2025/01/17 更新

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写真a

オダ ヨシナオ
小田 義直
ODA YOSHINAO
所属
医学研究院 附属ヒト疾患モデル研究センター 教授
九州大学病院 病理部(併任)
医学研究院 附属ヒト疾患モデル研究センター(併任)
医学部 生命科学科(併任)
医学系学府 医学専攻(併任)
医学系学府 医療経営・管理学専攻(併任)
職名
教授
連絡先
メールアドレス
電話番号
0926426061
プロフィール
【研究業績】 骨軟部腫瘍の外科病理、骨軟部腫瘍の薬剤耐性遺伝子、癌遺伝子、および癌抑制遺伝子に関する分子病理学研究に従事し、それらの研究成果を論文等に執筆する一方、外科病理の知識を生かし臨床科との協同研究も行っている。 【教育活動】 医学部学生の分子病理および外科病理の講義、病材示説、病理標本の実習を担当。医学研究院大学院生の分子病理学的解析法の教育も担当。 【社会連携活動】 地域基幹病院、検査センター等の病理標本の診断を行い、外科病理の知識を地域に還元する。日本病理学会理事長、国際病理アカデミー日本支部会長を務め学会活動に貢献している
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学位

  • 医学博士

経歴

  • 佐賀県立病院好生館 1987.6--1988.5 九州厚生年金病院 1996.6--1999.9

    佐賀県立病院好生館 1987.6--1988.5 九州厚生年金病院 1996.6--1999.9

研究テーマ・研究キーワード

  • 研究テーマ:空間的マルチオミクス解析による軟部肉腫の腫瘍微小環境の解明と代謝標的治療法の探索

    研究キーワード:軟部肉腫、腫瘍微小環境、空間的マルチオミクス解析、腫瘍代謝

    研究期間: 2023年5月 - 2023年8月

  • 研究テーマ:悪性骨軟部腫瘍における腫瘍免疫に関わる新規バイオマーカの探索

    研究キーワード:悪性骨軟部腫瘍、腫瘍免疫、バイオマーカー

    研究期間: 2016年4月 - 2020年6月

  • 研究テーマ:転座関連および非転座関連悪性軟部腫瘍における分子標的の網羅的探索

    研究キーワード:悪性軟部腫瘍、染色体転座

    研究期間: 2013年4月 - 2016年3月

  • 研究テーマ:悪性軟部腫瘍におけるシグナル伝達分子異常の解析と分子標的治療の可能性の研究

    研究キーワード:悪性軟部腫瘍、mTOR, STAT3, pAkt

    研究期間: 2009年5月 - 2012年5月

  • 研究テーマ:悪性骨軟部腫瘍におけるケモカインレセプターと血管新生

    研究キーワード:悪性骨軟部腫瘍、VEGF, CXCR4

    研究期間: 2006年4月 - 2009年5月

  • 研究テーマ:悪性骨軟部腫瘍における細胞周期制御遺伝子および蛋白発現の研究

    研究キーワード:悪性骨軟部腫瘍、細胞周期制御遺伝子、細胞周期制御蛋白

    研究期間: 2003年4月

  • 研究テーマ:軟部肉腫における分子生物学的予後因子の研究

    研究キーワード:軟部肉腫、分子病理、予後因子

    研究期間: 2000年4月 - 2002年3月

  • 研究テーマ:ヒト悪性固形腫瘍における多剤耐性遺伝子の発現

    研究キーワード:悪性骨軟部腫瘍、婦人科腫瘍、小児腫瘍、多剤耐性遺伝子、分子生物学

    研究期間: 1996年10月 - 2003年12月

受賞

  • 2021年度国際会議誘致・開催貢献賞 国際会議誘致の部

    2022年2月   日本政府観光局   第36回国際病理アカデミー国際会議を福岡に誘致した業績による(2026年10月開催予定)

  • 日本病理学賞

    2016年5月   日本病理学会   軟部肉腫の病理病態―形態から分子生物学的アプローチへ

  • International Academy of Pathology 日本支部 2002年病理診断学術奨励賞

    2002年11月   International Academy of Pathology 日本支部   Pleomorphic Leiomyosarcomaの臨床病理学的研究

  • 日本病理学会学術研究賞(A演説)(平成13年)

    2001年11月   日本病理学会  

  • 日本病理学会学術奨励賞

    2000年4月   日本病理学会   滑膜肉腫における分子病理学的研究

論文

  • Dysadherin expression as a significant prognostic factor and as a determinant of histological features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression. 査読 国際誌

    Izumi T, Oda Y, Hasegawa T, Kawai A, Sonobe H, Nakanishi Y, Takahira T, Kobayashi C, Yamamoto H, Tamiya S, Yokoyama R, Hirohashi S, Iwamoto Y, Tsuneyoshi M

    Am J Surg Pathol 31; 85-94, 2007. (Corresponding)   2007年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: Analysis within a group of patients, all of whom developed lung metastasis. 査読 国際誌

    Oda Y, Yamamoto H, Tamiya S, Matsuda S, Tanaka K, Yokoyama R, Iwamoto Y, Tsuneyoshi M:

    Mod Pathol 19: 738-45, 2006. (corresponding)   2006年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Frequent alteration of p16INK4a/p14ARF and p53 pathways of round cell appearance in myxoid/round cell liposarcoma: Altered p53 gene and reduced p14ARF expression correlates with poor prognosis. 査読 国際誌

    Oda Y, Yamamoto H, Takahira T, Kobayashi C, Kawaguchi K, Tateishi N, Nozuka Y, Tamiya S, Tanaka K, Matsuda S, Yokoyama R, Iwamoto Y, Tsuneyoshi M:

    J Pathol 207; 410-421, 2005. (Corresponding)   207 ( 4 )   410 - 421   2005年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/path.1848

  • ATP-binding cassette superfamily transporter gene expression in human soft tissue sarcoma. 査読 国際誌

    Oda Y, Saito T, Tateishi N, Ohishi Y, Tamiya S, Yamamoto H, Yokoyama R, Uchiumi T, Iwamoto Y, Kuwano M, Tsuneyoshi M

    Int J Cancer 114: 854-862, 2005 (Corresponding)   114 ( 6 )   854 - 862   2005年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ijc.20589

  • Low-grade fibromyxoid sarcoma versus low-grade myxofibrosarcoma in the extremities and trunk. Clinicopathologic and immunohistochemical study with special emphasis on the alteration of cell cycle regulators. 査読 国際誌

    Oda Y, Takahira T, Kawaguchi K, Yamamoto H, Tamiya S, Matsuda S, Tanaka K,wamoto Y, Tsuneyoshi M:

    Histopathology 45; 29-38, 2004 (Corresponding)   45 ( 1 )   29 - 38   2004年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1365-2559.2004.01886.x

  • E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma. 査読 国際誌

    Saito T, Oda Y, Kawaguchi K, Yamamoto H, Sugimachi K, Tateishi N, Tanaka K,Matsuda S, Iwamoto Y, Ladanyi M, Tsuneyoshi M:

    Oncogene 23: 8629-8638, 2004   23 ( 53 )   8629 - 8638   2004年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/sj.onc.1207960

  • Nuclear expression of Y box-binding protein-1 correlates with P-glycoprotein and topoisomerase II-apha expression, and poor prognosis in synovial sarcoma. 査読 国際誌

    Oda Y, Ohishi Y, Saito T, Hinoshita E, Uchiumi T, Kinukawa N, Iwamoto Y, Kohno K, Kuwano M, Tsuneyoshi M

    J Pathol 199; 251-258, 2003   199 ( 2 )   251 - 258   2003年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/path.1282

  • Alterations of cell cycle regulators in myxofibrosarcoma. With special emphasis on their prognostic implications. 査読 国際誌

    Oda Y, Takahira T, Kawaguchi K, Yamamoto H, Tamiya S, Matsuda S, Tanaka K, Kinukawa N, Iwamoto Y, Tsuneyoshi M:

    Human Pathol 34; 1035-1042, 2003   2003年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Reassessment of malignant fibrous histiocytoma of soft parts and its clinicopathologic prognostic factors. 査読 国際誌

    Oda Y, Tamiya S, Oshiro Y, Hachitanda Y, Kinukawa N, Iwamoto Y, Tsuneyoshi M

    Pathol Int 52; 595-606, 2002   2002年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • ATP-binding casstte superfamily transporter gene expression in human ovarian carcinoma 査読 国際誌

    Ohishi Y, Oda Y, Uchiumi T, Kobayashi H, Hirakawa T, Miyamoto S, Kinukawa N, Nakano H, Kuwano M, Tsuneyoshi M:

    Clin Cancer Res 8; 3767-3775, 2002   8 ( 12 )   3767 - 3775   2002年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Pleomorphic leiomyosarcoma: Clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma. 査読 国際誌

    Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M

    Am J Surg Pathol 25; 1030-1038, 2001   25 ( 8 )   1030 - 1038   2001年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/00000478-200108000-00007

  • Molecular abnormalities of p53, MDM2 and H-ras in synovial sarcoma. 査読 国際誌

    Oda Y, Sakamoto A, Saito T, Kawauchi S, Iwamoto Y, Tsuneyoshi M:

    Mod Pathol 13: 994-1004, 2000.   13 ( 9 )   994 - 1004   2000年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/modpathol.3880180

  • Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma. 査読 国際誌

    Oda Y, Sakamoto A, Shinohara N, Ohga T, Uchiumi T, Kohno K, Tsuneyoshi M, Kuwano M, Iwamoto Y

    Clin Cancer Res 4: 2273-2277, 1998   4 ( 9 )   2273 - 2277   1998年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • TIM3 on natural killer cells regulates antibody-dependent cellular cytotoxicity in HER2-positive gastric cancer

    Tsutsumi C., Ohuchida K., Tsutsumi H., Shimada Y., Yamada Y., Son K., Hayashida S., Katayama N., Mochida Y., Iwamoto C., Torata N., Horioka K., Shindo K., Mizuuchi Y., Ikenaga N., Nakata K., Ota K., Iwama E., Yamamoto M., Tsukamoto T., Nomura S., Morisaki T., Oda Y., Okamoto I., Nakamura M.

    Cancer Letters   611   217412   2025年2月   ISSN:03043835

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    記述言語:英語   出版者・発行元:Cancer Letters  

    Therapies targeting HER2 are the standard treatment for HER2-positive gastric cancer (GC). Trastuzumab, a monoclonal antibody against HER2, exerts anti-tumor activity through cell growth regulation and antibody-dependent cellular cytotoxicity (ADCC). ADCC is induced by the binding of trastuzumab to Fcγ receptor III (CD16) in natural killer (NK) cells. However, the relationship between immune checkpoint (IC) molecules of NK cells and trastuzumab-induced ADCC is poorly understood. We performed single-cell RNA sequencing (scRNA-seq) and immunohistochemistry to identify IC molecules associated with CD16 expression in NK cells of GC patients. Additionally, we conducted in vitro assays with HER2-transfected GC cells and in vivo experiments using a mouse HER2-positive GC model to assess expression changes in IC molecules in NK cells and their ligands during trastuzumab treatment. In GC patients, the expression of TIM3, an IC molecule, was strongly correlated with that of CD16 in NK cells. In vitro assays showed that ADCC with trastuzumab increased TIM3 expression in NK cells. scRNA-seq analysis revealed that TIM3 expression of cytotoxic NK cells was elevated in HER2-positive GC patients treated with trastuzumab. HMGB1, a TIM3 ligand, was expressed at higher levels in HER2-transfected GC cells than in controls. Furthermore, HMGB1 expression was higher in HER2-positive GC patients treated with trastuzumab compared to untreated HER2-positive GC patients. In the mouse HER2-positive GC model, anti-TIM3 antibodies and trastuzumab demonstrated synergistic anti-tumor effects without toxicity. This study suggests the combined anti-TIM3 antibody and trastuzumab therapy may have potential as a new treatment strategy for HER2-positive GC.

    DOI: 10.1016/j.canlet.2024.217412

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  • Impact of the distance of spread through air spaces in non-small cell lung cancer.

    Hashinokuchi A, Akamine T, Toyokawa G, Matsudo K, Nagano T, Kinoshita F, Kohno M, Tomonaga T, Kohashi K, Shimokawa M, Oda Y, Takenaka T, Yoshizumi T

    Interdisciplinary cardiovascular and thoracic surgery   40 ( 1 )   2024年12月

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    記述言語:英語  

    DOI: 10.1093/icvts/ivae181

    PubMed

  • Exploring the tumor microenvironment of colorectal cancer patients post renal transplantation by single-cell analysis. 査読

    Zhang J, Mizuuchi Y, Ohuchida K, Hisano K, Shimada Y, Katayama N, Tsutsumi C, Tan BC, Nagayoshi K, Tamura K, Fujimoto T, Ikenaga N, Nakata K, Oda Y, Nakamura M

    Cancer science   2024年12月   ISSN:1347-9032

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    記述言語:英語  

    DOI: 10.1111/cas.16409

    PubMed

  • Tumor-associated neutrophils upregulate Nectin2 expression, creating the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

    Luo H., Ikenaga N., Nakata K., Higashijima N., Zhong P., Kubo A., Wu C., Tsutsumi C., Shimada Y., Hayashi M., Oyama K., Date S., Abe T., Ideno N., Iwamoto C., Shindo K., Ohuchida K., Oda Y., Nakamura M.

    Journal of Experimental and Clinical Cancer Research   43 ( 1 )   258   2024年12月   ISSN:0392-9078

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    記述言語:英語   出版者・発行元:Journal of Experimental and Clinical Cancer Research  

    Background: Tumor-associated neutrophils (TANs) constitute an abundant component among tumor-infiltrating immune cells and have recently emerged as a critical player in pancreatic ductal adenocarcinoma (PDAC) progression. This study aimed to elucidate the pro-tumor mechanisms of TAN and identify a novel target for effective immunotherapy against PDAC. Methods: Microarray and cytokine array analyses were performed to identify the mechanisms underlying the function of TANs. Human and mouse TANs were obtained from differentiated HL-60 cells and orthotopically transplanted PDAC tumors, respectively. The interactions of TANs with cancer and cytotoxic T-cells were evaluated through in vitro co-culture and in vivo orthotopic or subcutaneous models. Single-cell transcriptomes from patients with PDAC were analyzed to validate the cellular findings. Results: Increased neutrophil infiltration in the tumor microenvironment was associated with poor survival in patients with PDAC. TANs secreted abundant amounts of chemokine ligand 5 (CCL5), subsequently enhancing cancer cell migration and invasion. TANs subpopulations negatively correlated with cytotoxic CD8+ T-cell infiltration in PDAC and promoted T-cell dysfunction. TANs upregulated the membranous expression of Nectin2, which contributed to CD8+ T-cell exhaustion. Blocking Nectin2 improved CD8+ T-cell function and suppressed tumor progression in the mouse model. Single-cell analysis of human PDAC revealed two immunosuppressive TANs phenotypes: Nectin2+ TANs and OLR1+ TANs. Endoplasmic reticulum stress regulated the protumor activities in TANs. Conclusions: TANs enhance PDAC progression by secreting CCL5 and upregulating Nectin2. Targeting the immune checkpoint Nectin2 could represent a novel strategy to enhance immunotherapy efficacy in PDAC.

    DOI: 10.1186/s13046-024-03178-6

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  • Spatial dynamics of CD39<sup>+</sup>CD8<sup>+</sup> exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer 査読

    Tanoue K., Ohmura H., Uehara K., Ito M., Yamaguchi K., Tsuchihashi K., Shinohara Y., Lu P., Tamura S., Shimokawa H., Isobe T., Ariyama H., Shibata Y., Tanaka R., Kusaba H., Esaki T., Mitsugi K., Kiyozawa D., Iwasaki T., Yamamoto H., Oda Y., Akashi K., Baba E.

    Nature Communications   15 ( 1 )   9033   2024年12月

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    記述言語:英語   出版者・発行元:Nature Communications  

    Despite the success of immune checkpoint blockade (ICB) therapy for esophageal squamous cell cancer, the key immune cell populations that affect ICB efficacy remain unclear. Here, imaging mass cytometry of tumor tissues from ICB-treated patients identifies a distinct cell population of CD39+PD-1+CD8+ T cells, specifically the TCF1+ subset, precursor exhausted T (CD39+ Tpex) cells, which positively correlate with ICB benefit. CD39+ Tpex cells are predominantly in the stroma, while differentiated CD39+ exhausted T cells are abundantly and proximally within the parenchyma. Notably, CD39+ Tpex cells are concentrated within and around tertiary lymphoid structure (TLS). Accordingly, tumors harboring TLSs have more of these cells in tumor areas than tumors lacking TLSs, suggesting Tpex cell recruitment from TLSs to tumors. In addition, circulating CD39+ Tpex cells are also increased in responders following ICB therapy. Our findings show that this unique subpopulation of CD39+PD-1+CD8+ T cells is crucial for ICB benefit, and suggest a key role in TLS-mediated immune responses against tumors.

    DOI: 10.1038/s41467-024-53262-w

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  • Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells 査読

    Zhong P.S., Nakata K., Oyama K., Higashijima N., Sagara A., Date S., Luo H.Z., Hayashi M., Kubo A., Wu C.Y., He S., Yamamoto T., Koikawa K., Iwamoto C., Abe T., Ikenaga N., Ohuchida K., Morisaki T., Oda Y., Kuba K., Nakamura M.

    Journal of Experimental and Clinical Cancer Research   43 ( 1 )   138   2024年12月   ISSN:0392-9078

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    記述言語:英語   出版者・発行元:Journal of Experimental and Clinical Cancer Research  

    Background: Although immune checkpoint blockade (ICB) therapy has proven to be extremely effective at managing certain cancers, its efficacy in treating pancreatic ductal adenocarcinoma (PDAC) has been limited. Therefore, enhancing the effect of ICB could improve the prognosis of PDAC. In this study, we focused on the histamine receptor H1 (HRH1) and investigated its impact on ICB therapy for PDAC. Methods: We assessed HRH1 expression in pancreatic cancer cell (PCC) specimens from PDAC patients through public data analysis and immunohistochemical (IHC) staining. The impact of HRH1 in PCCs was evaluated using HRH1 antagonists and small hairpin RNA (shRNA). Techniques including Western blot, flow cytometry, quantitative reverse transcription polymerase chain reaction (RT-PCR), and microarray analyses were performed to identify the relationships between HRH1 and major histocompatibility complex class I (MHC-I) expression in cancer cells. We combined HRH1 antagonism or knockdown with anti-programmed death receptor 1 (αPD-1) therapy in orthotopic models, employing IHC, immunofluorescence, and hematoxylin and eosin staining for assessment. Results: HRH1 expression in cancer cells was negatively correlated with HLA-ABC expression, CD8+ T cells, and cytotoxic CD8+ T cells. Our findings indicate that HRH1 blockade upregulates MHC-I expression in PCCs via cholesterol biosynthesis signaling. In the orthotopic model, the combined inhibition of HRH1 and αPD-1 blockade enhanced cytotoxic CD8+ T cell penetration and efficacy, overcoming resistance to ICB therapy. Conclusions: HRH1 plays an immunosuppressive role in cancer cells. Consequently, HRH1 intervention may be a promising method to amplify the responsiveness of PDAC to immunotherapy.

    DOI: 10.1186/s13046-024-03060-5

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  • Dynamic glycolytic reprogramming effects on dendritic cells in pancreatic ductal adenocarcinoma 査読

    Zhang B., Ohuchida K., Tsutsumi C., Shimada Y., Mochida Y., Oyama K., Iwamoto C., Sheng N., Fei S., Shindo K., Ikenaga N., Nakata K., Oda Y., Nakamura M.

    Journal of Experimental and Clinical Cancer Research   43 ( 1 )   271   2024年12月   ISSN:0392-9078

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    記述言語:英語   出版者・発行元:Journal of Experimental and Clinical Cancer Research  

    Background: Pancreatic ductal adenocarcinoma tumors exhibit resistance to chemotherapy, targeted therapies, and even immunotherapy. Dendritic cells use glucose to support their effector functions and play a key role in anti-tumor immunity by promoting cytotoxic CD8+ T cell activity. However, the effects of glucose and lactate levels on dendritic cells in pancreatic ductal adenocarcinoma are unclear. In this study, we aimed to clarify how glucose and lactate can impact the dendritic cell antigen-presenting function and elucidate the relevant mechanisms. Methods: Glycolytic activity and immune cell infiltration in pancreatic ductal adenocarcinoma were evaluated using patient-derived organoids and resected specimens. Cell lines with increased or decreased glycolysis were established from KPC mice. Flow cytometry and single-cell RNA sequencing were used to evaluate the impacts on the tumor microenvironment. The effects of glucose and lactate on the bone marrow-derived dendritic cell antigen-presenting function were detected by flow cytometry. Results: The pancreatic ductal adenocarcinoma tumor microenvironment exhibited low glucose and high lactate concentrations from varying levels of glycolytic activity in cancer cells. In mouse transplantation models, tumors with increased glycolysis showed enhanced myeloid-derived suppressor cell infiltration and reduced dendritic cell and CD8+ T cell infiltration, whereas tumors with decreased glycolysis displayed the opposite trends. In three-dimensional co-culture, increased glycolysis in cancer cells suppressed the antigen-presenting function of bone marrow-derived dendritic cells. In addition, low-glucose and high-lactate media inhibited the antigen-presenting and mitochondrial functions of bone marrow-derived dendritic cells. Conclusions: Our study demonstrates the impact of dynamic glycolytic reprogramming on the composition of immune cells in the tumor microenvironment of pancreatic ductal adenocarcinoma, especially on the antigen-presenting function of dendritic cells.

    DOI: 10.1186/s13046-024-03192-8

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  • PRAME expression in fibrosarcomatous dermatofibrosarcoma protuberans 査読

    Ichiki T., Ito T., Shiraishi S., Nakashima Y., Nakahara T., Oda Y.

    Scientific Reports   14 ( 1 )   22973   2024年12月

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    記述言語:英語   出版者・発行元:Scientific Reports  

    PRAME (PReferentially expressed Antigen in MElanoma) was first identified as a malignant melanoma-specific antigen. Recently, a few cases of fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) were shown to have positivity for PRAME, while conventional dermatofibrosarcoma protuberans (C-DFSP) was negative. Because PRAME may be of diagnostic utility in FS-DFSP and is raising expectations as a new immunotherapy target, we examined the positivity of PRAME in FS-DFSP. Twenty-one cases of FS-DFSP and age/sex/location-matched cases of C-DFSP as a control group were examined by immunohistochemistry for CD34 and PRAME. The results were then evaluated by H-score, which was objectively and semi-quantitatively calculated using the open-source bioimaging analysis software QuPath. The results revealed that the PRAME H-score in FS-DFSP was significantly higher than that in C-DFSP (p = 0.0137). As for CD34, the H-score in FS-DFSP was significantly lower than that in C-DFSP (p < 0.001). Using these two immunohistochemical analyses in combination, the sensitivity and specificity for the diagnosis of FS-DFSP were 86% and 90%, respectively. Double staining of CD34 and PRAME revealed that PRAME-positive and CD34-positive areas did not overlap. This is the largest study to examine PRAME expression in FS-DFSP, and it confirmed the usefulness of PRAME in diagnosing this condition.

    DOI: 10.1038/s41598-024-74556-5

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  • The clinical significance of signal regulatory protein alpha expression in the immune environment of gastric cancer. 査読

    Tanaka Y, Hu Q, Kawazoe T, Tajiri H, Nakanishi R, Zaitsu Y, Nakashima Y, Ota M, Oki E, Oda Y, Yoshizumi T

    International journal of clinical oncology   2024年11月   ISSN:1341-9625

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    記述言語:英語  

    DOI: 10.1007/s10147-024-02666-1

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  • Study protocol: randomized phase III trial of neo-adjuvant and adjuvant chemotherapy vs. immediate surgery and adjuvant chemotherapy for localized soft tissue sarcoma: Japan Clinical Oncology Group study JCOG2102 (NACLESS). 査読

    Funauchi Y, Tsukushi S, Hiraga H, Sakamoto A, Kunisada T, Nagano A, Hiraoka K, Kikuta K, Yonemoto T, Ae K, Kawai A, Endo M, Sano Y, Machida R, Sekita T, Fukuda H, Oda Y, Ozaki T, Tanaka K, JCOG Bone Soft Tissue Tumor Study Group

    Japanese journal of clinical oncology   2024年11月   ISSN:0368-2811

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    記述言語:英語  

    DOI: 10.1093/jjco/hyae160

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  • CD155 Expression in Early-Stage Lung Adenocarcinoma

    Matsudo K., Takada K., Kinoshita F., Hashinokuchi A., Nagano T., Akamine T., Kohno M., Takenaka T., Shimokawa M., Oda Y., Yoshizumi T.

    Annals of Thoracic Surgery   2024年11月   ISSN:00034975

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    記述言語:英語   出版者・発行元:Annals of Thoracic Surgery  

    Background: Cluster of differentiation (CD) 155 is a transmembrane protein that belongs to the nectin-like molecule family, which is widely overexpressed in several types of cancer. However, the clinical significance of CD155 in pathologic stage I lung adenocarcinoma remains poorly understood. Methods: We analyzed 320 patients diagnosed with pathologic stage I lung adenocarcinoma who underwent surgical treatment at Kyushu University Hospital between 2006 and 2015. The number of tumor cells expressing CD155 was assessed by immunohistochemistry, and patients were categorized into high and low CD155 expression groups. We compared the clinical and pathologic characteristics and clinical outcomes between these groups. Results: Mutation status of the epidermal growth factor receptor gene (EGFR) was determined in 237 patients. A total of 106 patients (33.1%) had EGFR wild-type, and 131 patients (40.9%) had EGFR mutant-type. CD155 expression was classified as high in 77 patients (24.1%) and as low in 243 (75.9%) as low. Multivariate analysis identified pleural invasion and EGFR wild-type as independent predictors of high CD155 expression. The Kaplan-Meier plot demonstrated significantly poorer recurrence-free survival and overall survival in the high CD155 group compared with the low CD155 group. Multivariate analysis showed high CD155 expression was an independent poor prognostic factor for recurrence-free and overall survival. Subgroup analyses revealed that a prognostic difference related to CD155 expression was observed only in patients with EGFR wild-type but not in those with EGFR mutant-type. Conclusions: Our findings suggest that high expression of CD155 is associated with EGFR wild-type and could serve as a valuable prognostic marker in pathologic stage I lung adenocarcinoma, particularly in cases without EGFR mutation.

    DOI: 10.1016/j.athoracsur.2024.05.042

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  • Reappraisal of bone and soft tissue cytopathology classification using the modified Milan system

    Naka M., Yamamoto H., Kohashi K., Iwasaki T., Mori T., Nogami M., Ookubo F., Higuchi K., Motoi T., Oda Y.

    Cancer Cytopathology   2024年11月   ISSN:1934662X

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    記述言語:英語   出版者・発行元:Cancer Cytopathology  

    Background: A standardized reporting system for bone and soft tissue tumor cytopathology has not yet been established. The objective of this study was to explore the potential utility of a classification modified from the Milan System for Salivary Gland Cytopathology and compared it with the upcoming World Health Organization (WHO) system for fine-needle aspiration of soft tissue lesions. Methods: The authors reviewed 285 cytology cases of bone/joint (n = 173) and soft tissue (n = 112) lesions, scoring each within diagnostic categories. The results were compared with histologic diagnoses and the risk of malignancy (ROM) for each category, and diagnostic reliability was analyzed. Results: All 285 cases were successfully classified into one of the following categories: nondiagnostic (6.3%), non-neoplastic (11.9%), atypia of uncertain significance (11.9%), benign neoplasm (5.6%), bone and soft tissue neoplasm of uncertain malignant potential (25.3%), suspicious for malignancy (1.4%), and malignant (37.5%). The ROM was 44.4% (eight of /18 cases) in nondiagnostic, 0% (zero of 34 cases) in non-neoplastic, 32.4% (11 of 34 cases) in atypia of uncertain significance, 0% (zero of 16 cases) in benign neoplasm, 16.7% (12 of 72 cases) in bone and soft tissue neoplasm of uncertain malignant potential, 75.0% (three of four cases) in suspicious for malignancy, and 100% (107 of 107 cases) in malignant categories. Using the WHO system, the proportion and ROM of the benign category (non-neoplastic and benign neoplasm) was 17.5% and 0%, respectively. Among benign and malignant lesions, the diagnostic accuracy, sensitivity, and specificity for detecting malignancy were 99.4%, 100%, and 98.0%, respectively. Conclusions: The modified Milan system as well as the WHO system may be a useful cytopathologic classification tool for both bone and soft tissue lesions.

    DOI: 10.1002/cncy.22888

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  • The Association of Transferrin Receptor with Prognosis and Biologic Role in Intrahepatic Cholangiocarcinoma

    Toshida K., Itoh S., Iseda N., Izumi T., Bekki Y., Yoshiya S., Toshima T., Iwasaki T., Oda Y., Yoshizumi T.

    Annals of Surgical Oncology   2024年11月   ISSN:10689265

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    記述言語:英語   出版者・発行元:Annals of Surgical Oncology  

    Background: Ferroptosis is a cell death caused by iron-dependent accumulation of lipid peroxidation. Transferrin receptor (TFR) is a ferroptosis-related protein responsible for iron transport. The detailed biologic role of TFR in intrahepatic cholangiocarcinoma (ICC) is not fully elucidated. Methods: The study enrolled 92 ICC patients who had undergone hepatic resection. Immunohistochemistry (IHC) assays were performed for TFR protein expression. The regulation of malignant activity and the effect on sensitivity to the ferroptosis-inducer artesunate by TFR were investigated in vitro. Results: Using IHC staining, 23 patients were categorized as TFR-positive. The TFR-positive group had a significantly larger tumor size and more microscopic vascular invasion. In the multivariate analysis, TFR positivity was an independent poor prognostic factor. In vitro TFR-knockdown (KD) significantly decreased the intracellular iron levels and the cell proliferation, migration, and invasion rates. Artesunate treatment significantly decreased cell viability, whereas cisplatin promoted ferroptosis. When iron transport into cells was inhibited by TFR-KD, ferroptosis was significantly suppressed. Expression of PD-L1 was induced by cisplatin, with a further increase observed when artesunate and cisplatin were used in combination. Conclusions: Transferrin receptor is a poor prognostic factor for ICC and contributes to sensitivity to ferroptosis.

    DOI: 10.1245/s10434-024-16065-3

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  • Volume of hepatoid component and intratumor M2 macrophages predict prognosis in patients with hepatoid adenocarcinoma of the stomach 査読

    Taniguchi Y., Kiyozawa D., Kohashi K., Kawatoko S., Yamamoto T., Torisu T., Yoshizumi T., Nakamura M., Kitazono T., Oda Y.

    Gastric Cancer   2024年11月   ISSN:14363291

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    記述言語:英語   出版者・発行元:Gastric Cancer  

    Background: Hepatoid adenocarcinoma of the stomach (HAS), a subtype of gastric cancer (GC), includes multiple tumor components, such as enteroblastic and tubular adenocarcinoma components. However, which component mostly contributes to the aggressive behavior of HAS remains unclear. Moreover, the role of tumor-associated macrophages (TAMs) has not been explored in HAS. This study evaluated the clinical significance of the proportion of the hepatoid component within the tumor, CD163 + macrophages, and macrophage colony-stimulating factor-1 (CSF-1) in HAS. Methods: In total, 56 cases of primary HAS were analyzed. In each case, hepatoid (HC), enteroblastic (EC), and tubular (TC) components were identified, and the ratio of HC to the entire tumor (hepatoid component ratio, HCR) was assessed to examine the correlation between HCR and clinicopathological features. Immunohistochemical staining for CD163 and CSF-1 was performed, and differences in immunohistochemical results among the three tumor components were analyzed. In each tumor component, the prognostic impact of CD163 and CSF-1 was examined. Results: A high HCR was associated with worse overall survival (OS). CD163 + TAMs and CSF-1 immunoreactivity score in HC were significantly higher than those in the other components. High infiltration of CD163 + TAMs and a high CSF-1 immunoreactivity score in HC were associated with an aggressive course and worse OS. Multivariate analysis revealed the proportion of HC in HAS as an independent prognostic factor (HR = 3.176, p = 0.006). Conclusions: The HCR and CD163 + TAMs may be useful prognostic predictors, and TAMs may be novel therapeutic targets of HAS.

    DOI: 10.1007/s10120-024-01562-x

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  • The combination of p16 and Rb expression pattern is helpful to predict high-risk HPV infection and the primary site in lymph node metastases of squamous cell carcinoma. 査読

    Kuga R, Yamamoto H, Narutomi F, Suzuki M, Jiromaru R, Hongo T, Hachisuga K, Yasutake N, Kato K, Nakagawa T, Oda Y

    Pathology, research and practice   263   155642   2024年11月   ISSN:0344-0338

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    記述言語:英語  

    DOI: 10.1016/j.prp.2024.155642

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  • Clinicopathological Review of Head and Neck Squamous Cell Carcinomas After Neoadjuvant Chemotherapy 査読

    Kuga R., Hashimoto K., Yamamoto H., Taniguchi M., Manako T., Sato M., Kogo R., Matsuo M., Oda Y., Nakagawa T.

    Anticancer Research   44 ( 10 )   4593 - 4603   2024年10月   ISSN:02507005

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    記述言語:英語   出版者・発行元:Anticancer Research  

    Background/Aim: The benefit of neoadjuvant chemotherapy (NAC) in the treatment of head and neck squamous cell carcinoma (HNSCC) remains unclear. Patients and Methods: We retrospectively collected 30 patients with HNSCC who had undergone radical resection after NAC. We pathologically evaluated the therapeutic response to NAC, and classified the residual tumor patterns. In addition, we compared the maximum horizontal diameter on pathology with imaging. Results: The residual patterns were categorized as follows: 10 cases of shrunken type, 11 cases of mixed type, and seven cases of fragmented type. The majority of underestimation cases – those cases in which the maximum horizontal diameter measured on post-NAC imaging was less than the pathological size after resection – were multifocal residual lesions, with a tendency for more frequent “positive” or “close” surgical margins. Conclusion: The strategy of performing NAC to reduce resection volume is not appropriate, and resection margins should be based on the assessment before NAC.

    DOI: 10.21873/anticanres.17289

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  • TROP2 Expression and Therapeutic Implications in Cutaneous Squamous Cell Carcinoma: Insights From Immunohistochemical and Functional Analysis 査読

    Tanegashima K., Tanaka Y., Ito T., Oda Y., Nakahara T.

    Experimental Dermatology   33 ( 10 )   e15196   2024年10月   ISSN:09066705

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    記述言語:英語   出版者・発行元:Experimental Dermatology  

    Cutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer, but treatments for advanced cases have limited efficacy. Trophoblast cell-surface antigen 2 (TROP2) is a cell-surface protein that is widely expressed in various tumours, where it exerts significant influence over critical processes such as tumour cell growth, apoptosis, migration, invasion and metastasis. Sacituzumab govitecan, an antibody-drug conjugate (ADC) targeting TROP2, is emerging as a promising strategy for anticancer therapy. In this study, we investigated TROP2 expression in cSCC tissues from 51 patients and evaluated its function in the A431 human SCC cell line. Immunohistochemical analysis revealed TROP2 expression on the plasma membrane of cSCC tissues and A431 cells. A431 cells showed sensitivity to sacituzumab govitecan with a significant concentration-dependent decrease in viable cell number. In addition, Knockdown of TROP2 resulted in decreased expression of cyclin D1 and BCL-2, along with reduced cell viability. Knockdown of TROP2 also resulted in decreased expression of vimentin, along with reduced migratory capacity. These findings suggest that TROP2 plays a crucial role in cSCC cell proliferation and migration, and highlight the potential of sacituzumab govitecan as a promising therapeutic option for cSCC.

    DOI: 10.1111/exd.15196

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  • Translocation in bone and soft tissue sarcomas: a comprehensive epidemiological investigation.

    9 ( 10 )   103726   2024年9月

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    記述言語:英語  

    DOI: 10.1016/j.esmoop.2024.103726

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  • Combined Autophagy Inhibition and Dendritic Cell Recruitment Induces Antitumor Immunity and Enhances Immune Checkpoint Blockade Sensitivity in Pancreatic Cancer.

    Oyama K, Nakata K, Tsutsumi C, Hayashi M, Zhang B, Mochida Y, Shinkawa T, Hirotaka K, Zhong P, Date S, Luo H, Kubo A, Higashijima N, Yamada Y, Abe T, Ideno N, Koikawa K, Iwamoto C, Ikenaga N, Ohuchida K, Onishi H, Morisaki T, Kuba K, Oda Y, Nakamura M

    Cancer research   2024年9月   ISSN:0008-5472

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    記述言語:英語  

    DOI: 10.1158/0008-5472.CAN-24-0830

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  • TAK1 Promotes an Immunosuppressive Tumor Microenvironment through Cancer-Associated Fibroblast Phenotypic Conversion in Pancreatic Ductal Adenocarcinoma.

    Sheng N, Shindo K, Ohuchida K, Shinkawa T, Zhang B, Feng H, Yamamoto T, Moriyama T, Ikenaga N, Nakata K, Oda Y, Nakamura M

    Clinical cancer research : an official journal of the American Association for Cancer Research   2024年9月   ISSN:1078-0432

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    記述言語:英語  

    DOI: 10.1158/1078-0432.CCR-24-1004

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  • Clinical Significance of SIRPα Expression on Tumor-Associated Macrophages in Patients with Lung Squamous Cell Carcinoma

    Nagano T., Takada K., Narutomi F., Kinoshita F., Akamine T., Kohno M., Shimokawa M., Takenaka T., Oda Y., Yoshizumi T.

    Annals of Surgical Oncology   31 ( 9 )   6309 - 6319   2024年9月   ISSN:10689265

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    記述言語:英語   出版者・発行元:Annals of Surgical Oncology  

    Background: Signal-regulatory protein alpha (SIRPα) is an immune checkpoint molecule expressed on macrophages that functions to inhibit phagocytosis by binding to CD47 expressed on tumor cells. SIRPα has attracted increasing attention as a novel target for cancer immunotherapy; however, the expression and immune function of SIRPα in lung squamous cell carcinoma (LUSC) remain unclear. Therefore, this study aimed to identify the clinical importance of SIRPα expression in LUSC and to explore the factors that elevate SIRPα expression. Patients and Methods: Primary LUSC specimens surgically resected from 172 patients underwent immunohistochemical evaluation of the association of SIRPα expression on tumor-associated macrophages with clinicopathological features and clinical outcomes. Furthermore, we analyzed the association of SIRPα expression with tumor-infiltrating lymphocytes and the expression of programmed cell death ligand 1 (PD-L1). In vitro, monocytes were treated with cytokines, and SIRPα protein expression was assessed by flow cytometry. Results: There were no differences in SIRPα expression and clinicopathological factors. High SIRPα expression was significantly associated with PD-L1-positive expression, and high CD8, PD-1, and CD163 expression. The high SIRPα expression group showed significantly shorter recurrence-free survival (RFS) and overall survival (OS). On multivariate analysis, high SIRPα expression was an independent poor prognostic factor for RFS and OS. The expression of SIRPα protein in monocytes was upregulated by treatment with IFNγ. Conclusion: Our analysis revealed that high SIRPα expression significantly predicts poor prognosis in patients with surgically resected LUSC.

    DOI: 10.1245/s10434-024-15649-3

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  • Prognostic implications of the immunohistochemical expression of perilipin 1 and adipophilin in high-grade liposarcoma 査読

    Kawaguchi, K; Kohashi, K; Mori, T; Yamamoto, H; Iwasaki, T; Kinoshita, I; Susuki, Y; Furukawa, H; Endo, M; Matsumoto, Y; Nakashima, Y; Oda, Y

    77 ( 10 )   676 - 682   2024年9月   ISSN:0021-9746 eISSN:1472-4146

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  • Association between Vascular Calcification and Intraplaque Hemorrhage in Coronary Atherosclerosis from Autopsy: The Hisayama Study. 査読 国際誌

    Nakano T, Kitamura H, Hata J, Maki K, Oda Y, Kitazono T, Ninomiya T.

    J Atheroscler Thromb.    31 ( 8 )   1225 - 1237   2024年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.5551/jat.64394.

  • Expression of Forkhead Box M1 and Anticancer Effects of FOXM1 Inhibition in Epithelioid Sarcoma

    Shibui Y., Kohashi K., Hino Y., Tamaki A., Kinoshita I., Yamamoto H., Nakashima Y., Tajiri T., Oda Y.

    Laboratory Investigation   104 ( 8 )   102093   2024年8月   ISSN:00236837

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    記述言語:英語   出版者・発行元:Laboratory Investigation  

    Epithelioid sarcoma (ES) is a rare aggressive sarcoma that, unlike most soft-tissue sarcomas, shows a tendency toward local recurrence and lymph node metastasis. Novel antitumor agents are needed for ES patients. Forkhead box transcription factor 1 (FOXM1) is a member of the Forkhead transcription factor family and is associated with multiple oncogenic functions; FOXM1 is known to be overexpressed and correlated with pathogenesis in various malignancies. In this study, we immunohistochemically analyzed FOXM1 expression levels and their clinical, clinicopathologic, and prognostic significance in 38 ES specimens. In addition, to investigate potential correlations between FOXM1 downregulation and oncologic characteristics, we treated ES cell lines with thiostrepton, a naturally occurring antibiotic that inhibits both small interfering RNA (siRNA) and FOXM1. In the analyses using ES samples, all 38 specimens were diagnosed as positive for FOXM1 by immunohistochemistry. We separated specimens into high (n = 19) and low (n = 19) FOXM1–protein expression groups by staining index score, and into large (n = 12), small (n = 25), and unknown (n = 1) tumor-size groups using a cutoff of 5 cm maximum diameter. Although there were significantly more samples with high FOXM1 expression in the large tumor group (P = .013), there were no significant differences with respect to age (P = 1.00), gender (P = .51), primary site of origin (P = .74), histologic subtypes (P = 1.00), depth (P = .74), or survival rate (P = .288) between the high and low FOXM1–protein expression groups. In the in vitro experiments using ES cell lines, FOXM1 siRNA and thiostrepton successfully downregulated FOXM1 mRNA and protein expression. Furthermore, downregulation of FOXM1 inhibited cell proliferation, drug resistance against chemotherapeutic agents, migration, and invasion and caused cell cycle arrest in the ES cell lines. Finally, cDNA microarray analysis data showed that FOXM1 regulated cIAP2, which is one of the apoptosis inhibitors activated by the TNFα-mediated NF-κB pathway. In conclusion, the FOXM1 gene may be a promising therapeutic target for ES.

    DOI: 10.1016/j.labinv.2024.102093

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  • Papillary renal neoplasm with reverse polarity has low frequency of alterations in chromosomes 7, 17, and Y

    Kiyozawa D., Iwasaki T., Takamatsu D., Kohashi K., Miyamoto T., Fukuchi G., Eto M., Yamashita M., Oda Y.

    Virchows Archiv   485 ( 2 )   299 - 306   2024年8月   ISSN:09456317

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    記述言語:英語   出版者・発行元:Virchows Archiv  

    In papillary renal neoplasm with reverse polarity (PRNRP), the status of chromosomal copy number alterations, especially chromosomes 7/17 gain and chromosome Y loss, has remained controversial. In the literatures, there is a discrepancy among the results of chromosomal alteration in PRNRP depending on the analytical methods. Here, we comprehensively analyzed the status of chromosomal abnormalities in PRNRP. Nineteen PRNRP cases were analyzed by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC), five of which were additionally subjected to array-based comparative genomic hybridization (aCGH) analysis. Fifteen cases of PRCC were used as controls. From the aCGH results, no genome copy number abnormalities were found in the five PRNRP cases. By FISH, numbers of nuclei with abnormal chromosomal signals in PRNRP (centromere 7 gain: 11–21% of nuclei, centromere 17 gain: 11% of nuclei, centromere Y loss: 14–31% of nuclei) were similar to those in non-neoplastic tubular cells (centromere 7 gain: 11–15% of nuclei, centromere 17 gain: 12–15% of nuclei, centromere Y loss: 13–45% of nuclei). c-MET immunohistochemical overexpression, a substitute marker for chromosome 7 trisomy, was observed in 0 of 19 PRNRP cases, consistent with the analyses by aCGH and NGS regarding chromosome 7 gain. Taken together, the frequency of chromosomal alterations in PRNRP is similar to that in non-neoplastic tubular cells, and lower than that in PRCC. Our data suggest that PRNRP has a different tumorigenesis and is a distinct entity from PRCC.

    DOI: 10.1007/s00428-024-03840-6

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  • Geriatric nutritional risk index as a predictor for surgical site infection in malignant musculoskeletal tumours of the trunk.

    Shiraishi S, Fujiwara T, Nabeshima A, Iida K, Endo M, Matsumoto Y, Oda Y, Nakashima Y

    Japanese journal of clinical oncology   2024年7月   ISSN:0368-2811

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    DOI: 10.1093/jjco/hyae095

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  • Effect of HLA Genotype on Anti-PD-1 Antibody Treatment for Advanced Renal Cell Carcinoma in the SNiP-RCC Study

    Tanegashima T., Shiota M., Fujiyama N., Narita S., Habuchi T., Fukuchi G., Takamatsu D., Oda Y., Miyake H., Takahashi M., Oya M., Tsuchiya N., Masumori N., Matsuyama H., Obara W., Shinohara N., Fujimoto K., Nozawa M., Ohba K., Ohyama C., Hashine K., Akamatsu S., Kamba T., Mita K., Gotoh M., Tatarano S., Fujisawa M., Tomita Y., Mukai S., Ito K., Tokunaga S., Eto M.

    Journal of Immunology   213 ( 1 )   23 - 28   2024年7月   ISSN:00221767

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    記述言語:英語   出版者・発行元:Journal of Immunology  

    Immune checkpoint blockade therapies are widely used for cancer treatment, including advanced renal cell carcinoma (RCC). This study aimed to investigate the impact of zygosity in HLA genes and individual HLA genotypes on the efficacy of an anti-PD-1 Ab, nivolumab, in treating advanced RCC. Patient enrollment was conducted across 23 institutions in Japan from August 19, 2019, to September 30, 2020, with follow-up concluding on March 31, 2021. HLA genotype imputation of HLA-A, B, and C, DQB1, and DRB1 loci was performed. Among 222 patients, the presence of at least one homozygosity of the HLA-II allele significantly improved the best objective response (hazard ratio, 0.34; 95% confidence interval, 0.21-0.96; p 5 0.042). The HLA evolutionary divergence (HED) of the HLA-A and HLA-B loci was higher than the HLA-C (p < 0.0001 and p < 0.0001, respectively), with high HED of the HLA-B locus correlating to clinical benefits in nivolumab treatment (hazard ratio, 0.44; 95% confidence interval, 0.21-0.90; p 5 0.024) and improving cancer-specific survival compared with the low group (p 5 0.0202). Additionally, high HED of the HLA-B locus was correlated with the number of infiltrated CD8+ cells in the tumor microenvironment (correlation coefficient, 0.4042). These findings indicate that the diversity of the HLA-B locus plays a significant role in the anti-tumor effect of nivolumab treatment in advanced RCC, potentially offering insights for improved risk stratification in nivolumab treatment and leading to better medical management of advanced RCC. The Journal of Immunology, 2024, 213: 23-28.

    DOI: 10.4049/jimmunol.2300308

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  • A novel objective pathologic criterion for isolated hypoganglionosis. 査読 国際誌

    Tamaki A, Kohashi K, Yoshimaru K, Hino Y, Hamada H, Kawakubo N, Taguchi T, Tajiri T, Oda Y.

    Am J Surg Pathol.   48 ( 7 )   803 - 812   2024年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Clinical and Prognostic Significance of Glutathione Peroxidase 2 in Lung Adenocarcinoma 査読

    Hashinokuchi A., Matsubara T., Ono Y., Shunichi S., Matsudo K., Nagano T., Kinoshita F., Akamine T., Kohno M., Takenaka T., Oda Y., Yoshizumi T.

    Annals of Surgical Oncology   31 ( 7 )   4822 - 4829   2024年7月   ISSN:10689265

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    記述言語:英語   出版者・発行元:Annals of Surgical Oncology  

    Background: Glutathione peroxidase 2 (GPX2) is an antioxidant enzyme with an important role in tumor progression in various cancers. However, the clinical significance of GPX2 in lung adenocarcinoma has not been clarified. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to analyze GPX2 mRNA expression. Then, we conducted immunohistochemistry (IHC) to assess GPX2 expression in specimens acquired from 351 patients with lung adenocarcinoma who underwent surgery at Kyushu University from 2003 to 2012. We investigated the association between GPX2 expression and clinicopathological characteristics and further analyzed the prognostic relevance. Results: qRT-PCR revealed that GPX2 mRNA expression was notably higher in tumor cells than in normal tissues. IHC revealed that high GPX2 expression (n = 175, 49.9%) was significantly correlated with male sex, smoking, advanced pathological stage, and the presence of pleural, lymphatic, and vascular invasion. Patients with high GPX2 expression exhibited significantly shorter recurrence-free survival (RFS) and overall survival. Multivariate analysis identified high GPX2 expression as an independent prognostic factor of RFS. Conclusions: GPX2 expression was significantly associated with pathological malignancy. It is conceivable that high GPX2 expression reflects tumor malignancy. Therefore, high GPX2 expression is a significant prognostic factor of poor prognosis for completely resected lung adenocarcinoma.

    DOI: 10.1245/s10434-024-15116-z

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  • Immunohistochemical p16 overexpression and Rb loss correlate with high-risk human papillomavirus infection in endocervical adenocarcinomas. 査読 国際誌

    Yasutake N, Yamamoto H, Kuga R, Jiromaru R, Hongo T, Katayama Y, Sonoda K, Yahata H, Kato K, Oda Y.

    Histopathology.   84 ( 7 )   1178 - 1191   2024年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/his.15169.

  • FOXM1 and CHD4 expression is associated with chemoresistance in hepatoblastoma.

    Hino Y, Kohashi K, Tamaki A, Kawakubo N, Hamada H, Fukuhara M, Shibui Y, Tajiri T, Oda Y.

    Pathol Res Pract.   258   155348   2024年6月

  • Microenvironmental changes in familial adenomatous polyposis during colorectal cancer carcinogenesis 査読

    Hisano K., Mizuuchi Y., Ohuchida K., Kawata J., Torata N., Zhang J., Katayama N., Tsutsumi C., Nakamura S., Okuda S., Otsubo Y., Tamura K., Nagayoshi K., Ikenaga N., Shindo K., Nakata K., Oda Y., Nakamura M.

    Cancer Letters   589   216822   2024年5月   ISSN:03043835

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    記述言語:英語   出版者・発行元:Cancer Letters  

    Familial adenomatous polyposis (FAP) is a heritable disease that increases the risk of colorectal cancer (CRC) development because of heterozygous mutations in APC. Little is known about the microenvironment of FAP. Here, single-cell RNA sequencing was performed on matched normal tissues, adenomas, and carcinomas from four patients with FAP. We analyzed the transcriptomes of 56,225 unsorted single cells, revealing the heterogeneity of each cell type, and compared gene expression among tissues. Then we compared the gene expression with that of sporadic CRC. Furthermore, we analyzed specimens of 26 FAP patients and 40 sporadic CRC patients by immunohistochemistry. Immunosuppressiveness of myeloid cells, fibroblasts, and regulatory T cells was upregulated even in the early stages of carcinogenesis. CD8+ T cells became exhausted only in carcinoma, although the cytotoxicity of CD8+ T cells was gradually increased according to the carcinogenic step. When compared with those in the sporadic CRC microenvironment, the composition and function of each cell type in the FAP-derived CRC microenvironment had differences. Our findings indicate that an immunosuppressive microenvironment is constructed from a precancerous stage in FAP.

    DOI: 10.1016/j.canlet.2024.216822

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  • Clinicopathological significance of microsatellite instability and immune escape mechanism in patients with gastric solid-type poorly differentiated adenocarcinoma. 査読 国際誌

    Umekita S, Kiyozawa D, Kohashi K, Kawatoko S, Sasaki T, Ihara E, Oki E, Nakamura M, Ogawa Y, Oda Y.

    Gastric Cancer.   27 ( 3 )   484 - 494   2024年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s10120-024-01474-w

  • Single-Cell and Spatial Transcriptomics Analysis of Human Adrenal Aging. 査読 国際誌

    Iwahashi N, Umakoshi H, Fujita M, Fukumoto T, Ogasawara T, Yokomoto-Umakoshi M, Kaneko H, Nakao H, Kawamura N, Uchida N, Matsuda Y, Sakamoto R, Seki M, Suzuki Y, Nakatani K, Izumi Y, Bamba T, Oda Y, Ogawa Y.

    Mol Metab.   84   101954   2024年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molmet.2024.101954

  • Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine. 査読 国際誌

    Imazu N, Torisu T, Yokote A, Umeno J, Kawasaki K, Fujioka S, Matsuno Y, Nagasue T, Kawatoko S, Moriyama T, Nitahata T, Uchida Y, Aihara S, Taniguchi Y, Oda Y, Kitazono T.

    J Gastroenterol.   59 ( 8 )   682 - 698   2024年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00535-024-02104-z

  • The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia. 査読 国際誌

    Ikeda H, Ihara E, Takeya K, Mukai K, Onimaru M, Ouchida K, Hata Y, Bai X, Tanaka Y, Sasaki T, Saito F, Eto M, Nakayama J, Oda Y, Nakamura M, Inoue H, Ogawa Y.

    J Gastroenterol.   59 ( 5 )   361 - 375   2024年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00535-024-02088-w

  • Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis. 査読 国際誌

    Hashimoto M, Kojima Y, Sakamoto T, Ozato Y, Nakano Y, Abe T, Hosoda K, Saito H, Higuchi S, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Hata T, Nagayama S, Kagawa K, Goto Y, Utou M, Gamachi A, Imamura K, Kuze Y, Zenkoh J, Suzuki A, Takahashi K, Niida A, Hirose H, Hayashi S, Koseki J, Fukuchi S, Murakami K, Yoshizumi T, Kadomatsu K, Tobo T, Oda Y, Uemura M, Eguchi H, Doki Y, Mori M, Oshima M, Shibata T, Suzuki Y, Shimamura T, Mimori K.

    EBioMedicine.   103   105102   2024年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ebiom.2024.105102

  • Immune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8+ T cell infiltration. 査読 国際誌

    Kanahori M, Shimada E, Matsumoto Y, Endo M, Fujiwara T, Nabeshima A, Hirose T, Kawaguchi K, Oyama R, Oda Y, Nakashima Y.

    Br J Cancer.   130 ( 7 )   1083 - 1095   2024年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41416-024-02576-z.

  • Association between hypothalamic Alzheimer's disease pathology and body mass index: The Hisayama study. 査読 国際誌

    Yagita K, Honda H, Ohara T, Koyama S, Noguchi H, Oda Y, Yamasaki R, Isobe N, Ninomiya T.

    (Online ahead of print.) Neuropathology.   2024年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/neup.12974.

  • Impact of ACSL4 on the prognosis of hepatocellular carcinoma: Association with cancer-associated fibroblasts and the tumour immune microenvironment. 査読 国際誌

    Toshida K, Itoh S, Iseda N, Tomiyama T, Yoshiya S, Toshima T, Liu YC, Iwasaki T, Okuzaki D, Taniguchi K, Oda Y, Mori M, Yoshizumi T.

    Liver Int.   44 ( 4 )   1011 - 1023   2024年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/liv.15839.

  • Patient-derived organoids of pancreatic ductal adenocarcinoma for subtype determination and clinical outcome prediction. 査読 国際誌

    Matsumoto K, Fujimori N, Ichihara K, Takeno A, Murakami M, Ohno A, Kakehashi S, Teramatsu K, Ueda K, Nakata K, Sugahara O, Yamamoto T, Matsumoto A, Nakayama KI, Oda Y, Nakamura M, Ogawa Y.

    J Gastroenterol.   59 ( 7 )   629 - 640   2024年4月   ISSN:09441174

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00535-024-02103-0

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  • Clinical features and oncological outcomes of bladder cancer microsatellite instability

    Nagakawa S., Shiota M., Takamatsu D., Tsukahara S., Mastumoto T., Blas L., Inokuchi J., Oda Y., Eto M.

    International Journal of Urology   31 ( 4 )   438 - 445   2024年4月   ISSN:09198172

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    記述言語:英語   出版者・発行元:International Journal of Urology  

    Objectives: Excellent anticancer effect for solid tumors with microsatellite instability (MSI)-high by anti-PD-1 antibody has been reported. In this study, we investigated the clinical impact of MSI status in bladder cancer. Methods: This study included 205 Japanese patients who underwent transurethral resection for bladder cancer between 2005 and 2021. The prevalence rates of microsatellite stable (MSS), MSI-low (MSI-L), and MSI-high (MSI-H) were determined using molecular testing. We examined the association of MSI status (MSS versus MSI-L/H) with clinicopathological characteristics and oncological outcomes. Results: MSI-L/H tumors were associated with higher T-category in non-muscle invasive bladder cancer (NMIBC). Additionally, MSI-L/H tumors were associated with a higher risk of intravesical recurrence in NMIBC patients treated with intravesical bacillus Calmette-Guérin (BCG) but not with non-BCG therapy. Conclusions: This study suggested that the MSI status might serve as a predictive marker for intravesical recurrence after BCG intravesical therapy in NMIBC and highlighted an unmet need for an alternative treatment in patients with MSI-L/H tumors.

    DOI: 10.1111/iju.15370

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  • Immature stroma and high infiltration of CD15+ cells are predictive markers of poor prognosis in different subsets of patients with pancreatic cancer. 査読 国際誌

    Yamada Y, Yamamoto T, Tsutsumi C, Matsumoto T, Noguchi S, Shimada Y, Nakata K, Ohuchida K, Nakamura M, Oda Y.

    Cancer Sci.   115 ( 3 )   1001 - 1013   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/cas.16060.

  • DDIT3-amplified or low-polysomic pleomorphic sarcomas without MDM2 amplification: Clinicopathological review and immunohistochemical profile of nine cases. 査読 国際誌

    Mori T, Iwasaki T, Sonoda H, Kawaguchi K, Tomonaga T, Furukawa H, Sato C, Shiraishi S, Taguchi K, Tamiya S, Yoneda R, Oshiro Y, Matsunobu T, Abe C, Kuboyama Y, Ueki N, Kohashi K, Yamamoto H, Nakashima Y, Oda Y.

    Hum Pathol.   145   56 - 62   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2024.02.007.

  • Steroids-producing nodules: a two-layered adrenocortical nodular structure as a precursor lesion of cortisol-producing adenoma. 査読 国際誌

    Fukumoto T, Umakoshi H, Iwahashi N, Ogasawara T, Yokomoto-Umakoshi M, Kaneko H, Fujita M, Uchida N, Nakao H, Kawamura N, Matsuda Y, Sakamoto R, Miyazawa T, Seki M, Eto M, Oda Y, Suzuki Y, Ogawa S, Ogawa Y.

    (Online ahead of print.) EBioMedicine.   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ebiom.2024.105087.

  • Gene amplification of chromatin remodeling factor SMARCC2 and low protein expression of ACTL6A are unfavorable factors in ovarian high‑grade serous carcinoma. 査読 国際誌

    Magarifuchi N, Iwasaki T, Katayama Y, Tomonaga T, Nakashima M, Narutomi F, Kato K, Oda Y.

    Oncol Lett.   27 ( 5 )   196   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Nuclear morphological atypia in biopsy accurately reflects the prognosis of myxoid liposarcoma. 査読 国際誌

    Kawaguchi K, Kohashi K, Iwasaki T, Mori T, Furukawa H, Sato C, Sonoda H, Shiraishi S, Endo M, Nakashima Y, Oda Y.

    (Online ahead of print.) Virchows Arch.   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00428-024-03796-7.

  • Tumor-infiltrating monocytic myeloid-derived suppressor cells contribute to the development of an immunosuppressive tumor microenvironment in gastric cancer. 査読 国際誌

    Tsutsumi C, Ohuchida K, Katayama N, Yamada Y, Nakamura S, Okuda S, Otsubo Y, Iwamoto C, Torata N, Horioka K, Shindo K, Mizuuchi Y, Ikenaga N, Nakata K, Nagai E, Morisaki T, Oda Y, Nakamura M.

    Gastric Cancer.   27 ( 2 )   248 - 262   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10120-023-01456-4.

  • MicroRNA-20a in extracellular vesicles derived from duodenal fluid is a possible biomarker for pancreatic ductal adenocarcinoma. 査読 国際誌

    Taniguchi T, Ideno N, Araki T, Miura S, Yamamoto M, Nakafusa T, Higashijima N, Yamamoto T, Tamura K, Nakamura S, Abe T, Ikenaga N, Nakata K, Ohuchida K, Oda Y, Ohtsuka T, Nakamura M.

    DEN Open.   4 ( 1 )   e333   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/deo2.333.

  • Comparison of diagnostic performance of radiologist- and AI-based assessments of T2-FLAIR mismatch sign and quantitative assessment using synthetic MRI in the differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, IDH-mutant and 1p/19q-codeleted. 査読 国際誌

    Kikuchi K, Togao O, Yamashita K, Momosaka D, Kikuchi Y, Kuga D, Yuhei S, Fujioka Y, Narutomi F, Obara M, Yoshimoto K, Ishigami K.

    Neuroradiology.   66 ( 3 )   333 - 341   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00234-024-03288-0.

  • FOXM1: a new therapeutic target of extramammary Paget disease. 査読 国際誌

    Ito T, Tanaka Y, Kaku‑Ito Y, Oda Y, Nakahara T.

    Sci Rep.   14 ( 1 )   4048   2024年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Prognostic evaluation of the Ki-67 labeling system in histological grading of non-small round cell sarcoma: a supplementary analysis of a randomized controlled trial, JCOG1306. 査読 国際誌

    Sugita S, Tanaka K, Oda Y, Nojima T, Konishi N, Machida R, Kita R, Fukuda H, Ozaki T, Hasegawa T.

    (Online ahead of print.) Jpn J Clin Oncol.   2024年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jjco/hyae020

  • Multiparametric assessment of microvascular invasion in hepatocellular carcinoma using gadoxetic acid-enhanced MRI. 査読 国際誌

    Fujita N, Ushijima Y, Ishimatsu K, Okamoto D, Wada N, Takao S, Murayama R, Itoyama M, Harada N, Maehara J, Oda Y, Ishigami K, Nishie A.

    Abdom Radiol (NY).   49 ( 5 )   1467 - 1478   2024年2月   ISSN:2366004X

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00261-023-04179-3

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  • Comparative analyses of tumour immune microenvironment between collecting duct carcinoma and fumarate hydratase-deficient renal cell carcinoma. 査読 国際誌

    Kiyozawa D, Kohashi K, Takamatsu D, Umekita S, Eto M, Kinjo M, Nishiyama K, Taguchi K, Oshiro Y, Kuboyama Y, Oda Y.

    J Clin Pathol.   77 ( 2 )   105 - 110   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/jcp-2022-208589.

  • Viable tumor cell density after neoadjuvant chemotherapy assessed using deep learning model reflects the prognosis of osteosarcoma. 査読 国際誌

    Kawaguchi K, Miyama K, Endo M, Bise R, Kohashi K, Hirose T, Nabeshima A, Fujiwara T, Matsumoto Y, Oda Y, Nakashima Y.

    NPJ Precis Oncol.   8 ( 1 )   16   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41698-024-00515-y.

  • Impact of TP53-induced glycolysis and apoptosis regulator on malignant activity and resistance to ferroptosis in intrahepatic cholangiocarcinoma. 査読 国際誌

    Toshida K, Itoh S, Iseda N, Izumi T, Yoshiya S, Toshima T, Ninomiya M, Iwasaki T, Oda Y, Yoshizumi T.

    Cancer Sci.   115 ( 1 )   170 - 183   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/cas.15981.

  • Results of the JRS-I LRA0401 and LRB0402 Japan Rhabdomyosarcoma Study Group trials for low-risk embryonal rhabdomyosarcoma

    Hosoi H., Miyachi M., Teramukai S., Sakabayashi S., Tsuchiya K., Kuwahara Y., Onodera R., Matsuyama K., Yokota I., Hojo H., Okita H., Hata J.I., Hamasaki M., Tsuneyoshi M., Oda Y., Nakazawa A., Kato M., Takimoto T., Horibe K., Hara J.I., Suita S., Hanada R., Masaki H., Nozaki M., Ikeda H., Kishimoto S., Kaneko M., Kawai A., Morikawa Y.

    International Journal of Clinical Oncology   2024年   ISSN:13419625

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    記述言語:英語   出版者・発行元:International Journal of Clinical Oncology  

    Background: Failure-free survival (FFS) rates of low-risk patients with rhabdomyosarcoma improved in Intergroup Rhabdomyosarcoma Study IV after the escalation of cyclophosphamide total dose to 26.4 g/m2. However, this dose may increase the risk of adverse events, including infertility, in some patients. The JRS-I LRA0401 and LRB0402 protocols aimed to reduce the cyclophosphamide dose to 9.6 g/m2 and 17.6 g/m2, respectively, without decreasing the FFS rates. Methods: Subgroup-A patients received eight cycles (24 weeks) of vincristine, actinomycin D, and 1.2 g/m2/cycle cyclophosphamide. Subgroup-B patients received eight cycles (24 weeks) of vincristine, actinomycin D, and 2.2 g/m2/cycle cyclophosphamide, followed by six cycles (24 weeks) of vincristine and actinomycin D. Group II/III patients in both subgroups received radiotherapy. Results: In subgroup A (n = 12), the 3-year FFS rate was 83% (95% confidence interval [CI], 48–96), and the 3-year overall survival (OS) rate was 100%. Only one isolated local recurrence was observed (8.3%). There were no unexpected grade-4 toxicities and no deaths. In subgroup B (n = 16), the 3-year FFS and OS rates were 88% (95% CI, 59–97) and 94% (95% CI, 63–99), respectively. There were no unexpected grade 4 toxicities and no deaths. Conclusions: Shorter duration therapy using vincristine, actinomycin D, and lower dose cyclophosphamide with or without radiotherapy for patients with low-risk subgroup A rhabdomyosarcoma (JRS-I LRA0401 protocol) and moderate reduction of cyclophosphamide dose for patients with low-risk subgroup B rhabdomyosarcoma (JRS-I LRB0402 protocol) did not compromise FFS.

    DOI: 10.1007/s10147-024-02608-x

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  • Tumor infiltration of inactive CD8 + T cells was associated with poor prognosis in Gastric Cancer

    Katayama N., Ohuchida K., Son K., Tsutsumi C., Mochida Y., Noguchi S., Iwamoto C., Torata N., Horioka K., Shindo K., Mizuuchi Y., Ikenaga N., Nakata K., Oda Y., Nakamura M.

    Gastric Cancer   2024年   ISSN:14363291

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    記述言語:英語   出版者・発行元:Gastric Cancer  

    Background: Gastric cancer (GC) shows limited response to immune checkpoint inhibitors due to its complex tumor immune microenvironment (TIME). This study explores the functions of various immune cells in the complex TIME in GC. Methods: We assessed CD8 + T-cell infiltration of GC tissues by immunohistochemistry, and performed single-cell RNA sequencing (scRNA-seq) of tumor and normal tissues from 34 patients with GC. Results: We categorized 157 GC patients into LOW, MID, and HIGH groups based on their CD8 + T-cell infiltration. Overall survival was notably lower for the HIGH and LOW groups compared with the MID group. Our scRNA-seq data analysis showed that CD8 + T-cell activity markers in the HIGH group were expressed at lower levels than in normal tissue, but the T-cell-attracting chemokine CCL5 was expressed at a higher level. Notably, CD8 + T-cells in the HIGH group displayed lower PD1 expression and higher CTLA4 expression. TCR repertoire analysis using only Epstein–Barr virus-negative cases showed that CD8 + T-cell receptor clonality was lower in the HIGH group than in the MID group. Furthermore, in the HIGH group, the antigen-presenting capacity of type 1 conventional dendritic cells was lower, the immunosuppressive capacity of myeloid-derived suppressor cells was higher, and the expression of CTLA4 in regulatory T-cells was higher. Conclusion: The present data suggest that the infiltration of inactive CD8 + T-cells with low clonality is induced by chemotaxis in the HIGH group, possibly leading to a poor prognosis for patients with GC.

    DOI: 10.1007/s10120-024-01577-4

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  • Loss of SMARCA4 induces sarcomatogenesis through epithelial–mesenchymal transition in ovarian carcinosarcoma

    Katayama Y., Iwasaki T., Yamamoto T., Shimada N., Nakashima M., Toya M., Narutomi F., Tomonaga T., Kato K., Oda Y.

    Cancer Science   2024年   ISSN:13479032

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    記述言語:英語   出版者・発行元:Cancer Science  

    Ovarian carcinosarcoma (OCS) is a rare and aggressive tumor, and the development of its sarcomatous component is believed to be due to epithelial–mesenchymal transition (EMT). The SWIch/sucrose nonfermentable chromatin remodeling factor (CRF) is closely related to EMT; however, the relationship between CRF and EMT in OCS remains unclear. In this study, we analyzed the protein expression of CRFs, including ARID1A and SMARCA4, and their downstream mRNA expression in 28 OCS cases, two fallopian tube CS cases, and one peritoneal CS case. ARID1A and SMARCA4 exhibited a histological type-specific loss of protein expression in 5 of 11 (45%) endometrioid cases and all 5 serous/homologous OCS cases, respectively. The mRNA analysis suggested that sarcomatogenesis is induced by the transforming growth factor-β and Hippo signaling pathways, both of which regulate YAP1. Immunostaining for YAP1 suggested YAP1-associated sarcomatogenesis in the CRF-retained group, whereas YAP1-unassociated sarcomatogenesis was suggested in the CRF-reduced group. High-grade serous carcinoma cell line experiments showed that the transcriptome of the SMARCA4-knockdown group showed lower expression of the epithelial gene CDH1 and higher expression of mesenchymal genes such as VIM, ZEB1, and SNAI1 than the control group. Moreover, cell adhesion disappeared and cell morphology changed to a spindle shape, indicating sarcomatogenesis. In conclusion, this study reveals a mechanism for sarcoma development in OCS and provides novel therapeutic possibilities.

    DOI: 10.1111/cas.16423

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  • Clinical significance of CD155 expression in surgically resected lung squamous cell carcinoma 査読

    Nagano T., Takada K., Hashinokuchi A., Matsudo K., Kinoshita F., Akamine T., Kohno M., Shimokawa M., Takenaka T., Oda Y., Yoshizumi T.

    International Journal of Clinical Oncology   2024年   ISSN:13419625

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    記述言語:英語   出版者・発行元:International Journal of Clinical Oncology  

    Background: Cluster of differentiation 155 (CD155) is expressed in many tumor types. CD155 is involved in the immune avoidance of tumor cells and contributes to tumor development and progression. Therefore, CD155 is a novel target for cancer immunotherapy. The clinical significance of CD155 expression in lung squamous cell carcinoma (LUSC) has not been fully elucidated. Materials and methods: We performed a retrospective analysis of 264 patients with surgically resected LUSC. Immunohistochemistry was used to evaluate CD155 expression. The association of CD155 expression with clinicopathological features and clinical outcomes was assessed. We also analyzed the relationship between CD155 expression and programmed cell death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes. Results: Among the 264 patients, 137 patients (51.9%) were classified in the high CD155 expression group. High CD155 expression was significantly associated with pleural invasion, vascular invasion, PD-L1 positivity, and high CD3, CD4, and CD8 expressions. In multivariate analysis, the presence of pleural invasion and PD-L1 positivity were independent predictors of high CD155 expression. Kaplan–Meier curve analysis showed that high CD155 expression was significantly associated with shorter disease-free survival and overall survival. In multivariate analysis, high CD155 expression was an independent poor prognostic factor for overall survival, but not for disease-free survival. Subgroup analyses revealed that the prognostic effect of CD155 expression was observed in the PD-L1 positive group but not the PD-L1 negative group. Conclusion: Our analysis revealed that high CD155 expression significantly predicted poor prognosis in patients with surgically resected LUSC, especially in patients with PD-L1-positive tumors.

    DOI: 10.1007/s10147-024-02640-x

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  • Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab 査読

    Matsumura Takashi, Tsuchihashi Kenji, Yamamoto Takeo, Jinnouchi Fumiaki, Kusano Wataru, Kusumoto Yota, Arimizu Kohei, Ohmura Hirofumi, Kuma Yuki, Moriyama Shohei, Yamaguchi Kyoko, Ito Mamoru, Isobe Taichi, Ariyama Hiroshi, Oda Yoshinao, Akashi Koichi, Baba Eishi

    Internal Medicine   advpub ( 0 )   2024年   ISSN:09182918 eISSN:13497235

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    記述言語:英語   出版者・発行元:The Japanese Society of Internal Medicine  

    <p>A 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood. The patient was diagnosed with other iatrogenic immunodeficiency-associated lymph proliferative disorders (OIIA-LPDs) related to EBV activation induced by pembrolizumab. Rituximab was administered, resulting in the improvement of the OIIA-LPD. The emergence of an OIIA-LPD merits close attention in patients receiving immune checkpoint inhibitors. </p>

    DOI: 10.2169/internalmedicine.3743-24

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    CiNii Research

  • Transferrin receptor is associated with sensitivity to ferroptosis inducers in hepatocellular carcinoma. 査読 国際誌

    Hiromatsu M, Toshida K, Itoh S, Harada N, Kohashi K, Oda Y, Yoshizumi T.

    Ann Surg Oncol.   30 ( 13 )   8675 - 8689   2023年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1245/s10434-023-14053-7.

  • Comparison of radiological and pathological tumor sizes in resected non-small cell lung cancer. 査読 国際誌

    Nagano T, Takamori S, Hashinokuchi A, Matsydo K, Kohno M, Miura N, Takenaka T, Kamitani T, Shimokawa M, Ishigami K, Oda Y, Yoshizumi T.

    Gen Thorac Cardiovasc Surg.   71 ( 12 )   708 - 714   2023年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s11748-023-01938-3.

  • Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

    Tamura T., Yamasoba D., Oda Y., Ito J., Kamasaki T., Nao N., Hashimoto R., Fujioka Y., Suzuki R., Wang L., Ito H., Kashima Y., Kimura I., Kishimoto M., Tsuda M., Sawa H., Yoshimatsu K., Yamamoto Y., Nagamoto T., Kanamune J., Suzuki Y., Ohba Y., Suzuki S., Kato M., Ferdous Z., Mouri H., Shishido K., Misawa N., Uriu K., Kosugi Y., Fujita S., Suganami M., Chiba M., Yoshimura R., Nakagawa S., Wu J., Takaori-Kondo A., Shirakawa K., Nagata K., Kazuma Y., Nomura R., Horisawa Y., Tashiro Y., Kawai Y., Hashiguchi T., Suzuki T., Kimura K., Sasaki J., Nakajima Y., Sakamoto A., Yasuhara N., Irie T., Kawabata R., Ikeda T., Nasser H., Shimizu R., Begum M., Takahashi O., Ichihara K., Ueno T., Motozono C., Toyoda M., Saito A., Tanaka Y.L., Butlertanaka E.P., Shofa M., Tabata K., Yokota I., Matsuno K., Takayama K., Tanaka S., Sato K., Fukuhara T.

    Communications Biology   6 ( 1 )   2023年12月

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    出版者・発行元:Communications Biology  

    The unremitting emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates ongoing control measures. Given its rapid spread, the new Omicron subvariant BA.5 requires urgent characterization. Here, we comprehensively analyzed BA.5 with the other Omicron variants BA.1, BA.2, and ancestral B.1.1. Although in vitro growth kinetics of BA.5 was comparable among the Omicron subvariants, BA.5 was much more fusogenic than BA.1 and BA.2. Airway-on-a-chip analysis showed that, among Omicron subvariants, BA.5 had enhanced ability to disrupt the respiratory epithelial and endothelial barriers. Furthermore, in our hamster model, in vivo pathogenicity of BA.5 was slightly higher than that of the other Omicron variants and less than that of ancestral B.1.1. Notably, BA.5 gains efficient virus spread compared with BA.1 and BA.2, leading to prompt immune responses. Our findings suggest that BA.5 has low pathogenicity compared with the ancestral strain but enhanced virus spread /inflammation compared with earlier Omicron subvariants.

    DOI: 10.1038/s42003-023-05081-w

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  • Successful Treatment against Mediastinal Methicillin-resistant <i>Staphylococcus aureus</i> Infection after an Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Procedure

    Jo Akihiro, Ikegame Satoshi, Kiyozawa Daisuke, Yoneshima Yasuto, Oda Yoshinao, Okamoto Isamu

    Respiratory Endoscopy   1 ( 2 )   78 - 82   2023年11月   eISSN:27583813

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    記述言語:英語   出版者・発行元:The Japan Society for Respiratory Endoscopy  

    <p>The case involves a 57-year-old man with a history of laryngeal and lung cancers. He underwent a laryngectomy and right upper lobectomy and developed tracheal methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) colonization. He also underwent endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to diagnose right mediastinal lymph node adenopathy. His recovery was complicated by a mediastinal infection caused by MRSA five days post-procedure. Combining triple antibiotics comprising MEPM, DAP, and VCM for three weeks gradually improved the mediastinal infection. To our knowledge, this is the first report of mediastinal infection caused by MRSA after EBUS-TBNA. Our successful treatment of EBUS-TBNA-related infectious complications gives us information regarding rare complications management caused by EBUS-TBNA.</p>

    DOI: 10.58585/respend.2023-0007

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  • Preferential B cell differentiation by combined immune checkpoint blockade for renal cell carcinoma is associated with clinical response and autoimmune reactions. 査読 国際誌

    Uehara K, Tanoue K, Yamaguchi K, Ohmura H, Ito M, Matsushita Y, Tsuchihashi K, Tamura S, Shimokawa H, Isobe T, Shibata Y, Ariyama H, Tanaka R, Kusaba H, Yamamoto H, Oda Y, Akashi K, Baba E.

    Cancer Immunol Immunother.   72 ( 11 )   3543 - 3558   2023年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00262-023-03505-4.

  • Homologous recombination repair gene alterations are associated with tumor mutational burden and survival of immunotherapy. 査読 国際誌

    Ito M, Kubo M, Kawaji H, Otsubo Y, Kurata K, Abutani H, Suyama M, Oda Y, Yoshizumi T, Nakamura M, Baba E.

    Cancers (Basel).   15 ( 23 )   5608   2023年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.3390/cancers15235608.

  • Granzyme B (GZMB)-positive tumor-infiltrating lymphocytes in lung adenocarcinoma: significance as a prognostic factor and association with immunosuppressive proteins. 査読 国際誌

    Kinoshita F, Takada K, Wakasu S, Saito S, Hashinokuchi A, Matsudo K, Nagano T, Akamine T, Kohno M, Takenaka T, Shimokawa M, Oda Y, Yoshizumi T.

    Ann Surg Oncol.   30 ( 12 )   7579 - 7589   2023年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1245/s10434-023-14085-z.

  • MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma. 査読 国際誌

    Nakanishi T, Yoneshima Y, Okamura K, Yanagihara T, Hashisako M, Iwasaki T, Haratake N, Mizusaki S, Ota K, Iwama E, Takenaka T, Tanaka K, Yoshizumi T, Oda Y, Okamoto I.

    Cancer Sci.   114 ( 10 )   4101 - 4113   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/cas.15921.

  • Survival outcomes including salvage therapy of adult head and neck para-meningeal rhabdomyosarcoma: a multicenter retrospective study from Japan. 査読 国際誌

    BMC Cancer.   23 ( 1 )   1046   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1186/s12885-023-11528-4.

  • Tertiary lymphoid structures correlate with enhancement of antitumor immunity in esophageal squamous cell carcinoma. 査読 国際誌

    Nakamura S, Ohuchida K, Hayashi M, Katayama N, Tsutsumi C, Yamada Y, Hisano K, Okuda S, Ohtsubo Y, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Nakata K, Moriyama T, Morisaki T, Oda Y, Nakamura M.

    Br J Cancer.   129 ( 8 )   1314 - 1326   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41416-023-02396-7

  • Nonmass-forming type anorectal cancer with pagetoid spread: A report of two cases

    Yamamoto, M; Mizuuchi, Y; Tamura, K; Sada, M; Nagayoshi, K; Nakata, K; Ohuchida, K; Oda, Y; Nakamura, M

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   16 ( 4 )   747 - 752   2023年10月   ISSN:1758-5902 eISSN:1758-5910

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    記述言語:英語   出版者・発行元:Asian Journal of Endoscopic Surgery  

    Pagetoid spread (PS) of anorectal cancer is relatively rare and associated with poor prognosis. While a primary tumorous lesion is usually obvious in most PS cases, we experienced two cases of nonmass-forming type anorectal cancer with PS. It remains challenging to decide strategies. In both cases, histological findings of a perianal skin biopsy showed proliferation of atypical cells that were positive for cytokeratin (CK) 7, CK20, and caudal type homeobox 2 and negative for Gross cystic disease fluid protein 15, suggesting PS. Abdominoperineal resection (APR) with extensive anal skin resection was performed in both patients. The pathological diagnosis in each was nonmass-forming type anorectal cancer with PS. Neither has experienced recurrence in postoperative courses. Even nonmass-forming type anorectal cancer with PS could have high malignant potentials. APR with lymph nodes dissection and wide skin excision and regular surveillance might be necessary.

    DOI: 10.1111/ases.13217

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  • Lynch症候群による遠位十二指腸腺癌に対してペムブロリズマブによる免疫療法後に病理学的完全奏効を達成した症例 症例報告(A pathological complete response after immunotherapy with pembrolizumab for distal duodenal adenocarcinoma caused by Lynch syndrome: a case report)

    Ikeda Shinichiro, Hu Qingjiang, Natsugoe Keita, Harima Tomoya, Tanaka Yasushi, Kinoshita Izumi, Nonaka Kentaro, Nambara Sho, Nakanishi Ryota, Nakanoko Tomonori, Ota Mitsuhiko, Kimura Yasue, Oki Eiji, Oda Yoshinao, Yoshizumi Tomoharu

    International Cancer Conference Journal   12 ( 4 )   279 - 284   2023年10月

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    記述言語:英語   出版者・発行元:シュプリンガー・ジャパン(株)  

    症例は55歳女性。腹痛を主訴に受診し、上部消化管内視鏡検査で十二指腸第3部にBorrmann 2型腫瘍が認められ、生検により高頻度マイクロサテライト不安定性(MSI-H)と高分化型から中分化型の腺癌が明らかになった。上部消化管造影とCTでも十二指腸に腫瘍が認められ、ステージIV十二指腸腺癌と診断した。腫瘍は左腎静脈に近接しており、小腸の腸間膜リンパ節転移も認められたため、ペムブロリズマブによる術前治療を開始した。2コース終了後に十二指腸狭窄のため緊急入院となり、上部消化管内視鏡検査で十二指腸内腔に微小な穴が認められた。CTでは、腫瘍の著しい退縮と十二指腸狭窄が認められた。リンパ節も著明に縮小していたことから、根治切除が可能であると判断し、腹腔鏡下十二指腸部分切除術とリンパ節郭清を行った。術後経過は順調で、病理学的完全奏効を達成した。生検でMSI-Hが検出されたこと、子宮癌の既往があること、近親者に癌の既往があることから、Lynch症候群(LS)が疑われた。患者の末梢血を用いて遺伝子検査を行ったところ、MSH2遺伝子のNM_000251.3:c.211+1G>Cに変異が認められ、LSと診断した。

  • Guidelines for Handling of Cytological Specimens in Cancer Genomic Medicine

    Morii, E; Hatanaka, Y; Motoi, N; Kawahara, A; Hamakawa, S; Kuwata, T; Nagatomo, T; Oda, Y; Okamoto, A; Tanaka, R; Iyoda, A; Ichiro, M; Matsuo, Y; Nakamura, N; Nakai, T; Fukuhara, M; Tokita, K; Yamaguchi, T; Takenaka, M; Kawabata, A; Hatanaka, KC; Tsubame, K; Satoh, Y

    PATHOBIOLOGY   90 ( 5 )   289 - 311   2023年10月   ISSN:1015-2008 eISSN:1423-0291

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    記述言語:英語   出版者・発行元:Pathobiology  

    Rapid advances are being made in cancer drug therapy. Since molecularly targeted therapy has been introduced, personalized medicine is being practiced, pathological tissue from malignant tumors obtained during routine practice is frequently used for genomic testing. Whereas cytological specimens fixed mainly in alcohol are considered to be more advantageous in terms of preservation of the nucleic acid quality and quantity. This article is aimed to share the information for the proper handling of cytological specimens in practice for genomic medicine based on the findings established in "Guidelines for Handling of Cytological Specimens in Cancer Genomic Medicine (in Japanese)"published by the Japanese Society of Clinical Cytology in 2021. The three-part practical guidelines are based on empirical data analyses; Part 1 describes general remarks on the use of cytological specimens in cancer genomic medicine, then Part 2 describes proper handling of cytological specimens, and Part 3 describes the empirical data related to handling of cytological specimens. The guidelines indicated proper handling of specimens in each fixation, preparation, and evaluation.

    DOI: 10.1159/000528346

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  • HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and Oropharynx With Multisite Involvement. 査読 国際誌

    Kuga R, Yamamoto H, Jiromaru R, Hongo T, Yasumatsu R, Matsuo M, Hashimoto K, Taniguchi M, Nakagawa T, Oda Y.

    Am J Surg Pathol.   47 ( 9 )   955 - 966   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1097/PAS.0000000000002086.

  • Intratumor Fusobacterium nucleatum promotes the progression of pancreatic cancer via the CXCL1-CXCR2 axis. 査読 国際誌

    Hayashi M, Ikenaga N, Nakata K, Luo H, Zhong P, Date S, Oyama K, Higashijima N, Kubo A, Iwamoto C, Torata N, Abe T, Yamada Y, Ohuchida K, Oda Y, Nakamura M.

    Cancer Sci.   114 ( 9 )   3666 - 3678   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/cas.15901.

  • High-grade serous carcinoma can show squamoid morphology mimicking true squamous differentiation. 査読 国際誌

    Tomonobe H, Ohishi Y, Hachisuga K, Yahata H, Kato K, Oda Y.

    Am J Surg Pathol.   47 ( 9 )   967 - 976   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1097/PAS.0000000000002089.

  • Klotho overexpression is frequently associated with upstream rearrangements in fusion-negative phosphaturic mesenchymal tumors of bone and sinonasal tract. 査読 国際誌

    Lee JC, Hsieh TH, Kao YC, Tsai CF, Huang HY, Shih CY, Song HL, Oda Y, Chen PC, Pan CC, Sittampalam K, Petersson F, Konishi E, Chiu WY, Chen CF, Carpenter TO, Lu TP, Chang CD, Huang SC, Folpe AL.

    Mod Pathol.   36 ( 12 )   100336   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.modpat.2023.100336

  • Upregulated Fcrl5 disrupts B cell anergy causes autoimmune disease. 査読 国際誌

    Ono C, Tanaka S, Myouzen K, Iwasaki T, Ueda M, Oda Y, Yamamoto K, Kochi Y, Baba Y.

    Front Immunol.   14   1276014   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.3389/fimmu.2023.1276014.

  • Granzyme B Expression in the Tumor Microenvironment as a Prognostic Biomarker for Patients with Triple-Negative Breast Cancer. 査読 国際誌

    Mizoguchi K, Kawaji H, Kai M, Morisaki T, Hayashi S, Takao Y, Yamada M, Shimazaki A, Osako T, Arima N, Okido M, Oda Y, Nakamura M, Kubo M.

    Cancers (Basel).   15 ( 18 )   4456   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.3390/cancers15184456.

  • Intratumor <i>Fusobacterium nucleatum</i> promotes the progression of pancreatic cancer via the CXCL1-CXCR2 axis

    Hayashi, M; Ikenaga, N; Nakata, K; Luo, HZ; Zhong, PS; Date, S; Oyama, K; Higashijima, N; Kubo, A; Iwamoto, C; Torata, N; Abe, T; Yamada, Y; Ohuchida, K; Oda, Y; Nakamura, M

    CANCER SCIENCE   114 ( 9 )   3666 - 3678   2023年9月   ISSN:1347-9032 eISSN:1349-7006

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    記述言語:英語   出版者・発行元:Cancer Science  

    Intratumor bacteria modify the tumor immune microenvironment and influence outcomes of various tumors. Periodontal pathogen Fusobacterium nucleatum has been detected in pancreatic cancer tissues and is associated with poor prognosis. However, it remains unclear how F. nucleatum affects pancreatic cancer. Here, we compared clinical features with F. nucleatum colonization in pancreatic cancer tissues. F. nucleatum was detected in 15.5% (13/84) of pancreatic cancer patients. The tumor size was significantly larger in the F. nucleatum-positive group than in the negative group. To clarify the biological effect of intratumor F. nucleatum on pancreatic cancer progression, we performed migration/invasion assays and cytokine array analysis of cancer cells cocultured with F. nucleatum. F. nucleatum promoted CXCL1 secretion from pancreatic cancer cells, leading to cancer progression through autocrine signaling. Intratumor F. nucleatum suppressed tumor-infiltrating CD8+ T cells by recruiting myeloid-derived suppressor cells (MDSCs) to the tumor in an F. nucleatum-injected subcutaneous pancreatic cancer mouse model, resulting in tumor progression. Furthermore, tumor growth accelerated by F. nucleatum was suppressed by MDSC depletion or cytokine inhibitors. Intratumor F. nucleatum promoted pancreatic cancer progression through autocrine and paracrine mechanisms of the CXCL1-CXCR2 axis. Blockade of the CXCL1-CXCR2 axis may be a novel therapeutic approach for patients with intratumor F. nucleatum-positive pancreatic cancer.

    DOI: 10.1111/cas.15901

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  • Modulation of host glutamine anabolism of small cell lung cancer to chemotherapy

    Kodama, M; Toyokawa, G; Sugahara, O; Sugiyama, S; Haratake, N; Yamada, Y; Wada, R; Takamori, S; Shimokawa, M; Takenaka, T; Tagawa, T; Kittaka, H; Tsuruda, T; Tanaka, K; Komatsu, Y; Nakata, K; Imado, Y; Yamazaki, K; Okamoto, I; Oda, Y; Takahashi, M; Izumi, Y; Bamba, T; Shimizu, H; Yoshizumi, T; Nakayama, KI

    CELL REPORTS   42 ( 8 )   112899   2023年8月   ISSN:2211-1247

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    記述言語:英語   出版者・発行元:Cell Reports  

    Small cell lung cancer (SCLC) is one of the deadliest human cancers, with a 5-year survival rate of ∼7%. Here, we performed a targeted proteomics analysis of human SCLC samples and thereby identified hypoxanthine phosphoribosyltransferase 1 (HPRT1) in the salvage purine synthesis pathway as a factor that contributes to SCLC malignancy by promoting cell survival in a glutamine-starved environment. Inhibition of HPRT1 by 6-mercaptopurine (6-MP) in combination with methotrexate (MTX), which blocks the de novo purine synthesis pathway, attenuated the growth of SCLC in mouse xenograft models. Moreover, modulation of host glutamine anabolism with the glutamine synthetase inhibitor methionine sulfoximine (MSO) in combination with 6-MP and MTX treatment resulted in marked tumor suppression and prolongation of host survival. Our results thus suggest that modulation of host glutamine anabolism combined with simultaneous inhibition of the de novo and salvage purine synthesis pathways may be of therapeutic benefit for SCLC.

    DOI: 10.1016/j.celrep.2023.112899

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  • Design activities of ECH/CD system for JA DEMO

    Oda Y., Nagasaki K., Fukuyama A., Maekawa T., Idei H., Yanagihara K., Aiba N., Ikeda R., Kajiwara K., Kubo S., Seino T., Tobita K., Uto H., Sakamoto Y.

    AIP Conference Proceedings   2984 ( 1 )   2023年8月   ISSN:0094243X

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    出版者・発行元:AIP Conference Proceedings  

    JA DEMO is a steady-state tokamak which produces several hundreds of MW of electric power. Electron cyclotron heating and current drive (ECH/CD) system is one of the major components of JA DEMO tokamak, and it is expected to play an important role in its plasma operation scenario. Design activities for JA DEMO ECH/CD are in progress regarding both physics and engineering. Analysis of ECCD physics for current drive efficiency improvement shows that an upper-side injection can produce sufficient driven current by avoiding absorption at second harmonic resonance. RF power for ECCD operation of JA DEMO is expected to be 100 MW at the frequency of >200 GHz range. The conceptual design of the RF power plant represents the location and scale of the building for the RF power plant. The transmission Line (TL) for RF power delivery from the RF power plant to the tokamak exceeds 200 m, and studies of TL components for highly efficient RF transmission are in progress. The concept of the launcher, which combines remote steering technology and phased array, is evaluated by a simulation. A low-power experiment and preliminary results demonstrate that the large oblique angle injection necessary for ECCD operation is possible.

    DOI: 10.1063/5.0162701

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  • Clinicopathological features and genetic alterations in mixed-type ampullary carcinoma. 査読 国際誌

    Kawata J, Koga Y, Noguchi S, Shimada Y, Yamada Y, Yamamoto T, Shindo K, Nakamura M, Oda Y.

    Mod Pathol.   36 ( 8 )   100181   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.modpat.2023.100181.

  • Immune checkpoint status and oncogenic mutation profiling of rectal cancer after neoadjuvant chemotherapy (KSCC1301-A2). 査読 国際誌

    Miyashita Y, Oki E, Kamori T, Akagi Y, Mori S, Hattori N, Kobayashi K, Shimokawa M, Oda Y, Mori M.

    Ann Gastroenterol Surg.   8 ( 2 )   251 - 261   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1002/ags3.12730

  • Clinical significance of mechanistic target of rapamycin expression in vessels that encapsulate tumor cluster-positive hepatocellular carcinoma patients who have undergone living donor liver transplantation. 査読 国際誌

    Toshida K, Itoh S, Toshima T, Yoshiya S, Goto R, Mita A, Harada N, Kohashi K, Oda Y, Yoshizumi T.

    Ann Gastroenterol Surg.   8 ( 1 )   163 - 171   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1002/ags3.12735

  • Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy. 査読 国際誌

    Kodama M, Toyokawa G, Sugahara O, Sugiyama S, Haratake N, Yamada Y, Wada R, Takamori S, Shimokawa M, Takenaka T, Tagawa T, Kittaka H, Tsuruda T, Tanaka K, Komatsu Y, Nakata K, Imado Y, Yamazaki K, Okamoto I, Oda Y, Takahashi M, Izumi Y, Bamba T, Shimizu H, Yoshizumi T, Nakayama KI.

    Cell Rep.   42 ( 8 )   112899   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.celrep.2023.112899.

  • Evaluation of appropriate conditions for Oncomine DxTT testing of FFPE specimens for driver gene alterations in non-small cell lung cancer. 査読 国際誌

    Iwama E, Yamamoto H, Okubo F, Ijichi K, Ibusuki R, Shiaraishi Y, Yoneshima Y, Tanaka K, Oda Y, Okamoto I.

    Thorac Cancer.   14 ( 23 )   2288 - 2296   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/1759-7714.15014.

  • Involvement of angiogenesis in cancer-associated acinar-to-ductal metaplasia lesion of pancreatic cancer invasive front. 査読 国際誌

    Fei S, Ohuchida K, Kibe S, Yan Z, Iwamoto C, Shinkawa T, Zhang B, Kawata J, Abe T, Ideno N, Ikenaga N, Nakata K, Oda Y, Nakamura M.

    J Cancer Res Clin Oncol.   149 ( 9 )   5885 - 5899   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00432-022-04554-5.

  • Diagnostic utility of ERG immunostaining in dermatofibroma. 招待 査読 国際誌

    J Clin Pathol.   76 ( 8 )   536 - 540   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1136/jclinpath-2022-208158.

  • Clinical significance of the expression of FOXP3 and TIGIT in Merkel cell carcinoma. 査読 国際誌

    Iwasaki T, Hayashi K, Matsushita M, Nonaka D, Matsumoto T, Taniguchi M, Kuwamoto S, Umekita Y, Oda Y.

    Sci Rep.   13 ( 1 )   13114   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41598-023-40050-7.

  • Preoperative HALP score is a prognostic factor for intrahepatic cholangiocarcinoma patients undergoing curative hepatic resection: association with sarcopenia and immune microenvironment. 査読 国際誌

    Toshida K, Itoh S, Nakayama Y, Tsutsui Y, Kosai-Fujimoto Y, Tomino T, Yoshiya S, Nagao Y, Harada N, Kohashi K, Oda Y, Yoshizumi T.

    Int J Clin Oncol.   28 ( 8 )   1082 - 1091   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s10147-023-02358-2.

  • Clinical association between intraoperative indocyanine green fluorescence imaging pattern, preoperative Gd-EOB-DTPA-enhanced magnetic resonance imaging findings, and histological differentiation in hepatocellular carcinoma. 査読 国際誌

    Tomino T, Itoh S, Fujita N, Okamoto D, Nakayama Y, Toshida K, Tomiyama T, Tsutsui Y, Kosai Y, Kurihara T, Nagao Y, Morita K, Harada N, Ushijima Y, Kohashi K, Ishigami K, Oda Y, Yoshizumi T.

    Hepatol Res.   53 ( 8 )   723 - 736   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/hepr.13902.

  • Clinicopathologic Features and Genetic Alterations in Mixed-Type Ampullary Carcinoma

    Kawata, J; Koga, Y; Noguchi, S; Shimada, Y; Yamada, Y; Yamamoto, T; Shindo, K; Nakamura, M; Oda, Y

    MODERN PATHOLOGY   36 ( 8 )   100181   2023年8月   ISSN:0893-3952 eISSN:1530-0285

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    記述言語:英語   出版者・発行元:Modern Pathology  

    Mixed-type ampullary carcinoma is a subtype that combines intestinal-type (I-type) and pancreatobiliary-type (PB-type) lesions, but few studies have examined its clinicopathologic features and genetic alterations. The differences in genetic alterations between mixed type and other subtypes, as well as the genetic differences between I-type and PB-type lesions in the mixed type, remain unclear. In this study, we compared the clinicopathologic features and prognosis of 110 ampullary carcinomas classified by hematoxylin and eosin and immunohistochemical staining as follows: 63 PB-type, 35 I-type, and 12 mixed-type carcinomas. A comparative analysis of genetic mutations by targeted sequencing of 24 genes was also performed in 3 I-type cases, 9 PB-type cases, and I and PB-type lesions of 6 mixed-type cases. The mixed subtype had a poorer prognosis than the other subtypes, and there was also a similar tendency in the adjuvant group (n = 22). A total of 49 genetic mutations were detected in all 18 lesions for which genetic alteration was analyzed. No genetic mutations specific to the mixed type were found, and it was not possible to determine genetically whether the mixed type had originally been I or PB type. However, 5 of 6 cases had mutations common to both I and PB-type lesions, and additional mutations were found only in either I or PB-type lesions. In support of this, the mixed type more frequently exhibited genetic heterogeneity intratumorally than the other subtypes. Mixed-type tumors are histologically, immunohistochemically, and genetically heterogeneous, and this heterogeneity is associated with poor prognosis and may affect treatment resistance.

    DOI: 10.1016/j.modpat.2023.100181

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  • Immune checkpoint status and oncogenic mutation profiling of rectal cancer after neoadjuvant chemotherapy (KSCC1301-A2) 査読

    Miyashita, Y; Oki, E; Kamori, T; Akagi, Y; Mori, S; Hattori, N; Kobayashi, K; Shimokawa, M; Oda, Y; Mori, M

    ANNALS OF GASTROENTEROLOGICAL SURGERY   8 ( 2 )   251 - 261   2023年8月   ISSN:2475-0328

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    記述言語:英語   出版者・発行元:Annals of Gastroenterological Surgery  

    Aim: Immune checkpoint inhibitors (ICIs) are less effective in mismatch repair (MMR)-proficient (pMMR) colorectal cancers (CRCs) than in MMR-deficient CRCs. Here, we investigated changes in the tumor microenvironment after neoadjuvant chemotherapy (NAC) without radiotherapy in locally advanced rectal cancer (LARC) and the potential of ICIs as therapeutic agents for pMMR CRCs. Methods: This was an ad hoc analysis of a KSCC1301 randomized phase II trial in which patients with untreated resectable LARC were randomly assigned to receive S-1 and oxaliplatin or folinic acid, 5-fluorouracil, and oxaliplatin as NAC. Forty-nine patients were studied in this ad hoc analysis. As a reference cohort, we assessed 25 rectal cancer patients who underwent surgery without NAC outside the randomized trial. Immune checkpoint molecules (ICMs; PD-1, PD-L1, CTLA-4, LAG3), tumor-infiltrating lymphocytes (TILs; CD8, FOXP3), and other related proteins were evaluated by immunohistochemistry. Next-generation sequencing (NGS) using Oncomine™ Comprehensive Assay version 3 was conducted in 23 patients. Results: The expression levels of PD-1, CTLA-4, and LAG3 in the NAC group were significantly higher than in reference patients (p < 0.001). Additionally, the infiltration of CD8+ and FOXP3+ T cells, and the CD8/FOXP3 ratio were significantly higher in the NAC group than in reference patients (p < 0.0001). NGS analysis revealed no specific gene alteration related to TILs or ICMs. Conclusion: We demonstrated changes in the tumor immune microenvironment after NAC in pMMR rectal cancer. NAC was associated with increased expression of ICMs and TILs. Rectal cancer could be susceptible to combined immunotherapy with chemotherapy.

    DOI: 10.1002/ags3.12730

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  • Clinical significance of mechanistic target of rapamycin expression in vessels that encapsulate tumor cluster-positive hepatocellular carcinoma patients who have undergone living donor liver transplantation 査読

    Toshida, K; Itoh, S; Toshima, T; Yoshiya, S; Goto, R; Mita, A; Harada, N; Kohashi, K; Oda, Y; Yoshizumi, T

    ANNALS OF GASTROENTEROLOGICAL SURGERY   8 ( 1 )   163 - 171   2023年8月   ISSN:2475-0328

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    記述言語:英語   出版者・発行元:Annals of Gastroenterological Surgery  

    Background: There is limited published information regarding the expression of mechanistic target of rapamycin (mTOR) in vessels that encapsulate tumor cluster (VETC)-positive hepatocellular carcinoma (HCC). The mTOR inhibitor, everolimus, has been approved as an immunosuppressant for use in HCC patients after living donor liver transplantation (LDLT). Methods: Using a database of 214 patients who underwent LDLT for HCC, we examined the mTOR protein and angiopoietin-2 (Ang-2) in VETC-positive HCC by immunohistochemical staining. The presence of VETC and mTOR expression were evaluated in both primary and recurrent HCC lesions. Results: Forty-three of the 214 patients (20.1%) were VETC-positive, and 29 of these 43 patients (67.4%) expressed mTOR. Relative Ang-2 expression was significantly higher in the mTOR-positive than in the mTOR-negative group (p = 0.037). Thirty-four of the 214 patients experienced HCC recurrence after LDLT; 20 of these were operable. The primary lesions of six of these 20 patients were VETC-positive; five of these six patients also had VETC-positive recurrent lesions (p < 0.001). The expression of mTOR was significantly higher in the VETC-positive lesions (p = 0.0018). Conclusions: We showed that mTOR expression was higher in the VETC-positive primary and recurrent lesions than in the VETC-negative ones.

    DOI: 10.1002/ags3.12735

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  • Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics

    Thaler, R; Yoshizaki, K; Nguyen, T; Fukumoto, S; Den Besten, P; Bikle, DD; Oda, Y

    COMMUNICATIONS BIOLOGY   6 ( 1 )   766   2023年7月   eISSN:2399-3642

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    記述言語:英語   出版者・発行元:Communications Biology  

    Postnatal cell fate is postulated to be primarily determined by the local tissue microenvironment. Here, we find that Mediator 1 (Med1) dependent epigenetic mechanisms dictate tissue-specific lineage commitment and progression of dental epithelia. Deletion of Med1, a key component of the Mediator complex linking enhancer activities to gene transcription, provokes a tissue extrinsic lineage shift, causing hair generation in incisors. Med1 deficiency gives rise to unusual hair growth via primitive cellular aggregates. Mechanistically, we find that MED1 establishes super-enhancers that control enamel lineage transcription factors in dental stem cells and their progenies. However, Med1 deficiency reshapes the enhancer landscape and causes a switch from the dental transcriptional program towards hair and epidermis on incisors in vivo, and in dental epithelial stem cells in vitro. Med1 loss also provokes an increase in the number and size of enhancers. Interestingly, control dental epithelia already exhibit enhancers for hair and epidermal key transcription factors; these transform into super-enhancers upon Med1 loss suggesting that these epigenetic mechanisms cause the shift towards epidermal and hair lineages. Thus, we propose a role for Med1 in safeguarding lineage specific enhancers, highlight the central role of enhancer accessibility in lineage reprogramming and provide insights into ectodermal regeneration.

    DOI: 10.1038/s42003-023-05105-5

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  • The Factors Associated with the Selection of Early Excision Surgery for Congenital Biliary Dilatation with a Prenatal Diagnosis. 査読 国際誌

    Shirai T, Matsuura T, Tamaki A, Kajihara K, Uchida Y, Kawano Y, Toriigahara Y, Obata S, Kawakubo N, Yoshimaru K, Yanagi Y, Nagata K, Kohashi K, Oda Y, Tajiri T.

    J Pediatr Surg.   58 ( 7 )   1246 - 1251   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.jpedsurg.2023.01.050.

  • 胆管癌に対する胆汁、胆管擦過細胞診の診断精度に関する後方視的検討 査読

    並河真美、大久保文彦、山口知彦、野上美和子、山本猛雄、岩崎健、藤森尚、仲田興平、中村雅史、小田義直

    日本臨床細胞学会九州連合会雑誌   54   39 - 44   2023年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Histological and immunohistochemical prognostic factors of primary angiosarcoma. 査読 国際誌

    Ichiki T, Yamada Y, Ito T, Nakahara T, Nakashima Y, Nakamura M, Yoshizumi T, Shiose A, Akashi K, Oda Y.

    Virchows Arch.   483 ( 1 )   59 - 69   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00428-023-03572-z.

  • Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma. 査読 国際誌

    Ishihara S, Iwasaki T, Kohashi K, Kawaguchi K, Toda Y, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Oda Y.

    J Cancer Res Clin Oncol.   149 ( 6 )   2425 - 2436   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00432-022-04078-y.

  • MAML3 contributes to induction of malignant phenotype of gallbladder cancer through morphogenesis signalling under hypoxia. 査読 国際誌

    Anticancer Res.   43 ( 7 )   2909 - 2922   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.21873/anticanres.16462.

  • Prognostic impact of noninvasive areas in resected pathological stage IA lung adenocarcinoma. 査読 国際誌

    Kinoshita F, Shimokawa M, Takenaka T, Okamoto T, Taguchi K, Oda Y, Yoshizumi T.

    Thorac Cancer.   14 ( 18 )   1651 - 1569   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/1759-7714.14910.

  • Clinical significance of signal regulatory protein alpha (SIRPα) expression in hepatocellular carcinoma. 査読 国際誌

    Tomiyama T, Itoh S, Iseda N, Toshida K, Kosai-Fujimoto Y, Tomino T, Kurihara T, Nagao Y, Morita K, Harada N, Liu YC, Ozaki D, Kohashi K, Oda Y, Mori M, Yoshizumi T.

    Ann Surg Oncol.   30 ( 6 )   3378 - 3389   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-022-13058-y.

  • Preventive effect of tertiary lymphoid structures on lymph node metastasis of lung adenocarcinoma. 査読 国際誌

    Wakasu S, Tagawa T, Haratake N, Kinoshita F, Oku Y, Ono Y, Takenaka T, Oda Y, Shimokawa M, Mori M.

    Cancer Immunol Immunother.   72 ( 6 )   1823 - 1834   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00262-022-03353-8.

  • Artificial intelligence-based prediction of recurrence after curative resection for colorectal cancer from digital pathological images. 査読 国際誌

    Nakanishi R, Morooka K, Omori K, Toyota S, Tanaka Y, Hasuda H, Koga N, Nonaka K, Hu Q, Nakaji Y, Nakanoko T, Ando K, Ota M, Kimura Y, Oki E, Oda Y, Yoshizumi T.

    Ann Surg Oncol.   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1245/s10434-022-12926-x.

  • Artificial Intelligence-Based Prediction of Recurrence After Curative Resection for Colorectal Cancer From a Digital Pathologic Image

    Nakanishi, R; Morooka, K; Omori, K; Toyota, S; Tanaka, Y; Hasuda, H; Koga, N; Nonaka, K; Hu, QJ; Nakaji, Y; Nakanoko, T; Ando, K; Ota, M; Kimura, Y; Oki, E; Oda, Y; Yoshizumi, T

    ANNALS OF SURGICAL ONCOLOGY   30 ( 6 )   3515 - 3516   2023年6月   ISSN:1068-9265 eISSN:1534-4681

  • Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

    Tamura, T; Ito, J; Uriu, K; Zahradnik, J; Kida, I; Anraku, Y; Nasser, H; Shofa, M; Oda, Y; Lytras, S; Nao, N; Itakura, Y; Deguchi, S; Suzuki, R; Wang, L; Begum, MMST; Kita, S; Yajima, H; Sasaki, J; Sasaki-Tabata, K; Shimizu, R; Tsuda, M; Kosugi, Y; Fujita, S; Pan, L; Sauter, D; Yoshimatsu, K; Suzuki, S; Asakura, H; Nagashima, M; Sadamasu, K; Yoshimura, K; Yamamoto, Y; Nagamoto, T; Schreiber, G; Maenaka, K; Hashiguchi, T; Ikeda, T; Fukuhara, T; Saito, A; Tanaka, S; Matsuno, K; Takayama, K; Sato, K

    NATURE COMMUNICATIONS   14 ( 1 )   2800   2023年5月   eISSN:2041-1723

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    記述言語:英語   出版者・発行元:Nature Communications  

    In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions.

    DOI: 10.1038/s41467-023-38435-3

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  • Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

    Ito, J; Suzuki, R; Uriu, K; Itakura, Y; Zahradnik, J; Kimura, KT; Deguchi, S; Wang, L; Lytras, S; Tamura, T; Kida, I; Nasser, H; Shofa, M; Begum, MM; Tsuda, M; Oda, Y; Suzuki, T; Sasaki, J; Sasaki-Tabata, K; Fujita, S; Yoshimatsu, K; Ito, H; Nao, N; Asakura, H; Nagashima, M; Sadamasu, K; Yoshimura, K; Yamamoto, Y; Nagamoto, T; Kuramochi, J; Schreiber, G; Saito, A; Matsuno, K; Takayama, K; Hashiguchi, T; Tanaka, S; Fukuhara, T; Ikeda, T; Sato, K; Suzuki, S; Kato, M; Ferdous, Z; Mouri, H; Shishido, K; Misawa, N; Kimura, I; Kosugi, Y; Lin, P; Suganami, M; Chiba, M; Yoshimura, R; Yasuda, K; Iida, K; Ohsumi, N; Strange, AP; Sauter, D; Nakagawa, S; Wu, JQ; Watanabe, Y; Sakamoto, A; Yasuhara, N; Nakajima, Y; Yajima, H; Shirakawa, K; Takaori-Kondo, A; Nagata, K; Kazuma, Y; Nomura, R; Horisawa, Y; Tashiro, Y; Kawa, Y; Irie, T; Kawabata, R; Shimizu, R; Takahashi, O; Ichihara, K; Motozono, C; Toyoda, M; Ueno, T; Shibatani, Y; Nishiuchi, T

    NATURE COMMUNICATIONS   14 ( 1 )   2671   2023年5月   eISSN:2041-1723

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    記述言語:英語   出版者・発行元:Nature Communications  

    In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These variants convergently acquired amino acid substitutions at critical residues in the spike protein, including residues R346, K444, L452, N460, and F486. Here, we characterize the convergent evolution of Omicron subvariants and the properties of one recent lineage of concern, BQ.1.1. Our phylogenetic analysis suggests that these five substitutions are recurrently acquired, particularly in younger Omicron lineages. Epidemic dynamics modelling suggests that the five substitutions increase viral fitness, and a large proportion of the fitness variation within Omicron lineages can be explained by these substitutions. Compared to BA.5, BQ.1.1 evades breakthrough BA.2 and BA.5 infection sera more efficiently, as demonstrated by neutralization assays. The pathogenicity of BQ.1.1 in hamsters is lower than that of BA.5. Our multiscale investigations illuminate the evolutionary rules governing the convergent evolution for known Omicron lineages as of 2022.

    DOI: 10.1038/s41467-023-38188-z

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  • Prognostic value of nuclear morphometry in myxoid liposarcoma. 査読 国際誌

    Kawaguchi K, Kohashi K, Iwasaki T, Yamamoto T, Ishihara S, Toda Y, Yamamoto H, Nakashima Y, Oda Y.

    Cancer Sci.   114 ( 5 )   2178 - 2188   2023年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/cas.15729.

  • Prognostic significance for recurrence of FGFR2 in intrahepatic cholangiocarcinoma patients undergoing curative hepatic resection. 査読 国際誌

    Hepatol Res.   53 ( 5 )   432 - 439   2023年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/hepr.13875.

  • Extracellular volume fraction determined by dual-layer spectral detector CT: Possible role in predicting the efficacy of preoperative neoadjuvant chemotherapy in pancreatic ductal adenocarcinoma. 査読 国際誌

    Fujita N, Ushijima Y, Itoyama M, Okamoto D, Ishimatsu K, Wada N, Takao S, Murayama R, Fujimori N, Nakata K, Nakamura M, Yamamoto T, Oda Y, Ishigami K.

    Eur J Radiol.   162   110756   2023年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.ejrad.2023.110756.

  • Prognostic significance for recurrence of fibroblast growth factor receptor 2 in intrahepatic cholangiocarcinoma patients undergoing curative hepatic resection

    Toshida, K; Itoh, S; Yugawa, K; Kosai, Y; Tomino, T; Yoshiya, S; Nagao, Y; Kayashima, H; Harada, N; Kohashi, K; Oda, Y; Yoshizumi, T

    HEPATOLOGY RESEARCH   53 ( 5 )   432 - 439   2023年5月   ISSN:1386-6346 eISSN:1872-034X

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    記述言語:英語   出版者・発行元:Hepatology Research  

    Aims: The fibroblast growth factor receptor 2 (FGFR2) fusion gene is frequently found as a genetic abnormality in the FGFR pathway in patients with intrahepatic cholangiocarcinoma (ICC). The FGFR fusion protein, produced from the FGFR fusion gene, is thought to cause tumor cell growth. To date, there have been few reports on the relationship between pathologic FGFR2 expression and prognosis in patients who have undergone hepatectomy for ICC, and on the relationship between FGFR2 and tumor-infiltrating lymphocytes (TILs). Methods and Results: We enrolled 92 patients who underwent hepatectomy for ICC and performed immunohistochemical staining for FGFR2 and cluster of differentiation 8, and hematoxylin and eosin staining for evaluating TILSs. The relationships between the FGFR2 and clinicopathological characteristics and outcomes were analyzed, and patients were classified into positive (n = 18) and negative (n = 74) FGFR2 groups. The FGFR2-positive group contained more men (p < 0.0001) and had lower serum albumin (p = 0.0355) and higher carcinoembryonic antigen (p = 0.0099). Furthermore, multivariable analyses revealed that the FGFR2-positive group had worse disease-free survival (DFS) (p = 0.0002). Multivariate analysis showed that the independent prognostic factors for DFS were maximum tumor size (≥5 cm) (p = 0.0011), tumor localization (perihilar type) (p = 0.0180), and FGFR2 positivity (p = 0.0029). There was no significant difference in TILs count between the two groups. Conclusion: We showed that FGFR2 high expression was an independent prognostic factor for recurrence of resected ICC.

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  • Comparison of Akt/mammalian target of rapamycin/4E-binding protein 1 pathway signal activation in round stromal and surface cells in patients with sclerosing pneumocytoma. 査読 国際誌

    Hashisako M, Iwasaki T, Matsumoto T, Yamada Y, Miyamoto T, Taniguchi M, Oishi C, Oda Y.

    Pathol Res Pract.   244   154384   2023年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.prp.2023.154384.

  • Ampullary neuroendocrine neoplasm: clinicopathological characteristics and novel endoscopic entity. 招待 査読 国際誌

    Matsumoto K, Fujimori N, Hata Y, Minoda Y, Murakami M, Teramatsu K, Takamatsu Y, Takeno A, Oono T, Ihara E, Nakata K, Nakamura M, Yamamoto T, Koga Y, Oda Y, Ito T, Ogawa Y.

    Dig Dis.   41 ( 2 )   316 - 324   2023年4月

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    DOI: doi: 10.1159/000525013.

  • Correlation between extended pelvic lymph node dissection and urinary incontinence at early phase after robot-assisted radical prostatectomy. 査読 国際誌

    Lee K, Shiota M, Takamatsu D, Ushijima M, Blas L, Okabe A, Kajioka S, Goto S, Kinoshita F, Matsumoto T, Monji K, Kashiwagi E, Inokuchi J, Oda Y, Eto M.

    Int J Urol.   30 ( 4 )   340 - 346   2023年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/iju.15119.

  • Prognostic impact of CD73/adenosine 2A receptor (A2AR) in renal cell carcinoma and immune microenvironmental status with sarcomatoid changes and rhabdoid features. 査読 国際誌

    Takamatsu D, Kiyozawa D, Kohashi K, Kinoshita F, Toda Y, Ishihara S, Eto M, Oda Y.

    Pathol Res Pract.   244   154423   2023年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.prp.2023.154423.

  • Interstitial pneumonia after regression by olaparib for neuroendocrine prostate cancer with <i>BRCA1</i> mutation: a case report

    Kaitsumaru, M; Shiota, M; Takamatsu, D; Blas, L; Matsumoto, T; Inokuchi, J; Oda, Y; Eto, M

    INTERNATIONAL CANCER CONFERENCE JOURNAL   12 ( 2 )   131 - 136   2023年4月   ISSN:2192-3183

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  • Pancreatoblastoma with a novel fusion gene of <i>IQSEC1-RAF1</i>

    Goto, H; Koga, Y; Kohashi, K; Ono, H; Takemoto, J; Matsuura, T; Tajiri, T; Ihara, K; Oda, Y; Ohga, S

    PEDIATRIC BLOOD & CANCER   70 ( 4 )   e30155   2023年4月   ISSN:1545-5009 eISSN:1545-5017

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    記述言語:英語   出版者・発行元:Pediatric Blood and Cancer  

    DOI: 10.1002/pbc.30155

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  • Heidenhain Variant of Sporadic Creutzfeldt-Jakob Disease with a Variety of Visual Symptoms: A Case Report with Autopsy Study

    Hisata, Y; Yamashita, S; Tago, M; Yoshimura, M; Nakasima, T; Nishi, TM; Oda, Y; Honda, H; Yamashita, SI

    AMERICAN JOURNAL OF CASE REPORTS   24   e938654   2023年3月   eISSN:1941-5923

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    記述言語:英語   出版者・発行元:American Journal of Case Reports  

    Objective: Background: Case Report: Conclusions: Rare disease Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal disease caused by the change of prion protein (PrP). Affected patients present with rapidly progressive cognitive dysfunction, myoclonus, or akinetic mutism. Diagnosing the Heidenhain variant of sCJD, which initially causes various visual symptoms, can be particularly difficult. A 72-year-old woman presented with a 2-to 3-month history of photophobia, blurring vision in both eyes. Seven days previously, she showed visual impairment of 20/2000 in both eyes. Left homonymous hemianopia and restricted downward movement of the left eye were observed with an intact pupillary light reflex and normal fundoscopy. On admission, her visual acuity was light perception. Cranial magnetic resonance imaging revealed no abnormality, and electroencephalography showed no periodic synchronous discharges. Cerebrospinal fluid examination on the sixth hospital day revealed tau and 14-3-3 protein with a positive result of real-time quak-ing-induced conversion. She thereafter developed myoclonus and akinetic mutism and died. Autopsy revealed thinning and spongiform change of the cerebral cortex of the right occipital lobe. Immunostaining showed syn-aptic-type deposits of abnormal PrP and hypertrophic astrocytes. Consequently, she was diagnosed with the Heidenhain variant of sCJD with both methionine/methionine type 1 and type 2 cortical form based on the western blot of cerebral tissue and PrP gene codon 129 polymorphism. When a patient presents with various progressive visual symptoms, even without typical findings of electro-encephalography or cranial magnetic resonance imaging, it is essential to suspect the Heidenhain variant of sCJD and perform appropriate cerebrospinal fluid tests.

    DOI: 10.12659/AJCR.938654

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  • High-risk HPV-related squamous cell carcinoma in the temporal bone: a rare but noteworthy subtype. 査読 国際誌

    Hongo T, Yamamoto H, Kuga R, Komune N, Miyazaki M, Tsuchihashi NA, Noda T, Matsumoto N, Oda Y, Nakagawa T.

    Virchows Arch.   482 ( 3 )   539 - 550   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00428-023-03497-7.

  • Neoadjuvant chemotherapy enhances anti-tumor immune response of tumor microenvironment in human esophageal squamous cell carcinoma. 査読 国際誌

    Okuda S, Ohuchida K, Nakamura S, Tsutsumi C, Hisano K, Mochida Y, Kawata J, Ohtsubo Y, Shinkawa T, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Moriyama T, Nakata K, Torisu T, Morisaki T, Kitazono T, Oda Y, Nakamura M.

    iScience.   26 ( 4 )   4106480   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.isci.2023.106480.

  • Cancer-associated fibroblasts promote tumor cell growth via miR-493-5p in intrahepatic cholangiocarcinoma. 査読 国際誌

    Cancer Sci.   114 ( 3 )   937 - 947   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/cas.15644.

  • Protocol for the 2ND-STEP study, Japan Clinical Oncology Group study JCOG1802: a randomized phase II trial of second-line treatment for advanced soft tissue sarcoma comparing trabectedin, eribulin and pazopanib. 査読 国際誌

    Endo M, Kataoka T, Fujiwara T, Tsukushi S, Takahashi M, Kobayashi E, Yamada Y, Tanaka T, Nezu Y, Hiraga H, Wasa J, Nagano A, Nakano K, Nakayama R, Hamada T, Kawano M, Torigoe T, Sakamoto A, Asanuma K, Morii T, Machida R, Sekino Y, Fukuda H, Oda Y, Ozaki T, Tanaka K.

    BMC Cancer.   23 ( 1 )   219   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1186/s12885-023-10693-w.

  • TFE3-immunopositive papillary renal cell carcinoma: A clinicopathological, immunohistochemical, and genetic study. 査読 国際誌

    Takamatsu D, Kohashi K, Kiyozawa D, Kinoshita F, Ieiri K, Baba M, Eto M, Oda Y.

    Pathol Res Pract.   242   154313   2023年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.prp.2023.154313.

  • Translocation of nuclear chromatin distribution to the periphery reflects dephosphorylated threonine-821/826 of the retinoblastoma protein (pRb) in T24 cells treated with Bacillus Calmette-Guérin. 査読 国際誌

    Uehara T, Watanabe S, Yamaguchi S, Eguchi N, Sakamoto N, Oda Y, Arimura H, Kaku T, Ohishi Y, Mizuno S.

    Cytotechnology.   75 ( 1 )   49 - 62   2023年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10616-022-00559-7.

  • Human epidermal growth factor receptor 3 serves as a novel therapeutic target for acral melanoma. 査読 国際誌

    Tanaka Y, Ito T, Kaku-Ito Y, Tanegashima K, Tsuji G, Kido-Nakahara M, Oda Y, Nakahara T.

    Cell Death Discov.   9 ( 1 )   54   2023年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41420-023-01358-5.

  • Clinical implications of FDG-PET in pancreatic ductal adenocarcinoma patients treated with neoadjuvant therapy. 査読 国際誌

    Ikenaga N, Nakata K, Hayashi M, Nakamura S, Abe T, Ideno N, Murakami M, Fujimori N, Fujita N, Isoda T, Baba S, Ishigami K, Oda Y, Nakamura M.

    J Gastrointest Surg.   27 ( 2 )   337 - 346   2023年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s11605-023-05591-2.

  • A newly proposed grading system of nuclear morphology and the molecular genetic background in myxoid liposarcoma

    Kawaguchi, K; Kohashi, K; Ishihara, S; Toda, Y; Iwasaki, T; Yamamoto, T; Endo, M; Matsumoto, Y; Oda, Y

    CANCER SCIENCE   114   266 - 266   2023年2月   ISSN:1347-9032 eISSN:1349-7006

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  • Translocation of nuclear chromatin distribution to the periphery reflects dephosphorylated threonine-821/826 of the retinoblastoma protein (pRb) in T24 cells treated with Bacillus Calmette-Guerin

    Uehara, T; Watanabe, S; Yamaguchi, S; Eguchi, N; Sakamoto, N; Oda, Y; Arimura, H; Kaku, T; Ohishi, Y; Mizuno, S

    CYTOTECHNOLOGY   75 ( 1 )   49 - 62   2023年2月   ISSN:0920-9069 eISSN:1573-0778

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    記述言語:英語   出版者・発行元:Cytotechnology  

    The standard treatment for non-muscle-invasive bladder cancer is intravesical Bacillus Calmette–Guérin (BCG) therapy, which is considered the only intravesical therapy that reduces the risk of progression to muscle-invasive cancer. BCG unresponsiveness, in which intravesical BCG therapy is ineffective, has become a problem. It is thus important to evaluate the effectiveness of BCG treatment for patients as soon as possible in order to identify the optimal therapy. Urine cytology is a noninvasive, easy, and cost-effective method that has been used during BCG treatment, but primarily only to determine benign or malignant status; findings concerning the efficacy of BCG treatment based on urine cytology have not been reported. We investigated the relationship between BCG exposure and nuclear an important criterion in urine cytology, i.e., nuclear chromatin patterns. We used three types of cultured cells to evaluate nuclear chromatin patterns and the cell cycle, and we used T24 cells to evaluate the phosphorylation of retinoblastoma protein (pRb) in six-times of BCG exposures. The results revealed that after the second BCG exposure, (i) nuclear chromatin is distributed predominantly at the nuclear periphery and (ii) the dephosphorylation of threonine-821/826 in pRb occurs. This is the first report of a dynamic change in the nuclear chromatin pattern induced by exposure to BCG. Molecular findings also suggested a relationship between this phenomenon and cell-cycle proteins. Although these results are preliminary, they contribute to our understanding of the cytomorphological changes that occur with BCG exposure.

    DOI: 10.1007/s10616-022-00559-7

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  • Epitranscriptomic controls in soft-tissue leiomyosarcoma

    Iwasaki, T; Matsumoto, T; Ichiki, T; Kohashi, K; Oda, Y

    CANCER SCIENCE   114   642 - 642   2023年2月   ISSN:1347-9032 eISSN:1349-7006

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  • Clinicopathological features and genetic alterations in histological subtypes of ampullary carcinoma

    Kawata, J; Koga, Y; Noguchi, S; Shimada, Y; Yamada, Y; Yamamoto, T; Oda, Y

    CANCER SCIENCE   114   406 - 406   2023年2月   ISSN:1347-9032 eISSN:1349-7006

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  • Challenges and Prospects for Establishment of a Central Pathology Network for Rare Cancer Control: Focusing on Sarcomas

    Oda, Y

    CANCER SCIENCE   114   1612 - 1612   2023年2月   ISSN:1347-9032 eISSN:1349-7006

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  • Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G plus cancer cells and SPP1+macrophages in colorectal cancer

    Ozato, Y; Kojima, Y; Kobayashi, Y; Hisamatsu, Y; Toshima, T; Yonemura, Y; Masuda, T; Kagawa, K; Goto, Y; Utou, M; Fukunaga, M; Gamachi, A; Imamura, K; Kuze, Y; Zenkoh, J; Suzuki, A; Niida, A; Hirose, H; Hayashi, S; Koseki, J; Oki, E; Fukuchi, S; Murakami, K; Tobo, T; Nagayama, S; Uemura, M; Sakamoto, T; Oshima, M; Doki, Y; Eguchi, H; Mori, M; Iwasaki, T; Oda, Y; Shibata, T; Suzuki, Y; Shimamura, T; Mimori, K

    CELL REPORTS   42 ( 1 )   111929   2023年1月   ISSN:2211-1247

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    記述言語:英語   出版者・発行元:Cell Reports  

    The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are poorly understood, hindering patient treatment. In the current study, we investigate whether events occurring at the invasion front are of particular importance for CRC treatment strategies. To this end, we analyze CRC tissues by combining spatial transcriptomics from patients with a public single-cell transcriptomic atlas to determine cell-cell interactions at the invasion front. We show that CRC cells are localized specifically at the invasion front. These cells induce human leukocyte antigen G (HLA-G) to produce secreted phosphoprotein 1 (SPP1)+ macrophages while conferring CRC cells with anti-tumor immunity, as well as proliferative and invasive properties. Taken together, these findings highlight the signaling between CRC cell populations and stromal cell populations at the cellular level.

    DOI: 10.1016/j.celrep.2022.111929

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  • Expression of SATB2, RUNX2, and SOX9 and possible osteoblastic and chondroblastic differentiation in chondroblastoma. 査読 国際誌

    Toda Y, Yamamoto H, Iwasaki T, Ishihara S, Ito Y, Susuki Y, Kawaguchi K, Kinoshita I, Kiyozawa D, Yamada Y, Kohashi K, Kimura A, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Mawatari M, Oda Y.

    Pathol Res Pract.   ( 241 )   154239   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.prp.2022.154239.

  • C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions. 査読 国際誌

    Nagao S, Onishi H, Kawamoto M, Masuda S, Na L, Morisaki S, Iwamoto N, Yamada Y, Koga S, Ichimiya S, Nakayama K, Imaizumi A, Nakashima K, Oda Y, Nakamura M.

    J Cancer.   14 ( 2 )   306 - 317   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.7150/jca.78993.

  • The expression of insulin-like growth factor II messenger RNA-binding protein 3 upregulated in intradural extramedullary schwannomas. 査読 国際誌

    Bekki H, Matsumoto Y, Yoshimoto M, Ishihara S, Kawaguchi K, Yamamoto H, Oda Y, Nakashima Y, Harimaya K.

    Spine Surg Relat Res.   7 ( 1 )   36 - 41   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.22603/ssrr.2022-0063.

  • Subcutaneous thyroid tissue implantation after thyroidectomy: a mimic of benign cutaneous tumours. 査読 国際誌

    Takei I, Ito T, Mori T, Oda Y, Nakahara T.

    Acta Derm Venereol.   103   adv00842   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.2340/actadv.v103.4407.

  • Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer. 査読 国際誌

    Ozato Y, Kojima Y, Kobayashi Y, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Kagawa K, Goto Y, Utou M, Fukunaga M, Gamachi A, Imamura K, Kuze Y, Zenkoh J, Suzuki A, Niida A, Hirose H, Hayashi S, Koseki J, Oki E, Fukuchi S, Murakami K, Tobo T, Nagayama S, Uemura M, Sakamoto T, Oshima M, Doki Y, Eguchi H, Mori M, Iwasaki T, Oda Y, Shibata T, Suzuki Y, Shimamura T, Mimori K.

    Cell Rep.   42 ( 1 )   111929   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.celrep.2022.111929.

  • Single-cell transcriptome analysis reveals functional changes in tumour-infiltrating B lymphocytes after chemotherapy in oesophageal squamous cell carcinoma. 査読 国際誌

    Nakamura S, Ohuchida K, Ohtsubo Y, Yamada Y, Tsutsumi C, Okuda S, Hisano K, Mochida Y, Shinkawa T, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Nakata K, Moriyama T, Torisu T, Nagai E, Morisaki T, Kitazono T, Oda Y, Nakamura M.

    Clin Transl Med.   13 ( 1 )   e1181   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1002/ctm2.1181.

  • C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions. 査読 国際誌

    Nagao S, Onishi H, Kawamoto M, Masuda S, Na L, Morisaki S, Iwamoto N, Yamada Y, Koga S, Ichimiya S, Nakayama K, Imaizumi A, Nakashima K, Oda Y, Nakamura M.

    J Cancer.   14 ( 2 )   306 - 317   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.7150/jca.78993.

  • Conformer-Based Lip-Reading for Japanese Sentence

    Arakane T., Saitoh T., Chiba R., Morise M., Oda Y.

    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)   13836 LNCS   474 - 485   2023年   ISSN:03029743 ISBN:9783031258244

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    出版者・発行元:Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)  

    Various applications of lip-reading technology are considered, and it is an important issue. In recent years, lip-reading research on sentences has attracted attention. However, most of the published datasets are English-talking scenes, and there are few datasets other than English. Therefore, in this research, we are researching Japanese sentence-level lip-reading. In this paper, we construct Japanese sentence utterance scene datasets ITA and ROHAN4600 and propose the Conformer-based lip-reading method. Recognition experiments were conducted using the Transformer model as a conventional method. As a result, it was confirmed that the Conformer model obtained high recognition accuracy both at the phoneme and the mora levels.

    DOI: 10.1007/978-3-031-25825-1_34

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  • Analysis of clinicopathological features and NAB2-STAT6 fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle. 査読 国際誌

    Shirakura T, Yamada Y, Nakata S, Asayama B, Seo Y, Tanikawa S, Kato T, Komoribayashi N, Kubo N, Monma N, Okura N, Tanaka S, Oda Y, Hirato J, Yokoo H, Nobusawa S.

    Virchows Arch.   481 ( 6 )   913 - 923   2022年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00428-022-03403-7.

  • Analysis of clinicopathological features and <i>NAB2</i>-<i>STAT6</i> fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle

    Shirakura, T; Yamada, Y; Nakata, S; Asayama, B; Seo, Y; Tanikawa, S; Kato, T; Komoribayashi, N; Kubo, N; Monma, N; Okura, N; Tanaka, S; Oda, Y; Hirato, J; Yokoo, H; Nobusawa, S

    VIRCHOWS ARCHIV   481 ( 6 )   913 - 923   2022年12月   ISSN:0945-6317 eISSN:1432-2307

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    記述言語:英語   出版者・発行元:Virchows Archiv  

    Solitary fibrous tumors (SFTs) are rare mesenchymal tumors that can occur at any location. Since the identification of specific NAB2-STAT6 fusion in SFTs, the fusion gene variants, NAB2 exon 4-STAT6 exon 2/3 and NAB2 exon 5/6/7-STAT6 exon 16/17/18, have been reported to be associated with clinicopathological features, and the latter variant is predominant in meningeal SFTs. SFTs developing in the salivary glands are rare, and more rarely, those involving ectopic salivary glands (ESGs) have been reported in the cerebellopontine angle (CPA); however, their characteristics remain not well understood. In this study, we performed a clinicopathological and molecular analysis of 3 cases of meningeal SFT with ESGs. All cases presented with an extra-axial mass in the CPA, which is a rarer location for intracranial ESGs compared to the sellar region. Histologically, except for the presence of ESGs, there was no significant difference between current cases and ordinary SFTs. The ESGs demonstrated no cellular atypia, and although the spindle tumor cells were immunopositive for STAT6, the ESGs were negative in all cases, supporting that the ESGs are non-neoplastic components. In 1 case, ESGs were found only in the primary tumor and disappeared in recurrence/dissemination. Of note, molecular analysis identified NAB2 exon 4-STAT6 exon 2 in all cases. In conclusion, our results suggest that ESGs particularly in the CPA may be associated with SFTs and that meningeal SFTs with ESGs may be associated with the minor fusion variant of NAB2-STAT6 in the intracranial lesions.

    DOI: 10.1007/s00428-022-03403-7

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  • Immunohistochemistry reveals an increased number of ganglion cells in the normal-size plexus, as a pathological feature of immaturity of ganglia

    Yoshimaru K., Miyoshi K., Kinoshita Y., Obata S., Yanagi Y., Takahashi Y., Kajihara K., Irie K., Uchida Y., Toriigahara Y., Kawano Y., Kohashi K., Yoshioka T., Nakazawa A., Matsuura T., Oda Y., Tajiri T., Taguchi T.

    Comparative Clinical Pathology   31 ( 6 )   951 - 957   2022年12月   ISSN:16185641

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    出版者・発行元:Comparative Clinical Pathology  

    Immaturity of ganglia (IG), is a rare entity of an allied disorder of Hirschsprung’s disease. We reviewed our IG cases to provide further pathological insight into IG. The clinical data and pathological findings of IG cases in our department from 2011 to 2020 were examined. Hematoxylin and eosin (HE) staining and immunostaining for HuC/D, BCL-2, SOX10, and CD56 were performed on full-thickness specimens. Sufficient clinical data and pathological specimens were available in five cases during the study period. The patient profiles were as follows: four term infants and one preterm infant with initial symptoms of abdominal distension or vomiting; all cases underwent ileostomy at a median age of 2 days and stoma closure at a median age of 5 months. Although the interpretation of HE staining was difficult, immunostaining for HuC/D and SOX10 clearly distinguished ganglion cells from glial cells. The number of ganglion cells in the IG group was significantly greater than that in the control group (p < 0.05), while the number of enteric glial cells and total area of the myenteric nerve plexus did not differ. The finding of the increased number of ganglion cells in a normal-size myenteric plexus is a novel feature of IG that contributes to its accurate diagnosis.

    DOI: 10.1007/s00580-022-03390-w

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  • Relationship between cellular morphology and abnormality of SWI/SNF complex subunits in pancreatic undifferentiated carcinoma. 査読 国際誌

    Yamamoto T, Kohashi K, Yamada Y, Kawata J, Sakihama K, Matsuda R, Koga Y, Aishima S, Nakamura M, Oda Y.

    J Cancer Res Clin Oncol.   148 ( 11 )   2945 - 2957   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00432-021-03860-8.

  • Association of thyroid transcription factor-1 (TTF-1) expression with efficacy of PD-1/PD-L1 inhibitors plus pemetrexed and platinum chemotherapy in advanced non-squamous non-small cell lung cancer. 査読 国際誌

    Ibusuki R, Yoneshima Y, Hashisako M, Matsuo N, Harada T, Tsuchiya-Kawano Y, Kishimoto J, Ota K, Shiraishi Y, Iwama E, Tanaka K, Oda Y, Okamoto I.

    Transl Lung Cancer Res.   11 ( 11 )   2208 - 2215   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.21037/tlcr-22-393.

  • A CASE OF MALIGNANT PERIVASCULAR EPITHELIOID CELL TUMOR (PEComa) OF THE VAGINA

    Hino, Y; Tamaki, A; Kawakubo, N; Hamada, H; Ono, H; Koga, Y; Kohashi, K; Oga, S; Oda, Y; Tajiri, T

    PEDIATRIC BLOOD & CANCER   69   2022年11月   ISSN:1545-5009 eISSN:1545-5017

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  • HISTOLOGICAL AND GENETIC ANALYSIS OF CONGENITAL MESOBLASTIC NEPHROMA

    Tamaki, A; Kawakubo, N; Hino, Y; Hamada, H; Takemoto, J; Oda, Y; Tajiri, T

    PEDIATRIC BLOOD & CANCER   69   2022年11月   ISSN:1545-5009 eISSN:1545-5017

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  • ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway (vol 22, pg 9, 2022)

    Guan, W; Nakata, K; Sagara, A; Iwamoto, C; Endo, S; Matsuda, R; Matsumoto, S; Ikenaga, N; Shindo, K; Moriyama, T; Onishi, H; Ohuchida, K; Oda, Y; Nakamura, M

    PANCREATOLOGY   22 ( 7 )   1059 - 1059   2022年11月   ISSN:1424-3903 eISSN:1424-3911

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    記述言語:英語   出版者・発行元:Pancreatology  

    Figures in this paper contained western blots where the same membrane was probed repeatedly by the indicated antibodies, occasionally resulting in similar band shapes among the individual panels. Moreover, in Figure 5, results from the same membrane were presented in two columns with the panels for the α-SMA and β-actin blots shown twice for easier comparison. We apologize for any misunderstanding this may have caused.

    DOI: 10.1016/j.pan.2022.08.013

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  • A CASE OF PULMONARY SCLEROSING PENUMOCYTOMA IN A 13-YEAR-OLD BOY

    Hamada, H; Kawakubo, N; Hino, Y; Tamaki, A; Kohashi, K; Oda, Y; Tajiri, T

    PEDIATRIC BLOOD & CANCER   69   2022年11月   ISSN:1545-5009 eISSN:1545-5017

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  • Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5

    Kimura, I; Yamasoba, D; Tamura, T; Nao, N; Suzuki, T; Oda, Y; Mitoma, S; Ito, J; Nasser, H; Zahradnik, J; Uriu, K; Fujita, S; Kosugi, Y; Wang, L; Tsuda, M; Kishimoto, M; Ito, H; Suzuki, R; Shimizu, R; Begum, MM; Yoshimatsu, K; Kimura, KT; Sasaki, J; Sasaki-Tabata, K; Yamamoto, Y; Nagamoto, T; Kanamune, J; Kobiyama, K; Asakura, H; Nagashima, M; Sadamasu, K; Yoshimura, K; Shirakawa, K; Takaori-Kondo, A; Kuramochi, J; Schreiber, G; Ishii, KJ; Hashiguchi, T; Ikeda, T; Saito, A; Fukuhara, T; Tanaka, S; Matsuno, K; Sato, K

    CELL   185 ( 21 )   3992 - +   2022年10月   ISSN:0092-8674 eISSN:1097-4172

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    記述言語:英語   出版者・発行元:Cell  

    After the global spread of the SARS-CoV-2 Omicron BA.2, some BA.2 subvariants, including BA.2.9.1, BA.2.11, BA.2.12.1, BA.4, and BA.5, emerged in multiple countries. Our statistical analysis showed that the effective reproduction numbers of these BA.2 subvariants are greater than that of the original BA.2. Neutralization experiments revealed that the immunity induced by BA.1/2 infections is less effective against BA.4/5. Cell culture experiments showed that BA.2.12.1 and BA.4/5 replicate more efficiently in human alveolar epithelial cells than BA.2, and particularly, BA.4/5 is more fusogenic than BA.2. We further provided the structure of the BA.4/5 spike receptor-binding domain that binds to human ACE2 and considered how the substitutions in the BA.4/5 spike play roles in ACE2 binding and immune evasion. Moreover, experiments using hamsters suggested that BA.4/5 is more pathogenic than BA.2. Our multiscale investigations suggest that the risk of BA.2 subvariants, particularly BA.4/5, to global health is greater than that of original BA.2.

    DOI: 10.1016/j.cell.2022.09.018

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  • Direct visualization of cooperative adsorption of a string-like molecule onto a solid

    Morimitsu, Y; Matsuno, H; Oda, Y; Yamamoto, S; Tanaka, K

    SCIENCE ADVANCES   8 ( 41 )   eabn6349   2022年10月   ISSN:2375-2548

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    記述言語:英語   出版者・発行元:Science Advances  

    Natural systems, composite materials, and thin-film devices adsorb macromolecules in different phases onto their surfaces. In general, polymer chains form interfacial layers where their aggregation states and thermal molecular motions differ from the bulk. Here, we visualize well-defined double-stranded DNAs (dsDNAs) using atomic force microscopy and molecular dynamics simulations to clarify the adsorption mechanism of polymer chains onto solid surfaces. Initially, short and long dsDNAs are individually and cooperatively adsorbed, respectively. Cooperative adsorption involves intertwining of multiple chains. The dependence of adsorption on the chain affects the formation of the interfacial layer, realizing different mechanical properties of DNA/filler bulk composites. These findings will contribute to the development of light and durable polymer composites and films for various industrial, biomedical, and environmental applications.

    DOI: 10.1126/sciadv.abn6349

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  • Hemiarthroplasty for tumor-induced osteomalacia caused by tumor localized in femoral head: a case report

    Arita, S; Nishino, T; Mitani, Y; Sakashita, K; Totsuka, S; Watanabe, R; Mishima, H; Kawai, H; Matsubara, D; Oda, Y; Yamazaki, M

    JOURNAL OF SURGICAL CASE REPORTS   2022 ( 10 )   rjac478   2022年10月   ISSN:2042-8812

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  • A novel fast kilovoltage switching dual-energy computed tomography technique with deep learning: utility for non-invasive assessments of liver fibrosis. 査読 国際誌

    Wada N, Fujita N, Ishimatsu K, Takao S, Yoshizumi T, Miyazaki Y, Oda Y, Nishie A, Ishigami K, Ushijima Y.

    Eur J Radiol.   155   110461   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.ejrad.2022.110461.

  • Chronological changes in the expression pattern of hippocampal prion proteins during disease progression in sporadic creutzfeldt-Jakob disease MM1 subtype. 査読 国際誌

    Yagita K, Noguchi H, Koyama S, Hamasaki H, Komori T, Aishima S, Kosaka T, Ueda M, Komohara Y, Watanabe A, Sasagasako N, Ninomiya T, Oda Y, Honda H.

    J Neuropathol Exp Neurol.   81 ( 11 )   900 - 909   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1093/jnen/nlac078.

  • A new scoring system for the grading of conventional chondrosarcoma: Its clinicopathological significance. 査読 国際誌

    Susuki Y, Yamada Y, Ito Y, Kawaguchi K, Furukawa H, Kohashi K, Kinoshita I, Taguchi K, Nakashima Y, Oda Y.

    Pathol Res Pract.   ( 238 )   154125   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.prp.2022.154125.

  • Solid-type poorly differentiated adenocarcinoma of the stomach: A characteristic morphology reveals a distinctive immunoregulatory tumor microenvironment. 査読 国際誌

    Kawatoko S, Kohashi K, Torisu T, Sasaki T, Umekita S, Oki E, Nakamura M, Kitazono T, Oda Y.

    Pathol Res Pract.   ( 238 )   154124   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.prp.2022.154124.

  • Denervation caused by extended pelvic lymph node dissection worsens early urinary continence after robot-assisted radical prostatectomy

    Lee, K; Shiota, M; Takamatsu, D; Ushijima, M; Okabe, A; Kajioka, S; Goto, S; Kinoshita, F; Matsumoto, T; Monji, K; Kashiwagi, E; Inokuchi, J; Oda, Y; Eto, M

    INTERNATIONAL JOURNAL OF UROLOGY   29   22 - 22   2022年10月   ISSN:0919-8172 eISSN:1442-2042

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  • Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant

    Saito, A; Tamura, T; Zahradnik, J; Deguchi, S; Tabata, K; Anraku, Y; Kimura, I; Ito, J; Yamasoba, D; Nasser, H; Toyoda, M; Nagata, K; Uriu, K; Kosugi, Y; Fujita, S; Shofa, M; Begum, MM; Shimizu, R; Oda, Y; Suzuki, R; Ito, H; Nao, N; Wang, L; Tsuda, M; Yoshimatsu, K; Kuramochi, J; Kita, S; Sasaki-Tabata, K; Fukuhara, H; Maenaka, K; Yamamoto, Y; Nagamoto, T; Asakura, H; Nagashima, M; Sadamasu, K; Yoshimura, K; Ueno, T; Schreiber, G; Takaori-Kondo, A; Shirakawa, K; Sawa, H; Irie, T; Hashiguchi, T; Takayama, K; Matsuno, K; Tanaka, S; Ikeda, T; Fukuhara, T; Sato, K

    CELL HOST & MICROBE   30 ( 9 )   1540 - +   2022年9月   ISSN:1931-3128 eISSN:1934-6069

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    記述言語:英語   出版者・発行元:Cell Host and Microbe  

    The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency, but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5.

    DOI: 10.1016/j.chom.2022.10.003

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  • M-CSFR expression in the embryonal component of hepatoblastoma and cell-to-cell interaction between macrophages and hepatoblastoma. 査読 国際誌

    Li L, Irie T, Yoshii D, Komohara Y, Fujiwara Y, Esumi S, Kadohisa M, Honda M, Suzu S, Matsuura T, Kohashi K, Oda Y, Hibi T.

    Med Mol Morphol.   55 ( 3 )   236 - 247   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00795-022-00323-y.

  • Immunohistochemistry reveals an increased number of ganglion cells in the normal‑size plexus, as a pathological feature of immaturity of ganglia. 査読 国際誌

    32 ( 5 )   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Targeting hepatic oxidative stress rescues bone loss in liver fibrosis. 査読 国際誌

    Sonoda S, Murata S, Yamaza H, Yuniartha R, Fujiyoshi J, Yoshimaru K, Matsuura T, Oda Y, Ohga S, Tajiri T, Taguchi T, Yamaza T.

    Mol Metab.   ( 66 )   101599   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.molmet.2022.101599.

  • Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy. 査読 国際誌

    Okuda S, Ohuchida K, Shindo K, Moriyama T, Kawata J, Tamura K, Sada M, Nagayoshi K, Mizuuchi Y, Ikenaga N, Nakata K, Oda Y, Nakamura M.

    Oncol Lett.   24 ( 3 )   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: DOI: 10.3892/ol.2022.13457

  • Neuroectodermal rosettes in immature teratomas are not the counterpart of embryonal tumours with multilayered rosettes. 査読 国際誌

    Magarifuchi N, Yamada Y, Oishi Y, Kato K, Taguchi K, Oda Y.

    Anticancer Res.   42 ( 9 )   4337 - 4344   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi:10.21873/anticanres.15934

  • Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model. 査読 国際誌

    Yamaguchi K, Yoshihiro T, Ariyama H, Ito M, Nakano M, Semba Y, Nogami J, Tsuchihashi K, Yamauchi T, Ueno S, Isobe T, Shindo K, Moriyama T, Ohuchida K, Nakamura M, Nagao Y, Ikeda T, Hashizume M, Konomi H, Torisu T, Kitazono T, Kanayama T, Tomita H, Oda Y, Kusaba H, Maeda T, Akashi K, Baba E.

    Gastric Cancer.   25 ( 5 )   862 - 878   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s10120-022-01307-8.

  • Pancreatic hamartoma: detection of harbouring NAB2-STAT6 fusion gene. 査読 国際誌

    Tanigawa M, Koga Y, Naito Y, Yamaguchi H, Iwasaki T, Kohashi K, Ohike N, Hanada K, Higashi M, Komatsu M, Imai H, Yamakita K, Nagakawa T, Okabe Y, Kato S, Noguchi H, Nakayama T, Yasuda M, Kusano H, Akiba J, Oda Y, Yano H.

    Histopathology.   81 ( 3 )   319 - 328   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/his.14703.

  • Pancreatic hamartoma: detection of harbouring <i>NAB2::STAT6</i> fusion gene

    Tanigawa, M; Koga, Y; Naito, Y; Yamaguchi, H; Iwasaki, T; Kohashi, K; Ohike, N; Hanada, K; Higashi, M; Komatsu, M; Imai, H; Yamakita, K; Nagakawa, T; Okabe, Y; Kato, S; Noguchi, H; Nakayama, T; Yasuda, M; Kusano, H; Akiba, J; Oda, Y; Yano, H

    HISTOPATHOLOGY   81 ( 3 )   319 - 328   2022年9月   ISSN:0309-0167 eISSN:1365-2559

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    記述言語:英語   出版者・発行元:Histopathology  

    Hamartomas in the pancreas are rare and are often histologically and morphologically similar to solitary fibrous tumours (SFTs). We examined the differences between hamartomas and SFTs at the molecular level. Methods and results: Thirteen patients histopathologically diagnosed with pancreatic hamartoma were included in the study. We also performed STAT6 immunohistochemistry (IHC), which is used in the diagnosis of SFT. Furthermore, for the three cases in which RNA was extracted, reverse transcription polymerase chain reaction to search for NAB2::STAT6 fusions was used. Macroscopically, 13 patients had well-demarcated tumour lesions. Histologically, no islets of Langerhans were observed in the lesions, acinar tissue and ducts were unevenly distributed and elastic fibres were not observed around the ducts by Elastica van Gieson staining. One case contained a lipomatous hamartoma composed mainly of adipose tissue. Seven of the 13 cases demonstrated expression of STAT6 in the nuclei of intervening spindle cells. NAB2::STAT6 fusions were observed in two of the three cases in which RNA was extracted. These two cases also demonstrated STAT6 expression in spindle cells using STAT6 IHC. In one case of lipomatous hamartoma, we did not confirm NAB2::STAT6 fusion or STAT6 expression in STAT6 IHC. Conclusion: Of the 13 patients histopathologically diagnosed with hamartoma, two demonstrated NAB2::STAT6 fusions, suggesting the existence of pancreatic hamartomas with molecular-level components identical to those of SFT.

    DOI: 10.1111/his.14703

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  • Panuveitis induced by donor-derived CD8<sup>+</sup> T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia

    Takeda A., Sakoda T., Yawata N., Kato K., Hasegawa E., Shima T., Hikita S., Yoshitomi K., Takenaka K., Oda Y., Akashi K., Sonoda K.H.

    American Journal of Ophthalmology Case Reports   27   101673   2022年9月   ISSN:24519936

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    記述言語:英語   出版者・発行元:American Journal of Ophthalmology Case Reports  

    Purpose: This article presents a case of panuveitis that occurred after unrelated allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a patient with lymphoma-type human T-cell leukemia virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL). Observations: A 45-year-old man developed unilateral panuveitis 18 months after undergoing allo-HSCT. He underwent vitrectomy, and depositions of grey-white granules localized on the retinal artery were observed in the eye. Cytological examination of the vitreous aspirates showed that the atypical lymphoid cells stained positive for CD3 and CD8, but negative for CD4, B-cell markers, and cytomegalovirus antigen. Interphase fluorescence in situ hybridization using X‐ and Y‐chromosome probes revealed complete donor chimerism in CD8+ T cells in the vitreous aspirates. Conclusions and importance: Donor-derived CD8+ T lymphocytes can induce panuveitis like HTLV-1-assiciated uveitis after allo-HSCT in patients with ATL. Pathological diagnosis of vitreous infiltration by vitrectomy is helpful in patients with ATL. Donor-derived CD8+ T lymphocytes-induced panuveitis is recurrent but susceptible to regional corticosteroid treatment.

    DOI: 10.1016/j.ajoc.2022.101673

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  • Tropomyosin-related Kinase B Is Potentially a Biomarker of Prognosis and Therapeutic Target for Malignant Thymic Epithelial Tumors. 査読 国際誌

    Ozono K, Onishi H, Iwamoto N, Nakamura K, Miyoshi K, Nakamura M, Oda Y.

    Anticancer Res.   42 ( 7 )   3779 - 3787   2022年8月

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  • Nuclear β-catenin translocation plays a key role in osteoblast differentiation of giant cell tumor of bone. 査読 国際誌

    12 ( 1 )   13438   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41598-022-17728-5.

  • Substantial improvement of histopathological diagnosis by whole-slide image-based remote consultation. 査読 国際誌

    Shinohara S, Bychkov A, Munkhdelger J, Kuroda K, Yoon HS, Fujimura S, Tabata K, Furusato B, Niino D, Morimoto S, Yao T, Itoh T, Aoyama H, Tsuyama N, Mikami Y, Nagao T, Ikeda T, Fukushima N, Harada O, Kiyokawa T, Yoshimi N, Aishima S, Maeda I, Mori I, amanegi K, Tsuneyama K, Katoh R, Izumi M, Oda Y, Fukuoka J.

    Virchows Arch.   481 ( 2 )   295 - 305   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00428-022-03327-2.

  • Relationship between consolidation tumor ratio and tumor-infiltrating lymphocytes in small-sized lung adenocarcinoma. 査読 国際誌

    Ono Y, Tagawa T, Kinoshita F, Haratake N, Takada K, Kohno M, Takenaka T, Kamitani T, Shimokawa M, Oda Y, Mori M, Yoshizumi T.

    Thorac Cancer.   13 ( 15 )   2134 - 2141   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/1759-7714.14524

  • Characteristics of colorectal neuroendocrine tumors in patients prospectively enrolled in a Japanese multicenter study: a first report from the C-NET STUDY

    Sekiguchi, M; Hotta, K; Takeuchi, Y; Tanaka, S; Yamamoto, H; Shinmura, K; Harada, K; Uraoka, T; Hisabe, T; Sano, Y; Kondo, H; Horimatsu, T; Kikuchi, H; Kawamura, T; Nagata, S; Yamamoto, K; Tajika, M; Tsuji, S; Kusaka, T; Okuyama, Y; Yoshida, N; Moriyama, T; Hasebe, A; So, S; Kobara, H; Kashida, H; Miyanaga, R; Kato, S; Hayashi, Y; Sada, M; Fukuzawa, M; Kato, H; Takayama, T; Konishi, J; Matsushita, HO; Narasaka, T; Ohata, K; Togashi, K; Nakamura, H; Moriichi, K; Oda, Y; Kanda, N; Kuwai, T; Terai, S; Sanomura, M; Kitamura, S; Miyamoto, H; Kiriyama, S; Mizuno, C; Saito, Y; Sekine, S; Ito, S; Nakahira, H; Oka, S; Hayashi, Y; Yoshimura, K; Ishikawa, H; Matsuda, T

    JOURNAL OF GASTROENTEROLOGY   57 ( 8 )   547 - 558   2022年8月   ISSN:0944-1174 eISSN:1435-5922

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    記述言語:英語   出版者・発行元:Journal of Gastroenterology  

    Background: This is the first report from a multicenter prospective cohort study of colorectal neuroendocrine tumor (NET), the C-NET STUDY, conducted to assess the long-term outcomes of the enrolled patients. This report aimed to elucidate the clinicopathological features of the enrolled patients and lesions. Methods: Colorectal NET patients aged 20–74 years were consecutively enrolled and followed up at 50 institutions. The baseline characteristics and clinicopathological findings at enrollment and treatment were assessed. Results: A total of 495 patients with 500 colorectal NETs were included. The median patient age was 54 years, and 85.3% were asymptomatic. The most frequent lesion location was the lower rectum (88.0%); 99.4% of the lesions were clinically diagnosed to be devoid of metastatic findings, and 95.4% were treated with endoscopic resection. Lesions < 10 mm comprised 87.0% of the total, 96.6% had not invaded the muscularis propria, and 92.6% were classified as WHO NET grade 1. Positive lymphovascular involvement was found in 29.2% of the lesions. Its prevalence was high even in small NETs with immunohistochemical/special staining for pathological assessment (26.4% and 40.9% in lesions sized < 5 mm and 5–9 mm, respectively). Among 70 patients who underwent radical surgery primarily or secondarily, 18 showed positive lymph node metastasis. Conclusions: The characteristics of real-world colorectal NET patients and lesions are elucidated. The high positivity of lymphovascular involvement in small NETs highlights the necessity of assessing the clinical significance of positive lymphovascular involvement based on long-term outcomes, which will be examined in later stages of the C-NET STUDY. Trial registration number: UMIN000025215.

    DOI: 10.1007/s00535-022-01877-5

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  • High-risk HPV-related Squamous Cell Carcinoma in the Conjunctiva and Lacrimal sac: clinicopathologic Characteristics and Diagnostic Utility of p16 and Rb Immunohistochemistry. 査読 国際誌

    Hongo T, Yamamoto H, Tanabe M, Yasumatsu R, Kuga R, Miyazaki Y, Jiromaru R, Hashimoto K, Tateishi Y, Sonoda KH, Nakagawa T, Oda Y.

    Am J Surg Pathol.   46 ( 7 )   977 - 987   2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1097/PAS.0000000000001857.

  • An efficient procedure for the recovery of DNA from formalin-fixed paraffin-embedded tissue sections. 査読 国際誌

    Oba U, Kohashi K, Sangatsuda Y, Oda Y, Sonoda KH, Ohga S, Yoshimoto K, Arai Y, Yachida S, Shibata T, Ito T, Miura F.

    Biol Methods Protoc.   7 ( 1 )   bpac014   2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1093/biomethods/bpac014.

  • Cyclin-dependent kinase 8 is an independent prognosticator in uterine leiomyosarcoma. 査読 国際誌

    Yasutake N, Iwasaki T, Yamamoto H, Sonoda K, Kodama K, Okugawa K, Asanoma K, Yahata H, Kato K, Oda Y.

    Pathol Res Pract.   235   153920   2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.prp.2022.153920.

  • Palisading-like arrangement of immature ganglion cell in myenteric ganglia is a unique pathological feature of immaturity of ganglia. 査読 国際誌

    Yoshimaru K, Tamaki A, Matsuura T, Kohashi K, Kajihara K, Irie K, Hino Y, Uchida Y, Toriigahara Y, Kawano Y, Shirai T, Oda Y, Tajiri T, Taguchi T.

    J Pediatr Surg.   57 ( 7 )   1269 - 1273   2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.jpedsurg.2022.02.035.

  • A deep learning-based approach for the diagnosis of adrenal adenoma: A new trial using CT. 査読 国際誌

    Kusunoki M, Nakayama T, Nishie A, Yamashita Y, Kikuchi K, Eto M, Oda Y, Ishigami K.

    Br J Radiol.   95 ( 1135 )   20211066   2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1259/bjr.20211066.

  • High-risk HPV-related Squamous Cell Carcinoma in the Conjunctiva and Lacrimal sac Clinicopathologic Characteristics and Diagnostic Utility of p16 and Rb Immunohistochemistry

    Hongo, T; Yamamoto, H; Tanabe, M; Yasumatsu, R; Kuga, R; Miyazaki, Y; Jiromaru, R; Hashimoto, K; Tateishi, Y; Sonoda, KH; Nakagawa, T; Oda, Y

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY   46 ( 7 )   977 - 987   2022年7月   ISSN:0147-5185 eISSN:1532-0979

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    記述言語:英語   出版者・発行元:American Journal of Surgical Pathology  

    High-risk human papillomavirus (HPV) infection in conjunctival and lacrimal sac squamous cell carcinomas (SCCs) has been sporadically reported; however, its prevalence, clinicopathologic significance and surrogate markers have not been fully elucidated. Here, we attempted to clarify these questions in Japanese patients with conjunctiva and lacrimal sac SCCs. We retrospectively collected 51 conjunctival SCC and 7 lacrimal sac SCC samples and analyzed them for (1) transcriptionally active high-risk HPV infection using messenger RNA in situ hybridization and (2) protein expressions of p16 and Rb using immunohistochemistry (IHC). Among a total of 58 cases, 25 (43.1%) and 16 (27.6%) tumors were positive for p16-IHC and HPV in situ hybridization, respectively. Ten (19.6%) of the 51 conjunctival SCCs, especially in the palpebral conjunctiva, and 6 (85.7%) of the 7 lacrimal sac SCCs were positive for high-risk HPV. High-risk HPV infection was significantly associated with younger patients, nonkeratinizing SCC histology, p16-positivity and partial loss of Rb expression, but not with recurrence risk. Notably, p16-IHC was not a perfect surrogate marker for high-risk HPV infection; only 64% (16/25) of p16-positive tumors were positive for high-risk HPV. In contrast, the p16+/Rb partial loss pattern was exclusively correlated with high-risk HPV-positivity. The results suggest that the combination of p16 and Rb expression patterns by IHC could be a useful method to predict high-risk HPV infection in conjunctival and lacrimal sac SCCs. HPV infection may be of less prognostic value in this field of cancers.

    DOI: 10.1097/PAS.0000000000001857

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  • Approach for reclassification of collecting duct carcinoma and comparative histopathological analysis with SMARCB1/INI1-deficient renal cell carcinoma and fumarate hydratase-deficient renal cell carcinoma. 査読 国際誌

    Kiyozawa D, Kohashi K, Takamatsu D, Iwasaki T, Shibata D, Tomonaga T, Tateishi Y, Eto M, Kinjo M, Nishiyama K, Taguchi K, Oshiro Y, Kuboyama Y, Furuya M, Oda Y.

    Hum Pathol.   124   36 - 44   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.humpath.2022.03.002.

  • Prediction of pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma using 2-[ 18 F]-fluoro-2-deoxy-d-glucose positron-emission tomography. 査読 国際誌

    Tabata K, Nishie A, Shimomura Y, Isoda T, Kitamura Y, Nakata K, Yamada Y, Oda Y, Ishigami K, Baba S.

    Clin Radiol.   77 ( 6 )   436 - 442   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.crad.2022.03.001.

  • Impact of JMJD6 on intrahepatic cholangiocarcinoma. 査読 国際誌

    Kosai-Fujimoto Y, Itoh S, Yugawa K, Fukuhara T, Okuzaki D, Toshima T, Harada N, Oda Y, Yoshizumi T, Mori M.

    Mol Clin Oncol.   17 ( 2 )   131   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.3892/mco.2022.2564.

  • Histological background of dedifferentiated solitary fibrous tumour. 査読 国際誌

    Yamada Y, Kohashi K, Kinoshita I, Yamamoto H, Iwasaki T, Yoshimoto M, Ishihara S, Toda Y, Ito Y, Kuma Y, Yamada-Nozaki Y, Koga Y, Hashisako M, Kiyozawa D, Kitahara D, Narutomi F, Kuboyama Y, Nakamura T, Inoue T, Mukai M, Honda Y, Toyokawa G, Tsuchihashi K, Fushimi F, Taguchi K, Nishiyama K, Tamiya S, Oshiro Y, Furue M, Nakashima Y, Suzuki S, Iwaki T, Oda Y.

    J Clin Pathol.   75 ( 6 )   397 - 403   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1136/jclinpath-2020-207311.

  • Artificial intelligence for segmentation of bladder tumor cystoscopic images performed by U-Net with dilated convolution. 査読 国際誌

    Mutaguchi J, Morooka KI, Kobayashi S, Umehara A, Miyauchi S, Kinoshita F, Inokuchi J, Oda Y, Kurazume R, Eto M.

    J Endourol.   36 ( 6 )   827 - 834   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1089/end.2021.0483.

  • RNF43 as a predictor of malignant transformation of pancreatic mucinous cystic neoplasm. 査読 国際誌

    Sakihama K, Koga Y, Yamamoto T, Shimada Y, Yamada Y, Kawata J, Shindo K, Nakamura M, Oda Y.

    Virchows Arch.   480 ( 6 )   1189 - 1199   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00428-022-03277-9.

  • <i>RNF43</i> as a predictor of malignant transformation of pancreatic mucinous cystic neoplasm

    Sakihama, K; Koga, Y; Yamamoto, T; Shimada, Y; Yamada, Y; Kawata, J; Shindo, K; Nakamura, M; Oda, Y

    VIRCHOWS ARCHIV   480 ( 6 )   1189 - 1199   2022年6月   ISSN:0945-6317 eISSN:1432-2307

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    記述言語:英語   出版者・発行元:Virchows Archiv  

    Mucinous cystic neoplasm (MCN) of the pancreas rarely progresses to invasive carcinoma, but few studies have analyzed genomic alterations involved in its malignant transformation. The relationships of ring finger protein 43 (RNF43) mutations with cytological atypia, RNF43 protein expression, and Wnt signaling proteins in MCN remain unclear. This study included 106 MCN cases, classified into 89 low-grade dysplasia (LG), 9 high-grade dysplasia (HG), and 8 invasive carcinoma (INV). We analyzed HG/INV and LG lesions of 9 HG/INV cases and LG lesions of 9 LG cases using targeted sequencing and confirmed the protein expression of RNF43 and β-catenin. The frequency of RNF43 mutations was significantly higher in HG/INV cases than in LG cases. Furthermore, HG/INV lesions (56%) and LG lesions (33%) of HG/INV cases possessed RNF43 mutation, whereas no such mutation was detected in any LG cases. The expression of RNF43 was reduced in 71% of HG/INV cases and significantly correlated with histological grade and aberrant expression of β-catenin. In 3 of 5 RNF43-mutated cases, the expression of RNF43 was reduced, but there was no significant correlation between RNF43 mutation and protein expression. MCNs frequently harbored KRAS mutations, at rates of 100% in HG/INV lesions and 50% in LG lesions of HG/INV and LG cases. There was no significant difference in mutation frequency in LG lesions between HG/INV and LG cases. These results suggest that RNF43 mutations may be involved in and predictive of malignant transformation from an early stage of MCN.

    DOI: 10.1007/s00428-022-03277-9

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  • Prediction of pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma using 2-[<SUP>18</SUP>F]-fluoro-2-deoxy-D-glucose positron-emission tomography

    Tabata, K; Nishie, A; Shimomura, Y; Isoda, T; Kitamura, Y; Nakata, K; Yamada, Y; Oda, Y; Ishigami, K; Baba, S

    CLINICAL RADIOLOGY   77 ( 6 )   436 - 442   2022年6月   ISSN:0009-9260 eISSN:1365-229X

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    記述言語:英語   出版者・発行元:Clinical Radiology  

    AIM: To determine whether the pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma (PDAC) can be predicted using 2-[18F]-fluoro-2-deoxy-D-glucose positron-emission tomography (F-18 FDG-PET). MATERIALS AND METHODS: Twenty-eight patients with PDAC who underwent only neoadjuvant chemotherapy (NAC) before surgery were enrolled in the study. All patients had F-18 FDG-PET examinations before NAC. The resected specimen was pathologically evaluated according to the Classification of Pancreatic Carcinoma (7th edn). Patients were categorised into a non-response group and a response group based on the pathological findings. The non-response group (Grades 1a and 1b) showed ≤50% necrosis in the specimen, while the specimens of the response group (Grades 2–3) showed >50% necrosis. The maximum standardised uptake values (SUVmax) of the tumours on F-18 FDG-PET were measured. The mean values of SUVmax were compared between the two groups. The diagnostic performance of SUVmax in distinguishing the two groups was also evaluated using receiver operating characteristic analysis. RESULTS: The mean SUVmax of the response group was higher than that of the non-response group (9.00 ± 1.78 versus 4.26 ± 2.35; p<0.001). The optimal cut-off value of SUVmax was 9.28 for distinguishing the two groups. The sensitivity, specificity, and accuracy for the prediction in the response group were 80%, 95.7%, and 92.9%, respectively. CONCLUSIONS: SUVmax on F-18 FDG-PET may be useful as a biomarker to predict the pathological response to NAC in patients with PDAC.

    DOI: 10.1016/j.crad.2022.03.001

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  • Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: A possible association with TP53 mutation and loss of H3K27 trimethylation. 査読 国際誌

    Ishihara S, Yamamoto H, Iwasaki T, Toda Y, Yamamoto T, Yoshimoto M, Ito Y, Susuki Y, Kawaguchi K, Kinoshita I, Yamada Y, Kohashi K, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Kakuda Y, Nakashima Y, Oda Y.

    Mod Pathol.   35 ( 5 )   640 - 648   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41379-021-00972-x.

  • Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine. 査読 国際誌

    Tsukahara S, Shiota M, Takamatsu D, Nagakawa S, Matsumoto T, Kiyokoba R, Yagi M, Setoyama D, Noda N, Matsumoto S, Hayashi T, Contreras-Sanz A, Black PC, Inokuchi J, Kohashi K, Oda Y, Uchiumi T, Eto M, Kang D.

    Sci Rep.   12 ( 1 )   8535   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41598-022-12528-3.

  • Three-dimensional imaging of intramural perineural invasion in colorectal cancer: Three-dimensional reconstruction approach with multiple immunohistochemically stained sections. 査読 国際誌

    Miyashita Y, Ikeda T, Shinto E, Okano S, Korehisa S, Shimazaki H, Oki E, Ueno H, Oda Y, Mori M.

    Pathol Int.   72 ( 5 )   293 - 299   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/pin.13222.

  • Tumor progression by epithelial-mesenchymal transition in ARID1A- and SMARCA4-aberrant solid-type poorly differentiated gastric adenocarcinoma. 査読 国際誌

    Sasaki T, Kohashi K, Kawatoko S, Ihara E, Oki E, Nakamura M, Ogawa Y, Oda Y.

    Virchows Arch.   480 ( 5 )   1063 - 1075   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00428-021-03261-9.

  • Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma. 査読 国際誌

    Shimada E, Matsumoto Y, Nakagawa M, Susuki Y, Endo M, Setsu N, Fujiwara T, Iida K, Nabeshima A, Yahiro K, Kimura A, Hirose T, Kanahori M, Oyama R, Oda Y, Nakashima Y.

    Br J Cancer.   126 ( 9 )   1289 - 1300   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41416-021-01695-1.

  • Impact of nuclear factor erythroid 2-related factor 2 in hepatocellular carcinoma: Cancer metabolism and immune status. 査読 国際誌

    Iseda N, Itoh S, Yoshizumi T, Tomiyama T, Morinaga A, Yugawa K, Shimokawa M, Shimagaki T, Wang H, Kurihara T, Kitamura Y, Nagao Y, Toshima T, Harada N, Kohashi K, Baba S, Ishigami K, Oda Y, Mori M.

    Hepatol Commun.   6 ( 4 )   665 - 678   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1002/hep4.1838.

  • NECTIN4 expression in sebaceous and sweat gland carcinoma. 査読 国際誌

    Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Oda Y, Kaku-Ito Y.

    Eur J Dermatol.   32 ( 2 )   181 - 186   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1684/ejd.2022.4241.

  • Dental pulp stem cells as a therapy for congenital entero-neuropathy. 査読 国際誌

    Yoshimaru K, Yamaza T, Kajioka S, Sonoda S, Yanagi Y, Matsuura T, Yoshizumi J, Oda Y, Iwata N, Takai C, Nakayama S, Taguchi T.

    Sci Rep.   12 ( 1 )   6990   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41598-022-10077-3.

  • Clinical, radiological, and histopathological characteristics of periosteal chondrosarcoma with a focus on the frequency of medullary invasion. 査読 国際誌

    Nakagawa M, Endo M, Susuki Y, Yokoyama N, Maekawa A, Nabeshima A, Iida K, Fujiwara T, Setsu N, Matsunobu T, Matsumoto Y, Yokoyama R, Yamada Y, Kohashi K, Yamamoto H, Oda Y, Iwamoto Y, Nakashima Y.

    J Clin Med.   11 ( 7 )   2062   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.3390/jcm11072062.

  • One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: A real-world prospective study. 査読 国際誌

    Matsuno Y, Torisu T, Umeno J, Shibata H, Hirano A, Fuyuno Y, Okamoto Y, Fujioka S, Kawasaki K, Moriyama T, Nagasue T, Zeze K, Hirakawa Y, Kawatoko S, Koga Y, Oda Y, Esaki M, Kitazono T.

    Intest Res.   20 ( 2 )   260 - 268   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.5217/ir.2021.00124.

  • Myxoid type and non-myxoid type of intimal sarcoma in large vessels and heart: review of histological and genetic profiles of 20 cases. 査読 国際誌

    Yamada Y, Kinoshita I, Miyazaki Y, Tateishi Y, Kuboyama Y, Iwasaki T, Kohashi K, Yamamoto H, Ishihara S, Toda Y, Ito Y, Susuki Y, Kawaguchi K, Hashisako M, Yamada-Nozaki Y, Kiyozawa D, Mori T, Yamamoto T, Tsuchihashi K, Kuriwaki K, Mukai M, Kawai M, Suzuki K, Nishimura H, Bando K, Masumoto J, Fukushima M, Motoshita J, Mori H, Shiose A, Oda Y.

    Virchows Arch.   480 ( 4 )   919 - 925   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00428-022-03293-9.

  • Long-term follow up after sentinel node biopsy alone for early-stage cervical cancer. 査読 国際誌

    Yahata H, Kodama K, Okugawa K, Hachisuga K, Yasutake N, Maenohara S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Asanoma K, Kobayashi H, Sonoda K, Baba S, Ishigami K, Ohishi Y, Oda Y, Kato K.

    Gynecol Oncol.   165 ( 1 )   149 - 154   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.ygyno.2022.01.031.

  • An analysis of 20 cases of radiation-associated sarcoma, including 4 cases treated by carbon ion radiotherapy. 査読 国際誌

    Negishi T, Matsunobu A, Endo M, Yokoyama R, Kusano S, Furubayashi N, Taguchi K, Shioyama Y, Iida K, Fujiwara T, Setsu N, Matsumoto Y, Nakashima Y, Kohashi K, Yamamoto H, Oda Y, Nakamura M.

    Oncology.   100 ( 3 )   148 - 154   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1159/000521504.

  • Serum uric acid levels and nephrosclerosis in a population-based autopsy study: the hisayama study. 査読 国際誌

    Maki K, Hata J, Sakata S, Oishi E, Furuta Y, Nakano T, Oda Y, Kitazono T, Ninomiya T.

    Am J Nephrol.   53 ( 1 )   69 - 77   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1159/000521426.

  • Diagnostic utility of ERG immunostaining in dermatofibroma. 査読 国際誌

    Yamada Y, Ichiki T, Susuki Y, Yamada-Nozaki Y, Tateishi Y, Furue M, Oda Y.

    (Online ahead of print.) J Clin Pathol.   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1136/jclinpath-2022-208158.

  • Myeloid-derived suppressor cell infiltration is associated with a poor prognosis in patients with hepatocellular carcinoma. 査読 国際誌

    Tomiyama T, Itoh S, Iseda N, Toshida K, Morinaga A, Yugawa K, Fujimoto YK, Tomino T, Kurihara T, Nagao Y, Morita K, Harada N, Kohashi K, Oda Y, Mori M, Yoshizumi T.

    Oncol Lett.   23 ( 3 )   93   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.3892/ol.2022.13213.

  • Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma. 査読 国際誌

    Tanaka Y, Murata M, Tanegashima K, Oda Y, Ito T.

    Sci Rep.   12 ( 1 )   4031   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41598-022-07727-x.

  • Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses. 査読 国際誌

    Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M.

    J Exp Clin Cancer Res.   41 ( 1 )   89   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1186/s13046-022-02301-9.

  • IL-34 in hepatoblastoma cells potentially promote tumor progression via autocrine and paracrine mechanisms. 査読 国際誌

    Irie T, Yoshii D, Komohara Y, Fujiwara Y, Kadohisa M, Honda M, Suzu S, Matsuura T, Kohashi K, Oda Y, Hibi T.

    Cancer Med.   11 ( 6 )   1441 - 1453   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1002/cam4.4537.

  • Lymphoid and myeloid proliferative disorders associated with inflammatory bowel disease: a clinicopathological study of 15 cases. 査読 国際誌

    Hori Y, Yamamoto H, Kawatoko S, Nozaki Y, Torisu T, Kato K, Koga Y, Miyoshi H, Ohshima K, Tateishi Y, Nakamura S, Kitazono T, Oda Y.

    Hum Pathol.   120   88 - 98   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.humpath.2021.12.010.

  • Stratification of prostate cancer patients into low- and high-grade groups using multiparametric magnetic resonance radiomics with dynamic contrast-enhanced image joint histograms. 査読 国際誌

    Urakami A, Arimura H, Takayama Y, Kinoshita F, Ninomiya K, Imada K, Watanabe S, Nishie A, Oda Y, Ishigami K.

    Prostate.   82 ( 3 )   330 - 344   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1002/pros.24278.

  • Clinical impact of HSD3B1 polymorphism by metastatic volume and somatic HSD3B1 alterations in advanced prostate cancer. 査読 国際誌

    Shiota M, Fujimoto N, Sekino Y, Tsukahara S, Nagakawa S, Takamatsu D, Abe T, Kinoshita F, Ueda S, Ushijima M, Matsumoto T, Kashiwagi E, Inokuchi J, Uchiumi T, Oda Y, Eto M.

    Andrologia.   54 ( 1 )   e14307   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/and.14307.

  • Clinicopathological and histopathological review of dedifferentiated liposarcoma: a comprehensive study of 123 primary tumours. 査読 国際誌

    Mori T, Yamada Y, Kinoshita I, Kohashi K, Yamamoto H, Ito Y, Susuki Y, Kawaguchi K, Nakashima Y, Oda Y.

    Histopathology.   80 ( 3 )   538 - 557   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/his.14588.

  • Clinical impact of <i>HSD3B1</i> polymorphism by metastatic volume and somatic <i>HSD3B1</i> alterations in advanced prostate cancer

    Shiota, M; Fujimoto, N; Sekino, Y; Tsukahara, S; Nagakawa, S; Takamatsu, D; Abe, T; Kinoshita, F; Ueda, S; Ushijima, M; Matsumoto, T; Kashiwagi, E; Inokuchi, J; Uchiumi, T; Oda, Y; Eto, M

    ANDROLOGIA   54 ( 1 )   e14307   2022年2月   ISSN:0303-4569 eISSN:1439-0272

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    記述言語:英語   出版者・発行元:Andrologia  

    This study aimed to investigate the significance of HSD3B1 gene status including germline polymorphism and somatic alterations in prostate cancer. Patients with prostate cancer treated with androgen-deprivation therapy, as well as tissues from metastatic prostate cancer, were included. Genomic DNA was extracted from cancer tissues and whole blood samples, and HSD3B1 (rs1047303, 1245C) was genotyped by Sanger sequencing. The association of HSD3B1 genotype with progression-free survival according to metastatic volume was examined. Copy number alteration and gene expression of HSD3B1 were examined in prostate cancer cells and public datasets. Among 194 patients, 121 and 73 patients were categorized into low- and high-volume diseases respectively. In multivariate analysis, the adrenal-permissive genotype (AC/CC) was significantly associated with increased risk of progression compared with the adrenal-restrictive genotype (AA) in low volume, but not high-volume diseases. Somatic mutation in HSD3B1 was detected at least in two cases of castration-resistant prostate cancer tissues. HSD3B1 amplification and overexpression were detected in castration-resistant prostate cancer cells and tissues. The current findings suggest that both germline and somatic alterations of HSD3B1 may cooperatively promote castration resistance in prostate cancer and HSD3B1 as a promising biomarker for precision medicine, warranting further investigations.

    DOI: 10.1111/and.14307

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  • PD-L1/IDO1 expression and tumor-infiltrating lymphocyte (TIL) in solid type poorly differentiated gastric adenocarcinoma

    Kawatoko, S; Kohashi, K; Sasaki, T; Oda, Y

    CANCER SCIENCE   113   2022年2月   ISSN:1347-9032 eISSN:1349-7006

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  • HSD3B1 polymorphism and genomic HSD3B1 aberrations in prostate cancer

    Shiota, M; Fujimoto, N; Sekino, Y; Tsukahara, S; Nagakawa, S; Takamatsu, D; Abe, T; Kinoshita, F; Ueda, S; Matsumoto, T; Kashiwagi, E; Takeuchi, A; Inokuchi, J; Uchiumi, T; Oda, Y; Eto, M

    CANCER SCIENCE   113   1591 - 1591   2022年2月   ISSN:1347-9032 eISSN:1349-7006

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  • Comparative Evaluation of Plasma Metabolomic Data from Multiple Laboratories

    Nishiumi, S; Izumi, Y; Hirayama, A; Takahashi, M; Nakao, M; Hata, K; Saigusa, D; Hishinuma, E; Matsukawa, N; Tokuoka, SM; Kita, Y; Hamano, F; Okahashi, N; Ikeda, K; Nakanishi, H; Saito, K; Hirai, MY; Yoshida, M; Oda, Y; Matsuda, F; Bamba, T

    METABOLITES   12 ( 2 )   2022年2月   ISSN:2218-1989 eISSN:2218-1989

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    記述言語:英語   出版者・発行元:Metabolites  

    In mass spectrometry-based metabolomics, the differences in the analytical results from different laboratories/machines are an issue to be considered because various types of machines are used in each laboratory. Moreover, the analytical methods are unique to each laboratory. It is important to understand the reality of inter-laboratory differences in metabolomics. Therefore, we have evaluated whether the differences in analytical methods, with the exception sample pretreatment and including metabolite extraction, are involved in the inter-laboratory differences or not. In this study, nine facilities are evaluated for inter-laboratory comparisons of metabolomic analysis. Identical dried samples prepared from human and mouse plasma are distributed to each laboratory, and the metabolites are measured without the pretreatment that is unique to each laboratory. In these measurements, hydrophilic and hydrophobic metabolites are analyzed using 11 and 7 analytical methods, respectively. The metabolomic data acquired at each laboratory are integrated, and the differences in the metabolomic data from the laboratories are evaluated. No substantial difference in the relative quantitative data (human/mouse) for a little less than 50% of the detected metabolites is observed, and the hydrophilic metabolites have fewer differences between the laboratories compared with hydrophobic metabolites. From evaluating selected quantitatively guaranteed metabolites, the proportion of metabolites without the inter-laboratory differences is observed to be slightly high. It is difficult to resolve the inter-laboratory differences in metabolomics because all laboratories cannot prepare the same analytical environments. However, the results from this study indicate that the inter-laboratory differences in metabolomic data are due to measurement and data analysis rather than sample preparation, which will facilitate the understanding of the problems in metabolomics studies involving multiple laboratories.

    DOI: 10.3390/metabo12020135

    Web of Science

    Scopus

    PubMed

  • Clinicopathological and prognostic significance of TFE3 in papillary renal carcinoma (PRCC)

    Takamatsu, D; Kohashi, K; Kiyozawa, D; Takeuchi, A; Inokuchi, J; Eto, M; Oda, Y

    CANCER SCIENCE   113   1583 - 1583   2022年2月   ISSN:1347-9032 eISSN:1349-7006

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  • ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway. 査読 国際誌

    Guan W, Nakata K, Sagara A, Iwamoto C, Endo S, Matsuda R, Matsumoto S, Ikenaga N, Shindo K, Moriyama T, Onishi H, Ohuchida K, Oda Y, Nakamura M.

    Pancreatology.   22 ( 1 )   9 - 19   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.pan.2021.09.012.

  • The utility of core-needle tumor biopsy for pediatric patients. 査読 国際誌

    Kawakubo N, Takemoto J, Koga Y, Hino Y, Tamaki A, Kohashi K, Ono H, Oda Y, Ohga S, Tajiri T.

    Pediatr Int.   64 ( 1 )   e15228   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/ped.15228.

  • TROP2 expression in sebaceous and sweat gland carcinoma. 招待 査読 国際誌

    Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Ichiki T, Iwasaki T, Oda Y, Kaku-Ito Y.

    J Clin Med.   11 ( 3 )   607   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.3390/jcm11030607.

  • Standardization of evaluation method and prognostic significance of histological response to preoperative chemotherapy in high-grade non-round cell soft tissue sarcomas. 査読 国際誌

    Oda Y, Tanaka K, Hirose T, Hasegawa T, Hiruta N, Hisaoka M, Yoshimoto M, Otsuka H, Bekki H, Ishii T, Endo M, Kunisada T, Hiruma T, Tsuchiya H, Katagiri H, Matsumoto Y, Kawai A, Nakayama R, Kawashima H, Takenaka S, Emori M, Watanuki M, Yoshida Y, Okamoto T, Mizusawa J, Fukuda H, Ozaki T, Iwamoto Y, Nojima T.

    BMC Cancer.   22 ( 1 )   94   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1186/s12885-022-09195-y.

  • Merkel cell polyomavirus-negative Merkel cell carcinoma is associated with JAK-STAT and MEK-ERK pathway activation. 査読 国際誌

    Iwasaki T, Hayashi K, Matsushita M, Nonaka D, Kohashi K, Kuwamoto S, Umekita Y, Oda Y.

    Cancer Sci.   113 ( 1 )   251 - 260   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/cas.15187.

  • Evaluation of clinical significance of lymphovascular space invasion in stage IA endometrial cancer. 査読 国際誌

    Okugawa K, Yahata H, Hachisuga K, Tomonobe H, Yasutake N, Kodama K, Kenjo H, Yagi H, Ohgami T, Yasunaga M, Onoyama I, Asanoma K, Hori E, Ohishi Y, Oda Y, Kato K.

    Oncology.   100 ( 4 )   195 - 202   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1159/000521382.

  • The effects of ARID1A mutations on colorectal cancer and associations with PD-L1 expression by stromal cells. 査読 国際誌

    Kamori T, Oki E, Shimada Y, Hu Q, Hisamatsu Y, Ando K, Shimokawa M, Wakai T, Oda Y, Mori M.

    Cancer Rep (Hoboken).   5 ( 1 )   e1420   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1002/cnr2.1420.

  • Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults: The Hisayama study. 査読 国際誌

    32 ( 1 )   e13014   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/bpa.13014

  • Giant cranial angiolipoma with arteriovenous fistula: A case report

    Hatae R., Mizoguchi M., Arimura K., Kiyozawa D., Shimogawa T., Sangatsuda Y., Nishimura A., Ono K., Oda Y., Yoshimoto K.

    Surgical Neurology International   13   314   2022年   ISSN:2229-5097

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    記述言語:英語   出版者・発行元:Surgical Neurology International  

    Background: Angiolipomas are benign mesenchymal tumors comprising mature adipocytes and abnormal blood vessels, commonly found in the subcutaneous tissue of the trunk and rarely in the skull. Furthermore, sporadic cases of angiolipoma with arteriovenous fistula (AVF) have been reported. Case Description: We reported the case of a 72-year-old woman who presented with head swelling, seizures, and cognitive dysfunction. Computed tomography and magnetic resonance imaging revealed a right frontal bone tumor exceeding a sagittal suture of up to 10.7 cm. Angiography revealed AVF and varices formation. Endovascular embolization was performed to treat the AVF and reduce blood loss during surgical resection. Two days after the embolization, a craniotomy was performed; however, uncontrollable bleeding was observed at the time of tumor resection. Postoperatively, the patient was symptom-free and has been stable for 2 years without recurrence. Conclusion: Despite careful preoperative evaluation and treatment planning, the patient in this case report was difficult to treat. Such cases require adequate preparation.

    DOI: 10.25259/SNI_422_2022

    Scopus

    PubMed

  • Clinicopathological and prognostic significance of H3K27 methylation status in malignant peripheral nerve sheath tumor: correlation with skeletal muscle differentiation. 査読 国際誌

    Ito Y, Kohashi K, Endo M, Yoshimoto M, Ishihara S, Toda Y, Susuki Y, Kawaguchi K, Furukawa H, Tateishi Y, Yamada Y, Kinoshita I, Mori T, Yamamoto H, Nakashima Y, Oda Y.

    Virchows Arch.   479 ( 6 )   1233 - 1244   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00428-021-03189-0.

  • Prognostic implication of desmoplastic stroma in synovial sarcoma: a histological review. 査読 国際誌

    Toda Y, Yamada Y, Kohashi K, Ishihara S, Ito Y, Susuki Y, Kawaguchi K, Kinoshita I, Kiyozawa D, Mori T, Kuboyama Y, Tateishi Y, Yamamoto H, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Mawatari M, Oda Y.

    Pathol Res Pract.   ( 228 )   153668   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • PD-L1 expression, tumor-infiltrating lymphocytes, mismatch repair deficiency, EGFR alteration and HPV infection in sinonasal squamous cell carcinoma. 査読 国際誌

    Hongo T, Yamamoto H, Jiromaru R, Yasumatsu R, Kuga R, Nozaki Y, Hashimoto K, Matsuo M, Wakasaki T, Tamae A, Taguchi K, Toh S, Masuda M, Nakagawa T, Oda Y.

    Mod Pathol.   34 ( 11 )   1966 - 1978   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41379-021-00868-w.

  • Prognostic impact of Vessels that Encapsulate Tumor Cluster (VETC) in patients who underwent liver transplantation for hepatocellular carcinoma. 査読 国際誌

    Kawasaki J, Toshima T, Yoshizumi T, Itoh S, Mano Y, Wang H, Iseda N, Harada N, Oda Y, Mori M.

    Ann Surg Oncol.   28 ( 13 )   8186 - 8195   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1245/s10434-021-10209-5.

  • Endometrial endometrioid carcinoma, G1, is more aggressive in the elderly than in the young. 査読 国際誌

    Hachisuga K, Ohishi Y, Tomonobe H, Yahata H, Kato K, Oda Y.

    Histopathology.   79 ( 5 )   708 - 719   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/his.14400.

  • Biliary atresia-specific deciduous pulp stem cells feature biliary deficiency. 査読 国際誌

    Sonoda S, Yoshimaru K, Yamaza H, Yuniartha R, Matsuura T, Yamauchi-Tomoda E, Murata S, Nishida K, Oda Y, Ohga S, Tajiri T, Taguchi T, Yamaza T.

    Stem Cell Res Ther.   12 ( 1 )   582   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1186/s13287-021-02652-8.

    リポジトリ公開URL: https://hdl.handle.net/2324/7172586

  • The Japanese Society of Pathology Practical Guidelines on the handling of pathological tissue samples for cancer genomic medicine. 査読 国際誌

    Hatanaka Y, Kuwata T, Morii E, Kanai Y, Ichikawa H, Kubo T, Hatanaka KC, Sakai K, Nishio K, Fujii S, Okamoto W, Yoshino T, Ochiai A, Oda Y.

    Pathol Int.   71 ( 11 )   725 - 740   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/pin.13170.

  • PD-L1 expression, tumor-infiltrating lymphocytes, mismatch repair deficiency, EGFR alteration and HPV infection in sinonasal squamous cell carcinoma. 査読 国際誌

    Hongo T, Yamamoto H, Jiromaru R, Yasumatsu R, Kuga R, Nozaki Y, Hashimoto K, Matsuo M, Wakasaki T, Tamae A, Taguchi K, Toh S, Masuda M, Nakagawa T, Oda Y.

    Mod Pathol.   34 ( 11 )   1966 - 1978   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41379-021-00868-w.

  • Tumor microenvironment in giant cell tumor of bone: evaluation of PD-L1 expression and SIRPα infiltration after denosumab treatment. 査読 国際誌

    11 ( 1 )   14821   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41598-021-94022-w.

  • Does the use of peripheral immune‐related markers indicate whether to administer pazopanib, trabectedin, or eribulin to advanced soft tissue sarcoma patients? 査読 国際誌

    10 ( 21 )   4972   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Lymphocyte-C-reactive protein ratio as a prognostic marker associated with the tumor immune microenvironment in intrahepatic cholangiocarcinoma. 査読 国際誌

    Yugawa K, Itoh S, Yoshizumi T, Morinaga A, Iseda N, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.

    Int J Clin Oncol.   26 ( 10 )   1901 - 1910   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s10147-021-01962-4.

  • Lymphocyte-to-C-reactive protein ratio as a prognostic factor for hepatocellular carcinoma. 査読 国際誌

    Iseda N, Itoh S, Yoshizumi T, Tomiyama T, Morinaga A, Shimagaki T, Wang H, Kurihara T, Toshima T, Nagao Y, Harada N, Oda Y, Mori M.

    Int J Clin Oncol.   26 ( 10 )   1890 - 1900   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s10147-021-01985-x.

  • Pathological review of cardiac amyloidosis using autopsy cases in a single Japanese institution. 査読 国際誌

    Tateishi Y, Yamada Y, Katsuki M, Nagata T, Yamamoto H, Kohashi K, Koga Y, Hashisako M, Kiyozawa D, Mori T, Kuboyama Y, Kakinokizono A, Miyazaki Y, Yamaguchi A, Tsutsui H, Ninomiya T, Naiki H, Oda Y.

    Pathol Res Pract.   227   153635   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.prp.2021.153635.

  • Pathologic diabetic nephropathy in autopsied diabetic cases with normoalbuminuria from a japanese community-based study. 査読 国際誌

    Sasaki T, Nakagawa K, Hata J, Hirakawa Y, Shibata M, Nakano T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T.

    Kidney Int Rep.   6 ( 12 )   3035 - 3044   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.ekir.2021.09.007.

  • Serum NT-proBNP levels and histopathological myocardial fibrosis in autopsied cases from a Japanese community: The Hisayama Study. 査読 国際誌

    Sasaki T, Izumaru K, Hata J, Sakata S, Oishi E, Nagata T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T.

    J Cardiol.   78 ( 3 )   237 - 243   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.jjcc.2021.03.014.

  • Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. 査読 国際誌

    Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP.

    Cell.   184 ( 18 )   4753 - 4771   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.cell.2021.07.020.

  • Expression of CD44 variant 9 induces chemoresistance of gastric cancer by controlling intracellular reactive oxygen spices accumulation. 査読 国際誌

    Jogo T, Oki E, Nakanishi R, Ando K, Nakashima Y, Kimura Y, Saeki H, Oda Y, Maehara Y, Mori M.

    Gastric Cancer.   24 ( 5 )   1089 - 1099   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s10120-021-01194-5.

  • Identification of SLC38A7 as a prognostic marker and potential therapeutic target of lung squamous cell carcinoma. 査読 国際誌

    Haratake N, Hu Q, Okamoto T, Jogo T, Toyokawa G, Kinoshita F, Takenaka T, Tagawa T, Iseda N, Itoh S, Yamada Y, Oda Y, Shimokawa M, Kikutake C, Suyama M, Unoki M, Sasaki H, Mori M.

    Ann Surg.   274 ( 3 )   500 - 507   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1097/SLA.0000000000005001

  • Prognostic implications of the coexisting precursor lesion types in invasive gallbladder cancer. 査読 国際誌

    Mochidome N, Koga Y, Ohishi Y, Miyazaki T, Matsuda R, Yamada Y, Aishima S, Nakamura M, Oda Y.

    Hum Pathol.   114   44 - 53   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.humpath.2021.05.001.

  • Clinical significance of signal regulatory protein alpha (SIRPα) expression in esophageal squamous cell carcinoma. 査読 国際誌

    112 ( 8 )   3018 - 3028   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/cas.14971.

  • Quantification of HER family dimers by proximity ligation assay and its clinical evaluation in non-small cell lung cancer patients treated with osimertinib. 査読 国際誌

    Liu R, Ota K, Iwama E, Yoneshima Y, Tanaka K, Inoue H, Tagawa T, Oda Y, Mori M, Nakanishi Y, Okamoto I.

    Lung Cancer.   158   156 - 161   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.lungcan.2021.05.023.

  • Effect of the 2013 ASCO-CAP HER2 testing guideline on the management of IHC/HER2 2+ invasive breast cancer. 査読 国際誌

    Yamada M, Kubo M, Yamamoto H, Yamashita N, Kai M, Zaguirre K, Kaneshiro K, Shimazaki A, Hayashi S, Kawaji H, Mori M, Oda Y, Nakamura M.

    Anticancer Res.   41 ( 8 )   4143 - 4149   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.21873/anticanres.15217.

  • Genetic and transcriptomic analyses in a rare case of HPV-related oropharyngeal squamous cell carcinoma combined with small cell carcinoma. 査読 国際誌

    Sato K, Nishiyama K, Taguchi K, Jiromaru R, Yamamoto H, Matsunaga A, Nagata R, Rikimaru F, Toh S, Higaki Y, Oda S, Nakagawa T, Masuda M.

    Cold Spring Harb Mol Case Stud.   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1101/mcs.a006102.

  • The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma. 査読 国際誌

    Ishihara S, Iwasaki T, Kohashi K, Yamada Y, Toda Y, Ito Y, Susuki Y, Kawaguchi K, Takamatsu D, Kawatoko S, Kiyozawa D, Mori T, Kinoshita I, Yamamoto H, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Oda Y.

    J Cancer Res Clin Oncol.   147 ( 7 )   2003 - 2011   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1007/s00432-021-03616-4.

  • Trop2 expression in extramammary paget’s disease and normal skin. 査読 国際誌

    22 ( 14 )   7706   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.3390/ijms22147706.

  • CDK4: a novel therapeutic target for extramammary paget's disease. 査読 国際誌

    Hashimoto H, Kaku-Ito Y, Oda Y, Ito T.

    Front Oncol.   11   710378   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.3389/fonc.2021.710378.

  • Morphological, immunohistochemical, and genomic analyses of papillary renal neoplasm with reverse polarity. 査読 国際誌

    Kiyozawa D, Kohashi K, Takamatsu D, Yamamoto T, Eto M, Iwasaki T, Motoshita J, Shimokama T, Kinjo M, Oshiro Y, Yonemasu H, Oda Y.

    Hum Pathol.   112   48 - 58   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.humpath.2021.03.009.

  • Neoantigens elicit T cell responses in breast cancer. 査読 国際誌

    Morisaki T, Kubo M, Umebayashi M, Yew PY, Yoshimura S, Park JH, Kiyotani K, Kai M, Yamada M, Oda Y, Nakamura Y, Morisaki T, Nakamura M.

    Sci Rep.   11 ( 1 )   13590   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1038/s41598-021-91358-1.

  • Brachyury expression in intracranial SMARCB1-deficient tumors: important points for distinguishing poorly differentiated chordoma from atypical teratoid/rhabdoid tumor. 査読 国際誌

    Kohashi K, Yamamoto H, Yamada Y, Kinoshita I, Oda Y.

    Hum Pathol.   112   1 - 8   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.humpath.2021.03.001.

  • Cytolytic activity score as a biomarker for antitumor immunity and clinical outcome in patients with gastric cancer. 査読 国際誌

    Hu Q, Nonaka K, Wakiyama H, Miyashita Y, Fujimoto Y, Jogo T, Hokonohara K, Nakanishi R, Hisamatsu Y, Ando K, Kimura Y, Masuda T, Oki E, Mimori K, Oda Y, Mori M.

    Cancer Med.   10 ( 9 )   3129 - 3138   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1002/cam4.3828.

  • Myxoepithelioid tumor with chordoid feature: A clinicopathological, immunohistochemical, and genetic study of 14 cases of SMARCB1/INI1-deficient soft-tissue neoplasm. 査読 国際誌

    Kinoshita I, Kohashi K, Yamamoto H, Yamada Y, Inoue T, Higaki K, Teramoto N, Oshiro Y, Nakashima Y, Oda Y.

    Histopathology.   79 ( 4 )   629 - 641   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/his.14393.

  • Salivary duct carcinoma with rhabdoid features-no or aberrant expression of e-cadherin and genetic changes in CDH1: Immunohistochemical and genetic analyses of 17 cases. 査読 国際誌

    Kusafuka K, Yamada H, Ishino K, Maeda M, Yamanegi K, Baba S, Ohuchi T, Inagaki H, Yamamoto H, Iwasaki T, Tsuchiya C, Sugimura H, Suzuki M.

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  • ARID1A deficiency is associated with high programmed death ligand 1 expression in hepatocellular carcinoma. 査読 国際誌

    Iseda N, Itoh S, Yoshizumi T, Yugawa K, Morinaga A, Tomiyama T, Toshima T, Kohashi K, Oda Y, Mori M.

    Hepatol Commun.   5 ( 4 )   675 - 688   2021年4月

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  • Prognostic impact of tumor microvessels in intrahepatic cholangiocarcinoma: association with tumor-infiltrating lymphocytes. 査読 国際誌

    Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.

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  • Association of PD-L1 and IDO1 expression with JAK-STAT pathway activation in soft-tissue leiomyosarcoma. 査読 国際誌

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    Itoh S, Yoshizumi T, Kitamura Y, Yugawa K, Iseda N, Shimagaki T, Nagao Y, Toshima T, Harada N, Kohashi K, Baba S, Ishigami K, Oda Y, Mori M.

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  • Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status. 査読 国際誌

    Yugawa K, Itoh S, Iseda N, Kurihara T, Kitamura Y, Toshima T, Harada N, Kohashi K, Baba S, Ishigami K, Oda Y, Yoshizumi T, Mori M.

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  • Nectin cell adhesion molecule 4 (NECTIN4) expression in cutaneous squamous cell carcinoma: A new therapeutic target? 査読 国際誌

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  • Immunogenic characteristics of microsatellite instability-low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses. 査読 国際誌

    Imamura Y, Toihata T, Haraguchi I, Ogata Y, Takamatsu M, Kuchiba A, Tanaka N, Gotoh O, Mori S, Nakashima Y, Oki E, Mori M, Oda Y, Taguchi K, Yamamoto M, Morita M, Yoshida N, Baba H, Mine S, Nunobe S, Sano T, Noda T, Watanabe M.

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  • The forkhead box M1 (FOXM1) expression and antitumor effect of FOXM1 inhibition in malignant rhabdoid tumor. 査読 国際誌

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  • Histological categorization of the desmoplastic reaction is a predictor of patient prognosis in oesophageal squamous cell carcinoma. 査読 国際誌

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  • CMTM6 stabilizes PD-L1 expression and is a new prognostic impact factor in hepatocellular carcinoma. 査読 国際誌

    Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.

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  • Clinicopathologic significance of EGFR mutation and HPV infection in sinonasal squamous cell carcinoma.  査読 国際誌

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  • Impact of capicua on pancreatic cancer progression. 査読 国際誌

    Yoshiya S, Itoh S, Yoshizumi T, Yugawa K, Kurihara T, Toshima T, Harada N, Hashisako M, Yonemasu H, Fukuzawa K, Oda Y, Mori M.

    Ann Surg Oncol. Online ahead of print.   2021年1月

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  • Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma. 査読 国際誌

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    Genes Chromosomes Cancer.   60 ( 1 )   26 - 37   2021年1月

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  • Genomic sequencing of cancer-related genes in sinonasal squamous cell carcinoma and coexisting inverted papilloma. 招待 査読 国際誌

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  • Pathological evaluation of tumor grade for salivary adenoid cystic carcinoma: A proposal of an objective grading system. 査読 国際誌

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  • Comprehensive molecular profiling broadens treatment options for breast cancer patients. 査読 国際誌

    Kawaji H, Kubo M, Yamashita N, Yamamoto H, Kai M, Kajihara A, Yamada M, Kurata K, Kaneshiro K, Harada Y, Hayashi S, Shimazaki A, Mori H, Akiyoshi S, Oki E, Oda Y, Baba E, Mori M, Nakamura M.

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  • Validity of the prognostication tool PREDICT version 2.2 in Japanese breast cancer patients. 査読 国際誌

    Zaguirre K, Kai M, Kubo M, Yamada M, Kurata K, Kawaji H, Kaneshiro K, Harada Y, Hayashi S, Shimazaki A, Morisaki T, Mori H, Oda Y, Chen S, Moriyama T, Shimizu S, Nakamura M.

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  • Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells. 査読 国際誌

    Yuniartha R, Yamaza T, Sonoda S, Yoshimaru K, Matsuura T, Yamaza H, Oda Y, Ohga S, Taguchi T.

    Stem Cell Res Ther.   12 ( 1 )   57   2021年1月

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  • Reevaluation of Concurrent AChE and HE staining for Hirschsprung's disease. 査読 国際誌

    Yoshimaru K, Matsuura T, Yanagi Y, Obata S, Takahashi Y, Kajihara K, Ohmori A, Irie K, Hino Y, Shibui Y, Tamaki A, Kohashi K, Oda Y, Taguchi T.

    Pediatr Int. 2021 Jan   2021年1月

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  • Gene amplification of YB-1 in castration-resistant prostate cancer in association with aberrant androgen receptor expression. 査読 国際誌

    Shiota M, Sekino Y, Tsukahara S, Abe T, Kinoshita F, Imada K, Ueda S, Ushijima M, Nagakawa S, Matsumoto T, Kashiwagi E, Takeuchi A, Inokuchi J, Uchiumi T, Oda Y, Eto M.

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  • Interleukin-38 promotes tumor growth through regulation of CD8 + tumor-infiltrating lymphocytes in lung cancer tumor microenvironment. 査読 国際誌

    Kinoshita F, Tagawa T, Akamine T, Takada K, Yamada Y, Oku Y, Kosai K, Ono Y, Tanaka K, Wakasu S, Oba T, Osoegawa A, Shimokawa M, Oda Y, Hoshino T, Mori M.

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  • The clinical and histopathological features of cutaneous immune-related adverse events and their outcomes. 査読 国際誌

    Hashimoto H, Ito T, Ichiki T, Yamada Y, Oda Y, Furue M.

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  • p16 Overexpression and Rb Loss Correlate with High-risk HPV Infection in Oropharyngeal Squamous Cell Carcinoma. 査読 国際誌

    Jiromaru R, Yamamoto H, Yasumatsu R, Hongo T, Nozaki Y, Nakano T, Hashimoto K, Nakagawa T, Oda Y.

    Histopathology.   2021年1月

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  • PD‑L1 and IDO‑1 expression in undifferentiated pleomorphic sarcoma: The associations with tumor infiltrating lymphocytes, dMMR and HLA class I. 査読 国際誌

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  • Chronic inflammatory changes and oxidative stress in the background of "pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm". 査読 国際誌

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  • Impact of DNA integrity on the success rate of tissue-based next-generation sequencing: lessons from nationwide cancer genome screening project SCRUM-Japan GI-SCREEN. 査読 国際誌

    Kuwata T, Wakabayashi M, Hatanaka Y, Morii E, @Oda Y, Taguchi K, Noguchi M, Ishikawa Y, Nakajima T, Sekine S, Nomura S, Okamoto W, Fujii S, Yoshino T; SCRUM-Japan GI-SCREEN Pathology Group.

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  • Autocrine leukemia inhibitory factor promotes esophageal squamous cell carcinoma progression via Src family kinase-dependent Yes-associated protein activation. 査読 国際誌

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  • Frequent MN1 gene mutations in malignant peripheral nerve sheath tumor. 査読 国際誌

    Kinoshita I, Yamada Y, Kohashi K, Yamamoto H, Iwasaki T, Ishihara S, Toda YU, Ito Y, Susuki Y, Kawaguchi K, Ichiki T, Sato Y, Furue M, Nakashima Y, Oda Y.

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  • CMTM6 stabilizes PD-L1 expression and is a new prognostic impact factor in hepatocellular carcinoma. 査読 国際誌

    Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.

    Hepatol Commun. 2020 Nov   5 ( 2 )   334 - 348   2020年11月

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  • Congenital biliary dilatation in the era of laparoscopic surgery, focusing on the high incidence of anatomical variations of the right hepatic artery. 査読 国際誌

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  • Clinical significance of preoperative inflammatory markers in non-small cell lung cancer patients: A multicenter retrospective study. 査読 国際誌

    Takada K, Takamori S, Matsubara T, Haratake N, Akamine T, Kinoshita F, Ono Y, Wakasu S, Tanaka K, Oku Y, Oba T, Osoegawa A, Tagawa T, Takenoyama M, Shimokawa M, Oda Y, Mori M.

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  • Quantitative evaluation of liver function and pathology with hepatocyte fraction on Gadoxetic acid-enhanced MR imaging. 査読 国際誌

    Fujita N, Nishie A, Asayama Y, Ishigami K, Ushijima Y, Kakihara D, Takayama Y, Yoshizumi T, Hida T, Oda Y, Okuaki T, Honda H.

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  • The SWI/SNF chromatin-remodeling complex status in renal cell carcinomas with sarcomatoid or rhabdoid features. 査読 国際誌

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  • LINE-1 hypomethylation is associated with malignant traits and cell proliferation in lung adenocarcinoma. 査読 国際誌

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  • Clinicopathological features and immunohistochemical utility of NTRK, ALK and ROS1-rearranged papillary thyroid carcinomas and anaplastic thyroid carcinomas. 査読 国際誌

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  • Prognostic impact of 8-hydroxy-deoxyguanosine and its repair enzyme 8-hydroxy-deoxyguanosine DNA glycosylase in hepatocellular carcinoma. 査読 国際誌

    Pathol Int.   70 ( 8 )   533 - 541   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/pin.12952.

  • Programmed death ligand 1/indoleamine 2,3-dioxygenase 1 expression and tumor-infiltrating lymphocyte status in renal cell carcinoma with sarcomatoid changes and rhabdoid features. 査読 国際誌

    Kiyozawa D, Takamatsu D, Kohashi K, Kinoshita F, Ishihara S, Toda Y, Eto M, Oda Y.

    Hum Pathol.   101   31 - 39   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.humpath.2020.04.003.

  • Association of pretransplant BK Polyomavirus antibody status with BK Polyomavirus infection after kidney transplantation: A prospective cohort pilot study of 47 transplant recipients. 査読 国際誌

    Hisadome Y, Noguchi H, Nakafusa Y, Sakihama K, Mei T, Kaku K, Okabe Y, Masutani K, Ohara Y, Ikeda K, Oda Y, Nakamura M.

    Transplant Proc.   52 ( 6 )   1762 - 1768   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1016/j.transproceed.2020.01.164.

  • Combined Evaluation of Tumor-Infiltrating CD8 + and FoxP3 + Lymphocytes Provides Accurate Prognosis in Stage IA Lung Adenocarcinoma.

    2020年6月

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    記述言語:英語  

  • Genetic landscape of external auditory canal squamous cell carcinoma. 査読 国際誌

    Sato K, Komune N, Hongo T, Koike K, Niida A, Uchi R, Noda T, Kogo R, Matsumoto N, Yamamoto H, Masuda M, Oda Y, Mimori K, Nakagawa T.

    Cancer Sci.   111 ( 8 )   3010 - 3019   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/cas.14515.

  • Activation of the Akt/mammalian target of rapamycin pathway in combined hepatocellular carcinoma and cholangiocarcinoma significant correlation between p-4E-BP1 expression in cholangiocarcinoma component and prognosis 査読

    Yukihiko Okumura, Kenichi Kohashi, Yuki Tanaka, Masaki Kato, Yoshihiko Maehara, Yoshihiro Ogawa, Yoshinao Oda

    Virchows Archiv   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00428-019-02741-3

  • Quantitative evaluation of the intratumoral distribution of platinum in oxaliplatin-treated rectal cancer: In situ visualization of platinum via synchrotron radiation X-ray fluorescence spectrometry.

    Koba R, Fujita H, Nishibori M, Saeki K, Nagayoshi K, Sadakari Y, Nagai S, Sekizawa O, Nitta K, Manabe T, Ueki T, Ishida T, Oda Y, Nakamura M.

    Int J Cancer.   2020年5月

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    記述言語:英語  

  • Clinical impact of skeletal muscle area in patients with non-small cell lung cancer treated with anti-PD-1 inhibitors 査読

    Kazuki Takada, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto, Mototsugu Shimokawa, Sho Wakasu, Shinkichi Takamori, Gouji Toyokawa, Taro Oba, Atsushi Osoegawa, Tetsuzo Tagawa, Yoshinao Oda, Yoichi Nakanishi, Masaki Mori

    Journal of Cancer Research and Clinical Oncology   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00432-020-03146-5

  • Is remnant pancreatic cancer after pancreatic resection more frequent in early-stage pancreatic cancer than in advancedstage cancer? 査読 国際誌

    Ann Gastroenterol Surg.   4 ( 4 )   448 - 454   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: DOI: 10.1002/ags3.12340

  • Concomitant Intraductal Papillary Mucinous Neoplasm in Pancreatic Ductal Adenocarcinoma Is an Independent Predictive Factor for the Occurrence of New Cancer in the Remnant Pancreas. 査読 国際誌

    Matsuda R, Miyasaka Y, Ohishi Y, Yamamoto T, Saeki K, Mochidome N, Abe A, Ozono K, Shindo K, Ohtsuka T, Kikutake C, Nakamura M, Oda Y.

    Ann Surg.   271 ( 5 )   941 - 948   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi:10.1097/SLA.0000000000003060

  • PD-L1 and IDO1 expression and tumor-infiltrating lymphocytes in osteosarcoma patients comparative study of primary and metastatic lesions 査読

    Yu Toda, Kenichi Kohashi, Yuichi Yamada, Masato Yoshimoto, Shin Ishihara, Yoshihiro Ito, Takeshi Iwasaki, Hidetaka Yamamoto, Yoshihiro Matsumoto, Yasuharu Nakashima, Masaaki Mawatari, Yoshinao Oda

    Journal of Cancer Research and Clinical Oncology   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00432-020-03242-6

  • Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype 査読

    Kazuki Takada, Gouji Toyokawa, Fumihiko Kinoshita, Tomoko Jogo, Kenichi Kohashi, Sho Wakasu, Yuki Ono, Kensuke Tanaka, Taro Oba, Atsushi Osoegawa, Tetsuzo Tagawa, Koichi Azuma, Isamu Okamoto, Mototsugu Shimokawa, Yoshinao Oda, Masaki Mori

    Journal of Cancer Research and Clinical Oncology   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00432-020-03250-6

  • Quantification of intratumoral collagen and elastin fibers within hepatocellular carcinoma tissues finds correlations with clinico-patho-radiological features 査読

    Junki Maehara, Yohei Masugi, Tokiya Abe, Hanako Tsujikawa, Yutaka Kurebayashi, Akihisa Ueno, Hidenori Ojima, Shigeo Okuda, Masahiro Jinzaki, Masahiro Shinoda, Yuko Kitagawa, Yoshinao Oda, Hiroshi Honda, Michiie Sakamoto

    Hepatology Research   50 ( 5 )   607 - 619   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/hepr.13484

  • OX40 and LAG3 are associated with better prognosis in advanced gastric cancer patients treated with anti-programmed death-1 antibody 査読

    Hirofumi Ohmura, Kyoko Yamaguchi, Fumiyasu Hanamura, Mamoru Ito, Akitaka Makiyama, Keita Uchino, Hozumi Shimokawa, Shingo Tamura, Taito Esaki, Kenji Mitsugi, Yoshihiro Shibata, Hisanobu Oda, Kenji Tsuchihashi, Hiroshi Ariyama, Hitoshi Kusaba, Yoshinao Oda, Koichi Akashi, Eishi Baba

    British journal of cancer   122 ( 10 )   1507 - 1517   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41416-020-0810-1

  • Activation of TLR4 signaling inhibits progression of osteosarcoma by stimulating CD8-positive cytotoxic lymphocytes 査読

    Kenichiro Yahiro, Yoshihiro Matsumoto, Hisakata Yamada, Makoto Endo, Nokitaka Setsu, Toshifumi Fujiwara, Makoto Nakagawa, Atsushi Kimura, Eijiro Shimada, Seiji Okada, Yoshinao Oda, Yasuharu Nakashima

    Cancer Immunology, Immunotherapy   69 ( 5 )   745 - 758   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00262-020-02508-9

  • Serum markers associated with treatment response and survival in non-small cell lung cancer patients treated with anti-PD-1 therapy 査読

    Kazuki Takada, Shinkichi Takamori, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto, Mototsugu Shimokawa, Taro Oba, Atsushi Osoegawa, Tetsuzo Tagawa, Mitsuhiro Takenoyama, Yoshinao Oda, Yoichi Nakanishi, Masaki Mori

    Lung Cancer   145   18 - 26   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.lungcan.2020.04.034

  • Microsatellite instability in Japanese female patients with triple-negative breast cancer 査読

    Kanako Kurata, Makoto Kubo, Masaya Kai, Hitomi Mori, Hitomi Kawaji, Kazuhisa Kaneshiro, Mai Yamada, Reiki Nishimura, Tomofumi Osako, Nobuyuki Arima, Masayuki Okido, Yoshinao Oda, Masafumi Nakamura

    Breast Cancer   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s12282-019-01043-5

  • Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10-year experience of a single institute.

    Kodama K, Sonoda K, Kijima M, Yamaguchi S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Yahata H, Ohishi Y, Oda Y, Kato K.

    Asia Pac J Clin Oncol.   2020年4月

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    記述言語:英語  

  • Re-evaluation of preoperative endometrial smears for the cytodiagnosis of uterine leiomyosarcoma. 査読 国際誌

    Sonoda K, Nogami M, Kodama K, Oda Y, Kato K.

    Eur J Gynaecol Oncol.   41 ( 2 )   167 - 170   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Retroperitoneal Myxofibrosarcoma A Controversial Entity 査読

    Masato Yoshimoto, Yuichi Yamada, Shin Ishihara, Kenichi Kohashi, Yu Toda, Yoshihiro Ito, Yosuke Susuki, Izumi Kinoshita, Hidetaka Yamamoto, Yasuharu Nakashima, Yoshinao Oda

    Pathology Research and Practice   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.prp.2020.152969

  • Natural history and clinical outcomes of pancreatic neuroendocrine neoplasms based on the WHO 2017 classification; a single-center experience of 30 years 査読

    Nao Fujimori, Masami Miki, Lingaku Lee, Kazuhide Matsumoto, Yu Takamatsu, Takehiro Takaoka, Katsuhito Teramatsu, Yuta Suehiro, Masatoshi Murakami, Hisato Igarashi, Takamasa Oono, Takao Ohtsuka, Masafumi Nakamura, Yutaka Koga, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa

    Pancreatology   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.pan.2020.04.003

  • High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities 査読

    Youran Zou, Gulisa Turashvili, Robert A. Soslow, Kay J. Park, Sabrina Croce, W. Glenn McCluggage, Colin J.R. Stewart, Yoshinao Oda, Esther Oliva, Robert H. Young, Arnaud Da Cruz Paula, Kimberly Dessources, Charles W. Ashley, Martee L. Hensley, Stephen Yip, Britta Weigelt, Ryma Benayed, Cristina R. Antonescu, Cheng Han Lee, Sarah Chiang

    Modern Pathology   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41379-020-0535-y

  • Diagnostic utility of pan-Trk immunohistochemistry for inflammatory myofibroblastic tumours 査読

    Hidetaka Yamamoto, Yui Nozaki, Kenichi Kohashi, Izumi Kinoshita, Yoshinao Oda

    Histopathology   76 ( 5 )   774 - 778   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/his.14010

  • HPV-related Sinonasal Carcinoma: Clinicopathologic Features, Diagnostic Utility of p16 and Rb Immunohistochemistry, and EGFR Copy Number Alteration.

    Jiromaru R, Yamamoto H, Yasumatsu R, Hongo T, Nozaki Y, Hashimoto K, Taguchi K, Masuda M, Nakagawa T, Oda Y.

    Am J Surg Pathol.   2020年3月

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    記述言語:英語  

  • Immunohistochemical BRAF V600E Expression and Intratumor BRAF V600E Heterogeneity in Acral Melanoma: Implication in Melanoma-Specific Survival. 査読 国際誌

    Ito T, Kaku-Ito Y, Murata M, Furue K, Shen C, Oda Y, Furue M.

    J Clin Med.   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • A model study for the manufacture and validation of clinical-grade deciduous dental pulp stem cells for chronic liver fibrosis treatment 査読

    Tsuyoshi Iwanaka, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Shouichi Ohga, Yoshinao Oda, Tomoaki Taguchi

    Stem Cell Research and Therapy   11 ( 1 )   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s13287-020-01630-w

  • Solid-type poorly differentiated adenocarcinoma of the stomach Deficiency of mismatch repair and SWI/SNF complex 査読

    Shinichi Tsuruta, Kenichi Kohashi, Yuichi Yamada, Minako Fujiwara, Yutaka Koga, Eikichi Ihara, Yoshihiro Ogawa, Eiji Oki, Masafumi Nakamura, Yoshinao Oda

    Cancer Science   111 ( 3 )   1008 - 1019   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/cas.14301

  • Sclerosing epithelioid mesenchymal neoplasm of the pancreas - a proposed new entity.

    Mod Pathol.   2020年3月

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    記述言語:英語  

  • Colorectal diffuse large B-cell lymphoma: molecular subclassification and prognostic significance of immunoglobulin gene translocation.

    Hori Y, Yamamoto H, Nozaki Y, Torisu T, Fujiwara M, Taguchi K, Nishiyama K, Nakamura S, Kitazono T, Oda Y.

    Hum Pathol.   2020年2月

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    記述言語:英語  

  • Establishment and characterization of a novel primitive yolk sac tumour cell line, TC587. 査読 国際誌

    Iwasaki T, Kohashi K, Ohno M, Taguchi T, Oda Y.

    Anticancer Res.   40 ( 2 )   759 - 766   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Impact of Immune Response on Outcomes in Hepatocellular Carcinoma: Association With Vascular Formation. 査読 国際誌

    Itoh S, Yoshizumi T, Yugawa K, Imai D, Yoshiya S, Takeishi K, Toshima T, Harada N, Ikegami T, Soejima Y, Kohashi K, Oda Y, Mori M.

    Hepatology.   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Helper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancer 査読

    Kyoko Yamaguchi, Mamoru Ito, Hirofumi Ohmura, Fumiyasu Hanamura, Michitaka Nakano, Kenji Tsuchihashi, Shuntaro Nagai, Hiroshi Ariyama, Hitoshi Kusaba, Hidetaka Yamamoto, Yoshinao Oda, Masafumi Nakamura, Koichi Akashi, Eishi Baba

    OncoImmunology   9 ( 1 )   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/2162402X.2020.1724763

  • Association of glucose tolerance status with pancreatic β- and α-cell mass in community-based autopsy samples of Japanese individuals The Hisayama Study 査読

    2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aims/Introduction: Changes in histologically quantified β- and α-cell mass during the development of glucose intolerance have not been fully elucidated. The aim of the present study was to explore differences in β- and α-cell mass according to the glucose tolerance status. Materials and Methods: Autopsy samples from a total of 103 individuals (40 with normal glucose tolerance, 31 with prediabetes and 32 with type 2 diabetes mellitus) who underwent a 75-g oral glucose tolerance test within 5 years before death were selected from 643 community-based autopsy samples collected from 2002 to 2016. Fractional β-cell area (BCA) and α-cell area were quantified with Image Pro Plus software. Associations of BCA and α-cell area with glucose tolerance status were assessed using a linear regression analysis, and Spearman’s correlation coefficients between glycemic markers and β-cell function were estimated. Results: The mean values of BCA decreased significantly with worsening glucose tolerance status (mean ± standard error 1.85 ± 0.10% in normal glucose tolerance, 1.59 ± 0.11% in prediabetes and 1.17 ± 0.11% in type 2 diabetes mellitus, P for trend < 0.001), whereas there was no significant association between α-cell area and glucose tolerance status. BCA was inversely correlated with fasting and 2-h plasma glucose levels during oral glucose tolerance test and glycated hemoglobin measurement, and positively correlated with disposition index (all P < 0.01). Conclusions: β-Cell mass decreased significantly with worsening glucose tolerance, from the stage of prediabetes, in the Japanese population. Prevention of declining β-cell mass before the onset of glucose intolerance is important to reduce the burden of type 2 diabetes mellitus.

    DOI: 10.1111/jdi.13232

  • FAM115C could be a novel tumor suppressor associated with prolonged survival in pancreatic cancer patients 査読

    Kiyoshi Saeki, Hideya Onishi, Satoko Koga, Shu Ichimiya, Kazunori Nakayama, Yasuhiro Oyama, Makoto Kawamoto, Kukiko Sakihama, Takeo Yamamoto, Ryota Matsuda, Yoshihiro Miyasaka, Masafumi Nakamura, Yoshinao Oda

    Journal of Cancer   11 ( 8 )   2289 - 2302   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.7150/jca.38399

  • Automated approach for estimation of grade groups for prostate cancer based on histological image feature analysis 査読

    Alamgir Hossain, Hidetaka Arimura, Fumio Kinoshita, Kenta Ninomiya, Sumiko Watanabe, Kenjiro Imada, Ryoma Koyanagi, Yoshinao Oda

    Prostate   80 ( 3 )   291 - 302   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/pros.23943

  • Comparative Study of Myxofibrosarcoma With Undifferentiated Pleomorphic Sarcoma: Histopathologic and Clinicopathologic Review.

    Yoshimoto M, Yamada Y, Ishihara S, Kohashi K, Toda Y, Ito Y, Yamamoto H, Furue M, Nakashima Y, Oda Y.

    2020年1月

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    記述言語:英語  

  • Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5 査読

    Yohei Ando, Kenoki Ohuchida, Yoshiki Otsubo, Shin Kibe, Shin Takesue, Toshiya Abe, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Yoshinao Oda, Masafumi Nakamura

    PloS one   15 ( 1 )   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0228015

  • Survival and ocular preservation in a long-term cohort of Japanese patients with retinoblastoma 査読

    Tamaki Ueda, Yuhki Koga, Hiroshi Yoshikawa, Mika Tanabe, Kanako Yamana, Utako Oba, Kentaro Nakashima, Hiroaki Ono, Takuya Ichimura, Shunji Hasegawa, Wakako Kato, Tetsuko Kobayashi, Hideki Nakayama, Yasunari Sakai, Tadamasa Yoshitake, Saiji Ohga, Yoshinao Oda, Shigenobu Suzuki, Koh Hei Sonoda, Shouichi Ohga

    BMC Pediatrics   20 ( 1 )   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s12887-020-1923-7

  • Methylation of drug resistance-related genes in chemotherapy-sensitive Epstein-Barr virus-associated gastric cancer.

    Ohmura H, Ito M, Uchino K, Okada C, Tanishima S, Yamada Y, Momosaki S, Komoda M, Kuwayama M, Yamaguchi K, Okumura Y, Nakano M, Tsuchihashi K, Isobe T, Ariyama H, Kusaba H, Oda Y, Akashi K, Baba E.

    FEBS Open Bio.   2020年1月

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    記述言語:英語  

  • Non-transmissible MV Vector with Segmented RNA Genome Establishes Different Types of iPSCs from Hematopoietic Cells.

    Hiramoto T, Tahara M, Liao J, Soda Y, Miura Y, Kurita R, Hamana H, Inoue K, Kohara H, Miyamoto S, Hijikata Y, Okano S, Yamaguchi Y, Oda Y, Ichiyanagi K, Toh H, Sasaki H, Kishi H, Ryo A, Muraguchi A, Takeda M, Tani K.

    Mol Ther.   2020年1月

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    記述言語:英語  

  • Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations 査読

    Yusuke Tsuda, Makoto Hirata, Kotoe Katayama, Toru Motoi, Daisuke Matsubara, Yoshinao Oda, Masashi Fujita, Hiroshi Kobayashi, Hirotaka Kawano, Yoshihiro Nishida, Tomohisa Sakai, Tomotake Okuma, Takahiro Goto, Koichi Ogura, Akira Kawai, Keisuke Ae, Ukei Anazawa, Yoshiyuki Suehara, Shintaro Iwata, Satoru Miyano, Seiya Imoto, Tatsuhiro Shibata, Hidewaki Nakagawa, Rui Yamaguchi, Sakae Tanaka, Koichi Matsuda

    International Journal of Cancer   145 ( 12 )   3276 - 3284   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ijc.32421

  • Spread through air spaces in lung neuroendocrine tumor 査読

    Yuka Kozuma, Gouji Toyokawa, Yuichi Yamada, Fumihiro Shoji, Koji Yamazaki, Yoshinao Oda, Sadanori Takeo

    Translational Lung Cancer Research   8   S439 - S442   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21037/tlcr.2019.10.20

  • Uptake of 18F-FDG in Adrenal Adenomas Is Associated With Unenhanced CT Value and Constituent Cells 査読

    Ryo Murayama, Akihiro Nishie, Tomoyuki Hida, Shingo Baba, Junichi Inokuchi, Yoshinao Oda, Hiroshi Honda

    Clinical nuclear medicine   44 ( 12 )   943 - 948   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/RLU.0000000000002759

  • Intra-and inter-tumor braf heterogeneity in acral melanoma An immunohistochemical analysis 査読

    Takamichi Ito, Yumiko Kaku-Ito, Maho Murata, Toshio Ichiki, Yuki Kuma, Yuka Tanaka, Taketoshi Ide, Fumitaka Ohno, Maiko Wada-Ohno, Yuichi Yamada, Yoshinao Oda, Masutaka Furue

    International journal of molecular sciences   20 ( 24 )   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms20246191

  • The balance of forces generated by kinesins controls spindle polarity and chromosomal heterogeneity in tetraploid cells.

    Shu S, Iimori M, Wakasa T, Ando K, Saeki H, Oda Y, Oki E, Maehara Y

    J Cell Sci.   2019年12月

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    記述言語:日本語  

  • Integrated exome and RNA sequencing of dedifferentiated liposarcoma.

    Hirata M, Asano N, Katayama K, Yoshida A, Tsuda Y, Sekimizu M, Mitani S, Kobayashi E, Komiyama M, Fujimoto H, Goto T, Iwamoto Y, Naka N, Iwata S, Nishida Y, Hiruma T, Hiraga H, Kawano H, Motoi T, Oda Y, Matsubara D, Fujita M, Shibata T, Nakagawa H, Nakayama R, Kondo T, Imoto S, Miyano S, Kawai A, Yamaguchi R, Ichikawa H, Matsuda K.

    Nat Commun   2019年12月

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    記述言語:日本語  

  • The Altered Mucosal Barrier Function in the Duodenum Plays a Role in the Pathogenesis of Functional Dyspepsia. 査読 国際誌

    Komori K, Ihara E, Minoda Y, Ogino H, Sasaki T, Fujiwara M, Oda Y, Ogawa Y.

    Dig Dis Sci.   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Detection of Hepatitis Virus B And C in Archival Autopsy Specimens of Liver Cirrhosis. 査読 国際誌

    Tsutsumi Y, Shiogama K, Teramoto H, Aishima S, Oda Y, Ohashi R, Ajioka Y, Naito M.

    Biomed J Sci &Tech Res.   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma. 査読 国際誌

    Mano Y, Yoshio S, Shoji H, Tomonari S, Aoki Y, Aoyanagi N, Okamoto T, Matsuura Y, Osawa Y, Kimura K, Yugawa K, Wang H, Oda Y, Yoshizumi T, Maehara Y, Kanto T.

    J Gastroenterol.   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Clinicopathological review of solitary fibrous tumors dedifferentiation is a major cause of patient death 査読

    Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Itou, Yutaka Koga, Mikiko Hashisako, Yui Nozaki, Daisuke Kiyozawa, Daichi Kitahara, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Yoshifumi Matsushita, Fumiyoshi Fushimi, Kenichi Taguchi, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda

    Virchows Archiv   475 ( 4 )   467 - 477   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00428-019-02622-9

  • Reduced Estimated GFR and Cardiac Remodeling A Population-Based Autopsy Study 査読

    Kensuke Izumaru, Jun Hata, Toshiaki Nakano, Yutaka Nakashima, Masaharu Nagata, Masayo Fukuhara, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya

    American Journal of Kidney Diseases   74 ( 3 )   373 - 381   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1053/j.ajkd.2019.02.013

  • 18F-FDG uptake in PET/CT is a potential predictive biomarker of response to anti-PD-1 antibody therapy in non-small cell lung cancer.

    Takada K, Toyokawa G, Yoneshima Y, Tanaka K, Okamoto I, Shimokawa M, Wakasu S, Haro A, Osoegawa A, Tagawa T, Oda Y, Nakanishi Y, Mori M.

    Sci Rep.   2019年9月

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    記述言語:日本語  

  • Spread through air spaces in non-small cell lung cancer.

    Kozuma Y, Toyokawa G, Yamada Y, Shoji F, Yamazaki K, Oda Y, Takeo S

    2019年9月

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    記述言語:日本語  

  • IFN-γ Promotes Epithelial-Mesenchymal Transition and the Expression of PD-L1 in Pancreatic Cancer 査読

    240   115 - 123   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Tumor immune reactions not only provide host defense but also accelerate tumor immune escape and phenotype switching. Here, we examined the association of programmed cell death ligand 1 (PD-L1) expression with epithelial-mesenchymal transition (EMT)–associated markers in pancreatic ductal adenocarcinoma (PDA) within the context of the tumor microenvironment. Materials and methods: PDA samples from 36 patients were analyzed for PD-L1, vimentin, E-cadherin, and Snail expressions and for PDA cell and immune cell infiltration. PD-L1 expression and EMT in PDA cell lines under conditions of altering interferon gamma (IFN-γ) signals were also assessed. Results: Immunohistochemistry revealed a significant correlation between vimentin and PD-L1 expression, whereas double staining showed them to be simultaneously expressed by PDA cells. Positive vimentin expression was associated with the infiltration of a lower number of CD8 + T cells and a higher number of FoxP3 + cells and poor patient prognosis (P = 0.03). PDA tumor cells promoted PD-L1 expression and EMT under the presence of IFN-γ which was inhibited by the signal transducer and activator of transcription (STAT)1 small interfering RNA. Conclusions: Strong correlations were observed between PD-L1 expression, EMT, and the immunosuppressive tumor microenvironment. Targeting STAT1 combined with PD-1/PD-L1 immunotherapy may improve outcomes for patients with PDA.

    DOI: 10.1016/j.jss.2019.02.038

  • T-bet+ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer 査読

    Hitomi Mori, Makoto Kubo, Masaya Kai, Mai Yamada, Kanako Kurata, Hitomi Kawaji, Kazuhisa Kaneshiro, Tomofumi Osako, Reiki Nishimura, Nobuyuki Arima, Masayuki Okido, Junji Kishimoto, Yoshinao Oda, Masafumi Nakamura

    Breast Cancer Research and Treatment   176 ( 3 )   569 - 577   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10549-019-05256-2

  • Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body 査読

    Xiaopeng Bai, Eikichi Ihara, Yoshihihro Otsuka, Shinichi Tsuruta, Katsuya Hirano, Yoshimasa Tanaka, Haruei Ogino, Mayumi Hirano, Takatoshi Chinen, Hirotada Akiho, Kazuhiko Nakamura, Yoshinao Oda, Yoshihiro Ogawa

    European Journal of Pharmacology   857   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ejphar.2019.172405

  • CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors 査読

    Masami Miki, Takamasa Oono, Nao Fujimori, Takehiro Takaoka, Ken Kawabe, Yoshihiro Miyasaka, Takao Ohtsuka, Daisuke Saito, Masafumi Nakamura, Yasuyuki Ohkawa, Yoshinao Oda, Mikita Suyama, Tetsuhide Ito, Yoshihiro Ogawa

    Cancer Medicine   8 ( 8 )   3748 - 3760   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/cam4.2232

  • Mucosal incision assisted biopsy vs. endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions: A randomized crossover study. 査読 国際誌

    Osoegawa T, Minoda Y, Ihara E, Komori K, Aso A, Goto A, Itaba S, Ogino H, Nakamura K, Harada N, Makihara K, Tsuruta S, Yamamoto H, Ogawa Y.

    Dig Endosc.   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma. 査読 国際誌

    Nakamura S, Sadakari Y, Ohtsuka T, Okayama T, Nakashima Y, Gotoh Y, Saeki K, Mori Y, Nakata K, Miyasaka Y, Onishi H, Oda Y, Goggins M, Nakamura M.

    Ann Surg Oncol.   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot.

    Yamamura K, Sakamoto I, Morihana E, Hirata Y, Nagata H, Yamasaki Y, Okumura Y, Kohashi K, Koto K, Tsutsui H, Ohga S.

    Int J Cardiol.   2019年7月

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    記述言語:日本語  

  • A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma 査読

    Taichi Matsubara, Kazuki Takada, Koichi Azuma, Shinkichi Takamori, Gouji Toyokawa, Akira Haro, Atsushi Osoegawa, Tetsuzo Tagawa, Akihiko Kawahara, Jun Akiba, Isamu Okamoto, Yoichi Nakanishi, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara

    Annals of Surgical Oncology   26 ( 6 )   1925 - 1933   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-019-07257-3

  • Clinicopathological features and phenotypic classification of de novo-type colorectal carcinomas differ from those of colorectal carcinomas derived from flat adenomas.

    Koga Y, Hirahashi M, Ohishi Y, Oda Y.

    Pathol Int.   2019年6月

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    記述言語:その他  

  • Gastric hepatoid adenocarcinomas are a genetically heterogenous group; most tumors show chromosomal instability, but MSI tumors do exist 査読

    Shinichi Tsuruta, Yoshihiro Ohishi, Minako Fujiwara, Eikichi Ihara, Yoshihiro Ogawa, Eiji Oki, Masafumi Nakamura, Yoshinao Oda

    Human Pathology   88   27 - 38   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2019.03.006

  • Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma 査読

    Kazuki Takada, Mototsugu Shimokawa, Kensuke Tanaka, Kenichi Kohashi, Akira Haro, Atsushi Osoegawa, Tetsuzo Tagawa, Koichi Azuma, Isamu Okamoto, Yoshinao Oda, Masaki Mori

    PloS one   14 ( 6 )   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0217991

  • CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis 査読

    Zilong Yan, Kenoki Ohuchida, Biao Zheng, Takashi Okumura, Shin Takesue, Hiromichi Nakayama, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura

    Journal of Cancer Research and Clinical Oncology   145 ( 5 )   1147 - 1164   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00432-019-02860-z

  • The Significance of CD44 Variant 9 in Resected Lung Adenocarcinoma Correlation with Pathological Early-Stage and EGFR Mutation 査読

    Takaki Akamine, Tetsuzo Tagawa, Kayo Ijichi, Gouji Toyokawa, Shinkichi Takamori, Fumihiko Hirai, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Annals of Surgical Oncology   26 ( 5 )   1544 - 1551   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-018-07137-2

  • Navigation surgery using indocyanine green fluorescent imaging for hepatoblastoma patients 査読

    Ryota Souzaki, Naonori Kawakubo, Toshiharu Matsuura, Koichiro Yoshimaru, Yuhki Koga, Junkichi Takemoto, Yuichi Shibui, Kenichi Kohashi, Makoto Hayashida, Yoshinao Oda, Shouichi Ohga, Tomoaki Taguchi

    Pediatric surgery international   35 ( 5 )   551 - 557   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00383-019-04458-5

  • Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens 査読

    Shinji Kohsaka, Kenji Tatsuno, Toshihide Ueno, Masaaki Nagano, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Daiya Takai, Masachika Ikegami, Hiroshi Kobayashi, Hidenori Kage, Mizuo Ando, Keisuke Hata, Hiroki Ueda, Shogo Yamamoto, Shinya Kojima, Kumiko Oseto, Keisuke Akaike, Yoshiyuki Suehara, Takuo Hayashi, Tsuyoshi Saito, Fumiyuki Takahashi, Kazuhisa Takahashi, Kazuya Takamochi, Kenji Suzuki, Satoshi Nagayama, Yoshinao Oda, Koshi Mimori, Soichiro Ishihara, Yutaka Yatomi, Takahide Nagase, Jun Nakajima, Sakae Tanaka, Masashi Fukayama, Katsutoshi Oda, Masaomi Nangaku, Kohei Miyazono, Kiyoshi Miyagawa, Hiroyuki Aburatani, Hiroyuki Mano

    Cancer Science   110 ( 4 )   1464 - 1479   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/cas.13968

  • Genetic assessment of recurrent pancreatic high-risk lesions in the remnant pancreas Metachronous multifocal lesion or local recurrence? 査読

    Yoshitaka Gotoh, Takao Ohtsuka, So Nakamura, Koji Shindo, Kenoki Ohuchida, Yoshihiro Miyasaka, Yasuhisa Mori, Naoki Mochidome, Yoshinao Oda, Masafumi Nakamura

    Surgery (United States)   165 ( 4 )   767 - 774   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.surg.2018.10.025

  • Highly expressed EZH2 in combination with BAP1 and MTAP loss, as detected by immunohistochemistry, is useful for differentiating malignant pleural mesothelioma from reactive mesothelial hyperplasia 査読

    Masayo Yoshimura, Yoshiaki Kinoshita, Makoto Hamasaki, Shinji Matsumoto, Tomoyuki Hida, Yoshinao Oda, Akinori Iwasaki, Kazuki Nabeshima

    Lung Cancer   130   187 - 193   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.lungcan.2019.02.004

  • Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix 査読

    Takashi Okumura, Kenoki Ouchida, Shin Kibe, Chika Iwamoto, Yohei Ando, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Masafumi Sada, Kohei Horioka, Naoki Mochidome, Makoto Arita, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Ohtsuka Takao, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura

    International Journal of Cancer   144 ( 6 )   1401 - 1413   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ijc.31775

  • A novel prognostic marker in patients with non-small cell lung cancer: musculo-immuno-nutritional score calculated by controlling nutritional status and creatine kinase. 査読 国際誌

    Takamori S, Toyokawa G, Shimokawa M, Kinoshita F, Kozuma Y, Matsubara T, Haratake N, Akamine T, Hirai F, Tagawa T, Oda Y, Maehara Y.

    J Thorac Dis.   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Positive correlation between the density of macrophages and T-cells in undifferentiated sarcoma. 査読 国際誌

    Komohara Y, Takeya H, Wakigami N, Kusada N, Bekki H, Ishihara S, Takeya M, Nakashima Y, Oda Y.

    Med Mol Morphol.   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Wnt/β-catenin signaling, which is activated in odontomas, reduces Sema3A expression to regulate odontogenic epithelial cell proliferation and tooth germ development 査読

    9 ( 1 )   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Odontomas, developmental anomalies of tooth germ, frequently occur in familial adenomatous polyposis patients with activated Wnt/β-catenin signaling. However, roles of Wnt/β-catenin signaling in odontomas or odontogenic cells are unclear. Herein, we investigated β-catenin expression in odontomas and functions of Wnt/β-catenin signaling in tooth germ development. β-catenin frequently accumulated in nucleus and/or cellular cytoplasm of odontogenic epithelial cells in human odontoma specimens, immunohistochemically. Wnt/β-catenin signaling inhibited odontogenic epithelial cell proliferation in both cell line and tooth germ development, while inducing immature epithelial bud formation. We identified Semaphorin 3A (Sema3A) as a downstream molecule of Wnt/β-catenin signaling and showed that Wnt/β-catenin signaling-dependent reduction of Sema3A expression resulted in suppressed odontogenic epithelial cell proliferation. Sema3A expression is required in appropriate epithelial budding morphogenesis. These results suggest that Wnt/β-catenin signaling negatively regulates odontogenic epithelial cell proliferation and tooth germ development through decreased-Sema3A expression, and aberrant activation of Wnt/β-catenin signaling may associate with odontoma formation.

    DOI: 10.1038/s41598-019-39686-1

  • Short- and long-term outcomes of surgical treatment for remnant gastric cancer after distal gastrectomy 査読

    Yu Nakaji, Hiroshi Saeki, Kensuke Kudou, Ryota Nakanishi, Masahiko Sugiyama, Yuichiro Nakashima, Kouji Andou, Yoshinao Oda, Eiji Oki, Yoshihiko Maehara

    Anticancer research   39 ( 3 )   1411 - 1415   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.13256

  • Posttransplant recipient-derived CD4 + T-cell lymphoproliferative disease in X-linked hyper-IgM syndrome 査読

    Yasuaki Hagio, Akira Shiraishi, masataka ishimura, Motoshi Sonoda, Katsuhide Eguchi, Hidetaka Yamamoto, Yoshinao Oda, Shoichi Ohga

    Pediatric Blood and Cancer   66 ( 3 )   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/pbc.27529

  • HuC/D expression in small round cell tumors and neuroendocrine tumors a useful tool for distinguishing neuroblastoma from childhood small round cell tumors 査読

    Junkichi Takemoto, Masaaki Kuda, Kenichi Kouhashi, Yuichi Yamada, Yutaka Koga, Izumi Kinoshita, Ryota Sozaki, Tomoaki Taguchi, Yoshinao Oda

    Human Pathology   85   162 - 167   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2018.11.004

  • Glypican-3 expression in malignant small round cell tumors 査読

    Yuichi Shibui, Kina Miyoshi, Kenichi Kouhashi, Yoshiaki Kinoshita, Masaaki Kuda, Hidetaka Yamamoto, Tomoaki Taguchi, Yoshinao Oda

    Oncology Letters   17 ( 3 )   3523 - 3528   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3892/ol.2019.9976

  • Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion 査読

    Shin Kibe, Kenoki Ouchida, Yohei Ando, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Takashi Okumura, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Masaya Shimamoto, Ohtsuka Takao, Kazuhiro Mizumoto, Yoshinao Oda, Masafumi Nakamura

    Cancer Letters   444   70 - 81   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.canlet.2018.12.005

  • A Positive Correlation Between the EZH2 and PD-L1 Expression in Resected Lung Adenocarcinomas 査読

    Gouji Toyokawa, Kazuki Takada, Tetsuzo Tagawa, Ryuji Hamamoto, Yuichi Yamada, Mototsugu Shimokawa, Yoshinao Oda, Yoshihiko Maehara

    Annals of Thoracic Surgery   107 ( 2 )   393 - 400   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.athoracsur.2018.08.056

  • Acquired isolated hypoganglionosis as a distinct entity: results from a nationwide survey. 査読 国際誌

    Obata S, Yoshimaru K, Kirino K, Izaki T, Ieiri S, Yamataka A, Koshinaga T, Iwai J,Ikeda H, Matsufuji H, Oda Y, Taguchi T.

    Pediatr Surg Int.   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Co-expression of IDO1 and PD-L1 in lung squamous cell carcinoma Potential targets of novel combination therapy 査読

    Kazuki Takada, Kenichi Kouhashi, Mototsugu Shimokawa, Akira Haro, Atsushi Osoegawa, Tetsuzo Tagawa, Takashi Seto, Yoshinao Oda, Yoshihiko Maehara

    Lung Cancer   128   26 - 32   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.lungcan.2018.12.008

  • Neoadjuvant Chemotherapy with Gemcitabine Plus Nab-Paclitaxel for Borderline Resectable Pancreatic Cancer Potentially Improves Survival and Facilitates Surgery 査読

    Yoshihiro Miyasaka, Ohtsuka Takao, Ryuichiro Kimura, Ryota Matsuda, Yasuhisa Mori, Kohei Nakata, Daisuke Kakihara, Nao Fujimori, Takamasa Ohno, Yoshinao Oda, Masafumi Nakamura

    Annals of Surgical Oncology   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-019-07309-8

  • Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors. 査読 国際誌

    Nakashima Y, Ohtsuka T, Nakamura S, Mori Y, Nakata K, Miyasaka Y, Ishigami K, Matsuda R, Oda Y, Nakamura M.

    Pancreatology.   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Sclerosing epithelioid mesenchymal neoplasm of the pancreas – a proposed new entity 査読

    Olca Basturk, Britta Weigelt, Volkan Adsay, Jamal K. Benhamida, Gokce Askan, Lu Wang, Maria E. Arcila, Giuseppe Zamboni, Noriyoshi Fukushima, Rodrigo Gularte-Mérida, Arnaud Da Cruz Paula, Pier Selenica, Rahul Kumar, Fresia Pareja, Christopher A. Maher, John Scholes, Yoshinao Oda, Donatella Santini, Leona A. Doyle, Iver Petersen, Uta Flucke, Christian Koelsche, Samuel J. Reynolds, Aslihan Yavas, Andreas von Deimling, Jorge S. Reis-Filho, David S. Klimstra

    2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We have encountered pancreatic tumors with unique histologic features, which do not conform to any of the known tumors of the pancreas or other anatomical sites. We aimed to define their clinicopathologic features and whether they are characterized by recurrent molecular signatures. Eight cases were identified; studied histologically and by immunohistochemistry. Selected cases were also subjected to whole-exome sequencing (WES; n = 4), RNA-sequencing (n = 6), Archer FusionPlex assay (n = 5), methylation profiling using the Illumina MethylationEPIC (850k) array platform (n = 6), and TERT promoter sequencing (n = 5). Six neoplasms occurred in females. The mean age was 43 years (range: 26–75). Five occurred in the head/neck of the pancreas. All patients were treated surgically; none received neoadjuvant/adjuvant therapy. All patients are free of disease after 53 months of median follow-up (range: 8–94). The tumors were well-circumscribed, and the median size was 1.8 cm (range: 1.3–5.8). Microscopically, the unencapsulated tumors had a geographic pattern of epithelioid cell nests alternating with spindle cell fascicles. Some areas showed dense fibrosis, in which enmeshed tumor cells imparted a slit-like pattern. The predominant epithelioid cells had scant cytoplasm and round-oval nuclei with open chromatin. The spindle cells displayed irregular, hyperchromatic nuclei. Mitoses were rare. No lymph node metastases were identified. All tumors were positive for vimentin, CD99 and cytokeratin (patchy), while negative for markers of solid pseudopapillary neoplasm, neuroendocrine, acinar, myogenic/rhabdoid, vascular, melanocytic, or lymphoid differentiation, gastrointestinal stromal tumor as well as MUC4. Whole-exome sequencing revealed no recurrent somatic mutations or amplifications/homozygous deletions in any known oncogenes or tumor suppressor genes. RNA-sequencing and the Archer FusionPlex assay did not detect any recurrent likely pathogenic gene fusions. Single sample gene set enrichment analysis revealed that these tumors display a likely mesenchymal transcriptomic program. Unsupervised analysis (t-SNE) of their methylation profiles against a set of different mesenchymal neoplasms demonstrated a distinct methylation pattern. Here, we describe pancreatic neoplasms with unique morphologic/immunophenotypic features and a distinct methylation pattern, along with a lack of abnormalities in any of key genetic drivers, supporting that these neoplasms represent a novel entity with an indolent clinical course. Given their mesenchymal transcriptomic features, we propose the designation of “sclerosing epithelioid mesenchymal neoplasm” of the pancreas.

    DOI: 10.1038/s41379-019-0334-5

  • Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma 10-year experience of a single institute 査読

    Keisuke Kodama, Kenzo Sonoda, Masako Kijima, Shinichiro Yamaguchi, Hiroshi Yagi, Masafumi Yasunaga, Tatsuhiro Ohgami, Ichiro Onoyama, Eisuke Kaneki, Kaoru Okugawa, Hideaki Yahata, Yoshihiro Ohishi, Yoshinao Oda, Kiyoko Kato

    Asia-Pacific Journal of Clinical Oncology   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ajco.13286

  • Quantitative evaluation of the intratumoral distribution of platinum in oxaliplatin-treated rectal cancer In situ visualization of platinum via synchrotron radiation X-ray fluorescence spectrometry 査読

    Ryo Koba, Hayato Fujita, Maiko Nishibori, Kiyoshi Saeki, Kinuko Nagayoshi, Yoshihiko Sadakari, Shuntaro Nagai, Oki Sekizawa, Kiyofumi Nitta, Tatsuya Manabe, Takashi Ueki, Tatsuhiro Ishida, Yoshinao Oda, Masafumi Nakamura

    International Journal of Cancer   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ijc.32592

  • Non-transmissible MV Vector with Segmented RNA Genome Establishes Different Types of iPSCs from Hematopoietic Cells 査読

    Takafumi Hiramoto, Maino Tahara, Jiyuan Liao, Yasushi Soda, Yoshie Miura, Ryo Kurita, Hiroshi Hamana, Kota Inoue, Hiroshi Kohara, Shohei Miyamoto, Yasuki Hijikata, Shinji Okano, Yoshiyuki Yamaguchi, Yoshinao Oda, Kenji Ichiyanagi, Hidehiro Toh, Hiroyuki Sasaki, Hiroyuki Kishi, Akihide Ryo, Atsushi Muraguchi, Makoto Takeda, Kenzaburo Tani

    Molecular Therapy   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ymthe.2019.09.007

  • Combined Evaluation of Tumor-Infiltrating CD8 + and FoxP3 + Lymphocytes Provides Accurate Prognosis in Stage IA Lung Adenocarcinoma 査読

    Fumihiko Kinoshita, Kazuki Takada, Yuichi Yamada, Yuka Oku, Keisuke Kosai, Yuki Ono, Kensuke Tanaka, Sho Wakasu, Taro Oba, Atsushi Osoegawa, Tetsuzo Tagawa, Mototsugu Shimokawa, Yoshinao Oda, Masaki Mori

    Annals of Surgical Oncology   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-019-08029-9

  • Risk factors for failure of vitrectomy cell block technique in cytological diagnosis of vitreoretinal lymphoma 査読

    Takako Ito, Atsunobu Takeda, Kohta Fujiwara, Eiichi Hasegawa, shintaro nakao, Yoshihiro Ohishi, Yoshinao Oda, Hiroshi Yoshikawa, Kohei Sonoda

    Graefe's Archive for Clinical and Experimental Ophthalmology   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00417-019-04266-6

  • Prognostic Impact of Programmed Death-Ligand 2 Expression in Primary Lung Adenocarcinoma Patients 査読

    Shinkichi Takamori, Kazuki Takada, Koichi Azuma, Tomoko Jogo, Mototsugu Shimokawa, Gouji Toyokawa, Fumihiko Hirai, Tetsuzo Tagawa, Akihiko Kawahara, Jun Akiba, Isamu Okamoto, Yoichi Nakanishi, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara

    Annals of Surgical Oncology   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-019-07231-z

  • Retroperitoneal schwannoma preoperatively diagnosed as liver metastasis from colon cancer A case report 査読

    Huanlin Wang, Tomoharu Yoshizumi, Shinji Itoh, Toru Ikegami, Noboru Harada, Yoshinao Oda, Masaki Mori

    International Journal of Surgery Case Reports   64   31 - 34   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijscr.2019.09.031

  • A Case of Undifferentiated Sarcoma in the Superior Vena Cava and Bilateral Cervical Veins 査読

    Hiroshi Kobayashi, Yuka Kobayashi, Sho Yuasa, Masayuki Okabe, Yuichi Yamada, Yoshinao Oda, Maria Debiec-Rychter, Brian P. Rubin, Toshimitsu Suzuki

    The American journal of case reports   19   1507 - 1514   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.12659/AJCR.911659

  • Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer 査読

    Hideaki Yahata, Hiroaki Kobayashi, Kenzo Sonoda, Keisuke Kodama, hiroshi yagi, Masafumi Yasunaga, Tatsuhiro Ogami, Ichiro Onoyama, Kaneki Eisuke, Okugawa Kaoru, Shingo Baba, Takuro Isoda, Yoshihiro Ohishi, Yoshinao Oda, Kiyoko Kato

    International Journal of Clinical Oncology   23 ( 6 )   1167 - 1172   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10147-018-1327-y

  • Prognostic Value of Preoperative Nutritional and Immunological Factors in Patients with Pancreatic Ductal Adenocarcinoma 査読

    Toshiya Abe, Kohei Nakata, Shin Kibe, Yasuhisa Mori, Yoshihiro Miyasaka, Kenoki Ouchida, Ohtsuka Takao, Yoshinao Oda, Masafumi Nakamura

    Annals of Surgical Oncology   25 ( 13 )   3996 - 4003   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-018-6761-6

  • Differences in PD-L1 expression on tumor and immune cells between lung metastases and corresponding primary tumors 査読

    Shinkichi Takamori, Kazuki Takada, Tetsuzo Tagawa, Gouji Toyokawa, Fumihiko Hirai, Nami Yamashita, Tatsuro Okamoto, Eiji Oki, Tomoharu Yoshizumi, Yoshinao Oda, Yoshihiko Maehara

    Surgical Oncology   27 ( 4 )   637 - 641   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.suronc.2018.08.001

  • CD44v9 is associated with epithelial-mesenchymal transition and poor outcomes in esophageal squamous cell carcinoma 査読

    Daisuke Taniguchi, Hiroshi Saeki, Yuichiro Nakashima, Kensuke Kudou, Ryota Nakanishi, Nobuhide Kubo, Kouji Andou, Eiji Oki, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   7 ( 12 )   6258 - 6268   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/cam4.1874

  • "pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma with Mucoepidermoid Carcinoma-like Features 査読

    Kiyoshi Saeki, Yoshihiro Ohishi, Ryota Matsuda, Naoki Mochidome, Yoshihiro Miyasaka, Hidetaka Yamamoto, Yutaka Koga, Yoshihiko Maehara, Masafumi Nakamura, Yoshinao Oda

    American Journal of Surgical Pathology   42 ( 11 )   1419 - 1428   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/PAS.0000000000001135

  • Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor. 招待 査読 国際誌

    Tatsuro Abe, Kenichi Kohashi,Junkichi Takemoto, Fumio Kinoshita, Masatoshi Eto,and Yoshinao Oda

    J Cancer   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.7150/jca.25279

  • The utility of muscle-sparing axillar skin crease incision with thoracoscopic surgery in children 査読

    Ryota Sozaki, Naonori Kawakubo, Kina Miyoshi, Satoshi Obata, Yoshiaki Kinoshita, Junkichi Takemoto, Kenichi Kouhashi, Yoshinao Oda, Tomoaki Taguchi

    Journal of Laparoendoscopic and Advanced Surgical Techniques   28 ( 11 )   1378 - 1382   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1089/lap.2018.0169

  • Radiotherapy for Langerhans cell histiocytosis with paraplegia A rare oncologic emergency case report in infancy and literature review 査読

    Kentaro Nakashima, Yuhki Koga, Yasunari Sakai, Hidetoshi Takada, Katsumi Harimaya, Ohga Saiji, Tomoaki Taguchi, Yoshinao Oda, Hiroshi Honda, Shoichi Ohga

    Brain and Development   40 ( 10 )   952 - 955   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.braindev.2018.05.016

  • Radiological features of programmed cell death-ligand 2-positive lung adenocarcinoma A single-institution retrospective study 査読

    Kazuki Takada, Gouji Toyokawa, Koichi Azuma, Shinkichi Takamori, Tomoko Jogo, Fumihiko Hirai, Tetsuzo Tagawa, Akihiko Kawahara, Jun Akiba, Isamu Okamoto, Yoichi Nakanishi, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara

    In Vivo   32 ( 6 )   1541 - 1550   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/invivo.11412

  • BUBR1 insufficiency is correlated with eNOS reduction experimentally in vitro and in vivo, and in gastric cancer tissue 査読

    Eisuke Kawakubo, Takuya Matsumoto, Keiji Yoshiya, Sho Yamashita, Tomoko Jogo, Hiroshi Saeki, Eiji Oki, Tadashi Furuyama, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   38 ( 11 )   6099 - 6106   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12960

  • BRCAness Combined With a Family History of Cancer Is Associated With a Poor Prognosis for Breast Cancer Patients With a High Risk of BRCA Mutations 査読

    Hitomi Mori, Makoto Kubo, Masaya Kai, Vittoria Vanessa Velasquez, Kanako Kurata, Mai Yamada, Masayuki Okido, Syoji Kuroki, Yoshinao Oda, Masafumi Nakamura

    Clinical Breast Cancer   18 ( 5 )   e1217 - e1227   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.clbc.2018.05.008

  • Significance of spread through air spaces in early-stage lung adenocarcinomas undergoing limited resection 査読

    Toyokawa G, Yamada Y, Tagawa T, Oda Y.

    Thorac Cancer.   ( 10 )   1255 - 1261   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1111/1759-7714.12828.

  • Prognostic impact of PD-L2 expression and association with PD-L1 in patients with small-cell lung cancer 査読

    Shinkichi Takamori, Kazuki Takada, Koichi Azuma, Yumiko Jogo, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Gouji Toyokawa, Fumihiko Hirai, Tetsuzo Tagawa, Isamu Okamoto, Yoichi Nakanishi, Akihiko Kawahara, Jun Akiba, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   38 ( 10 )   5903 - 5907   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12934

  • PD-L2 expression as a potential predictive biomarker for the response to anti-PD-1 drugs in patients with non-small cell lung cancer 査読

    Shinkichi Takamori, Kazuki Takada, Gouji Toyokawa, Koichi Azuma, Mototsugu Shimokawa, Tomoko Jogo, Yuichi Yamada, Fumihiko Hirai, Tetsuzo Tagawa, Akihiko Kawahara, Jun Akiba, Isamu Okamoto, Yoichi Nakanishi, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara

    Anticancer research   38 ( 10 )   5897 - 5901   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12933

  • Metastatic esophageal carcinosarcoma comprising neuroendocrine carcinoma, squamous cell carcinoma, and sarcoma A case report 査読

    Kenji Tsuchihashi, Shuji Arita, Minako Fujiwara, Kazuhide Iwasaki, Atsushi Hirano, Tomoyasu Yoshihiro, Kenta Nio, Yutaka Koga, Motohiro Esaki, hiroshi ariyama, Hitoshi Kusaba, Taiki Moriyama, Kenoki Ouchida, Eishi Nagai, Masafumi Nakamura, Yoshinao Oda, Koichi Akashi, Eishi Baba

    Medicine (United States)   97 ( 41 )   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MD.0000000000012796

  • Computed tomography features of resected lung adenocarcinomas with spread through air spaces 査読

    Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Takeshi Kamitani, Yuzo Yamasaki, Mototsugu Shimokawa, Yoshinao Oda, Yoshihiko Maehara

    Journal of Thoracic and Cardiovascular Surgery   156 ( 4 )   1670 - 1676.e4   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jtcvs.2018.04.126

  • CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication a comparison with its counterparts in the kidney and soft tissue 査読

    Yuka Yoshida, Sumihito Nobusawa, Satoshi Nakata, Mitsutoshi Nakada, Yoshiki Arakawa, Yohei Mineharu, Yasuo Sugita, Takako Yoshioka, Asuka Araki, Yuichiro Sato, Hideo Takeshima, Masahiko Okada, Akira Nishi, Tatsuya Yamazaki, Kenichi Kouhashi, Yoshinao Oda, Junko Hirato, Hideaki Yokoo

    Brain Pathology   28 ( 5 )   710 - 720   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/bpa.12585

  • Tumor-induced osteomalacia caused by a massive phosphaturic mesenchymal tumor of the acetabulum A case report 査読

    Kimitaka Nakamura, Masanobu Ohishi, Tomoya Matsunobu, Yasuharu Nakashima, Akio Sakamoto, Akira Maekawa, Yoshinao Oda, Yukihide Iwamoto

    Modern Rheumatology   28 ( 5 )   906 - 910   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3109/14397595.2016.1173322

  • Radiological features of IDO1+/PDL1+ lung adenocarcinoma A retrospective single-institution study 査読

    Kazuki Takada, Gouji Toyokawa, Tetsuzo Tagawa, Mototsugu Shimokawa, Kenichi Kouhashi, Akira Haro, Atsushi Osoegawa, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   38 ( 9 )   5295 - 5303   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12856

  • Low grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion A case report 査読

    Yurie Mikami, Shinsuke Fujii, Kenichi Kouhashi, Yuichi Yamada, Masafumi Moriyama, Shintarou Kawano, Seiji Nakamura, Yoshinao Oda, Tamotsu Kiyoshima

    Oncology Letters   16 ( 3 )   3889 - 3894   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3892/ol.2018.9115

  • Indoleamine 2,3-dioxygenase 1 and programmed cell death-ligand 1 co-expression correlates with aggressive features in lung adenocarcinoma 査読

    Yuka Kozuma, Kazuki Takada, Gouji Toyokawa, Kenichi Kouhashi, Mototsugu Shimokawa, Fumihiko Hirai, Tetsuzo Tagawa, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    European Journal of Cancer   101   20 - 29   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ejca.2018.06.020

  • Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer 査読

    Yuka Inoue, Nami Yamashita, Hiroyuki Kitao, Kimihiro Tanaka, Hiroshi Saeki, Eiji Oki, Yoshinao Oda, Eriko Tokunaga, Yoshihiko Maehara

    Clinical Breast Cancer   18 ( 4 )   e643 - e650   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.clbc.2017.11.008

  • Overexpression of mth1 and ogg1 proteins in ulcerative colitis-associated carcinogenesis 査読

    Yoshiteru Kumagae, Minako Hirahashi, Katsumi Takizawa, Hidetaka Yamamoto, Masaki Gushima, Motohiro Esaki, Takayuki Matsumoto, Masafumi Nakamura, Takanari Kitazono, Yoshinao Oda

    Oncology Letters   16 ( 2 )   1765 - 1776   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3892/ol.2018.8812

  • Neuroendocrine tumor of the pancreas with rhabdoid feature 査読

    Tetsuyuki Miyazaki, Shinichi Aishima, Minoru Fujino, Keigo Ozono, yuichiro kubo, yasuhiro ushijima, Takashi Osoegawa, Eikichi Ihara, Itou Tetsuhide, Ohtsuka Takao, Masafumi Nakamura, Yoshinao Oda

    Virchows Archiv   473 ( 2 )   247 - 252   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00428-018-2398-x

  • Cancer management in kabuki syndrome The first case of wilms tumor and a literature review 査読

    Hideto Teranishi, Yuhki Koga, Kentaro Nakashima, Eiji Morihana, Kanako Ishii, Yasunari Sakai, Tomoaki Taguchi, Yoshinao Oda, Noriko Miyake, Naomichi Matsumoto, Shoichi Ohga

    Journal of Pediatric Hematology/Oncology   40 ( 5 )   391 - 394   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MPH.0000000000001111

  • Visualizing energy charge in breast carcinoma tissues by MALDI mass-spectrometry imaging profiles of low-molecular-weight metabolites 査読

    Nobuhiro Torata, Makoto Kubo, Daisuke Miura, Kenoki Ouchida, yusuke mizuuchi, Yoshinori Fujimura, Eisuke Hayakawa, Masaya Kai, Yoshinao Oda, Kazuhiro Mizumoto, Makoto Hashizume, Masafumi Nakamura

    Anticancer research   38 ( 7 )   4267 - 4272   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12723

  • The significant influence of having children on the postoperative prognosis of patients with nonsmall cell lung cancer A propensity score-matched analysis 査読

    Shinkichi Takamori, Tetsuzo Tagawa, Gouji Toyokawa, Hiroki Ueo, Mototsugu Shimokawa, Fumihiko Kinoshita, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Takaki Akamine, Masakazu Katsura, Kazuki Takada, Fumihiko Hirai, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   7 ( 7 )   2860 - 2867   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/cam4.1539

  • Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade 査読

    Kentaro Tanaka, Toyoshi Yanagihara, Yuki Ikematsu, Hiroyuki Inoue, keiichi ota, Eiji Kashiwagi, Kunihiro Suzuki, Naoki Hamada, ario takeuchi, Katsunori Tatsugami, Masatoshi Eto, Kayo Ijichi, Yoshinao Oda, Kohei Otsubo, Yasuto Yoneshima, Eiji Iwama, Yoichi Nakanishi, Isamu Okamoto

    Oncotarget   9 ( 55 )   30587 - 30593   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18632/oncotarget.25743

  • A case of pseudoglandular hepatocellular carcinoma The usefulness of a multimodal approach 査読

    Hirofumi Watanabe, Yoshiki Asayama, Akihiro Nishie, Kosei Ishigami, yasuhiro ushijima, Daisuke Okamoto, nobuhiro fujita, Tomoharu Yoshizumi, Yoshinao Oda, Hiroshi Honda

    Radiology Case Reports   13 ( 3 )   689 - 692   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.radcr.2018.03.022

  • Class III β-Tubulin Overexpression Induces Chemoresistance to Eribulin in a Leiomyosarcoma Cell Line. 査読 国際誌

    2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1155/2018/8987568

  • Significance of Spread Through Air Spaces in Resected Pathological Stage I Lung Adenocarcinoma 査読

    Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Yoshinao Oda, Yoshihiko Maehara

    Annals of Thoracic Surgery   105 ( 6 )   1655 - 1663   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.athoracsur.2018.01.037

  • Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation 査読

    Shinkichi Takamori, Gouji Toyokawa, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Nobutaka Mukae, Fumihiko Hirai, Tetsuzo Tagawa, Yoshinao Oda, Toru Iwaki, Koji Iihara, Hiroshi Honda, Yoshihiko Maehara

    Anticancer research   38 ( 6 )   3731 - 3734   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12653

  • Prevalence of enhancer of zeste homolog 2 in patients with resected small cell lung cancer 査読

    Gouji Toyokawa, Kazuki Takada, Tetsuzo Tagawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Fumihiko Hirai, Yuichi Yamada, Ryuji Hamamoto, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   38 ( 6 )   3707 - 3711   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12649

  • CD163 is required for protumoral activation of macrophages in human and murine sarcoma 査読

    Daisuke Shiraishi, Yukio Fujiwara, Hasita Horlad, Yoichi Saito, Toyohisa Iriki, Junko Tsuboki, Pan Cheng, Naomi Nakagata, Hiroshi Mizuta, Hirofumi Bekki, Yasuharu Nakashima, Yoshinao Oda, Motohiro Takeya, Yoshihiro Komohara

    Cancer Research   78 ( 12 )   3255 - 3266   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1158/0008-5472.CAN-17-2011

  • Clinical Impact and Risk Factors for Skeletal Muscle Loss After Complete Resection of Early Non-small Cell Lung Cancer 査読

    Shinkichi Takamori, Gouji Toyokawa, Tatsuro Okamoto, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Kazuki Takada, Masakazu Katsura, Fumihiko Hirai, Fumihiro Shoji, Tetsuzo Tagawa, Yoshinao Oda, Hiroshi Honda, Yoshihiko Maehara

    Annals of Surgical Oncology   25 ( 5 )   1229 - 1236   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-017-6328-y

  • Successful treatment of growing teratoma syndrome of the lung by surgical resection A case report and literature review 査読

    Kensuke Tanaka, Gouji Toyokawa, Tetsuzo Tagawa, Kayo Ijichi, Naoki Haratake, Fumihiko Hirai, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   38 ( 5 )   3115 - 3118   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12571

  • Deregulated mucosal immune surveillance through gut-Associated regulatory t cells and PD-1 + t cells in human colorectal cancer 査読

    Hanae Fujimoto, Yoriko Saito, Kenoki Ouchida, Eiryo Kawakami, Saera Fujiki, Takashi Watanabe, Rintaro Ono, Akiko Kaneko, Shinsuke Takagi, Yuho Najima, Atsushi Hijikata, Lin Cui, Takashi Ueki, Yoshinao Oda, Shohei Hori, Osamu Ohara, Masafumi Nakamura, Takashi Saito, Fumihiko Ishikawa

    Journal of Immunology   200 ( 9 )   3291 - 3303   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.4049/jimmunol.1701222

  • Effect of cartilaginous endplates on extruded disc resorption in lumbar disc herniation 査読

    Kenichi Kawaguchi, Katsumi Harimaya, Yoshihiro Matsumoto, Mitsumasa Hayashida, Seiji Okada, Keiichiro Iida, Go Kato, Kuniyoshi Tsuchiya, Toshio Doi, Yoshinao Oda, Yukihide Iwamoto, Yasuharu Nakashima

    PloS one   13 ( 4 )   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0195946

  • Gastric cancer of "Crawling type" detected by additional gastrectomy after endoscopic submucosal resection 査読

    Yasuhiro Haruta, Ryota Nakanishi, Tomoko Jogo, Yuichiro Nakashima, Hiroshi Saeki, Eiji Oki, Minako Fujiwara, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   38 ( 4 )   2335 - 2338   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12479

  • Wnt/β-catenin signal alteration and its diagnostic utility in basal cell adenoma and histologically similar tumors of the salivary gland 査読

    214 ( 4 )   586 - 592   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Differential diagnosis among basal cell adenoma (BCA), basal cell adenocarcinoma (BCAC), adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) of the salivary gland can be challenging due to their similar histological appearance. Although frequent nuclear β-catenin expression and CTNNB1 mutations have been reported in BCA, further details of the Wnt/β-catenin signal alterations are unclear. The aim of this study was to assess the diagnostic utility of Wnt/β-catenin signal alteration in BCA and morphological mimics. We performed immunohistochemical staining for β-catenin and mutation analysis for Wnt/β-catenin-related genes (CTNNB1, APC, AXIN1 and AXIN2) in BCA (n = 34), BCAC (n = 3), ACC (n = 67) and PA (n = 31). We also analyzed ACC-specific MYB and MYBL1 gene rearrangements by fluorescence in situ hybridization (FISH). Nuclear β-catenin expression (≥3%) was present in 32/34 cases (94.1%) of BCA, and the nuclear β-catenin labeling index was significantly higher than in other tumor types (p = < 0.0001). In BCA, we found mutations in CTNNB1, APC and AXIN1 genes (41.1%, 2.9% and 8.8%, respectively). In BCAC, nuclear β-catenin expression with CTNNB1 mutation was present in 1/3 cases (33.3%). As for ACC, nuclear β-catenin expression was observed in 3/67 cases (4.4%), but all 3 cases harbored either MYB or MYBL1 gene rearrangement. The results suggest that nuclear β-catenin immunoreactivity with appropriate criteria may be helpful to distinguish BCA from histologically similar tumors. However, a minor subset of ACCs with nuclear β-catenin expression require careful diagnosis. In addition, Wnt/β-catenin signal alteration may play a role in the pathogenesis of BCA and BCAC.

    DOI: 10.1016/j.prp.2017.12.016

  • The novel selective pan-TRK inhibitor ONO-7579 exhibits antitumor efficacy against human gallbladder cancer in vitro 査読

    Makoto Kawamoto, Keigo Ozono, Yasuhiro Oyama, Akio Yamasaki, Yoshinao Oda, Hideya Ohnishi

    Anticancer research   38 ( 4 )   1979 - 1986   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12435

  • Successful chemotherapeutic treatment for metastatic littoral cell angioma A case report 査読

    Kotoe Takayoshi, Goro Doi, Nobuhiro Tsuruta, Tomoyasu Yoshihiro, Kenta Nio, Kenji Tsuchihashi, hiroshi ariyama, Jun Odawara, Shinji Shimoda, Kenichi Kouhashi, Yoshinao Oda, shinji itoh, Norifumi Harimoto, Yoshihiko Maehara, Hitoshi Kusaba, Koichi Akashi, Eishi Baba

    Medicine (United States)   97 ( 15 )   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MD.0000000000010378

  • PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements 査読

    Yasuto Yoneshima, Kayo Ijichi, Satoshi Anai, keiichi ota, Kohei Otsubo, Eiji Iwama, Kentaro Tanaka, Yoshinao Oda, Yoichi Nakanishi, Isamu Okamoto

    Lung Cancer   118   36 - 40   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.lungcan.2018.01.024

  • Osteogenic differentiation in dedifferentiated liposarcoma a study of 36 cases in comparison to the cases without ossification 査読

    Kyoko Yamashita, Kenichi Kouhashi, Yuichi Yamada, Takeaki Ishii, Yoshihiro Nishida, Hiroshi Urakawa, Ichiro Ito, Mitsuru Takahashi, Takeshi Inoue, Masafumi Ito, Yuuki Ohara, Yoshinao Oda, Shinya Toyokuni

    Histopathology   72 ( 5 )   729 - 738   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/his.13421

  • Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma 査読

    nobuko yasutake, Yoshihiro Ohishi, Kenichi Taguchi, Yuka Hiraki, Masafumi Oya, Yumi Oshiro, Mari Mine, Takeshi Iwasaki, Hidetaka Yamamoto, Kenichi Kouhashi, Kenzo Sonoda, Kiyoko Kato, Yoshinao Oda

    Histopathology   72 ( 5 )   739 - 748   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/his.13422

  • A novel histological examination with dynamic three-dimensional reconstruction from multiple immunohistochemically stained sections of a PD-L1-positive colon cancer 査読 国際誌

    Shotaro Korehisa, Tetsuo Ikeda, Shinji Okano, Hiroshi Saeki, Eiji Oki, Yoshinao Oda, Makoto Hashizume, Yoshihiko Maehara

    Histopathology   72 ( 4 )   697 - 703   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/his.13400

  • Liver-enriched transcription factor expression relates to chronic hepatic failure in humans 査読 国際誌

    Hepatology Communications   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 0.1002/hep4.1172.

  • Immunohistochemical evaluation of H3K27 trimethylation in malignant peripheral nerve sheath tumors 査読 国際誌

    Hiroshi Otsuka, Kenichi Kouhashi, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yuichi Yamada, Hidetaka Yamamoto, Yasuharu Nakashima, Yoshinao Oda

    Pathology Research and Practice   214 ( 3 )   417 - 425   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.prp.2017.12.015

  • High frequency of spread through air spaces in resected small cell lung cancer 査読 国際誌

    Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Fumihiko Hirai, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   38 ( 3 )   1821 - 1825   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12421

  • Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger 査読 国際誌

    Xiaopeng Bai, Eikichi Ihara, Katsuya Hirano, Yoshimasa Tanaka, Kayoko Nakano, Satomi Kita, Takahiro Iwamoto, Haruei Ogino, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, Yoshihiro Ogawa

    CMGH Cellular and Molecular Gastroenterology and Hepatology   5 ( 3 )   209 - 221   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jcmgh.2017.11.004

  • Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone 査読 国際誌

    Hidetaka Yamamoto, Takeshi Iwasaki, Yuichi Yamada, Yoshihiro Matsumoto, Hiroshi Otsuka, Masato Yoshimoto, Kenichi Kouhashi, Kenichi Taguchi, Ryohei Yokoyama, Yasuharu Nakashima, Yoshinao Oda

    Human Pathology   73   41 - 50   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2017.11.020

  • Association of preoperative serum CRP with PD-L1 expression in 508 patients with non-small cell lung cancer A comprehensive analysis of systemic inflammatory markers 査読 国際誌

    Takaki Akamine, Kazuki Takada, Gouji Toyokawa, Fumihiko Kinoshita, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Fumihiko Hirai, Tetsuzo Tagawa, Tatsuro Okamoto, Yasuto Yoneshima, Isamu Okamoto, Mototsugu Shimokawa, Yoshinao Oda, Yoichi Nakanishi, Yoshihiko Maehara

    Surgical Oncology   27 ( 1 )   88 - 94   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.suronc.2018.01.002

  • Clinical significance of programmed cell death-ligand 1 expression and the immune microenvironment at the invasive front of colorectal cancers with high microsatellite instability 査読 国際誌

    Shotaro Korehisa, Eiji Oki, Makoto Iimori, Yu Nakaji, Mototsugu Shimokawa, Hiroshi Saeki, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara

    International Journal of Cancer   142 ( 4 )   822 - 832   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ijc.31107

  • Surveillance of patients with intraductal papillary mucinous neoplasm with and without pancreatectomy with special reference to the incidence of concomitant pancreatic ductal adenocarcinoma 査読

    Kenjiro Date, Takao Ohtsuka, So Nakamura, Naoki Mochidome, Yasuhisa Mori, Yoshihiro Miyasaka, Yoshinao Oda, Masafumi Nakamura

    Surgery (United States)   163 ( 2 )   291 - 299   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.surg.2017.09.040

  • Value of Intraoperative Cytological and Pathological Sentinel Lymph Node Diagnosis in Fertility-Sparing Trachelectomy for Early-Stage Cervical Cancer 査読 国際誌

    Kenzo Sonoda, Hideaki Yahata, Okugawa Kaoru, Kaneki Eisuke, Tatsuhiro Ogami, Masafumi Yasunaga, Shingo Baba, Yoshinao Oda, Hiroshi Honda, Kiyoko Kato

    Oncology   94 ( 2 )   92 - 98   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000484049

  • The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research Standard operating procedures based on empirical analyses 査読 国際誌

    Yae Kanai, Hiroshi Nishihara, Yohei Miyagi, Tatsuhiro Tsuruyama, Kenichi Taguchi, Hiroto Katoh, Tomoyo Takeuchi, Masahiro Gotoh, Junko Kuramoto, Eri Arai, Hidenori Ojima, Ayako Shibuya, Teruhiko Yoshida, Toshiaki Akahane, Rika Kasajima, Kei Ichi Morita, Johji Inazawa, Takeshi Sasaki, Masashi Fukayama, Yoshinao Oda

    Pathology International   68 ( 2 )   63 - 90   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/pin.12631

  • Programmed Death-Ligand 1 Expression and EGFR Mutations in Multifocal Lung Cancer 査読 国際誌

    Naoki Haratake, Gouji Toyokawa, Kazuki Takada, Yuka Kozuma, Taichi Matsubara, Shinkichi Takamori, Takaki Akamine, Masakazu Katsura, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Annals of Thoracic Surgery   105 ( 2 )   448 - 454   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.athoracsur.2017.09.025

  • Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion 査読 国際誌

    Shinji Kohsaka, Tsuyoshi Saito, Keisuke Akaike, Yoshiyuki Suehara, Takuo Hayashi, Tatsuya Takagi, Kazuo Kaneko, Toshihide Ueno, Shinya Kojima, Kenichi Kouhashi, Hiroyuki Mano, Yoshinao Oda, Takashi Yao

    Human Pathology   72   167 - 173   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2017.08.017

  • PD-L1 expression according to the EGFR status in primary lung adenocarcinoma 査読 国際誌

    Kazuki Takada, Gouji Toyokawa, Tetsuzo Tagawa, Kenichi Kouhashi, Mototsugu Shimokawa, Takaki Akamine, Shinkichi Takamori, Fumihiko Hirai, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Lung Cancer   116   1 - 6   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.lungcan.2017.12.003

  • Mucinous adenocarcinoma of the thymus report of a case 査読 国際誌

    Fumihiko Kinoshita, Fumihiro Shoji, Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Tokujiro Yano, Yoshinao Oda, Yoshihiko Maehara

    General Thoracic and Cardiovascular Surgery   66 ( 2 )   111 - 115   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11748-017-0781-1

  • Histopathological and genetic review of phosphaturic mesenchymal tumours, mixed connective tissue variant 査読 国際誌

    Yuichi Yamada, Izumi Kinoshita, Kohashi Kenichi, Hidetaka Yamamoto, Takeshi Iwasaki, Hiroshi Otsuka, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yuki Kuma, Nokitaka Setsu, Yuki Koga, Yumi Honda, Takeshi Inoue, Hiroyuki Yanai, Kyoko Yamashita, Ichiro Ito, Mitsuru Takahashi, Shouichi Ohga, Masutaka Furue, Yasuharu Nakashima, Yoshinao Oda

    Histopathology   72 ( 3 )   460 - 471   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/his.13377

  • A combination of MTAP and BAP1 immunohistochemistry in pleural effusion cytology for the diagnosis of mesothelioma 査読 国際誌

    Yoshiaki Kinoshita, Tomoyuki Hida, Makoto Hamasaki, Shinji Matsumoto, Ayuko Sato, Tohru Tsujimura, Kunimitsu Kawahara, Kenzo Hiroshima, Yoshinao Oda, Kazuki Nabeshima

    Cancer cytopathology   126 ( 1 )   54 - 63   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/cncy.21928

  • Metyrapone-responsive ectopic acth-secreting pheochromocytoma with a vicious cycle via a glucocorticoid-driven positive-feedback mechanism 査読

    Minako Inoue, Ken Okamura, Chie Kitaoka, Fumio Kinoshita, Ryo Namitome, Udai Nakamura, Masaki Shiota, Kenichi Goto, Toshio Ohtsubo, Kiyoshi Matsumura, Yoshinao Oda, Masatoshi Eto, Takanari Kitazono

    Endocrine Journal   65 ( 7 )   755 - 767   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1507/endocrj.EJ18-0025

  • A case of solitary fibrous tumor 査読

    Tomoyo Matsuda, Yuko Haraguchi, Satoko Shibata-Kikuchi, Fumiyoshi Fushimi, Yuichi Yamada, Yoshinao Oda, Masutaka Furue

    Nishinihon Journal of Dermatology   80 ( 5 )   450 - 454   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2336/nishinihonhifu.80.450

  • ‘Microcystic pattern’ should be recognised as part of the morphological spectrum of solid-pseudopapillary neoplasm of the pancreas 査読 国際誌

    72 ( 2 )   216 - 226   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aim: Solid pseudopapillary neoplasm (SPN) is an uncommon pancreatic tumour characterised by solid and pseudopapillary growth patterns. We have observed SPNs can show a microcystic pattern (microcystic SPN), which has been poorly described and may be confused with microcystic neoplasms. We conducted the present study to clarify the clinicopathological and immunohistochemical features of microcystic SPNs. Methods and results: We examined a consecutive series of 44 SPNs and 10 serous cystadenomas (SCAs), and classified them into 13 microcystic SPNs (29.5%) and 31 conventional SPNs (70.5%). Clinicopathological analysis, immunohistochemical staining and mucin histochemistry were performed. Clear cell change, hyalinised stroma and haemorrhage were observed significantly more frequently in the microcystic SPNs compared to the conventional SPNs. Immunohistochemically, the microcystic SPNs showed significantly lower frequencies of CD10 (0%) and CD56 expression (62%) compared to the conventional SPNs (87%; P < 0.001, 90%; P < 0.0085, respectively). There were no significant differences in other clinicopathological and immunohistochemical features between the two groups (i.e. the nuclear expression of β-catenin, E-cadherin, progesterone receptor (PgR), lack of forkhead box (Fox)L2 and occasional oestrogen receptor (ER), AE1/AE3 expression). Microcystic SCAs lack such a characteristic immunophenotype. The myxoid stroma of microcystic SPNs contained hyaluronan revealed by Alcian blue stain with hyaluronidase digestion. Conclusion: We thus conclude that the microcystic pattern should be recognised as a part of the morphological spectrum of SPNs. Our findings may contribute to the correct diagnosis of the pancreatic neoplasms with the microcystic pattern. In addition, we speculate that stromal change caused by an accumulation of hyaluronan may contribute to the microcystic pattern of SPN.

    DOI: 10.1111/his.13376

  • Significance of Spread Through Air Spaces in Resected Lung Adenocarcinomas With Lymph Node Metastasis 査読 国際誌

    Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Fumihiko Hirai, Yoshinao Oda, Yoshihiko Maehara

    Clinical Lung Cancer   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.cllc.2018.04.002

  • SWI/SNF Chromatin-remodeling Complex Status in SMARCB1/INI1-preserved Epithelioid Sarcoma 査読

    Kenichi Kouhashi, Hidetaka Yamamoto, Yuichi Yamada, Izumi Kinoshita, Tomoaki Taguchi, Yukihide Iwamoto, Yoshinao Oda

    American Journal of Surgical Pathology   42 ( 3 )   312 - 318   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/PAS.0000000000001011

  • Role of SpyGlass-DStm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct 査読 国際誌

    Ohtsuka Takao, Yoshitaka Gotoh, Yohei Nakashima, Yoshifumi Okayama, So Nakamura, Makiko Morita, Mohammed Yahia Farrag Aly, Vittoria Vanessa D.M. Velasquez, Yasuhisa Mori, Yoshihiko Sadakari, Kohei Nakata, Yoshihiro Miyasaka, Kosei Ishigami, Nao Fujimori, Naoki Mochidome, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura

    Pancreatology   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.pan.2018.04.012

  • Laparoscopic surgery for congenital biliary dilatation a single-institution experience 査読 国際誌

    Mohammed Yahia Farrag Aly, Yasuhisa Mori, Yoshihiro Miyasaka, Ohtsuka Takao, Yoshihiko Sadakari, Kohei Nakata, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura

    Surgery Today   48 ( 1 )   44 - 50   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00595-017-1545-3

  • Interstitial pneumonia caused by dabigatran 査読 国際誌

    Toyoshi Yanagihara, Norio Yamamoto, Yasuaki Kotetsu, Naoki Hamada, Eiji Harada, Kunihiro Suzuki, Kayo Ijichi, Yoshinao Oda, Yoichi Nakanishi

    Respiratory Medicine Case Reports   23   10 - 12   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.rmcr.2017.10.009

  • Hepatobiliary and Pancreatic Pregnancy induced hepatic veno-occlusive disease requiring liver transplantation 査読 国際誌

    Norifumi Harimoto, K. Yugawa, Toru Ikegami, M. Ohira, Yohei Mano, T. Motomura, Takeo Toshima, shinji itoh, N. Harada, Yuji Soejima, Tomoharu Yoshizumi, Yoshihiko Maehara, Yoshinao Oda

    Journal of Gastroenterology and Hepatology (Australia)   33 ( 1 )   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jgh.13975

  • Fever and skin involvement at diagnosis predicting the intractable langerhans cell histiocytosis 40 case-series in a single center 査読 国際誌

    Tetsuko Kobayashi, Yuhki Koga, masataka ishimura, Kentaro Nakashima, Wakako Kato, Hiroaki Ono, Motoshi Sonoda, Katsuhide Eguchi, Reiji Fukano, Satoshi Honjo, Yoshinao Oda, Shoichi Ohga

    Journal of Pediatric Hematology/Oncology   40 ( 3 )   e148 - e153   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MPH.0000000000001080

  • Feasibility of prophylactic pancreatojejunostomy in possible high-risk patients for prevention of pancreatic fistula during enucleation or limited pancreatic resection 査読 国際誌

    Ohtsuka Takao, Yasuhisa Mori, Takaaki Fujimoto, Yoshihiro Miyasaka, Kohei Nakata, Kenoki Ouchida, Eishi Nagai, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura

    American Surgeon   84 ( 1 )   149 - 153   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Fatal cardiac hemochromatosis in a patient with hereditary spherocytosis 査読 国際誌

    Takeo Fujino, Shujiro Inoue, Shunsuke Katsuki, Taiki Higo, Tomomi Ide, Yoshinao Oda, Hiroyuki Tsutsui

    International Heart Journal   59 ( 2 )   427 - 430   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1536/ihj.17-160

  • Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients 査読 国際誌

    Masakazu Katsura, Fumihiro Shoji, Tatsuro Okamoto, Shinichiro Shimamatsu, Fumihiko Hirai, Gouji Toyokawa, Yosuke Morodomi, Tetsuzo Tagawa, Yoshinao Oda, Yoshihiko Maehara

    Cancer Science   109 ( 1 )   154 - 165   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/cas.13422

  • Clinicopathologic and molecular characteristics of synchronous colorectal carcinoma with mismatch repair deficiency 査読 国際誌

    Kayoko Nakano, Hidetaka Yamamoto, Minako Fujiwara, Yutaka Koga, Shinichi Tsuruta, Eikichi Ihara, Eiji Oki, Masafumi Nakamura, Yoshihiro Ogawa, Yoshinao Oda

    American Journal of Surgical Pathology   42 ( 2 )   172 - 182   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/PAS.0000000000000947

  • Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer 査読 国際誌

    Shinkichi Takamori, Gouji Toyokawa, Isamu Okamoto, Kazuki Takada, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Nobutaka Mukae, Fumihiko Hirai, Tetsuzo Tagawa, Yoshinao Oda, Toru Iwaki, Koji Iihara, Yoichi Nakanishi, Yoshihiko Maehara

    Anticancer Research   38 ( 1 )   553 - 557   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12258

  • Cancer-testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non-uterine leiomyosarcoma 査読 国際誌

    Kunio Iura, Kenichi Kouhashi, Nobuko Yasutake, Takeaki Ishii, Akira Maekawa, Hirofumi Bekki, Hiroshi Otsuka, Yuichi Yamada, Hidetaka Yamamoto, Yoshihiro Ohishi, Yoshihiro Matsumoto, Yukihide Iwamoto, Yoshinao Oda

    Oncology Letters   15 ( 1 )   441 - 446   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3892/ol.2017.7274

  • An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation 査読 国際誌

    Hironori Mikumo, Toyoshi Yanagihara, Naoki Hamada, Mikiko Hashisako, Kayo Ijichi, Kunihiro Suzuki, Eiji Harada, Yasunori Shikada, Yoshinao Oda, Yoichi Nakanishi

    Respiratory Medicine Case Reports   24   92 - 94   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.rmcr.2018.04.016

  • A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors 査読 国際誌

    Yasuki Hijikata, Toshihiko Okazaki, Yoshihiro Tanaka, Mutsunori Murahashi, Yuichi Yamada, Kazunari Yamada, Atsushi Takahashi, Hiroyuki Inoue, Junji Kishimoto, Yoichi Nakanishi, Yoshinao Oda, Yusuke Nakamura, Kenzaburo Tani

    PLoS One   13 ( 1 )   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0187878

  • A novel fusion gene CRTC3-MAML2 in hidradenoma histopathological significance 査読 国際誌

    Yuki Kuma, Yuichi Yamada, Hidetaka Yamamoto, Kenichi Kouhashi, Takamichi Ito, Masutaka Furue, Yoshinao Oda

    Human Pathology   70   55 - 61   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2017.10.004

  • SMARCA4-deficient thoracic sarcoma report of a case and insights into how to reach the diagnosis using limited samples and resources 査読 国際誌

    Satoshi Kuwamoto, Michiko Matsushita, Kenichi Takeda, Natsumi Tanaka, Yukari Endo, Akira Yamasaki, Kenichi Kouhashi, Yoshinao Oda, Yasushi Horie

    Human Pathology   70   92 - 97   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2017.05.024

  • Protein Expression of Programmed Death 1 Ligand 1 and HER2 in Gastric Carcinoma 査読 国際誌

    Eiji Oki, Shinji Okano, Hiroshi Saeki, Yuichiro Umemoto, Koji Teraishi, Yu Nakaji, Kouji Andou, Yoko Zaitsu, Nami Yamashita, Masahiko Sugiyama, Yuichiro Nakashima, Kippei Ohgaki, Yoshinao Oda, Yoshihiko Maehara

    Oncology   93 ( 6 )   387 - 394   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000479231

  • In vivo and ex vivo methods of growing a liver bud through tissue connection 査読 国際誌

    Yusuke Yanagi, Koichi Nakayama, Tomoaki Taguchi, Shin Enosawa, Tadashi Tamura, Koichiro Yoshimaru, Toshiharu Matsuura, Makoto Hayashida, Kenichi Kouhashi, Yoshinao Oda, Takayoshi Yamaza, Eiji Kobayashi

    Scientific Reports   7 ( 1 )   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-017-14542-2

  • Histopathologic diversity of gastric cancers Relationship between enhancement pattern on dynamic contrast-enhanced CT and histological type 査読 国際誌

    Daisuke Tsurumaru, mitsutoshi miyasaka, Toshio Muraki, Akihiro Nishie, Yoshiki Asayama, Eiji Oki, Yoshinao Oda, Hiroshi Honda

    European Journal of Radiology   97   90 - 95   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ejrad.2017.10.018

  • Diagnostic application of BAP1 immunohistochemistry to differentiate pleural mesothelioma from metastatic pleural tumours 査読 国際誌

    Masayo Yoshimura, Yoshiaki Kinoshita, Makoto Hamasaki, Shinji Matsumoto, Tomoyuki Hida, Yoshinao Oda, Kazuki Nabeshima

    Histopathology   71 ( 6 )   1011 - 1014   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/his.13321

  • Association Between PD-L1 Expression and Metabolic Activity on 18F-FDG PET/CT in Patients with Small-sized Lung Cancer 査読 国際誌

    Kazuki Takada, Gouji Toyokawa, Tetsuzo Tagawa, Kenichi Kouhashi, Takaki Akamine, Shinkichi Takamori, Fumihiko Hirai, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   37 ( 12 )   7073 - 7082   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Brain-derived neurotrophic factor/tropomyosin-related kinase B signaling pathway contributes to the aggressive behavior of lung squamous cell carcinoma 査読 国際誌

    Keigo Ozono, Yoshihiro Ohishi, Hideya Ohnishi, Katsuya Nakamura, Junichi Motoshita, Masato Kato, Ryoichi Nakanishi, Masafumi Nakamura, Yoshinao Oda

    Laboratory Investigation   97 ( 11 )   1332 - 1342   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/labinvest.2017.45

  • S100P in Duodenal Fluid Is a Useful Diagnostic Marker for Pancreatic Ductal Adenocarcinoma 査読 国際誌

    Taketo Matsunaga, Ohtsuka Takao, Koichi Asano, Hideyo Kimura, Kenoki Ouchida, Hidehisa Kitada, Noboru Ideno, Yasuhisa Mori, Shoji Tokunaga, Yoshinao Oda, Sushovan Guha, Massimo Raimondo, Masafumi Nakamura, Masao Tanaka

    Pancreas   46 ( 10 )   1288 - 1295   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MPA.0000000000000940

  • Metabolic characteristics of programmed cell death-ligand 1-expressing lung cancer on 18F-fluorodeoxyglucose positron emission tomography/computed tomography 査読 国際誌

    Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Shingo Baba, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Fumihiro Shoji, Hiroshi Honda, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   6 ( 11 )   2552 - 2561   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/cam4.1215

  • Lingual alveolar soft part sarcoma responsive to pazopanib A case report 査読 国際誌

    Tomoyasu Yoshihiro, Kenji Tsuchihashi, Kenta Nio, Shuji Arita, Takafumi Nakano, Ryuji Yasumatsu, Rina Jiroumaru, hiroshi ariyama, Hitoshi Kusaba, Yoshinao Oda, Koichi Akashi, Eishi Baba

    Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries   96 ( 44 )   e8470   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MD.0000000000008470

  • Breast angiosarcoma without radiation history, putatively associated with subclinical lymphedema A case report and review of the Japanese literature 査読 国際誌

    Eriko Maehara, Chikage Mitoma, Gaku Tsuji, Takamichi Ito, Uchi Hiroshi, Yoshinao Oda, Masutaka Furue

    Journal of Dermatology   44 ( 10 )   e266 - e267   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/1346-8138.13917

  • Positive conversion of PD-L1 expression after treatments with chemotherapy and nivolumab 査読 国際誌

    Naoki Haratake, Gouji Toyokawa, Tetsuzo Tagawa, Yuka Kozuma, Taichi Matsubara, Shinkichi Takamori, Takaki Akamine, Yuichi Yamada, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   37 ( 10 )   5713 - 5717   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12009

  • Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1 査読 国際誌

    Yuki Ikematsu, Yasuto Yoneshima, Kayo Ijichi, Kentaro Tanaka, Taishi Harada, Yoshinao Oda, Yoichi Nakanishi, Isamu Okamoto

    Lung Cancer   112   230 - 231   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.lungcan.2017.07.020

  • Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course) A case report 査読 国際誌

    Yukihiko Okumura, Kenichi Kouhashi, Huanlin Wang, Masaki Kato, Yoshihiko Maehara, Yoshihiro Ogawa, Yoshinao Oda

    Pathology Research and Practice   213 ( 10 )   1322 - 1326   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.prp.2017.06.001

  • Chemoradiotherapy for solitary skeletal muscle metastasis from oesophageal cancer Case report and brief literature review 査読 国際誌

    Yoshiaki Fujimoto, Yuichiro Nakashima, Shun Sasaki, Tomoko Jogo, Kosuke Hirose, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Kensuke Kudou, Yu Nakaji, Ryota Nakanishi, Kouji Andou, Hiroshi Saeki, Eiji Oki, Minako Fujiwara, Yoshinao Oda, Yoshihiko Maehara

    Anticancer Research   37 ( 10 )   5687 - 5691   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.12005

  • Alteration of PDGFRβ-Akt-mTOR pathway signaling in fibrosarcomatous transformation of dermatofibrosarcoma protuberans 査読 国際誌

    67   60 - 68   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Dermatofibrosarcoma protuberans (DFSP) is a cutaneous mesenchymal tumor of intermediate malignancy and fibroblastic/myofibroblastic differentiation. Fibrosarcomatous (FS) component is a high-grade component of DFSP. The detailed oncogenic difference between DFSP and FS components is not clear. We thus investigated the Akt-mTOR pathway in both components. We used 65 tumor samples obtained from 65 patients. The phosphorylation of Akt-mTOR pathway proteins (Akt, mTOR, 4EBP1, and S6RP) and PDGFRα/β was assessed by immunohistochemical staining, the results of which were confirmed by Western blotting. The immunohistochemical results were as follows: in ordinary DFSP components, p-PDGFRα–positive tumors were 41.9% (18/43 cases), p-PDGFRβ 55.8% (24/43 cases), p-Akt 51.2% (22/43 cases), p-mTOR 39.5% (17/43 cases), p-4EBP1 46.5% (20/43 cases), and p-S6RP 41.8% (18/43 cases); in DFSP components of FS-DFSP, 52.6% (10/19 cases), 47.4% (9/19 cases), 52.6% (10/19 cases), 36.8% (7/19 cases), 52.6% (10/19 cases), and 52.6% (10/19 cases); and in FS components, 45.5% (10/22 cases), 36.4% (8/22 cases), 72.7% (16/22 cases), 54.5% (12/22 cases), 72.7% (16/22 cases), and 68.2% (15/22 cases), respectively. There were significant positive correlations of the phosphorylation of most of the Akt-mTOR pathway proteins (p-Akt, p-mTOR, p-4EBP1, and p-S6RP) with each other (P <.05). Phospho-PDGFRβ was well correlated with the phosphorylation of Akt-mTOR pathway proteins in DFSP components of ordinary and FS-DFSPs, but these correlations were weaker in FS components. This study suggested the association of activation of Akt-mTOR pathway proteins and PDGFR with the progression of DFSP to FS. The Akt-mTOR pathway is thus a potential therapeutic target in imatinib-resistant DFSP/FS.

    DOI: 10.1016/j.humpath.2017.07.001

  • MAGEA4 expression in bone and soft tissue tumors its utility as a target for immunotherapy and diagnostic marker combined with NY-ESO-1 査読 国際誌

    Kunio Iura, Kenichi Kouhashi, Takeaki Ishii, Akira Maekawa, Hirofumi Bekki, Hiroshi Otsuka, Yuichi Yamada, Hidetaka Yamamoto, Yoshihiro Matsumoto, Yukihide Iwamoto, Yoshinao Oda

    Virchows Archiv   471 ( 3 )   383 - 392   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00428-017-2206-z

  • Highlighted version successful resection of a tracheal metastasis of rectal cancer A case report 査読 国際誌

    Takaki Akamine, Gouji Toyokawa, Kenichi Kouhashi, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Journal of Thoracic Disease   9 ( 9 )   E797 - E800   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21037/jtd.2017.07.94

  • High Frequency of Programmed Death-ligand 1 Expression in Emphysematous Bullae-associated Lung Adenocarcinomas 査読

    18 ( 5 )   504 - 511.e1   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Our objective is to clarify the prevalence of programmed death-ligand-1 (PD-L1) expression in emphysematous bullae (EB)-associated lung adenocarcinomas. Seventy patients (19.0%) were positive for PD-L1 expression. Thirty-six (44.4%) and 29 (58.0%) of 81 and 50 patients with EB and cancer adjoining EB, respectively, were positive for PD-L1 expression. EB-associated lung adenocarcinomas express PD-L1 protein more frequently than those without EB. Objective Emphysematous bullae (EB) are known to be associated with a high incidence of lung cancer; however, the reason for this has yet to be elucidated. The objective of the present study was to clarify the prevalence of programmed death-ligand-1 (PD-L1) expression in EB-associated lung adenocarcinomas. Patients and Methods A total of 369 patients with resected lung adenocarcinoma whose preoperative computed tomography findings were available for the examination of EB were analyzed for PD-L1 expression by immunohistochemistry and evaluated to determine the association between PD-L1 expression and EB-related adenocarcinomas. Results Among 369 patients, EB and cancer adjoining EB (Ca-ADJ) were identified in 81 (22.0%) and 50 (13.6%) patients, respectively. EB and Ca-ADJ were significantly associated with male gender, a smoking habit, a decreased forced expiratory volume in 1 second, a relatively higher tumor grade, advanced T status and stage, the presence of pleural and vessel invasion, invasive pathologic subtypes, and wild-type epidermal growth factor receptor. Seventy patients (19.0%) were positive for PD-L1 expression, whereas the remaining 299 patients (81.0%) were negative. Thirty-six (44.4%) and 29 (58.0%) of 81 and 50 patients with EB and Ca-ADJ, respectively, were positive for PD-L1 expression, which was shown to be significant by the Fisher exact test (P &#x003C; .001 and P &#x003C; .001, respectively). Among the 81 lung adenocarcinomas with EB, Ca-ADJ was significantly associated with PD-L1 expression (P = .021). In a multivariate analysis, the presence of Ca-ADJ was found to be an independent predictor of PD-L1 expression. Conclusions EB-associated lung adenocarcinomas express PD-L1 protein more frequently than those without EB.

    DOI: 10.1016/j.cllc.2016.11.011

  • Soft tissue sarcomas From a morphological to a molecular biological approach 査読 国際誌

    Yoshinao Oda, Hidetaka Yamamoto, Kenichi Kouhashi, Yuichi Yamada, Kunio Iura, Takeaki Ishii, Akira Maekawa, Hirofumi Bekki

    Pathology International   67 ( 9 )   435 - 446   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/pin.12565

  • Clinical significance of circumportal pancreas, a rare congenital anomaly, in pancreatectomy 査読 国際誌

    Ohtsuka Takao, Yasuhisa Mori, Kosei Ishigami, Takaaki Fujimoto, Yoshihiro Miyasaka, Kohei Nakata, Kenoki Ouchida, Eishi Nagai, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura

    American Journal of Surgery   214 ( 2 )   267 - 272   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.amjsurg.2016.11.018

  • Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions 査読 国際誌

    Mio Tanaka, Kenichi Kouhashi, Kei Kushitani, Misa Yoshida, Sho Kurihara, Masumi Kawashima, Yuka Ueda, Ryota Sozaki, Yoshiaki Kinoshita, Yoshinao Oda, Yukio Takeshima, Eiso Hiyama, Tomoaki Taguchi, Yukichi Tanaka

    Human Pathology   66   177 - 182   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2017.06.013

  • Discrepancy in programmed cell death-ligand 1 between primary and metastatic non-small cell lung cancer 査読 国際誌

    Shinkichi Takamori, Gouji Toyokawa, Isamu Okamoto, Kazuki Takada, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Masakazu Katsura, Nobutaka Mukae, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Toru Iwaki, Koji Iihara, Yoichi Nakanishi, Yoshihiko Maehara

    Anticancer Research   37 ( 8 )   4223 - 4228   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.11813

  • Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer 査読 国際誌

    Takatoshi Fujishita, Tatsuro Okamoto, Takaki Akamine, Shinkichi Takamori, Kazuki Takada, Masakazu Katsura, Gouji Toyokawa, Fumihiro Shoji, Mototsugu Shimokawa, Yoshinao Oda, Yusaku Nakabeppu, Yoshihiko Maehara

    Lung Cancer   109   52 - 57   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.lungcan.2017.04.012

  • The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer 査読 国際誌

    Daisuke Imai, Tomoharu Yoshizumi, Shinji Okano, Hideaki Uchiyama, Toru Ikegami, Norifumi Harimoto, shinji itoh, Yuji Soejima, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   6 ( 7 )   1614 - 1626   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/cam4.1087

  • SLC2A1/GLUT1 expression in mural nodules of intraductal papillary mucinous neoplasm of the pancreas 査読 国際誌

    Yasunori Oda, Shinichi Aishima, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Tetsuyuki Miyazaki, Masao Tanaka, Yoshinao Oda

    Human Pathology   65   71 - 78   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2017.03.008

  • Molecular Characteristics of Pancreatic Ductal Adenocarcinomas with High-Grade Pancreatic Intraepithelial Neoplasia (PanIN) Are Different from Those without High-Grade PanIN 査読 国際誌

    Tetsuyuki Miyazaki, Yoshihiro Ohishi, Yoshihiro Miyasaka, Yasunori Oda, Shinichi Aishima, Keigo Ozono, Atsushi Abe, Eishi Nagai, Masafumi Nakamura, Yoshinao Oda

    Pathobiology   84 ( 4 )   192 - 201   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000455194

  • HIF-1α, MDM2, CDK4, and p16 expression in ischemic fasciitis, focusing on its ischemic condition 査読 国際誌

    471 ( 1 )   117 - 122   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Ischemic fasciitis is a benign myofibroblastic lesion, occurring in the sacral region or proximal thigh of elderly or bedridden individuals. The pathogenesis of ischemic fasciitis is thought to be based on ischemic condition; however, it has never been demonstrated. In this study, we examined the expression of ischemia-associated proteins in ischemic fasciitis by immunohistochemical and genetic methods. Specifically, this study aimed to reveal the expression of HIF-1α, MDM2, CDK4, p16, and gene amplification of MDM2 gene. Seven cases of ischemic fasciitis from among the soft-tissue tumors registered at our institution were retrieved. Histopathological findings were as follows: poorly demarcated nodular masses, a proliferation of spindle-shaped fibroblastic or myofibroblastic cells with oval nuclei and eosinophilic or pale cytoplasm, zonal fibrinous deposition, pseudocystic degeneration, granulation-like proliferation of capillary vessels, ganglion-like cells, myxoid or hyalinized stroma, and chronic inflammatory infiltration. Immunohistochemically, the spindle cells were positive for HIF-1α (7/7 cases), MDM2 (4/7 cases), CDK4 (4/7 cases), p16 (7/7 cases), p53 (2/7 case), cyclin D1 (7/7 cases), and alpha-smooth muscle actin (6/7 cases). Neither MDM2 gene amplification nor USP6 gene split signal was detected in any case. Overexpression of the above proteins may be associated with the pathogenic mechanism of ischemic fasciitis. It is noted that the immunohistochemical positivity of MDM2, CDK4, and p16 do not necessarily indicate malignant neoplasm such as dedifferentiated liposarcoma.

    DOI: 10.1007/s00428-017-2122-2

  • Clinical implications of the novel cytokine IL-38 expressed in lung adenocarcinoma Possible association with PD-L1 expression 査読 国際誌

    Kazuki Takada, Tatsuro Okamoto, Masaki Tominaga, Koji Teraishi, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Gouji Toyokawa, Fumihiro Shoji, Masaki Okamoto, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara

    PLoS One   12 ( 7 )   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0181598

  • A exceptional collision tumor of primary adrenal angiosarcoma and non-functioning adrenocortical adenoma 査読 国際誌

    Katsumi Takizawa, Kenichi Kouhashi, Takahito Negishi, Kenichi Taguchi, Yuichi Yamada, Motonobu Nakamura, Yoshinao Oda

    Pathology Research and Practice   213 ( 6 )   702 - 705   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.prp.2017.04.017

  • Relevance Between Programmed Death Ligand 1 and Radiologic Invasiveness in Pathologic Stage I Lung Adenocarcinoma 査読 国際誌

    Gouji Toyokawa, Kazuki Takada, Tatsuro Okamoto, Satoshi Kawanami, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Masakazu Katsura, Yuichi Yamada, Fumihiro Shoji, Shingo Baba, Takeshi Kamitani, Yoshinao Oda, Hiroshi Honda, Yoshihiko Maehara

    Annals of Thoracic Surgery   103 ( 6 )   1750 - 1757   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.athoracsur.2016.12.025

  • Programmed death-ligand 1 expression at tumor invasive front is associated with epithelial-mesenchymal transition and poor prognosis in esophageal squamous cell carcinoma 査読 国際誌

    Satoshi Tsutsumi, Hiroshi Saeki, Yuichiro Nakashima, Shuhei Ito, Eiji Oki, Masaru Morita, Yoshinao Oda, Shinji Okano, Yoshihiko Maehara

    Cancer Science   108 ( 6 )   1119 - 1127   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/cas.13237

  • Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma 査読 国際誌

    Yoshiki Asayama, Akihiro Nishie, Kosei Ishigami, yasuhiro ushijima, Yukihisa Takayama, Daisuke Okamoto, nobuhiro fujita, Ohtsuka Takao, Tomoharu Yoshizumi, Shinichi Aishima, Yoshinao Oda, Hiroshi Honda

    European Radiology   27 ( 6 )   2563 - 2569   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00330-016-4621-y

  • Low-grade intraductal carcinoma (low-grade cribriform cystadenocarcinoma) with tumor-associated lymphoid proliferation of parotid gland 査読 国際誌

    Toshimitsu Nishijima, Hidetaka Yamamoto, Takafumi Nakano, Yui Hatanaka, Ken ichi Taguchi, Muneyuki Masuda, Yoshinao Oda

    Pathology Research and Practice   213 ( 6 )   706 - 709   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.prp.2017.02.019

  • Isthmic-vaginal cytological findings after a trachelectomy for early-stage cervical cancer 査読 国際誌

    Kenzo Sonoda, H. Yahata, Okugawa Kaoru, Kaneki Eisuke, K. Nakatsuki, M. Naka, N. Terado, F. Ookubo, Yoshinao Oda, Tsunehisa Kaku, Kiyoko Kato

    Cytopathology   28 ( 3 )   243 - 245   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/cyt.12379

  • Immunostaining for Hu C/D and CD56 is useful for a definitive histopathological diagnosis of congenital and acquired isolated hypoganglionosis 査読 国際誌

    Koichiro Yoshimaru, Tomoaki Taguchi, Satoshi Obata, Junkichi Takemoto, Yoshiaki Takahashi, Tsuyoshi Iwanaka, Yusuke Yanagi, Masaaki Kuda, kina miyoshi, Toshiharu Matsuura, Yoshiaki Kinoshita, Takako Yoshioka, Atsuko Nakazawa, Yoshinao Oda

    Virchows Archiv   470 ( 6 )   679 - 685   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00428-017-2128-9

  • High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer 査読 国際誌

    Sho Nishimura, Eiji Oki, Kouji Andou, Makoto Iimori, Yu Nakaji, Yuichiro Nakashima, Hiroshi Saeki, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   6 ( 6 )   1453 - 1464   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/cam4.1090

  • Expression of protease-activated receptor-2 (PAR-2) is related to advanced clinical stage and adverse prognosis in ovarian clear cell carcinoma 査読 国際誌

    Murasaki Aman, Yoshihiro Ohishi, Hiroko Imamura, Tomoko Shinozaki, Nobuko Yasutake, Kiyoko Kato, Yoshinao Oda

    Human Pathology   64   156 - 163   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2017.04.008

  • Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma 査読 国際誌

    Takeaki Ishii, Kenichi Kouhashi, Hiroshi Ootsuka, Kunio Iura, Akira Maekawa, Yuichi Yamada, Hirofumi Bekki, Masato Yoshimoto, Hidetaka Yamamoto, Yukihide Iwamoto, Yoshinao Oda

    Pathology Research and Practice   213 ( 6 )   634 - 638   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.prp.2017.04.022

  • Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma 査読 国際誌

    Huanlin Wang, Kenichi Kouhashi, Tomoharu Yoshizumi, Yukihiko Okumura, Yuki Tanaka, Masahiro Shimokawa, Takeshi Iwasaki, Shinichi Aishima, Yoshihiko Maehara, Yoshinao Oda

    Human Pathology   64   69 - 75   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2017.03.007

  • Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors 査読 国際誌

    Hirofumi Bekki, Hidetaka Yamamoto, Katsumi Takizawa, Takeshi Iwasaki, Hiroshi Otsuka, Yuichi Yamada, Kenichi Kouhashi, Katsumi Harimaya, Yukihide Iwamoto, Yoshinao Oda

    Pathology Research and Practice   213 ( 6 )   674 - 679   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.prp.2016.12.001

  • Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice 査読 国際誌

    Sho Endo, Kohei Nakata, Kenoki Ouchida, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Kazuhiro Koikawa, Takashi Okumura, Masafumi Sada, Kohei Horioka, Biao Zheng, Yusuke Mizuuchi, Chika Iwamoto, Masaharu Murata, Taiki Moriyama, Yoshihiro Miyasaka, Ohtsuka Takao, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura

    Gastroenterology   152 ( 6 )   1492 - 1506.e24   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1053/j.gastro.2017.01.010

  • The relationship between the expression of FOXA1 and GATA3 and the efficacy of neoadjuvant endocrine therapy 査読 国際誌

    Kimihiro Tanaka, Eriko Tokunaga, Nami Yamashita, Yasuaki Sagara, Yasuyo Ohi, Kenichi Taguchi, Shinji Ohno, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara

    Breast Cancer   24 ( 3 )   384 - 392   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s12282-016-0714-3

  • Severe Aplastic Anemia during Osimertinib Therapy in a Patient with EGFR Tyrosine Kinase Inhibitor–Resistant Non–Small Cell Lung Cancer 査読 国際誌

    12 ( 5 )   e46 - e47   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jtho.2016.12.023

  • Primary extraskeletal osteosarcoma a clinicopathological study of 18 cases focusing on MDM2 amplification status 査読 国際誌

    Kyoko Yamashita, Kenichi Kouhashi, Yuichi Yamada, Yoshihiro Nishida, Hiroshi Urakawa, Yoshinao Oda, Shinya Toyokuni

    Human Pathology   63   63 - 69   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2017.02.007

  • Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor 査読 国際誌

    Fukushima S, Endo M, Matsumoto Y, Fukushi JI, Matsunobu T, Kawaguchi KI, Setsu N, IIda K, Yokoyama N, Nakagawa M, Yahiro K, Oda Y, Iwamoto Y, Nakashima Y.

    PLoS One   12 ( 5 )   e0178064   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0178064

  • Phosphorylation of STAT3 in undifferentiated pleomorphic sarcoma is correlated with a favorable prognosis 査読 国際誌

    Hirofumi Bekki, Kenichi Kouhashi, Yuichi Yamada, Kunio Iura, Takeaki Ishii, Akira Maekawa, Hiroshi Otsuka, Hidetaka Yamamoto, Michiyuki Hakozaki, Kazuki Nabeshima, Yukihide Iwamoto, Yoshinao Oda

    Pathobiology   84 ( 3 )   161 - 169   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000448524

  • Molecular Evidence for Monoclonal Skip Progression in Main Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas 査読 国際誌

    Kenjiro Date, Ohtsuka Takao, Takaaki Fujimoto, Koji Tamura, Hideyo Kimura, Taketo Matsunaga, Naoki Mochidome, Tetsuyuki Miyazaki, Yasuhisa Mori, Yoshinao Oda, Masafumi Nakamura, Masao Tanaka

    Annals of Surgery   265 ( 5 )   969 - 977   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/SLA.0000000000001755

  • Clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer 査読 国際誌

    Toshiya Abe, Kenoki Ouchida, Sho Endo, Fumihiko Ookubo, Yasuhisa Mori, Kohei Nakata, Yoshihiro Miyasaka, Tatsuya Manabe, Ohtsuka Takao, Eishi Nagai, Yoshinao Oda, Masafumi Nakamura

    Surgery   161 ( 4 )   951 - 958   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.surg.2016.10.035

  • Oncogenic roles of SMARCB1/INI1 and its deficient tumors 査読 国際誌

    Kenichi Kouhashi, Yoshinao Oda

    Cancer Science   108 ( 4 )   547 - 552   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/cas.13173

  • Long-term outcomes of type I thyroplasty with silicone implantation Assessment of excised laryngeal tissue from a patient with secondary hypopharyngeal carcinoma 査読 国際誌

    Kazuo Adachi, Toshiro Umezaki, Toshimitsu Nishijima, Hidetaka Yamamoto, Yoshinao Oda

    Auris Nasus Larynx   44 ( 2 )   245 - 248   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.anl.2016.07.007

  • Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes 査読 国際誌

    Yuichi Yamada, Masaaki Kuda, Kenichi Kouhashi, Hidetaka Yamamoto, Junkichi Takemoto, Takeaki Ishii, Kunio Iura, Akira Maekawa, Hirofumi Bekki, Takamichi Ito, Hiroshi Otsuka, Makoto Kuroda, Yumi Honda, Shinji Sumiyoshi, Takeshi Inoue, Naoe Kinoshita, Atsushi Nishida, Kyoko Yamashita, Ichiro Ito, Shizuo Komune, Tomoaki Taguchi, Yukihide Iwamoto, Yoshinao Oda

    Virchows Archiv   470 ( 4 )   373 - 380   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00428-017-2072-8

  • Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients with Suspected Insulinoma 査読 国際誌

    Keijiro Ueda, Ken Kawabe, Lingaku Lee, Yuichi Tachibana, Nao Fujimori, Hisato Igarashi, Yoshinao Oda, Robert T. Jensen, Ryoichi Takayanagi, Tetsuhide Ito

    Pancreas   46 ( 4 )   476 - 481   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MPA.0000000000000772

  • Cancer-testis antigen expression in synovial sarcoma: NY-ESO-1, PRAME, MAGEA4, and MAGEA1 査読 国際誌

    HUMAN PATHOLOGY   61   130 - 139   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.humpath.2016.12.006

  • Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor 査読

    Fukushima S, Endo M, Matsumoto Y, Fukushi JI, Matsunobu T, Kawaguchi KI, Setsu N, IIda K, Yokoyama N, Nakagawa M, Yahiro K, Oda Y, Iwamoto Y, Nakashima Y.

    PLoS One.   12 ( 5 )   e0178064   2017年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1371/journal.pone.0178064.

  • Elevated metabolic activity on 18f-fdg pet/ct is associated with the expression of ezh2 in non-small cell lung cancer 査読

    Gouji Toyokawa, Kazuki Takada, Tatsuro Okamoto, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Fumihiro Shoji, Ryuji Hamamoto, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   37 ( 3 )   1393 - 1401   2017年3月

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    記述言語: