contreras-Sanz A, Black PC, Inokuchi J, Kohashi K, Oda Y, Uchiumi T, Eto M, Kang D.

    Sci Rep.   12 ( 1 )   8535   2022.5

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    DOI: doi: 10.1038/s41598-022-12528-3.

  • Three-dimensional imaging of intramural perineural invasion in colorectal cancer: Three-dimensional reconstruction approach with multiple immunohistochemically stained sections. Reviewed International journal

    Miyashita Y, Ikeda T, Shinto E, Okano S, Korehisa S, Shimazaki H, Oki E, Ueno H, Oda Y, Mori M.

    Pathol Int.   72 ( 5 )   293 - 299   2022.5

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    DOI: doi: 10.1111/pin.13222.

  • Tumor progression by epithelial-mesenchymal transition in ARID1A- and SMARCA4-aberrant solid-type poorly differentiated gastric adenocarcinoma. Reviewed International journal

    Sasaki T, Kohashi K, Kawatoko S, Ihara E, Oki E, Nakamura M, Ogawa Y, Oda Y.

    Virchows Arch.   480 ( 5 )   1063 - 1075   2022.5

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    DOI: doi: 10.1007/s00428-021-03261-9.

  • Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma. Reviewed International journal

    Shimada E, Matsumoto Y, Nakagawa M, Susuki Y, Endo M, Setsu N, Fujiwara T, Iida K, Nabeshima A, Yahiro K, Kimura A, Hirose T, Kanahori M, Oyama R, Oda Y, Nakashima Y.

    Br J Cancer.   126 ( 9 )   1289 - 1300   2022.5

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    DOI: doi: 10.1038/s41416-021-01695-1.

  • Impact of nuclear factor erythroid 2-related factor 2 in hepatocellular carcinoma: Cancer metabolism and immune status. Reviewed International journal

    Iseda N, Itoh S, Yoshizumi T, Tomiyama T, Morinaga A, Yugawa K, Shimokawa M, Shimagaki T, Wang H, Kurihara T, Kitamura Y, Nagao Y, Toshima T, Harada N, Kohashi K, Baba S, Ishigami K, Oda Y, Mori M.

    Hepatol Commun.   6 ( 4 )   665 - 678   2022.4

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    DOI: doi: 10.1002/hep4.1838.

  • NECTIN4 expression in sebaceous and sweat gland carcinoma. Reviewed International journal

    Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Oda Y, Kaku-Ito Y.

    Eur J Dermatol.   32 ( 2 )   181 - 186   2022.4

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    DOI: doi: 10.1684/ejd.2022.4241.

  • Dental pulp stem cells as a therapy for congenital entero-neuropathy. Reviewed International journal

    Yoshimaru K, Yamaza T, Kajioka S, Sonoda S, Yanagi Y, Matsuura T, Yoshizumi J, Oda Y, Iwata N, Takai C, Nakayama S, Taguchi T.

    Sci Rep.   12 ( 1 )   6990   2022.4

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    DOI: doi: 10.1038/s41598-022-10077-3.

  • Clinical, radiological, and histopathological characteristics of periosteal chondrosarcoma with a focus on the frequency of medullary invasion. Reviewed International journal

    Nakagawa M, Endo M, Susuki Y, Yokoyama N, Maekawa A, Nabeshima A, Iida K, Fujiwara T, Setsu N, Matsunobu T, Matsumoto Y, Yokoyama R, Yamada Y, Kohashi K, Yamamoto H, Oda Y, Iwamoto Y, Nakashima Y.

    J Clin Med.   11 ( 7 )   2062   2022.4

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    DOI: doi: 10.3390/jcm11072062.

  • One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: A real-world prospective study. Reviewed International journal

    Matsuno Y, Torisu T, Umeno J, Shibata H, Hirano A, Fuyuno Y, Okamoto Y, Fujioka S, Kawasaki K, Moriyama T, Nagasue T, Zeze K, Hirakawa Y, Kawatoko S, Koga Y, Oda Y, Esaki M, Kitazono T.

    Intest Res.   20 ( 2 )   260 - 268   2022.4

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    DOI: doi: 10.5217/ir.2021.00124.

  • Myxoid type and non-myxoid type of intimal sarcoma in large vessels and heart: review of histological and genetic profiles of 20 cases. Reviewed International journal

    Yamada Y, Kinoshita I, Miyazaki Y, Tateishi Y, Kuboyama Y, Iwasaki T, Kohashi K, Yamamoto H, Ishihara S, Toda Y, Ito Y, Susuki Y, Kawaguchi K, Hashisako M, Yamada-Nozaki Y, Kiyozawa D, Mori T, Yamamoto T, Tsuchihashi K, Kuriwaki K, Mukai M, Kawai M, Suzuki K, Nishimura H, Bando K, Masumoto J, Fukushima M, Motoshita J, Mori H, Shiose A, Oda Y.

    Virchows Arch.   480 ( 4 )   919 - 925   2022.4

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    DOI: doi: 10.1007/s00428-022-03293-9.

  • Long-term follow up after sentinel node biopsy alone for early-stage cervical cancer. Reviewed International journal

    Yahata H, Kodama K, Okugawa K, Hachisuga K, Yasutake N, Maenohara S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Asanoma K, Kobayashi H, Sonoda K, Baba S, Ishigami K, Ohishi Y, Oda Y, Kato K.

    Gynecol Oncol.   165 ( 1 )   149 - 154   2022.4

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    DOI: doi: 10.1016/j.ygyno.2022.01.031.

  • An analysis of 20 cases of radiation-associated sarcoma, including 4 cases treated by carbon ion radiotherapy. Reviewed International journal

    Negishi T, Matsunobu A, Endo M, Yokoyama R, Kusano S, Furubayashi N, Taguchi K, Shioyama Y, Iida K, Fujiwara T, Setsu N, Matsumoto Y, Nakashima Y, Kohashi K, Yamamoto H, Oda Y, Nakamura M.

    Oncology.   100 ( 3 )   148 - 154   2022.4

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    DOI: doi: 10.1159/000521504.

  • Serum uric acid levels and nephrosclerosis in a population-based autopsy study: the hisayama study. Reviewed International journal

    Maki K, Hata J, Sakata S, Oishi E, Furuta Y, Nakano T, Oda Y, Kitazono T, Ninomiya T.

    Am J Nephrol.   53 ( 1 )   69 - 77   2022.4

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    DOI: doi: 10.1159/000521426.

  • Diagnostic utility of ERG immunostaining in dermatofibroma. Reviewed International journal

    Yamada Y, Ichiki T, Susuki Y, Yamada-Nozaki Y, Tateishi Y, Furue M, Oda Y.

    (Online ahead of print.) J Clin Pathol.   2022.3

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    DOI: doi: 10.1136/jclinpath-2022-208158.

  • Myeloid-derived suppressor cell infiltration is associated with a poor prognosis in patients with hepatocellular carcinoma. Reviewed International journal

    Tomiyama T, Itoh S, Iseda N, Toshida K, Morinaga A, Yugawa K, Fujimoto YK, Tomino T, Kurihara T, Nagao Y, Morita K, Harada N, Kohashi K, Oda Y, Mori M, Yoshizumi T.

    Oncol Lett.   23 ( 3 )   93   2022.3

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    DOI: doi: 10.3892/ol.2022.13213.

  • Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma. Reviewed International journal

    Tanaka Y, Murata M, Tanegashima K, Oda Y, Ito T.

    Sci Rep.   12 ( 1 )   4031   2022.3

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    DOI: doi: 10.1038/s41598-022-07727-x.

  • Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses. Reviewed International journal

    Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M.

    J Exp Clin Cancer Res.   41 ( 1 )   89   2022.3

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    DOI: doi: 10.1186/s13046-022-02301-9.

  • IL-34 in hepatoblastoma cells potentially promote tumor progression via autocrine and paracrine mechanisms. Reviewed International journal

    Irie T, Yoshii D, Komohara Y, Fujiwara Y, Kadohisa M, Honda M, Suzu S, Matsuura T, Kohashi K, Oda Y, Hibi T.

    Cancer Med.   11 ( 6 )   1441 - 1453   2022.3

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    DOI: doi: 10.1002/cam4.4537.

  • Lymphoid and myeloid proliferative disorders associated with inflammatory bowel disease: a clinicopathological study of 15 cases. Reviewed International journal

    Hori Y, Yamamoto H, Kawatoko S, Nozaki Y, Torisu T, Kato K, Koga Y, Miyoshi H, Ohshima K, Tateishi Y, Nakamura S, Kitazono T, Oda Y.

    Hum Pathol.   120   88 - 98   2022.2

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    DOI: doi: 10.1016/j.humpath.2021.12.010.

  • Stratification of prostate cancer patients into low- and high-grade groups using multiparametric magnetic resonance radiomics with dynamic contrast-enhanced image joint histograms. Reviewed International journal

    Urakami A, Arimura H, Takayama Y, Kinoshita F, Ninomiya K, Imada K, Watanabe S, Nishie A, Oda Y, Ishigami K.

    Prostate.   82 ( 3 )   330 - 344   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1002/pros.24278.

  • Clinical impact of HSD3B1 polymorphism by metastatic volume and somatic HSD3B1 alterations in advanced prostate cancer. Reviewed International journal

    Shiota M, Fujimoto N, Sekino Y, Tsukahara S, Nagakawa S, Takamatsu D, Abe T, Kinoshita F, Ueda S, Ushijima M, Matsumoto T, Kashiwagi E, Inokuchi J, Uchiumi T, Oda Y, Eto M.

    Andrologia.   54 ( 1 )   e14307   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/and.14307.

  • Clinicopathological and histopathological review of dedifferentiated liposarcoma: a comprehensive study of 123 primary tumours. Reviewed International journal

    Mori T, Yamada Y, Kinoshita I, Kohashi K, Yamamoto H, Ito Y, Susuki Y, Kawaguchi K, Nakashima Y, Oda Y.

    Histopathology.   80 ( 3 )   538 - 557   2022.2

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    DOI: doi: 10.1111/his.14588.

  • Clinical impact of <i>HSD3B1</i> polymorphism by metastatic volume and somatic <i>HSD3B1</i> alterations in advanced prostate cancer

    Shiota, M; Fujimoto, N; Sekino, Y; Tsukahara, S; Nagakawa, S; Takamatsu, D; Abe, T; Kinoshita, F; Ueda, S; Ushijima, M; Matsumoto, T; Kashiwagi, E; Inokuchi, J; Uchiumi, T; Oda, Y; Eto, M

    ANDROLOGIA   54 ( 1 )   e14307   2022.2   ISSN:0303-4569 eISSN:1439-0272

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    This study aimed to investigate the significance of HSD3B1 gene status including germline polymorphism and somatic alterations in prostate cancer. Patients with prostate cancer treated with androgen-deprivation therapy, as well as tissues from metastatic prostate cancer, were included. Genomic DNA was extracted from cancer tissues and whole blood samples, and HSD3B1 (rs1047303, 1245C) was genotyped by Sanger sequencing. The association of HSD3B1 genotype with progression-free survival according to metastatic volume was examined. Copy number alteration and gene expression of HSD3B1 were examined in prostate cancer cells and public datasets. Among 194 patients, 121 and 73 patients were categorized into low- and high-volume diseases respectively. In multivariate analysis, the adrenal-permissive genotype (AC/CC) was significantly associated with increased risk of progression compared with the adrenal-restrictive genotype (AA) in low volume, but not high-volume diseases. Somatic mutation in HSD3B1 was detected at least in two cases of castration-resistant prostate cancer tissues. HSD3B1 amplification and overexpression were detected in castration-resistant prostate cancer cells and tissues. The current findings suggest that both germline and somatic alterations of HSD3B1 may cooperatively promote castration resistance in prostate cancer and HSD3B1 as a promising biomarker for precision medicine, warranting further investigations.

    DOI: 10.1111/and.14307

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  • PD-L1/IDO1 expression and tumor-infiltrating lymphocyte (TIL) in solid type poorly differentiated gastric adenocarcinoma

    Kawatoko, S; Kohashi, K; Sasaki, T; Oda, Y

    CANCER SCIENCE   113   2022.2   ISSN:1347-9032 eISSN:1349-7006

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  • HSD3B1 polymorphism and genomic HSD3B1 aberrations in prostate cancer

    Shiota, M; Fujimoto, N; Sekino, Y; Tsukahara, S; Nagakawa, S; Takamatsu, D; Abe, T; Kinoshita, F; Ueda, S; Matsumoto, T; Kashiwagi, E; Takeuchi, A; Inokuchi, J; Uchiumi, T; Oda, Y; Eto, M

    CANCER SCIENCE   113   1591 - 1591   2022.2   ISSN:1347-9032 eISSN:1349-7006

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  • Comparative Evaluation of Plasma Metabolomic Data from Multiple Laboratories

    Nishiumi, S; Izumi, Y; Hirayama, A; Takahashi, M; Nakao, M; Hata, K; Saigusa, D; Hishinuma, E; Matsukawa, N; Tokuoka, SM; Kita, Y; Hamano, F; Okahashi, N; Ikeda, K; Nakanishi, H; Saito, K; Hirai, MY; Yoshida, M; Oda, Y; Matsuda, F; Bamba, T

    METABOLITES   12 ( 2 )   2022.2   ISSN:2218-1989 eISSN:2218-1989

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    In mass spectrometry-based metabolomics, the differences in the analytical results from different laboratories/machines are an issue to be considered because various types of machines are used in each laboratory. Moreover, the analytical methods are unique to each laboratory. It is important to understand the reality of inter-laboratory differences in metabolomics. Therefore, we have evaluated whether the differences in analytical methods, with the exception sample pretreatment and including metabolite extraction, are involved in the inter-laboratory differences or not. In this study, nine facilities are evaluated for inter-laboratory comparisons of metabolomic analysis. Identical dried samples prepared from human and mouse plasma are distributed to each laboratory, and the metabolites are measured without the pretreatment that is unique to each laboratory. In these measurements, hydrophilic and hydrophobic metabolites are analyzed using 11 and 7 analytical methods, respectively. The metabolomic data acquired at each laboratory are integrated, and the differences in the metabolomic data from the laboratories are evaluated. No substantial difference in the relative quantitative data (human/mouse) for a little less than 50% of the detected metabolites is observed, and the hydrophilic metabolites have fewer differences between the laboratories compared with hydrophobic metabolites. From evaluating selected quantitatively guaranteed metabolites, the proportion of metabolites without the inter-laboratory differences is observed to be slightly high. It is difficult to resolve the inter-laboratory differences in metabolomics because all laboratories cannot prepare the same analytical environments. However, the results from this study indicate that the inter-laboratory differences in metabolomic data are due to measurement and data analysis rather than sample preparation, which will facilitate the understanding of the problems in metabolomics studies involving multiple laboratories.

    DOI: 10.3390/metabo12020135

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  • Clinicopathological and prognostic significance of TFE3 in papillary renal carcinoma (PRCC)

    Takamatsu, D; Kohashi, K; Kiyozawa, D; Takeuchi, A; Inokuchi, J; Eto, M; Oda, Y

    CANCER SCIENCE   113   1583 - 1583   2022.2   ISSN:1347-9032 eISSN:1349-7006

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  • ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway. Reviewed International journal

    Guan W, Nakata K, Sagara A, Iwamoto C, Endo S, Matsuda R, Matsumoto S, Ikenaga N, Shindo K, Moriyama T, Onishi H, Ohuchida K, Oda Y, Nakamura M.

    Pancreatology.   22 ( 1 )   9 - 19   2022.1

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    DOI: doi: 10.1016/j.pan.2021.09.012.

  • Merkel cell polyomavirus-negative Merkel cell carcinoma is associated with JAK-STAT and MEK-ERK pathway activation. Reviewed International journal

    Iwasaki T, Hayashi K, Matsushita M, Nonaka D, Kohashi K, Kuwamoto S, Umekita Y, Oda Y.

    Cancer Sci.   113 ( 1 )   251 - 260   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/cas.15187.

  • Evaluation of clinical significance of lymphovascular space invasion in stage IA endometrial cancer. Reviewed International journal

    Okugawa K, Yahata H, Hachisuga K, Tomonobe H, Yasutake N, Kodama K, Kenjo H, Yagi H, Ohgami T, Yasunaga M, Onoyama I, Asanoma K, Hori E, Ohishi Y, Oda Y, Kato K.

    Oncology.   100 ( 4 )   195 - 202   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1159/000521382.

  • The effects of ARID1A mutations on colorectal cancer and associations with PD-L1 expression by stromal cells. Reviewed International journal

    Kamori T, Oki E, Shimada Y, Hu Q, Hisamatsu Y, Ando K, Shimokawa M, Wakai T, Oda Y, Mori M.

    Cancer Rep (Hoboken).   5 ( 1 )   e1420   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1002/cnr2.1420.

  • Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults: The Hisayama study. Reviewed International journal

    32 ( 1 )   e13014   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/bpa.13014

  • Standardization of evaluation method and prognostic significance of histological response to preoperative chemotherapy in high-grade non-round cell soft tissue sarcomas. Reviewed International journal

    Oda Y, Tanaka K, Hirose T, Hasegawa T, Hiruta N, Hisaoka M, Yoshimoto M, Otsuka H, Bekki H, Ishii T, Endo M, Kunisada T, Hiruma T, Tsuchiya H, Katagiri H, Matsumoto Y, Kawai A, Nakayama R, Kawashima H, Takenaka S, Emori M, Watanuki M, Yoshida Y, Okamoto T, Mizusawa J, Fukuda H, Ozaki T, Iwamoto Y, Nojima T.

    BMC Cancer.   22 ( 1 )   94   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1186/s12885-022-09195-y.

  • The utility of core-needle tumor biopsy for pediatric patients. Reviewed International journal

    Kawakubo N, Takemoto J, Koga Y, Hino Y, Tamaki A, Kohashi K, Ono H, Oda Y, Ohga S, Tajiri T.

    Pediatr Int.   64 ( 1 )   e15228   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/ped.15228.

  • TROP2 expression in sebaceous and sweat gland carcinoma. Invited Reviewed International journal

    Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Ichiki T, Iwasaki T, Oda Y, Kaku-Ito Y.

    J Clin Med.   11 ( 3 )   607   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.3390/jcm11030607.

  • Clinicopathological and prognostic significance of H3K27 methylation status in malignant peripheral nerve sheath tumor: correlation with skeletal muscle differentiation. Reviewed International journal

    Ito Y, Kohashi K, Endo M, Yoshimoto M, Ishihara S, Toda Y, Susuki Y, Kawaguchi K, Furukawa H, Tateishi Y, Yamada Y, Kinoshita I, Mori T, Yamamoto H, Nakashima Y, Oda Y.

    Virchows Arch.   479 ( 6 )   1233 - 1244   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1007/s00428-021-03189-0.

  • Prognostic implication of desmoplastic stroma in synovial sarcoma: a histological review. Reviewed International journal

    Toda Y, Yamada Y, Kohashi K, Ishihara S, Ito Y, Susuki Y, Kawaguchi K, Kinoshita I, Kiyozawa D, Mori T, Kuboyama Y, Tateishi Y, Yamamoto H, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Mawatari M, Oda Y.

    Pathol Res Pract.   ( 228 )   153668   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • PD-L1 expression, tumor-infiltrating lymphocytes, mismatch repair deficiency, EGFR alteration and HPV infection in sinonasal squamous cell carcinoma. Reviewed International journal

    Hongo T, Yamamoto H, Jiromaru R, Yasumatsu R, Kuga R, Nozaki Y, Hashimoto K, Matsuo M, Wakasaki T, Tamae A, Taguchi K, Toh S, Masuda M, Nakagawa T, Oda Y.

    Mod Pathol.   34 ( 11 )   1966 - 1978   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41379-021-00868-w.

  • Prognostic impact of Vessels that Encapsulate Tumor Cluster (VETC) in patients who underwent liver transplantation for hepatocellular carcinoma. Reviewed International journal

    Kawasaki J, Toshima T, Yoshizumi T, Itoh S, Mano Y, Wang H, Iseda N, Harada N, Oda Y, Mori M.

    Ann Surg Oncol.   28 ( 13 )   8186 - 8195   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1245/s10434-021-10209-5.

  • Endometrial endometrioid carcinoma, G1, is more aggressive in the elderly than in the young. Reviewed International journal

    Hachisuga K, Ohishi Y, Tomonobe H, Yahata H, Kato K, Oda Y.

    Histopathology.   79 ( 5 )   708 - 719   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/his.14400.

  • Biliary atresia-specific deciduous pulp stem cells feature biliary deficiency. Reviewed International journal

    Sonoda S, Yoshimaru K, Yamaza H, Yuniartha R, Matsuura T, Yamauchi-Tomoda E, Murata S, Nishida K, Oda Y, Ohga S, Tajiri T, Taguchi T, Yamaza T.

    Stem Cell Res Ther.   12 ( 1 )   582   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1186/s13287-021-02652-8.

    Repository Public URL: https://hdl.handle.net/2324/7172586

  • The Japanese Society of Pathology Practical Guidelines on the handling of pathological tissue samples for cancer genomic medicine. Reviewed International journal

    Hatanaka Y, Kuwata T, Morii E, Kanai Y, Ichikawa H, Kubo T, Hatanaka KC, Sakai K, Nishio K, Fujii S, Okamoto W, Yoshino T, Ochiai A, Oda Y.

    Pathol Int.   71 ( 11 )   725 - 740   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/pin.13170.

  • PD-L1 expression, tumor-infiltrating lymphocytes, mismatch repair deficiency, EGFR alteration and HPV infection in sinonasal squamous cell carcinoma. Reviewed International journal

    Hongo T, Yamamoto H, Jiromaru R, Yasumatsu R, Kuga R, Nozaki Y, Hashimoto K, Matsuo M, Wakasaki T, Tamae A, Taguchi K, Toh S, Masuda M, Nakagawa T, Oda Y.

    Mod Pathol.   34 ( 11 )   1966 - 1978   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41379-021-00868-w.

  • Tumor microenvironment in giant cell tumor of bone: evaluation of PD-L1 expression and SIRPα infiltration after denosumab treatment. Reviewed International journal

    11 ( 1 )   14821   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41598-021-94022-w.

  • Does the use of peripheral immune‐related markers indicate whether to administer pazopanib, trabectedin, or eribulin to advanced soft tissue sarcoma patients? Reviewed International journal

    10 ( 21 )   4972   2021.10

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  • Lymphocyte-C-reactive protein ratio as a prognostic marker associated with the tumor immune microenvironment in intrahepatic cholangiocarcinoma. Reviewed International journal

    Yugawa K, Itoh S, Yoshizumi T, Morinaga A, Iseda N, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.

    Int J Clin Oncol.   26 ( 10 )   1901 - 1910   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1007/s10147-021-01962-4.

  • Lymphocyte-to-C-reactive protein ratio as a prognostic factor for hepatocellular carcinoma. Reviewed International journal

    Iseda N, Itoh S, Yoshizumi T, Tomiyama T, Morinaga A, Shimagaki T, Wang H, Kurihara T, Toshima T, Nagao Y, Harada N, Oda Y, Mori M.

    Int J Clin Oncol.   26 ( 10 )   1890 - 1900   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1007/s10147-021-01985-x.

  • Pathological review of cardiac amyloidosis using autopsy cases in a single Japanese institution. Reviewed International journal

    Tateishi Y, Yamada Y, Katsuki M, Nagata T, Yamamoto H, Kohashi K, Koga Y, Hashisako M, Kiyozawa D, Mori T, Kuboyama Y, Kakinokizono A, Miyazaki Y, Yamaguchi A, Tsutsui H, Ninomiya T, Naiki H, Oda Y.

    Pathol Res Pract.   227   153635   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.prp.2021.153635.

  • Pathologic diabetic nephropathy in autopsied diabetic cases with normoalbuminuria from a japanese community-based study. Reviewed International journal

    Sasaki T, Nakagawa K, Hata J, Hirakawa Y, Shibata M, Nakano T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T.

    Kidney Int Rep.   6 ( 12 )   3035 - 3044   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.ekir.2021.09.007.

  • Serum NT-proBNP levels and histopathological myocardial fibrosis in autopsied cases from a Japanese community: The Hisayama Study. Reviewed International journal

    Sasaki T, Izumaru K, Hata J, Sakata S, Oishi E, Nagata T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T.

    J Cardiol.   78 ( 3 )   237 - 243   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.jjcc.2021.03.014.

  • Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Reviewed International journal

    Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP.

    Cell.   184 ( 18 )   4753 - 4771   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.cell.2021.07.020.

  • Expression of CD44 variant 9 induces chemoresistance of gastric cancer by controlling intracellular reactive oxygen spices accumulation. Reviewed International journal

    Jogo T, Oki E, Nakanishi R, Ando K, Nakashima Y, Kimura Y, Saeki H, Oda Y, Maehara Y, Mori M.

    Gastric Cancer.   24 ( 5 )   1089 - 1099   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1007/s10120-021-01194-5.

  • Identification of SLC38A7 as a prognostic marker and potential therapeutic target of lung squamous cell carcinoma. Reviewed International journal

    Haratake N, Hu Q, Okamoto T, Jogo T, Toyokawa G, Kinoshita F, Takenaka T, Tagawa T, Iseda N, Itoh S, Yamada Y, Oda Y, Shimokawa M, Kikutake C, Suyama M, Unoki M, Sasaki H, Mori M.

    Ann Surg.   274 ( 3 )   500 - 507   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1097/SLA.0000000000005001

  • Prognostic implications of the coexisting precursor lesion types in invasive gallbladder cancer. Reviewed International journal

    Mochidome N, Koga Y, Ohishi Y, Miyazaki T, Matsuda R, Yamada Y, Aishima S, Nakamura M, Oda Y.

    Hum Pathol.   114   44 - 53   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.humpath.2021.05.001.

  • Effect of the 2013 ASCO-CAP HER2 testing guideline on the management of IHC/HER2 2+ invasive breast cancer. Reviewed International journal

    Yamada M, Kubo M, Yamamoto H, Yamashita N, Kai M, Zaguirre K, Kaneshiro K, Shimazaki A, Hayashi S, Kawaji H, Mori M, Oda Y, Nakamura M.

    Anticancer Res.   41 ( 8 )   4143 - 4149   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.21873/anticanres.15217.

  • Genetic and transcriptomic analyses in a rare case of HPV-related oropharyngeal squamous cell carcinoma combined with small cell carcinoma. Reviewed International journal

    Sato K, Nishiyama K, Taguchi K, Jiromaru R, Yamamoto H, Matsunaga A, Nagata R, Rikimaru F, Toh S, Higaki Y, Oda S, Nakagawa T, Masuda M.

    Cold Spring Harb Mol Case Stud.   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1101/mcs.a006102.

  • Quantification of HER family dimers by proximity ligation assay and its clinical evaluation in non-small cell lung cancer patients treated with osimertinib. Reviewed International journal

    Liu R, Ota K, Iwama E, Yoneshima Y, Tanaka K, Inoue H, Tagawa T, Oda Y, Mori M, Nakanishi Y, Okamoto I.

    Lung Cancer.   158   156 - 161   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.lungcan.2021.05.023.

  • Clinical significance of signal regulatory protein alpha (SIRPα) expression in esophageal squamous cell carcinoma. Reviewed International journal

    112 ( 8 )   3018 - 3028   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/cas.14971.

  • The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma. Reviewed International journal

    Ishihara S, Iwasaki T, Kohashi K, Yamada Y, Toda Y, Ito Y, Susuki Y, Kawaguchi K, Takamatsu D, Kawatoko S, Kiyozawa D, Mori T, Kinoshita I, Yamamoto H, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Oda Y.

    J Cancer Res Clin Oncol.   147 ( 7 )   2003 - 2011   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1007/s00432-021-03616-4.

  • Trop2 expression in extramammary paget’s disease and normal skin. Reviewed International journal

    22 ( 14 )   7706   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.3390/ijms22147706.

  • CDK4: a novel therapeutic target for extramammary paget's disease. Reviewed International journal

    Hashimoto H, Kaku-Ito Y, Oda Y, Ito T.

    Front Oncol.   11   710378   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.3389/fonc.2021.710378.

  • Morphological, immunohistochemical, and genomic analyses of papillary renal neoplasm with reverse polarity. Reviewed International journal

    Kiyozawa D, Kohashi K, Takamatsu D, Yamamoto T, Eto M, Iwasaki T, Motoshita J, Shimokama T, Kinjo M, Oshiro Y, Yonemasu H, Oda Y.

    Hum Pathol.   112   48 - 58   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.humpath.2021.03.009.

  • Neoantigens elicit T cell responses in breast cancer. Reviewed International journal

    Morisaki T, Kubo M, Umebayashi M, Yew PY, Yoshimura S, Park JH, Kiyotani K, Kai M, Yamada M, Oda Y, Nakamura Y, Morisaki T, Nakamura M.

    Sci Rep.   11 ( 1 )   13590   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41598-021-91358-1.

  • Brachyury expression in intracranial SMARCB1-deficient tumors: important points for distinguishing poorly differentiated chordoma from atypical teratoid/rhabdoid tumor. Reviewed International journal

    Kohashi K, Yamamoto H, Yamada Y, Kinoshita I, Oda Y.

    Hum Pathol.   112   1 - 8   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.humpath.2021.03.001.

  • Cytolytic activity score as a biomarker for antitumor immunity and clinical outcome in patients with gastric cancer. Reviewed International journal

    Hu Q, Nonaka K, Wakiyama H, Miyashita Y, Fujimoto Y, Jogo T, Hokonohara K, Nakanishi R, Hisamatsu Y, Ando K, Kimura Y, Masuda T, Oki E, Mimori K, Oda Y, Mori M.

    Cancer Med.   10 ( 9 )   3129 - 3138   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1002/cam4.3828.

  • Myxoepithelioid tumor with chordoid feature: A clinicopathological, immunohistochemical, and genetic study of 14 cases of SMARCB1/INI1-deficient soft-tissue neoplasm. Reviewed International journal

    Kinoshita I, Kohashi K, Yamamoto H, Yamada Y, Inoue T, Higaki K, Teramoto N, Oshiro Y, Nakashima Y, Oda Y.

    Histopathology.   79 ( 4 )   629 - 641   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/his.14393.

  • Salivary duct carcinoma with rhabdoid features-no or aberrant expression of e-cadherin and genetic changes in CDH1: Immunohistochemical and genetic analyses of 17 cases. Reviewed International journal

    Kusafuka K, Yamada H, Ishino K, Maeda M, Yamanegi K, Baba S, Ohuchi T, Inagaki H, Yamamoto H, Iwasaki T, Tsuchiya C, Sugimura H, Suzuki M.

    Am J Surg Pathol.   45 ( 4 )   439 - 449   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1097/PAS.0000000000001672.

  • ARID1A deficiency is associated with high programmed death ligand 1 expression in hepatocellular carcinoma. Reviewed International journal

    Iseda N, Itoh S, Yoshizumi T, Yugawa K, Morinaga A, Tomiyama T, Toshima T, Kohashi K, Oda Y, Mori M.

    Hepatol Commun.   5 ( 4 )   675 - 688   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1002/hep4.1659.

  • Prognostic impact of tumor microvessels in intrahepatic cholangiocarcinoma: association with tumor-infiltrating lymphocytes. Reviewed International journal

    Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.

    Mod Pathol.   34 ( 4 )   798 - 807   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41379-020-00702-9.

  • A deep learning model to detect pancreatic ductal adenocarcinoma on endoscopic ultrasound-guided fine-needle biopsy. Reviewed International journal

    Naito Y, Tsuneki M, Fukushima N, Koga Y, Higashi M, Notohara K, Aishima S, Ohike N, Tajiri T, Yamaguchi H, Fukumura Y, Kojima M, Hirabayashi K, Hamada Y, Norose T, Kai K, Omori Y, Sukeda A, Noguchi H, Uchino K, Itakura J, Okabe Y, Yamada Y, Akiba J, Kanavati F, Oda Y, Furukawa T, Yano H.

    Sci Rep.   11 ( 1 )   8454 - 8454   2021.4

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    DOI: doi: 10.1038/s41598-021-87748-0.

  • Association of PD-L1 and IDO1 expression with JAK-STAT pathway activation in soft-tissue leiomyosarcoma. Reviewed International journal

    Iwasaki T, Kohashi K, Toda Y, Ishihara S, Yamada Y, Oda Y.

    J Cancer Res Clin Oncol.   147 ( 5 )   1451 - 1463   2021.3

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    DOI: doi: 10.1007/s00432-020-03390-9.

  • Impact of metabolic activity in hepatocellular carcinoma: Association with immune status and vascular formation. Reviewed International journal

    Itoh S, Yoshizumi T, Kitamura Y, Yugawa K, Iseda N, Shimagaki T, Nagao Y, Toshima T, Harada N, Kohashi K, Baba S, Ishigami K, Oda Y, Mori M.

    Hepatol Commun.   5 ( 7 )   1278 - 1289   2021.3

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    DOI: doi: 10.1002/hep4.1715.

  • Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status. Reviewed International journal

    Yugawa K, Itoh S, Iseda N, Kurihara T, Kitamura Y, Toshima T, Harada N, Kohashi K, Baba S, Ishigami K, Oda Y, Yoshizumi T, Mori M.

    Sci Rep.   11 ( 1 )   5845 - 5845   2021.3

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    DOI: doi: 10.1038/s41598-021-85186-6.

  • Nectin cell adhesion molecule 4 (NECTIN4) expression in cutaneous squamous cell carcinoma: A new therapeutic target? Reviewed International journal

    Tanaka Y, Murata M, Oda Y, Furue M, Ito T.

    Biomedicines.   9 ( 4 )   355 - 355   2021.3

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    DOI: doi: 10.3390/biomedicines9040355.

  • Immunogenic characteristics of microsatellite instability-low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses. Reviewed International journal

    Imamura Y, Toihata T, Haraguchi I, Ogata Y, Takamatsu M, Kuchiba A, Tanaka N, Gotoh O, Mori S, Nakashima Y, Oki E, Mori M, Oda Y, Taguchi K, Yamamoto M, Morita M, Yoshida N, Baba H, Mine S, Nunobe S, Sano T, Noda T, Watanabe M.

    Int J Cancer.   148 ( 5 )   1260 - 1275   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1002/ijc.33322.

  • GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer. Reviewed International journal

    Oncol Rep.   45 ( 3 )   997 - 1010   2021.3

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    DOI: doi: 10.3892/or.2021.7947.

  • Pan-tropomyosin receptor kinase immunoreactivity, ETV6-NTRK3 fusion subtypes, and RET rearrangement in salivary secretory carcinoma. Reviewed International journal

    Yamamoto H, Nozaki Y, Sugii A, Taguchi K, Hongo T, Jiromaru R, Sato M, Nakano T, Hashimoto K, Fujiwara M, Oda Y.

    Hum Pathol.   ( 109 )   37 - 44   2021.3

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    DOI: doi: 10.1016/j.humpath.2020.11.017.

  • The forkhead box M1 (FOXM1) expression and antitumor effect of FOXM1 inhibition in malignant rhabdoid tumor. Reviewed International journal

    Shibui Y, Kohashi K, Tamaki A, Kinoshita I, Yamada Y, Yamamoto H, Taguchi T, Oda Y.

    J Cancer Res Clin Oncol.   147 ( 5 )   1499 - 1518   2021.3

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    DOI: doi: 10.1007/s00432-020-03438-w.

  • Histological categorization of the desmoplastic reaction is a predictor of patient prognosis in oesophageal squamous cell carcinoma. Reviewed International journal

    Sakai A, Nakashima Y, Miyashita Y, Ao T, Kimura Y, Shinto E, Oki E, Shimokawa M, Ueno H, Oda Y, Mori M.

    Histopathology.   2021.2

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    DOI: doi: 10.1111/his.14357. Online ahead of print.

  • CMTM6 stabilizes PD-L1 expression and is a new prognostic impact factor in hepatocellular carcinoma. Reviewed International journal

    Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.

    Hepatol Commun.   5 ( 2 )   334 - 348   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1002/hep4.1643.

  • Cancer-associated fibroblasts promote hepatocellular carcinoma progression through downregulation of exosomal miR-150-3p. Reviewed International journal

    Yugawa K, Yoshizumi T, Mano Y, Itoh S, Harada N, Ikegami T, Kohashi K, Oda Y, Mori M.

    Eur J Surg Oncol.   47 ( 2 )   384 - 393   2021.2

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    DOI: doi: 10.1016/j.ejso.2020.08.002.

  • Clinicopathologic significance of EGFR mutation and HPV infection in sinonasal squamous cell carcinoma.  Reviewed International journal

    45 ( 1 )   108 - 118   2021.1

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    DOI: doi: 10.1097/PAS.0000000000001566.

  • Impact of capicua on pancreatic cancer progression. Reviewed International journal

    Yoshiya S, Itoh S, Yoshizumi T, Yugawa K, Kurihara T, Toshima T, Harada N, Hashisako M, Yonemasu H, Fukuzawa K, Oda Y, Mori M.

    Ann Surg Oncol. Online ahead of print.   2021.1

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  • Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma. Reviewed International journal

    Yamashita K, Kohashi K, Yamada Y, Akatsuka S, Ikuta K, Nishida Y, Toyokuni S, Oda Y.

    Genes Chromosomes Cancer.   60 ( 1 )   26 - 37   2021.1

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    DOI: doi: 10.1002/gcc.22899.

  • Genomic sequencing of cancer-related genes in sinonasal squamous cell carcinoma and coexisting inverted papilloma. Invited Reviewed International journal

    Uchi R, Jiromaru R, Yasumatsu R, Yamamoto H, Hongo T, Manako T, Sato K, Hashimoto K, Wakasaki T, Matsuo M, Nakagawa T.

    Anticancer Res.   41 ( 1 )   71 - 79   2021.1

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    DOI: doi: 10.21873/anticanres.14752.

  • Pathological evaluation of tumor grade for salivary adenoid cystic carcinoma: A proposal of an objective grading system. Reviewed International journal

    Morita N, Murase T, Ueda K, Nagao T, Kusafuka K, Nakaguro M, Urano M, Taguchi KI, Yamamoto H, Kano S, Tada Y, Tsukahara K, Okami K, Onitsuka T, Fujimoto Y, Kawakita D, Sakurai K, Nagao T, Hanai N, Kawata R, Hato N, Otsuki N, Nibu KI, Inagaki H.

    2021.1

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    DOI: doi: 10.1111/cas.14790.

  • Comprehensive molecular profiling broadens treatment options for breast cancer patients. Reviewed International journal

    Kawaji H, Kubo M, Yamashita N, Yamamoto H, Kai M, Kajihara A, Yamada M, Kurata K, Kaneshiro K, Harada Y, Hayashi S, Shimazaki A, Mori H, Akiyoshi S, Oki E, Oda Y, Baba E, Mori M, Nakamura M.

    Cancer Med.   10 ( 2 )   529 - 539   2021.1

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    DOI: doi: 10.1002/cam4.3619.

  • Validity of the prognostication tool PREDICT version 2.2 in Japanese breast cancer patients. Reviewed International journal

    Zaguirre K, Kai M, Kubo M, Yamada M, Kurata K, Kawaji H, Kaneshiro K, Harada Y, Hayashi S, Shimazaki A, Morisaki T, Mori H, Oda Y, Chen S, Moriyama T, Shimizu S, Nakamura M.

    Cancer Med.   2021.1

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    DOI: doi: 10.1002/cam4.3713. Online ahead of print.

  • Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells. Reviewed International journal

    Yuniartha R, Yamaza T, Sonoda S, Yoshimaru K, Matsuura T, Yamaza H, Oda Y, Ohga S, Taguchi T.

    Stem Cell Res Ther.   12 ( 1 )   57   2021.1

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    DOI: doi: 10.1186/s13287-020-02113-8.

  • Reevaluation of Concurrent AChE and HE staining for Hirschsprung's disease. Reviewed International journal

    Yoshimaru K, Matsuura T, Yanagi Y, Obata S, Takahashi Y, Kajihara K, Ohmori A, Irie K, Hino Y, Shibui Y, Tamaki A, Kohashi K, Oda Y, Taguchi T.

    Pediatr Int. 2021 Jan   2021.1

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    DOI: doi: 10.1111/ped.14596. Online ahead of print.

  • Gene amplification of YB-1 in castration-resistant prostate cancer in association with aberrant androgen receptor expression. Reviewed International journal

    Shiota M, Sekino Y, Tsukahara S, Abe T, Kinoshita F, Imada K, Ueda S, Ushijima M, Nagakawa S, Matsumoto T, Kashiwagi E, Takeuchi A, Inokuchi J, Uchiumi T, Oda Y, Eto M.

    Cancer Sci.   112 ( 1 )   323 - 330   2021.1

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    DOI: doi: 10.1111/cas.14695.

  • Comprehensive molecular and clinicopathological profiling of desmoid tumours. Reviewed International journal

    Kohsaka S, Hirata M, Ikegami M, Ueno T, Kojima S, Sakai T, Ito K, Naka N, Ogura K, Kawai A, Iwata S, Okuma T, Yonemoto T, Kobayashi H, Suehara Y, Hiraga H, Kawamoto T, Motoi T, Oda Y, Matsubara D, Matsuda K, Nishida Y, Mano H. doi: 10.1016/j.ejca.2020.12.001.

    Eur J Cancer.   145 ( 109 )   120   2021.1

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  • Interleukin-38 promotes tumor growth through regulation of CD8 + tumor-infiltrating lymphocytes in lung cancer tumor microenvironment. Reviewed International journal

    Kinoshita F, Tagawa T, Akamine T, Takada K, Yamada Y, Oku Y, Kosai K, Ono Y, Tanaka K, Wakasu S, Oba T, Osoegawa A, Shimokawa M, Oda Y, Hoshino T, Mori M.

    Cancer Immunol Immunother.   70 ( 1 )   123 - 135   2021.1

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    DOI: doi: 10.1007/s00262-020-02659-9.

  • The clinical and histopathological features of cutaneous immune-related adverse events and their outcomes. Reviewed International journal

    Hashimoto H, Ito T, Ichiki T, Yamada Y, Oda Y, Furue M.

    J. Clin. Med.   1 - 13   2021.1

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    DOI: DOI: 10.22541/au.159863177.79676202

  • p16 Overexpression and Rb Loss Correlate with High-risk HPV Infection in Oropharyngeal Squamous Cell Carcinoma. Reviewed International journal

    Jiromaru R, Yamamoto H, Yasumatsu R, Hongo T, Nozaki Y, Nakano T, Hashimoto K, Nakagawa T, Oda Y.

    Histopathology.   2021.1

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    DOI: doi: 10.1111/his.14337. Online ahead of print.

  • PD‑L1 and IDO‑1 expression in undifferentiated pleomorphic sarcoma: The associations with tumor infiltrating lymphocytes, dMMR and HLA class I. Reviewed International journal

    45 ( 1 )   379 - 389   2021.1

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    DOI: doi: 10.3892/or.2020.7837.

  • Chronic inflammatory changes and oxidative stress in the background of "pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm". Reviewed International journal

    Matsuda R, Miyasaka Y, Yamada Y, Kawata J, Sakihama K, Yamamoto T, Saeki K, Yamamoto H, Ohishi Y, Koga Y, Nakamura M, Oda Y.

    Virchows Arch.   477 ( 6 )   799 - 806   2020.12

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    DOI: doi: 10.1007/s00428-020-02844-2.

  • Impact of DNA integrity on the success rate of tissue-based next-generation sequencing: lessons from nationwide cancer genome screening project SCRUM-Japan GI-SCREEN. Reviewed International journal

    Kuwata T, Wakabayashi M, Hatanaka Y, Morii E, @Oda Y, Taguchi K, Noguchi M, Ishikawa Y, Nakajima T, Sekine S, Nomura S, Okamoto W, Fujii S, Yoshino T; SCRUM-Japan GI-SCREEN Pathology Group.

    Pathol Int.   70 ( 12 )   932 - 942   2020.12

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  • Autocrine leukemia inhibitory factor promotes esophageal squamous cell carcinoma progression via Src family kinase-dependent Yes-associated protein activation. Reviewed International journal

    Kawazoe T, Saeki H, Oki E, Oda Y, Meahara Y, Mori M, Taniguchi K.

    Mol Cancer Res.   18 ( 12 )   1876 - 1888   2020.12

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    DOI: doi: 10.1158/1541-7786.MCR-20-0186.

  • Frequent MN1 gene mutations in malignant peripheral nerve sheath tumor. Reviewed International journal

    Kinoshita I, Yamada Y, Kohashi K, Yamamoto H, Iwasaki T, Ishihara S, Toda YU, Ito Y, Susuki Y, Kawaguchi K, Ichiki T, Sato Y, Furue M, Nakashima Y, Oda Y.

    Anticancer Res.   40 ( 11 )   6221 - 6228   2020.11

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    DOI: doi: 10.21873/anticanres.14642.

  • CMTM6 stabilizes PD-L1 expression and is a new prognostic impact factor in hepatocellular carcinoma. Reviewed International journal

    Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.

    Hepatol Commun. 2020 Nov   5 ( 2 )   334 - 348   2020.11

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    DOI: doi: 10.1002/hep4.1643.

  • Congenital biliary dilatation in the era of laparoscopic surgery, focusing on the high incidence of anatomical variations of the right hepatic artery. Reviewed International journal

    Mori Y, Nakata K, Aly MYF, Ideno N, Ikenaga N, Okabe Y, Ishigami K, Oda Y, Nakamura M.

    J Hepatobiliary Pancreat Sci.   27 ( 11 )   870 - 876   2020.11

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    DOI: doi: 10.1002/jhbp.819.

  • Clinical significance of preoperative inflammatory markers in non-small cell lung cancer patients: A multicenter retrospective study. Reviewed International journal

    Takada K, Takamori S, Matsubara T, Haratake N, Akamine T, Kinoshita F, Ono Y, Wakasu S, Tanaka K, Oku Y, Oba T, Osoegawa A, Tagawa T, Takenoyama M, Shimokawa M, Oda Y, Mori M.

    PLoS One.   15 ( 11 )   e0241580   2020.11

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    DOI: doi: 10.1371/journal.pone.0241580.

  • Quantitative evaluation of liver function and pathology with hepatocyte fraction on Gadoxetic acid-enhanced MR imaging. Reviewed International journal

    Fujita N, Nishie A, Asayama Y, Ishigami K, Ushijima Y, Kakihara D, Takayama Y, Yoshizumi T, Hida T, Oda Y, Okuaki T, Honda H.

    Magn Reson Imaging.   73   125 - 129   2020.11

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    DOI: doi: 10.1016/j.mri.2020.08.018. Epub 2020 Aug 27.

  • The SWI/SNF chromatin-remodeling complex status in renal cell carcinomas with sarcomatoid or rhabdoid features. Reviewed International journal

    Kinoshita F, Kohashi K, Sugimoto M, Takamatsu D, Kiyozawa D, Eto M, Oda Y.

    Virchows Arch.   477 ( 5 )   651 - 660   2020.11

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    DOI: doi: 10.1007/s00428-020-02839-z.

  • LINE-1 hypomethylation is associated with malignant traits and cell proliferation in lung adenocarcinoma. Reviewed International journal

    Kitahara H, Okamoto T, Shimamatsu S, Kohno M, Morodomi Y, Tagawa T, Kitao H, Okano S, Oda Y, Maehara Y, Mori M.

    Anticancer Res.   40 ( 10 )   5659 - 5666   2020.10

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    DOI: doi: 10.21873/anticanres.14579.

  • Clinicopathological features and immunohistochemical utility of NTRK, ALK and ROS1-rearranged papillary thyroid carcinomas and anaplastic thyroid carcinomas. Reviewed International journal

    Nozaki Y, Yamamoto H, Iwasaki T, Sato M, Jiromaru R, Hongo T, Yasumatsu R, Oda Y.

    Hum Pathol.   106   82 - 92   2020.9

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    DOI: doi: 10.1016/j.humpath.2020.09.004.

  • Vitreous levels of interleukin-35 as a prognostic factor in B-cell vitreoretinal lymphoma. Reviewed International journal

    Sci Rep.   10 ( 1 )   15715   2020.9

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    DOI: doi: 10.1038/s41598-020-72962-z.

  • Mitochondrial expression of the DNA repair enzyme OGG1 improves the prognosis of pancreatic ductal adenocarcinoma. Reviewed International journal

    Pancreatology.   20 ( 6 )   1175 - 1182   2020.9

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    DOI: doi: 10.1016/j.pan.2020.07.011. Epub 2020 Jul 25.

  • Risk factors of periprosthetic infection in patients with tumor prostheses following resection for musculoskeletal tumor of the lower limb. Reviewed International journal

    J Clin Med.   9 ( 10 )   E3133   2020.9

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    DOI: doi: 10.3390/jcm9103133.

  • Prognostic impact of 8-hydroxy-deoxyguanosine and its repair enzyme 8-hydroxy-deoxyguanosine DNA glycosylase in hepatocellular carcinoma. Reviewed International journal

    Pathol Int.   70 ( 8 )   533 - 541   2020.8

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    DOI: doi: 10.1111/pin.12952.

  • Programmed death ligand 1/indoleamine 2,3-dioxygenase 1 expression and tumor-infiltrating lymphocyte status in renal cell carcinoma with sarcomatoid changes and rhabdoid features. Reviewed International journal

    Kiyozawa D, Takamatsu D, Kohashi K, Kinoshita F, Ishihara S, Toda Y, Eto M, Oda Y.

    Hum Pathol.   101   31 - 39   2020.7

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    DOI: doi: 10.1016/j.humpath.2020.04.003.

  • Association of pretransplant BK Polyomavirus antibody status with BK Polyomavirus infection after kidney transplantation: A prospective cohort pilot study of 47 transplant recipients. Reviewed International journal

    Hisadome Y, Noguchi H, Nakafusa Y, Sakihama K, Mei T, Kaku K, Okabe Y, Masutani K, Ohara Y, Ikeda K, Oda Y, Nakamura M.

    Transplant Proc.   52 ( 6 )   1762 - 1768   2020.7

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    DOI: doi: 10.1016/j.transproceed.2020.01.164.

  • Combined Evaluation of Tumor-Infiltrating CD8 + and FoxP3 + Lymphocytes Provides Accurate Prognosis in Stage IA Lung Adenocarcinoma.

    2020.6

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  • Genetic landscape of external auditory canal squamous cell carcinoma. Reviewed International journal

    Sato K, Komune N, Hongo T, Koike K, Niida A, Uchi R, Noda T, Kogo R, Matsumoto N, Yamamoto H, Masuda M, Oda Y, Mimori K, Nakagawa T.

    Cancer Sci.   111 ( 8 )   3010 - 3019   2020.6

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    DOI: doi: 10.1111/cas.14515.

  • Activation of the Akt/mammalian target of rapamycin pathway in combined hepatocellular carcinoma and cholangiocarcinoma significant correlation between p-4E-BP1 expression in cholangiocarcinoma component and prognosis Reviewed

    Yukihiko Okumura, Kenichi Kohashi, Yuki Tanaka, Masaki Kato, Yoshihiko Maehara, Yoshihiro Ogawa, Yoshinao Oda

    Virchows Archiv   2020.6

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    DOI: 10.1007/s00428-019-02741-3

  • Quantitative evaluation of the intratumoral distribution of platinum in oxaliplatin-treated rectal cancer: In situ visualization of platinum via synchrotron radiation X-ray fluorescence spectrometry.

    Koba R, Fujita H, Nishibori M, Saeki K, Nagayoshi K, Sadakari Y, Nagai S, Sekizawa O, Nitta K, Manabe T, Ueki T, Ishida T, Oda Y, Nakamura M.

    Int J Cancer.   2020.5

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  • Is remnant pancreatic cancer after pancreatic resection more frequent in early-stage pancreatic cancer than in advancedstage cancer? Reviewed International journal

    Ann Gastroenterol Surg.   4 ( 4 )   448 - 454   2020.5

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    DOI: DOI: 10.1002/ags3.12340

  • Concomitant Intraductal Papillary Mucinous Neoplasm in Pancreatic Ductal Adenocarcinoma Is an Independent Predictive Factor for the Occurrence of New Cancer in the Remnant Pancreas. Reviewed International journal

    Matsuda R, Miyasaka Y, Ohishi Y, Yamamoto T, Saeki K, Mochidome N, Abe A, Ozono K, Shindo K, Ohtsuka T, Kikutake C, Nakamura M, Oda Y.

    Ann Surg.   271 ( 5 )   941 - 948   2020.5

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    DOI: doi:10.1097/SLA.0000000000003060

  • PD-L1 and IDO1 expression and tumor-infiltrating lymphocytes in osteosarcoma patients comparative study of primary and metastatic lesions Reviewed

    Yu Toda, Kenichi Kohashi, Yuichi Yamada, Masato Yoshimoto, Shin Ishihara, Yoshihiro Ito, Takeshi Iwasaki, Hidetaka Yamamoto, Yoshihiro Matsumoto, Yasuharu Nakashima, Masaaki Mawatari, Yoshinao Oda

    Journal of Cancer Research and Clinical Oncology   2020.5

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    DOI: 10.1007/s00432-020-03242-6

  • Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype Reviewed

    Kazuki Takada, Gouji Toyokawa, Fumihiko Kinoshita, Tomoko Jogo, Kenichi Kohashi, Sho Wakasu, Yuki Ono, Kensuke Tanaka, Taro Oba, Atsushi Osoegawa, Tetsuzo Tagawa, Koichi Azuma, Isamu Okamoto, Mototsugu Shimokawa, Yoshinao Oda, Masaki Mori

    Journal of Cancer Research and Clinical Oncology   2020.5

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    DOI: 10.1007/s00432-020-03250-6

  • Quantification of intratumoral collagen and elastin fibers within hepatocellular carcinoma tissues finds correlations with clinico-patho-radiological features Reviewed

    Junki Maehara, Yohei Masugi, Tokiya Abe, Hanako Tsujikawa, Yutaka Kurebayashi, Akihisa Ueno, Hidenori Ojima, Shigeo Okuda, Masahiro Jinzaki, Masahiro Shinoda, Yuko Kitagawa, Yoshinao Oda, Hiroshi Honda, Michiie Sakamoto

    Hepatology Research   50 ( 5 )   607 - 619   2020.5

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    DOI: 10.1111/hepr.13484

  • OX40 and LAG3 are associated with better prognosis in advanced gastric cancer patients treated with anti-programmed death-1 antibody Reviewed

    Hirofumi Ohmura, Kyoko Yamaguchi, Fumiyasu Hanamura, Mamoru Ito, Akitaka Makiyama, Keita Uchino, Hozumi Shimokawa, Shingo Tamura, Taito Esaki, Kenji Mitsugi, Yoshihiro Shibata, Hisanobu Oda, Kenji Tsuchihashi, Hiroshi Ariyama, Hitoshi Kusaba, Yoshinao Oda, Koichi Akashi, Eishi Baba

    British journal of cancer   122 ( 10 )   1507 - 1517   2020.5

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    DOI: 10.1038/s41416-020-0810-1

  • Activation of TLR4 signaling inhibits progression of osteosarcoma by stimulating CD8-positive cytotoxic lymphocytes Reviewed

    Kenichiro Yahiro, Yoshihiro Matsumoto, Hisakata Yamada, Makoto Endo, Nokitaka Setsu, Toshifumi Fujiwara, Makoto Nakagawa, Atsushi Kimura, Eijiro Shimada, Seiji Okada, Yoshinao Oda, Yasuharu Nakashima

    Cancer Immunology, Immunotherapy   69 ( 5 )   745 - 758   2020.5

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    DOI: 10.1007/s00262-020-02508-9

  • Serum markers associated with treatment response and survival in non-small cell lung cancer patients treated with anti-PD-1 therapy Reviewed

    Kazuki Takada, Shinkichi Takamori, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto, Mototsugu Shimokawa, Taro Oba, Atsushi Osoegawa, Tetsuzo Tagawa, Mitsuhiro Takenoyama, Yoshinao Oda, Yoichi Nakanishi, Masaki Mori

    Lung Cancer   145   18 - 26   2020.5

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    DOI: 10.1016/j.lungcan.2020.04.034

  • Microsatellite instability in Japanese female patients with triple-negative breast cancer Reviewed

    Kanako Kurata, Makoto Kubo, Masaya Kai, Hitomi Mori, Hitomi Kawaji, Kazuhisa Kaneshiro, Mai Yamada, Reiki Nishimura, Tomofumi Osako, Nobuyuki Arima, Masayuki Okido, Yoshinao Oda, Masafumi Nakamura

    Breast Cancer   2020.5

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    DOI: 10.1007/s12282-019-01043-5

  • Clinical impact of skeletal muscle area in patients with non-small cell lung cancer treated with anti-PD-1 inhibitors Reviewed

    Kazuki Takada, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto, Mototsugu Shimokawa, Sho Wakasu, Shinkichi Takamori, Gouji Toyokawa, Taro Oba, Atsushi Osoegawa, Tetsuzo Tagawa, Yoshinao Oda, Yoichi Nakanishi, Masaki Mori

    Journal of Cancer Research and Clinical Oncology   2020.5

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    DOI: 10.1007/s00432-020-03146-5

  • Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10-year experience of a single institute.

    Kodama K, Sonoda K, Kijima M, Yamaguchi S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Yahata H, Ohishi Y, Oda Y, Kato K.

    Asia Pac J Clin Oncol.   2020.4

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  • Re-evaluation of preoperative endometrial smears for the cytodiagnosis of uterine leiomyosarcoma. Reviewed International journal

    Sonoda K, Nogami M, Kodama K, Oda Y, Kato K.

    Eur J Gynaecol Oncol.   41 ( 2 )   167 - 170   2020.4

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  • Retroperitoneal Myxofibrosarcoma A Controversial Entity Reviewed

    Masato Yoshimoto, Yuichi Yamada, Shin Ishihara, Kenichi Kohashi, Yu Toda, Yoshihiro Ito, Yosuke Susuki, Izumi Kinoshita, Hidetaka Yamamoto, Yasuharu Nakashima, Yoshinao Oda

    Pathology Research and Practice   2020.4

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    DOI: 10.1016/j.prp.2020.152969

  • Natural history and clinical outcomes of pancreatic neuroendocrine neoplasms based on the WHO 2017 classification; a single-center experience of 30 years Reviewed

    Nao Fujimori, Masami Miki, Lingaku Lee, Kazuhide Matsumoto, Yu Takamatsu, Takehiro Takaoka, Katsuhito Teramatsu, Yuta Suehiro, Masatoshi Murakami, Hisato Igarashi, Takamasa Oono, Takao Ohtsuka, Masafumi Nakamura, Yutaka Koga, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa

    Pancreatology   2020.4

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    DOI: 10.1016/j.pan.2020.04.003

  • High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities Reviewed

    Youran Zou, Gulisa Turashvili, Robert A. Soslow, Kay J. Park, Sabrina Croce, W. Glenn McCluggage, Colin J.R. Stewart, Yoshinao Oda, Esther Oliva, Robert H. Young, Arnaud Da Cruz Paula, Kimberly Dessources, Charles W. Ashley, Martee L. Hensley, Stephen Yip, Britta Weigelt, Ryma Benayed, Cristina R. Antonescu, Cheng Han Lee, Sarah Chiang

    Modern Pathology   2020.4

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    DOI: 10.1038/s41379-020-0535-y

  • Diagnostic utility of pan-Trk immunohistochemistry for inflammatory myofibroblastic tumours Reviewed

    Hidetaka Yamamoto, Yui Nozaki, Kenichi Kohashi, Izumi Kinoshita, Yoshinao Oda

    Histopathology   76 ( 5 )   774 - 778   2020.4

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    DOI: 10.1111/his.14010

  • HPV-related Sinonasal Carcinoma: Clinicopathologic Features, Diagnostic Utility of p16 and Rb Immunohistochemistry, and EGFR Copy Number Alteration.

    Jiromaru R, Yamamoto H, Yasumatsu R, Hongo T, Nozaki Y, Hashimoto K, Taguchi K, Masuda M, Nakagawa T, Oda Y.

    Am J Surg Pathol.   2020.3

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  • Immunohistochemical BRAF V600E Expression and Intratumor BRAF V600E Heterogeneity in Acral Melanoma: Implication in Melanoma-Specific Survival. Reviewed International journal

    Ito T, Kaku-Ito Y, Murata M, Furue K, Shen C, Oda Y, Furue M.

    J Clin Med.   2020.3

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  • A model study for the manufacture and validation of clinical-grade deciduous dental pulp stem cells for chronic liver fibrosis treatment Reviewed

    Tsuyoshi Iwanaka, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Shouichi Ohga, Yoshinao Oda, Tomoaki Taguchi

    Stem Cell Research and Therapy   11 ( 1 )   2020.3

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    DOI: 10.1186/s13287-020-01630-w

  • Solid-type poorly differentiated adenocarcinoma of the stomach Deficiency of mismatch repair and SWI/SNF complex Reviewed

    Shinichi Tsuruta, Kenichi Kohashi, Yuichi Yamada, Minako Fujiwara, Yutaka Koga, Eikichi Ihara, Yoshihiro Ogawa, Eiji Oki, Masafumi Nakamura, Yoshinao Oda

    Cancer Science   111 ( 3 )   1008 - 1019   2020.3

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    DOI: 10.1111/cas.14301

  • Sclerosing epithelioid mesenchymal neoplasm of the pancreas - a proposed new entity.

    Mod Pathol.   2020.3

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  • Colorectal diffuse large B-cell lymphoma: molecular subclassification and prognostic significance of immunoglobulin gene translocation.

    Hori Y, Yamamoto H, Nozaki Y, Torisu T, Fujiwara M, Taguchi K, Nishiyama K, Nakamura S, Kitazono T, Oda Y.

    Hum Pathol.   2020.2

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  • Establishment and characterization of a novel primitive yolk sac tumour cell line, TC587. Reviewed International journal

    Iwasaki T, Kohashi K, Ohno M, Taguchi T, Oda Y.

    Anticancer Res.   40 ( 2 )   759 - 766   2020.2

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  • Impact of Immune Response on Outcomes in Hepatocellular Carcinoma: Association With Vascular Formation. Reviewed International journal

    Itoh S, Yoshizumi T, Yugawa K, Imai D, Yoshiya S, Takeishi K, Toshima T, Harada N, Ikegami T, Soejima Y, Kohashi K, Oda Y, Mori M.

    Hepatology.   2020.2

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  • Helper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancer Reviewed

    Kyoko Yamaguchi, Mamoru Ito, Hirofumi Ohmura, Fumiyasu Hanamura, Michitaka Nakano, Kenji Tsuchihashi, Shuntaro Nagai, Hiroshi Ariyama, Hitoshi Kusaba, Hidetaka Yamamoto, Yoshinao Oda, Masafumi Nakamura, Koichi Akashi, Eishi Baba

    OncoImmunology   9 ( 1 )   2020.2

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    DOI: 10.1080/2162402X.2020.1724763

  • Association of glucose tolerance status with pancreatic β- and α-cell mass in community-based autopsy samples of Japanese individuals The Hisayama Study Reviewed

    2020.2

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    Aims/Introduction: Changes in histologically quantified β- and α-cell mass during the development of glucose intolerance have not been fully elucidated. The aim of the present study was to explore differences in β- and α-cell mass according to the glucose tolerance status. Materials and Methods: Autopsy samples from a total of 103 individuals (40 with normal glucose tolerance, 31 with prediabetes and 32 with type 2 diabetes mellitus) who underwent a 75-g oral glucose tolerance test within 5 years before death were selected from 643 community-based autopsy samples collected from 2002 to 2016. Fractional β-cell area (BCA) and α-cell area were quantified with Image Pro Plus software. Associations of BCA and α-cell area with glucose tolerance status were assessed using a linear regression analysis, and Spearman’s correlation coefficients between glycemic markers and β-cell function were estimated. Results: The mean values of BCA decreased significantly with worsening glucose tolerance status (mean ± standard error 1.85 ± 0.10% in normal glucose tolerance, 1.59 ± 0.11% in prediabetes and 1.17 ± 0.11% in type 2 diabetes mellitus, P for trend < 0.001), whereas there was no significant association between α-cell area and glucose tolerance status. BCA was inversely correlated with fasting and 2-h plasma glucose levels during oral glucose tolerance test and glycated hemoglobin measurement, and positively correlated with disposition index (all P < 0.01). Conclusions: β-Cell mass decreased significantly with worsening glucose tolerance, from the stage of prediabetes, in the Japanese population. Prevention of declining β-cell mass before the onset of glucose intolerance is important to reduce the burden of type 2 diabetes mellitus.

    DOI: 10.1111/jdi.13232

  • FAM115C could be a novel tumor suppressor associated with prolonged survival in pancreatic cancer patients Reviewed

    Kiyoshi Saeki, Hideya Onishi, Satoko Koga, Shu Ichimiya, Kazunori Nakayama, Yasuhiro Oyama, Makoto Kawamoto, Kukiko Sakihama, Takeo Yamamoto, Ryota Matsuda, Yoshihiro Miyasaka, Masafumi Nakamura, Yoshinao Oda

    Journal of Cancer   11 ( 8 )   2289 - 2302   2020.2

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    DOI: 10.7150/jca.38399

  • Automated approach for estimation of grade groups for prostate cancer based on histological image feature analysis Reviewed

    Alamgir Hossain, Hidetaka Arimura, Fumio Kinoshita, Kenta Ninomiya, Sumiko Watanabe, Kenjiro Imada, Ryoma Koyanagi, Yoshinao Oda

    Prostate   80 ( 3 )   291 - 302   2020.2

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    DOI: 10.1002/pros.23943

  • Comparative Study of Myxofibrosarcoma With Undifferentiated Pleomorphic Sarcoma: Histopathologic and Clinicopathologic Review.

    Yoshimoto M, Yamada Y, Ishihara S, Kohashi K, Toda Y, Ito Y, Yamamoto H, Furue M, Nakashima Y, Oda Y.

    2020.1

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  • Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5 Reviewed

    Yohei Ando, Kenoki Ohuchida, Yoshiki Otsubo, Shin Kibe, Shin Takesue, Toshiya Abe, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Yoshinao Oda, Masafumi Nakamura

    PloS one   15 ( 1 )   2020.1

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    DOI: 10.1371/journal.pone.0228015

  • Survival and ocular preservation in a long-term cohort of Japanese patients with retinoblastoma Reviewed

    Tamaki Ueda, Yuhki Koga, Hiroshi Yoshikawa, Mika Tanabe, Kanako Yamana, Utako Oba, Kentaro Nakashima, Hiroaki Ono, Takuya Ichimura, Shunji Hasegawa, Wakako Kato, Tetsuko Kobayashi, Hideki Nakayama, Yasunari Sakai, Tadamasa Yoshitake, Saiji Ohga, Yoshinao Oda, Shigenobu Suzuki, Koh Hei Sonoda, Shouichi Ohga

    BMC Pediatrics   20 ( 1 )   2020.1

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    DOI: 10.1186/s12887-020-1923-7

  • Methylation of drug resistance-related genes in chemotherapy-sensitive Epstein-Barr virus-associated gastric cancer.

    Ohmura H, Ito M, Uchino K, Okada C, Tanishima S, Yamada Y, Momosaki S, Komoda M, Kuwayama M, Yamaguchi K, Okumura Y, Nakano M, Tsuchihashi K, Isobe T, Ariyama H, Kusaba H, Oda Y, Akashi K, Baba E.

    FEBS Open Bio.   2020.1

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  • Non-transmissible MV Vector with Segmented RNA Genome Establishes Different Types of iPSCs from Hematopoietic Cells.

    Hiramoto T, Tahara M, Liao J, Soda Y, Miura Y, Kurita R, Hamana H, Inoue K, Kohara H, Miyamoto S, Hijikata Y, Okano S, Yamaguchi Y, Oda Y, Ichiyanagi K, Toh H, Sasaki H, Kishi H, Ryo A, Muraguchi A, Takeda M, Tani K.

    Mol Ther.   2020.1

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  • Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations Reviewed

    Yusuke Tsuda, Makoto Hirata, Kotoe Katayama, Toru Motoi, Daisuke Matsubara, Yoshinao Oda, Masashi Fujita, Hiroshi Kobayashi, Hirotaka Kawano, Yoshihiro Nishida, Tomohisa Sakai, Tomotake Okuma, Takahiro Goto, Koichi Ogura, Akira Kawai, Keisuke Ae, Ukei Anazawa, Yoshiyuki Suehara, Shintaro Iwata, Satoru Miyano, Seiya Imoto, Tatsuhiro Shibata, Hidewaki Nakagawa, Rui Yamaguchi, Sakae Tanaka, Koichi Matsuda

    International Journal of Cancer   145 ( 12 )   3276 - 3284   2019.12

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    DOI: 10.1002/ijc.32421

  • Spread through air spaces in lung neuroendocrine tumor Reviewed

    Yuka Kozuma, Gouji Toyokawa, Yuichi Yamada, Fumihiro Shoji, Koji Yamazaki, Yoshinao Oda, Sadanori Takeo

    Translational Lung Cancer Research   8   S439 - S442   2019.12

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    DOI: 10.21037/tlcr.2019.10.20

  • Uptake of 18F-FDG in Adrenal Adenomas Is Associated With Unenhanced CT Value and Constituent Cells Reviewed

    Ryo Murayama, Akihiro Nishie, Tomoyuki Hida, Shingo Baba, Junichi Inokuchi, Yoshinao Oda, Hiroshi Honda

    Clinical nuclear medicine   44 ( 12 )   943 - 948   2019.12

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    DOI: 10.1097/RLU.0000000000002759

  • Intra-and inter-tumor braf heterogeneity in acral melanoma An immunohistochemical analysis Reviewed

    Takamichi Ito, Yumiko Kaku-Ito, Maho Murata, Toshio Ichiki, Yuki Kuma, Yuka Tanaka, Taketoshi Ide, Fumitaka Ohno, Maiko Wada-Ohno, Yuichi Yamada, Yoshinao Oda, Masutaka Furue

    International journal of molecular sciences   20 ( 24 )   2019.12

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    DOI: 10.3390/ijms20246191

  • The balance of forces generated by kinesins controls spindle polarity and chromosomal heterogeneity in tetraploid cells.

    Shu S, Iimori M, Wakasa T, Ando K, Saeki H, Oda Y, Oki E, Maehara Y

    J Cell Sci.   2019.12

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  • Integrated exome and RNA sequencing of dedifferentiated liposarcoma.

    Hirata M, Asano N, Katayama K, Yoshida A, Tsuda Y, Sekimizu M, Mitani S, Kobayashi E, Komiyama M, Fujimoto H, Goto T, Iwamoto Y, Naka N, Iwata S, Nishida Y, Hiruma T, Hiraga H, Kawano H, Motoi T, Oda Y, Matsubara D, Fujita M, Shibata T, Nakagawa H, Nakayama R, Kondo T, Imoto S, Miyano S, Kawai A, Yamaguchi R, Ichikawa H, Matsuda K.

    Nat Commun   2019.12

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  • The Altered Mucosal Barrier Function in the Duodenum Plays a Role in the Pathogenesis of Functional Dyspepsia. Reviewed International journal

    Komori K, Ihara E, Minoda Y, Ogino H, Sasaki T, Fujiwara M, Oda Y, Ogawa Y.

    Dig Dis Sci.   2019.11

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  • Detection of Hepatitis Virus B And C in Archival Autopsy Specimens of Liver Cirrhosis. Reviewed International journal

    Tsutsumi Y, Shiogama K, Teramoto H, Aishima S, Oda Y, Ohashi R, Ajioka Y, Naito M.

    Biomed J Sci &Tech Res.   2019.11

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  • Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma. Reviewed International journal

    Mano Y, Yoshio S, Shoji H, Tomonari S, Aoki Y, Aoyanagi N, Okamoto T, Matsuura Y, Osawa Y, Kimura K, Yugawa K, Wang H, Oda Y, Yoshizumi T, Maehara Y, Kanto T.

    J Gastroenterol.   2019.11

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  • Clinicopathological review of solitary fibrous tumors dedifferentiation is a major cause of patient death Reviewed

    Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Itou, Yutaka Koga, Mikiko Hashisako, Yui Nozaki, Daisuke Kiyozawa, Daichi Kitahara, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Yoshifumi Matsushita, Fumiyoshi Fushimi, Kenichi Taguchi, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda

    Virchows Archiv   475 ( 4 )   467 - 477   2019.10

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    DOI: 10.1007/s00428-019-02622-9

  • Reduced Estimated GFR and Cardiac Remodeling A Population-Based Autopsy Study Reviewed

    Kensuke Izumaru, Jun Hata, Toshiaki Nakano, Yutaka Nakashima, Masaharu Nagata, Masayo Fukuhara, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya

    American Journal of Kidney Diseases   74 ( 3 )   373 - 381   2019.9

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    DOI: 10.1053/j.ajkd.2019.02.013

  • 18F-FDG uptake in PET/CT is a potential predictive biomarker of response to anti-PD-1 antibody therapy in non-small cell lung cancer.

    Takada K, Toyokawa G, Yoneshima Y, Tanaka K, Okamoto I, Shimokawa M, Wakasu S, Haro A, Osoegawa A, Tagawa T, Oda Y, Nakanishi Y, Mori M.

    Sci Rep.   2019.9

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  • Spread through air spaces in non-small cell lung cancer.

    Kozuma Y, Toyokawa G, Yamada Y, Shoji F, Yamazaki K, Oda Y, Takeo S

    2019.9

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  • IFN-γ Promotes Epithelial-Mesenchymal Transition and the Expression of PD-L1 in Pancreatic Cancer Reviewed

    240   115 - 123   2019.8

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    Background: Tumor immune reactions not only provide host defense but also accelerate tumor immune escape and phenotype switching. Here, we examined the association of programmed cell death ligand 1 (PD-L1) expression with epithelial-mesenchymal transition (EMT)–associated markers in pancreatic ductal adenocarcinoma (PDA) within the context of the tumor microenvironment. Materials and methods: PDA samples from 36 patients were analyzed for PD-L1, vimentin, E-cadherin, and Snail expressions and for PDA cell and immune cell infiltration. PD-L1 expression and EMT in PDA cell lines under conditions of altering interferon gamma (IFN-γ) signals were also assessed. Results: Immunohistochemistry revealed a significant correlation between vimentin and PD-L1 expression, whereas double staining showed them to be simultaneously expressed by PDA cells. Positive vimentin expression was associated with the infiltration of a lower number of CD8 + T cells and a higher number of FoxP3 + cells and poor patient prognosis (P = 0.03). PDA tumor cells promoted PD-L1 expression and EMT under the presence of IFN-γ which was inhibited by the signal transducer and activator of transcription (STAT)1 small interfering RNA. Conclusions: Strong correlations were observed between PD-L1 expression, EMT, and the immunosuppressive tumor microenvironment. Targeting STAT1 combined with PD-1/PD-L1 immunotherapy may improve outcomes for patients with PDA.

    DOI: 10.1016/j.jss.2019.02.038

  • T-bet+ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer Reviewed

    Hitomi Mori, Makoto Kubo, Masaya Kai, Mai Yamada, Kanako Kurata, Hitomi Kawaji, Kazuhisa Kaneshiro, Tomofumi Osako, Reiki Nishimura, Nobuyuki Arima, Masayuki Okido, Junji Kishimoto, Yoshinao Oda, Masafumi Nakamura

    Breast Cancer Research and Treatment   176 ( 3 )   569 - 577   2019.8

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    DOI: 10.1007/s10549-019-05256-2

  • Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body Reviewed

    Xiaopeng Bai, Eikichi Ihara, Yoshihihro Otsuka, Shinichi Tsuruta, Katsuya Hirano, Yoshimasa Tanaka, Haruei Ogino, Mayumi Hirano, Takatoshi Chinen, Hirotada Akiho, Kazuhiko Nakamura, Yoshinao Oda, Yoshihiro Ogawa

    European Journal of Pharmacology   857   2019.8

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    DOI: 10.1016/j.ejphar.2019.172405

  • CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors Reviewed

    Masami Miki, Takamasa Oono, Nao Fujimori, Takehiro Takaoka, Ken Kawabe, Yoshihiro Miyasaka, Takao Ohtsuka, Daisuke Saito, Masafumi Nakamura, Yasuyuki Ohkawa, Yoshinao Oda, Mikita Suyama, Tetsuhide Ito, Yoshihiro Ogawa

    Cancer Medicine   8 ( 8 )   3748 - 3760   2019.7

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    DOI: 10.1002/cam4.2232

  • Mucosal incision assisted biopsy vs. endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions: A randomized crossover study. Reviewed International journal

    Osoegawa T, Minoda Y, Ihara E, Komori K, Aso A, Goto A, Itaba S, Ogino H, Nakamura K, Harada N, Makihara K, Tsuruta S, Yamamoto H, Ogawa Y.

    Dig Endosc.   2019.7

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  • Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma. Reviewed International journal

    Nakamura S, Sadakari Y, Ohtsuka T, Okayama T, Nakashima Y, Gotoh Y, Saeki K, Mori Y, Nakata K, Miyasaka Y, Onishi H, Oda Y, Goggins M, Nakamura M.

    Ann Surg Oncol.   2019.7

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  • Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot.

    Yamamura K, Sakamoto I, Morihana E, Hirata Y, Nagata H, Yamasaki Y, Okumura Y, Kohashi K, Koto K, Tsutsui H, Ohga S.

    Int J Cardiol.   2019.7

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  • A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma Reviewed

    Taichi Matsubara, Kazuki Takada, Koichi Azuma, Shinkichi Takamori, Gouji Toyokawa, Akira Haro, Atsushi Osoegawa, Tetsuzo Tagawa, Akihiko Kawahara, Jun Akiba, Isamu Okamoto, Yoichi Nakanishi, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara

    Annals of Surgical Oncology   26 ( 6 )   1925 - 1933   2019.6

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    DOI: 10.1245/s10434-019-07257-3

  • Clinicopathological features and phenotypic classification of de novo-type colorectal carcinomas differ from those of colorectal carcinomas derived from flat adenomas.

    Koga Y, Hirahashi M, Ohishi Y, Oda Y.

    Pathol Int.   2019.6

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  • Gastric hepatoid adenocarcinomas are a genetically heterogenous group; most tumors show chromosomal instability, but MSI tumors do exist Reviewed

    Shinichi Tsuruta, Yoshihiro Ohishi, Minako Fujiwara, Eikichi Ihara, Yoshihiro Ogawa, Eiji Oki, Masafumi Nakamura, Yoshinao Oda

    Human Pathology   88   27 - 38   2019.6

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    DOI: 10.1016/j.humpath.2019.03.006

  • Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma Reviewed

    Kazuki Takada, Mototsugu Shimokawa, Kensuke Tanaka, Kenichi Kohashi, Akira Haro, Atsushi Osoegawa, Tetsuzo Tagawa, Koichi Azuma, Isamu Okamoto, Yoshinao Oda, Masaki Mori

    PloS one   14 ( 6 )   2019.6

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    DOI: 10.1371/journal.pone.0217991

  • CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis Reviewed

    Zilong Yan, Kenoki Ohuchida, Biao Zheng, Takashi Okumura, Shin Takesue, Hiromichi Nakayama, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura

    Journal of Cancer Research and Clinical Oncology   145 ( 5 )   1147 - 1164   2019.5

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    DOI: 10.1007/s00432-019-02860-z

  • The Significance of CD44 Variant 9 in Resected Lung Adenocarcinoma Correlation with Pathological Early-Stage and EGFR Mutation Reviewed

    Takaki Akamine, Tetsuzo Tagawa, Kayo Ijichi, Gouji Toyokawa, Shinkichi Takamori, Fumihiko Hirai, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Annals of Surgical Oncology   26 ( 5 )   1544 - 1551   2019.5

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    DOI: 10.1245/s10434-018-07137-2

  • Navigation surgery using indocyanine green fluorescent imaging for hepatoblastoma patients Reviewed

    Ryota Souzaki, Naonori Kawakubo, Toshiharu Matsuura, Koichiro Yoshimaru, Yuhki Koga, Junkichi Takemoto, Yuichi Shibui, Kenichi Kohashi, Makoto Hayashida, Yoshinao Oda, Shouichi Ohga, Tomoaki Taguchi

    Pediatric surgery international   35 ( 5 )   551 - 557   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00383-019-04458-5

  • Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens Reviewed

    Shinji Kohsaka, Kenji Tatsuno, Toshihide Ueno, Masaaki Nagano, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Daiya Takai, Masachika Ikegami, Hiroshi Kobayashi, Hidenori Kage, Mizuo Ando, Keisuke Hata, Hiroki Ueda, Shogo Yamamoto, Shinya Kojima, Kumiko Oseto, Keisuke Akaike, Yoshiyuki Suehara, Takuo Hayashi, Tsuyoshi Saito, Fumiyuki Takahashi, Kazuhisa Takahashi, Kazuya Takamochi, Kenji Suzuki, Satoshi Nagayama, Yoshinao Oda, Koshi Mimori, Soichiro Ishihara, Yutaka Yatomi, Takahide Nagase, Jun Nakajima, Sakae Tanaka, Masashi Fukayama, Katsutoshi Oda, Masaomi Nangaku, Kohei Miyazono, Kiyoshi Miyagawa, Hiroyuki Aburatani, Hiroyuki Mano

    Cancer Science   110 ( 4 )   1464 - 1479   2019.4

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    DOI: 10.1111/cas.13968

  • Highly expressed EZH2 in combination with BAP1 and MTAP loss, as detected by immunohistochemistry, is useful for differentiating malignant pleural mesothelioma from reactive mesothelial hyperplasia Reviewed

    Masayo Yoshimura, Yoshiaki Kinoshita, Makoto Hamasaki, Shinji Matsumoto, Tomoyuki Hida, Yoshinao Oda, Akinori Iwasaki, Kazuki Nabeshima

    Lung Cancer   130   187 - 193   2019.4

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    DOI: 10.1016/j.lungcan.2019.02.004

  • Genetic assessment of recurrent pancreatic high-risk lesions in the remnant pancreas Metachronous multifocal lesion or local recurrence? Reviewed

    Yoshitaka Gotoh, Takao Ohtsuka, So Nakamura, Koji Shindo, Kenoki Ohuchida, Yoshihiro Miyasaka, Yasuhisa Mori, Naoki Mochidome, Yoshinao Oda, Masafumi Nakamura

    Surgery (United States)   165 ( 4 )   767 - 774   2019.4

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    DOI: 10.1016/j.surg.2018.10.025

  • Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix Reviewed

    Takashi Okumura, Kenoki Ouchida, Shin Kibe, Chika Iwamoto, Yohei Ando, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Masafumi Sada, Kohei Horioka, Naoki Mochidome, Makoto Arita, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Ohtsuka Takao, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura

    International Journal of Cancer   144 ( 6 )   1401 - 1413   2019.3

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    DOI: 10.1002/ijc.31775

  • A novel prognostic marker in patients with non-small cell lung cancer: musculo-immuno-nutritional score calculated by controlling nutritional status and creatine kinase. Reviewed International journal

    Takamori S, Toyokawa G, Shimokawa M, Kinoshita F, Kozuma Y, Matsubara T, Haratake N, Akamine T, Hirai F, Tagawa T, Oda Y, Maehara Y.

    J Thorac Dis.   2019.3

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  • Positive correlation between the density of macrophages and T-cells in undifferentiated sarcoma. Reviewed International journal

    Komohara Y, Takeya H, Wakigami N, Kusada N, Bekki H, Ishihara S, Takeya M, Nakashima Y, Oda Y.

    Med Mol Morphol.   2019.3

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  • Wnt/β-catenin signaling, which is activated in odontomas, reduces Sema3A expression to regulate odontogenic epithelial cell proliferation and tooth germ development Reviewed

    9 ( 1 )   2019.3

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    Odontomas, developmental anomalies of tooth germ, frequently occur in familial adenomatous polyposis patients with activated Wnt/β-catenin signaling. However, roles of Wnt/β-catenin signaling in odontomas or odontogenic cells are unclear. Herein, we investigated β-catenin expression in odontomas and functions of Wnt/β-catenin signaling in tooth germ development. β-catenin frequently accumulated in nucleus and/or cellular cytoplasm of odontogenic epithelial cells in human odontoma specimens, immunohistochemically. Wnt/β-catenin signaling inhibited odontogenic epithelial cell proliferation in both cell line and tooth germ development, while inducing immature epithelial bud formation. We identified Semaphorin 3A (Sema3A) as a downstream molecule of Wnt/β-catenin signaling and showed that Wnt/β-catenin signaling-dependent reduction of Sema3A expression resulted in suppressed odontogenic epithelial cell proliferation. Sema3A expression is required in appropriate epithelial budding morphogenesis. These results suggest that Wnt/β-catenin signaling negatively regulates odontogenic epithelial cell proliferation and tooth germ development through decreased-Sema3A expression, and aberrant activation of Wnt/β-catenin signaling may associate with odontoma formation.

    DOI: 10.1038/s41598-019-39686-1

  • Short- and long-term outcomes of surgical treatment for remnant gastric cancer after distal gastrectomy Reviewed

    Yu Nakaji, Hiroshi Saeki, Kensuke Kudou, Ryota Nakanishi, Masahiko Sugiyama, Yuichiro Nakashima, Kouji Andou, Yoshinao Oda, Eiji Oki, Yoshihiko Maehara

    Anticancer research   39 ( 3 )   1411 - 1415   2019.3

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    DOI: 10.21873/anticanres.13256

  • Posttransplant recipient-derived CD4 + T-cell lymphoproliferative disease in X-linked hyper-IgM syndrome Reviewed

    Yasuaki Hagio, Akira Shiraishi, masataka ishimura, Motoshi Sonoda, Katsuhide Eguchi, Hidetaka Yamamoto, Yoshinao Oda, Shoichi Ohga

    Pediatric Blood and Cancer   66 ( 3 )   2019.3

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    DOI: 10.1002/pbc.27529

  • HuC/D expression in small round cell tumors and neuroendocrine tumors a useful tool for distinguishing neuroblastoma from childhood small round cell tumors Reviewed

    Junkichi Takemoto, Masaaki Kuda, Kenichi Kouhashi, Yuichi Yamada, Yutaka Koga, Izumi Kinoshita, Ryota Sozaki, Tomoaki Taguchi, Yoshinao Oda

    Human Pathology   85   162 - 167   2019.3

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    DOI: 10.1016/j.humpath.2018.11.004

  • Glypican-3 expression in malignant small round cell tumors Reviewed

    Yuichi Shibui, Kina Miyoshi, Kenichi Kouhashi, Yoshiaki Kinoshita, Masaaki Kuda, Hidetaka Yamamoto, Tomoaki Taguchi, Yoshinao Oda

    Oncology Letters   17 ( 3 )   3523 - 3528   2019.3

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    DOI: 10.3892/ol.2019.9976

  • Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion Reviewed

    Shin Kibe, Kenoki Ouchida, Yohei Ando, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Takashi Okumura, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Masaya Shimamoto, Ohtsuka Takao, Kazuhiro Mizumoto, Yoshinao Oda, Masafumi Nakamura

    Cancer Letters   444   70 - 81   2019.3

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    DOI: 10.1016/j.canlet.2018.12.005

  • A Positive Correlation Between the EZH2 and PD-L1 Expression in Resected Lung Adenocarcinomas Reviewed

    Gouji Toyokawa, Kazuki Takada, Tetsuzo Tagawa, Ryuji Hamamoto, Yuichi Yamada, Mototsugu Shimokawa, Yoshinao Oda, Yoshihiko Maehara

    Annals of Thoracic Surgery   107 ( 2 )   393 - 400   2019.2

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    DOI: 10.1016/j.athoracsur.2018.08.056

  • Acquired isolated hypoganglionosis as a distinct entity: results from a nationwide survey. Reviewed International journal

    Obata S, Yoshimaru K, Kirino K, Izaki T, Ieiri S, Yamataka A, Koshinaga T, Iwai J,Ikeda H, Matsufuji H, Oda Y, Taguchi T.

    Pediatr Surg Int.   2019.2

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  • Co-expression of IDO1 and PD-L1 in lung squamous cell carcinoma Potential targets of novel combination therapy Reviewed

    Kazuki Takada, Kenichi Kouhashi, Mototsugu Shimokawa, Akira Haro, Atsushi Osoegawa, Tetsuzo Tagawa, Takashi Seto, Yoshinao Oda, Yoshihiko Maehara

    Lung Cancer   128   26 - 32   2019.2

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    DOI: 10.1016/j.lungcan.2018.12.008

  • Neoadjuvant Chemotherapy with Gemcitabine Plus Nab-Paclitaxel for Borderline Resectable Pancreatic Cancer Potentially Improves Survival and Facilitates Surgery Reviewed

    Yoshihiro Miyasaka, Ohtsuka Takao, Ryuichiro Kimura, Ryota Matsuda, Yasuhisa Mori, Kohei Nakata, Daisuke Kakihara, Nao Fujimori, Takamasa Ohno, Yoshinao Oda, Masafumi Nakamura

    Annals of Surgical Oncology   2019.1

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    DOI: 10.1245/s10434-019-07309-8

  • Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors. Reviewed International journal

    Nakashima Y, Ohtsuka T, Nakamura S, Mori Y, Nakata K, Miyasaka Y, Ishigami K, Matsuda R, Oda Y, Nakamura M.

    Pancreatology.   2019.1

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  • Sclerosing epithelioid mesenchymal neoplasm of the pancreas – a proposed new entity Reviewed

    Olca Basturk, Britta Weigelt, Volkan Adsay, Jamal K. Benhamida, Gokce Askan, Lu Wang, Maria E. Arcila, Giuseppe Zamboni, Noriyoshi Fukushima, Rodrigo Gularte-Mérida, Arnaud Da Cruz Paula, Pier Selenica, Rahul Kumar, Fresia Pareja, Christopher A. Maher, John Scholes, Yoshinao Oda, Donatella Santini, Leona A. Doyle, Iver Petersen, Uta Flucke, Christian Koelsche, Samuel J. Reynolds, Aslihan Yavas, Andreas von Deimling, Jorge S. Reis-Filho, David S. Klimstra

    2019.1

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    We have encountered pancreatic tumors with unique histologic features, which do not conform to any of the known tumors of the pancreas or other anatomical sites. We aimed to define their clinicopathologic features and whether they are characterized by recurrent molecular signatures. Eight cases were identified; studied histologically and by immunohistochemistry. Selected cases were also subjected to whole-exome sequencing (WES; n = 4), RNA-sequencing (n = 6), Archer FusionPlex assay (n = 5), methylation profiling using the Illumina MethylationEPIC (850k) array platform (n = 6), and TERT promoter sequencing (n = 5). Six neoplasms occurred in females. The mean age was 43 years (range: 26–75). Five occurred in the head/neck of the pancreas. All patients were treated surgically; none received neoadjuvant/adjuvant therapy. All patients are free of disease after 53 months of median follow-up (range: 8–94). The tumors were well-circumscribed, and the median size was 1.8 cm (range: 1.3–5.8). Microscopically, the unencapsulated tumors had a geographic pattern of epithelioid cell nests alternating with spindle cell fascicles. Some areas showed dense fibrosis, in which enmeshed tumor cells imparted a slit-like pattern. The predominant epithelioid cells had scant cytoplasm and round-oval nuclei with open chromatin. The spindle cells displayed irregular, hyperchromatic nuclei. Mitoses were rare. No lymph node metastases were identified. All tumors were positive for vimentin, CD99 and cytokeratin (patchy), while negative for markers of solid pseudopapillary neoplasm, neuroendocrine, acinar, myogenic/rhabdoid, vascular, melanocytic, or lymphoid differentiation, gastrointestinal stromal tumor as well as MUC4. Whole-exome sequencing revealed no recurrent somatic mutations or amplifications/homozygous deletions in any known oncogenes or tumor suppressor genes. RNA-sequencing and the Archer FusionPlex assay did not detect any recurrent likely pathogenic gene fusions. Single sample gene set enrichment analysis revealed that these tumors display a likely mesenchymal transcriptomic program. Unsupervised analysis (t-SNE) of their methylation profiles against a set of different mesenchymal neoplasms demonstrated a distinct methylation pattern. Here, we describe pancreatic neoplasms with unique morphologic/immunophenotypic features and a distinct methylation pattern, along with a lack of abnormalities in any of key genetic drivers, supporting that these neoplasms represent a novel entity with an indolent clinical course. Given their mesenchymal transcriptomic features, we propose the designation of “sclerosing epithelioid mesenchymal neoplasm” of the pancreas.

    DOI: 10.1038/s41379-019-0334-5

  • Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma 10-year experience of a single institute Reviewed

    Keisuke Kodama, Kenzo Sonoda, Masako Kijima, Shinichiro Yamaguchi, Hiroshi Yagi, Masafumi Yasunaga, Tatsuhiro Ohgami, Ichiro Onoyama, Eisuke Kaneki, Kaoru Okugawa, Hideaki Yahata, Yoshihiro Ohishi, Yoshinao Oda, Kiyoko Kato

    Asia-Pacific Journal of Clinical Oncology   2019.1

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    DOI: 10.1111/ajco.13286

  • Quantitative evaluation of the intratumoral distribution of platinum in oxaliplatin-treated rectal cancer In situ visualization of platinum via synchrotron radiation X-ray fluorescence spectrometry Reviewed

    Ryo Koba, Hayato Fujita, Maiko Nishibori, Kiyoshi Saeki, Kinuko Nagayoshi, Yoshihiko Sadakari, Shuntaro Nagai, Oki Sekizawa, Kiyofumi Nitta, Tatsuya Manabe, Takashi Ueki, Tatsuhiro Ishida, Yoshinao Oda, Masafumi Nakamura

    International Journal of Cancer   2019.1

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    DOI: 10.1002/ijc.32592

  • Non-transmissible MV Vector with Segmented RNA Genome Establishes Different Types of iPSCs from Hematopoietic Cells Reviewed

    Takafumi Hiramoto, Maino Tahara, Jiyuan Liao, Yasushi Soda, Yoshie Miura, Ryo Kurita, Hiroshi Hamana, Kota Inoue, Hiroshi Kohara, Shohei Miyamoto, Yasuki Hijikata, Shinji Okano, Yoshiyuki Yamaguchi, Yoshinao Oda, Kenji Ichiyanagi, Hidehiro Toh, Hiroyuki Sasaki, Hiroyuki Kishi, Akihide Ryo, Atsushi Muraguchi, Makoto Takeda, Kenzaburo Tani

    Molecular Therapy   2019.1

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    DOI: 10.1016/j.ymthe.2019.09.007

  • Combined Evaluation of Tumor-Infiltrating CD8 + and FoxP3 + Lymphocytes Provides Accurate Prognosis in Stage IA Lung Adenocarcinoma Reviewed

    Fumihiko Kinoshita, Kazuki Takada, Yuichi Yamada, Yuka Oku, Keisuke Kosai, Yuki Ono, Kensuke Tanaka, Sho Wakasu, Taro Oba, Atsushi Osoegawa, Tetsuzo Tagawa, Mototsugu Shimokawa, Yoshinao Oda, Masaki Mori

    Annals of Surgical Oncology   2019.1

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    DOI: 10.1245/s10434-019-08029-9

  • Risk factors for failure of vitrectomy cell block technique in cytological diagnosis of vitreoretinal lymphoma Reviewed

    Takako Ito, Atsunobu Takeda, Kohta Fujiwara, Eiichi Hasegawa, shintaro nakao, Yoshihiro Ohishi, Yoshinao Oda, Hiroshi Yoshikawa, Kohei Sonoda

    Graefe's Archive for Clinical and Experimental Ophthalmology   2019.1

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    DOI: 10.1007/s00417-019-04266-6

  • Prognostic Impact of Programmed Death-Ligand 2 Expression in Primary Lung Adenocarcinoma Patients Reviewed

    Shinkichi Takamori, Kazuki Takada, Koichi Azuma, Tomoko Jogo, Mototsugu Shimokawa, Gouji Toyokawa, Fumihiko Hirai, Tetsuzo Tagawa, Akihiko Kawahara, Jun Akiba, Isamu Okamoto, Yoichi Nakanishi, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara

    Annals of Surgical Oncology   2019.1

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    DOI: 10.1245/s10434-019-07231-z

  • Retroperitoneal schwannoma preoperatively diagnosed as liver metastasis from colon cancer A case report Reviewed

    Huanlin Wang, Tomoharu Yoshizumi, Shinji Itoh, Toru Ikegami, Noboru Harada, Yoshinao Oda, Masaki Mori

    International Journal of Surgery Case Reports   64   31 - 34   2019

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    DOI: 10.1016/j.ijscr.2019.09.031

  • A Case of Undifferentiated Sarcoma in the Superior Vena Cava and Bilateral Cervical Veins Reviewed

    Hiroshi Kobayashi, Yuka Kobayashi, Sho Yuasa, Masayuki Okabe, Yuichi Yamada, Yoshinao Oda, Maria Debiec-Rychter, Brian P. Rubin, Toshimitsu Suzuki

    The American journal of case reports   19   1507 - 1514   2018.12

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    DOI: 10.12659/AJCR.911659

  • Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer Reviewed

    Hideaki Yahata, Hiroaki Kobayashi, Kenzo Sonoda, Keisuke Kodama, hiroshi yagi, Masafumi Yasunaga, Tatsuhiro Ogami, Ichiro Onoyama, Kaneki Eisuke, Okugawa Kaoru, Shingo Baba, Takuro Isoda, Yoshihiro Ohishi, Yoshinao Oda, Kiyoko Kato

    International Journal of Clinical Oncology   23 ( 6 )   1167 - 1172   2018.12

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    DOI: 10.1007/s10147-018-1327-y

  • Prognostic Value of Preoperative Nutritional and Immunological Factors in Patients with Pancreatic Ductal Adenocarcinoma Reviewed

    Toshiya Abe, Kohei Nakata, Shin Kibe, Yasuhisa Mori, Yoshihiro Miyasaka, Kenoki Ouchida, Ohtsuka Takao, Yoshinao Oda, Masafumi Nakamura

    Annals of Surgical Oncology   25 ( 13 )   3996 - 4003   2018.12

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    DOI: 10.1245/s10434-018-6761-6

  • Differences in PD-L1 expression on tumor and immune cells between lung metastases and corresponding primary tumors Reviewed

    Shinkichi Takamori, Kazuki Takada, Tetsuzo Tagawa, Gouji Toyokawa, Fumihiko Hirai, Nami Yamashita, Tatsuro Okamoto, Eiji Oki, Tomoharu Yoshizumi, Yoshinao Oda, Yoshihiko Maehara

    Surgical Oncology   27 ( 4 )   637 - 641   2018.12

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    DOI: 10.1016/j.suronc.2018.08.001

  • CD44v9 is associated with epithelial-mesenchymal transition and poor outcomes in esophageal squamous cell carcinoma Reviewed

    Daisuke Taniguchi, Hiroshi Saeki, Yuichiro Nakashima, Kensuke Kudou, Ryota Nakanishi, Nobuhide Kubo, Kouji Andou, Eiji Oki, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   7 ( 12 )   6258 - 6268   2018.12

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    DOI: 10.1002/cam4.1874

  • "pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma with Mucoepidermoid Carcinoma-like Features Reviewed

    Kiyoshi Saeki, Yoshihiro Ohishi, Ryota Matsuda, Naoki Mochidome, Yoshihiro Miyasaka, Hidetaka Yamamoto, Yutaka Koga, Yoshihiko Maehara, Masafumi Nakamura, Yoshinao Oda

    American Journal of Surgical Pathology   42 ( 11 )   1419 - 1428   2018.11

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    DOI: 10.1097/PAS.0000000000001135

  • Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor. Invited Reviewed International journal

    Tatsuro Abe, Kenichi Kohashi,Junkichi Takemoto, Fumio Kinoshita, Masatoshi Eto,and Yoshinao Oda

    J Cancer   2018.11

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    DOI: 10.7150/jca.25279

  • The utility of muscle-sparing axillar skin crease incision with thoracoscopic surgery in children Reviewed

    Ryota Sozaki, Naonori Kawakubo, Kina Miyoshi, Satoshi Obata, Yoshiaki Kinoshita, Junkichi Takemoto, Kenichi Kouhashi, Yoshinao Oda, Tomoaki Taguchi

    Journal of Laparoendoscopic and Advanced Surgical Techniques   28 ( 11 )   1378 - 1382   2018.11

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    DOI: 10.1089/lap.2018.0169

  • Radiotherapy for Langerhans cell histiocytosis with paraplegia A rare oncologic emergency case report in infancy and literature review Reviewed

    Kentaro Nakashima, Yuhki Koga, Yasunari Sakai, Hidetoshi Takada, Katsumi Harimaya, Ohga Saiji, Tomoaki Taguchi, Yoshinao Oda, Hiroshi Honda, Shoichi Ohga

    Brain and Development   40 ( 10 )   952 - 955   2018.11

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    DOI: 10.1016/j.braindev.2018.05.016

  • Radiological features of programmed cell death-ligand 2-positive lung adenocarcinoma A single-institution retrospective study Reviewed

    Kazuki Takada, Gouji Toyokawa, Koichi Azuma, Shinkichi Takamori, Tomoko Jogo, Fumihiko Hirai, Tetsuzo Tagawa, Akihiko Kawahara, Jun Akiba, Isamu Okamoto, Yoichi Nakanishi, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara

    In Vivo   32 ( 6 )   1541 - 1550   2018.11

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    DOI: 10.21873/invivo.11412

  • BUBR1 insufficiency is correlated with eNOS reduction experimentally in vitro and in vivo, and in gastric cancer tissue Reviewed

    Eisuke Kawakubo, Takuya Matsumoto, Keiji Yoshiya, Sho Yamashita, Tomoko Jogo, Hiroshi Saeki, Eiji Oki, Tadashi Furuyama, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   38 ( 11 )   6099 - 6106   2018.11

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    DOI: 10.21873/anticanres.12960

  • BRCAness Combined With a Family History of Cancer Is Associated With a Poor Prognosis for Breast Cancer Patients With a High Risk of BRCA Mutations Reviewed

    Hitomi Mori, Makoto Kubo, Masaya Kai, Vittoria Vanessa Velasquez, Kanako Kurata, Mai Yamada, Masayuki Okido, Syoji Kuroki, Yoshinao Oda, Masafumi Nakamura

    Clinical Breast Cancer   18 ( 5 )   e1217 - e1227   2018.10

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    DOI: 10.1016/j.clbc.2018.05.008

  • Significance of spread through air spaces in early-stage lung adenocarcinomas undergoing limited resection Reviewed

    Toyokawa G, Yamada Y, Tagawa T, Oda Y.

    Thorac Cancer.   ( 10 )   1255 - 1261   2018.10

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    DOI: doi: 10.1111/1759-7714.12828.

  • Prognostic impact of PD-L2 expression and association with PD-L1 in patients with small-cell lung cancer Reviewed

    Shinkichi Takamori, Kazuki Takada, Koichi Azuma, Yumiko Jogo, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Gouji Toyokawa, Fumihiko Hirai, Tetsuzo Tagawa, Isamu Okamoto, Yoichi Nakanishi, Akihiko Kawahara, Jun Akiba, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   38 ( 10 )   5903 - 5907   2018.10

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    DOI: 10.21873/anticanres.12934

  • PD-L2 expression as a potential predictive biomarker for the response to anti-PD-1 drugs in patients with non-small cell lung cancer Reviewed

    Shinkichi Takamori, Kazuki Takada, Gouji Toyokawa, Koichi Azuma, Mototsugu Shimokawa, Tomoko Jogo, Yuichi Yamada, Fumihiko Hirai, Tetsuzo Tagawa, Akihiko Kawahara, Jun Akiba, Isamu Okamoto, Yoichi Nakanishi, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara

    Anticancer research   38 ( 10 )   5897 - 5901   2018.10

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    DOI: 10.21873/anticanres.12933

  • Metastatic esophageal carcinosarcoma comprising neuroendocrine carcinoma, squamous cell carcinoma, and sarcoma A case report Reviewed

    Kenji Tsuchihashi, Shuji Arita, Minako Fujiwara, Kazuhide Iwasaki, Atsushi Hirano, Tomoyasu Yoshihiro, Kenta Nio, Yutaka Koga, Motohiro Esaki, hiroshi ariyama, Hitoshi Kusaba, Taiki Moriyama, Kenoki Ouchida, Eishi Nagai, Masafumi Nakamura, Yoshinao Oda, Koichi Akashi, Eishi Baba

    Medicine (United States)   97 ( 41 )   2018.10

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    DOI: 10.1097/MD.0000000000012796

  • Computed tomography features of resected lung adenocarcinomas with spread through air spaces Reviewed

    Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Takeshi Kamitani, Yuzo Yamasaki, Mototsugu Shimokawa, Yoshinao Oda, Yoshihiko Maehara

    Journal of Thoracic and Cardiovascular Surgery   156 ( 4 )   1670 - 1676.e4   2018.10

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    DOI: 10.1016/j.jtcvs.2018.04.126

  • CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication a comparison with its counterparts in the kidney and soft tissue Reviewed

    Yuka Yoshida, Sumihito Nobusawa, Satoshi Nakata, Mitsutoshi Nakada, Yoshiki Arakawa, Yohei Mineharu, Yasuo Sugita, Takako Yoshioka, Asuka Araki, Yuichiro Sato, Hideo Takeshima, Masahiko Okada, Akira Nishi, Tatsuya Yamazaki, Kenichi Kouhashi, Yoshinao Oda, Junko Hirato, Hideaki Yokoo

    Brain Pathology   28 ( 5 )   710 - 720   2018.9

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    DOI: 10.1111/bpa.12585

  • Tumor-induced osteomalacia caused by a massive phosphaturic mesenchymal tumor of the acetabulum A case report Reviewed

    Kimitaka Nakamura, Masanobu Ohishi, Tomoya Matsunobu, Yasuharu Nakashima, Akio Sakamoto, Akira Maekawa, Yoshinao Oda, Yukihide Iwamoto

    Modern Rheumatology   28 ( 5 )   906 - 910   2018.9

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    DOI: 10.3109/14397595.2016.1173322

  • Radiological features of IDO1+/PDL1+ lung adenocarcinoma A retrospective single-institution study Reviewed

    Kazuki Takada, Gouji Toyokawa, Tetsuzo Tagawa, Mototsugu Shimokawa, Kenichi Kouhashi, Akira Haro, Atsushi Osoegawa, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   38 ( 9 )   5295 - 5303   2018.9

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    DOI: 10.21873/anticanres.12856

  • Low grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion A case report Reviewed

    Yurie Mikami, Shinsuke Fujii, Kenichi Kouhashi, Yuichi Yamada, Masafumi Moriyama, Shintarou Kawano, Seiji Nakamura, Yoshinao Oda, Tamotsu Kiyoshima

    Oncology Letters   16 ( 3 )   3889 - 3894   2018.9

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    DOI: 10.3892/ol.2018.9115

  • Indoleamine 2,3-dioxygenase 1 and programmed cell death-ligand 1 co-expression correlates with aggressive features in lung adenocarcinoma Reviewed

    Yuka Kozuma, Kazuki Takada, Gouji Toyokawa, Kenichi Kouhashi, Mototsugu Shimokawa, Fumihiko Hirai, Tetsuzo Tagawa, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    European Journal of Cancer   101   20 - 29   2018.9

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    DOI: 10.1016/j.ejca.2018.06.020

  • Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer Reviewed

    Yuka Inoue, Nami Yamashita, Hiroyuki Kitao, Kimihiro Tanaka, Hiroshi Saeki, Eiji Oki, Yoshinao Oda, Eriko Tokunaga, Yoshihiko Maehara

    Clinical Breast Cancer   18 ( 4 )   e643 - e650   2018.8

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    DOI: 10.1016/j.clbc.2017.11.008

  • Overexpression of mth1 and ogg1 proteins in ulcerative colitis-associated carcinogenesis Reviewed

    Yoshiteru Kumagae, Minako Hirahashi, Katsumi Takizawa, Hidetaka Yamamoto, Masaki Gushima, Motohiro Esaki, Takayuki Matsumoto, Masafumi Nakamura, Takanari Kitazono, Yoshinao Oda

    Oncology Letters   16 ( 2 )   1765 - 1776   2018.8

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    DOI: 10.3892/ol.2018.8812

  • Neuroendocrine tumor of the pancreas with rhabdoid feature Reviewed

    Tetsuyuki Miyazaki, Shinichi Aishima, Minoru Fujino, Keigo Ozono, yuichiro kubo, yasuhiro ushijima, Takashi Osoegawa, Eikichi Ihara, Itou Tetsuhide, Ohtsuka Takao, Masafumi Nakamura, Yoshinao Oda

    Virchows Archiv   473 ( 2 )   247 - 252   2018.8

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    DOI: 10.1007/s00428-018-2398-x

  • Cancer management in kabuki syndrome The first case of wilms tumor and a literature review Reviewed

    Hideto Teranishi, Yuhki Koga, Kentaro Nakashima, Eiji Morihana, Kanako Ishii, Yasunari Sakai, Tomoaki Taguchi, Yoshinao Oda, Noriko Miyake, Naomichi Matsumoto, Shoichi Ohga

    Journal of Pediatric Hematology/Oncology   40 ( 5 )   391 - 394   2018.7

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    DOI: 10.1097/MPH.0000000000001111

  • Visualizing energy charge in breast carcinoma tissues by MALDI mass-spectrometry imaging profiles of low-molecular-weight metabolites Reviewed

    Nobuhiro Torata, Makoto Kubo, Daisuke Miura, Kenoki Ouchida, yusuke mizuuchi, Yoshinori Fujimura, Eisuke Hayakawa, Masaya Kai, Yoshinao Oda, Kazuhiro Mizumoto, Makoto Hashizume, Masafumi Nakamura

    Anticancer research   38 ( 7 )   4267 - 4272   2018.7

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    DOI: 10.21873/anticanres.12723

  • The significant influence of having children on the postoperative prognosis of patients with nonsmall cell lung cancer A propensity score-matched analysis Reviewed

    Shinkichi Takamori, Tetsuzo Tagawa, Gouji Toyokawa, Hiroki Ueo, Mototsugu Shimokawa, Fumihiko Kinoshita, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Takaki Akamine, Masakazu Katsura, Kazuki Takada, Fumihiko Hirai, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   7 ( 7 )   2860 - 2867   2018.7

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    DOI: 10.1002/cam4.1539

  • Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade Reviewed

    Kentaro Tanaka, Toyoshi Yanagihara, Yuki Ikematsu, Hiroyuki Inoue, keiichi ota, Eiji Kashiwagi, Kunihiro Suzuki, Naoki Hamada, ario takeuchi, Katsunori Tatsugami, Masatoshi Eto, Kayo Ijichi, Yoshinao Oda, Kohei Otsubo, Yasuto Yoneshima, Eiji Iwama, Yoichi Nakanishi, Isamu Okamoto

    Oncotarget   9 ( 55 )   30587 - 30593   2018.7

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    DOI: 10.18632/oncotarget.25743

  • A case of pseudoglandular hepatocellular carcinoma The usefulness of a multimodal approach Reviewed

    Hirofumi Watanabe, Yoshiki Asayama, Akihiro Nishie, Kosei Ishigami, yasuhiro ushijima, Daisuke Okamoto, nobuhiro fujita, Tomoharu Yoshizumi, Yoshinao Oda, Hiroshi Honda

    Radiology Case Reports   13 ( 3 )   689 - 692   2018.6

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    DOI: 10.1016/j.radcr.2018.03.022

  • Class III β-Tubulin Overexpression Induces Chemoresistance to Eribulin in a Leiomyosarcoma Cell Line. Reviewed International journal

    2018.6

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    DOI: 10.1155/2018/8987568

  • Significance of Spread Through Air Spaces in Resected Pathological Stage I Lung Adenocarcinoma Reviewed

    Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Yoshinao Oda, Yoshihiko Maehara

    Annals of Thoracic Surgery   105 ( 6 )   1655 - 1663   2018.6

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    DOI: 10.1016/j.athoracsur.2018.01.037

  • Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation Reviewed

    Shinkichi Takamori, Gouji Toyokawa, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Nobutaka Mukae, Fumihiko Hirai, Tetsuzo Tagawa, Yoshinao Oda, Toru Iwaki, Koji Iihara, Hiroshi Honda, Yoshihiko Maehara

    Anticancer research   38 ( 6 )   3731 - 3734   2018.6

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    DOI: 10.21873/anticanres.12653

  • Prevalence of enhancer of zeste homolog 2 in patients with resected small cell lung cancer Reviewed

    Gouji Toyokawa, Kazuki Takada, Tetsuzo Tagawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Fumihiko Hirai, Yuichi Yamada, Ryuji Hamamoto, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   38 ( 6 )   3707 - 3711   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.12649

  • CD163 is required for protumoral activation of macrophages in human and murine sarcoma Reviewed

    Daisuke Shiraishi, Yukio Fujiwara, Hasita Horlad, Yoichi Saito, Toyohisa Iriki, Junko Tsuboki, Pan Cheng, Naomi Nakagata, Hiroshi Mizuta, Hirofumi Bekki, Yasuharu Nakashima, Yoshinao Oda, Motohiro Takeya, Yoshihiro Komohara

    Cancer Research   78 ( 12 )   3255 - 3266   2018.6

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    DOI: 10.1158/0008-5472.CAN-17-2011

  • Clinical Impact and Risk Factors for Skeletal Muscle Loss After Complete Resection of Early Non-small Cell Lung Cancer Reviewed

    Shinkichi Takamori, Gouji Toyokawa, Tatsuro Okamoto, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Kazuki Takada, Masakazu Katsura, Fumihiko Hirai, Fumihiro Shoji, Tetsuzo Tagawa, Yoshinao Oda, Hiroshi Honda, Yoshihiko Maehara

    Annals of Surgical Oncology   25 ( 5 )   1229 - 1236   2018.5

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    DOI: 10.1245/s10434-017-6328-y

  • Deregulated mucosal immune surveillance through gut-Associated regulatory t cells and PD-1 + t cells in human colorectal cancer Reviewed

    Hanae Fujimoto, Yoriko Saito, Kenoki Ouchida, Eiryo Kawakami, Saera Fujiki, Takashi Watanabe, Rintaro Ono, Akiko Kaneko, Shinsuke Takagi, Yuho Najima, Atsushi Hijikata, Lin Cui, Takashi Ueki, Yoshinao Oda, Shohei Hori, Osamu Ohara, Masafumi Nakamura, Takashi Saito, Fumihiko Ishikawa

    Journal of Immunology   200 ( 9 )   3291 - 3303   2018.5

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    DOI: 10.4049/jimmunol.1701222

  • Successful treatment of growing teratoma syndrome of the lung by surgical resection A case report and literature review Reviewed

    Kensuke Tanaka, Gouji Toyokawa, Tetsuzo Tagawa, Kayo Ijichi, Naoki Haratake, Fumihiko Hirai, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   38 ( 5 )   3115 - 3118   2018.5

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    DOI: 10.21873/anticanres.12571

  • Effect of cartilaginous endplates on extruded disc resorption in lumbar disc herniation Reviewed

    Kenichi Kawaguchi, Katsumi Harimaya, Yoshihiro Matsumoto, Mitsumasa Hayashida, Seiji Okada, Keiichiro Iida, Go Kato, Kuniyoshi Tsuchiya, Toshio Doi, Yoshinao Oda, Yukihide Iwamoto, Yasuharu Nakashima

    PloS one   13 ( 4 )   2018.4

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    DOI: 10.1371/journal.pone.0195946

  • Wnt/β-catenin signal alteration and its diagnostic utility in basal cell adenoma and histologically similar tumors of the salivary gland Reviewed

    214 ( 4 )   586 - 592   2018.4

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    Differential diagnosis among basal cell adenoma (BCA), basal cell adenocarcinoma (BCAC), adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) of the salivary gland can be challenging due to their similar histological appearance. Although frequent nuclear β-catenin expression and CTNNB1 mutations have been reported in BCA, further details of the Wnt/β-catenin signal alterations are unclear. The aim of this study was to assess the diagnostic utility of Wnt/β-catenin signal alteration in BCA and morphological mimics. We performed immunohistochemical staining for β-catenin and mutation analysis for Wnt/β-catenin-related genes (CTNNB1, APC, AXIN1 and AXIN2) in BCA (n = 34), BCAC (n = 3), ACC (n = 67) and PA (n = 31). We also analyzed ACC-specific MYB and MYBL1 gene rearrangements by fluorescence in situ hybridization (FISH). Nuclear β-catenin expression (≥3%) was present in 32/34 cases (94.1%) of BCA, and the nuclear β-catenin labeling index was significantly higher than in other tumor types (p = < 0.0001). In BCA, we found mutations in CTNNB1, APC and AXIN1 genes (41.1%, 2.9% and 8.8%, respectively). In BCAC, nuclear β-catenin expression with CTNNB1 mutation was present in 1/3 cases (33.3%). As for ACC, nuclear β-catenin expression was observed in 3/67 cases (4.4%), but all 3 cases harbored either MYB or MYBL1 gene rearrangement. The results suggest that nuclear β-catenin immunoreactivity with appropriate criteria may be helpful to distinguish BCA from histologically similar tumors. However, a minor subset of ACCs with nuclear β-catenin expression require careful diagnosis. In addition, Wnt/β-catenin signal alteration may play a role in the pathogenesis of BCA and BCAC.

    DOI: 10.1016/j.prp.2017.12.016

  • The novel selective pan-TRK inhibitor ONO-7579 exhibits antitumor efficacy against human gallbladder cancer in vitro Reviewed

    Makoto Kawamoto, Keigo Ozono, Yasuhiro Oyama, Akio Yamasaki, Yoshinao Oda, Hideya Ohnishi

    Anticancer research   38 ( 4 )   1979 - 1986   2018.4

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    DOI: 10.21873/anticanres.12435

  • Successful chemotherapeutic treatment for metastatic littoral cell angioma A case report Reviewed

    Kotoe Takayoshi, Goro Doi, Nobuhiro Tsuruta, Tomoyasu Yoshihiro, Kenta Nio, Kenji Tsuchihashi, hiroshi ariyama, Jun Odawara, Shinji Shimoda, Kenichi Kouhashi, Yoshinao Oda, shinji itoh, Norifumi Harimoto, Yoshihiko Maehara, Hitoshi Kusaba, Koichi Akashi, Eishi Baba

    Medicine (United States)   97 ( 15 )   2018.4

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    DOI: 10.1097/MD.0000000000010378

  • PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements Reviewed

    Yasuto Yoneshima, Kayo Ijichi, Satoshi Anai, keiichi ota, Kohei Otsubo, Eiji Iwama, Kentaro Tanaka, Yoshinao Oda, Yoichi Nakanishi, Isamu Okamoto

    Lung Cancer   118   36 - 40   2018.4

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    DOI: 10.1016/j.lungcan.2018.01.024

  • Osteogenic differentiation in dedifferentiated liposarcoma a study of 36 cases in comparison to the cases without ossification Reviewed

    Kyoko Yamashita, Kenichi Kouhashi, Yuichi Yamada, Takeaki Ishii, Yoshihiro Nishida, Hiroshi Urakawa, Ichiro Ito, Mitsuru Takahashi, Takeshi Inoue, Masafumi Ito, Yuuki Ohara, Yoshinao Oda, Shinya Toyokuni

    Histopathology   72 ( 5 )   729 - 738   2018.4

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    DOI: 10.1111/his.13421

  • Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma Reviewed

    nobuko yasutake, Yoshihiro Ohishi, Kenichi Taguchi, Yuka Hiraki, Masafumi Oya, Yumi Oshiro, Mari Mine, Takeshi Iwasaki, Hidetaka Yamamoto, Kenichi Kouhashi, Kenzo Sonoda, Kiyoko Kato, Yoshinao Oda

    Histopathology   72 ( 5 )   739 - 748   2018.4

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    DOI: 10.1111/his.13422

  • Gastric cancer of "Crawling type" detected by additional gastrectomy after endoscopic submucosal resection Reviewed

    Yasuhiro Haruta, Ryota Nakanishi, Tomoko Jogo, Yuichiro Nakashima, Hiroshi Saeki, Eiji Oki, Minako Fujiwara, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   38 ( 4 )   2335 - 2338   2018.4

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    DOI: 10.21873/anticanres.12479

  • A novel histological examination with dynamic three-dimensional reconstruction from multiple immunohistochemically stained sections of a PD-L1-positive colon cancer Reviewed International journal

    Shotaro Korehisa, Tetsuo Ikeda, Shinji Okano, Hiroshi Saeki, Eiji Oki, Yoshinao Oda, Makoto Hashizume, Yoshihiko Maehara

    Histopathology   72 ( 4 )   697 - 703   2018.3

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    DOI: 10.1111/his.13400

  • Liver-enriched transcription factor expression relates to chronic hepatic failure in humans Reviewed International journal

    Hepatology Communications   2018.3

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    DOI: 0.1002/hep4.1172.

  • Immunohistochemical evaluation of H3K27 trimethylation in malignant peripheral nerve sheath tumors Reviewed International journal

    Hiroshi Otsuka, Kenichi Kouhashi, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yuichi Yamada, Hidetaka Yamamoto, Yasuharu Nakashima, Yoshinao Oda

    Pathology Research and Practice   214 ( 3 )   417 - 425   2018.3

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    DOI: 10.1016/j.prp.2017.12.015

  • High frequency of spread through air spaces in resected small cell lung cancer Reviewed International journal

    Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Fumihiko Hirai, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   38 ( 3 )   1821 - 1825   2018.3

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    DOI: 10.21873/anticanres.12421

  • Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger Reviewed International journal

    Xiaopeng Bai, Eikichi Ihara, Katsuya Hirano, Yoshimasa Tanaka, Kayoko Nakano, Satomi Kita, Takahiro Iwamoto, Haruei Ogino, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, Yoshihiro Ogawa

    CMGH Cellular and Molecular Gastroenterology and Hepatology   5 ( 3 )   209 - 221   2018.3

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    DOI: 10.1016/j.jcmgh.2017.11.004

  • Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone Reviewed International journal

    Hidetaka Yamamoto, Takeshi Iwasaki, Yuichi Yamada, Yoshihiro Matsumoto, Hiroshi Otsuka, Masato Yoshimoto, Kenichi Kouhashi, Kenichi Taguchi, Ryohei Yokoyama, Yasuharu Nakashima, Yoshinao Oda

    Human Pathology   73   41 - 50   2018.3

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    DOI: 10.1016/j.humpath.2017.11.020

  • Association of preoperative serum CRP with PD-L1 expression in 508 patients with non-small cell lung cancer A comprehensive analysis of systemic inflammatory markers Reviewed International journal

    Takaki Akamine, Kazuki Takada, Gouji Toyokawa, Fumihiko Kinoshita, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Fumihiko Hirai, Tetsuzo Tagawa, Tatsuro Okamoto, Yasuto Yoneshima, Isamu Okamoto, Mototsugu Shimokawa, Yoshinao Oda, Yoichi Nakanishi, Yoshihiko Maehara

    Surgical Oncology   27 ( 1 )   88 - 94   2018.3

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    DOI: 10.1016/j.suronc.2018.01.002

  • Clinical significance of programmed cell death-ligand 1 expression and the immune microenvironment at the invasive front of colorectal cancers with high microsatellite instability Reviewed International journal

    Shotaro Korehisa, Eiji Oki, Makoto Iimori, Yu Nakaji, Mototsugu Shimokawa, Hiroshi Saeki, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara

    International Journal of Cancer   142 ( 4 )   822 - 832   2018.2

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    DOI: 10.1002/ijc.31107

  • Surveillance of patients with intraductal papillary mucinous neoplasm with and without pancreatectomy with special reference to the incidence of concomitant pancreatic ductal adenocarcinoma Reviewed

    Kenjiro Date, Takao Ohtsuka, So Nakamura, Naoki Mochidome, Yasuhisa Mori, Yoshihiro Miyasaka, Yoshinao Oda, Masafumi Nakamura

    Surgery (United States)   163 ( 2 )   291 - 299   2018.2

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    DOI: 10.1016/j.surg.2017.09.040

  • Value of Intraoperative Cytological and Pathological Sentinel Lymph Node Diagnosis in Fertility-Sparing Trachelectomy for Early-Stage Cervical Cancer Reviewed International journal

    Kenzo Sonoda, Hideaki Yahata, Okugawa Kaoru, Kaneki Eisuke, Tatsuhiro Ogami, Masafumi Yasunaga, Shingo Baba, Yoshinao Oda, Hiroshi Honda, Kiyoko Kato

    Oncology   94 ( 2 )   92 - 98   2018.2

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    DOI: 10.1159/000484049

  • The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research Standard operating procedures based on empirical analyses Reviewed International journal

    Yae Kanai, Hiroshi Nishihara, Yohei Miyagi, Tatsuhiro Tsuruyama, Kenichi Taguchi, Hiroto Katoh, Tomoyo Takeuchi, Masahiro Gotoh, Junko Kuramoto, Eri Arai, Hidenori Ojima, Ayako Shibuya, Teruhiko Yoshida, Toshiaki Akahane, Rika Kasajima, Kei Ichi Morita, Johji Inazawa, Takeshi Sasaki, Masashi Fukayama, Yoshinao Oda

    Pathology International   68 ( 2 )   63 - 90   2018.2

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    DOI: 10.1111/pin.12631

  • Programmed Death-Ligand 1 Expression and EGFR Mutations in Multifocal Lung Cancer Reviewed International journal

    Naoki Haratake, Gouji Toyokawa, Kazuki Takada, Yuka Kozuma, Taichi Matsubara, Shinkichi Takamori, Takaki Akamine, Masakazu Katsura, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Annals of Thoracic Surgery   105 ( 2 )   448 - 454   2018.2

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    DOI: 10.1016/j.athoracsur.2017.09.025

  • Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion Reviewed International journal

    Shinji Kohsaka, Tsuyoshi Saito, Keisuke Akaike, Yoshiyuki Suehara, Takuo Hayashi, Tatsuya Takagi, Kazuo Kaneko, Toshihide Ueno, Shinya Kojima, Kenichi Kouhashi, Hiroyuki Mano, Yoshinao Oda, Takashi Yao

    Human Pathology   72   167 - 173   2018.2

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    DOI: 10.1016/j.humpath.2017.08.017

  • PD-L1 expression according to the EGFR status in primary lung adenocarcinoma Reviewed International journal

    Kazuki Takada, Gouji Toyokawa, Tetsuzo Tagawa, Kenichi Kouhashi, Mototsugu Shimokawa, Takaki Akamine, Shinkichi Takamori, Fumihiko Hirai, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Lung Cancer   116   1 - 6   2018.2

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    DOI: 10.1016/j.lungcan.2017.12.003

  • Mucinous adenocarcinoma of the thymus report of a case Reviewed International journal

    Fumihiko Kinoshita, Fumihiro Shoji, Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Tokujiro Yano, Yoshinao Oda, Yoshihiko Maehara

    General Thoracic and Cardiovascular Surgery   66 ( 2 )   111 - 115   2018.2

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    DOI: 10.1007/s11748-017-0781-1

  • Histopathological and genetic review of phosphaturic mesenchymal tumours, mixed connective tissue variant Reviewed International journal

    Yuichi Yamada, Izumi Kinoshita, Kohashi Kenichi, Hidetaka Yamamoto, Takeshi Iwasaki, Hiroshi Otsuka, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yuki Kuma, Nokitaka Setsu, Yuki Koga, Yumi Honda, Takeshi Inoue, Hiroyuki Yanai, Kyoko Yamashita, Ichiro Ito, Mitsuru Takahashi, Shouichi Ohga, Masutaka Furue, Yasuharu Nakashima, Yoshinao Oda

    Histopathology   72 ( 3 )   460 - 471   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/his.13377

  • A combination of MTAP and BAP1 immunohistochemistry in pleural effusion cytology for the diagnosis of mesothelioma Reviewed International journal

    Yoshiaki Kinoshita, Tomoyuki Hida, Makoto Hamasaki, Shinji Matsumoto, Ayuko Sato, Tohru Tsujimura, Kunimitsu Kawahara, Kenzo Hiroshima, Yoshinao Oda, Kazuki Nabeshima

    Cancer cytopathology   126 ( 1 )   54 - 63   2018.1

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    DOI: 10.1002/cncy.21928

  • Metyrapone-responsive ectopic acth-secreting pheochromocytoma with a vicious cycle via a glucocorticoid-driven positive-feedback mechanism Reviewed

    Minako Inoue, Ken Okamura, Chie Kitaoka, Fumio Kinoshita, Ryo Namitome, Udai Nakamura, Masaki Shiota, Kenichi Goto, Toshio Ohtsubo, Kiyoshi Matsumura, Yoshinao Oda, Masatoshi Eto, Takanari Kitazono

    Endocrine Journal   65 ( 7 )   755 - 767   2018.1

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    DOI: 10.1507/endocrj.EJ18-0025

  • A case of solitary fibrous tumor Reviewed

    Tomoyo Matsuda, Yuko Haraguchi, Satoko Shibata-Kikuchi, Fumiyoshi Fushimi, Yuichi Yamada, Yoshinao Oda, Masutaka Furue

    Nishinihon Journal of Dermatology   80 ( 5 )   450 - 454   2018.1

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    DOI: 10.2336/nishinihonhifu.80.450

  • ‘Microcystic pattern’ should be recognised as part of the morphological spectrum of solid-pseudopapillary neoplasm of the pancreas Reviewed International journal

    72 ( 2 )   216 - 226   2018.1

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    Aim: Solid pseudopapillary neoplasm (SPN) is an uncommon pancreatic tumour characterised by solid and pseudopapillary growth patterns. We have observed SPNs can show a microcystic pattern (microcystic SPN), which has been poorly described and may be confused with microcystic neoplasms. We conducted the present study to clarify the clinicopathological and immunohistochemical features of microcystic SPNs. Methods and results: We examined a consecutive series of 44 SPNs and 10 serous cystadenomas (SCAs), and classified them into 13 microcystic SPNs (29.5%) and 31 conventional SPNs (70.5%). Clinicopathological analysis, immunohistochemical staining and mucin histochemistry were performed. Clear cell change, hyalinised stroma and haemorrhage were observed significantly more frequently in the microcystic SPNs compared to the conventional SPNs. Immunohistochemically, the microcystic SPNs showed significantly lower frequencies of CD10 (0%) and CD56 expression (62%) compared to the conventional SPNs (87%; P < 0.001, 90%; P < 0.0085, respectively). There were no significant differences in other clinicopathological and immunohistochemical features between the two groups (i.e. the nuclear expression of β-catenin, E-cadherin, progesterone receptor (PgR), lack of forkhead box (Fox)L2 and occasional oestrogen receptor (ER), AE1/AE3 expression). Microcystic SCAs lack such a characteristic immunophenotype. The myxoid stroma of microcystic SPNs contained hyaluronan revealed by Alcian blue stain with hyaluronidase digestion. Conclusion: We thus conclude that the microcystic pattern should be recognised as a part of the morphological spectrum of SPNs. Our findings may contribute to the correct diagnosis of the pancreatic neoplasms with the microcystic pattern. In addition, we speculate that stromal change caused by an accumulation of hyaluronan may contribute to the microcystic pattern of SPN.

    DOI: 10.1111/his.13376

  • Significance of Spread Through Air Spaces in Resected Lung Adenocarcinomas With Lymph Node Metastasis Reviewed International journal

    Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Fumihiko Hirai, Yoshinao Oda, Yoshihiko Maehara

    Clinical Lung Cancer   2018.1

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    DOI: 10.1016/j.cllc.2018.04.002

  • SWI/SNF Chromatin-remodeling Complex Status in SMARCB1/INI1-preserved Epithelioid Sarcoma Reviewed

    Kenichi Kouhashi, Hidetaka Yamamoto, Yuichi Yamada, Izumi Kinoshita, Tomoaki Taguchi, Yukihide Iwamoto, Yoshinao Oda

    American Journal of Surgical Pathology   42 ( 3 )   312 - 318   2018.1

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    DOI: 10.1097/PAS.0000000000001011

  • Role of SpyGlass-DStm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct Reviewed International journal

    Ohtsuka Takao, Yoshitaka Gotoh, Yohei Nakashima, Yoshifumi Okayama, So Nakamura, Makiko Morita, Mohammed Yahia Farrag Aly, Vittoria Vanessa D.M. Velasquez, Yasuhisa Mori, Yoshihiko Sadakari, Kohei Nakata, Yoshihiro Miyasaka, Kosei Ishigami, Nao Fujimori, Naoki Mochidome, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura

    Pancreatology   2018.1

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    DOI: 10.1016/j.pan.2018.04.012

  • Laparoscopic surgery for congenital biliary dilatation a single-institution experience Reviewed International journal

    Mohammed Yahia Farrag Aly, Yasuhisa Mori, Yoshihiro Miyasaka, Ohtsuka Takao, Yoshihiko Sadakari, Kohei Nakata, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura

    Surgery Today   48 ( 1 )   44 - 50   2018.1

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    DOI: 10.1007/s00595-017-1545-3

  • Interstitial pneumonia caused by dabigatran Reviewed International journal

    Toyoshi Yanagihara, Norio Yamamoto, Yasuaki Kotetsu, Naoki Hamada, Eiji Harada, Kunihiro Suzuki, Kayo Ijichi, Yoshinao Oda, Yoichi Nakanishi

    Respiratory Medicine Case Reports   23   10 - 12   2018.1

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    DOI: 10.1016/j.rmcr.2017.10.009

  • Hepatobiliary and Pancreatic Pregnancy induced hepatic veno-occlusive disease requiring liver transplantation Reviewed International journal

    Norifumi Harimoto, K. Yugawa, Toru Ikegami, M. Ohira, Yohei Mano, T. Motomura, Takeo Toshima, shinji itoh, N. Harada, Yuji Soejima, Tomoharu Yoshizumi, Yoshihiko Maehara, Yoshinao Oda

    Journal of Gastroenterology and Hepatology (Australia)   33 ( 1 )   2018.1

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    DOI: 10.1111/jgh.13975

  • Fever and skin involvement at diagnosis predicting the intractable langerhans cell histiocytosis 40 case-series in a single center Reviewed International journal

    Tetsuko Kobayashi, Yuhki Koga, masataka ishimura, Kentaro Nakashima, Wakako Kato, Hiroaki Ono, Motoshi Sonoda, Katsuhide Eguchi, Reiji Fukano, Satoshi Honjo, Yoshinao Oda, Shoichi Ohga

    Journal of Pediatric Hematology/Oncology   40 ( 3 )   e148 - e153   2018.1

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    DOI: 10.1097/MPH.0000000000001080

  • Feasibility of prophylactic pancreatojejunostomy in possible high-risk patients for prevention of pancreatic fistula during enucleation or limited pancreatic resection Reviewed International journal

    Ohtsuka Takao, Yasuhisa Mori, Takaaki Fujimoto, Yoshihiro Miyasaka, Kohei Nakata, Kenoki Ouchida, Eishi Nagai, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura

    American Surgeon   84 ( 1 )   149 - 153   2018.1

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  • Fatal cardiac hemochromatosis in a patient with hereditary spherocytosis Reviewed International journal

    Takeo Fujino, Shujiro Inoue, Shunsuke Katsuki, Taiki Higo, Tomomi Ide, Yoshinao Oda, Hiroyuki Tsutsui

    International Heart Journal   59 ( 2 )   427 - 430   2018.1

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    DOI: 10.1536/ihj.17-160

  • Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients Reviewed International journal

    Masakazu Katsura, Fumihiro Shoji, Tatsuro Okamoto, Shinichiro Shimamatsu, Fumihiko Hirai, Gouji Toyokawa, Yosuke Morodomi, Tetsuzo Tagawa, Yoshinao Oda, Yoshihiko Maehara

    Cancer Science   109 ( 1 )   154 - 165   2018.1

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    DOI: 10.1111/cas.13422

  • Clinicopathologic and molecular characteristics of synchronous colorectal carcinoma with mismatch repair deficiency Reviewed International journal

    Kayoko Nakano, Hidetaka Yamamoto, Minako Fujiwara, Yutaka Koga, Shinichi Tsuruta, Eikichi Ihara, Eiji Oki, Masafumi Nakamura, Yoshihiro Ogawa, Yoshinao Oda

    American Journal of Surgical Pathology   42 ( 2 )   172 - 182   2018.1

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    DOI: 10.1097/PAS.0000000000000947

  • Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer Reviewed International journal

    Shinkichi Takamori, Gouji Toyokawa, Isamu Okamoto, Kazuki Takada, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Nobutaka Mukae, Fumihiko Hirai, Tetsuzo Tagawa, Yoshinao Oda, Toru Iwaki, Koji Iihara, Yoichi Nakanishi, Yoshihiko Maehara

    Anticancer Research   38 ( 1 )   553 - 557   2018.1

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    DOI: 10.21873/anticanres.12258

  • Cancer-testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non-uterine leiomyosarcoma Reviewed International journal

    Kunio Iura, Kenichi Kouhashi, Nobuko Yasutake, Takeaki Ishii, Akira Maekawa, Hirofumi Bekki, Hiroshi Otsuka, Yuichi Yamada, Hidetaka Yamamoto, Yoshihiro Ohishi, Yoshihiro Matsumoto, Yukihide Iwamoto, Yoshinao Oda

    Oncology Letters   15 ( 1 )   441 - 446   2018.1

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    DOI: 10.3892/ol.2017.7274

  • An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation Reviewed International journal

    Hironori Mikumo, Toyoshi Yanagihara, Naoki Hamada, Mikiko Hashisako, Kayo Ijichi, Kunihiro Suzuki, Eiji Harada, Yasunori Shikada, Yoshinao Oda, Yoichi Nakanishi

    Respiratory Medicine Case Reports   24   92 - 94   2018.1

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    DOI: 10.1016/j.rmcr.2018.04.016

  • A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors Reviewed International journal

    Yasuki Hijikata, Toshihiko Okazaki, Yoshihiro Tanaka, Mutsunori Murahashi, Yuichi Yamada, Kazunari Yamada, Atsushi Takahashi, Hiroyuki Inoue, Junji Kishimoto, Yoichi Nakanishi, Yoshinao Oda, Yusuke Nakamura, Kenzaburo Tani

    PLoS One   13 ( 1 )   2018.1

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    DOI: 10.1371/journal.pone.0187878

  • A novel fusion gene CRTC3-MAML2 in hidradenoma histopathological significance Reviewed International journal

    Yuki Kuma, Yuichi Yamada, Hidetaka Yamamoto, Kenichi Kouhashi, Takamichi Ito, Masutaka Furue, Yoshinao Oda

    Human Pathology   70   55 - 61   2017.12

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    DOI: 10.1016/j.humpath.2017.10.004

  • SMARCA4-deficient thoracic sarcoma report of a case and insights into how to reach the diagnosis using limited samples and resources Reviewed International journal

    Satoshi Kuwamoto, Michiko Matsushita, Kenichi Takeda, Natsumi Tanaka, Yukari Endo, Akira Yamasaki, Kenichi Kouhashi, Yoshinao Oda, Yasushi Horie

    Human Pathology   70   92 - 97   2017.12

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    DOI: 10.1016/j.humpath.2017.05.024

  • Protein Expression of Programmed Death 1 Ligand 1 and HER2 in Gastric Carcinoma Reviewed International journal

    Eiji Oki, Shinji Okano, Hiroshi Saeki, Yuichiro Umemoto, Koji Teraishi, Yu Nakaji, Kouji Andou, Yoko Zaitsu, Nami Yamashita, Masahiko Sugiyama, Yuichiro Nakashima, Kippei Ohgaki, Yoshinao Oda, Yoshihiko Maehara

    Oncology   93 ( 6 )   387 - 394   2017.12

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    DOI: 10.1159/000479231

  • In vivo and ex vivo methods of growing a liver bud through tissue connection Reviewed International journal

    Yusuke Yanagi, Koichi Nakayama, Tomoaki Taguchi, Shin Enosawa, Tadashi Tamura, Koichiro Yoshimaru, Toshiharu Matsuura, Makoto Hayashida, Kenichi Kouhashi, Yoshinao Oda, Takayoshi Yamaza, Eiji Kobayashi

    Scientific Reports   7 ( 1 )   2017.12

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    DOI: 10.1038/s41598-017-14542-2

  • Histopathologic diversity of gastric cancers Relationship between enhancement pattern on dynamic contrast-enhanced CT and histological type Reviewed International journal

    Daisuke Tsurumaru, mitsutoshi miyasaka, Toshio Muraki, Akihiro Nishie, Yoshiki Asayama, Eiji Oki, Yoshinao Oda, Hiroshi Honda

    European Journal of Radiology   97   90 - 95   2017.12

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    DOI: 10.1016/j.ejrad.2017.10.018

  • Diagnostic application of BAP1 immunohistochemistry to differentiate pleural mesothelioma from metastatic pleural tumours Reviewed International journal

    Masayo Yoshimura, Yoshiaki Kinoshita, Makoto Hamasaki, Shinji Matsumoto, Tomoyuki Hida, Yoshinao Oda, Kazuki Nabeshima

    Histopathology   71 ( 6 )   1011 - 1014   2017.12

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    DOI: 10.1111/his.13321

  • Association Between PD-L1 Expression and Metabolic Activity on 18F-FDG PET/CT in Patients with Small-sized Lung Cancer Reviewed International journal

    Kazuki Takada, Gouji Toyokawa, Tetsuzo Tagawa, Kenichi Kouhashi, Takaki Akamine, Shinkichi Takamori, Fumihiko Hirai, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   37 ( 12 )   7073 - 7082   2017.12

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  • Brain-derived neurotrophic factor/tropomyosin-related kinase B signaling pathway contributes to the aggressive behavior of lung squamous cell carcinoma Reviewed International journal

    Keigo Ozono, Yoshihiro Ohishi, Hideya Ohnishi, Katsuya Nakamura, Junichi Motoshita, Masato Kato, Ryoichi Nakanishi, Masafumi Nakamura, Yoshinao Oda

    Laboratory Investigation   97 ( 11 )   1332 - 1342   2017.11

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    DOI: 10.1038/labinvest.2017.45

  • S100P in Duodenal Fluid Is a Useful Diagnostic Marker for Pancreatic Ductal Adenocarcinoma Reviewed International journal

    Taketo Matsunaga, Ohtsuka Takao, Koichi Asano, Hideyo Kimura, Kenoki Ouchida, Hidehisa Kitada, Noboru Ideno, Yasuhisa Mori, Shoji Tokunaga, Yoshinao Oda, Sushovan Guha, Massimo Raimondo, Masafumi Nakamura, Masao Tanaka

    Pancreas   46 ( 10 )   1288 - 1295   2017.11

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    DOI: 10.1097/MPA.0000000000000940

  • Metabolic characteristics of programmed cell death-ligand 1-expressing lung cancer on 18F-fluorodeoxyglucose positron emission tomography/computed tomography Reviewed International journal

    Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Shingo Baba, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Fumihiro Shoji, Hiroshi Honda, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   6 ( 11 )   2552 - 2561   2017.11

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    DOI: 10.1002/cam4.1215

  • Lingual alveolar soft part sarcoma responsive to pazopanib A case report Reviewed International journal

    Tomoyasu Yoshihiro, Kenji Tsuchihashi, Kenta Nio, Shuji Arita, Takafumi Nakano, Ryuji Yasumatsu, Rina Jiroumaru, hiroshi ariyama, Hitoshi Kusaba, Yoshinao Oda, Koichi Akashi, Eishi Baba

    Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries   96 ( 44 )   e8470   2017.11

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    DOI: 10.1097/MD.0000000000008470

  • Breast angiosarcoma without radiation history, putatively associated with subclinical lymphedema A case report and review of the Japanese literature Reviewed International journal

    Eriko Maehara, Chikage Mitoma, Gaku Tsuji, Takamichi Ito, Uchi Hiroshi, Yoshinao Oda, Masutaka Furue

    Journal of Dermatology   44 ( 10 )   e266 - e267   2017.10

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    DOI: 10.1111/1346-8138.13917

  • Positive conversion of PD-L1 expression after treatments with chemotherapy and nivolumab Reviewed International journal

    Naoki Haratake, Gouji Toyokawa, Tetsuzo Tagawa, Yuka Kozuma, Taichi Matsubara, Shinkichi Takamori, Takaki Akamine, Yuichi Yamada, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   37 ( 10 )   5713 - 5717   2017.10

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    DOI: 10.21873/anticanres.12009

  • Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1 Reviewed International journal

    Yuki Ikematsu, Yasuto Yoneshima, Kayo Ijichi, Kentaro Tanaka, Taishi Harada, Yoshinao Oda, Yoichi Nakanishi, Isamu Okamoto

    Lung Cancer   112   230 - 231   2017.10

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    DOI: 10.1016/j.lungcan.2017.07.020

  • Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course) A case report Reviewed International journal

    Yukihiko Okumura, Kenichi Kouhashi, Huanlin Wang, Masaki Kato, Yoshihiko Maehara, Yoshihiro Ogawa, Yoshinao Oda

    Pathology Research and Practice   213 ( 10 )   1322 - 1326   2017.10

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    DOI: 10.1016/j.prp.2017.06.001

  • Chemoradiotherapy for solitary skeletal muscle metastasis from oesophageal cancer Case report and brief literature review Reviewed International journal

    Yoshiaki Fujimoto, Yuichiro Nakashima, Shun Sasaki, Tomoko Jogo, Kosuke Hirose, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Kensuke Kudou, Yu Nakaji, Ryota Nakanishi, Kouji Andou, Hiroshi Saeki, Eiji Oki, Minako Fujiwara, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   37 ( 10 )   5687 - 5691   2017.10

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    DOI: 10.21873/anticanres.12005

  • Alteration of PDGFRβ-Akt-mTOR pathway signaling in fibrosarcomatous transformation of dermatofibrosarcoma protuberans Reviewed International journal

    67   60 - 68   2017.9

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    Dermatofibrosarcoma protuberans (DFSP) is a cutaneous mesenchymal tumor of intermediate malignancy and fibroblastic/myofibroblastic differentiation. Fibrosarcomatous (FS) component is a high-grade component of DFSP. The detailed oncogenic difference between DFSP and FS components is not clear. We thus investigated the Akt-mTOR pathway in both components. We used 65 tumor samples obtained from 65 patients. The phosphorylation of Akt-mTOR pathway proteins (Akt, mTOR, 4EBP1, and S6RP) and PDGFRα/β was assessed by immunohistochemical staining, the results of which were confirmed by Western blotting. The immunohistochemical results were as follows: in ordinary DFSP components, p-PDGFRα–positive tumors were 41.9% (18/43 cases), p-PDGFRβ 55.8% (24/43 cases), p-Akt 51.2% (22/43 cases), p-mTOR 39.5% (17/43 cases), p-4EBP1 46.5% (20/43 cases), and p-S6RP 41.8% (18/43 cases); in DFSP components of FS-DFSP, 52.6% (10/19 cases), 47.4% (9/19 cases), 52.6% (10/19 cases), 36.8% (7/19 cases), 52.6% (10/19 cases), and 52.6% (10/19 cases); and in FS components, 45.5% (10/22 cases), 36.4% (8/22 cases), 72.7% (16/22 cases), 54.5% (12/22 cases), 72.7% (16/22 cases), and 68.2% (15/22 cases), respectively. There were significant positive correlations of the phosphorylation of most of the Akt-mTOR pathway proteins (p-Akt, p-mTOR, p-4EBP1, and p-S6RP) with each other (P <.05). Phospho-PDGFRβ was well correlated with the phosphorylation of Akt-mTOR pathway proteins in DFSP components of ordinary and FS-DFSPs, but these correlations were weaker in FS components. This study suggested the association of activation of Akt-mTOR pathway proteins and PDGFR with the progression of DFSP to FS. The Akt-mTOR pathway is thus a potential therapeutic target in imatinib-resistant DFSP/FS.

    DOI: 10.1016/j.humpath.2017.07.001

  • Soft tissue sarcomas From a morphological to a molecular biological approach Reviewed International journal

    Yoshinao Oda, Hidetaka Yamamoto, Kenichi Kouhashi, Yuichi Yamada, Kunio Iura, Takeaki Ishii, Akira Maekawa, Hirofumi Bekki

    Pathology International   67 ( 9 )   435 - 446   2017.9

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    DOI: 10.1111/pin.12565

  • MAGEA4 expression in bone and soft tissue tumors its utility as a target for immunotherapy and diagnostic marker combined with NY-ESO-1 Reviewed International journal

    Kunio Iura, Kenichi Kouhashi, Takeaki Ishii, Akira Maekawa, Hirofumi Bekki, Hiroshi Otsuka, Yuichi Yamada, Hidetaka Yamamoto, Yoshihiro Matsumoto, Yukihide Iwamoto, Yoshinao Oda

    Virchows Archiv   471 ( 3 )   383 - 392   2017.9

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    DOI: 10.1007/s00428-017-2206-z

  • Highlighted version successful resection of a tracheal metastasis of rectal cancer A case report Reviewed International journal

    Takaki Akamine, Gouji Toyokawa, Kenichi Kouhashi, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Journal of Thoracic Disease   9 ( 9 )   E797 - E800   2017.9

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    DOI: 10.21037/jtd.2017.07.94

  • High Frequency of Programmed Death-ligand 1 Expression in Emphysematous Bullae-associated Lung Adenocarcinomas Reviewed

    18 ( 5 )   504 - 511.e1   2017.9

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    Our objective is to clarify the prevalence of programmed death-ligand-1 (PD-L1) expression in emphysematous bullae (EB)-associated lung adenocarcinomas. Seventy patients (19.0%) were positive for PD-L1 expression. Thirty-six (44.4%) and 29 (58.0%) of 81 and 50 patients with EB and cancer adjoining EB, respectively, were positive for PD-L1 expression. EB-associated lung adenocarcinomas express PD-L1 protein more frequently than those without EB. Objective Emphysematous bullae (EB) are known to be associated with a high incidence of lung cancer; however, the reason for this has yet to be elucidated. The objective of the present study was to clarify the prevalence of programmed death-ligand-1 (PD-L1) expression in EB-associated lung adenocarcinomas. Patients and Methods A total of 369 patients with resected lung adenocarcinoma whose preoperative computed tomography findings were available for the examination of EB were analyzed for PD-L1 expression by immunohistochemistry and evaluated to determine the association between PD-L1 expression and EB-related adenocarcinomas. Results Among 369 patients, EB and cancer adjoining EB (Ca-ADJ) were identified in 81 (22.0%) and 50 (13.6%) patients, respectively. EB and Ca-ADJ were significantly associated with male gender, a smoking habit, a decreased forced expiratory volume in 1 second, a relatively higher tumor grade, advanced T status and stage, the presence of pleural and vessel invasion, invasive pathologic subtypes, and wild-type epidermal growth factor receptor. Seventy patients (19.0%) were positive for PD-L1 expression, whereas the remaining 299 patients (81.0%) were negative. Thirty-six (44.4%) and 29 (58.0%) of 81 and 50 patients with EB and Ca-ADJ, respectively, were positive for PD-L1 expression, which was shown to be significant by the Fisher exact test (P &#x003C; .001 and P &#x003C; .001, respectively). Among the 81 lung adenocarcinomas with EB, Ca-ADJ was significantly associated with PD-L1 expression (P = .021). In a multivariate analysis, the presence of Ca-ADJ was found to be an independent predictor of PD-L1 expression. Conclusions EB-associated lung adenocarcinomas express PD-L1 protein more frequently than those without EB.

    DOI: 10.1016/j.cllc.2016.11.011

  • Clinical significance of circumportal pancreas, a rare congenital anomaly, in pancreatectomy Reviewed International journal

    Ohtsuka Takao, Yasuhisa Mori, Kosei Ishigami, Takaaki Fujimoto, Yoshihiro Miyasaka, Kohei Nakata, Kenoki Ouchida, Eishi Nagai, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura

    American Journal of Surgery   214 ( 2 )   267 - 272   2017.8

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    DOI: 10.1016/j.amjsurg.2016.11.018

  • Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions Reviewed International journal

    Mio Tanaka, Kenichi Kouhashi, Kei Kushitani, Misa Yoshida, Sho Kurihara, Masumi Kawashima, Yuka Ueda, Ryota Sozaki, Yoshiaki Kinoshita, Yoshinao Oda, Yukio Takeshima, Eiso Hiyama, Tomoaki Taguchi, Yukichi Tanaka

    Human Pathology   66   177 - 182   2017.8

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    DOI: 10.1016/j.humpath.2017.06.013

  • Discrepancy in programmed cell death-ligand 1 between primary and metastatic non-small cell lung cancer Reviewed International journal

    Shinkichi Takamori, Gouji Toyokawa, Isamu Okamoto, Kazuki Takada, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Masakazu Katsura, Nobutaka Mukae, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Toru Iwaki, Koji Iihara, Yoichi Nakanishi, Yoshihiko Maehara

    Anticancer Research   37 ( 8 )   4223 - 4228   2017.8

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    DOI: 10.21873/anticanres.11813

  • Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer Reviewed International journal

    Takatoshi Fujishita, Tatsuro Okamoto, Takaki Akamine, Shinkichi Takamori, Kazuki Takada, Masakazu Katsura, Gouji Toyokawa, Fumihiro Shoji, Mototsugu Shimokawa, Yoshinao Oda, Yusaku Nakabeppu, Yoshihiko Maehara

    Lung Cancer   109   52 - 57   2017.7

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    DOI: 10.1016/j.lungcan.2017.04.012

  • The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer Reviewed International journal

    Daisuke Imai, Tomoharu Yoshizumi, Shinji Okano, Hideaki Uchiyama, Toru Ikegami, Norifumi Harimoto, shinji itoh, Yuji Soejima, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   6 ( 7 )   1614 - 1626   2017.7

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    DOI: 10.1002/cam4.1087

  • SLC2A1/GLUT1 expression in mural nodules of intraductal papillary mucinous neoplasm of the pancreas Reviewed International journal

    Yasunori Oda, Shinichi Aishima, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Tetsuyuki Miyazaki, Masao Tanaka, Yoshinao Oda

    Human Pathology   65   71 - 78   2017.7

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    DOI: 10.1016/j.humpath.2017.03.008

  • Molecular Characteristics of Pancreatic Ductal Adenocarcinomas with High-Grade Pancreatic Intraepithelial Neoplasia (PanIN) Are Different from Those without High-Grade PanIN Reviewed International journal

    Tetsuyuki Miyazaki, Yoshihiro Ohishi, Yoshihiro Miyasaka, Yasunori Oda, Shinichi Aishima, Keigo Ozono, Atsushi Abe, Eishi Nagai, Masafumi Nakamura, Yoshinao Oda

    Pathobiology   84 ( 4 )   192 - 201   2017.7

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    DOI: 10.1159/000455194

  • HIF-1α, MDM2, CDK4, and p16 expression in ischemic fasciitis, focusing on its ischemic condition Reviewed International journal

    471 ( 1 )   117 - 122   2017.7

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    Ischemic fasciitis is a benign myofibroblastic lesion, occurring in the sacral region or proximal thigh of elderly or bedridden individuals. The pathogenesis of ischemic fasciitis is thought to be based on ischemic condition; however, it has never been demonstrated. In this study, we examined the expression of ischemia-associated proteins in ischemic fasciitis by immunohistochemical and genetic methods. Specifically, this study aimed to reveal the expression of HIF-1α, MDM2, CDK4, p16, and gene amplification of MDM2 gene. Seven cases of ischemic fasciitis from among the soft-tissue tumors registered at our institution were retrieved. Histopathological findings were as follows: poorly demarcated nodular masses, a proliferation of spindle-shaped fibroblastic or myofibroblastic cells with oval nuclei and eosinophilic or pale cytoplasm, zonal fibrinous deposition, pseudocystic degeneration, granulation-like proliferation of capillary vessels, ganglion-like cells, myxoid or hyalinized stroma, and chronic inflammatory infiltration. Immunohistochemically, the spindle cells were positive for HIF-1α (7/7 cases), MDM2 (4/7 cases), CDK4 (4/7 cases), p16 (7/7 cases), p53 (2/7 case), cyclin D1 (7/7 cases), and alpha-smooth muscle actin (6/7 cases). Neither MDM2 gene amplification nor USP6 gene split signal was detected in any case. Overexpression of the above proteins may be associated with the pathogenic mechanism of ischemic fasciitis. It is noted that the immunohistochemical positivity of MDM2, CDK4, and p16 do not necessarily indicate malignant neoplasm such as dedifferentiated liposarcoma.

    DOI: 10.1007/s00428-017-2122-2

  • Clinical implications of the novel cytokine IL-38 expressed in lung adenocarcinoma Possible association with PD-L1 expression Reviewed International journal

    Kazuki Takada, Tatsuro Okamoto, Masaki Tominaga, Koji Teraishi, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Gouji Toyokawa, Fumihiro Shoji, Masaki Okamoto, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara

    PLoS One   12 ( 7 )   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0181598

  • A exceptional collision tumor of primary adrenal angiosarcoma and non-functioning adrenocortical adenoma Reviewed International journal

    Katsumi Takizawa, Kenichi Kouhashi, Takahito Negishi, Kenichi Taguchi, Yuichi Yamada, Motonobu Nakamura, Yoshinao Oda

    Pathology Research and Practice   213 ( 6 )   702 - 705   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.prp.2017.04.017

  • Relevance Between Programmed Death Ligand 1 and Radiologic Invasiveness in Pathologic Stage I Lung Adenocarcinoma Reviewed International journal

    Gouji Toyokawa, Kazuki Takada, Tatsuro Okamoto, Satoshi Kawanami, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Masakazu Katsura, Yuichi Yamada, Fumihiro Shoji, Shingo Baba, Takeshi Kamitani, Yoshinao Oda, Hiroshi Honda, Yoshihiko Maehara

    Annals of Thoracic Surgery   103 ( 6 )   1750 - 1757   2017.6

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    DOI: 10.1016/j.athoracsur.2016.12.025

  • Programmed death-ligand 1 expression at tumor invasive front is associated with epithelial-mesenchymal transition and poor prognosis in esophageal squamous cell carcinoma Reviewed International journal

    Satoshi Tsutsumi, Hiroshi Saeki, Yuichiro Nakashima, Shuhei Ito, Eiji Oki, Masaru Morita, Yoshinao Oda, Shinji Okano, Yoshihiko Maehara

    Cancer Science   108 ( 6 )   1119 - 1127   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13237

  • Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma Reviewed International journal

    Yoshiki Asayama, Akihiro Nishie, Kosei Ishigami, yasuhiro ushijima, Yukihisa Takayama, Daisuke Okamoto, nobuhiro fujita, Ohtsuka Takao, Tomoharu Yoshizumi, Shinichi Aishima, Yoshinao Oda, Hiroshi Honda

    European Radiology   27 ( 6 )   2563 - 2569   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00330-016-4621-y

  • Low-grade intraductal carcinoma (low-grade cribriform cystadenocarcinoma) with tumor-associated lymphoid proliferation of parotid gland Reviewed International journal

    Toshimitsu Nishijima, Hidetaka Yamamoto, Takafumi Nakano, Yui Hatanaka, Ken ichi Taguchi, Muneyuki Masuda, Yoshinao Oda

    Pathology Research and Practice   213 ( 6 )   706 - 709   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.prp.2017.02.019

  • Isthmic-vaginal cytological findings after a trachelectomy for early-stage cervical cancer Reviewed International journal

    Kenzo Sonoda, H. Yahata, Okugawa Kaoru, Kaneki Eisuke, K. Nakatsuki, M. Naka, N. Terado, F. Ookubo, Yoshinao Oda, Tsunehisa Kaku, Kiyoko Kato

    Cytopathology   28 ( 3 )   243 - 245   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cyt.12379

  • Immunostaining for Hu C/D and CD56 is useful for a definitive histopathological diagnosis of congenital and acquired isolated hypoganglionosis Reviewed International journal

    Koichiro Yoshimaru, Tomoaki Taguchi, Satoshi Obata, Junkichi Takemoto, Yoshiaki Takahashi, Tsuyoshi Iwanaka, Yusuke Yanagi, Masaaki Kuda, kina miyoshi, Toshiharu Matsuura, Yoshiaki Kinoshita, Takako Yoshioka, Atsuko Nakazawa, Yoshinao Oda

    Virchows Archiv   470 ( 6 )   679 - 685   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00428-017-2128-9

  • High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer Reviewed International journal

    Sho Nishimura, Eiji Oki, Kouji Andou, Makoto Iimori, Yu Nakaji, Yuichiro Nakashima, Hiroshi Saeki, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   6 ( 6 )   1453 - 1464   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cam4.1090

  • Expression of protease-activated receptor-2 (PAR-2) is related to advanced clinical stage and adverse prognosis in ovarian clear cell carcinoma Reviewed International journal

    Murasaki Aman, Yoshihiro Ohishi, Hiroko Imamura, Tomoko Shinozaki, Nobuko Yasutake, Kiyoko Kato, Yoshinao Oda

    Human Pathology   64   156 - 163   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.humpath.2017.04.008

  • Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma Reviewed International journal

    Takeaki Ishii, Kenichi Kouhashi, Hiroshi Ootsuka, Kunio Iura, Akira Maekawa, Yuichi Yamada, Hirofumi Bekki, Masato Yoshimoto, Hidetaka Yamamoto, Yukihide Iwamoto, Yoshinao Oda

    Pathology Research and Practice   213 ( 6 )   634 - 638   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.prp.2017.04.022

  • Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma Reviewed International journal

    Huanlin Wang, Kenichi Kouhashi, Tomoharu Yoshizumi, Yukihiko Okumura, Yuki Tanaka, Masahiro Shimokawa, Takeshi Iwasaki, Shinichi Aishima, Yoshihiko Maehara, Yoshinao Oda

    Human Pathology   64   69 - 75   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.humpath.2017.03.007

  • Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors Reviewed International journal

    Hirofumi Bekki, Hidetaka Yamamoto, Katsumi Takizawa, Takeshi Iwasaki, Hiroshi Otsuka, Yuichi Yamada, Kenichi Kouhashi, Katsumi Harimaya, Yukihide Iwamoto, Yoshinao Oda

    Pathology Research and Practice   213 ( 6 )   674 - 679   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.prp.2016.12.001

  • Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice Reviewed International journal

    Sho Endo, Kohei Nakata, Kenoki Ouchida, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Kazuhiro Koikawa, Takashi Okumura, Masafumi Sada, Kohei Horioka, Biao Zheng, Yusuke Mizuuchi, Chika Iwamoto, Masaharu Murata, Taiki Moriyama, Yoshihiro Miyasaka, Ohtsuka Takao, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura

    Gastroenterology   152 ( 6 )   1492 - 1506.e24   2017.5

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    DOI: 10.1053/j.gastro.2017.01.010

  • The relationship between the expression of FOXA1 and GATA3 and the efficacy of neoadjuvant endocrine therapy Reviewed International journal

    Kimihiro Tanaka, Eriko Tokunaga, Nami Yamashita, Yasuaki Sagara, Yasuyo Ohi, Kenichi Taguchi, Shinji Ohno, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara

    Breast Cancer   24 ( 3 )   384 - 392   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12282-016-0714-3

  • Severe Aplastic Anemia during Osimertinib Therapy in a Patient with EGFR Tyrosine Kinase Inhibitor–Resistant Non–Small Cell Lung Cancer Reviewed International journal

    12 ( 5 )   e46 - e47   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jtho.2016.12.023

  • Primary extraskeletal osteosarcoma a clinicopathological study of 18 cases focusing on MDM2 amplification status Reviewed International journal

    Kyoko Yamashita, Kenichi Kouhashi, Yuichi Yamada, Yoshihiro Nishida, Hiroshi Urakawa, Yoshinao Oda, Shinya Toyokuni

    Human Pathology   63   63 - 69   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.humpath.2017.02.007

  • Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor Reviewed International journal

    Fukushima S, Endo M, Matsumoto Y, Fukushi JI, Matsunobu T, Kawaguchi KI, Setsu N, IIda K, Yokoyama N, Nakagawa M, Yahiro K, Oda Y, Iwamoto Y, Nakashima Y.

    PLoS One   12 ( 5 )   e0178064   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0178064

  • Phosphorylation of STAT3 in undifferentiated pleomorphic sarcoma is correlated with a favorable prognosis Reviewed International journal

    Hirofumi Bekki, Kenichi Kouhashi, Yuichi Yamada, Kunio Iura, Takeaki Ishii, Akira Maekawa, Hiroshi Otsuka, Hidetaka Yamamoto, Michiyuki Hakozaki, Kazuki Nabeshima, Yukihide Iwamoto, Yoshinao Oda

    Pathobiology   84 ( 3 )   161 - 169   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000448524

  • Molecular Evidence for Monoclonal Skip Progression in Main Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas Reviewed International journal

    Kenjiro Date, Ohtsuka Takao, Takaaki Fujimoto, Koji Tamura, Hideyo Kimura, Taketo Matsunaga, Naoki Mochidome, Tetsuyuki Miyazaki, Yasuhisa Mori, Yoshinao Oda, Masafumi Nakamura, Masao Tanaka

    Annals of Surgery   265 ( 5 )   969 - 977   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/SLA.0000000000001755

  • Clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer Reviewed International journal

    Toshiya Abe, Kenoki Ouchida, Sho Endo, Fumihiko Ookubo, Yasuhisa Mori, Kohei Nakata, Yoshihiro Miyasaka, Tatsuya Manabe, Ohtsuka Takao, Eishi Nagai, Yoshinao Oda, Masafumi Nakamura

    Surgery   161 ( 4 )   951 - 958   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.surg.2016.10.035

  • Oncogenic roles of SMARCB1/INI1 and its deficient tumors Reviewed International journal

    Kenichi Kouhashi, Yoshinao Oda

    Cancer Science   108 ( 4 )   547 - 552   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13173

  • Long-term outcomes of type I thyroplasty with silicone implantation Assessment of excised laryngeal tissue from a patient with secondary hypopharyngeal carcinoma Reviewed International journal

    Kazuo Adachi, Toshiro Umezaki, Toshimitsu Nishijima, Hidetaka Yamamoto, Yoshinao Oda

    Auris Nasus Larynx   44 ( 2 )   245 - 248   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.anl.2016.07.007

  • Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes Reviewed International journal

    Yuichi Yamada, Masaaki Kuda, Kenichi Kouhashi, Hidetaka Yamamoto, Junkichi Takemoto, Takeaki Ishii, Kunio Iura, Akira Maekawa, Hirofumi Bekki, Takamichi Ito, Hiroshi Otsuka, Makoto Kuroda, Yumi Honda, Shinji Sumiyoshi, Takeshi Inoue, Naoe Kinoshita, Atsushi Nishida, Kyoko Yamashita, Ichiro Ito, Shizuo Komune, Tomoaki Taguchi, Yukihide Iwamoto, Yoshinao Oda

    Virchows Archiv   470 ( 4 )   373 - 380   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00428-017-2072-8

  • Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients with Suspected Insulinoma Reviewed International journal

    Keijiro Ueda, Ken Kawabe, Lingaku Lee, Yuichi Tachibana, Nao Fujimori, Hisato Igarashi, Yoshinao Oda, Robert T. Jensen, Ryoichi Takayanagi, Tetsuhide Ito

    Pancreas   46 ( 4 )   476 - 481   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MPA.0000000000000772

  • Cancer-testis antigen expression in synovial sarcoma: NY-ESO-1, PRAME, MAGEA4, and MAGEA1 Reviewed International journal

    HUMAN PATHOLOGY   61   130 - 139   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.humpath.2016.12.006

  • Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor Reviewed

    Fukushima S, Endo M, Matsumoto Y, Fukushi JI, Matsunobu T, Kawaguchi KI, Setsu N, IIda K, Yokoyama N, Nakagawa M, Yahiro K, Oda Y, Iwamoto Y, Nakashima Y.

    PLoS One.   12 ( 5 )   e0178064   2017.3

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    DOI: doi: 10.1371/journal.pone.0178064.

  • Elevated metabolic activity on 18f-fdg pet/ct is associated with the expression of ezh2 in non-small cell lung cancer Reviewed

    Gouji Toyokawa, Kazuki Takada, Tatsuro Okamoto, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Fumihiro Shoji, Ryuji Hamamoto, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   37 ( 3 )   1393 - 1401   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.11461

  • Computed Tomography Features of Lung Adenocarcinomas With Programmed Death Ligand 1 Expression. Reviewed International journal

    Toyokawa G, Takada K, Okamoto T, Shimokawa M, Kozuma Y, Matsubara T, Haratake N, Takamori S, Akamine T, Katsura M, Shoji F, Oda, Y, Maehara,Y

    Clin Lung Cancer   2017.3

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  • Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells Reviewed International journal

    Okumura, Takashi, Ohuchida, Kenoki, Sada, Masafumi, Abe, Toshiya, Endo, Sho, Koikawa, Kazuhiro, Iwamoto, Chika, Miura, Daisuke, Mizuuchi, Yusuke, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Manabe, Tatsuya, Ohtsuka, Takao, Nagai, Eishi, Mizumoto, Kazuhiro, Oda, Yoshinao, Hashizume, Makoto, Nakamura, Masafumi

    ONCOTARGET   8 ( 11 )   18280 - 18295   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.15430

  • Tropomyosin-related kinase B mediated signaling contributes to the induction of malignant phenotype of gallbladder cancer. Reviewed International journal

    Kawamoto M, Onishi H, Ozono K, Yamasaki A, Imaizumi A, Kamakura S, Nakano K, Oda, Y, Sumimoto H, Nakamura M

    Oncotarget.   8 ( 22 )   36211 - 36224   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.16063

  • A Comprehensive Analysis of Programmed Cell Death Ligand-1 Expression With the Clone SP142 Antibody in Non-Small-Cell Lung Cancer Patients. Reviewed International journal

    Takada K, Toyokawa G, Okamoto T, Shimokawa M, Kozuma Y, Matsubara T, Haratake N, Akamine T, Takamori S, Katsura M, Shoji F, Oda, Y, Maehara Y

    Clinical Lung Cancer   2017.3

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  • Immunohistochemical detection of MTAP and BAP1 protein loss for mesothelioma diagnosis: Comparison with 9p21 FISH and BAP1 immunohistochemistry Reviewed International journal

    Hida T, Hamasaki M, Matsumoto S, Sato A, Tsujimura T, Kawahara K, Iwasaki A, Okamoto T, Oda, Y, Honda H, Nabeshima K

    LUNG CANCER   104   98 - 105   2017.2

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    DOI: 10.1016/j.lungcan.2016.12.017

  • Tissue classification of liver pathological tissue specimens image using spectral features Reviewed

    E. Hashimoto, M. Ishikawa, K. Shinoda, M. Hasegawa, H. Komagata, N. Kobayashi, N. Mochidome, Yoshinao Oda, C. Iwamoto, Kenoki Ouchida, M. Hashizume

    SPIE Medical Imaging 2017 Proceedings of SPIE - The International Society for Optical Engineering   10327   2017.2

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  • The expression of PD-L1 protein as a prognostic factor in lung squamous cell carcinoma Reviewed

    Kazuki Takada, Tatsuro Okamoto, Gouji Toyokawa, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Fumihiro Shoji, Yoshinao Oda, Yoshihiko Maehara

    Lung Cancer   104   7 - 15   2017.2

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    DOI: 10.1016/j.lungcan.2016.12.006

  • The combination of PD-L1 expression and decreased tumor-infiltrating lymphocytes is associated with a poor prognosis in triple-negative breast cancer Reviewed International journal

    Mori, Hitomi, Kubo, Makoto, Yamaguchi, Rin, Nishimura, Reiki, Osako, Tomofumi, Arima, Nobuyuki, Okumura, Yasuhiro, Okido, Masayuki, Yamada, Mai, Kai, Masaya, Kishimoto, Junji, Oda, Y, Nakamura, Masafumi

    ONCOTARGET   8 ( 9 )   15584 - 15592   2017.2

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    DOI: 10.18632/oncotarget.14698

  • Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body Reviewed International journal

    Bai Xiaopeng, Tanaka, Yoshimasa, Ihara, Eikichi, Hirano, Katsuya, Nakano, Kayoko, Hirano, Mayumi, Oda, Yoshinao, Nakamura, Kazuhiko

    EUROPEAN JOURNAL OF PHARMACOLOGY   797   65 - 74   2017.2

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    DOI: 10.1016/j.ejphar.2017.01.004

  • Mass-forming intrahepatic cholangiocarcinoma: Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings Reviewed International journal

    Fujita, Nobuhiro, Asayama, Yoshiki, Nishie, Akihiro, Ishigami, Kousei, Ushijima, Yasuhiro, Takayama, Yukihisa, Okamoto, Daisuke, Moirta, Koichiro, Shirabe, Ken, Aishima, Shinichi, Wang, Huanlin, Oda, Yoshinao, Honda, Hiroshi

    EUROPEAN RADIOLOGY   27 ( 2 )   498 - 506   2017.2

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    DOI: 10.1007/s00330-016-4386-3

  • Elevated bile amylase level without pancreaticobiliary maljunction is a risk factor for gallbladder carcinoma Reviewed International journal

    Fujimoto, Takaaki, Ohtsuka, Takao, Nakashima, Yohei, Gotoh, Yoshitaka, Date, Kenjiro, Mori, Yasuhisa, Sadakari, Yoshihiko, Takahata, Shunichi, Oda, Yoshinao, Nakamura, Masafumi

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   24 ( 2 )   103 - 108   2017.2

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    DOI: 10.1002/jhbp.421

  • FOXO3a Expression Regulated by ERK Signaling is Inversely Correlated With Y-Box Binding Protein-1 Expression in Prostate Cancer Reviewed International journal

    Imada, Kenjiro, Shiota, Masaki, Kuroiwa, Kentaro, Sugimoto, Masaaki, Abe, Tatsuro, Kohashi, Kenichi, Yokomizo, Akira, Eto, Masatoshi, Naito, Seiji, Oda, Yoshinao

    PROSTATE   77 ( 2 )   145 - 153   2017.2

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    DOI: 10.1002/pros.23254

  • Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma Reviewed International journal

    Akiyama, Shingo, Saeki, Hiroshi, Nakashima, Yuichiro, Iimori, Makoto, Kitao, Hiroyuki, Oki, Eiji, Oda Yoshinao, Nakabeppu, Yusaku, Kakeji, Yoshihiro, Maehara, Yoshihiko

    Auris Nasus Larynx   6 ( 1 )   258 - 266   2017.1

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    DOI: 10.1002/cam4.979

  • Undifferentiated/unclassified sarcoma in the lung A case report Reviewed

    Naoki Date, Tsuyoshi Shoji, Yusuke Wakatsuki, Yuichi Yamada, Yoshinao Oda, Hiromichi Katakura

    Japanese Journal of Lung Cancer   57 ( 7 )   866 - 869   2017.1

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    DOI: 10.2482/haigan.57.866

  • The incidence and outcome of allied disorders of Hirschsprung's disease in Japan Results from a nationwide survey Reviewed

    Tomoaki Taguchi, Satoshi Ieiri, Kina Miyoshi, Kenichi Kohashi, Yoshinao Oda, Akio Kubota, Yoshio Watanabe, Hiroshi Matsufuji, Masahiro Fukuzawa, Takeshi Tomomasa

    Asian Journal of Surgery   40 ( 1 )   29 - 34   2017.1

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    DOI: 10.1016/j.asjsur.2015.04.004

  • Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producingadvanced gastric neuroendocrine carcinoma Reviewed

    Nobuhiro Tsuruta, Kotoe Takayoshi, Shuji Arita, Tomomi Aikawa, Hiroshi Ariyama, Hitoshi Kusaba, Kenoki Ohuchida, Eishi Nagai, Kenichi Kohashi, Minako Hirahashi, Kyoko Inadomi, Mamoru Tanaka, Kosuke Sagara, Yuta Okumura, Kenta Nio, Michitaka Nakano, Masafumi Nakamura, Yoshinao Oda, Koichi Akashi, Eishi Baba

    Oncology Letters   14 ( 2 )   1500 - 1504   2017.1

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    DOI: 10.3892/ol.2017.6299

  • Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint Reviewed

    Takashi Hatano, Masanobu Ohishi, Goichi Yoshimoto, Moriyasu Yamauchi, Akira Maekawa, Hidetaka Yamamoto, Yoshinao Oda, Makoto Endo, Hirofumi Bekki, Tomoya Matsunobu, Yasuharu Nakashima, Ken Okazaki, Jun Ichi Fukushi, Akiko Oyamada, Yukihide Iwamoto

    JBJS case connector   7 ( 3 )   2017.1

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    DOI: 10.2106/JBJS.CC.17.00002

  • Endocervical adenocarcinoma with morphologic features of both usual and gastric types clinicopathologic and immunohistochemical analyses and high-risk hpv detection by in situ hybridization Reviewed

    Tomoko Wada, Yoshihiro Ohishi, Tsunehisa Kaku, Murasaki Aman, Hiroko Imamura, Nobuko Yasutake, Kenzo Sonoda, Kiyoko Kato, Yoshinao Oda

    American Journal of Surgical Pathology   41 ( 5 )   696 - 705   2017.1

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    DOI: 10.1097/PAS.0000000000000833

  • Duodenal Neoplasms of Gastric Phenotype An Immunohistochemical and Genetic Study with a Practical Approach to the Classification Reviewed

    Risa Hida, Hidetaka Yamamoto, Minako Hirahashi, Reiko Kumagai, Kenichi Nishiyama, Toshihiro Gi, Motohiro Esaki, Takanari Kitazono, Yoshinao Oda

    American Journal of Surgical Pathology   41 ( 3 )   343 - 353   2017.1

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    DOI: 10.1097/PAS.0000000000000785

  • Degree of desmoplasia in metastatic lymph node lesions is associated with lesion size and poor prognosis in pancreatic cancer patients Reviewed

    Hiromichi Nakayama, Kenoki Ohuchida, Masaki Yoshida, Tetsuyuki Miyazaki, Shin Takesue, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Takashi Okumura, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Kengo Shirahane, Tatsuya Manabe, Takao Ohtsuka, Hiroki Toma, Yohei Tominaga, Eishi Nagai, Kazuhiro Mizumoto, Yoshinao Oda, Masafumi Nakamura

    Oncology Letters   14 ( 3 )   3141 - 3147   2017.1

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    DOI: 10.3892/ol.2017.6549

  • A case of undifferentiated pleomorphic sarcoma originally diagnosed as dedifferentiated liposarcoma Reviewed

    Reiko Miyazaki, Hiroshi Uchi, Takamichi Ito, Takeaki Ishii, Yuichi Yamada, Yoshinao Oda, Masutaka Furue

    Nishinihon Journal of Dermatology   79 ( 1 )   46 - 49   2017.1

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    DOI: 10.2336/nishinihonhifu.79.46

  • PD-L1 expression in papillary renal cell carcinoma Reviewed International journal

    Motoshima, Takanobu, Komohara, Yoshihiro, Ma, Chaoya, Dewi, Arni Kusuma, Noguchi, Hirotsugu, Yamada, Sohsuke, Nakayama, Toshiyuki, Kitada, Shohei, Kawano, Yoshiaki, Takahashi, Wataru, Sugimoto, Masaaki, Fujimoto, Naohiro, Oda, Yoshinao, Eto, Masatoshi

    BMC Urology   17   2017.1

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    DOI: 10.1186/s12894-016-0195-x

  • Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma Reviewed International journal

    Akiyama, Shingo, Saeki, Hiroshi, Nakashima, Yuichiro, Iimori, Makoto, Kitao, Hiroyuki, Oki, Eiji, Oda, Y, Nakabeppu, Yusaku, Kakeji, Yoshihiro, Maehara, Yoshihiko

    CANCER MEDICINE   6 ( 1 )   258 - 266   2017.1

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    DOI: 10.1002/cam4.979

  • Solid Pseudopapillary Neoplasm of the Pancreas in Young Male Patients: Three Case Reports. Reviewed International journal

    Aso A, Ihara E, Nakamura K, Sudovykh I, Ito T, Nakamura M, Ikeda T, Takizawa N, Oda, Y, Shimizu S

    Case Rep Gastrointest Med   2017.1

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  • Prognostic value of BRAF V600E mutation and microsatellite instability in Japanese patients with sporadic colorectal cancer Reviewed International journal

    Nakaji, Yu, Oki, Eiji, Nakanishi, Ryota, Ando, Koji, Sugiyama, Masahiko, Nakashima, Yuichiro, Yamashita, Nami, Saeki, Hiroshi, Oda, Y, Maehara, Yoshihiko

    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY   143 ( 1 )   151 - 160   2017.1

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    DOI: 10.1007/s00432-016-2275-4

  • Cardiac metastasis of squamous cell carcinoma of the thyroid gland with severe disseminated intravascular coagulation: A case report. Reviewed International journal

    Yoshihiro T, Tsuchihashi K, Kusaba H, Nakashima T, Obara T, Nio K, Takayoshi K, Kodama H, Tsuruta N, Kiyohara H, Asai K, Harada E, Kamezaki K,Arita T,Sato M, Yamamoto H, Arita S, Ariyama H, Harada E, Oda, Y, Akashi K

    Mol Clin Oncol   6 ( 1 )   91 - 95   2017.1

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  • BRCAness as a Biomarker for Predicting Prognosis and Response to Anthracycline-Based Adjuvant Chemotherapy for Patients with Triple-Negative Breast Cancer Reviewed International journal

    Mori, Hitomi, Kubo, Makoto, Nishimura, Reiki, Osako, Tomofumi, Arima, Nobuyuki, Okumura, Yasuhiro, Okido, Masayuki, Yamada, Mai, Kai, Masaya, Kishimoto, Junji, Miyazaki, Tetsuyuki, Oda Yoshinao, Nakamura, Masafumi

    JAPANESE JOURNAL OF RADIOLOGY   11 ( 12 )   2016.12

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    DOI: 10.1371/journal.pone.0167016

  • CD146 attenuation in cancer-associated fibroblasts promotes pancreatic cancer progression. Reviewed International journal

    Zheng B, Ohuchida K, Chijiiwa Y, Zhao M, Mizuuchi Y, Cui L, Horioka K, Ohtsuka T, Mizumoto K, Oda, Yoshinao, Hashizume M, Nakamura M, Tanaka M

    Mol Carcinog.   55 ( 11 )   1560 - 1572   2016.12

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  • Molecular Factors Associated with Pemetrexed Sensitivity According to Histological Type in Non-small Cell Lung Cancer Reviewed International journal

    Yoshida, Tsukihisa, Okamoto, Tatsuro, Yano, Tokujiro, Takada, Kazuki, Kohno, Mikihiro, Suda, Kenichi, Takenoyama, Mitsuhiro, Oda, Yoshinao, Maehara, Yoshihiko

    ANTICANCER RESEARCH   36 ( 12 )   6319 - 6326   2016.12

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    DOI: 10.21873/anticanres.11228

  • High Frequency of Programmed Death-ligand 1 Expression in Emphysematous Bullae-associated Lung Adenocarcinomas. Reviewed International journal

    Toyokawa G, Takada K, Okamoto T, Kozuma Y, Matsubara T, Haratake N, Takamori S, Akamine T, Katsura M, Shoji F, Oda, Y, Maehara Y

    Clin Lung Cancer.   2016.12

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  • Impact of the expression of vimentin and Axl in breast cancer. Reviewed International journal

    Tanaka K, Tokunaga E, Inoue Y, Yamashita N, Saeki H, Okano S, Kitao H, Oki E, Oda, Yoshinao

    Clinical Breast Cancer   16 ( 6 )   520 - 526   2016.12

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  • Prognostic Significance of Expression of the Epithelial-Mesenchymal Transition-Related Factor Brachyury in Intrathoracic Lymphatic Spread of Non-Small Cell Lung Cancer Reviewed International journal

    Shimamatsu, Shinichiro, Okamoto, Tatsuro, Haro, Akira, Kitahara, Hirokazu, Kohno, Mikihiro, Morodomi, Yosuke, Tagawa, Tetsuzo, Okano, Shinji, Oda, Yoshinao, Maehara, Yoshihiko

    ANNALS OF SURGICAL ONCOLOGY   23   S1012 - S1020   2016.12

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    DOI: 10.1245/s10434-016-5530-7

  • High expression of the Notch ligand Jagged-1 is associated with poor prognosis after surgery for colorectal cancer. Reviewed International journal

    Sugiyama M, Oki E, Nakaji Y, Tsutsumi S, Ono N, Nakanishi R, Sugiyama M, Nakashima Y, Sonoda H, Ohgaki K, Yamashita N, Saeki H, Okano S, Kitao H, Morita M, Oda, Yoshinao, Maehara Y.

    Cancer Sci.   107 ( 11 )   1705 - 1716   2016.11

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  • Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1α and malignant potential in pancreatic neuroendocrine tumors Reviewed

    12 ( 5 )   3337 - 3343   2016.11

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    The present study aimed to investigate the prognostic usefulness of the expression of glucose transporter type 1 (GLUT-1) and GLUT-2, hypoxia-inducible factor 1α (HIF-1α) and insulin-like growth factor II messenger RNA-binding protein 3 (IMP3) in pancreatic neuroendocrine tumors (pNETs). Immunohistochemical