Updated on 2024/07/28

Information

 

写真a

 
AISHIMA SHINICHI
 
Organization
Faculty of Medical Sciences Department of Basic Medicine Professor
Kyushu University Hospital Division of Diagnostic Pathology(Joint Appointment)
School of Medicine Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medical Sciences(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426060
Profile
Pathological research for liver, biliary system and pancreas

Degree

  • The Role of Thymidine Phosphorylase and Thrombospondin-1 in Angiogenesis and Progression of Intrahepatic Cholangiocarcinoma

Research History

  • 国家公務員共済組合連合会 浜の町病院 病理医長 2005年4月~2008年3月

    国家公務員共済組合連合会 浜の町病院 病理医長 2005年4月~2008年3月

  • 佐賀大学医学部 病因病態科学講座診断病理学分野 教授 2014年2月~2023年6月

Research Interests・Research Keywords

  • Research theme:Liver carcinogenesis of NBNC background Liver carcinogenesis of MASLD Tumor microenvironment of intrahepatic cholangiocarcinoma Premalignant condition of gallbladder cancer

    Keyword:Bile duct cancer, liver cancer

    Research period: 2023.9 - 2023.12

Awards

  • 学術奨励賞

    2010.9   日本癌学会  

  • 学術研究賞(A演説)

    2007.11   日本病理学会  

Papers

  • 奈良宣言(ALT over 30)のMASLD(metabolic dysfunction-associated steatotic liver disease)における臨床的意義の検証

    川中 美和, 藤井 英樹, 岩城 慶大, 林 秀樹, 豊田 秀徳, 大枝 敏, 兵庫 秀幸, 森下 朝洋, 宗景 玄祐, 川田 一仁, 堤 翼, 澤田 康司, 前城 達次, 飛田 博史, 吉田 雄一, 内藤 雅文, 荒木 亜寿香, 新垣 伸吾, 川口 巧, 則武 秀尚, 小野 正文, 正木 勉, 安田 諭, 冨田 栄一, 米田 正人, 徳重 明央, 鎌田 佳宏, 高橋 宏和, 植田 真一郎, 相島 慎一, 角田 圭雄, 岡上 武, 中島 淳, Japan Study Group of Nonalcoholic Fatty Liver Disease(JSG-NAFLD)

    肝臓   65 ( 4 )   186 - 191   2024.4

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    Language:Japanese  

    DOI: 10.2957/kanzo.65.186

  • Accuracy of the Enhanced Liver Fibrosis Test in Patients With Type 2 Diabetes Mellitus and Its Clinical Implications Reviewed International journal

    @Arai T, @Takahashi H, @Seko Y, @Toyoda H, @Hayashi H, @Yamaguchi K, @Iwaki M, @Yoneda M, @Shima T, @Fujii H, @Morishita A,@Kawata K, @Tomita K, @Kawanaka M, @Yoshida Y, @Ikegami T, @Notsumata K, @Oeda S, @Atsukawa M, @Kamada Y, @Sumida Y, @Fukushima H, @Miyoshi E, Aishima S, @Okanoue T, @Itoh Y, @Nakajima A; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).

    Clin Gastroenterol Hepatol. 2024   22 ( 4 )   789 - 797   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cgh.2023.11.022.

  • Prognosis of biopsy-confirmed metabolic dysfunction-associated steatotic liver disease: A sub-analysis of the CLIONE study

    Michihiro Iwaki, Hideki Fujii, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

    Clinical and Molecular Hepatology   30 ( 2 )   225 - 234   2024.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3350/cmh.2023.0515

  • Interobserver agreement of pathologic classification and grading of tumoral intraductal pre-invasive neoplasms of the bile duct

    Yasuni Nakanuma, Yasunori Sato, Yuko Kakuda, Yoshiki Naito, Yuki Fukumura, Mana Fukushima, Hiroshi Minato, Shinichi Aishima, Nobuyuki Ohike, Toru Furukawa

    Annals of Diagnostic Pathology   69   2024.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.anndiagpath.2023.152247

  • Accuracy of the Enhanced Liver Fibrosis Test in Patients With Type 2 Diabetes Mellitus and Its Clinical Implications

    Taeang Arai, Hirokazu Takahashi, Yuya Seko, Hidenori Toyoda, Hideki Hayashi, Kanji Yamaguchi, Michihiro Iwaki, Masato Yoneda, Toshihide Shima, Hideki Fujii, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Yuichi Yoshida, Tadashi Ikegami, Kazuo Notsumata, Satoshi Oeda, Masanori Atsukawa, Yoshihiro Kamada, Yoshio Sumida, Hideaki Fukushima, Eiji Miyoshi, Shinichi Aishima, Takeshi Okanoue, Yoshito Itoh, Atsushi Nakajima

    Clinical Gastroenterology and Hepatology   22 ( 4 )   789 - 797.e8   2024.4

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    DOI: 10.1016/j.cgh.2023.11.022

  • Collision tumor of a papillary and follicular thyroid carcinoma: a case report

    16 ( 1 )   2023.12

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    Background: Papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) are common differentiated thyroid cancers, but the detection of a collision tumor is an extremely rare event. Case presentation: The patient was a 69-year-old Japanese female with multiple cervical lymph node swellings and a thyroid tumor. Preoperative fine needle aspiration cytology of the enlarged lymph node revealed a cytological diagnosis of papillary thyroid carcinoma (PTC). A total thyroidectomy, right cervical dissection and paratracheal dissection were performed. Histopathological and immunohistochemical analyses of resected specimens revealed a collision tumor of PTC and FTC. Multiple metastases of papillary carcinoma were found in the dissected lymph nodes. In the PTC lesion, IHC for BRAF (V600E) was positive but negative for the FTC lesion. Genetic analyses further revealed a TERT promoter C228T mutation in PTC and a NRAS codon 61 mutation in FTC. The patient died of recurrent cancer 8 months after surgery. Conclusions: A case of a collision tumor of PTC and FTC is very rare, and even fewer cases have been subjected to genetic scrutiny. The present case was successfully diagnosed by pathological examination using immunohistochemical and genetic analyses. The TERT promoter mutation in the PTC lesion was consistent with the aggressive behavior of the cancer.

    DOI: 10.1186/s13044-023-00167-3

  • Pseudohypercreatininemia after surgery for aortic dissection: a case report

    Ayako Tasaki, Makoto Fukuda, Yuki Ikeda, Masatora Yamasaki, Ikko Yamaguchi, Shinichi Aishima, Motoaki Miyazono

    BMC Nephrology   24 ( 1 )   2023.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12882-023-03275-2

  • Subcutaneous angiogenesis induced by transdermal delivery of gel-in-oil nanogel dispersion

    Yi Zhang, Jannatul Fardous, Yuuta Inoue, Ryota Doi, Asami Obata, Yusuke Sakai, Shinichi Aishima, Hiroyuki Ijima

    Biomaterials Advances   154   2023.11

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bioadv.2023.213628

  • 増大号 「胃と腸」式 読影問題集2023 応用と発展-考える画像診断が身につく 全消化管 3 Cases Case 3

    芥川 剛至, 沖井 詩織, 島村 拓弥, 相島 慎一, 江﨑 幹宏

    胃と腸   58 ( 10 )   1434 - 1437   2023.10

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    DOI: 10.11477/mf.1403203389

  • 肝胆道領域の病理診断

    相島 慎一

    日本臨床細胞学会雑誌   62 ( Suppl.2 )   409 - 409   2023.10

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  • Agile 3+ and Agile 4, noninvasive tests for liver fibrosis, are excellent formulae to predict liver-related events in nonalcoholic fatty liver disease

    Kouichi Miura, Hideki Hayashi, Yoshihiro Kamada, Hideki Fujii, Hirokazu Takahashi, Satoshi Oeda, Michihiro Iwaki, Takumi Kawaguchi, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

    Hepatology Research   53 ( 10 )   978 - 988   2023.10

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.13938

  • Palisading Adenocarcinoma: A Morphologically Unique Salivary Gland Tumor with a Neuroendocrine-like Appearance and a Predilection for the Sublingual Glands of Women

    Justin A. Bishop, Ilan Weinreb, Chris Van Vliet, Connull Leslie, Yoshitaka Utsumi, Shinichi Aishima, Junichi Shiraishi, Masamichi Koyama, Yoshiharu Nara, Masatomo Kimura, Doreen Palsgrove, Ying Ju Kuo, Ralph Gilbert, Jeffrey Gagan, Masato Nakaguro, Toshitaka Nagao

    American Journal of Surgical Pathology   47 ( 10 )   1176 - 1185   2023.10

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    DOI: 10.1097/PAS.0000000000002091

  • Identification of clinical phenotypes associated with poor prognosis in patients with nonalcoholic fatty liver disease via unsupervised machine learning

    Takanori Ito, Hikaru Morooka, Hirokazu Takahashi, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Masatoshi Ishigami, Yoshihiro Kamada, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

    Journal of Gastroenterology and Hepatology (Australia)   38 ( 10 )   1832 - 1839   2023.10

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    DOI: 10.1111/jgh.16326

  • A Case of Multicystic Biliary Hamartoma with a Marked Peribiliary Gland Component Successfully Treated by Purely Laparoscopic Anatomical Liver Resection

    Keita Kai, Takao Ide, Tomokazu Tanaka, Kumpei Yukimoto, Hiroyuki Irie, Hirokazu Noshiro, Shinichi Aishima

    Journal of Gastrointestinal Cancer   54 ( 3 )   996 - 999   2023.9

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    DOI: 10.1007/s12029-022-00893-1

  • M-PAST score is better than MAST score for the diagnosis of active fibrotic nonalcoholic steatohepatitis

    Kento Imajo, Yusuke Saigusa, Takashi Kobayashi, Koki Nagai, Shinya Nishida, Nobuyoshi Kawamura, Hiroyoshi Doi, Michihiro Iwaki, Asako Nogami, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Hiroyuki Kirikoshi, Satoshi Yasuda, Hidenori Toyoda, Hideki Hayashi, Shigehiro Kokubu, Daisuke Utsunomiya, Hirokazu Takahashi, Shinichi Aishima, Beom Kyung Kim, Nobuharu Tamaki, Satoru Saito, Masato Yoneda, Rohit Loomba, Atsushi Nakajima

    Hepatology Research   53 ( 9 )   844 - 856   2023.9

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    DOI: 10.1111/hepr.13927

  • Histological validation of atrial structural remodelling in patients with atrial fibrillation

    Yuya Takahashi, Takanori Yamaguchi, Toyokazu Otsubo, Kana Nakashima, Kodai Shinzato, Ryosuke Osako, Shigeki Shichida, Yuki Kawano, Akira Fukui, Atsushi Kawaguchi, Shinichi Aishima, Tsunenori Saito, Naohiko Takahashi, Koichi Node

    European Heart Journal   44 ( 35 )   3339 - 3353   2023.9

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    DOI: 10.1093/eurheartj/ehad396

  • Prediction of Liver-Related Events With a Combination of Liver Stiffness Measurements and Controlled Attenuation Parameters in Japanese Patients With Biopsy-Proven Non-alcoholic Fatty Liver Disease

    Hideki Hayashi, Yoshihiro Kamada, Hideki Fujii, Hirokazu Takahashi, Satoshi Oeda, Michihiro Iwaki, Takumi Kawaguchi, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

    Ultrasound in Medicine and Biology   49 ( 7 )   1658 - 1664   2023.7

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    DOI: 10.1016/j.ultrasmedbio.2023.03.023

  • Noninvasive tests predict liver-related events and mortality in patients with nonalcoholic fatty liver disease: sub-analysis of the CLIONE-Asia study

    Hiroshi Ishiba, Yoshio Sumida, Yoshihiro Kamada, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Atsushi Nakajima, Takeshi Okanoue

    Journal of Gastroenterology and Hepatology (Australia)   38 ( 6 )   896 - 904   2023.6

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    DOI: 10.1111/jgh.16144

  • Validation of the utility of Agile scores to identify advanced fibrosis and cirrhosis in Japanese patients with nonalcoholic fatty liver disease

    Satoshi Oeda, Yuya Seko, Hideki Hayashi, Taeang Arai, Michihiro Iwaki, Masato Yoneda, Toshihide Shima, Kazuo Notsumata, Tadashi Ikegami, Hideki Fujii, Hidenori Toyoda, Kouichi Miura, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Hiroshi Isoda, Kanji Yamaguchi, Hideaki Fukushima, Yoshihiro Kamada, Yoshio Sumida, Shinichi Aishima, Yoshito Itoh, Takeshi Okanoue, Atsushi Nakajima, Hirokazu Takahashi

    Hepatology Research   53 ( 6 )   489 - 496   2023.6

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    DOI: 10.1111/hepr.13890

  • Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease

    Hirokazu Takahashi, Miwa Kawanaka, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

    Nutrients   15 ( 9 )   2023.5

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    DOI: 10.3390/nu15092014

  • Multicenter, retrospective, cohort study shows platelet counts predict hepatocellular carcinoma development in patients with nonalcoholic fatty liver disease

    Hideki Fujii, Makoto Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Norifumi Kawada, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

    Hepatology Research   53 ( 5 )   391 - 400   2023.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.13884

  • Correction to: Heparin/Growth Factors-Immobilized Aligned Electrospun Nanofibers Promote Nerve Regeneration in Polycaprolactone/Gelatin-Based Nerve Guidance Conduits (Advanced Fiber Materials, (2023), 5, 2, (554-573), 10.1007/s42765-022-00244-6)

    Yasuhiro Ikegami, Muhammad Shafiq, Shinichi Aishima, Hiroyuki Ijima

    Advanced Fiber Materials   5 ( 2 )   696   2023.4

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    DOI: 10.1007/s42765-023-00261-z

  • Heparin/Growth Factors-Immobilized Aligned Electrospun Nanofibers Promote Nerve Regeneration in Polycaprolactone/Gelatin-Based Nerve Guidance Conduits

    Yasuhiro Ikegami, Muhammad Shafiq, Shinichi Aishima, Hiroyuki Ijima

    Advanced Fiber Materials   5 ( 2 )   554 - 573   2023.4

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    DOI: 10.1007/s42765-022-00244-6

  • Diagnostic accuracy of enhanced liver fibrosis test for nonalcoholic steatohepatitis-related fibrosis: Multicenter study

    Yuya Seko, Hirokazu Takahashi, Hidenori Toyoda, Hideki Hayashi, Kanji Yamaguchi, Michihiro Iwaki, Masato Yoneda, Taeang Arai, Toshihide Shima, Hideki Fujii, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Yuichi Yoshida, Tadashi Ikegami, Kazuo Notsumata, Satoshi Oeda, Yoshihiro Kamada, Yoshio Sumida, Hideaki Fukushima, Eiji Miyoshi, Shinichi Aishima, Takeshi Okanoue, Atsushi Nakajima, Yoshito Itoh

    Hepatology Research   53 ( 4 )   312 - 321   2023.4

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    DOI: 10.1111/hepr.13871

  • Combined effect of SDF-1 peptide and angiogenic cues in co-axial PLGA/gelatin fibers for cutaneous wound healing in diabetic rats

    Muhammad Shafiq, Zhengchao Yuan, Muhammad Rafique, Shinichi Aishima, Hou Jing, Liang Yuqing, Hiroyuki Ijima, Shichao Jiang, Xiumei Mo

    Colloids and Surfaces B: Biointerfaces   223   2023.3

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    DOI: 10.1016/j.colsurfb.2023.113140

  • Prevention and Repair of Ultraviolet B-Induced Skin Damage in Hairless Mice via Transdermal Delivery of Growth Factors Immobilized in a Gel-in-Oil Nanoemulsion

    Yi Zhang, Yuuta Inoue, Jannatul Fardous, Ryota Doi, Takahiro Ijima, Toshioh Fujibuchi, Yo Ichi Yamashita, Shinichi Aishima, Hiroyuki Ijima

    ACS Omega   8 ( 10 )   9239 - 9249   2023.3

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    DOI: 10.1021/acsomega.2c07343

  • Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-based Cohort Study

    Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Norifumi Kawada, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

    Clinical Gastroenterology and Hepatology   21 ( 2 )   370 - 379   2023.2

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    DOI: 10.1016/j.cgh.2022.01.002

  • Time to enhancement of breast lesions and normal breast parenchyma in light of menopausal status and menstrual cycle for ultrafast dynamic contrast-enhanced MRI using compressed sensing

    Ken Yamaguchi, Takahiko Nakazono, Ryoko Egashira, Shuichi Fukui, Koichi Baba, Takahiro Hamamoto, Shinichi Aishima, Katsuya Maruyama, Dominik Nickel, Hiroyuki Irie

    Magnetic Resonance Imaging   96   102 - 107   2023.2

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    DOI: 10.1016/j.mri.2022.11.006

  • Validation of Noninvasive Markers for HCC Risk Stratification in 1389 Patients With Biopsy-proven NAFLD

    Hidenori Toyoda, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Norifumi Kawada, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

    Gastro Hep Advances   2 ( 8 )   1093 - 1102   2023.1

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    DOI: 10.1016/j.gastha.2023.07.018

  • ALK rearrangement-associated renal cell carcinoma morphologically mimicking mucinous tubular and spindle cell carcinoma: a case report

    Keita Kai, Shohei Tobu, Shinichi Kido, Shuji Mikami, Kengo Takeuchi, Akito Dobashi, Yuki Togashi, Mitsuru Noguchi, Shinichi Aishima

    Diagnostic Pathology   17 ( 1 )   2022.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13000-022-01238-z

  • Silence of resident microglia in GPI anchorless prion disease and activation of microglia in Gerstmann-Sträussler-Scheinker disease and sporadic Creutzfeldt-Jakob disease

    82 ( 1 )   38 - 48   2022.12

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    GPI anchorless prion diseases (GPIALPs) show numerous coarse prion protein (PrP) deposits in the CNS but neuropil spongiform changes are mild and the incidence of dementia is low. Here, we examined differences in resident microglial phenotypes between GPIALP (D178fs25) and the other prion diseases Gerstmann-Sträussler-Scheinker (GSS) disease and sporadic Creutzfeldt-Jakob disease (sCJD) with respect to homeostasis and activation. Immunohistochemistry was performed on 2 GPIALP (D178fs25), 4 GSS (P102L), and 4 sCJD cases. Homeostatic microglia expressing TMEM119 and P2RY12 were preserved in GPIALP compared to GSS and sCJD. Microglia/macrophage activation in GSS and sCJD was associated with the extent of spongiform change. Immunoelectron microscopy revealed TMEM119 and P2RY12 in PrP plaque cores. Activated microglia/macrophages expressing HLA-DR and CD68 were predominant in GSS and sCJD whereas in GPIALP, homeostatic microglia were retained and activated microglia/macrophages were rarely observed. These data suggest that PrP deposition in GPIALP is less toxic and that microglia may be immune-tolerant to PrP deposition. This may be associated with milder tissue damage and a low incidence of dementia. Whereas microglia/macrophage activation is considered to be a reaction to tissue injury, this study shows that the degree of microglia/macrophage activity might influence the extent of tissue damage.

    DOI: 10.1093/jnen/nlac098

  • Age-dependent effects of diabetes and obesity on liver-related events in non-alcoholic fatty liver disease: Subanalysis of CLIONE in Asia

    Yuya Seko, Miwa Kawanaka, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Takeshi Okanoue, Yoshito Itoh, Atsushi Nakajima

    Journal of Gastroenterology and Hepatology (Australia)   37 ( 12 )   2313 - 2320   2022.12

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    DOI: 10.1111/jgh.16019

  • A Case of Massive Dendriform Ossification Showing Diffuse Interstitial Lung Disease in a Patient with a History of Intensive Occupational Dust Exposure

    Ryoko Egashira, Koichiro Takahashi, Takahiko Nakazono, Ken Yamaguchi, Naofumi Miyahara, Shinichi Aishima, Kenzo Okamoto, Hiroyuki Irie

    Journal of Thoracic Imaging   37 ( 6 )   W106 - W108   2022.11

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    DOI: 10.1097/RTI.0000000000000672

  • Relationship between cellular morphology and abnormality of SWI/SNF complex subunits in pancreatic undifferentiated carcinoma

    Takeo Yamamoto, Kenichi Kohashi, Yutaka Yamada, Jun Kawata, Kukiko Sakihama, Ryota Matsuda, Yutaka Koga, Shinichi Aishima, Masafumi Nakamura, Yoshinao Oda

    Journal of Cancer Research and Clinical Oncology   148 ( 11 )   2945 - 2957   2022.11

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    DOI: 10.1007/s00432-021-03860-8

  • Chronological Changes in the Expression Pattern of Hippocampal Prion Proteins During Disease Progression in Sporadic Creutzfeldt-Jakob Disease MM1 Subtype

    Kaoru Yagita, Hideko Noguchi, Sachiko Koyama, Hideomi Hamasaki, Takashi Komori, Shinichi Aishima, Takayuki Kosaka, Mitsuharu Ueda, Yoshihiro Komohara, Akihiro Watanabe, Naokazu Sasagasako, Toshiharu Ninomiya, Yoshinao Oda, Hiroyuki Honda

    Journal of Neuropathology and Experimental Neurology   81 ( 11 )   900 - 909   2022.11

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    DOI: 10.1093/jnen/nlac078

  • Comparison of long-term prognosis between non-obese and obese patients with non-alcoholic fatty liver disease

    Michihiro Iwaki, Takaomi Kessoku, Kosuke Tanaka, Anna Ozaki, Yuki Kasai, Atsushi Yamamoto, Kota Takahashi, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, Shunsuke Oyamada, Noritoshi Kobayashi, Shinichi Aishima, Satoru Saito, Atsushi Nakajima, Masato Yoneda

    JGH Open   6 ( 10 )   696 - 703   2022.10

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    DOI: 10.1002/jgh3.12808

  • Multimodality Imaging Approach for a Left Ventricular Aneurysm in a Patient With Myocardial Infarction and Non-Obstructive Coronary Arteries

    Goro Yoshioka, Shinjo Sonoda, Shinichi Aishima, Koichi Node

    Circulation Journal   86 ( 10 )   1586   2022.10

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    DOI: 10.1253/circj.CJ-21-1080

  • Diagnostic Categories and Key Features for Pathological Diagnosis of Endoscopic Ultrasound-Guided Fine Needle Aspiration Biopsy Samples of Pancreatic Lesions: A Consensus Study

    Yoshiki Naito, Kenji Notohara, Yuko Omori, Shinichi Aishima, Takao Itoi, Nobuyuki Ohike, Yoshinobu Okabe, Motohiro Kojima, Takuma Tajiri, Mariko Tanaka, Masayuki Tsuneki, Toshio Nakagohri, Tomoko Norose, Kenichi Hirabayashi, Yuki Fukumura, Tomoko Mitsuhashi, Hiroshi Yamaguchi, Noriyoshi Fukushima, Toru Furukawa

    Pancreas   51 ( 9 )   1105 - 1111   2022.10

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    DOI: 10.1097/MPA.0000000000002179

  • Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD Patients

    Yoshihiro Kamada, Hirokazu Takahashi, Yuji Ogawa, Hideyuki Hyogo, Kyoko Nakamura, Tomomi Yada, Norihiko Asada, Tomomi Bando, Hanako Sawano, Mika Hatanaka, Takako Tosa, Mika Ando, Etsuko Hikita, Kaori Yoshida, Masahiro Koseki, Yoshio Sumida, Kazuhisa Maeda, Makoto Fujii, Shinichi Aishima, Mariko Hayakawa, Atsushi Nakajima

    Nutrients   14 ( 17 )   2022.9

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    DOI: 10.3390/nu14173453

  • Pathological Evaluation of Resected Colorectal Liver Metastases: mFOLFOX6 Plus Bevacizumab versus mFOLFOX6 Plus Cetuximab in the Phase II ATOM Trial

    Takao Takahashi, Kazuyuki Ishida, Yasunori Emi, Michiie Sakamoto, Johji Imura, Shinichi Aishima, Kei Muro, Hiroyuki Uetake, Eiji Oki, Yu Katayose, Kazuhiro Yoshida, Michiaki Unno, Ichinosuke Hyodo, Naohiro Tomita, Kenichi Sugihara, Yoshihiko Maehara

    Cancers   14 ( 18 )   2022.9

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    DOI: 10.3390/cancers14184392

  • Substantial improvement of histopathological diagnosis by whole-slide image-based remote consultation

    Shizu Shinohara, Andrey Bychkov, Jijgee Munkhdelger, Kishio Kuroda, Han Seung Yoon, Shota Fujimura, Kazuhiro Tabata, Bungo Furusato, Daisuke Niino, Shinpei Morimoto, Takashi Yao, Tomoo Itoh, Hajime Aoyama, Naoko Tsuyama, Yoshiki Mikami, Toshitaka Nagao, Tohru Ikeda, Noriyoshi Fukushima, Oi Harada, Takako Kiyokawa, Naoki Yoshimi, Shinichi Aishima, Ichiro Maeda, Ichiro Mori, Koji Yamanegi, Koichi Tsuneyama, Ryohei Katoh, Miki Izumi, Yoshinao Oda, Junya Fukuoka

    Virchows Archiv   481 ( 2 )   295 - 305   2022.8

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    DOI: 10.1007/s00428-022-03327-2

  • Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study

    Yuki Kasai, Takaomi Kessoku, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Takashi Kobayashi, Michihiro Iwaki, Anna Ozaki, Asako Nogami, Yasushi Honda, Yuji Ogawa, Shingo Kato, Kento Imajo, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Haruki Usuda, Koichiro Wada, Miwa Kawanaka, Takumi Kawaguchi, Takuji Torimura, Masayoshi Kage, Hideyuki Hyogo, Hirokazu Takahashi, Yuichiro Eguchi, Shinichi Aishima, Noritoshi Kobayashi, Yoshio Sumida, Akira Honda, Shunsuke Oyamada, Satoru Shinoda, Satoru Saito, Atsushi Nakajima

    Clinical and translational gastroenterology   13 ( 7 )   e00503   2022.7

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    DOI: 10.14309/ctg.0000000000000503

  • Efficacy of a newly developed bioabsorbable pancreatic clip for distal pancreatectomy in swine

    Yo ichi Yamashita, Takanobu Yamao, Yosuke Nakao, Tatsunori Miyata, Yasuhiro Ikegami, Soichiro Yamane, Taiga Ito, Taku Furukawa, Jaeyong Cho, Fanqi Wu, Yasumitsu Fujie, Mitsuru Arima, Shinichi Aishima, Hiroyuki Ijima, Hideo Baba

    Surgery Today   52 ( 7 )   1109 - 1114   2022.7

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    DOI: 10.1007/s00595-021-02435-x

  • Influence of liver stiffness heterogeneity on staging fibrosis in patients with nonalcoholic fatty liver disease

    Nobuyoshi Kawamura, Kento Imajo, Kyle J. Kalutkiewicz, Koki Nagai, Michihiro Iwaki, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Takuma Higurashi, Kunihiro Hosono, Hirokazu Takahashi, Masato Yoneda, Satoru Saito, Shinichi Aishima, Hidenori Toyoda, Hideki Hayashi, Yoshio Sumida, Richard L. Ehman, Atsushi Nakajima

    Hepatology   76 ( 1 )   186 - 195   2022.7

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    DOI: 10.1002/hep.32302

  • HSPA8 Single-Nucleotide Polymorphism Is Associated with Serum HSC70 Concentration and Carotid Artery Atherosclerosis in Nonalcoholic Fatty Liver Disease

    Wenli Zhao, Hitoe Mori, Yuki Tomiga, Kenichi Tanaka, Rasheda Perveen, Keiichiro Mine, Chika Inadomi, Wataru Yoshioka, Yoshihito Kubotsu, Hiroshi Isoda, Takuya Kuwashiro, Satoshi Oeda, Takumi Akiyama, Ye Zhao, Iwata Ozaki, Seiho Nagafuchi, Atsushi Kawaguchi, Shinichi Aishima, Keizo Anzai, Hirokazu Takahashi

    Genes   13 ( 7 )   2022.7

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    DOI: 10.3390/genes13071265

  • Cytological Comparison between Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Image Analysis Software Using Touch Smear Samples of Surgically Resected Specimens

    Sho Kitamura, Keita Kai, Mitsuo Nakamura, Tomokazu Tanaka, Takao Ide, Hirokazu Noshiro, Eisaburo Sueoka, Shinich Aishima

    Cancers   14 ( 9 )   2022.5

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    DOI: 10.3390/cancers14092301

  • Direct Comparison of US and MR Elastography for Staging Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

    Kento Imajo, Yasushi Honda, Takashi Kobayashi, Koki Nagai, Anna Ozaki, Michihiro Iwaki, Takaomi Kessoku, Yuji Ogawa, Hirokazu Takahashi, Yusuke Saigusa, Masato Yoneda, Hiroyuki Kirikoshi, Daisuke Utsunomiya, Shinichi Aishima, Satoru Saito, Atsushi Nakajima

    Clinical Gastroenterology and Hepatology   20 ( 4 )   908 - 917.e11   2022.4

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    DOI: 10.1016/j.cgh.2020.12.016

  • Atrial Structural Remodeling in Patients With Atrial Fibrillation Is a Diffuse Fibrotic Process: Evidence From High-Density Voltage Mapping and Atrial Biopsy

    Takanori Yamaguchi, Toyokazu Otsubo, Yuya Takahashi, Kana Nakashima, Akira Fukui, Kei Hirota, Yumi Ishii, Kodai Shinzato, Ryosuke Osako, Mai Tahara, Yuki Kawano, Atsushi Kawaguchi, Shinichi Aishima, Naohiko Takahashi, Koichi Node

    Journal of the American Heart Association   11 ( 6 )   2022.3

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    DOI: 10.1161/JAHA.121.024521

  • Concordance of the histological diagnosis of type 1 autoimmune pancreatitis and its distinction from pancreatic ductal adenocarcinoma with endoscopic ultrasound-guided fine needle biopsy specimens: an interobserver agreement study

    Kenji Notohara, Terumi Kamisawa, Toru Furukawa, Noriyoshi Fukushima, Takeshi Uehara, Satomi Kasashima, Eisuke Iwasaki, Atsushi Kanno, Atsuhiro Kawashima, Kensuke Kubota, Yasuhiro Kuraishi, Masayo Motoya, Itaru Naitoh, Takayoshi Nishino, Junichi Sakagami, Kyoko Shimizu, Teruko Tomono, Shinichi Aishima, Yuki Fukumura, Kenichi Hirabayashi, Motohiro Kojima, Tomoko Mitsuhashi, Yoshiki Naito, Nobuyuki Ohike, Takuma Tajiri, Hiroshi Yamaguchi, Hideyo Fujiwara, Emi Ibuki, Shota Kobayashi, Masashi Miyaoka, Mamiko Nagase, Junko Nakashima, Masamichi Nakayama, Shinsuke Oda, Daiki Taniyama, Sho Tsuyama, Syunsuke Watanabe, Tsukasa Ikeura, Shigeyuki Kawa, Kazuichi Okazaki

    Virchows Archiv   480 ( 3 )   565 - 575   2022.3

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    DOI: 10.1007/s00428-021-03236-w

  • Ipragliflozin Improves the Hepatic Outcomes of Patients With Diabetes with NAFLD

    Hirokazu Takahashi, Takaomi Kessoku, Miwa Kawanaka, Michihiro Nonaka, Hideyuki Hyogo, Hideki Fujii, Tomoaki Nakajima, Kento Imajo, Kenichi Tanaka, Yoshihito Kubotsu, Hiroshi Isoda, Satoshi Oeda, Osamu Kurai, Masato Yoneda, Masafumi Ono, Yoichiro Kitajima, Ryo Tajiri, Ayako Takamori, Atsushi Kawaguchi, Shinichi Aishima, Masayoshi Kage, Atsushi Nakajima, Yuichiro Eguchi, Keizo Anzai

    Hepatology Communications   6 ( 1 )   120 - 132   2022.1

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    DOI: 10.1002/hep4.1696

  • Predictive value of cytokeratin-18 fragment levels for diagnosing steatohepatitis in patients with nonalcoholic fatty liver disease. International journal

    Toshifumi Tada, Toshiji Saibara, Masafumi Ono, Hirokazu Takahashi, Yuichiro Eguchi, Hideyuki Hyogo, Miwa Kawanaka, Takashi Kumada, Hidenori Toyoda, Satoshi Yasuda, Atsushi Nakajima, Masato Yoneda, Saiyu Tanaka, Keiji Shimada, Hideaki Hoshino, Shinichi Aishima, Masayoshi Kage, Yoshio Sumida

    European journal of gastroenterology & hepatology   33 ( 11 )   1451 - 1458   2021.11

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    DOI: 10.1097/MEG.0000000000002176

  • Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis. International journal

    Dolgormaa Gantumur, Norifumi Harimoto, Ryo Muranushi, Kouki Hoshino, Chingun Batbayar, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Takehiko Yokobori, Shinichi Aishima, Ken Shirabe

    Hepatology research : the official journal of the Japan Society of Hepatology   51 ( 10 )   1058 - 1063   2021.10

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    DOI: 10.1111/hepr.13648

  • Intracranial Mönckeberg's Atherosclerosis Is Frequently Found in Autopsy Cases of Advanced Stage Malignancy with Cerebral Infarction. International journal

    13 ( 20 )   2021.10

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    Cerebral infarction (CI) severely affects the prognosis of patients with malignancy. The aim of the study was to compare the pathology of CI between cases with and without malignancy focusing on intracranial Mönckeberg's atherosclerosis. Among 778 autopsy cases of craniotomy, 53 cases of "cerebral infarction without malignancy group" (CI group), 50 cases of "malignant tumor without CI group" (MT group), and 39 cases of "cerebral infarction with malignancy group" (CM group) were identified. Mönckeberg's atherosclerosis was mainly found in the basal ganglia and its prevalence in the CM group (38.5%) was significantly higher than in the MT group (12.0%, p = 0.005), and apparently higher than in the CI group (18.9%, p = 0.057). The CI group was significantly older, had higher BMIs, and a greater prevalence of hypertension and atrial fibrillation compared to the CM group. In addition, the prevalence of chronic renal disease was significantly lower in the CM group (2.6%, p = 0.012) than in the CI group (20.8%). Our results indicated that Mönckeberg's atherosclerosis was often found in the basal ganglia of CM cases and that intracranial Mönckeberg's atherosclerosis is a potential risk factor for CI in patients with advanced stage malignancy.

    DOI: 10.3390/cancers13205234

  • Effect of skin-capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease. International journal

    Syunichiro Kimura, Kenichi Tanaka, Satoshi Oeda, Kaori Inoue, Chika Inadomi, Yoshihito Kubotsu, Wataru Yoshioka, Michiaki Okada, Hiroshi Isoda, Takuya Kuwashiro, Takumi Akiyama, Aya Kurashige, Ayaka Oshima, Mayumi Oshima, Yasue Matsumoto, Atsushi Kawaguchi, Keizo Anzai, Eisaburo Sueoka, Shinichi Aishima, Hirokazu Takahashi

    Scientific reports   11 ( 1 )   15641 - 15641   2021.8

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    DOI: 10.1038/s41598-021-94970-3

  • Prognostic implications of the coexisting precursor lesion types in invasive gallbladder cancer. International journal

    Naoki Mochidome, Yutaka Koga, Yoshihiro Ohishi, Tetsuyuki Miyazaki, Ryota Matsuda, Yuichi Yamada, Shinichi Aishima, Masafumi Nakamura, Yoshinao Oda

    Human pathology   114   44 - 53   2021.8

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    DOI: 10.1016/j.humpath.2021.05.001

  • Infiltration of CD1a-positive dendritic cells in advanced laryngeal cancer correlates with unfavorable outcomes post-laryngectomy. International journal

    Akimichi Minesaki, Keita Kai, Yuichiro Kuratomi, Shinichi Aishima

    BMC cancer   21 ( 1 )   973 - 973   2021.8

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    DOI: 10.1186/s12885-021-08715-6

  • Gut microbiota composition associated with hepatic fibrosis in non-obese patients with non-alcoholic fatty liver disease. International journal

    Michihiro Iwaki, Takaomi Kessoku, Anna Ozaki, Yuki Kasai, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, Masato Yoneda, Ayako Maeda, Yoshiki Tanaka, Shunji Nakajima, Hiroshi Ohno, Haruki Usuda, Miwa Kawanaka, Takumi Kawaguchi, Takuji Torimura, Masayoshi Kage, Hideyuki Hyogo, Hirokazu Takahashi, Yuichiro Eguchi, Shinichi Aishima, Koichiro Wada, Noritoshi Kobayashi, Yoshio Sumida, Satoru Saito, Atsushi Nakajima

    Journal of gastroenterology and hepatology   36 ( 8 )   2275 - 2284   2021.8

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    DOI: 10.1111/jgh.15487

  • A deep learning model to detect pancreatic ductal adenocarcinoma on endoscopic ultrasound-guided fine-needle biopsy. International journal

    Yoshiki Naito, Masayuki Tsuneki, Noriyoshi Fukushima, Yutaka Koga, Michiyo Higashi, Kenji Notohara, Shinichi Aishima, Nobuyuki Ohike, Takuma Tajiri, Hiroshi Yamaguchi, Yuki Fukumura, Motohiro Kojima, Kenichi Hirabayashi, Yoshihiro Hamada, Tomoko Norose, Keita Kai, Yuko Omori, Aoi Sukeda, Hirotsugu Noguchi, Kaori Uchino, Junya Itakura, Yoshinobu Okabe, Yuichi Yamada, Jun Akiba, Fahdi Kanavati, Yoshinao Oda, Toru Furukawa, Hirohisa Yano

    Scientific reports   11 ( 1 )   8454 - 8454   2021.4

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    DOI: 10.1038/s41598-021-87748-0

  • Unclassified hepatocellular adenoma with beta-catenin mutation: a case report. International journal

    Ryo Muranushi, Kenichiro Araki, Norifumi Harimoto, Takehiko Yokobori, Kouki Hoshino, Kei Hagiwara, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Shinichi Aishima, Ken Shirabe

    Surgical case reports   7 ( 1 )   46 - 46   2021.2

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    DOI: 10.1186/s40792-021-01131-9

  • Exploiting synergistic effect of externally loaded bFGF and endogenous growth factors for accelerated wound healing using heparin functionalized PCL/gelatin co-spun nanofibrous patches

    Akshat Joshi, Zhe Xu, Yasuhiro Ikegami, Kozue Yoshida, Yusuke Sakai, Akshay Joshi, Tejinder Kaur, Yosuke Nakao, Yo ichi Yamashita, Hideo Baba, Shinichi Aishima, Neetu Singh, Hiroyuki Ijima

    Chemical Engineering Journal   404   2021.1

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    DOI: 10.1016/j.cej.2020.126518

  • Immunohistochemical analysis of the aggregation of CD1a-positive dendritic cells in resected specimens and its association with surgical outcomes for patients with gallbladder cancer. International journal

    Keita Kai, Tomokazu Tanaka, Takao Ide, Atsushi Kawaguchi, Hirokazu Noshiro, Shinichi Aishima

    Translational oncology   14 ( 1 )   100923 - 100923   2021.1

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    DOI: 10.1016/j.tranon.2020.100923

  • Decrease in fasting insulin secretory function correlates with significant liver fibrosis in Japanese non-alcoholic fatty liver disease patients. International journal

    Norimasa Araki, Hirokazu Takahashi, Ayako Takamori, Yoichiro Kitajima, Hideyuki Hyogo, Yoshio Sumida, Saiyu Tanaka, Keizo Anzai, Shinichi Aishima, Kazuaki Chayama, Kazuma Fujimoto, Yuichiro Eguchi

    JGH open : an open access journal of gastroenterology and hepatology   4 ( 5 )   929 - 936   2020.10

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    DOI: 10.1002/jgh3.12367

  • Histopathological findings of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

    Masayoshi Kage, Shinichi Aishima, Hironori Kusano, Hirohisa Yano

    Journal of medical ultrasonics (2001)   47 ( 4 )   549 - 554   2020.10

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    DOI: 10.1007/s10396-020-01061-3

  • Guidance for diagnosing autoimmune pancreatitis with biopsy tissues. International journal

    Kenji Notohara, Terumi Kamisawa, Noriyoshi Fukushima, Toru Furukawa, Takuma Tajiri, Hiroshi Yamaguchi, Shinichi Aishima, Yuki Fukumura, Kenichi Hirabayashi, Eisuke Iwasaki, Atsushi Kanno, Satomi Kasashima, Atsuhiro Kawashima, Motohiro Kojima, Kensuke Kubota, Yasuhiro Kuraishi, Tomoko Mitsuhashi, Yoshiki Naito, Itaru Naitoh, Hiroshi Nakase, Takayoshi Nishino, Nobuyuki Ohike, Junichi Sakagami, Kyoko Shimizu, Masahiro Shiokawa, Takeshi Uehara, Tsukasa Ikeura, Shigeyuki Kawa, Kazuichi Okazaki

    Pathology international   70 ( 10 )   699 - 711   2020.10

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    DOI: 10.1111/pin.12994

  • Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study. International journal

    Yuji Ogawa, Takashi Kobayashi, Yasushi Honda, Takaomi Kessoku, Wataru Tomeno, Kento Imajo, Takashi Nakahara, Satoshi Oeda, Yuko Nagaoki, Yuichiro Amano, Tatsuya Ando, Megumi Hirayama, Osamu Isono, Hidenori Kamiguchi, Hiroshi Nagabukuro, Shinji Ogawa, Yoshinori Satomi, Yusuke Saigusa, Hirokazu Takahashi, Hideyuki Hyogo, Masato Yoneda, Satoru Saito, Takeharu Yamanaka, Shinichi Aishima, Yuichiro Eguchi, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakajima

    Hepatology research : the official journal of the Japan Society of Hepatology   50 ( 8 )   955 - 965   2020.8

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    DOI: 10.1111/hepr.13528

  • Clinicopathological characteristics of combined hepatocellular cholangiocarcinoma from the viewpoint of patient prognosis after hepatic resection: High rate of early recurrence and its predictors. International journal

    Yo-Ichi Yamashita, Shinichi Aishima, Yosuke Nakao, Tomoharu Yoshizumi, Hiroaki Nagano, Tamotsu Kuroki, Yuko Takami, Takao Ide, Masayuki Ohta, Mitsuhisa Takatsuki, Atsushi Nanashima, Fuminori Ishii, Kenji Kitahara, Satoshi Iino, Toru Beppu, Hideo Baba, Susumu Eguchi

    Hepatology research : the official journal of the Japan Society of Hepatology   50 ( 7 )   863 - 870   2020.7

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    DOI: 10.1111/hepr.13507

  • Diagnostic accuracy of FibroScan-AST score to identify non-alcoholic steatohepatitis with significant activity and fibrosis in Japanese patients with non-alcoholic fatty liver disease: Comparison between M and XL probes. International journal

    Satoshi Oeda, Hirokazu Takahashi, Kento Imajo, Yuya Seko, Takashi Kobayashi, Yuji Ogawa, Michihisa Moriguchi, Masato Yoneda, Keizo Anzai, Hiroyuki Irie, Eisaburo Sueoka, Shinichi Aishima, Masayoshi Kage, Yoshito Itoh, Yuichiro Eguchi, Atsushi Nakajima

    Hepatology research : the official journal of the Japan Society of Hepatology   50 ( 7 )   831 - 839   2020.7

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    DOI: 10.1111/hepr.13508

  • Accuracy of the Enhanced Liver Fibrosis test, and combination of the Enhanced Liver Fibrosis and non-invasive tests for the diagnosis of advanced liver fibrosis in patients with non-alcoholic fatty liver disease. International journal

    Chika Inadomi, Hirokazu Takahashi, Yuji Ogawa, Satoshi Oeda, Kento Imajo, Yoshihito Kubotsu, Kenichi Tanaka, Takaomi Kessoku, Michiaki Okada, Hiroshi Isoda, Takumi Akiyama, Hideaki Fukushima, Masato Yoneda, Keizo Anzai, Shinichi Aishima, Atsushi Nakajima, Yuichiro Eguchi

    Hepatology research : the official journal of the Japan Society of Hepatology   50 ( 6 )   682 - 692   2020.6

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    DOI: 10.1111/hepr.13495

  • Discordant pathological diagnosis of non-alcoholic fatty liver disease: A prospective multicenter study. International journal

    Takuya Kuwashiro, Hirokazu Takahashi, Hideyuki Hyogo, Yuji Ogawa, Kento Imajo, Masato Yoneda, Takashi Nakahara, Satoshi Oeda, Kenichi Tanaka, Yuichiro Amano, Shinji Ogawa, Atsushi Kawaguchi, Shinichi Aishima, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakajima, Yuichiro Eguchi

    JGH open : an open access journal of gastroenterology and hepatology   4 ( 3 )   497 - 502   2020.6

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    DOI: 10.1002/jgh3.12289

  • Unclassified hepatocellular adenoma with histological brown pigment deposition and serum PIVKA-II level elevation: a case report. International journal

    Kouki Hoshino, Norifumi Harimoto, Ryo Muranushi, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Ran Tomomasa, Sumihito Nobusawa, Shinichi Aishima, Osamu Nakashima, Ken Shirabe

    Surgical case reports   6 ( 1 )   94 - 94   2020.5

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    DOI: 10.1186/s40792-020-00853-6

  • Accumulation of Astrocytic Aquaporin 4 and Aquaporin 1 in Prion Protein Plaques. International journal

    Shoko Sadashima, Hiroyuki Honda, Satoshi O Suzuki, Masahiro Shijo, Shinichi Aishima, Keita Kai, Junichi Kira, Toru Iwaki

    Journal of neuropathology and experimental neurology   79 ( 4 )   419 - 429   2020.4

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    DOI: 10.1093/jnen/nlaa010

  • Accuracy of liver stiffness measurement and controlled attenuation parameter using FibroScan® M/XL probes to diagnose liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease: a multicenter prospective study.

    55 ( 4 )   428 - 440   2020.4

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    BACKGROUND: Few studies have evaluated both liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease (NAFLD) using both FibroScan® M and XL probes. This study was performed to investigate the accuracy of both FibroScan® probes to diagnose liver fibrosis and steatosis in patients with NAFLD. METHODS: We prospectively enrolled 137 consecutive patients with clinically suspected NAFLD in our joint-research facilities. Liver biopsies, liver stiffness measurements (LSMs), and controlled attenuation parameter (CAP) measurements were performed, and 122 patients with NAFLD diagnosed pathologically by central pathologists were included in the final analysis. RESULTS: Reliable LSM results were obtained in 85.2% (M) and 89.3% (XL) of patients, and CAP was reliable in 90.2% (M) and 90.2% (XL). The median LSM was significantly lower with the XL than M probe, and CAP was significantly higher with the XL than M probe. The optimal cut-off values for diagnosing the fibrosis stage were lower for LSM with the XL than M probe (stage ≥ 2, 6.7 vs. 7.0; stage ≥ 3, 8.2 vs. 10.8; stage 4, 14.3 vs. 16.8, respectively), whereas those of CAP were higher for the XL than M probe (score of ≥ 2, 273 vs. 267; score of 3, 302 vs. 286, respectively). There were no significant differences in accuracy of the LSM and CAP between the probes. CONCLUSIONS: Liver fibrosis and steatosis could be equally evaluated with FibroScan® M and XL probes in patients with NAFLD. There was no significant difference in diagnostic accuracy between the two probes using probe-specific cut-off values.

    DOI: 10.1007/s00535-019-01635-0

  • Decreased cytokeratin 7 expression correlates with the progression of cervical squamous cell carcinoma and poor patient outcomes. International journal

    Mariko Hashiguchi, Masanori Masuda, Keita Kai, Yoshifumi Nakao, Atsushi Kawaguchi, Masatoshi Yokoyama, Shinichi Aishima

    The journal of obstetrics and gynaecology research   45 ( 11 )   2228 - 2236   2019.11

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    DOI: 10.1111/jog.14108

  • Fairly rare small-diameter hepatocellular carcinoma with right adrenal gland metastasis having an inferior vena cava tumor thrombus: a case report. International journal

    Takamichi Igarashi, Norifumi Harimoto, Nozomi Matsumura, Masaya Sugiyama, Kenichiro Araki, Takehiko Yokobori, Takashi Kosone, Hitoshi Takagi, Shinichi Aishima, Hideaki Yokoo, Ken Shirabe

    Surgical case reports   5 ( 1 )   170 - 170   2019.11

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    DOI: 10.1186/s40792-019-0705-7

  • A unique autopsy case of ascending aortic dissection caused by giant cell arteritis without drug therapy. International journal

    Yukari Takase, Yosuke Murakami, Jumpei Nishi, Osamu Tokunaga, Toshiharu Matsumoto, Shinichi Aishima

    Pathology international   69 ( 10 )   614 - 618   2019.10

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    DOI: 10.1111/pin.12845

  • Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases. International journal

    Hiroyuki Honda, Masaki Matsumoto, Masahiro Shijo, Hideomi Hamasaki, Shoko Sadashima, Satoshi O Suzuki, Shinichi Aishima, Keita Kai, Keiichi I Nakayama, Naokazu Sasagasako, Toru Iwaki

    Journal of neuropathology and experimental neurology   78 ( 10 )   922 - 929   2019.10

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    DOI: 10.1093/jnen/nlz075

  • CXCL12 expression in intrahepatic cholangiocarcinoma is associated with metastasis and poor prognosis. International journal

    Tatsunori Miyata, Yo-Ichi Yamashita, Tomoharu Yoshizumi, Masayuki Shiraishi, Masayuki Ohta, Susumu Eguchi, Shinichi Aishima, Hikaru Fujioka, Hideo Baba

    Cancer science   110 ( 10 )   3197 - 3203   2019.10

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    DOI: 10.1111/cas.14151

  • IFN-γ Promotes Epithelial-Mesenchymal Transition and the Expression of PD-L1 in Pancreatic Cancer. International journal

    240   115 - 123   2019.8

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    BACKGROUND: Tumor immune reactions not only provide host defense but also accelerate tumor immune escape and phenotype switching. Here, we examined the association of programmed cell death ligand 1 (PD-L1) expression with epithelial-mesenchymal transition (EMT)-associated markers in pancreatic ductal adenocarcinoma (PDA) within the context of the tumor microenvironment. MATERIALS AND METHODS: PDA samples from 36 patients were analyzed for PD-L1, vimentin, E-cadherin, and Snail expressions and for PDA cell and immune cell infiltration. PD-L1 expression and EMT in PDA cell lines under conditions of altering interferon gamma (IFN-γ) signals were also assessed. RESULTS: Immunohistochemistry revealed a significant correlation between vimentin and PD-L1 expression, whereas double staining showed them to be simultaneously expressed by PDA cells. Positive vimentin expression was associated with the infiltration of a lower number of CD8+ T cells and a higher number of FoxP3+ cells and poor patient prognosis (P = 0.03). PDA tumor cells promoted PD-L1 expression and EMT under the presence of IFN-γ, which was inhibited by the signal transducer and activator of transcription (STAT)1 small interfering RNA. CONCLUSIONS: Strong correlations were observed between PD-L1 expression, EMT, and the immunosuppressive tumor microenvironment. Targeting STAT1 combined with PD-1/PD-L1 immunotherapy may improve outcomes for patients with PDA.

    DOI: 10.1016/j.jss.2019.02.038

  • Primary mucoepidermoid carcinoma of the liver with CRTC1-MAML2 fusion: a case report. International journal

    Jiro Watanabe, Keita Kai, Ken Tanikawa, Mamoru Hiraki, Naohisa Mizukami, Shinichi Aishima, Takafumi Nakano, Hidetaka Yamamoto

    Diagnostic pathology   14 ( 1 )   84 - 84   2019.7

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    DOI: 10.1186/s13000-019-0863-8

  • Transferrin receptor 1 overexpression is associated with tumour de-differentiation and acts as a potential prognostic indicator of hepatocellular carcinoma. International journal

    Makiko Adachi, Keita Kai, Koutaro Yamaji, Takao Ide, Hirokazu Noshiro, Atsushi Kawaguchi, Shinichi Aishima

    Histopathology   75 ( 1 )   63 - 73   2019.7

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    DOI: 10.1111/his.13847

  • External validation of ADNEX MR SCORING system: a single-centre retrospective study

    K. Sasaguri, K. Yamaguchi, T. Nakazono, M. Mizuguchi, S. Aishima, M. Yokoyama, H. Irie

    Clinical Radiology   74 ( 2 )   131 - 139   2019.2

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    DOI: 10.1016/j.crad.2018.10.014

  • Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation. International journal

    Keiichiro Okuyama, Yoshihiko Kitajima, Noriyuki Egawa, Hiroshi Kitagawa, Kotaro Ito, Shinichi Aishima, Kazuyoshi Yanagihara, Tomokazu Tanaka, Hirokazu Noshiro

    Scientific reports   9 ( 1 )   2822 - 2822   2019.2

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    DOI: 10.1038/s41598-019-39563-x

  • Formalin fixation on HER-2 and PD-L1 expression in gastric cancer: A pilot analysis using the same surgical specimens with different fixation times. International journal

    Keita Kai, Yukie Yoda, Atsushi Kawaguchi, Akimichi Minesaki, Hironori Iwasaki, Shinichi Aishima, Hirokazu Noshiro

    World journal of clinical cases   7 ( 4 )   419 - 430   2019.2

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    DOI: 10.12998/wjcc.v7.i4.419

  • Occult HBV infection status and its impact on surgical outcomes in patients with curative resection for HCV-associated hepatocellular carcinoma. International journal

    Koutaro Yamaji, Keita Kai, Sho Komukai, Hiroki Koga, Takao Ide, Atsushi Kawaguchi, Hirokazu Noshiro, Shinichi Aishima

    Hepatobiliary surgery and nutrition   7 ( 6 )   443 - 453   2018.12

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    DOI: 10.21037/hbsn.2018.10.01

  • Primary intrahepatic cholangiocarcinoma with sarcomatous stroma: case report and review of the literature. International journal

    Kyohei Yugawa, Tomoharu Yoshizumi, Yohei Mano, Noboru Harada, Shinji Itoh, Toru Ikegami, Yuji Soejima, Nobuhiro Fujita, Kenichi Kohashi, Shinichi Aishima, Yoshinao Oda, Masaki Mori

    Surgical case reports   4 ( 1 )   138 - 138   2018.11

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    DOI: 10.1186/s40792-018-0543-z

  • Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide. International journal

    Toshihiko Ando, Kensuke Kojima, Haruhiko Sano, Keisuke Kidoguchi, Kana Kusaba, Mariko Yoshimura, Masako Yokoo, Yasushi Kubota, Hideaki Nakamura, Yukari Takase, Shinichi Aishima, Shinya Kimura

    Leukemia & lymphoma   59 ( 10 )   2474 - 2477   2018.10

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    DOI: 10.1080/10428194.2018.1427859

  • A case report of intracholecystic papillary neoplasm of the gallbladder resembling a submucosal tumor. International journal

    Ryo Muranushi, Hideyuki Saito, Asuka Matsumoto, Toshihide Kato, Naritaka Tanaka, Kenji Nakazato, Nobuhiro Morinaga, Yoshinori Shitara, Masatoshi Ishizaki, Takatomo Yoshida, Shinichi Aishima, Ken Shirabe

    Surgical case reports   4 ( 1 )   124 - 124   2018.9

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    DOI: 10.1186/s40792-018-0524-2

  • A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. International journal

    Takayuki Fujii, Ryo Yamasaki, Kyoko Iinuma, Daisuke Tsuchimoto, Yoshinori Hayashi, Ban-Yu Saitoh, Takuya Matsushita, Mizuho A Kido, Shinichi Aishima, Hiroshi Nakanishi, Yusaku Nakabeppu, Jun-Ichi Kira

    Annals of neurology   84 ( 2 )   208 - 224   2018.8

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    DOI: 10.1002/ana.25279

  • Synchronous mantle cell lymphoma and lung adenocarcinoma presenting in a pleural effusion: A rare tumour combination and a potential pitfall of cytodiagnosis

    K. Kai, Y. Ryu, K. Kamochi, A. Nishioka, Y. Kubota, M. Nakamura, S. Kimura, E. Sueoka, S. Aishima

    Cytopathology   29 ( 4 )   400 - 402   2018.8

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    DOI: 10.1111/cyt.12532

  • Neuroendocrine tumor of the pancreas with rhabdoid feature. International journal

    Tetsuyuki Miyazaki, Shinichi Aishima, Minoru Fujino, Keigo Ozono, Yuichiro Kubo, Yasuhiro Ushijima, Takashi Osoegawa, Eikichi Ihara, Itou Tetsuhide, Takao Ohtsuka, Masafumi Nakamura, Yoshinao Oda

    Virchows Archiv : an international journal of pathology   473 ( 2 )   247 - 252   2018.8

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    DOI: 10.1007/s00428-018-2398-x

  • Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. International journal

    Yoshihiro Aiba, Kenichi Harada, Masahiro Ito, Takashi Suematsu, Shinichi Aishima, Yuki Hitomi, Nao Nishida, Minae Kawashima, Mitsuhisa Takatsuki, Susumu Eguchi, Shinji Shimoda, Hitomi Nakamura, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Kiyoshi Migita, Hiroshi Yatsuhashi, Katsushi Tokunaga, Minoru Nakamura

    Scientific reports   8 ( 1 )   11808 - 11808   2018.8

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    DOI: 10.1038/s41598-018-30146-w

  • Fairly rare clear cell adenocarcinoma mimicking liver cancer: a case report. International journal

    Norifumi Harimoto, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichirou Araki, Hayato Ikota, Masafumi Suyama, Takeshi Maki, Shinichi Aishima, Hiroyuki Kuwano, Ken Shirabe

    Surgical case reports   4 ( 1 )   97 - 97   2018.8

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    DOI: 10.1186/s40792-018-0500-x

  • cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation. International journal

    Elizabeth Brunt, Shinichi Aishima, Pierre-Alain Clavien, Kathryn Fowler, Zachary Goodman, Gregory Gores, Annette Gouw, Alex Kagen, David Klimstra, Mina Komuta, Fukuo Kondo, Rebecca Miksad, Masayuki Nakano, Yasuni Nakanuma, Irene Ng, Valerie Paradis, Young Nyun Park, Alberto Quaglia, Massimo Roncalli, Tania Roskams, Michiie Sakamoto, Romil Saxena, Christine Sempoux, Claude Sirlin, Ashley Stueck, Swan Thung, W M S Tsui, Xin-Wei Wang, Aileen Wee, Hirohisa Yano, Matthew Yeh, Yoh Zen, Jessica Zucman-Rossi, Neil Theise

    Hepatology (Baltimore, Md.)   68 ( 1 )   113 - 126   2018.7

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    DOI: 10.1002/hep.29789

  • Microvascular invasion of single small hepatocellular carcinoma ≤3 cm: Predictors and optimal treatments.

    2 ( 3 )   197 - 203   2018.5

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    BACKGROUND: Small hepatocellular carcinomas (HCC ≤3 cm) are generally considered to have low malignant potential; however, some of them display pathological microvascular invasion (MVI). METHODS: Between 1991 and 2013, 414 patients with a single HCC ≤3 cm underwent curative hepatic resection (HR). Predictors for MVI were identified. Using another cohort (149 patients during 2000-2014), our predictors for MVI in HCC ≤3 cm were validated. In 428 patients with a single HCC ≤3 cm who had predictors for MVI, survival was compared among anatomical HR (n = 149), partial HR (n = 227), and radiofrequency ablation (RFA) (n = 52). RESULTS: The positive rate of MVI reached 40.6% (168/414 patients). Independent predictors for MVI were as follows: tumor diameter ≥2 cm (odds ratio 1.84, P = .0052), alpha-fetoprotein (AFP) ≥200 ng/mL (odds ratio 1.82, P = .0466), and des-gamma-carboxy prothrombin (DCP) ≥40 mAU/mL (odds ratio 1.79, P = .0126). Matching at least one predictor among these three could predict MVI in HCC ≤3 cm well (sensitivity 82.8%, positive predictive value [PPV] 48.7%). This criterion could also predict MVI in HCC ≤3 cm well in another cohort (sensitivity 82.8%, PPV 30.3%). In patients with single HCC ≤3 cm matching our criterion for predicting MVI, anatomical HR led to significantly better survival in both disease-free (hazard ratio 0.689, P = .0231) and overall (hazard ratio 0.589, P = .0316) survivals. CONCLUSION: Matching at least one factor among three (tumor diameter ≥2 cm, AFP ≥200 ng/mL, or DCP ≥40 mAU/mL) can predict MVI in HCC ≤3 cm. In such patients, anatomical HR would be recommended to improve survival.

    DOI: 10.1002/ags3.12057

  • Resected primary mucinous cholangiocarcinoma of the liver. International journal

    Kei Hagiwara, Kenichiro Araki, Takahiro Yamanaka, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Norifumi Harimoto, Hiroyuki Kuwano, Sumito Nobusawa, Shinichi Aishima, Ken Shirabe

    Surgical case reports   4 ( 1 )   41 - 41   2018.5

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    DOI: 10.1186/s40792-018-0450-3

  • A dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features. International journal

    Keita Kai, Kazuma Udo, Ken Yamaguchi, Shohei Tobu, Mitsuru Noguchi, Shinichi Aishima

    Pathology international   68 ( 4 )   262 - 264   2018.4

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    DOI: 10.1111/pin.12645

  • Clear Cell Carcinoma of the Uterine Cervix Presented as a Submucosal Tumor Arising in a Background of Cervical Endometriosis. International journal

    Mariko Hashiguchi, Keita Kai, Satoshi Nishiyama, Yoshifumi Nakao, Masatoshi Yokoyama, Shinichi Aishima

    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists   37 ( 1 )   88 - 92   2018.1

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    DOI: 10.1097/PGP.0000000000000386

  • Correlation between smoking habit and surgical outcomes on viral-associated hepatocellular carcinomas. International journal

    Keita Kai, Sho Komukai, Hiroki Koga, Koutaro Yamaji, Takao Ide, Atsushi Kawaguchi, Shinichi Aishima, Hirokazu Noshiro

    World journal of gastroenterology   24 ( 1 )   58 - 68   2018.1

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    DOI: 10.3748/wjg.v24.i1.58

  • Immunoserological and histological differences between autoimmune hepatitis with acute presentation and chronic autoimmune hepatitis. International journal

    Kazufumi Dohmen, Hirofumi Tanaka, Masatora Haruno, Shinichi Aishima

    Hepatology research : the official journal of the Japan Society of Hepatology   47 ( 13 )   1375 - 1382   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.12875

  • Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma. International journal

    Hiroki Koga, Keita Kai, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro

    World journal of hepatology   9 ( 35 )   1286 - 1295   2017.12

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    DOI: 10.4254/wjh.v9.i35.1286

  • Colonic poorly differentiated adenocarcinoma with abundant cancer-associated fibroblasts diagnosed by trans-gastric endoscopic ultrasound-guided fine needle aspiration cytology

    M. Yamasaki, K. Kai, A. Nomura, H. Kono, H. Kawakubo, Y. Sakata, M. Mizuguchi, S. Aishima

    Cytopathology   28 ( 5 )   442 - 444   2017.10

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    DOI: 10.1111/cyt.12443

  • Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis. International journal

    Kota Wakiyama, Yoshihiko Kitajima, Tomokazu Tanaka, Masao Kaneki, Kazuyoshi Yanagihara, Shinichi Aishima, Jun Nakamura, Hirokazu Noshiro

    Scientific reports   7 ( 1 )   12653 - 12653   2017.10

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    DOI: 10.1038/s41598-017-12929-9

  • Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report. International journal

    Norihiro Ishii, Kenichiro Araki, Takahiro Yamanaka, Tadashi Handa, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Shinichi Aishima, Hiroyuki Kuwano, Ken Shirabe

    Surgical case reports   3 ( 1 )   103 - 103   2017.9

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    DOI: 10.1186/s40792-017-0377-0

  • Autopsy case of systemic EBV-positive T-cell lymphoma of childhood with marked hepatomegaly in a middle-aged man. International journal

    Keita Kai, Futa Koga, Norimasa Araki, Takero Shindo, Yuichiro Eguchi, Shuji Toda, Shinichi Aishima

    Pathology international   67 ( 8 )   431 - 433   2017.8

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    DOI: 10.1111/pin.12549

  • SLC2A1/GLUT1 expression in mural nodules of intraductal papillary mucinous neoplasm of the pancreas. International journal

    Yasunori Oda, Shinichi Aishima, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Tetsuyuki Miyazaki, Masao Tanaka, Yoshinao Oda

    Human pathology   65   71 - 78   2017.7

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    DOI: 10.1016/j.humpath.2017.03.008

  • The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer. International journal

    Daisuke Imai, Tomoharu Yoshizumi, Shinji Okano, Hideaki Uchiyama, Toru Ikegami, Norifumi Harimoto, Shinji Itoh, Yuji Soejima, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara

    Cancer medicine   6 ( 7 )   1614 - 1626   2017.7

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    DOI: 10.1002/cam4.1087

  • Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma. International journal

    Huanlin Wang, Kenichi Kohashi, Tomoharu Yoshizumi, Yukihiko Okumura, Yuki Tanaka, Masahiro Shimokawa, Takeshi Iwasaki, Shinichi Aishima, Yoshihiko Maehara, Yoshinao Oda

    Human pathology   64   69 - 75   2017.6

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    DOI: 10.1016/j.humpath.2017.03.007

  • Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma. International journal

    Yoshiki Asayama, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Nobuhiro Fujita, Takao Ohtsuka, Tomoharu Yoshizumi, Shinichi Aishima, Yoshinao Oda, Hiroshi Honda

    European radiology   27 ( 6 )   2563 - 2569   2017.6

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    DOI: 10.1007/s00330-016-4621-y

  • Pathology of intrahepatic cholangiocarcinoma: Peripheral and perihilar type

    Shinichi Aishima

    Pathology of the Bile Duct   149 - 161   2017.5

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    DOI: 10.1007/978-981-10-3500-5_12

  • Hepatobiliary and Pancreatic: Hepatocellular carcinoma developed with angiomyolipoma

    T. Miyata, Y. Yamashita, T. Yamao, N. Umezaki, M. Tsukamoto, Y. Kitano, K. Yamamura, K. Arima, T. Kaida, S. Nakagawa, K. Imai, D. Hashimoto, A. Chikamoto, T. Ishiko, T. Asato, Y. Mikami, S. Aishima, H. Baba

    Journal of Gastroenterology and Hepatology (Australia)   32 ( 3 )   547   2017.3

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    DOI: 10.1111/jgh.13655

  • Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma. International journal

    Keita Kai, Hiroki Koga, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro

    World journal of gastroenterology   23 ( 8 )   1397 - 1405   2017.2

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    DOI: 10.3748/wjg.v23.i8.1397

  • Mass-forming intrahepatic cholangiocarcinoma: Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings. International journal

    Nobuhiro Fujita, Yoshiki Asayama, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Koichiro Moirta, Ken Shirabe, Shinichi Aishima, Huanlin Wang, Yoshinao Oda, Hiroshi Honda

    European radiology   27 ( 2 )   498 - 506   2017.2

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    DOI: 10.1007/s00330-016-4386-3

  • Extrahepatic cholangiocarcinoma and pancreatic duct adenocarcinoma

    Shinichi Aishima

    Biliary Diseases with Pancreatic Counterparts: A New Disease Concept   85 - 109   2017.1

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  • Inverse correlation between CD8+ inflammatory cells and E-cadherin expression in gallbladder cancer: Tissue microarray and imaging analysis. International journal

    Keita Kai, Masanori Masuda, Shinichi Aishima

    World journal of clinical cases   5 ( 1 )   1 - 8   2017.1

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    DOI: 10.12998/wjcc.v5.i1.1

  • Clinical Significances of Preoperative Classification of Intrahepatic Cholangiocarcinoma: Different Characteristics of Perihilar vs. Peripheral ICC. International journal

    Yo-Ichi Yamashita, Huanlin Wang, Takeshi Kurihara, Eiji Tsujita, Akihiro Nishie, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Shinichi Aishima, Hideo Baba

    Anticancer research   36 ( 12 )   6563 - 6569   2016.12

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    DOI: 10.21873/anticanres.11260

  • Fatty change in moderately and poorly differentiated hepatocellular carcinoma on MRI: a possible mechanism related to decreased arterial flow

    Y. Asayama, A. Nishie, K. Ishigami, Y. Ushijima, Y. Takayama, D. Okamoto, N. Fujita, Y. Kubo, S. Aishima, T. Yoshizumi, H. Honda

    Clinical Radiology   71 ( 12 )   1277 - 1283   2016.12

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    DOI: 10.1016/j.crad.2016.04.020

  • Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1α and malignant potential in pancreatic neuroendocrine tumors. International journal

    12 ( 5 )   3337 - 3343   2016.11

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    The present study aimed to investigate the prognostic usefulness of the expression of glucose transporter type 1 (GLUT-1) and GLUT-2, hypoxia-inducible factor 1α (HIF-1α) and insulin-like growth factor II messenger RNA-binding protein 3 (IMP3) in pancreatic neuroendocrine tumors (pNETs). Immunohistochemical staining for GLUT-1, GLUT-2, HIF-1α and IMP3 was performed in 70 pNET specimens. The expression of GLUT-1 and HIF-1α was significantly higher in the World Health Organization grade 2 (G2), neuroendocrine carcinoma cases and mixed-type pNETs compared with the G1 cases. Vessel invasion, a high Ki-67 labeling index and a high mitotic count were significantly more frequent in the GLUT-1- and HIF-1α-positive cases compared with the negative cases. Lymph node metastasis was significantly higher in the GLUT-1-positive cases than in the negative cases. Insulin expression was significantly higher in the IMP3-positive cases than the negative cases. The GLUT-1 expression group experienced a significantly poor disease-free survival rate compared with the negative GLUT-1 expression group. HIF-1α expression was significantly correlated with poor disease-free survival and overall survival rates. A multivariate analysis revealed that lymph node metastasis was an independent risk factor for disease-free survival in all cases. In the G1/G2 group, tumor size and lymph node metastasis were independent risk factors for disease-free survival. Overall, the results suggested that GLUT-1 is a useful prognostic biomarker for pNETs.

    DOI: 10.3892/ol.2016.5092

  • Malignant transformation of hepatocellular adenoma with bone marrow metaplasia arising in glycogen storage disease type I: A case report. International journal

    Tomohiro Iguchi, Motoyuki Yamagata, Takashi Sonoda, Kimihiko Yanagita, Tetsuhiro Fukahori, Eiji Tsujita, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara

    Molecular and clinical oncology   5 ( 5 )   599 - 603   2016.11

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  • Effect of EGFR and p-AKT Overexpression on Chromosomal Instability in Gastric Cancer. International journal

    Yuichi Hisamatsu, Eiji Oki, Hajime Otsu, Koji Ando, Hiroshi Saeki, Eriko Tokunaga, Shinichi Aishima, Masaru Morita, Yoshinao Oda, Yoshihiko Maehara

    Annals of surgical oncology   23 ( 6 )   1986 - 92   2016.6

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    DOI: 10.1245/s10434-016-5097-3

  • Spalt-like transcription factor 4 immunopositivity is associated with epithelial cell adhesion molecule expression in combined hepatocellular carcinoma and cholangiocarcinoma. International journal

    Yuki Tanaka, Shinichi Aishima, Kenichi Kohashi, Yukihiko Okumura, Huanlin Wang, Tomoyuki Hida, Kazuhiro Kotoh, Ken Shirabe, Yoshihiko Maehara, Ryoichi Takayanagi, Yoshinao Oda

    Histopathology   68 ( 5 )   693 - 701   2016.4

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    DOI: 10.1111/his.12806

  • Cytokeratin immunohistochemistry improves interobserver variability between unskilled pathologists in the evaluation of tumor budding in T1 colorectal cancer. International journal

    Keita Kai, Shinichi Aishima, Shigehisa Aoki, Yukari Takase, Kazuyoshi Uchihashi, Masanori Masuda, Aki Nishijima-Matsunobu, Mihoko Yamamoto, Kousuke Ide, Atsushi Nakayama, Makiko Yamasaki, Shuji Toda

    Pathology international   66 ( 2 )   75 - 82   2016.2

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    DOI: 10.1111/pin.12374

  • Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. International journal

    113 ( 1 )   E71-80 - E80   2016.1

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    Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double deficiency in mouse liver (LMob1DKO) results in hyperplasia of oval cells and immature cholangiocytes accompanied by inflammatory cell infiltration and fibrosis. More than half of mutant mice die within 3 wk of birth. All survivors eventually develop liver cancers, particularly combined hepatocellular and cholangiocarcinomas (cHC-CCs) and intrahepatic cholangiocellular carcinomas (ICCs), and die by age 60 wk. Because this phenotype is the most severe among mutant mice lacking a Hippo signaling component, MOB1A/1B constitute the critical hub of Hippo signaling in mammalian liver. LMob1DKO liver cells show hyperproliferation, increased cell saturation density, hepatocyte dedifferentiation, enhanced epithelial-mesenchymal transition and cell migration, and elevated transforming growth factor beta(TGF-β)2/3 production. These changes are strongly dependent on Yes-Associated Protein-1 (Yap1) and partially dependent on PDZ-binding motif (Taz) and Tgfbr2, but independent of connective tissue growth factor (Ctgf). In human liver cancers, YAP1 activation is frequent in cHC-CCs and ICCs and correlates with SMAD family member 2 activation. Drug screening revealed that antiparasitic macrocyclic lactones inhibit YAP1 activation in vitro and in vivo. Targeting YAP1/TAZ with these drugs in combination with inhibition of the TGF-β pathway may be effective treatment for cHC-CCs and ICCs.

    DOI: 10.1073/pnas.1517188113

  • Predictors and Diagnostic Strategies for Early-Stage Pancreatic Ductal Adenocarcinoma: A Retrospective Study. International journal

    Hideyo Kimura, Takao Ohtsuka, Taketo Matsunaga, Yusuke Watanabe, Koji Tamura, Noboru Ideno, Teppei Aso, Tetsuyuki Miyazaki, Takashi Osoegawa, Shinichi Aishima, Yoshihiro Miyasaka, Junji Ueda, Yasuhiro Ushijima, Hisato Igarashi, Tetsuhide Ito, Shunichi Takahata, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

    Pancreas   44 ( 7 )   1148 - 54   2015.10

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    DOI: 10.1097/MPA.0000000000000393

  • Impact of GATA-3 and FOXA1 expression in patients with hormone receptor-positive/HER2-negative breast cancer.

    Yuichi Hisamatsu, Eriko Tokunaga, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Yuichiro Nakashima, Kenji Taketani, Shinichi Aishima, Yoshinao Oda, Masaru Morita, Yoshihiko Maehara

    Breast cancer (Tokyo, Japan)   22 ( 5 )   520 - 8   2015.9

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    DOI: 10.1007/s12282-013-0515-x

  • Predictors of Microvascular Invasion in Hepatocellular Carcinoma. International journal

    Yo-Ichi Yamashita, Ken Shirabe, Shinichi Aishima, Yoshihiko Maehara

    Digestive diseases (Basel, Switzerland)   33 ( 5 )   655 - 60   2015.9

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    DOI: 10.1159/000438475

  • Granulomatous reaction in hepatic inflammatory angiomyolipoma after chemoembolization and spontaneous rupture. International journal

    Keita Kai, Atsushi Miyosh, Shinichi Aishima, Kota Wakiyama, Shunya Nakashita, Shinji Iwane, Shinya Azama, Hiroyuki Irie, Hirokazu Noshiro

    World journal of gastroenterology   21 ( 32 )   9675 - 82   2015.8

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    DOI: 10.3748/wjg.v21.i32.9675

  • Surgical Outcomes of Hepatic Resection for Hepatitis B Virus Surface Antigen-Negative and Hepatitis C Virus Antibody-Negative Hepatocellular Carcinoma. International journal

    Yo-Ichi Yamashita, Daisuke Imai, Yuki Bekki, Koichi Kimura, Yoshiriro Matsumoto, Hidekazu Nakagawara, Toru Ikegami, Tomoharu Yoshizumi, Ken Shirabe, Shinichi Aishima, Yoshihiko Maehara

    Annals of surgical oncology   22 ( 7 )   2279 - 85   2015.7

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    DOI: 10.1245/s10434-014-4261-x

  • New Pathologic Stratification of Microvascular Invasion in Hepatocellular Carcinoma: Predicting Prognosis After Living-donor Liver Transplantation. International journal

    Tomohiro Iguchi, Ken Shirabe, Shinichi Aishima, Huanlin Wang, Nobuhiro Fujita, Mizuki Ninomiya, Yo-ichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Tomoharu Yoshizumi, Yoshinao Oda, Yoshihiko Maehara

    Transplantation   99 ( 6 )   1236 - 42   2015.6

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    DOI: 10.1097/TP.0000000000000489

  • 桂枝加竜骨牡蛎湯,辛夷清肺湯による薬物性肝障害の1例

    道免 和文, 田中 博文, 春野 政虎, 下田 慎治, 相島 慎一

    日本消化器病学会雑誌   112 ( 6 )   1054 - 9   2015.6

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    症例は35歳時に桂枝加竜骨牡蛎湯による肝障害歴のある43歳の女性.副鼻腔炎に対し処方された辛夷清肺湯の内服後に総ビリルビン,AST,ALTの上昇がみられ,当科に紹介入院となった.辛夷清肺湯の薬物性肝障害と診断し,薬剤の中止で肝機能は正常化した.肝組織像もリンパ球・好酸球浸潤,巣状壊死の所見を認め,薬物性肝障害に合致した.桂枝加竜骨牡蛎湯,辛夷清肺湯による薬物性肝障害の報告はなく,貴重な症例と考えられた.

    DOI: 10.11405/nisshoshi.112.1054

  • Reply to Letter to the Editor by Pujals et al. International journal

    65 ( 6 )   339 - 339   2015.6

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    DOI: 10.1111/pin.12307

  • Recurrence 11 years after complete response to gemcitabine, 5-Fluorouracil, and Cisplatin chemotherapy followed by radiotherapy in a patient with advanced pancreatic cancer: a case report. International journal

    Tomoyuki Uchihara, Yo-Ichi Yamashita, Wang Hualin, Kazuki Takeishi, Shinji Itoh, Norihumi Harimoto, Tomoharu Yoshizumi, Shinichi Aishima, Ken Shirabe, Hideo Baba, Yoshihiko Maehara

    Anticancer research   35 ( 5 )   2867 - 71   2015.5

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  • Correlation of HER2 expression with clinicopathological characteristics and prognosis in resectable gastric cancer. International journal

    Hajime Otsu, Eiji Oki, Ayae Ikawa-Yoshida, Hiroyuki Kawano, Koji Ando, Satoshi Ida, Yasue Kimura, Shinichi Aishima, Hiroshi Saeki, Masaru Morita, Shunji Kohnoe, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   35 ( 4 )   2441 - 6   2015.4

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  • Long-term outcome of living-donor liver transplantation for combined hepatocellular-cholangiocarcinoma. International journal

    Shinji Itoh, Toru Ikegami, Tomoharu Yoshizumi, Huanlin Wang, Kazuki Takeishi, Norifumi Harimoto, Yo-Ichi Yamashita, Hirofumi Kawanaka, Shinichi Aishima, Ken Shirabe, Yoshihiko Maehara

    Anticancer research   35 ( 4 )   2475 - 6   2015.4

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  • Hepatology: Rare Stevens-Johnson syndrome and vanishing bile duct syndrome induced by acetaminophen, requiring liver transplantation

    N. Harimoto, H. Wang, T. Ikegami, K. Takeishi, S. Itoh, Y. I. Yamashita, T. Yoshizumi, S. Aishima, K. Shirabe, Y. Oda, Y. Maehara

    Journal of Gastroenterology and Hepatology (Australia)   30 ( 4 )   656 - 656   2015.4

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    DOI: 10.1111/jgh.12849

  • Granulomatous interstitial pneumonia induced by the intake of rice bran pickles: a rare subtype of pulmonary manifestation associated with food allergy. International journal

    Yoshiaki Kinoshita, Atsuhiko Sakamoto, Shinichi Aishima, Kouko Hidaka

    BMJ case reports   2015   2015.4

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    DOI: 10.1136/bcr-2014-208261

  • Evaluation of techniques to prevent colorectal anastomotic leakage. International journal

    Tetsuo Ikeda, Ryuichi Kumashiro, Eiji Oki, Kenji Taketani, Koji Ando, Shinichi Aishima, Tomohiko Akahoshi, Masaru Morita, Yoshihiko Maehara

    The Journal of surgical research   194 ( 2 )   450 - 457   2015.4

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    DOI: 10.1016/j.jss.2014.11.045

  • Clinical significance of GNAS mutation in intraductal papillary mucinous neoplasm of the pancreas with concomitant pancreatic ductal adenocarcinoma. International journal

    Noboru Ideno, Takao Ohtsuka, Taketo Matsunaga, Hideyo Kimura, Yusuke Watanabe, Koji Tamura, Teppei Aso, Shinichi Aishima, Yoshihiro Miyasaka, Kenoki Ohuchida, Junji Ueda, Shunichi Takahata, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

    Pancreas   44 ( 2 )   311 - 20   2015.3

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    DOI: 10.1097/MPA.0000000000000258

  • [α-Fetoprotein-producing tumor].

    73 Suppl 3   784 - 7   2015.3

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  • Primary hepatic tumors with myxoid change: morphologically unique hepatic adenomas and hepatocellular carcinomas. International journal

    Safia N Salaria, Rondell P Graham, Shinichi Aishima, Taofic Mounajjed, Matthew M Yeh, Michael S Torbenson

    The American journal of surgical pathology   39 ( 3 )   318 - 24   2015.3

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    DOI: 10.1097/PAS.0000000000000382

  • Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. International journal

    Yusuke Mizuuchi, Shinichi Aishima, Kenoki Ohuchida, Koji Shindo, Minoru Fujino, Masami Hattori, Tetsuyuki Miyazaki, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

    Laboratory investigation; a journal of technical methods and pathology   95 ( 2 )   193 - 206   2015.2

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    DOI: 10.1038/labinvest.2014.138

  • Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type.

    Shinichi Aishima, Yoshinao Oda

    Journal of hepato-biliary-pancreatic sciences   22 ( 2 )   94 - 100   2015.2

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    DOI: 10.1002/jhbp.154

  • A novel serum marker, glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA(+)-M2BP), for assessing liver fibrosis.

    Takeo Toshima, Ken Shirabe, Toru Ikegami, Tomoharu Yoshizumi, Atsushi Kuno, Akira Togayachi, Masanori Gotoh, Hisashi Narimatsu, Masaaki Korenaga, Masashi Mizokami, Akihito Nishie, Shinichi Aishima, Yoshihiko Maehara

    Journal of gastroenterology   50 ( 1 )   76 - 84   2015.1

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    DOI: 10.1007/s00535-014-0946-y

  • Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy.

    Yuichiroh Umemoto, Shinji Okano, Yoshihiro Matsumoto, Hidekazu Nakagawara, Rumi Matono, Shohei Yoshiya, Yo-Ichi Yamashita, Tomoharu Yoshizumi, Toru Ikegami, Yuji Soejima, Mamoru Harada, Shinichi Aishima, Yoshinao Oda, Ken Shirabe, Yoshihiko Maehara

    Journal of gastroenterology   50 ( 1 )   65 - 75   2015.1

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    DOI: 10.1007/s00535-014-0933-3

  • Hepatocellular carcinoma: clinical significance of signal heterogeneity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging. International journal

    Nobuhiro Fujita, Akihiro Nishie, Yuichiro Kubo, Yoshiki Asayama, Yasuhiro Ushijima, Yukihisa Takayama, Koichiro Moirta, Ken Shirabe, Shinichi Aishima, Hiroshi Honda

    European radiology   25 ( 1 )   211 - 20   2015.1

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    DOI: 10.1007/s00330-014-3349-9

  • Different histological sequelae of immune-mediated graft dysfunction after interferon treatment in transplanted dual grafts from living donors. International journal

    Mizuki Ninomiya, Shinichi Aishima, Tomoharu Yoshizumi, Toru Ikegami, Huanlin Wang, Norifumi Harimoto, Shinji Ito, Hideaki Uchiyama, Yuji Soejima, Hirofumi Kawanaka, Ken Shirabe, Yoshihiko Maehara

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society   20 ( 12 )   1520 - 2   2014.12

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    DOI: 10.1002/lt.23996

  • Micro RNA-373 is down-regulated in pancreatic cancer and inhibits cancer cell invasion. International journal

    Kohei Nakata, Kenoki Ohuchida, Kazuhiro Mizumoto, Shinichi Aishima, Yoshinao Oda, Eishi Nagai, Masao Tanaka

    Annals of surgical oncology   21 Suppl 4 ( 4 )   S564-74 - 574   2014.12

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    DOI: 10.1245/s10434-014-3676-8

  • "High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas. International journal

    Teppei Aso, Takao Ohtsuka, Taketo Matsunaga, Hideyo Kimura, Yusuke Watanabe, Koji Tamura, Noboru Ideno, Takashi Osoegawa, Shunnichi Takahata, Koji Shindo, Yasuhiro Ushijima, Shinichi Aishima, Yoshinao Oda, Tetsuhide Ito, Kazuhiro Mizumoto, Masao Tanaka

    Pancreas   43 ( 8 )   1239 - 43   2014.11

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    DOI: 10.1097/MPA.0000000000000199

  • Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: pathogenesis and histological characteristics. International journal

    Shinichi Aishima, Yuki Tanaka, Yuichiro Kubo, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

    Pathology international   64 ( 11 )   551 - 9   2014.11

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    DOI: 10.1111/pin.12209

  • Gallbladder cancer: Clinical and pathological approach. International journal

    Keita Kai, Shinichi Aishima, Kohji Miyazaki

    World journal of clinical cases   2 ( 10 )   515 - 21   2014.10

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    DOI: 10.12998/wjcc.v2.i10.515

  • The apelin-APJ system induces tumor arteriogenesis in hepatocellular carcinoma. International journal

    Jun Muto, Ken Shirabe, Tomoharu Yoshizumi, Toru Ikegami, Shinichi Aishima, Kousei Ishigami, Yoshikazu Yonemitsu, Tetsuo Ikeda, Yuji Soejima, Yoshihiko Maehara

    Anticancer research   34 ( 10 )   5313 - 20   2014.10

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  • Pathological manifestation of difference in washout pattern of adrenal hyperplasia on dynamic CT. International journal

    Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, Yasuhiro Ushijima, Yukihisa Takayama, Akira Yokomizo, Katsunori Tatsugami, Junichi Inokuchi, Nobuhiro Fujita, Yuichiro Kubo, Shinichi Aishima, Masakazu Hirakawa, Hiroshi Honda

    Journal of medical imaging and radiation oncology   58 ( 5 )   559 - 64   2014.10

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    DOI: 10.1111/1754-9485.12211

  • Correlation between biological marker expression and fluorine-18 fluorodeoxyglucose uptake in hepatocellular carcinoma. International journal

    Yohei Mano, Shinichi Aishima, Yuichiro Kubo, Yuki Tanaka, Takashi Motomura, Takeo Toshima, Ken Shirabe, Shingo Baba, Yoshihiko Maehara, Yoshinao Oda

    American journal of clinical pathology   142 ( 3 )   391 - 7   2014.9

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    DOI: 10.1309/AJCPG8AFJ5NRKLLM

  • Podoplanin expression in the cyst wall correlates with the progression of intraductal papillary mucinous neoplasm. International journal

    Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Takao Ohtsuka, Shoji Tokunaga, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

    Virchows Archiv : an international journal of pathology   465 ( 3 )   265 - 73   2014.9

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    DOI: 10.1007/s00428-014-1610-x

  • Pancreatic intraepithelial neoplasia in the background of invasive ductal carcinoma of the pancreas as a prognostic factor. International journal

    Yasunori Oda, Shinichi Aishima, Katsuya Morimatsu, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Tetsuyuki Miyazaki, Masao Tanaka, Yoshinao Oda

    Histopathology   65 ( 3 )   389 - 97   2014.9

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    DOI: 10.1111/his.12397

  • Different expression of glucose transporters in the progression of intrahepatic cholangiocarcinoma. International journal

    Yuichiro Kubo, Shinichi Aishima, Yuki Tanaka, Koji Shindo, Yusuke Mizuuchi, Koichiro Abe, Ken Shirabe, Yoshihiko Maehara, Hiroshi Honda, Yoshinao Oda

    Human pathology   45 ( 8 )   1610 - 7   2014.8

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    DOI: 10.1016/j.humpath.2014.03.008

  • Significance of accurate human epidermal growth factor receptor-2 (HER2) evaluation as a new biomarker in gastric cancer. International journal

    Yasue Kimura, Eiji Oki, Ayae Yoshida, Shinichi Aishima, Yoko Zaitsu, Hajime Ohtsu, Koji Ando, Satoshi Ida, Hiroshi Saeki, Masaru Morita, Tetsuya Kusumoto, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   34 ( 8 )   4207 - 12   2014.8

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  • Histological features of precancerous and early cancerous lesions of biliary tract carcinoma.

    Shinichi Aishima, Yuichiro Kubo, Yuki Tanaka, Yoshinao Oda

    Journal of hepato-biliary-pancreatic sciences   21 ( 7 )   448 - 52   2014.7

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    DOI: 10.1002/jhbp.71

  • Phase II study of docetaxel and S-1 (DS) as neoadjuvant chemotherapy for clinical stage III resectable gastric cancer. International journal

    Eiji Oki, Yasunori Emi, Tetsuya Kusumoto, Yoshihisa Sakaguchi, Manabu Yamamoto, Noriaki Sadanaga, Mototsugu Shimokawa, Takeharu Yamanaka, Hiroshi Saeki, Masaru Morita, Ikuo Takahashi, Naoki Hirabayashi, Kenji Sakai, Hiroyuki Orita, Shinichi Aishima, Yoshihiro Kakeji, Kazuya Yamaguchi, Kazuhiro Yoshida, Hideo Baba, Yoshihiko Maehara

    Annals of surgical oncology   21 ( 7 )   2340 - 6   2014.7

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    DOI: 10.1245/s10434-014-3594-9

  • Peritoneal myofibroblasts at metastatic foci promote dissemination of pancreatic cancer. International journal

    Shin Akagawa, Kenoki Ohuchida, Nobuhiro Torata, Masami Hattori, Daiki Eguchi, Kenji Fujiwara, Shingo Kozono, Lin Cui, Naoki Ikenaga, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto, Yoshinao Oda, Masao Tanaka

    International journal of oncology   45 ( 1 )   113 - 20   2014.7

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    DOI: 10.3892/ijo.2014.2391

  • New scoring system for prediction of microvascular invasion in patients with hepatocellular carcinoma. International journal

    Ken Shirabe, Takeo Toshima, Koichi Kimura, Yoichi Yamashita, Tetsuo Ikeda, Toru Ikegami, Tomoharu Yoshizumi, Koichiro Abe, Shinichi Aishima, Yoshihiko Maehara

    Liver international : official journal of the International Association for the Study of the Liver   34 ( 6 )   937 - 41   2014.7

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    DOI: 10.1111/liv.12459

  • Analysis of risk factors for recurrence after curative resection of well-differentiated pancreatic neuroendocrine tumors based on the new grading classification.

    Kosuke Tsutsumi, Takao Ohtsuka, Minoru Fujino, Hiroshi Nakashima, Shinichi Aishima, Junji Ueda, Shunichi Takahata, Masafumi Nakamura, Yoshinao Oda, Masao Tanaka

    Journal of hepato-biliary-pancreatic sciences   21 ( 6 )   418 - 25   2014.6

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    DOI: 10.1002/jhbp.47

  • Role of tumor-associated macrophages in the angiogenesis of well-differentiated hepatocellular carcinoma: pathological-radiological correlation. International journal

    Nobuhiro Fujita, Akihiro Nishie, Shinichi Aishima, Yuichiro Kubo, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Yasuhiro Ushijima, Yukihisa Takayama, Ken Shirabe, Yoshinao Oda, Hiroshi Honda

    Oncology reports   31 ( 6 )   2499 - 505   2014.6

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    DOI: 10.3892/or.2014.3138

  • Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma. International journal

    Mikako Osada, Shinichi Aishima, Minako Hirahashi, Nobuyoshi Takizawa, Shunsuke Takahashi, Kazuhiko Nakamura, Masao Tanaka, Yoshihiko Maehara, Ryoichi Takayanagi, Yoshinao Oda

    Human pathology   45 ( 6 )   1243 - 50   2014.6

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    DOI: 10.1016/j.humpath.2014.02.003

  • Chronic immune-mediated reaction syndrome as the cause of late graft mortality in living-donor liver transplantation for primary biliary cirrhosis

    N. Harimoto, T. Ikegami, H. Nakagawara, Y. I. Yamashita, T. Yoshizumi, H. Uchiyama, Y. Soejima, T. Ikeda, K. Shirabe, S. Aishima, Y. Oda, Y. Maehara

    Transplantation Proceedings   46 ( 5 )   1438 - 1443   2014.6

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    DOI: 10.1016/j.transproceed.2014.02.021

  • Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer.

    Eriko Tokunaga, Yuichiro Nakashima, Nami Yamashita, Yuichi Hisamatsu, Satoko Okada, Sayuri Akiyoshi, Shinichi Aishima, Hiroyuki Kitao, Masaru Morita, Yoshihiko Maehara

    Breast cancer (Tokyo, Japan)   21 ( 3 )   341 - 9   2014.5

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    DOI: 10.1007/s12282-012-0398-2

  • A case of invasive micropapillary carcinoma of the breast involving extensive lymph node metastasis. International journal

    Kenji Taketani, Eriko Tokunaga, Nami Yamashita, Kimihiro Tanaka, Yoko Zaitsu, Sayuri Akiyoshi, Satoko Okada, Shinichi Aishima, Masaru Morita, Yoshihiko Maehara

    World journal of surgical oncology   12 ( 1 )   84 - 84   2014.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1477-7819-12-84

  • Strategies to treat interferon-induced graft dysfunction after living donor liver transplantation for hepatitis C. International journal

    Toru Ikegami, Huanlin Wang, Tomoharu Yoshizumi, Takeo Toshima, Shinichi Aishima, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Shinji Shimoda, Ken Shirabe, Yoshihiko Maehara

    Hepatology international   8 ( 2 )   285 - 92   2014.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12072-013-9496-2

  • Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients. International journal

    Minako Hirahashi, Yutaka Koga, Reiko Kumagai, Shinichi Aishima, Kenichi Taguchi, Yoshinao Oda

    Pathology international   64 ( 4 )   155 - 63   2014.4

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    DOI: 10.1111/pin.12152

  • Elevated expression level of microRNA-196a is predictive of intestinal-type intraductal papillary mucinous neoplasm of the pancreas. International journal

    Teppei Aso, Takao Ohtsuka, Koji Tamura, Noboru Ideno, Hiroshi Kono, Yosuke Nagayoshi, Kennoki Ohuchida, Junji Ueda, Shunnichi Takahata, Koji Shindo, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

    Pancreas   43 ( 3 )   361 - 6   2014.4

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    DOI: 10.1097/MPA.0000000000000042

  • Key endoscopic ultrasound features of pancreatic ductal adenocarcinoma smaller than 20 mm. International journal

    Akira Aso, Eikichi Ihara, Takashi Osoegawa, Kazuhiko Nakamura, Soichi Itaba, Hisato Igarashi, Tetsuhide Ito, Shinichi Aishima, Yoshinao Oda, Masao Tanaka, Ryoichi Takayanagi

    Scandinavian journal of gastroenterology   49 ( 3 )   332 - 8   2014.3

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    DOI: 10.3109/00365521.2013.878745

  • Follicular pancreatitis, report of a case clinically mimicking pancreatic cancer and literature review. International journal

    Yusuke Mizuuchi, Shinichi Aishima, Masami Hattori, Yasuhiro Ushijima, Akira Aso, Shunichi Takahata, Takao Ohtsuka, Junji Ueda, Masao Tanaka, Yoshinao Oda

    Pathology, research and practice   210 ( 2 )   118 - 22   2014.2

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    DOI: 10.1016/j.prp.2013.09.005

  • Treatment strategy for main duct intraductal papillary mucinous neoplasms of the pancreas based on the assessment of recurrence in the remnant pancreas after resection: a retrospective review. International journal

    Koji Tamura, Takao Ohtsuka, Noboru Ideno, Teppei Aso, Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Shunichi Takahata, Yasuhiro Ushijima, Tetsuhide Ito, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

    Annals of surgery   259 ( 2 )   360 - 8   2014.2

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    DOI: 10.1097/SLA.0b013e3182a690ff

  • Expression of glucagon-like Peptide 1 receptor and its effects on biologic behavior in pancreatic neuroendocrine tumors. International journal

    Ana Ines Cases, Takao Ohtsuka, Minoru Fujino, Noboru Ideno, Shingo Kozono, Ming Zhao, Kenoki Ohuchida, Shinichi Aishima, Masatoshi Nomura, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

    Pancreas   43 ( 1 )   1 - 6   2014.1

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    DOI: 10.1097/MPA.0b013e3182a71537

  • Tissue tablet method: an efficient tissue banking procedure applicable to both molecular analysis and frozen tissue microarray. International journal

    Nobuhiro Torata, Kenoki Ohuchida, Shin Akagawa, Lin Cui, Shingo Kozono, Kazuhiro Mizumoto, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

    Human pathology   45 ( 1 )   143 - 52   2014.1

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    DOI: 10.1016/j.humpath.2013.08.013

  • Spontaneous massive necrosis of hepatocellular carcinoma with narrowing and occlusion of the arteries and portal veins. International journal

    Takahiro Tomino, Yo-Ichi Yamashita, Tomohiro Iguchi, Shinji Itoh, Mizuki Ninomiya, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Hirofumi Kawanaka, Tetsuo Ikeda, Shinichi Aishima, Ken Shirabe, Yoshihiko Maehara

    Case reports in gastroenterology   8 ( 1 )   148 - 55   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000362440

  • Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia.

    Yasunori Sato, Motoko Sasaki, Kenichi Harada, Shinichi Aishima, Toshio Fukusato, Hidenori Ojima, Yae Kanai, Masayoshi Kage, Yasuni Nakanuma, Hirohito Tsubouchi

    Journal of gastroenterology   49 ( 1 )   64 - 72   2014.1

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    DOI: 10.1007/s00535-013-0810-5

  • Intraoperative irrigation cytology of the remnant pancreas to detect remnant distinct pancreatic ductal adenocarcinoma in patients with intraductal papillary mucinous neoplasm undergoing partial pancreatectomy. International journal

    Yasuhisa Mori, Takao Ohtsuka, Koji Tamura, Noboru Ideno, Teppei Aso, Hiroshi Kono, Yosuke Nagayoshi, Junji Ueda, Shunichi Takahata, Shinichi Aishima, Fumihiko Ookubo, Yoshinao Oda, Masao Tanaka

    Surgery   155 ( 1 )   67 - 73   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.surg.2013.06.059

  • Differential impact of the expression of the androgen receptor by age in estrogen receptor-positive breast cancer. International journal

    Eriko Tokunaga, Yuichi Hisamatsu, Kenji Taketani, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Kimihiro Tanaka, Hiroshi Saeki, Eiji Oki, Shinichi Aishima, Yoshinao Oda, Masaru Morita, Yoshihiko Maehara

    Cancer medicine   2 ( 6 )   763 - 73   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cam4.138

  • mFOLFOX6療法後に発症した門脈圧亢進症の1例

    緒方 大聡, 具嶋 敏文, 丸岡 新子, 高崎 智子, 田中 吏佐, 松浦 隆志, 相島 慎一, 高橋 和弘

    日本消化器病学会雑誌   110 ( 12 )   2119 - 26   2013.12

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    症例は46歳男性.S状結腸癌肝転移の診断でS状結腸切除術,肝部分切除術,胆嚢切除術を施行された.術後化学療法としてmFOLFOX6療法を施行された頃から血小板減少と脾腫が出現し,3年後にF3の食道胃静脈瘤を認めた.肝生検組織では,大腸癌手術時の摘出肝と比して類洞の拡張に加え門脈が狭小化して不明瞭となっていた.Oxaliplatinは非肝硬変性の門脈圧亢進症をきたすことがあり,留意すべきである.

    DOI: 10.11405/nisshoshi.110.2119, 10.2957/kanzo.61.358_references_DOI_UKRW5UlBD1NDFXslFg78J5YToE0, 10.5833/jjgs.2017.0194_references_DOI_UKRW5UlBD1NDFXslFg78J5YToE0

  • Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas. International journal

    Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Kenji Fujiwara, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

    Molecular cancer   12 ( 1 )   168 - 168   2013.12

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    DOI: 10.1186/1476-4598-12-168

  • Decreased roundabout 1 expression promotes development of intrahepatic cholangiocarcinoma. International journal

    Yohei Mano, Shinichi Aishima, Takasuke Fukuhara, Yuki Tanaka, Yuichiro Kubo, Takashi Motomura, Takeo Toshima, Tomohiro Iguchi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

    Human pathology   44 ( 11 )   2419 - 26   2013.11

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    DOI: 10.1016/j.humpath.2013.03.022

  • Migratory activity of CD105+ pancreatic cancer cells is strongly enhanced by pancreatic stellate cells. International journal

    Kenji Fujiwara, Kenoki Ohuchida, Takao Ohtsuka, Kazuhiro Mizumoto, Koji Shindo, Naoki Ikenaga, Lin Cui, Shunichi Takahata, Shinichi Aishima, Masao Tanaka

    Pancreas   42 ( 8 )   1283 - 90   2013.11

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    DOI: 10.1097/MPA.0b013e318293e7bd

  • A case of fatal intrahepatic cholestasis with primary AL amyloidosis: is early diagnosis possible?

    Shinichiro Takao, Kosuke Tanaka, Masayuki Miyazaki, Masatake Tanaka, Tomoko Ohashi, Masaki Kato, Kazuhiro Kotoh, Shinichi Aishima, Ryoichi Takayanagi

    Clinical journal of gastroenterology   6 ( 5 )   386 - 9   2013.10

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    DOI: 10.1007/s12328-013-0406-x

  • Insulin-like growth factor II messenger RNA-binding protein-3 is a valuable diagnostic and prognostic marker of intraductal papillary mucinous neoplasm. International journal

    Katsuya Morimatsu, Shinichi Aishima, Hidetaka Yamamoto, Akifumi Hayashi, Kohei Nakata, Yasunori Oda, Koji Shindo, Minoru Fujino, Masao Tanaka, Yoshinao Oda

    Human pathology   44 ( 9 )   1714 - 21   2013.9

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    DOI: 10.1016/j.humpath.2012.12.020

  • Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas. International journal

    Yasunori Oda, Shinichi Aishima, Katsuya Morimatsu, Akifumi Hayashi, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Masao Tanaka, Yoshinao Oda

    Human pathology   44 ( 8 )   1487 - 98   2013.8

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    DOI: 10.1016/j.humpath.2012.12.001

  • S-1/Docetaxel併用療法にて同時性肝転移が病理学的完全奏効となった胃癌の1例

    北原大和, 沖英次, 佐伯浩司, 安藤幸滋, 調憲, 鴻江俊治, 相島慎一, 掛地吉弘, 前原喜彦

    癌と化学療法   40 ( 8 )   1093 - 7   2013.8

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  • Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis. International journal

    Yohei Mano, Ken Shirabe, Yo-Ichi Yamashita, Norifumi Harimoto, Eiji Tsujita, Kazuki Takeishi, Shinichi Aishima, Toru Ikegami, Tomoharu Yoshizumi, Takeharu Yamanaka, Yoshihiko Maehara

    Annals of surgery   258 ( 2 )   301 - 5   2013.8

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    DOI: 10.1097/SLA.0b013e318297ad6b

  • Distinctive histopathologic findings of pancreatic hamartomas suggesting their "hamartomatous" nature: a study of 9 cases. International journal

    Hiroshi Yamaguchi, Shinichi Aishima, Yoshinao Oda, Hiroki Mizukami, Takuma Tajiri, Sohsuke Yamada, Takashi Tasaki, Keisuke Yamakita, Koji Imai, Fumi Kawakami, Shigeo Hara, Keiji Hanada, Tomohiro Iiboshi, Toshikatsu Fukuda, Hiroshi Imai, Hiroyuki Inoue, Tatsuya Nagakawa, Shunji Muraoka, Toru Furukawa, Michio Shimizu

    The American journal of surgical pathology   37 ( 7 )   1006 - 13   2013.7

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    DOI: 10.1097/PAS.0b013e318283ce4c

  • Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype. International journal

    Noboru Ideno, Takao Ohtsuka, Hiroshi Kono, Kenji Fujiwara, Yasunori Oda, Shinichi Aishima, Tetsuhide Ito, Kousei Ishigami, Shoji Tokunaga, Kenoki Ohuchida, Shunichi Takahata, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

    Annals of surgery   258 ( 1 )   141 - 51   2013.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/SLA.0b013e31828cd008

  • High expression of microRNA-155 is associated with the aggressive malignant behavior of gallbladder carcinoma. International journal

    Hiroshi Kono, Masafumi Nakamura, Takao Ohtsuka, Yosuke Nagayoshi, Yasuhisa Mori, Shunichi Takahata, Shinichi Aishima, Masao Tanaka

    Oncology reports   30 ( 1 )   17 - 24   2013.7

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    DOI: 10.3892/or.2013.2443

  • Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma. International journal

    Shinichi Aishima, Yohei Mano, Yuki Tanaka, Yuichiro Kubo, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

    Human pathology   44 ( 6 )   1031 - 7   2013.6

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    DOI: 10.1016/j.humpath.2012.09.004

  • Early extensive viremia, but not rs8099917 genotype, is the only predictor for cholestatic hepatitis C after living-donor liver transplantation. International journal

    Toru Ikegami, Ken Shirabe, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Masaki Kato, Shinji Shimoda, Shinichi Aishima, Yuji Soejima, Tomoharu Yoshizumi, Yoshihiko Maehara

    Hepatology research : the official journal of the Japan Society of Hepatology   43 ( 6 )   621 - 9   2013.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.12003

  • Clinical usefulness of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography for patients with primary liver cancer with special reference to rare histological types, hepatocellular carcinoma with sarcomatous change and combined hepatocellular and cholangiocarcinoma. International journal

    Hideki Ijichi, Ken Shirabe, Akinobu Taketomi, Tomoharu Yoshizumi, Toru Ikegami, Youhei Mano, Shinichi Aishima, Koichiro Abe, Hiroshi Honda, Yoshihiko Maehara

    Hepatology research : the official journal of the Japan Society of Hepatology   43 ( 5 )   481 - 7   2013.5

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    DOI: 10.1111/j.1872-034X.2012.01107.x

  • Vimentin as a poor prognostic factor for triple-negative breast cancer. International journal

    Nami Yamashita, Eriko Tokunaga, Hiroyuki Kitao, Yuichi Hisamatsu, Kenji Taketani, Sayuri Akiyoshi, Satoko Okada, Shinichi Aishima, Masaru Morita, Yoshihiko Maehara

    Journal of cancer research and clinical oncology   139 ( 5 )   739 - 46   2013.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00432-013-1376-6

  • Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case.

    Mikihiro Kohno, Ken Shirabe, Yohei Mano, Jun Muto, Takashi Motomura, Kazuki Takeishi, Takeo Toshima, Masanori Yoshimatsu, Hideki Ijichi, Noboru Harada, Shinichi Aishima, Hideaki Uchiyama, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara

    Surgery today   43 ( 4 )   439 - 45   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-012-0202-0

  • Kindlin-1 expression is involved in migration and invasion of pancreatic cancer. International journal

    Prawej Mahawithitwong, Kenoki Ohuchida, Naoki Ikenaga, Hayato Fujita, Ming Zhao, Shingo Kozono, Koji Shindo, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto, Masao Tanaka

    International journal of oncology   42 ( 4 )   1360 - 6   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ijo.2013.1838

  • Ezrin expression and its phosphorylation in gastric carcinoma with lymphoid stroma and Epstein-Barr virus infection. International journal

    Taro Tobo, Minako Hirahashi, Takashi Yao, Shinichi Aishima, Yoshinao Oda

    Molecular and clinical oncology   1 ( 2 )   220 - 224   2013.3

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  • Role of endoscopic retrograde pancreatography for early detection of pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm of the pancreas.

    Takao Ohtsuka, Noboru Ideno, Teppei Aso, Yosuke Nagayoshi, Hiroshi Kono, Yasuhisa Mori, Shunichi Takahata, Yasunori Oda, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

    Journal of hepato-biliary-pancreatic sciences   20 ( 3 )   356 - 61   2013.3

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    DOI: 10.1007/s00534-012-0541-7

  • Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC. International journal

    Masatake Tanaka, Yuko Masaki, Kosuke Tanaka, Masayuki Miyazaki, Masaki Kato, Rie Sugimoto, Kazuhiko Nakamura, Shinichi Aishima, Ken Shirabe, Makoto Nakamuta, Munechika Enjoji, Kazuhiro Kotoh, Ryoichi Takayanagi

    Molecular medicine reports   7 ( 2 )   365 - 70   2013.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mmr.2012.1201

  • A morphological study of the removed livers from patients receiving living donor liver transplantation for adult biliary atresia. International journal

    Toshiharu Matsuura, Kenichi Kohashi, Yusuke Yanagi, Isamu Saeki, Makoto Hayashida, Shinichi Aishima, Yoshinao Oda, Tomoaki Taguchi

    Pediatric surgery international   28 ( 12 )   1171 - 5   2012.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00383-012-3183-6

  • Management strategy for multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas. International journal

    Yasuhisa Mori, Takao Ohtsuka, Hiroshi Kono, Noboru Ideno, Teppei Aso, Yosuke Nagayoshi, Shunichi Takahata, Masafumi Nakamura, Kousei Ishigami, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

    Pancreas   41 ( 7 )   1008 - 12   2012.10

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    DOI: 10.1097/MPA.0b013e31824b22c6

  • The risk of lymph node metastasis in mucosal gastric carcinoma: especially for a mixture of differentiated and undifferentiated adenocarcinoma. International journal

    Kohei Nakata, Eishi Nagai, Yoshihiro Miyasaka, Kenoki Ohuchida, Takao Ohtsuka, Hiroki Toma, Minako Hirahashi, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

    Hepato-gastroenterology   59 ( 118 )   1855 - 8   2012.9

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    DOI: 10.5754/hge10130

  • Diagnostic significance of a dilated orifice of the duodenal papilla in intraductal papillary mucinous neoplasm of the pancreas. International journal

    Teppei Aso, Takao Ohtsuka, Noboru Ideno, Hiroshi Kono, Yosuke Nagayoshi, Yasuhisa Mori, Kennoki Ohuchida, Junji Ueda, Shunnichi Takahata, Katsuya Morimatsu, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Kazuhiro Mizumoto, Masao Tanaka

    Gastrointestinal endoscopy   76 ( 2 )   313 - 20   2012.8

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    DOI: 10.1016/j.gie.2012.03.682

  • Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas. International journal

    Takao Ohtsuka, Hiroshi Kono, Reiko Tanabe, Yosuke Nagayoshi, Yasuhisa Mori, Yoshihiko Sadakari, Shunichi Takahata, Yasunori Oda, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

    American journal of surgery   204 ( 1 )   44 - 8   2012.7

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    DOI: 10.1016/j.amjsurg.2011.04.007

  • Primary graft dysfunction after living donor liver transplantation is characterized by delayed functional hyperbilirubinemia

    Toru Ikegami, K. Shirabe, T. Yoshizumi, S. Aishima, Y. A. Taketomi, Y. Soejima, H. Uchiyama, H. Kayashima, T. Toshima, Y. Maehara

    American Journal of Transplantation   12 ( 7 )   1886 - 1897   2012.7

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    DOI: 10.1111/j.1600-6143.2012.04052.x

  • Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production.

    Kosuke Tsutsumi, Takao Ohtsuka, Yasuhisa Mori, Minoru Fujino, Takaharu Yasui, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Tetsuhide Ito, Masao Tanaka

    Journal of gastroenterology   47 ( 6 )   678 - 85   2012.6

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    DOI: 10.1007/s00535-012-0540-0

  • Predictors for microinvasion of small hepatocellular carcinoma ≤ 2 cm. International journal

    19 ( 6 )   2027 - 34   2012.6

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    BACKGROUND: Hepatocellular carcinoma (HCC) ≤ 2 cm in diameter is considered to have a low potential for malignancy. METHODS: A retrospective review was undertaken of 149 patients with primary solitary HCC ≤ 2 cm who underwent initial hepatic resection between 1994 and 2010. The independent predictors of the microinvasion (MI) such as portal venous, hepatic vein, or bile duct infiltration and/or intrahepatic metastasis were identified by multivariate analysis. Prognosis of patients with HCC ≤ 2 cm accompanied by MI was compared to that of patients with HCC ≤ 2 cm without MI. RESULTS: Forty-three patients with HCC ≤ 2 cm had MI in patients (28.9%). Three independent predictors of the MI were revealed: invasive gross type (simple nodular type with extranodular growth or confluent multinodular type), des-γ-carboxy prothrombin (DCP) >100 mAU/ml, and poorly differentiated. Disease-free survival rates of patients with HCC ≤ 2 cm with MI (3 year 44%) were significantly worse than those for HCC ≤ 2 cm without MI (3 year 72%). This disadvantage of disease-free survival rate of patients with HCC ≤ 2 cm with MI could be dissolved by hepatic resection with a wide tumor margin of ≥ 5 mm (P = 0.04). CONCLUSIONS: Even in cases of HCC ≤ 2 cm, patients who are suspected of having invasive gross type tumors in preoperative imaging diagnosis or who have a high DCP level (>100 mAU/ml) are at risk for MI. Therefore, in such patients, hepatic resection with a wide tumor margin should be recommended.

    DOI: 10.1245/s10434-011-2195-0

  • Enhancement pattern analysis of hypervascular hepatocellular carcinoma on dynamic MR imaging with histopathological correlation: validity of portal phase imaging for predicting tumor grade. International journal

    Daisuke Okamoto, Kengo Yoshimitsu, Akihiro Nishie, Tsuyoshi Tajima, Yoshiki Asayama, Kousei Ishigami, Masakazu Hirakawa, Yasuhiro Ushijima, Daisuke Kakihara, Tomohiro Nakayama, Yunosuke Nishihara, Shinichi Aishima, Akinobu Taketomi, Junji Kishimoto, Hiroshi Honda

    European journal of radiology   81 ( 6 )   1116 - 21   2012.6

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    DOI: 10.1016/j.ejrad.2011.02.056

  • Impact of FOXA1 expression on the prognosis of patients with hormone receptor-positive breast cancer. International journal

    Yuichi Hisamatsu, Eriko Tokunaga, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Yuichiro Nakashima, Shinichi Aishima, Masaru Morita, Yoshihiro Kakeji, Yoshihiko Maehara

    Annals of surgical oncology   19 ( 4 )   1145 - 52   2012.4

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    DOI: 10.1245/s10434-011-2094-4

  • An increase in the number of predictive factors augments the likelihood of malignancy in branch duct intraductal papillary mucinous neoplasm of the pancreas. International journal

    Takao Ohtsuka, Hiroshi Kono, Yosuke Nagayoshi, Yasuhisa Mori, Kosuke Tsutsumi, Yoshihiko Sadakari, Shunichi Takahata, Katsuya Morimatsu, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

    Surgery   151 ( 1 )   76 - 83   2012.1

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    DOI: 10.1016/j.surg.2011.07.009

  • Total resection of the right hepatic vein drainage area with the aid of three-dimensional computed tomography.

    Akinobu Taketomi, Kazuki Takeishi, Yohei Mano, Takeo Toshima, Takashi Motomura, Shinichi Aishima, Hideaki Uchiyama, Tomoharu Yoshizumi, Ken Shirabe, Yoshihiko Maehara

    Surgery today   42 ( 1 )   46 - 51   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-011-0021-8

  • Uptake of Gd-EOB-DTPA by hepatocellular carcinoma: radiologic-pathologic correlation with special reference to bile production. International journal

    Yoshiki Asayama, Tsuyoshi Tajima, Akihiro Nishie, Kousei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, Daisuke Okamoto, Nobuhiro Fujita, Shinichi Aishima, Ken Shirabe, Hiroshi Honda

    European journal of radiology   80 ( 3 )   e243-8   2011.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejrad.2010.10.032

  • Nuclear atypia grading score is a useful prognostic factor in papillary gastric adenocarcinoma. International journal

    Yuichiro Nakashima, Takashi Yao, Minako Hirahashi, Shinichi Aishima, Yoshihiro Kakeji, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Histopathology   59 ( 5 )   841 - 9   2011.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2559.2011.04035.x

  • Histological and immunohistological findings in biliary intraepithelial neoplasia arising from a background of chronic biliary disease compared with liver cirrhosis of non-biliary aetiology. International journal

    Shinichi Aishima, Tomohiro Iguchi, Nobuhiro Fujita, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi, Yoshinao Oda

    Histopathology   59 ( 5 )   867 - 75   2011.11

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    DOI: 10.1111/j.1365-2559.2011.04011.x

  • MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis. International journal

    Kohei Nakata, Kenoki Ohuchida, Kazuhiro Mizumoto, Tadashi Kayashima, Naoki Ikenaga, Hiroshi Sakai, Cui Lin, Hayato Fujita, Takao Otsuka, Shinichi Aishima, Eishi Nagai, Yoshinao Oda, Masao Tanaka

    Surgery   150 ( 5 )   916 - 22   2011.11

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    DOI: 10.1016/j.surg.2011.06.017

  • 広範微小肺腫瘍塞栓によって呼吸不全を来たした肝細胞癌患者の一例

    田中 紘介, 中舎 晃男, 宮崎 将之, 高尾 信一郎, 樋口 野日斗, 田中 正剛, 田中 ゆき, 加藤 正樹, 古藤 和浩, 髙栁 涼一, 相島 慎一

    福岡醫學雜誌   102 ( 10 )   298 - 302   2011.10

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    肝細胞癌の肝外転移臓器として,肺は最も頻度の高い臓器である.CT やMR などの画像検査機器の発達により,肺転移巣の同定は容易となり,その診断に苦慮することは希である.また,肝細胞癌からの肺転移は高頻度であるにもかかわらず,呼吸不全に至る症例は少なく,多くの場合,肺転移巣が拡大して呼吸機能に影響を与えるようになる前に,原発の肝病変が進行して,肝不全に至る.今回我々は,肝細胞癌の経過観察中に,原因不明の呼吸不全が急速に進行した症例を経験した.入院時の画像検査で,肺の腫瘍性病変などの呼吸不全を来たす所見を認めず,酸素化が障害されている原因が不明であったが,死後の肺組織検査により,広範な微小腫瘍塞栓が認められた.肺の腫瘍塞栓によって,急速な呼吸不全を来たす病態として,Pulmonary tumor thrombotic microangiopathy(PTTM)があるが,本症例の病理所見では,PTTM は否定的であった.本症例の呼吸不全に関して若干の文献的考察を加えて報告する.

    DOI: 10.15017/20445

  • Cystic tumors of the liver: on the problems of diagnostic criteria. International journal

    Yohei Mano, Shinichi Aishima, Nobuhiro Fujita, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

    Pathology, research and practice   207 ( 10 )   659 - 63   2011.10

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    DOI: 10.1016/j.prp.2011.07.006

  • Histologic classification of microscopic portal venous invasion to predict prognosis in hepatocellular carcinoma. International journal

    Nobuhiro Fujita, Shinichi Aishima, Tomohiro Iguchi, Yohei Mano, Akinobu Taketomi, Ken Shirabe, Hiroshi Honda, Masazumi Tsuneyoshi, Yoshinao Oda

    Human pathology   42 ( 10 )   1531 - 8   2011.10

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    DOI: 10.1016/j.humpath.2010.12.016

  • Outcomes of hepatic resection for huge hepatocellular carcinoma (≥ 10 cm in diameter). International journal

    104 ( 3 )   292 - 8   2011.9

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    BACKGROUND: The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC) ≥ 10 cm. METHODS: Between 1995 and 2007, fifty-three patients with HCC ≥ 10 cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n = 12). Surgical results for HCC ≥ 10 cm were compared to those of patients with HCC < 10 cm (n = 412). The independent poor prognostic factors of the patients with HCC ≥ 10 cm were identified. RESULTS: Overall survival was significantly better in patients with hepatic resection for HCC ≥ 10 cm than in those with non-surgical treatment (P < 0.01). Survival rates of patients with hepatic resection for HCC ≥ 10 cm were 35&#37; at 5 years. Morbidity and mortality rate were statistically equal. The independent poor prognostic factors of patients with hepatic resection for HCC ≥ 10 cm were revealed: T4 status, macroscopic tumor thrombus in portal vein (VP+), and the use of intra-operative transfusion. CONCLUSION: Hepatic resections for HCC ≥ 10 cm are safe and efficacious. Minimizing intra-operative blood loss and the establishment of an effective systemic treatment for patients with HCC ≥ 10 cm in T4 appear to be critical.

    DOI: 10.1002/jso.21931

  • Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis. International journal

    Kohei Nakata, Kenoki Ohuchida, Shinichi Aishima, Yoshihiko Sadakari, Tadashi Kayashima, Yoshihiro Miyasaka, Eishi Nagai, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi, Yoshinao Oda

    Pancreas   40 ( 4 )   581 - 7   2011.5

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    DOI: 10.1097/MPA.0b013e318214fa86

  • Significance of dysadherin and E-cadherin expression in differentiated-type gastric carcinoma with submucosal invasion. International journal

    Yoshitomo Maehata, Minako Hirahashi, Shinichi Aishima, Junji Kishimoto, Setsuo Hirohashi, Takashi Yao, Hiroshi Takashima, Masazumi Tsuneyoshi, Yoshinao Oda

    Human pathology   42 ( 4 )   558 - 67   2011.4

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    DOI: 10.1016/j.humpath.2010.08.016

  • Different roles of S100P overexpression in intrahepatic cholangiocarcinoma: carcinogenesis of perihilar type and aggressive behavior of peripheral type. International journal

    Shinichi Aishima, Nobuhiro Fujita, Yohei Mano, Yuichiro Kubo, Yuki Tanaka, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

    The American journal of surgical pathology   35 ( 4 )   590 - 8   2011.4

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    DOI: 10.1097/PAS.0b013e31820ffdf1

  • Prognostic significance of preoperative imaging in recipients of living donor liver transplantation for hepatocellular carcinoma. International journal

    Keishi Sugimachi, Ken Shirabe, Akinobu Taketomi, Yuji Soejima, Tomohiro Iguchi, Kazuki Takeishi, Takeo Toshima, Shinichi Aishima, Tsuyoshi Tajima, Yoshihiko Maehara

    Transplantation   91 ( 5 )   570 - 4   2011.3

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    DOI: 10.1097/TP.0b013e318208134e

  • Prognostic importance of the gross classification of hepatocellular carcinoma in living donor-related liver transplantation

    K. Shirabe, S. Aishima, A. Taketomi, Y. Soejima, H. Uchiyama, H. Kayashima, M. Ninomiya, Y. Mano, Y. Maehara

    British Journal of Surgery   98 ( 2 )   261 - 267   2011.2

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    DOI: 10.1002/bjs.7311

  • Performance of radiological methods in diagnosing hepatocellular carcinoma preoperatively in a recipient of living related liver transplantation: comparison with step section histopathology.

    Masakazu Hirakawa, Kengo Yoshimitsu, Hiroyuki Irie, Tsuyoshi Tajima, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Akinobu Taketomi, Shin-ichi Aishima, Hiroshi Honda

    Japanese journal of radiology   29 ( 2 )   129 - 37   2011.2

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    DOI: 10.1007/s11604-010-0528-8

  • Pseudo-Meigs' syndrome associated with breast cancer metastasis to both ovaries: Report of a case.

    Naonori Kawakubo, Masayuki Okido, Risa Tanaka, Kenji Mitsugi, Masao Fukuhara, Shinichi Aishima, Masato Kato, Hitoshi Ichimiya

    Surgery today   40 ( 12 )   1148 - 51   2010.12

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    DOI: 10.1007/s00595-009-4187-2

  • Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type. International journal

    24 ( 6 )   1569 - 76   2010.12

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    Ovarian mucinous neoplasms of gastro-intestinal type (GI-type) are known to be a heterogeneous tumor composed of benign, borderline and non-invasive and invasive malignant lesions. The presence of infiltrative invasion is also known to be an important prognostic factor of this neoplasm. Laminin γ 2 chain, known to stimulate tumor cell invasion and migration, has not been sufficiently investigated in ovarian mucinous neoplasms. The purpose of this study was thus to clarify the role of laminin γ 2 in ovarian mucinous neoplasms of GI-type. We selected each morphological phase of tumor development from 61 cases of mucinous neoplasms of the GI-type: 55 adenoma lesions, 60 borderline lesions, 20 microinvasive lesions, 17 intraepithelial carcinoma lesions, 38 expansile invasive carcinoma lesions, 19 infiltrative invasive carcinoma lesions and 5 mural nodules lesions; and evaluated the localization of laminin γ 2 in the lesions using immunohistochemical method. The staining pattern was classified into i) basement membranous (BM), ii) cytoplasmic (CYT) and iii) stromal (S) pattern. The BM pattern was characteristic in adenoma, borderline, and interaepithelial and expansile invasive carcinoma lesions. The CYT and S patterns were characteristic in infiltrative invasive lesions. The staining pattern of mural nodules was similar to that of infiltrative invasion. The infiltrative invasion of GI-type ovarian mucinous neoplasms may be promoted by cytoplasmic and/or stromal expression of laminin γ 2 chain.

    DOI: 10.3892/or-00001019

  • Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation. International journal

    Akifumi Hayashi, Shinichi Aishima, Yoshihiro Miyasaka, Kohei Nakata, Katsuya Morimatsu, Yasunori Oda, Eishi Nagai, Yoshinao Oda, Masao Tanaka, Masazumi Tsuneyoshi

    Human pathology   41 ( 11 )   1507 - 15   2010.11

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    DOI: 10.1016/j.humpath.2010.02.019

  • 抗核抗体高値が持続し短期間に無菌性髄膜炎を反復した亜急性壊死性リンパ節炎の1例

    山下 泰治, 柴田 憲一, 長野 祐久, 相島 慎一, 由村 健夫

    臨床神経学   50 ( 10 )   728 - 31   2010.10

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    症例は35歳女性である.母に関節リウマチ,妹にシェーグレン症候群がある.1年半の間にリンパ節腫張にひき続く無菌性髄膜炎を3回くりかえした.3回目で頸部リンパ節生検をおこない亜急性壊死性リンパ節炎の所見をえた.非ステロイド系消炎鎮痛薬に対する反応は不良であったが,ステロイド投与後に発熱,頭痛,リンパ節腫張はすみやかに改善した.初回入院時から抗核抗体,抗SS-A抗体陽性は持続しており,とくに抗核抗体は再発の度に抗体価が上昇した.亜急性壊死性リンパ節炎は一般的に数カ月以内に自然治癒する予後良好な疾患で,自己抗体の出現も一過性が多い.本例のように無菌性髄膜炎をくりかえすばあいには,自己免疫異常の持続が一因と考えられる.

    DOI: 10.5692/clinicalneurol.50.728, 10.2169/internalmedicine.6494-20_references_DOI_AwNa6llXZ9j97b8W8s8agGc86kC

  • Predictors of extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma. International journal

    Akinobu Taketomi, Takeo Toshima, Dai Kitagawa, Takashi Motomura, Kazuki Takeishi, Yohei Mano, Hiroto Kayashima, Keishi Sugimachi, Shinichi Aishima, Yoichi Yamashita, Toru Ikegami, Tomonobu Gion, Hideaki Uchiyama, Yuji Soejima, Takashi Maeda, Ken Shirabe, Yoshihiko Maehara

    Annals of surgical oncology   17 ( 10 )   2740 - 6   2010.10

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    DOI: 10.1245/s10434-010-1076-2

  • p62+ Hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease. International journal

    Shinichi Aishima, Nobuhiro Fujita, Yohei Mano, Tomohiro Iguchi, Akinobu Taketomi, Yoshihiko Maehara, Yoshinao Oda, Masazumi Tsuneyoshi

    American journal of clinical pathology   134 ( 3 )   457 - 65   2010.9

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    DOI: 10.1309/AJCP53YVVJCNDZIR

  • Imaging of cholangiolocellular carcinoma of the liver. International journal

    Yoshiki Asayama, Tsuyoshi Tajima, Daisuke Okamoto, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Daisuke Kakihara, Shinichi Aishima, Akinobu Taketomi, Hiroshi Honda

    European journal of radiology   75 ( 1 )   e120-5   2010.7

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    DOI: 10.1016/j.ejrad.2009.09.010

  • Clinicopathological prognostic factors after hepatectomy for patients with mass-forming type intrahepatic cholangiocarcinoma: relevance of the lymphatic invasion index. International journal

    Ken Shirabe, Yohei Mano, Akinobu Taketomi, Yuji Soejima, Hideaki Uchiyama, Shinichi Aishima, Hiroto Kayashima, Mizuki Ninomiya, Yoshihiko Maehara

    Annals of surgical oncology   17 ( 7 )   1816 - 22   2010.7

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    DOI: 10.1245/s10434-010-0929-z

  • S100P is a novel marker to identify intraductal papillary mucinous neoplasms. International journal

    Kohei Nakata, Eishi Nagai, Kenoki Ohuchida, Akifumi Hayashi, Yoshihiro Miyasaka, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi

    Human pathology   41 ( 6 )   824 - 31   2010.6

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    DOI: 10.1016/j.humpath.2009.11.007

  • Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinoma. International journal

    Akifumi Hayashi, Shinichi Aishima, Takahiro Inoue, Kohei Nakata, Katsuya Morimatsu, Eishi Nagai, Yoshinao Oda, Masao Tanaka, Masazumi Tsuneyoshi

    Human pathology   41 ( 6 )   859 - 66   2010.6

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    DOI: 10.1016/j.humpath.2009.09.018

  • Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development. International journal

    Nobuhiro Fujita, Shinichi Aishima, Tomohiro Iguchi, Yunosuke Nishihara, Hidetaka Yamamoto, Akinobu Taketomi, Yoshinao Oda, Hiroshi Honda, Masazumi Tsuneyoshi

    Human pathology   41 ( 6 )   838 - 47   2010.6

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    DOI: 10.1016/j.humpath.2009.11.011

  • Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from the intestinal type. International journal

    Yoshihiko Sadakari, Kenoki Ohuchida, Kohei Nakata, Takao Ohtsuka, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

    Surgery   147 ( 6 )   812 - 7   2010.6

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    DOI: 10.1016/j.surg.2009.11.011

  • Sclerosed hemangioma of the liver: possible diagnostic value of diffusion-weighted magnetic resonance imaging.

    Tomoyuki Hida, Akihiro Nishie, Tsuyoshi Tajima, Akinobu Taketomi, Shin-ichi Aishima, Hiroshi Honda

    Japanese journal of radiology   28 ( 3 )   235 - 8   2010.4

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    DOI: 10.1007/s11604-009-0407-3

  • Unusual multiple gastric carcinoids with hypergastrinemia: report of a case.

    Kohei Nakata, Shinichi Aishima, Hitoshi Ichimiya, Takashi Yao, Takashi Matsuura, Mitsuru Seo, Eishi Nagai, Masayuki Okido, Masato Kato, Mitsuru Nakagaki, Masazumi Tsuneyoshi, Masao Tanaka

    Surgery today   40 ( 3 )   267 - 71   2010.3

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    DOI: 10.1007/s00595-009-4032-7

  • Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement. International journal

    Yasuni Nakanuma, Yoh Zen, Kenichi Harada, Motoko Sasaki, Akitaka Nonomura, Takeshi Uehara, Kenji Sano, Fukuo Kondo, Toshio Fukusato, Koichi Tsuneyama, Masahiro Ito, Kenichi Wakasa, Minoru Nomoto, Hiroshi Minato, Hironori Haga, Masayoshi Kage, Hirohisa Yano, Joji Haratake, Shinichi Aishima, Tomoyuki Masuda, Hajime Aoyama, Aya Miyakawa-Hayashino, Toshiharu Matsumoto, Hayato Sanefuji, Hidenori Ojima, Tse-Ching Chen, Eunsil Yu, Ji-Hun Kim, Young Nyun Park, Wilson Tsui

    Pathology international   60 ( 3 )   167 - 74   2010.3

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    DOI: 10.1111/j.1440-1827.2009.02500.x

  • Fascin expression in progression and prognosis of hepatocellular carcinoma. International journal

    Tomohiro Iguchi, Shinichi Aishima, Kenji Umeda, Kensaku Sanefuji, Nobuhiro Fujita, Keishi Sugimachi, Tomonobu Gion, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Journal of surgical oncology   100 ( 7 )   575 - 9   2009.12

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    DOI: 10.1002/jso.21377

  • CD10+ fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma. International journal

    Yunosuke Nishihara, Shinichi Aishima, Akifumi Hayashi, Tomohiro Iguchi, Nobuhiro Fujita, Akinobu Taketomi, Hiroshi Honda, Masazumi Tsuneyoshi

    Histopathology   55 ( 4 )   423 - 31   2009.10

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    DOI: 10.1111/j.1365-2559.2009.03398.x

  • Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic study. International journal

    Hidetaka Yamamoto, Hiroshi Yamaguchi, Shinichi Aishima, Yoshinao Oda, Kenichi Kohashi, Yumi Oshiro, Masazumi Tsuneyoshi

    The American journal of surgical pathology   33 ( 9 )   1330 - 40   2009.9

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    DOI: 10.1097/PAS.0b013e3181a5a207

  • Both fibrous capsule formation and extracapsular penetration are powerful predictors of poor survival in human hepatocellular carcinoma: a histological assessment of 365 patients in Japan. International journal

    Tomohiro Iguchi, Shinichi Aishima, Kensaku Sanefuji, Nobuhiro Fujita, Keishi Sugimachi, Tomonobu Gion, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Annals of surgical oncology   16 ( 9 )   2539 - 46   2009.9

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    DOI: 10.1245/s10434-009-0453-1

  • LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer. International journal

    Kohei Nakata, Kenoki Ohuchida, Eishi Nagai, Akifumi Hayashi, Yoshihiro Miyasaka, Tadashi Kayashima, Jun Yu, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi

    Neoplasia (New York, N.Y.)   11 ( 7 )   712 - 9   2009.7

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    DOI: 10.1593/neo.09418

  • Erratum: Extracapsular penetration is a new prognostic factor in human hepatocellular carcinoma (American Journal of Surgical Pathology (2008) 32 (1675-1682))

    T. Iguchi, S. Aishima, A. Taketomi

    American Journal of Surgical Pathology   33 ( 3 )   485   2009.3

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    DOI: 10.1097/PAS.0b013e31819f584d

  • Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma. International journal

    Shinichi Aishima, Tomohiro Iguchi, Yunosuke Nishihara, Nobuhiro Fujita, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Histopathology   54 ( 4 )   452 - 61   2009.3

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    DOI: 10.1111/j.1365-2559.2009.03240.x

  • Fascin overexpression is involved in carcinogenesis and prognosis of human intrahepatic cholangiocarcinoma: immunohistochemical and molecular analysis. International journal

    Tomohiro Iguchi, Shinichi Aishima, Akinobu Taketomi, Yunosuke Nishihara, Nobuhiro Fujita, Kensaku Sanefuji, Keishi Sugimachi, Yo-ichi Yamashita, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Human pathology   40 ( 2 )   174 - 80   2009.2

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    DOI: 10.1016/j.humpath.2008.06.029

  • ヒト悪性腫瘍の病理組織形態と分子生物学的特性

    恒吉 正澄, 八尾 隆史, 小田 義直, 田宮 貞史, 相島 慎一, 山元 英崇, 大石 善丈, 平橋 美奈子, 栗原 秀一, 孝橋 賢一

    福岡醫學雜誌   100 ( 1 )   13 - 25   2009.1

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    DOI: 10.15017/13540

  • Biliary phenotype of hepatocellular carcinoma after preoperative transcatheter arterial chemoembolization. International journal

    Yunosuke Nishihara, Shinichi Aishima, Yousuke Kuroda, Tomohiro Iguchi, Kenichi Taguchi, Yoshiki Asayama, Akinobu Taketomi, Naoko Kinukawa, Hiroshi Honda, Masazumi Tsuneyoshi

    Journal of gastroenterology and hepatology   23 ( 12 )   1860 - 8   2008.12

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    DOI: 10.1111/j.1440-1746.2008.05601.x

  • Extracapsular penetration is a new prognostic factor in human hepatocellular carcinoma. International journal

    Tomohiro Iguchi, Shinichi Aishima, Akinobu Taketomi, Yunosuke Nishihara, Nobuhiro Fujita, Kensaku Sanefuji, Yoshihiko Maehara, Masazumi Tsuneyoshi

    The American journal of surgical pathology   32 ( 11 )   1675 - 82   2008.11

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    DOI: 10.1097/PAS.0b013e31817a8ed5

  • CD10 immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium. International journal

    Yoshihiro Ohishi, Tsunehisa Kaku, Hiroaki Kobayashi, Shinichi Aishima, Yoshihisa Umekita, Norio Wake, Masazumi Tsuneyoshi

    Human pathology   39 ( 10 )   1446 - 53   2008.10

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    DOI: 10.1016/j.humpath.2008.02.006

  • Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia. International journal

    Shinichi Aishima, Yunosuke Nishihara, Eiji Tsujita, Kenichi Taguchi, Yuji Soejima, Akinobu Taketomi, Yasuharu Ikeda, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Human pathology   39 ( 6 )   939 - 47   2008.6

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    DOI: 10.1016/j.humpath.2007.10.031

  • Adenomatoid tumour of the liver

    S. Nagata, S. Aishima, K. Fukuzawa, H. Takagi, H. Yonemasu, Y. Iwashita, T. Kinoshita, K. Wakasugi

    Journal of Clinical Pathology   61 ( 6 )   777 - 780   2008.6

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    DOI: 10.1136/jcp.2007.054684

  • Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma. International journal

    Shinichi Aishima, Yunosuke Nishihara, Tomohiro Iguchi, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc   21 ( 3 )   256 - 64   2008.3

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    DOI: 10.1038/modpathol.3800985

  • Arterial blood supply of hepatocellular carcinoma and histologic grading: radiologic-pathologic correlation. International journal

    Yoshiki Asayama, Kengo Yoshimitsu, Yunosuke Nishihara, Hiroyuki Irie, Shinichi Aishima, Akinobu Taketomi, Hiroshi Honda

    AJR. American journal of roentgenology   190 ( 1 )   W28-34   2008.1

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    DOI: 10.2214/AJR.07.2117

  • Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine. International journal

    Nobito Higuchi, Masaki Kato, Kazuhiro Kotoh, Motoyuki Kohjima, Shinichi Aishima, Makoto Nakamuta, Yoshinori Fukui, Ryoichi Takayanagi, Munechika Enjoji

    Liver international : official journal of the International Association for the Study of the Liver   27 ( 10 )   1342 - 8   2007.12

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    DOI: 10.1111/j.1478-3231.2007.01590.x

  • Down-regulation of aquaporin-1 in intrahepatic cholangiocarcinoma is related to tumor progression and mucin expression. International journal

    Shinichi Aishima, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Tomohiro Iguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Human pathology   38 ( 12 )   1819 - 25   2007.12

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    DOI: 10.1016/j.humpath.2007.04.016

  • Expression profile of class I histone deacetylases in human cancer tissues. International journal

    Masamune Nakagawa, Yoshinao Oda, Takashi Eguchi, Shin-Ichi Aishima, Takashi Yao, Fumihito Hosoi, Yuji Basaki, Mayumi Ono, Michihiko Kuwano, Masao Tanaka, Masazumi Tsuneyoshi

    Oncology reports   18 ( 4 )   769 - 74   2007.10

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    DOI: 10.3892/or.18.4.769

  • Mucin-hypersecreting bile duct neoplasm characterized by clinicopathological resemblance to intraductal papillary mucinous neoplasm (IPMN) of the pancreas. International journal

    Yo-Ichi Yamashita, Kengo Fukuzawa, Akinobu Taketomi, Shinichi Aishima, Tomoharu Yoshizumi, Hideaki Uchiyama, Eiji Tsujita, Norifumi Harimoto, Noboru Harada, Kenzo Wakasugi, Yoshihiko Maehara

    World journal of surgical oncology   5   98 - 98   2007.8

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    DOI: 10.1186/1477-7819-5-98

  • Role of growth factor receptor bound protein 7 in hepatocellular carcinoma. International journal

    Shinji Itoh, Akinobu Taketomi, Shinji Tanaka, Norifumi Harimoto, Yo-ichi Yamashita, Shin-ichi Aishima, Takashi Maeda, Ken Shirabe, Mitsuo Shimada, Yoshihiko Maehara

    Molecular cancer research : MCR   5 ( 7 )   667 - 73   2007.7

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    DOI: 10.1158/1541-7786.MCR-06-0282

  • Proposal of progression model for intrahepatic cholangiocarcinoma: clinicopathologic differences between hilar type and peripheral type. International journal

    Shinichi Aishima, Yousuke Kuroda, Yunosuke Nishihara, Tomohiro Iguchi, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    The American journal of surgical pathology   31 ( 7 )   1059 - 67   2007.7

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    DOI: 10.1097/PAS.0b013e31802b34b6

  • 14-3-3sigma negatively regulates the cell cycle, and its down-regulation is associated with poor outcome in intrahepatic cholangiocarcinoma. International journal

    Yousuke Kuroda, Shinichi Aishima, Akinobu Taketomi, Yunosuke Nishihara, Tomohiro Iguchi, Kenichi Taguchi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Human pathology   38 ( 7 )   1014 - 1022   2007.7

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    DOI: 10.1016/j.humpath.2006.12.014

  • Hepatoid adenocarcinoma of the stomach: histogenesis and progression in association with intestinal phenotype. International journal

    Yumiko Kumashiro, Takashi Yao, Shinichi Aishima, Minako Hirahashi, Kenichi Nishiyama, Tomomi Yamada, Ryoichi Takayanagi, Masazumi Tsuneyoshi

    Human pathology   38 ( 6 )   857 - 63   2007.6

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    DOI: 10.1016/j.humpath.2006.10.020

  • Histologic characteristics and prognostic significance in small hepatocellular carcinoma with biliary differentiation: subdivision and comparison with ordinary hepatocellular carcinoma. International journal

    Shinichi Aishima, Yunosuke Nishihara, Yousuke Kuroda, Kenichi Taguchi, Tomohiro Iguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    The American journal of surgical pathology   31 ( 5 )   783 - 91   2007.5

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    DOI: 10.1097/01.pas.0000213421.53750.0a

  • Extended indication for living donor liver transplantation in patients with hepatocellular carcinoma

    Yuji Soejima, Akinobu Taketomi, Tomoharu Yoshizumi, Hideaki Uchiyama, Shinich Aishima, Takahiro Terashi, Mitsuo Shimada, Yoshihiko Maehara

    Transplantation   83 ( 7 )   893 - 899   2007.4

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    DOI: 10.1097/01.tp.0000259015.46798.ec

  • The predictors of microvascular invasion in candidates for liver transplantation with hepatocellular carcinoma-with special reference to the serum levels of des-gamma-carboxy prothrombin. International journal

    Ken Shirabe, Shinji Itoh, Tomoharu Yoshizumi, Yuji Soejima, Akinobu Taketomi, Shin-Ichi Aishima, Yoshihiko Maehara

    Journal of surgical oncology   95 ( 3 )   235 - 40   2007.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jso.20655

  • A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease. International journal

    Tohru Utsunomiya, Masahiro Okamoto, Shigeki Wakiyama, Masaji Hashimoto, Kengo Fukuzawa, Takahiro Ezaki, Shinichi Aishima, Yasuji Yoshikawa, Taizo Hanai, Hiroshi Inoue, Graham-F Barnard, Masaki Mori

    World journal of gastroenterology   13 ( 3 )   383 - 90   2007.1

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    DOI: 10.3748/wjg.v13.i3.383

  • Proposal of a new staging and grading system of the liver for primary biliary cirrhosis

    K. Hiramatsu, H. Aoyama, Y. Zen, S. Aishima, S. Kitagawa, Y. Nakanuma

    Histopathology   49 ( 5 )   466 - 478   2006.11

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    DOI: 10.1111/j.1365-2559.2006.02537.x

  • Characteristic differences according to the cirrhotic pattern of advanced primary biliary cirrhosis: Macronodular cirrhosis indicates slow progression. International journal

    Shinichi Aishima, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Hepatology research : the official journal of the Japan Society of Hepatology   36 ( 3 )   188 - 94   2006.11

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    DOI: 10.1016/j.hepres.2006.07.008

  • High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma. International journal

    Shinichi Aishima, Yuji Basaki, Yoshinao Oda, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Fumihito Hosoi, Yuichiro Maruyama, Abbas Fotovati, Shinji Oie, Mayumi Ono, Takato Ueno, Michio Sata, Hirohisa Yano, Masamichi Kojiro, Michihiko Kuwano, Masazumi Tsuneyoshi

    Cancer science   97 ( 11 )   1182 - 90   2006.11

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    DOI: 10.1111/j.1349-7006.2006.00322.x

  • Hepatocellular carcinoma with a prominent vascular scar in the center: MR imaging findings.

    Madoka Yamauchi, Yoshiki Asayama, Kengo Yoshimitsu, Hiroyuki Irie, Tsuyoshi Tajima, Masakazu Hirakawa, Kousei Ishigami, Tomohiro Nakayama, Daisuke Kakihara, Koji Yamaguchi, Yunosuke Nishihara, Shinichi Aishima, Hiroshi Honda

    Radiation medicine   24 ( 6 )   467 - 70   2006.7

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    DOI: 10.1007/s11604-006-0052-z

  • Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: Gastric foveolar type is associated with aggressive tumour behaviour

    S. Aishima, Y. Kuroda, Y. Nishihara, K. Taguchi, A. Taketomi, Y. Maehara, M. Tsuneyoshi

    Histopathology   49 ( 1 )   35 - 44   2006.7

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    DOI: 10.1111/j.1365-2559.2006.02414.x

  • Prognostic impact of cholangiocellular and sarcomatous components in combined hepatocellular and cholangiocarcinoma. International journal

    Shinichi Aishima, Yousuke Kuroda, Yoshiki Asayama, Kenichi Taguchi, Yunosuke Nishihara, Akinobu Taketomi, Masazumi Tsuneyoshi

    Human pathology   37 ( 3 )   283 - 91   2006.3

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    DOI: 10.1016/j.humpath.2005.08.019

  • Delayed-phase dynamic CT enhancement as a prognostic factor for mass-forming intrahepatic cholangiocarcinoma. International journal

    Yoshiki Asayama, Kengo Yoshimitsu, Hiroyuki Irie, Tsuyoshi Tajima, Akihiro Nishie, Masakazu Hirakawa, Tomohiro Nakayama, Daisuke Kakihara, Akinobu Taketomi, Shin-ichi Aishima, Hiroshi Honda

    Radiology   238 ( 1 )   150 - 5   2006.1

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    DOI: 10.1148/radiol.2381041765

  • [Mechanism of biliary carcinogenesis: Hepatotropic hepatis virus].

    Kenichi Taguchi, Shinichi Aishima, Masazumi Tsuneyoshi

    Nihon rinsho. Japanese journal of clinical medicine   64 Suppl 1   362 - 5   2006.1

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  • Significance of the relationship between irregular regeneration and two hepatocarcinogenic pathways: "de novo" and so-called "dysplastic nodule-hepatocellular carcinoma" sequence. International journal

    Kenichi Taguchi, Shinichi Aishima, Shuji Matsuura, Takahiro Terashi, Kenichi Nishiyama, Ken Shirabe, Mitsuo Shimada, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Journal of surgical oncology   92 ( 2 )   100 - 3   2005.11

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    DOI: 10.1002/jso.20293

  • サイトメガロウイルス感染症と出血性直腸潰瘍を合併した成人スチル病の1例

    檜沢 一興, 相島 慎一, 八尾 隆史, 中原 束, 松本 主之, 飯田 三雄

    日本消化器病学会雑誌   102 ( 10 )   1281 - 5   2005.10

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    症例は84歳女性.成人スチル病の診断でステロイド治療中に大量下血を生じ,2003年6月4日,当科緊急入院となった.直腸に巨大潰瘍あり,生検組織像にて虚血性変化と薬剤性粘膜障害の所見を認めた.さらにCMVantigenemia陽性のためgancyclovir併用し,中心静脈栄養療法を継続した.経過中antigenemia再上昇にともない下血が再燃した.gancyclovir継続後は下血なく,2004年3月16日,成人スチル病のため死亡した.

    DOI: 10.11405/nisshoshi.102.1281

  • 'Scirrhous' type hepatocellular carcinomas: A special reference to expression of cytokeratin 7 and hepatocyte paraffin 1

    S. Matsuura, S. Aishima, K. Taguchi, Y. Asayama, T. Terashi, H. Honda, Masazumi Tsuneyoshi

    Histopathology   47 ( 4 )   382 - 390   2005.10

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    DOI: 10.1111/j.1365-2559.2005.02230.x

  • Short-term intensive treatment for donors with hepatic steatosis in living-donor liver transplantation

    Makoto Nakamuta, Shusuke Morizono, Yuji Soejima, Tomoharau Yoshizumi, Shinji Aishima, Shin Ichiro Takasugi, Kengo Yoshimitsu, Munechika Enjoji, Kazuhiro Kotoh, Akinobu Taketomi, Hideaki Uchiyama, Mitsuo Shimada, Hajime Nawata, Yoshihiko Maehara

    Transplantation   80 ( 5 )   608 - 612   2005.9

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    DOI: 10.1097/01.tp.0000166009.77444.f3

  • Bronchiolitis obliterans organizing pneumonia as an initial manifestation in systemic lupus erythematosus. International journal

    Hidetoshi Takada, Yusuke Saito, Akihiko Nomura, Shouichi Ohga, Kazuyoshi Kuwano, Nobutaka Nakashima, Shinichi Aishima, Noboru Tsuru, Toshiro Hara

    Pediatric pulmonology   40 ( 3 )   257 - 60   2005.9

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    DOI: 10.1002/ppul.20224

  • Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement. International journal

    Yoh Zen, Shinichi Aishima, Yoichi Ajioka, Joji Haratake, Masayoshi Kage, Fukuo Kondo, Yuji Nimura, Michiie Sakamoto, Motoko Sasaki, Kazuhide Shimamatsu, Kenichi Wakasa, Young Nyun Park, Ming F Chen, Yutaka Atomi, Yasuni Nakanuma

    Pathology international   55 ( 4 )   180 - 8   2005.4

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    DOI: 10.1111/j.1440-1827.2005.01816.x

  • Detection of combined hepatocellular and cholangiocarcinomas on enhanced CT: comparison with histologic findings. International journal

    Akihiro Nishie, Kengo Yoshimitsu, Yoshiki Asayama, Hiroyuki Irie, Hitoshi Aibe, Tsuyoshi Tajima, Kenji Shinozaki, Tomohiro Nakayama, Daisuke Kakihara, Mitsuo Shimada, Shin-Ichi Aishima, Kisaku Yoshida, Hiroshi Honda

    AJR. American journal of roentgenology   184 ( 4 )   1157 - 62   2005.4

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    DOI: 10.2214/ajr.184.4.01841157

  • バルプロ酸ナトリウムにより高アンモニア血症をきたしたC型慢性肝炎の1例

    福嶋 真理恵, 古藤 和浩, 遠城寺 宗近, 中牟田 誠, 名和田 新, 相島 慎一

    日本消化器病学会雑誌   102 ( 1 )   42 - 7   2005.1

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    症例は45歳,男性.平成10年より慢性硬膜血腫術後のてんかん発作にて,近医経過観察中,高アンモニア血症を指摘され,平成13年5月当科に紹介入院.HCV-RNA陽性だが肝予備能低下なく,門脈大循環へのシャントなく,アミノ酸分析正常であった.薬剤の関与としてバルプロ酸ナトリウムが考えられ,減量中止したところアンモニア値は改善した.基礎病変として肝疾患を持つ症例においても,常に薬剤による高アンモニア血症に考慮して診療にあたるべきと考えられた.

    DOI: 10.11405/nisshoshi.102.42, 10.2957/kanzo.59.421_references_DOI_7iqc9gI6LrFzakFaQecy4g2pG30

  • The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C. International journal

    Norifumi Harimoto, Mitsuo Shimada, Shin-ichi Aishima, Dai Kitagawa, Shinji Itoh, Eiji Tsujita, Shin-ichiro Maehara, Akinobu Taketomi, Shinji Tanaka, Ken Shirabe, Yoshihiko Maehara

    Liver international : official journal of the International Association for the Study of the Liver   24 ( 4 )   316 - 21   2004.8

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    DOI: 10.1111/j.1478-3231.2004.0927.x

  • The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C. International journal

    Norifumi Harimoto, Mitsuo Shimada, Shin-ichi Aishima, Dai Kitagawa, Shinji Itoh, Eiji Tsujita, Shin-ichiro Maehara, Akinobu Taketomi, Shinji Tanaka, Ken Shirabe, Yoshihiko Maehara

    Liver international : official journal of the International Association for the Study of the Liver   24 ( 4 )   316 - 21   2004.8

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    DOI: 10.1111/j.1478-3231.2004.0927.x

  • Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. International journal

    Shinji Itoh, Takashi Maeda, Mitsuo Shimada, Shin-ichi Aishima, Ken Shirabe, Shinji Tanaka, Yoshihiko Maehara

    Clinical cancer research : an official journal of the American Association for Cancer Research   10 ( 8 )   2812 - 7   2004.4

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    DOI: 10.1158/1078-0432.CCR-1046-03

  • Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis. International journal

    Ken Shirabe, Mitsuo Shimada, Eiji Tsujita, Shin-ichi Aishima, Shin-ichiroh Maehara, Sinji Tanaka, Kenji Takenaka, Yoshihiko Maehara

    American journal of surgery   187 ( 4 )   538 - 42   2004.4

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    DOI: 10.1016/j.amjsurg.2003.12.044

  • Decreased expression of osteopontin is related to tumor aggressiveness and clinical outcome of intrahepatic cholangiocarcinoma. International journal

    Takahiro Terashi, Shinichi Aishima, Kenichi Taguchi, Yoshiki Asayama, Keishi Sugimachi, Shuji Matsuura, Mitsuo Shimada, Shinichiro Maehara, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Liver international : official journal of the International Association for the Study of the Liver   24 ( 1 )   38 - 45   2004.2

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    DOI: 10.1111/j.1478-3231.2004.00886.x

  • Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma

    K. Sugimachi, S. Tanaka, K. Taguchi, S. Aishima, M. Shimada, K. Sugimachi, M. Tsuneyoshi

    Journal of Clinical Pathology   56 ( 11 )   854 - 860   2003.11

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    DOI: 10.1136/jcp.56.11.854

  • Tenascin expression at the invasive front is associated with poor prognosis in intrahepatic cholangiocarcinoma. International journal

    Shin-Ichi Aishima, Ken-Ichi Taguchi, Takahiro Terashi, Shuji Matsuura, Mitsuo Shimada, Masazumi Tsuneyoshi

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc   16 ( 10 )   1019 - 27   2003.10

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    DOI: 10.1097/01.MP.0000086860.65672.73

  • Tenascin expression at the invasive front is associated with poor prognosis in intrahepatic cholangiocarcinoma. International journal

    Shin-Ichi Aishima, Ken-Ichi Taguchi, Takahiro Terashi, Shuji Matsuura, Mitsuo Shimada, Masazumi Tsuneyoshi

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc   16 ( 10 )   1019 - 27   2003.10

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    DOI: 10.1097/01.MP.0000086860.65672.73

  • Transcriptional repressor snail and progression of human hepatocellular carcinoma. International journal

    Keishi Sugimachi, Shinji Tanaka, Toshifumi Kameyama, Ken-ichi Taguchi, Shin-ichi Aishima, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

    Clinical cancer research : an official journal of the American Association for Cancer Research   9 ( 7 )   2657 - 64   2003.7

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  • Transcriptional repressor snail and progression of human hepatocellular carcinoma. International journal

    Keishi Sugimachi, Shinji Tanaka, Toshifumi Kameyama, Ken-ichi Taguchi, Shin-ichi Aishima, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

    Clinical cancer research : an official journal of the American Association for Cancer Research   9 ( 7 )   2657 - 64   2003.7

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  • Sarcomatous hepatocellular carcinoma: a special reference to ordinary hepatocellular carcinoma. International journal

    Hidehiro Nishi, Ken-ichi Taguchi, Yoshiki Asayama, Shin-ichi Aishima, Keishi Sugimachi, Hajime Nawata, Masazumi Tsuneyoshi

    Journal of gastroenterology and hepatology   18 ( 4 )   415 - 23   2003.4

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    DOI: 10.1046/j.1440-1746.2003.02888.x

  • Sarcomatous hepatocellular carcinoma: a special reference to ordinary hepatocellular carcinoma. International journal

    Hidehiro Nishi, Ken-ichi Taguchi, Yoshiki Asayama, Shin-ichi Aishima, Keishi Sugimachi, Hajime Nawata, Masazumi Tsuneyoshi

    Journal of gastroenterology and hepatology   18 ( 4 )   415 - 23   2003.4

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    DOI: 10.1046/j.1440-1746.2003.02888.x

  • The utility of keratin 903 as a new prognostic marker in mass-forming-type intrahepatic cholangiocarcinoma. International journal

    Shin-Ichi Aishima, Yoshiki Asayama, Ken-Ichi Taguchi, Keishi Sugimachi, Ken Shirabe, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc   15 ( 11 )   1181 - 90   2002.11

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    DOI: 10.1097/01.MP.0000032537.82380.69

  • The utility of keratin 903 as a new prognostic marker in mass-forming-type intrahepatic cholangiocarcinoma. International journal

    Shin-Ichi Aishima, Yoshiki Asayama, Ken-Ichi Taguchi, Keishi Sugimachi, Ken Shirabe, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc   15 ( 11 )   1181 - 90   2002.11

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    DOI: 10.1097/01.MP.0000032537.82380.69

  • Coexpression of neural cell adhesion molecules and bcl-2 in intrahepatic cholangiocarcinoma originated from viral hepatitis: relationship to atypical reactive bile ductule. International journal

    Yoshiki Asayama, Shin-Ichi Aishima, Ken-Ichi Taguchi, Keishi Sugimachi, Shuji Matsuura, Kouji Masuda, Masazumi Tsuneyoshi

    Pathology international   52 ( 4 )   300 - 6   2002.4

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    DOI: 10.1046/j.1440-1827.2002.01349.x

  • Coexpression of neural cell adhesion molecules and bcl-2 in intrahepatic cholangiocarcinoma originated from viral hepatitis: relationship to atypical reactive bile ductule. International journal

    Yoshiki Asayama, Shin-Ichi Aishima, Ken-Ichi Taguchi, Keishi Sugimachi, Shuji Matsuura, Kouji Masuda, Masazumi Tsuneyoshi

    Pathology international   52 ( 4 )   300 - 6   2002.4

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    DOI: 10.1046/j.1440-1827.2002.01349.x

  • The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. International journal

    Shin-ichi Aishima, Ken-ichi Taguchi, Keishi Sugimachi, Yoshiki Asayama, Hidehiro Nishi, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

    International journal of surgical pathology   10 ( 1 )   47 - 56   2002.1

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    DOI: 10.1177/106689690201000108

  • Clinicopathologic risk factors for recurrence after a curative hepatic resection for hepatocellular carcinoma. International journal

    Eisuke Adachi, Shin-ichiro Maehara, Eiji Tsujita, Ken-ichi Taguchi, Shin-ichi Aishima, Tatsuya Rikimaru, Yo-ichi Yamashita, Shinji Tanaka

    Surgery   131 ( 1 Suppl )   S148-52   2002.1

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    DOI: 10.1067/msy.2002.119496

  • Intrahepatic cholangiocarcinoma: its mode of spreading and therapeutic modalities. International journal

    Ken Shirabe, Mitsuo Shimada, Norifumi Harimoto, Keishi Sugimachi, Yo-ichi Yamashita, Eiji Tsujita, Shin-ichi Aishima

    Surgery   131 ( 1 Suppl )   S159-64   2002.1

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    DOI: 10.1067/msy.2002.119498

  • The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. International journal

    Shin-ichi Aishima, Ken-ichi Taguchi, Keishi Sugimachi, Yoshiki Asayama, Hidehiro Nishi, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

    International journal of surgical pathology   10 ( 1 )   47 - 56   2002.1

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    DOI: 10.1177/106689690201000108

  • Clinicopathologic risk factors for recurrence after a curative hepatic resection for hepatocellular carcinoma. International journal

    Eisuke Adachi, Shin-ichiro Maehara, Eiji Tsujita, Ken-ichi Taguchi, Shin-ichi Aishima, Tatsuya Rikimaru, Yo-ichi Yamashita, Shinji Tanaka

    Surgery   131 ( 1 Suppl )   S148-52   2002.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1067/msy.2002.119496

  • Intrahepatic cholangiocarcinoma: its mode of spreading and therapeutic modalities. International journal

    Ken Shirabe, Mitsuo Shimada, Norifumi Harimoto, Keishi Sugimachi, Yo-ichi Yamashita, Eiji Tsujita, Shin-ichi Aishima

    Surgery   131 ( 1 Suppl )   S159-64   2002.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1067/msy.2002.119498

  • S05-04 肝内胆管癌に対する切除の問題点と戦略

    調 憲, 島田 光生, 竹中 賢治, 田中 真二, 山下 洋市, 相島 慎一, 杉町 圭蔵

    日本消化器外科学会雑誌   34 ( 7 )   824   2001.7

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  • The role of des-γ-carboxy prothrombin levels in hepatocellular carcinoma and liver tissues

    159 ( 1 )   87 - 94   2000.10

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    Language:Others   Publishing type:Research paper (scientific journal)  

    We aimed to clarify the clinical significance of des-γ-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC, who underwent hepatectomy, were studied. Surgical specimens were obtained from both HCC and non-cancerous liver of each patient. After the preparation of the liver tissues, including tissues with HCC, the DCP levels both in HCC and non-cancerous liver tissue were measured using an electro-chemiluminescence immunoassay. The correlation was investigated between DCP levels and other clinicopathological factors. The DCP level of HCC ranged from 55 to 77 735 U/0.1 g tissue weight, with a median of 2801, while the DCP level of non-cancerous parts of the liver ranged from 24 to 721 U/0.1 g tissue weight, with a median of 86. The DCP level in the liver tissue in patients having a multicentric occurrence of HCC was significantly higher than that in patients without multicentric occurrence of HCC. The logarithm of the plasma DCP level correlated with that of the DCP level in HCC (correlation coefficient = 0.46; P < 0.05). No significant correlation was found between the DCP level in HCC and other clinicopathological parameters. The DCP level in non-cancerous parts of the liver with simultaneous multicentric occurrence of HCC was significantly higher than that in the liver without multicentric HCC. Furthermore, the DCP level in non-cancerous parts of the liver was one of the most important predictable factors of the multicentric occurrence of HCCs among various clinicopathological factors. Therefore, the DCP level may have an important role in hepatocarcinogenesis. (C) 2000 Elsevier Science Ireland Ltd.

    DOI: 10.1016/S0304-3835(00)00539-5

  • The role of des-γ-carboxy prothrombin levels in hepatocellular carcinoma and liver tissues

    159 ( 1 )   87 - 94   2000.10

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    Language:Others   Publishing type:Research paper (scientific journal)  

    We aimed to clarify the clinical significance of des-γ-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC, who underwent hepatectomy, were studied. Surgical specimens were obtained from both HCC and non-cancerous liver of each patient. After the preparation of the liver tissues, including tissues with HCC, the DCP levels both in HCC and non-cancerous liver tissue were measured using an electro-chemiluminescence immunoassay. The correlation was investigated between DCP levels and other clinicopathological factors. The DCP level of HCC ranged from 55 to 77 735 U/0.1 g tissue weight, with a median of 2801, while the DCP level of non-cancerous parts of the liver ranged from 24 to 721 U/0.1 g tissue weight, with a median of 86. The DCP level in the liver tissue in patients having a multicentric occurrence of HCC was significantly higher than that in patients without multicentric occurrence of HCC. The logarithm of the plasma DCP level correlated with that of the DCP level in HCC (correlation coefficient = 0.46; P < 0.05). No significant correlation was found between the DCP level in HCC and other clinicopathological parameters. The DCP level in non-cancerous parts of the liver with simultaneous multicentric occurrence of HCC was significantly higher than that in the liver without multicentric HCC. Furthermore, the DCP level in non-cancerous parts of the liver was one of the most important predictable factors of the multicentric occurrence of HCCs among various clinicopathological factors. Therefore, the DCP level may have an important role in hepatocarcinogenesis. (C) 2000 Elsevier Science Ireland Ltd.

    DOI: 10.1016/S0304-3835(00)00539-5

  • Clinicopathologic features and postoperative prognosis of multicentric small hepatocellular carcinoma

    Tohru Utsunomiya, Mitsuo Shimada, Ken Ichi Taguchi, Hirofumi Hasegawa, Yoichi Yamashita, Takayuki Hamatsu, Shin Ichi Aishima, Keizo Sugimachi

    Journal of the American College of Surgeons   190 ( 3 )   331 - 335   2000.3

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    DOI: 10.1016/S1072-7515(99)00268-9

  • Clinicopathologic features and postoperative prognosis of multicentric small hepatocellular carcinoma

    Tohru Utsunomiya, Mitsuo Shimada, Ken Ichi Taguchi, Hirofumi Hasegawa, Yoichi Yamashita, Takayuki Hamatsu, Shin Ichi Aishima, Keizo Sugimachi

    Journal of the American College of Surgeons   190 ( 3 )   331 - 335   2000.3

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    DOI: 10.1016/S1072-7515(99)00268-9

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Books

  • わかりやすい病理学

    恒吉, 正澄, 小田, 義直, 相島, 慎一

    南江堂  2021.3 

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    Responsible for pages:総ページ数:19,354p   Language:Japanese  

  • わかりやすい病理学

    小田, 義直, 相島, 慎一, 恒吉, 正澄

    南江堂  2021.3 

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    Responsible for pages:総ページ数:xix, 354p   Language:Japanese  

Presentations

  • 系統的病理診断講習会2 胆道系疾患の病理 Invited

    相島慎一

    第113回日本病理学会総会  2024.4 

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    Event date: 2024.4 - 2024.5

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:名古屋(WEB配信)   Country:Japan  

    胆道系疾患の病理診断に関して解説する(オンデマンド配信 60分)

  • 肝胆道癌の病理学的分類と遺伝子検査 Invited

    相島慎一

    第5回肝胆膵外科制癌治療研究会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京都中央区日本橋   Country:Japan  

  • 肝胆膵領域の病理学の現状とこれから Invited

    相島慎一

    2024.1 

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    Event date: 2024.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ホテルニューオータニ博多   Country:Japan  

  • 肝胆道領域の病理診断 Invited

    相島 慎一

    第62回日本臨床細胞学会秋期大会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 微小脈管侵襲の病理診断

    相島 慎一

    第59回肝癌研究会  2023.7 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪府   Country:Japan  

MISC

  • 奈良宣言(ALT over 30)のMASLD(metabolic dysfunction-associated steatotic liver disease)における臨床的意義の検証

    川中 美和, 藤井 英樹, 岩城 慶大, 林 秀樹, 豊田 秀徳, 大枝 敏, 兵庫 秀幸, 森下 朝洋, 宗景 玄祐, 川田 一仁, 堤 翼, 澤田 康司, 前城 達次, 飛田 博史, 吉田 雄一, 内藤 雅文, 荒木 亜寿香, 新垣 伸吾, 川口 巧, 則武 秀尚, 小野 正文, 正木 勉, 安田 諭, 冨田 栄一, 米田 正人, 徳重 明央, 鎌田 佳宏, 高橋 宏和, 植田 真一郎, 相島 慎一, 角田 圭雄, 岡上 武, 中島 淳, Japan Study Group of Nonalcoholic Fatty Liver Disease(JSG-NAFLD)

    肝臓   2024.4

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    DOI: 10.2957/kanzo.65.186

  • Validation study of age‐independent fibrosis score (Fibrosis‐3 index) in patients with metabolic dysfunction‐associated steatotic liver disease Reviewed

    2024.4

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    Abstract

    Background and Aims

    Because the accuracy of the Fibrosis‐4 (FIB‐4) index for predicting liver fibrosis changes with age, the need for different cut‐offs in various age groups has frequently been discussed. We developed the age‐independent score, the Fibrosis‐3 (FIB‐3) index, and have shown its usefulness in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). This study aimed to validate the diagnostic ability of the FIB‐3 index to predict fibrosis progression using a large new patient cohort.

    Methods

    The ability of the FIB‐3 index to predict liver fibrosis was analyzed by comparing it with that of the FIB‐4 index using data from 1398 patients with MASLD enrolled in the Asia‐based clinical outcome NAFLD study.

    Results

    The areas under the receiver operating characteristic curves for predicting fibrosis stage F3 or higher were not different between the FIB‐3 and FIB‐4 indices in the entire cohort. Using the single ideal cut‐offs of the indices (3.41 for FIB‐3 index and 2.01 for FIB‐4 index), the predictive accuracy of the FIB‐3 index was not significantly different from that of the FIB‐4 index among patients aged <60 years; however, the accuracy of the FIB‐3 index was significantly higher than that of the FIB‐4 index in those aged ≥60 years (0.645 and 0.529, respectively; p < 0.0001).

    Conclusion

    The high ability of the FIB‐3 index with a single cut‐off to predict liver fibrosis in patients with MASLD was confirmed. The FIB‐3 index could serve as a useful tool for assessing liver fibrosis regardless of age.

    DOI: 10.1111/hepr.14039

  • Accuracy of the Enhanced Liver Fibrosis Test in Patients With Type 2 Diabetes Mellitus and Its Clinical Implications

    Taeang Arai, Hirokazu Takahashi, Yuya Seko, Hidenori Toyoda, Hideki Hayashi, Kanji Yamaguchi, Michihiro Iwaki, Masato Yoneda, Toshihide Shima, Hideki Fujii, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Yuichi Yoshida, Tadashi Ikegami, Kazuo Notsumata, Satoshi Oeda, Masanori Atsukawa, Yoshihiro Kamada, Yoshio Sumida, Hideaki Fukushima, Eiji Miyoshi, Shinichi Aishima, Takeshi Okanoue, Yoshito Itoh, Atsushi Nakajima

    Clinical Gastroenterology and Hepatology   2024.4

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    DOI: 10.1016/j.cgh.2023.11.022

  • Hepatic inflammation and fibrosis are profiles related to mid‐term mortality in biopsy‐proven MASLD: A multicenter study in Japan Reviewed

    2024.4

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    Summary

    Aims

    A multi‐stakeholder consensus has proposed MASLD (metabolic dysfunction‐associated steatotic liver disease). We aimed to investigate the pathological findings related to the mid‐term mortality of patients with biopsy‐proven MASLD in Japan.

    Methods

    We enrolled 1349 patients with biopsy‐proven MASLD. The observational period was 8010 person years. We evaluated independent factors associated with mortality in patients with MASLD by Cox regression analysis. We also investigated pathological profiles related to mortality in patients with MASLD using data‐mining analysis.

    Results

    The prevalence of MASH and stage 3/4 fibrosis was observed in 65.6&#37; and 17.4&#37;, respectively. Forty‐five patients with MASLD died. Of these, liver‐related events were the most common cause at 40&#37; (n = 18), followed by extrahepatic malignancies at 26.7&#37; (n = 12). Grade 2/3 lobular inflammation and stage 3/4 fibrosis had a 1.9‐fold and 1.8‐fold risk of mortality, respectively. In the decision‐tree analysis, the profiles with the worst prognosis were characterised by Grade 2/3 hepatic inflammation, along with advanced ballooning (grade 1/2) and fibrosis (stage 3/4). This profile showed a mortality at 8.3&#37;. Furthermore, the random forest analysis identified that hepatic fibrosis and inflammation were the first and second responsible factors for the mid‐term prognosis of patients with MASLD.

    Conclusions

    In patients with biopsy‐proven MASLD, the prevalence of MASH and advanced fibrosis was approximately 65&#37; and 20&#37;, respectively. The leading cause of mortality was liver‐related events. Hepatic inflammation and fibrosis were significant factors influencing mid‐term mortality. These findings highlight the importance of targeting inflammation and fibrosis in the management of patients with MASLD.

    DOI: 10.1111/apt.17995

  • Interobserver agreement of pathologic classification and grading of tumoral intraductal pre-invasive neoplasms of the bile duct Reviewed

    Yasuni Nakanuma, Yasunori Sato, Yuko Kakuda, Yoshiki Naito, Yuki Fukumura, Mana Fukushima, Hiroshi Minato, Shinichi Aishima, Nobuyuki Ohike, Toru Furukawa

    Annals of Diagnostic Pathology   2024.4

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    DOI: 10.1016/j.anndiagpath.2023.152247

  • Novel method for classification of prion diseases by detecting PrP res signal patterns from formalin-fixed paraffin-embedded samples Reviewed

    Sachiko Koyama, Kaoru Yagita, Hideomi Hamasaki, Hideko Noguchi, Masahiro Shijo, Kosuke Matsuzono, Kei-Ichiro Takase, Keita Kai, Shin-Ichi Aishima, Kyoko Itoh, Toshiharu Ninomiya, Naokazu Sasagasako, Hiroyuki Honda

    Prion   2024.4

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    DOI: 10.1080/19336896.2024.2337981

  • Prognosis of biopsy-confirmed metabolic dysfunction- associated steatotic liver disease: A sub-analysis of the CLIONE study Reviewed

    Michihiro Iwaki, Hideki Fujii, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

    Clinical and Molecular Hepatology   2024.4

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    DOI: 10.3350/cmh.2023.0515

  • A rare case of liver regenerative and non-neoplastic lesion resembling a well-differentiated hepatocellular carcinoma Reviewed

    Kosuke Hirose, Takeo Toshima, Taro Tobo, Satohiro Kai, Masakazu Hirakawa, Satoshi Higuchi, Takashi Ofuchi, Kiyotaka Hosoda, Yusuke Yonemura, Yuichi Hisamatsu, Takaaki Masuda, Shinichi Aishima, Koshi Mimori

    Surgical Case Reports   2024.2

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    DOI: 10.1186/s40792-024-01820-1

  • 肝胆道領域の病理診断

    相島 慎一

    日本臨床細胞学会雑誌   2023.10

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  • 増大号 「胃と腸」式 読影問題集2023 応用と発展-考える画像診断が身につく 全消化管 3 Cases Case 3

    芥川 剛至, 沖井 詩織, 島村 拓弥, 相島 慎一, 江﨑 幹宏

    胃と腸   2023.10

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    DOI: 10.11477/mf.1403203389

  • 胆道上皮内腫瘍と細胞診をめぐる問題 胆道上皮内腫瘍の概念と病理

    相島 慎一

    日本臨床細胞学会雑誌   2021.10

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  • 自己免疫性溶血性貧血を合併した原発性胆汁性胆管炎の2例

    道免 和文, 山本 洋, 山本 麻太郎, 小野原 伸也, 相島 慎一, 下田 慎治

    肝臓   2021.2

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    1例目は71歳,女性.動悸を主訴に当科を紹介受診した.血色素7.7 g/dl,ハプトグロビン10 mg/dl以下,Coombs試験陽性から自己免疫性溶血性貧血(AIHA)と診断された.プレドニゾロン(prednisolone,PSL)投与が著効したが,AIHAの診断後1年8カ月経過した頃よりALP,γGTPの上昇ならびに抗ミトコンドリアM2抗体の高値を示し,肝組織検査で中沼分類stage 2の原発性胆汁性胆管炎(PBC)と診断された.2例目は67歳,男性.褐色尿を主訴に当科を紹介受診した.血色素が10.3 g/dl,ハプトグロビンが10 mg/dl以下,Coombs試験が陽性であり,AIHAと診断された.1例目同様にPSLが著効したが,初診時からの持続的なALP,γGTPの上昇ならびに抗ミトコンドリアM2抗体の高値を示し,肝組織検査で中沼分類stage 2のPBCと診断された.2症例ともにウルソデオキシコール酸が奏効し,肝胆道系酵素は正常化した.自己免疫性疾患であるPBC,AIHAの合併例は稀であり,発症機序,治療について考察した.

    DOI: 10.2957/kanzo.62.144

  • Histopathological findings of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

    Masayoshi Kage, Shinichi Aishima, Hironori Kusano, Hirohisa Yano

    Journal of medical ultrasonics (2001)   2020.10

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    DOI: 10.1007/s10396-020-01061-3

  • Guidance for diagnosing autoimmune pancreatitis with biopsy tissues.

    Kenji Notohara, Terumi Kamisawa, Noriyoshi Fukushima, Toru Furukawa, Takuma Tajiri, Hiroshi Yamaguchi, Shinichi Aishima, Yuki Fukumura, Kenichi Hirabayashi, Eisuke Iwasaki, Atsushi Kanno, Satomi Kasashima, Atsuhiro Kawashima, Motohiro Kojima, Kensuke Kubota, Yasuhiro Kuraishi, Tomoko Mitsuhashi, Yoshiki Naito, Itaru Naitoh, Hiroshi Nakase, Takayoshi Nishino, Nobuyuki Ohike, Junichi Sakagami, Kyoko Shimizu, Masahiro Shiokawa, Takeshi Uehara, Tsukasa Ikeura, Shigeyuki Kawa, Kazuichi Okazaki

    Pathology international   2020.10

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    DOI: 10.1111/pin.12994

  • Decrease in fasting insulin secretory function correlates with significant liver fibrosis in Japanese non-alcoholic fatty liver disease patients.

    Norimasa Araki, Hirokazu Takahashi, Ayako Takamori, Yoichiro Kitajima, Hideyuki Hyogo, Yoshio Sumida, Saiyu Tanaka, Keizo Anzai, Shinichi Aishima, Kazuaki Chayama, Kazuma Fujimoto, Yuichiro Eguchi

    JGH open : an open access journal of gastroenterology and hepatology   2020.10

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    DOI: 10.1002/jgh3.12367

  • Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study.

    Yuji Ogawa, Takashi Kobayashi, Yasushi Honda, Takaomi Kessoku, Wataru Tomeno, Kento Imajo, Takashi Nakahara, Satoshi Oeda, Yuko Nagaoki, Yuichiro Amano, Tatsuya Ando, Megumi Hirayama, Osamu Isono, Hidenori Kamiguchi, Hiroshi Nagabukuro, Shinji Ogawa, Yoshinori Satomi, Yusuke Saigusa, Hirokazu Takahashi, Hideyuki Hyogo, Masato Yoneda, Satoru Saito, Takeharu Yamanaka, Shinichi Aishima, Yuichiro Eguchi, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakajima

    Hepatology research : the official journal of the Japan Society of Hepatology   2020.8

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    DOI: 10.1111/hepr.13528

  • Diagnostic accuracy of FibroScan-AST score to identify non-alcoholic steatohepatitis with significant activity and fibrosis in Japanese patients with non-alcoholic fatty liver disease: Comparison between M and XL probes.

    Satoshi Oeda, Hirokazu Takahashi, Kento Imajo, Yuya Seko, Takashi Kobayashi, Yuji Ogawa, Michihisa Moriguchi, Masato Yoneda, Keizo Anzai, Hiroyuki Irie, Eisaburo Sueoka, Shinichi Aishima, Masayoshi Kage, Yoshito Itoh, Yuichiro Eguchi, Atsushi Nakajima

    Hepatology research : the official journal of the Japan Society of Hepatology   2020.7

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    DOI: 10.1111/hepr.13508

  • Clinicopathological characteristics of combined hepatocellular cholangiocarcinoma from the viewpoint of patient prognosis after hepatic resection: High rate of early recurrence and its predictors.

    Yo-Ichi Yamashita, Shinichi Aishima, Yosuke Nakao, Tomoharu Yoshizumi, Hiroaki Nagano, Tamotsu Kuroki, Yuko Takami, Takao Ide, Masayuki Ohta, Mitsuhisa Takatsuki, Atsushi Nanashima, Fuminori Ishii, Kenji Kitahara, Satoshi Iino, Toru Beppu, Hideo Baba, Susumu Eguchi

    Hepatology research : the official journal of the Japan Society of Hepatology   2020.7

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    DOI: 10.1111/hepr.13507

  • Discordant pathological diagnosis of non-alcoholic fatty liver disease: A prospective multicenter study.

    Takuya Kuwashiro, Hirokazu Takahashi, Hideyuki Hyogo, Yuji Ogawa, Kento Imajo, Masato Yoneda, Takashi Nakahara, Satoshi Oeda, Kenichi Tanaka, Yuichiro Amano, Shinji Ogawa, Atsushi Kawaguchi, Shinichi Aishima, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakajima, Yuichiro Eguchi

    JGH open : an open access journal of gastroenterology and hepatology   2020.6

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    DOI: 10.1002/jgh3.12289

  • Accuracy of the Enhanced Liver Fibrosis test, and combination of the Enhanced Liver Fibrosis and non-invasive tests for the diagnosis of advanced liver fibrosis in patients with non-alcoholic fatty liver disease.

    Chika Inadomi, Hirokazu Takahashi, Yuji Ogawa, Satoshi Oeda, Kento Imajo, Yoshihito Kubotsu, Kenichi Tanaka, Takaomi Kessoku, Michiaki Okada, Hiroshi Isoda, Takumi Akiyama, Hideaki Fukushima, Masato Yoneda, Keizo Anzai, Shinichi Aishima, Atsushi Nakajima, Yuichiro Eguchi

    Hepatology research : the official journal of the Japan Society of Hepatology   2020.6

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    DOI: 10.1111/hepr.13495

  • Unclassified hepatocellular adenoma with histological brown pigment deposition and serum PIVKA-II level elevation: a case report.

    Kouki Hoshino, Norifumi Harimoto, Ryo Muranushi, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Ran Tomomasa, Sumihito Nobusawa, Shinichi Aishima, Osamu Nakashima, Ken Shirabe

    Surgical case reports   2020.5

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    DOI: 10.1186/s40792-020-00853-6

  • Accuracy of liver stiffness measurement and controlled attenuation parameter using FibroScan® M/XL probes to diagnose liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease: a multicenter prospective study.

    2020.4

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    BACKGROUND: Few studies have evaluated both liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease (NAFLD) using both FibroScan® M and XL probes. This study was performed to investigate the accuracy of both FibroScan® probes to diagnose liver fibrosis and steatosis in patients with NAFLD. METHODS: We prospectively enrolled 137 consecutive patients with clinically suspected NAFLD in our joint-research facilities. Liver biopsies, liver stiffness measurements (LSMs), and controlled attenuation parameter (CAP) measurements were performed, and 122 patients with NAFLD diagnosed pathologically by central pathologists were included in the final analysis. RESULTS: Reliable LSM results were obtained in 85.2&#37; (M) and 89.3&#37; (XL) of patients, and CAP was reliable in 90.2&#37; (M) and 90.2&#37; (XL). The median LSM was significantly lower with the XL than M probe, and CAP was significantly higher with the XL than M probe. The optimal cut-off values for diagnosing the fibrosis stage were lower for LSM with the XL than M probe (stage ≥ 2, 6.7 vs. 7.0; stage ≥ 3, 8.2 vs. 10.8; stage 4, 14.3 vs. 16.8, respectively), whereas those of CAP were higher for the XL than M probe (score of ≥ 2, 273 vs. 267; score of 3, 302 vs. 286, respectively). There were no significant differences in accuracy of the LSM and CAP between the probes. CONCLUSIONS: Liver fibrosis and steatosis could be equally evaluated with FibroScan® M and XL probes in patients with NAFLD. There was no significant difference in diagnostic accuracy between the two probes using probe-specific cut-off values.

    DOI: 10.1007/s00535-019-01635-0

  • Accumulation of Astrocytic Aquaporin 4 and Aquaporin 1 in Prion Protein Plaques.

    Shoko Sadashima, Hiroyuki Honda, Satoshi O Suzuki, Masahiro Shijo, Shinichi Aishima, Keita Kai, Junichi Kira, Toru Iwaki

    Journal of neuropathology and experimental neurology   2020.4

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    DOI: 10.1093/jnen/nlaa010

  • Fairly rare small-diameter hepatocellular carcinoma with right adrenal gland metastasis having an inferior vena cava tumor thrombus: a case report.

    Takamichi Igarashi, Norifumi Harimoto, Nozomi Matsumura, Masaya Sugiyama, Kenichiro Araki, Takehiko Yokobori, Takashi Kosone, Hitoshi Takagi, Shinichi Aishima, Hideaki Yokoo, Ken Shirabe

    Surgical case reports   2019.11

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    DOI: 10.1186/s40792-019-0705-7

  • Decreased cytokeratin 7 expression correlates with the progression of cervical squamous cell carcinoma and poor patient outcomes.

    Mariko Hashiguchi, Masanori Masuda, Keita Kai, Yoshifumi Nakao, Atsushi Kawaguchi, Masatoshi Yokoyama, Shinichi Aishima

    The journal of obstetrics and gynaecology research   2019.11

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    DOI: 10.1111/jog.14108

  • Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases.

    Hiroyuki Honda, Masaki Matsumoto, Masahiro Shijo, Hideomi Hamasaki, Shoko Sadashima, Satoshi O Suzuki, Shinichi Aishima, Keita Kai, Keiichi I Nakayama, Naokazu Sasagasako, Toru Iwaki

    Journal of neuropathology and experimental neurology   2019.10

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    DOI: 10.1093/jnen/nlz075

  • A unique autopsy case of ascending aortic dissection caused by giant cell arteritis without drug therapy.

    Yukari Takase, Yosuke Murakami, Jumpei Nishi, Osamu Tokunaga, Toshiharu Matsumoto, Shinichi Aishima

    Pathology international   2019.10

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    DOI: 10.1111/pin.12845

  • CXCL12 expression in intrahepatic cholangiocarcinoma is associated with metastasis and poor prognosis.

    Tatsunori Miyata, Yo-Ichi Yamashita, Tomoharu Yoshizumi, Masayuki Shiraishi, Masayuki Ohta, Susumu Eguchi, Shinichi Aishima, Hikaru Fujioka, Hideo Baba

    Cancer science   2019.10

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    DOI: 10.1111/cas.14151

  • IFN-γ Promotes Epithelial-Mesenchymal Transition and the Expression of PD-L1 in Pancreatic Cancer.

    2019.8

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    BACKGROUND: Tumor immune reactions not only provide host defense but also accelerate tumor immune escape and phenotype switching. Here, we examined the association of programmed cell death ligand 1 (PD-L1) expression with epithelial-mesenchymal transition (EMT)-associated markers in pancreatic ductal adenocarcinoma (PDA) within the context of the tumor microenvironment. MATERIALS AND METHODS: PDA samples from 36 patients were analyzed for PD-L1, vimentin, E-cadherin, and Snail expressions and for PDA cell and immune cell infiltration. PD-L1 expression and EMT in PDA cell lines under conditions of altering interferon gamma (IFN-γ) signals were also assessed. RESULTS: Immunohistochemistry revealed a significant correlation between vimentin and PD-L1 expression, whereas double staining showed them to be simultaneously expressed by PDA cells. Positive vimentin expression was associated with the infiltration of a lower number of CD8+ T cells and a higher number of FoxP3+ cells and poor patient prognosis (P = 0.03). PDA tumor cells promoted PD-L1 expression and EMT under the presence of IFN-γ, which was inhibited by the signal transducer and activator of transcription (STAT)1 small interfering RNA. CONCLUSIONS: Strong correlations were observed between PD-L1 expression, EMT, and the immunosuppressive tumor microenvironment. Targeting STAT1 combined with PD-1/PD-L1 immunotherapy may improve outcomes for patients with PDA.

    DOI: 10.1016/j.jss.2019.02.038

  • Transferrin receptor 1 overexpression is associated with tumour de-differentiation and acts as a potential prognostic indicator of hepatocellular carcinoma.

    Makiko Adachi, Keita Kai, Koutaro Yamaji, Takao Ide, Hirokazu Noshiro, Atsushi Kawaguchi, Shinichi Aishima

    Histopathology   2019.7

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    DOI: 10.1111/his.13847

  • Primary mucoepidermoid carcinoma of the liver with CRTC1-MAML2 fusion: a case report.

    Jiro Watanabe, Keita Kai, Ken Tanikawa, Mamoru Hiraki, Naohisa Mizukami, Shinichi Aishima, Takafumi Nakano, Hidetaka Yamamoto

    Diagnostic pathology   2019.7

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    DOI: 10.1186/s13000-019-0863-8

  • 高齢男性に急性発症した自己免疫性肝炎の1例

    鮎川 周平, 道免 和文, 小野原 伸也, 相島 慎一

    臨牀と研究 = The Japanese journal of clinical and experimental medicine   2019.2

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  • Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation.

    Keiichiro Okuyama, Yoshihiko Kitajima, Noriyuki Egawa, Hiroshi Kitagawa, Kotaro Ito, Shinichi Aishima, Kazuyoshi Yanagihara, Tomokazu Tanaka, Hirokazu Noshiro

    Scientific reports   2019.2

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    DOI: 10.1038/s41598-019-39563-x

  • External validation of ADNEX MR SCORING system: a single-centre retrospective study

    K. Sasaguri, K. Yamaguchi, T. Nakazono, M. Mizuguchi, S. Aishima, M. Yokoyama, H. Irie

    Clinical Radiology   2019.2

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    DOI: 10.1016/j.crad.2018.10.014

  • Formalin fixation on HER-2 and PD-L1 expression in gastric cancer: A pilot analysis using the same surgical specimens with different fixation times.

    Keita Kai, Yukie Yoda, Atsushi Kawaguchi, Akimichi Minesaki, Hironori Iwasaki, Shinichi Aishima, Hirokazu Noshiro

    World journal of clinical cases   2019.2

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    DOI: 10.12998/wjcc.v7.i4.419

  • Occult HBV infection status and its impact on surgical outcomes in patients with curative resection for HCV-associated hepatocellular carcinoma.

    Koutaro Yamaji, Keita Kai, Sho Komukai, Hiroki Koga, Takao Ide, Atsushi Kawaguchi, Hirokazu Noshiro, Shinichi Aishima

    Hepatobiliary surgery and nutrition   2018.12

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    DOI: 10.21037/hbsn.2018.10.01

  • Primary intrahepatic cholangiocarcinoma with sarcomatous stroma: case report and review of the literature.

    Kyohei Yugawa, Tomoharu Yoshizumi, Yohei Mano, Noboru Harada, Shinji Itoh, Toru Ikegami, Yuji Soejima, Nobuhiro Fujita, Kenichi Kohashi, Shinichi Aishima, Yoshinao Oda, Masaki Mori

    Surgical case reports   2018.11

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    DOI: 10.1186/s40792-018-0543-z

  • 肝胆道系疾患における細胞診の役割 肝胆道疾患病理に期待されること

    相島 慎一

    日本臨床細胞学会雑誌   2018.10

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  • 画像診断と病理 肝内胆管癌 肝内胆管癌の病理

    相島 慎一

    肝臓クリニカルアップデート / 肝臓クリニカルアップデート編集委員会 編   2018.10

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  • Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide.

    Toshihiko Ando, Kensuke Kojima, Haruhiko Sano, Keisuke Kidoguchi, Kana Kusaba, Mariko Yoshimura, Masako Yokoo, Yasushi Kubota, Hideaki Nakamura, Yukari Takase, Shinichi Aishima, Shinya Kimura

    Leukemia & lymphoma   2018.10

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    DOI: 10.1080/10428194.2018.1427859

  • A case report of intracholecystic papillary neoplasm of the gallbladder resembling a submucosal tumor.

    Ryo Muranushi, Hideyuki Saito, Asuka Matsumoto, Toshihide Kato, Naritaka Tanaka, Kenji Nakazato, Nobuhiro Morinaga, Yoshinori Shitara, Masatoshi Ishizaki, Takatomo Yoshida, Shinichi Aishima, Ken Shirabe

    Surgical case reports   2018.9

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    DOI: 10.1186/s40792-018-0524-2

  • Synchronous mantle cell lymphoma and lung adenocarcinoma presenting in a pleural effusion: A rare tumour combination and a potential pitfall of cytodiagnosis

    K. Kai, Y. Ryu, K. Kamochi, A. Nishioka, Y. Kubota, M. Nakamura, S. Kimura, E. Sueoka, S. Aishima

    Cytopathology   2018.8

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    DOI: 10.1111/cyt.12532

  • A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.

    Takayuki Fujii, Ryo Yamasaki, Kyoko Iinuma, Daisuke Tsuchimoto, Yoshinori Hayashi, Ban-Yu Saitoh, Takuya Matsushita, Mizuho A Kido, Shinichi Aishima, Hiroshi Nakanishi, Yusaku Nakabeppu, Jun-Ichi Kira

    Annals of neurology   2018.8

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    DOI: 10.1002/ana.25279

  • Fairly rare clear cell adenocarcinoma mimicking liver cancer: a case report.

    Norifumi Harimoto, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichirou Araki, Hayato Ikota, Masafumi Suyama, Takeshi Maki, Shinichi Aishima, Hiroyuki Kuwano, Ken Shirabe

    Surgical case reports   2018.8

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    DOI: 10.1186/s40792-018-0500-x

  • Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis.

    Yoshihiro Aiba, Kenichi Harada, Masahiro Ito, Takashi Suematsu, Shinichi Aishima, Yuki Hitomi, Nao Nishida, Minae Kawashima, Mitsuhisa Takatsuki, Susumu Eguchi, Shinji Shimoda, Hitomi Nakamura, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Kiyoshi Migita, Hiroshi Yatsuhashi, Katsushi Tokunaga, Minoru Nakamura

    Scientific reports   2018.8

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    DOI: 10.1038/s41598-018-30146-w

  • Neuroendocrine tumor of the pancreas with rhabdoid feature.

    Tetsuyuki Miyazaki, Shinichi Aishima, Minoru Fujino, Keigo Ozono, Yuichiro Kubo, Yasuhiro Ushijima, Takashi Osoegawa, Eikichi Ihara, Itou Tetsuhide, Takao Ohtsuka, Masafumi Nakamura, Yoshinao Oda

    Virchows Archiv : an international journal of pathology   2018.8

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    DOI: 10.1007/s00428-018-2398-x

  • cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.

    Elizabeth Brunt, Shinichi Aishima, Pierre-Alain Clavien, Kathryn Fowler, Zachary Goodman, Gregory Gores, Annette Gouw, Alex Kagen, David Klimstra, Mina Komuta, Fukuo Kondo, Rebecca Miksad, Masayuki Nakano, Yasuni Nakanuma, Irene Ng, Valerie Paradis, Young Nyun Park, Alberto Quaglia, Massimo Roncalli, Tania Roskams, Michiie Sakamoto, Romil Saxena, Christine Sempoux, Claude Sirlin, Ashley Stueck, Swan Thung, W M S Tsui, Xin-Wei Wang, Aileen Wee, Hirohisa Yano, Matthew Yeh, Yoh Zen, Jessica Zucman-Rossi, Neil Theise

    Hepatology (Baltimore, Md.)   2018.7

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    DOI: 10.1002/hep.29789

  • Resected primary mucinous cholangiocarcinoma of the liver.

    Kei Hagiwara, Kenichiro Araki, Takahiro Yamanaka, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Norifumi Harimoto, Hiroyuki Kuwano, Sumito Nobusawa, Shinichi Aishima, Ken Shirabe

    Surgical case reports   2018.5

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    DOI: 10.1186/s40792-018-0450-3

  • Microvascular invasion of single small hepatocellular carcinoma ≤3 cm: Predictors and optimal treatments.

    2018.5

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    BACKGROUND: Small hepatocellular carcinomas (HCC ≤3 cm) are generally considered to have low malignant potential; however, some of them display pathological microvascular invasion (MVI). METHODS: Between 1991 and 2013, 414 patients with a single HCC ≤3 cm underwent curative hepatic resection (HR). Predictors for MVI were identified. Using another cohort (149 patients during 2000-2014), our predictors for MVI in HCC ≤3 cm were validated. In 428 patients with a single HCC ≤3 cm who had predictors for MVI, survival was compared among anatomical HR (n = 149), partial HR (n = 227), and radiofrequency ablation (RFA) (n = 52). RESULTS: The positive rate of MVI reached 40.6&#37; (168/414 patients). Independent predictors for MVI were as follows: tumor diameter ≥2 cm (odds ratio 1.84, P = .0052), alpha-fetoprotein (AFP) ≥200 ng/mL (odds ratio 1.82, P = .0466), and des-gamma-carboxy prothrombin (DCP) ≥40 mAU/mL (odds ratio 1.79, P = .0126). Matching at least one predictor among these three could predict MVI in HCC ≤3 cm well (sensitivity 82.8&#37;, positive predictive value [PPV] 48.7&#37;). This criterion could also predict MVI in HCC ≤3 cm well in another cohort (sensitivity 82.8&#37;, PPV 30.3&#37;). In patients with single HCC ≤3 cm matching our criterion for predicting MVI, anatomical HR led to significantly better survival in both disease-free (hazard ratio 0.689, P = .0231) and overall (hazard ratio 0.589, P = .0316) survivals. CONCLUSION: Matching at least one factor among three (tumor diameter ≥2 cm, AFP ≥200 ng/mL, or DCP ≥40 mAU/mL) can predict MVI in HCC ≤3 cm. In such patients, anatomical HR would be recommended to improve survival.

    DOI: 10.1002/ags3.12057

  • A dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features.

    Keita Kai, Kazuma Udo, Ken Yamaguchi, Shohei Tobu, Mitsuru Noguchi, Shinichi Aishima

    Pathology international   2018.4

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    DOI: 10.1111/pin.12645

  • Correlation between smoking habit and surgical outcomes on viral-associated hepatocellular carcinomas.

    Keita Kai, Sho Komukai, Hiroki Koga, Koutaro Yamaji, Takao Ide, Atsushi Kawaguchi, Shinichi Aishima, Hirokazu Noshiro

    World journal of gastroenterology   2018.1

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    DOI: 10.3748/wjg.v24.i1.58

  • Clear Cell Carcinoma of the Uterine Cervix Presented as a Submucosal Tumor Arising in a Background of Cervical Endometriosis.

    Mariko Hashiguchi, Keita Kai, Satoshi Nishiyama, Yoshifumi Nakao, Masatoshi Yokoyama, Shinichi Aishima

    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists   2018.1

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    DOI: 10.1097/PGP.0000000000000386

  • Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma.

    Hiroki Koga, Keita Kai, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro

    World journal of hepatology   2017.12

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    DOI: 10.4254/wjh.v9.i35.1286

  • Immunoserological and histological differences between autoimmune hepatitis with acute presentation and chronic autoimmune hepatitis.

    Kazufumi Dohmen, Hirofumi Tanaka, Masatora Haruno, Shinichi Aishima

    Hepatology research : the official journal of the Japan Society of Hepatology   2017.12

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    DOI: 10.1111/hepr.12875

  • Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis.

    Kota Wakiyama, Yoshihiko Kitajima, Tomokazu Tanaka, Masao Kaneki, Kazuyoshi Yanagihara, Shinichi Aishima, Jun Nakamura, Hirokazu Noshiro

    Scientific reports   2017.10

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    DOI: 10.1038/s41598-017-12929-9

  • Colonic poorly differentiated adenocarcinoma with abundant cancer-associated fibroblasts diagnosed by trans-gastric endoscopic ultrasound-guided fine needle aspiration cytology

    M. Yamasaki, K. Kai, A. Nomura, H. Kono, H. Kawakubo, Y. Sakata, M. Mizuguchi, S. Aishima

    Cytopathology   2017.10

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    DOI: 10.1111/cyt.12443

  • 臨牀指針 小腸間膜に発生した仮性腸間膜囊腫の1例

    大岩 俊夫, 大岩 久夫, 山下 裕一, 岩崎 昭憲, 森田 勝, 西牟田 雄治, 相島 慎一, 藤原 美奈子, 城後 友望子

    臨牀と研究 = The Japanese journal of clinical and experimental medicine   2017.9

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  • Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report.

    Norihiro Ishii, Kenichiro Araki, Takahiro Yamanaka, Tadashi Handa, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Shinichi Aishima, Hiroyuki Kuwano, Ken Shirabe

    Surgical case reports   2017.9

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    DOI: 10.1186/s40792-017-0377-0

  • Autopsy case of systemic EBV-positive T-cell lymphoma of childhood with marked hepatomegaly in a middle-aged man.

    Keita Kai, Futa Koga, Norimasa Araki, Takero Shindo, Yuichiro Eguchi, Shuji Toda, Shinichi Aishima

    Pathology international   2017.8

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    DOI: 10.1111/pin.12549

  • The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer.

    Daisuke Imai, Tomoharu Yoshizumi, Shinji Okano, Hideaki Uchiyama, Toru Ikegami, Norifumi Harimoto, Shinji Itoh, Yuji Soejima, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara

    Cancer medicine   2017.7

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    DOI: 10.1002/cam4.1087

  • SLC2A1/GLUT1 expression in mural nodules of intraductal papillary mucinous neoplasm of the pancreas.

    Yasunori Oda, Shinichi Aishima, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Tetsuyuki Miyazaki, Masao Tanaka, Yoshinao Oda

    Human pathology   2017.7

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    DOI: 10.1016/j.humpath.2017.03.008

  • Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma.

    Yoshiki Asayama, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Nobuhiro Fujita, Takao Ohtsuka, Tomoharu Yoshizumi, Shinichi Aishima, Yoshinao Oda, Hiroshi Honda

    European radiology   2017.6

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    DOI: 10.1007/s00330-016-4621-y

  • Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma.

    Huanlin Wang, Kenichi Kohashi, Tomoharu Yoshizumi, Yukihiko Okumura, Yuki Tanaka, Masahiro Shimokawa, Takeshi Iwasaki, Shinichi Aishima, Yoshihiko Maehara, Yoshinao Oda

    Human pathology   2017.6

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    DOI: 10.1016/j.humpath.2017.03.007

  • Pathology of intrahepatic cholangiocarcinoma: Peripheral and perihilar type

    Shinichi Aishima

    Pathology of the Bile Duct   2017.5

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    DOI: 10.1007/978-981-10-3500-5_12

  • Hepatobiliary and Pancreatic: Hepatocellular carcinoma developed with angiomyolipoma

    T. Miyata, Y. Yamashita, T. Yamao, N. Umezaki, M. Tsukamoto, Y. Kitano, K. Yamamura, K. Arima, T. Kaida, S. Nakagawa, K. Imai, D. Hashimoto, A. Chikamoto, T. Ishiko, T. Asato, Y. Mikami, S. Aishima, H. Baba

    Journal of Gastroenterology and Hepatology (Australia)   2017.3

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    DOI: 10.1111/jgh.13655

  • Mass-forming intrahepatic cholangiocarcinoma: Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings.

    Nobuhiro Fujita, Yoshiki Asayama, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Koichiro Moirta, Ken Shirabe, Shinichi Aishima, Huanlin Wang, Yoshinao Oda, Hiroshi Honda

    European radiology   2017.2

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    DOI: 10.1007/s00330-016-4386-3

  • Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma.

    Keita Kai, Hiroki Koga, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro

    World journal of gastroenterology   2017.2

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    DOI: 10.3748/wjg.v23.i8.1397

  • Inverse correlation between CD8+ inflammatory cells and E-cadherin expression in gallbladder cancer: Tissue microarray and imaging analysis.

    Keita Kai, Masanori Masuda, Shinichi Aishima

    World journal of clinical cases   2017.1

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    DOI: 10.12998/wjcc.v5.i1.1

  • Extrahepatic cholangiocarcinoma and pancreatic duct adenocarcinoma

    Shinichi Aishima

    Biliary Diseases with Pancreatic Counterparts: A New Disease Concept   2017.1

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  • Fatty change in moderately and poorly differentiated hepatocellular carcinoma on MRI: a possible mechanism related to decreased arterial flow

    Y. Asayama, A. Nishie, K. Ishigami, Y. Ushijima, Y. Takayama, D. Okamoto, N. Fujita, Y. Kubo, S. Aishima, T. Yoshizumi, H. Honda

    Clinical Radiology   2016.12

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    DOI: 10.1016/j.crad.2016.04.020

  • Clinical Significances of Preoperative Classification of Intrahepatic Cholangiocarcinoma: Different Characteristics of Perihilar vs. Peripheral ICC.

    Yo-Ichi Yamashita, Huanlin Wang, Takeshi Kurihara, Eiji Tsujita, Akihiro Nishie, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Shinichi Aishima, Hideo Baba

    Anticancer research   2016.12

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    DOI: 10.21873/anticanres.11260

  • 特集 転移性肝腫瘍のいま-なぜ・どこが原発臓器ごとに違うのか 総論 転移性肝腫瘍の病理

    相島 慎一, 山地 康大郎

    臨床外科   2016.11

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    DOI: 10.11477/mf.1407211409

  • Malignant transformation of hepatocellular adenoma with bone marrow metaplasia arising in glycogen storage disease type I: A case report.

    Tomohiro Iguchi, Motoyuki Yamagata, Takashi Sonoda, Kimihiko Yanagita, Tetsuhiro Fukahori, Eiji Tsujita, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara

    Molecular and clinical oncology   2016.11

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  • Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1α and malignant potential in pancreatic neuroendocrine tumors.

    2016.11

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    The present study aimed to investigate the prognostic usefulness of the expression of glucose transporter type 1 (GLUT-1) and GLUT-2, hypoxia-inducible factor 1α (HIF-1α) and insulin-like growth factor II messenger RNA-binding protein 3 (IMP3) in pancreatic neuroendocrine tumors (pNETs). Immunohistochemical staining for GLUT-1, GLUT-2, HIF-1α and IMP3 was performed in 70 pNET specimens. The expression of GLUT-1 and HIF-1α was significantly higher in the World Health Organization grade 2 (G2), neuroendocrine carcinoma cases and mixed-type pNETs compared with the G1 cases. Vessel invasion, a high Ki-67 labeling index and a high mitotic count were significantly more frequent in the GLUT-1- and HIF-1α-positive cases compared with the negative cases. Lymph node metastasis was significantly higher in the GLUT-1-positive cases than in the negative cases. Insulin expression was significantly higher in the IMP3-positive cases than the negative cases. The GLUT-1 expression group experienced a significantly poor disease-free survival rate compared with the negative GLUT-1 expression group. HIF-1α expression was significantly correlated with poor disease-free survival and overall survival rates. A multivariate analysis revealed that lymph node metastasis was an independent risk factor for disease-free survival in all cases. In the G1/G2 group, tumor size and lymph node metastasis were independent risk factors for disease-free survival. Overall, the results suggested that GLUT-1 is a useful prognostic biomarker for pNETs.

    DOI: 10.3892/ol.2016.5092

  • 短期間に増大傾向を認めた肝腫瘍の1例—第93回北九州肝腫瘍研究会

    空閑 啓高, 永松 伊織, 森松 克哉, 田邊 麗子, 豊福 篤志, 轟木 秀一, 廣吉 元正, 堤 宣翁, 大江 真理, 佐藤 丈顕, 天ヶ瀬 洋正, 相島 慎一

    臨牀と研究 = The Japanese journal of clinical and experimental medicine   2016.8

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  • Effect of EGFR and p-AKT Overexpression on Chromosomal Instability in Gastric Cancer.

    Yuichi Hisamatsu, Eiji Oki, Hajime Otsu, Koji Ando, Hiroshi Saeki, Eriko Tokunaga, Shinichi Aishima, Masaru Morita, Yoshinao Oda, Yoshihiko Maehara

    Annals of surgical oncology   2016.6

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    DOI: 10.1245/s10434-016-5097-3

  • Spalt-like transcription factor 4 immunopositivity is associated with epithelial cell adhesion molecule expression in combined hepatocellular carcinoma and cholangiocarcinoma.

    Yuki Tanaka, Shinichi Aishima, Kenichi Kohashi, Yukihiko Okumura, Huanlin Wang, Tomoyuki Hida, Kazuhiro Kotoh, Ken Shirabe, Yoshihiko Maehara, Ryoichi Takayanagi, Yoshinao Oda

    Histopathology   2016.4

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    DOI: 10.1111/his.12806

  • Cytokeratin immunohistochemistry improves interobserver variability between unskilled pathologists in the evaluation of tumor budding in T1 colorectal cancer.

    Keita Kai, Shinichi Aishima, Shigehisa Aoki, Yukari Takase, Kazuyoshi Uchihashi, Masanori Masuda, Aki Nishijima-Matsunobu, Mihoko Yamamoto, Kousuke Ide, Atsushi Nakayama, Makiko Yamasaki, Shuji Toda

    Pathology international   2016.2

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    DOI: 10.1111/pin.12374

  • Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.

    2016.1

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    Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double deficiency in mouse liver (LMob1DKO) results in hyperplasia of oval cells and immature cholangiocytes accompanied by inflammatory cell infiltration and fibrosis. More than half of mutant mice die within 3 wk of birth. All survivors eventually develop liver cancers, particularly combined hepatocellular and cholangiocarcinomas (cHC-CCs) and intrahepatic cholangiocellular carcinomas (ICCs), and die by age 60 wk. Because this phenotype is the most severe among mutant mice lacking a Hippo signaling component, MOB1A/1B constitute the critical hub of Hippo signaling in mammalian liver. LMob1DKO liver cells show hyperproliferation, increased cell saturation density, hepatocyte dedifferentiation, enhanced epithelial-mesenchymal transition and cell migration, and elevated transforming growth factor beta(TGF-β)2/3 production. These changes are strongly dependent on Yes-Associated Protein-1 (Yap1) and partially dependent on PDZ-binding motif (Taz) and Tgfbr2, but independent of connective tissue growth factor (Ctgf). In human liver cancers, YAP1 activation is frequent in cHC-CCs and ICCs and correlates with SMAD family member 2 activation. Drug screening revealed that antiparasitic macrocyclic lactones inhibit YAP1 activation in vitro and in vivo. Targeting YAP1/TAZ with these drugs in combination with inhibition of the TGF-β pathway may be effective treatment for cHC-CCs and ICCs.

    DOI: 10.1073/pnas.1517188113

  • Predictors and Diagnostic Strategies for Early-Stage Pancreatic Ductal Adenocarcinoma: A Retrospective Study.

    Hideyo Kimura, Takao Ohtsuka, Taketo Matsunaga, Yusuke Watanabe, Koji Tamura, Noboru Ideno, Teppei Aso, Tetsuyuki Miyazaki, Takashi Osoegawa, Shinichi Aishima, Yoshihiro Miyasaka, Junji Ueda, Yasuhiro Ushijima, Hisato Igarashi, Tetsuhide Ito, Shunichi Takahata, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

    Pancreas   2015.10

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    DOI: 10.1097/MPA.0000000000000393

  • Predictors of Microvascular Invasion in Hepatocellular Carcinoma.

    Yo-Ichi Yamashita, Ken Shirabe, Shinichi Aishima, Yoshihiko Maehara

    Digestive diseases (Basel, Switzerland)   2015.9

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    DOI: 10.1159/000438475

  • Impact of GATA-3 and FOXA1 expression in patients with hormone receptor-positive/HER2-negative breast cancer.

    Yuichi Hisamatsu, Eriko Tokunaga, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Yuichiro Nakashima, Kenji Taketani, Shinichi Aishima, Yoshinao Oda, Masaru Morita, Yoshihiko Maehara

    Breast cancer (Tokyo, Japan)   2015.9

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    DOI: 10.1007/s12282-013-0515-x

  • Granulomatous reaction in hepatic inflammatory angiomyolipoma after chemoembolization and spontaneous rupture.

    Keita Kai, Atsushi Miyosh, Shinichi Aishima, Kota Wakiyama, Shunya Nakashita, Shinji Iwane, Shinya Azama, Hiroyuki Irie, Hirokazu Noshiro

    World journal of gastroenterology   2015.8

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    DOI: 10.3748/wjg.v21.i32.9675

  • Surgical Outcomes of Hepatic Resection for Hepatitis B Virus Surface Antigen-Negative and Hepatitis C Virus Antibody-Negative Hepatocellular Carcinoma.

    Yo-Ichi Yamashita, Daisuke Imai, Yuki Bekki, Koichi Kimura, Yoshiriro Matsumoto, Hidekazu Nakagawara, Toru Ikegami, Tomoharu Yoshizumi, Ken Shirabe, Shinichi Aishima, Yoshihiko Maehara

    Annals of surgical oncology   2015.7

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    DOI: 10.1245/s10434-014-4261-x

  • 座談会 Round Table Discussion 肝細胞癌の病理学的多様性

    坂元 亨宇, 相島 慎一, 中島 収

    The liver cancer journal = ザリバーキャンサージャーナル : 季刊学術雑誌 / 「The liver cancer journal」編集委員会 編   2015.6

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  • 桂枝加竜骨牡蛎湯,辛夷清肺湯による薬物性肝障害の1例

    道免 和文, 田中 博文, 春野 政虎, 下田 慎治, 相島 慎一

    日本消化器病学会雑誌   2015.6

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    症例は35歳時に桂枝加竜骨牡蛎湯による肝障害歴のある43歳の女性.副鼻腔炎に対し処方された辛夷清肺湯の内服後に総ビリルビン,AST,ALTの上昇がみられ,当科に紹介入院となった.辛夷清肺湯の薬物性肝障害と診断し,薬剤の中止で肝機能は正常化した.肝組織像もリンパ球・好酸球浸潤,巣状壊死の所見を認め,薬物性肝障害に合致した.桂枝加竜骨牡蛎湯,辛夷清肺湯による薬物性肝障害の報告はなく,貴重な症例と考えられた.

    DOI: 10.11405/nisshoshi.112.1054

  • New Pathologic Stratification of Microvascular Invasion in Hepatocellular Carcinoma: Predicting Prognosis After Living-donor Liver Transplantation.

    Tomohiro Iguchi, Ken Shirabe, Shinichi Aishima, Huanlin Wang, Nobuhiro Fujita, Mizuki Ninomiya, Yo-ichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Tomoharu Yoshizumi, Yoshinao Oda, Yoshihiko Maehara

    Transplantation   2015.6

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    DOI: 10.1097/TP.0000000000000489

  • Reply to Letter to the Editor by Pujals et al.

    2015.6

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    DOI: 10.1111/pin.12307

  • Recurrence 11 years after complete response to gemcitabine, 5-Fluorouracil, and Cisplatin chemotherapy followed by radiotherapy in a patient with advanced pancreatic cancer: a case report.

    Tomoyuki Uchihara, Yo-Ichi Yamashita, Wang Hualin, Kazuki Takeishi, Shinji Itoh, Norihumi Harimoto, Tomoharu Yoshizumi, Shinichi Aishima, Ken Shirabe, Hideo Baba, Yoshihiko Maehara

    Anticancer research   2015.5

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  • Long-term outcome of living-donor liver transplantation for combined hepatocellular-cholangiocarcinoma.

    Shinji Itoh, Toru Ikegami, Tomoharu Yoshizumi, Huanlin Wang, Kazuki Takeishi, Norifumi Harimoto, Yo-Ichi Yamashita, Hirofumi Kawanaka, Shinichi Aishima, Ken Shirabe, Yoshihiko Maehara

    Anticancer research   2015.4

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  • Hepatology: Rare Stevens-Johnson syndrome and vanishing bile duct syndrome induced by acetaminophen, requiring liver transplantation

    N. Harimoto, H. Wang, T. Ikegami, K. Takeishi, S. Itoh, Y. I. Yamashita, T. Yoshizumi, S. Aishima, K. Shirabe, Y. Oda, Y. Maehara

    Journal of Gastroenterology and Hepatology (Australia)   2015.4

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    DOI: 10.1111/jgh.12849

  • Correlation of HER2 expression with clinicopathological characteristics and prognosis in resectable gastric cancer.

    Hajime Otsu, Eiji Oki, Ayae Ikawa-Yoshida, Hiroyuki Kawano, Koji Ando, Satoshi Ida, Yasue Kimura, Shinichi Aishima, Hiroshi Saeki, Masaru Morita, Shunji Kohnoe, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   2015.4

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  • Evaluation of techniques to prevent colorectal anastomotic leakage.

    Tetsuo Ikeda, Ryuichi Kumashiro, Eiji Oki, Kenji Taketani, Koji Ando, Shinichi Aishima, Tomohiko Akahoshi, Masaru Morita, Yoshihiko Maehara

    The Journal of surgical research   2015.4

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    DOI: 10.1016/j.jss.2014.11.045

  • Granulomatous interstitial pneumonia induced by the intake of rice bran pickles: a rare subtype of pulmonary manifestation associated with food allergy.

    Yoshiaki Kinoshita, Atsuhiko Sakamoto, Shinichi Aishima, Kouko Hidaka

    BMJ case reports   2015.4

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    DOI: 10.1136/bcr-2014-208261

  • [α-Fetoprotein-producing tumor].

    2015.3

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  • Primary hepatic tumors with myxoid change: morphologically unique hepatic adenomas and hepatocellular carcinomas.

    Safia N Salaria, Rondell P Graham, Shinichi Aishima, Taofic Mounajjed, Matthew M Yeh, Michael S Torbenson

    The American journal of surgical pathology   2015.3

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    DOI: 10.1097/PAS.0000000000000382

  • Clinical significance of GNAS mutation in intraductal papillary mucinous neoplasm of the pancreas with concomitant pancreatic ductal adenocarcinoma.

    Noboru Ideno, Takao Ohtsuka, Taketo Matsunaga, Hideyo Kimura, Yusuke Watanabe, Koji Tamura, Teppei Aso, Shinichi Aishima, Yoshihiro Miyasaka, Kenoki Ohuchida, Junji Ueda, Shunichi Takahata, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

    Pancreas   2015.3

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    DOI: 10.1097/MPA.0000000000000258

  • Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type.

    Shinichi Aishima, Yoshinao Oda

    Journal of hepato-biliary-pancreatic sciences   2015.2

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    DOI: 10.1002/jhbp.154

  • Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition.

    Yusuke Mizuuchi, Shinichi Aishima, Kenoki Ohuchida, Koji Shindo, Minoru Fujino, Masami Hattori, Tetsuyuki Miyazaki, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

    Laboratory investigation; a journal of technical methods and pathology   2015.2

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    DOI: 10.1038/labinvest.2014.138

  • Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy.

    Yuichiroh Umemoto, Shinji Okano, Yoshihiro Matsumoto, Hidekazu Nakagawara, Rumi Matono, Shohei Yoshiya, Yo-Ichi Yamashita, Tomoharu Yoshizumi, Toru Ikegami, Yuji Soejima, Mamoru Harada, Shinichi Aishima, Yoshinao Oda, Ken Shirabe, Yoshihiko Maehara

    Journal of gastroenterology   2015.1

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    DOI: 10.1007/s00535-014-0933-3

  • Hepatocellular carcinoma: clinical significance of signal heterogeneity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging.

    Nobuhiro Fujita, Akihiro Nishie, Yuichiro Kubo, Yoshiki Asayama, Yasuhiro Ushijima, Yukihisa Takayama, Koichiro Moirta, Ken Shirabe, Shinichi Aishima, Hiroshi Honda

    European radiology   2015.1

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    DOI: 10.1007/s00330-014-3349-9

  • A novel serum marker, glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA(+)-M2BP), for assessing liver fibrosis.

    Takeo Toshima, Ken Shirabe, Toru Ikegami, Tomoharu Yoshizumi, Atsushi Kuno, Akira Togayachi, Masanori Gotoh, Hisashi Narimatsu, Masaaki Korenaga, Masashi Mizokami, Akihito Nishie, Shinichi Aishima, Yoshihiko Maehara

    Journal of gastroenterology   2015.1

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    DOI: 10.1007/s00535-014-0946-y

  • Micro RNA-373 is down-regulated in pancreatic cancer and inhibits cancer cell invasion.

    Kohei Nakata, Kenoki Ohuchida, Kazuhiro Mizumoto, Shinichi Aishima, Yoshinao Oda, Eishi Nagai, Masao Tanaka

    Annals of surgical oncology   2014.12

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    DOI: 10.1245/s10434-014-3676-8

  • Different histological sequelae of immune-mediated graft dysfunction after interferon treatment in transplanted dual grafts from living donors.

    Mizuki Ninomiya, Shinichi Aishima, Tomoharu Yoshizumi, Toru Ikegami, Huanlin Wang, Norifumi Harimoto, Shinji Ito, Hideaki Uchiyama, Yuji Soejima, Hirofumi Kawanaka, Ken Shirabe, Yoshihiko Maehara

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society   2014.12

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    DOI: 10.1002/lt.23996

  • Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: pathogenesis and histological characteristics.

    Shinichi Aishima, Yuki Tanaka, Yuichiro Kubo, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

    Pathology international   2014.11

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    DOI: 10.1111/pin.12209

  • "High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas.

    Teppei Aso, Takao Ohtsuka, Taketo Matsunaga, Hideyo Kimura, Yusuke Watanabe, Koji Tamura, Noboru Ideno, Takashi Osoegawa, Shunnichi Takahata, Koji Shindo, Yasuhiro Ushijima, Shinichi Aishima, Yoshinao Oda, Tetsuhide Ito, Kazuhiro Mizumoto, Masao Tanaka

    Pancreas   2014.11

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    DOI: 10.1097/MPA.0000000000000199

  • The apelin-APJ system induces tumor arteriogenesis in hepatocellular carcinoma.

    Jun Muto, Ken Shirabe, Tomoharu Yoshizumi, Toru Ikegami, Shinichi Aishima, Kousei Ishigami, Yoshikazu Yonemitsu, Tetsuo Ikeda, Yuji Soejima, Yoshihiko Maehara

    Anticancer research   2014.10

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  • Gallbladder cancer: Clinical and pathological approach.

    Keita Kai, Shinichi Aishima, Kohji Miyazaki

    World journal of clinical cases   2014.10

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    DOI: 10.12998/wjcc.v2.i10.515

  • Pathological manifestation of difference in washout pattern of adrenal hyperplasia on dynamic CT.

    Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, Yasuhiro Ushijima, Yukihisa Takayama, Akira Yokomizo, Katsunori Tatsugami, Junichi Inokuchi, Nobuhiro Fujita, Yuichiro Kubo, Shinichi Aishima, Masakazu Hirakawa, Hiroshi Honda

    Journal of medical imaging and radiation oncology   2014.10

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    DOI: 10.1111/1754-9485.12211

  • Podoplanin expression in the cyst wall correlates with the progression of intraductal papillary mucinous neoplasm.

    Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Takao Ohtsuka, Shoji Tokunaga, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

    Virchows Archiv : an international journal of pathology   2014.9

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    DOI: 10.1007/s00428-014-1610-x

  • Correlation between biological marker expression and fluorine-18 fluorodeoxyglucose uptake in hepatocellular carcinoma.

    Yohei Mano, Shinichi Aishima, Yuichiro Kubo, Yuki Tanaka, Takashi Motomura, Takeo Toshima, Ken Shirabe, Shingo Baba, Yoshihiko Maehara, Yoshinao Oda

    American journal of clinical pathology   2014.9

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    DOI: 10.1309/AJCPG8AFJ5NRKLLM

  • Pancreatic intraepithelial neoplasia in the background of invasive ductal carcinoma of the pancreas as a prognostic factor.

    Yasunori Oda, Shinichi Aishima, Katsuya Morimatsu, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Tetsuyuki Miyazaki, Masao Tanaka, Yoshinao Oda

    Histopathology   2014.9

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    DOI: 10.1111/his.12397

  • Significance of accurate human epidermal growth factor receptor-2 (HER2) evaluation as a new biomarker in gastric cancer.

    Yasue Kimura, Eiji Oki, Ayae Yoshida, Shinichi Aishima, Yoko Zaitsu, Hajime Ohtsu, Koji Ando, Satoshi Ida, Hiroshi Saeki, Masaru Morita, Tetsuya Kusumoto, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   2014.8

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  • Different expression of glucose transporters in the progression of intrahepatic cholangiocarcinoma.

    Yuichiro Kubo, Shinichi Aishima, Yuki Tanaka, Koji Shindo, Yusuke Mizuuchi, Koichiro Abe, Ken Shirabe, Yoshihiko Maehara, Hiroshi Honda, Yoshinao Oda

    Human pathology   2014.8

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    DOI: 10.1016/j.humpath.2014.03.008

  • Phase II study of docetaxel and S-1 (DS) as neoadjuvant chemotherapy for clinical stage III resectable gastric cancer.

    Eiji Oki, Yasunori Emi, Tetsuya Kusumoto, Yoshihisa Sakaguchi, Manabu Yamamoto, Noriaki Sadanaga, Mototsugu Shimokawa, Takeharu Yamanaka, Hiroshi Saeki, Masaru Morita, Ikuo Takahashi, Naoki Hirabayashi, Kenji Sakai, Hiroyuki Orita, Shinichi Aishima, Yoshihiro Kakeji, Kazuya Yamaguchi, Kazuhiro Yoshida, Hideo Baba, Yoshihiko Maehara

    Annals of surgical oncology   2014.7

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    DOI: 10.1245/s10434-014-3594-9

  • Histological features of precancerous and early cancerous lesions of biliary tract carcinoma.

    Shinichi Aishima, Yuichiro Kubo, Yuki Tanaka, Yoshinao Oda

    Journal of hepato-biliary-pancreatic sciences   2014.7

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    DOI: 10.1002/jhbp.71

  • New scoring system for prediction of microvascular invasion in patients with hepatocellular carcinoma.

    Ken Shirabe, Takeo Toshima, Koichi Kimura, Yoichi Yamashita, Tetsuo Ikeda, Toru Ikegami, Tomoharu Yoshizumi, Koichiro Abe, Shinichi Aishima, Yoshihiko Maehara

    Liver international : official journal of the International Association for the Study of the Liver   2014.7

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    DOI: 10.1111/liv.12459

  • Peritoneal myofibroblasts at metastatic foci promote dissemination of pancreatic cancer.

    Shin Akagawa, Kenoki Ohuchida, Nobuhiro Torata, Masami Hattori, Daiki Eguchi, Kenji Fujiwara, Shingo Kozono, Lin Cui, Naoki Ikenaga, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto, Yoshinao Oda, Masao Tanaka

    International journal of oncology   2014.7

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    DOI: 10.3892/ijo.2014.2391

  • Role of tumor-associated macrophages in the angiogenesis of well-differentiated hepatocellular carcinoma: pathological-radiological correlation.

    Nobuhiro Fujita, Akihiro Nishie, Shinichi Aishima, Yuichiro Kubo, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Yasuhiro Ushijima, Yukihisa Takayama, Ken Shirabe, Yoshinao Oda, Hiroshi Honda

    Oncology reports   2014.6

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    DOI: 10.3892/or.2014.3138

  • Analysis of risk factors for recurrence after curative resection of well-differentiated pancreatic neuroendocrine tumors based on the new grading classification.

    Kosuke Tsutsumi, Takao Ohtsuka, Minoru Fujino, Hiroshi Nakashima, Shinichi Aishima, Junji Ueda, Shunichi Takahata, Masafumi Nakamura, Yoshinao Oda, Masao Tanaka

    Journal of hepato-biliary-pancreatic sciences   2014.6

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    DOI: 10.1002/jhbp.47

  • Chronic immune-mediated reaction syndrome as the cause of late graft mortality in living-donor liver transplantation for primary biliary cirrhosis

    N. Harimoto, T. Ikegami, H. Nakagawara, Y. I. Yamashita, T. Yoshizumi, H. Uchiyama, Y. Soejima, T. Ikeda, K. Shirabe, S. Aishima, Y. Oda, Y. Maehara

    Transplantation Proceedings   2014.6

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    DOI: 10.1016/j.transproceed.2014.02.021

  • Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma.

    Mikako Osada, Shinichi Aishima, Minako Hirahashi, Nobuyoshi Takizawa, Shunsuke Takahashi, Kazuhiko Nakamura, Masao Tanaka, Yoshihiko Maehara, Ryoichi Takayanagi, Yoshinao Oda

    Human pathology   2014.6

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    DOI: 10.1016/j.humpath.2014.02.003

  • Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer.

    Eriko Tokunaga, Yuichiro Nakashima, Nami Yamashita, Yuichi Hisamatsu, Satoko Okada, Sayuri Akiyoshi, Shinichi Aishima, Hiroyuki Kitao, Masaru Morita, Yoshihiko Maehara

    Breast cancer (Tokyo, Japan)   2014.5

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    DOI: 10.1007/s12282-012-0398-2

  • Strategies to treat interferon-induced graft dysfunction after living donor liver transplantation for hepatitis C.

    Toru Ikegami, Huanlin Wang, Tomoharu Yoshizumi, Takeo Toshima, Shinichi Aishima, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Shinji Shimoda, Ken Shirabe, Yoshihiko Maehara

    Hepatology international   2014.4

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    DOI: 10.1007/s12072-013-9496-2

  • A case of invasive micropapillary carcinoma of the breast involving extensive lymph node metastasis.

    Kenji Taketani, Eriko Tokunaga, Nami Yamashita, Kimihiro Tanaka, Yoko Zaitsu, Sayuri Akiyoshi, Satoko Okada, Shinichi Aishima, Masaru Morita, Yoshihiko Maehara

    World journal of surgical oncology   2014.4

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    DOI: 10.1186/1477-7819-12-84

  • Elevated expression level of microRNA-196a is predictive of intestinal-type intraductal papillary mucinous neoplasm of the pancreas.

    Teppei Aso, Takao Ohtsuka, Koji Tamura, Noboru Ideno, Hiroshi Kono, Yosuke Nagayoshi, Kennoki Ohuchida, Junji Ueda, Shunnichi Takahata, Koji Shindo, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

    Pancreas   2014.4

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    DOI: 10.1097/MPA.0000000000000042

  • Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.

    Minako Hirahashi, Yutaka Koga, Reiko Kumagai, Shinichi Aishima, Kenichi Taguchi, Yoshinao Oda

    Pathology international   2014.4

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    DOI: 10.1111/pin.12152

  • PS-155-1 当院における胆管内乳頭状腫瘍(IPNB)切除例の検討(PS-155 肝 胆道腫瘍・その他,ポスターセッション,第114回日本外科学会定期学術集会)

    梶山 潔, 皆川 亮介, 丸山 晴司, 井口 詔一, 廣瀬 皓介, 赤峰 翔, 影山 優美子, 平山 佳愛, 高橋 良影, 武谷 憲二, 中ノ子 智徳, 吉田 倫太郎, 古賀 聡, 甲斐 正徳, 増本 陽秀, 福谷 龍郎, 大屋 正文, 相島 慎一

    日本外科学会雑誌   2014.3

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  • OP-005-2 肝癌に対する生体肝移植後の肝癌再発の新たな予後因子 : 侵襲の程度に基づく組織学的高度脈管侵襲分類の有用性(OP-005 肝 移植-2,一般演題,第114回日本外科学会定期学術集会)

    井口 友宏, 調 憲, 池上 徹, 吉住 朋晴, 別城 悠樹, 王 歓林, 今井 大祐, 松本 佳大, 木村 光一, 中川原 英和, 吉屋 匠平, 二宮 瑞樹, 山下 洋市, 内山 秀昭, 副島 雄二, 川中 博文, 池田 哲夫, 相島 慎一, 小田 義直, 前原 喜彦

    日本外科学会雑誌   2014.3

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  • PLS-10-3 主膵管型IPMNのmonoclonalityとGNAS遺伝子変異の意義(PLS-10 プレナリーセッション(10)「膵臓」,第114回日本外科学会定期学術集会)

    田村 公二, 大塚 隆生, 松永 壮人, 木村 英世, 渡邉 雄介, 井手野 昇, 安蘓 鉄平, 宮崎 哲之, 相島 慎一, 大内田 研宙, 上田 純二, 高畑 俊一, 小田 義直, 水元 一博, 田中 雅夫

    日本外科学会雑誌   2014.3

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  • Key endoscopic ultrasound features of pancreatic ductal adenocarcinoma smaller than 20 mm.

    Akira Aso, Eikichi Ihara, Takashi Osoegawa, Kazuhiko Nakamura, Soichi Itaba, Hisato Igarashi, Tetsuhide Ito, Shinichi Aishima, Yoshinao Oda, Masao Tanaka, Ryoichi Takayanagi

    Scandinavian journal of gastroenterology   2014.3

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    DOI: 10.3109/00365521.2013.878745

  • Treatment strategy for main duct intraductal papillary mucinous neoplasms of the pancreas based on the assessment of recurrence in the remnant pancreas after resection: a retrospective review.

    Koji Tamura, Takao Ohtsuka, Noboru Ideno, Teppei Aso, Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Shunichi Takahata, Yasuhiro Ushijima, Tetsuhide Ito, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

    Annals of surgery   2014.2

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    DOI: 10.1097/SLA.0b013e3182a690ff

  • Follicular pancreatitis, report of a case clinically mimicking pancreatic cancer and literature review.

    Yusuke Mizuuchi, Shinichi Aishima, Masami Hattori, Yasuhiro Ushijima, Akira Aso, Shunichi Takahata, Takao Ohtsuka, Junji Ueda, Masao Tanaka, Yoshinao Oda

    Pathology, research and practice   2014.2

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    DOI: 10.1016/j.prp.2013.09.005

  • 特集 見直される膵癌診療の新展開 診断における新展開 膵液細胞診および膵液遺伝子検査による膵癌診断

    安蘓 鉄平, 大塚 隆生, 木村 英世, 松永 壮人, 渡邉 雄介, 田村 公二, 井手野 昇, 大内田 研宙, 上田 純二, 高畑 俊一, 相島 慎一, 五十嵐 久人, 伊藤 鉄英, 小田 義直, 水元 一博, 田中 雅夫

    臨床外科   2014.1

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    DOI: 10.11477/mf.1407104900

  • Tissue tablet method: an efficient tissue banking procedure applicable to both molecular analysis and frozen tissue microarray.

    Nobuhiro Torata, Kenoki Ohuchida, Shin Akagawa, Lin Cui, Shingo Kozono, Kazuhiro Mizumoto, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

    Human pathology   2014.1

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    DOI: 10.1016/j.humpath.2013.08.013

  • Expression of glucagon-like Peptide 1 receptor and its effects on biologic behavior in pancreatic neuroendocrine tumors.

    Ana Ines Cases, Takao Ohtsuka, Minoru Fujino, Noboru Ideno, Shingo Kozono, Ming Zhao, Kenoki Ohuchida, Shinichi Aishima, Masatoshi Nomura, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

    Pancreas   2014.1

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    DOI: 10.1097/MPA.0b013e3182a71537

  • Intraoperative irrigation cytology of the remnant pancreas to detect remnant distinct pancreatic ductal adenocarcinoma in patients with intraductal papillary mucinous neoplasm undergoing partial pancreatectomy.

    Yasuhisa Mori, Takao Ohtsuka, Koji Tamura, Noboru Ideno, Teppei Aso, Hiroshi Kono, Yosuke Nagayoshi, Junji Ueda, Shunichi Takahata, Shinichi Aishima, Fumihiko Ookubo, Yoshinao Oda, Masao Tanaka

    Surgery   2014.1

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    DOI: 10.1016/j.surg.2013.06.059

  • Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia.

    Yasunori Sato, Motoko Sasaki, Kenichi Harada, Shinichi Aishima, Toshio Fukusato, Hidenori Ojima, Yae Kanai, Masayoshi Kage, Yasuni Nakanuma, Hirohito Tsubouchi

    Journal of gastroenterology   2014.1

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    DOI: 10.1007/s00535-013-0810-5

  • Spontaneous massive necrosis of hepatocellular carcinoma with narrowing and occlusion of the arteries and portal veins.

    Takahiro Tomino, Yo-Ichi Yamashita, Tomohiro Iguchi, Shinji Itoh, Mizuki Ninomiya, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Hirofumi Kawanaka, Tetsuo Ikeda, Shinichi Aishima, Ken Shirabe, Yoshihiko Maehara

    Case reports in gastroenterology   2014.1

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    DOI: 10.1159/000362440

  • mFOLFOX6療法後に発症した門脈圧亢進症の1例

    緒方 大聡, 具嶋 敏文, 丸岡 新子, 高崎 智子, 田中 吏佐, 松浦 隆志, 相島 慎一, 高橋 和弘

    日本消化器病学会雑誌   2013.12

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    症例は46歳男性.S状結腸癌肝転移の診断でS状結腸切除術,肝部分切除術,胆嚢切除術を施行された.術後化学療法としてmFOLFOX6療法を施行された頃から血小板減少と脾腫が出現し,3年後にF3の食道胃静脈瘤を認めた.肝生検組織では,大腸癌手術時の摘出肝と比して類洞の拡張に加え門脈が狭小化して不明瞭となっていた.Oxaliplatinは非肝硬変性の門脈圧亢進症をきたすことがあり,留意すべきである.

    DOI: 10.11405/nisshoshi.110.2119, 10.2957/kanzo.61.358_references_DOI_UKRW5UlBD1NDFXslFg78J5YToE0, 10.5833/jjgs.2017.0194_references_DOI_UKRW5UlBD1NDFXslFg78J5YToE0

  • Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas.

    Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Kenji Fujiwara, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

    Molecular cancer   2013.12

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    DOI: 10.1186/1476-4598-12-168

  • Differential impact of the expression of the androgen receptor by age in estrogen receptor-positive breast cancer.

    Eriko Tokunaga, Yuichi Hisamatsu, Kenji Taketani, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Kimihiro Tanaka, Hiroshi Saeki, Eiji Oki, Shinichi Aishima, Yoshinao Oda, Masaru Morita, Yoshihiko Maehara

    Cancer medicine   2013.12

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    DOI: 10.1002/cam4.138

  • Migratory activity of CD105+ pancreatic cancer cells is strongly enhanced by pancreatic stellate cells.

    Kenji Fujiwara, Kenoki Ohuchida, Takao Ohtsuka, Kazuhiro Mizumoto, Koji Shindo, Naoki Ikenaga, Lin Cui, Shunichi Takahata, Shinichi Aishima, Masao Tanaka

    Pancreas   2013.11

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    DOI: 10.1097/MPA.0b013e318293e7bd

  • Decreased roundabout 1 expression promotes development of intrahepatic cholangiocarcinoma.

    Yohei Mano, Shinichi Aishima, Takasuke Fukuhara, Yuki Tanaka, Yuichiro Kubo, Takashi Motomura, Takeo Toshima, Tomohiro Iguchi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

    Human pathology   2013.11

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    DOI: 10.1016/j.humpath.2013.03.022

  • 特集 術前画像診断のポイントと術中解剖認識 IV.肝・胆・膵 IPMN

    渡邉 雄介, 大塚 隆生, 田村 公二, 木村 英世, 松永 壮人, 井手野 昇, 安蘇 鉄平, 上田 純二, 高畑 俊一, 牛島 泰宏, 伊藤 鉄英, 水内 祐介, 相島 慎一, 小田 義直, 水元 一博, 田中 雅夫

    臨床外科   2013.10

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    DOI: 10.11477/mf.1407104812

  • A case of fatal intrahepatic cholestasis with primary AL amyloidosis: is early diagnosis possible?

    Shinichiro Takao, Kosuke Tanaka, Masayuki Miyazaki, Masatake Tanaka, Tomoko Ohashi, Masaki Kato, Kazuhiro Kotoh, Shinichi Aishima, Ryoichi Takayanagi

    Clinical journal of gastroenterology   2013.10

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    DOI: 10.1007/s12328-013-0406-x

  • Insulin-like growth factor II messenger RNA-binding protein-3 is a valuable diagnostic and prognostic marker of intraductal papillary mucinous neoplasm.

    Katsuya Morimatsu, Shinichi Aishima, Hidetaka Yamamoto, Akifumi Hayashi, Kohei Nakata, Yasunori Oda, Koji Shindo, Minoru Fujino, Masao Tanaka, Yoshinao Oda

    Human pathology   2013.9

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    DOI: 10.1016/j.humpath.2012.12.020

  • S-1/Docetaxel併用療法にて同時性肝転移が病理学的完全奏効となった胃癌の1例

    北原大和, 沖英次, 佐伯浩司, 安藤幸滋, 調憲, 鴻江俊治, 相島慎一, 掛地吉弘, 前原喜彦

    癌と化学療法   2013.8

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  • Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis.

    Yohei Mano, Ken Shirabe, Yo-Ichi Yamashita, Norifumi Harimoto, Eiji Tsujita, Kazuki Takeishi, Shinichi Aishima, Toru Ikegami, Tomoharu Yoshizumi, Takeharu Yamanaka, Yoshihiko Maehara

    Annals of surgery   2013.8

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    DOI: 10.1097/SLA.0b013e318297ad6b

  • Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas.

    Yasunori Oda, Shinichi Aishima, Katsuya Morimatsu, Akifumi Hayashi, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Masao Tanaka, Yoshinao Oda

    Human pathology   2013.8

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    DOI: 10.1016/j.humpath.2012.12.001

  • Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype.

    Noboru Ideno, Takao Ohtsuka, Hiroshi Kono, Kenji Fujiwara, Yasunori Oda, Shinichi Aishima, Tetsuhide Ito, Kousei Ishigami, Shoji Tokunaga, Kenoki Ohuchida, Shunichi Takahata, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

    Annals of surgery   2013.7

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    DOI: 10.1097/SLA.0b013e31828cd008

  • Distinctive histopathologic findings of pancreatic hamartomas suggesting their "hamartomatous" nature: a study of 9 cases.

    Hiroshi Yamaguchi, Shinichi Aishima, Yoshinao Oda, Hiroki Mizukami, Takuma Tajiri, Sohsuke Yamada, Takashi Tasaki, Keisuke Yamakita, Koji Imai, Fumi Kawakami, Shigeo Hara, Keiji Hanada, Tomohiro Iiboshi, Toshikatsu Fukuda, Hiroshi Imai, Hiroyuki Inoue, Tatsuya Nagakawa, Shunji Muraoka, Toru Furukawa, Michio Shimizu

    The American journal of surgical pathology   2013.7

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    DOI: 10.1097/PAS.0b013e318283ce4c

  • High expression of microRNA-155 is associated with the aggressive malignant behavior of gallbladder carcinoma.

    Hiroshi Kono, Masafumi Nakamura, Takao Ohtsuka, Yosuke Nagayoshi, Yasuhisa Mori, Shunichi Takahata, Shinichi Aishima, Masao Tanaka

    Oncology reports   2013.7

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    DOI: 10.3892/or.2013.2443

  • Early extensive viremia, but not rs8099917 genotype, is the only predictor for cholestatic hepatitis C after living-donor liver transplantation.

    Toru Ikegami, Ken Shirabe, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Masaki Kato, Shinji Shimoda, Shinichi Aishima, Yuji Soejima, Tomoharu Yoshizumi, Yoshihiko Maehara

    Hepatology research : the official journal of the Japan Society of Hepatology   2013.6

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    DOI: 10.1111/hepr.12003

  • Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma.

    Shinichi Aishima, Yohei Mano, Yuki Tanaka, Yuichiro Kubo, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

    Human pathology   2013.6

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    DOI: 10.1016/j.humpath.2012.09.004

  • Vimentin as a poor prognostic factor for triple-negative breast cancer.

    Nami Yamashita, Eriko Tokunaga, Hiroyuki Kitao, Yuichi Hisamatsu, Kenji Taketani, Sayuri Akiyoshi, Satoko Okada, Shinichi Aishima, Masaru Morita, Yoshihiko Maehara

    Journal of cancer research and clinical oncology   2013.5

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    DOI: 10.1007/s00432-013-1376-6

  • Clinical usefulness of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography for patients with primary liver cancer with special reference to rare histological types, hepatocellular carcinoma with sarcomatous change and combined hepatocellular and cholangiocarcinoma.

    Hideki Ijichi, Ken Shirabe, Akinobu Taketomi, Tomoharu Yoshizumi, Toru Ikegami, Youhei Mano, Shinichi Aishima, Koichiro Abe, Hiroshi Honda, Yoshihiko Maehara

    Hepatology research : the official journal of the Japan Society of Hepatology   2013.5

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    DOI: 10.1111/j.1872-034X.2012.01107.x

  • Kindlin-1 expression is involved in migration and invasion of pancreatic cancer.

    Prawej Mahawithitwong, Kenoki Ohuchida, Naoki Ikenaga, Hayato Fujita, Ming Zhao, Shingo Kozono, Koji Shindo, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto, Masao Tanaka

    International journal of oncology   2013.4

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    DOI: 10.3892/ijo.2013.1838

  • Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case.

    Mikihiro Kohno, Ken Shirabe, Yohei Mano, Jun Muto, Takashi Motomura, Kazuki Takeishi, Takeo Toshima, Masanori Yoshimatsu, Hideki Ijichi, Noboru Harada, Shinichi Aishima, Hideaki Uchiyama, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara

    Surgery today   2013.4

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    DOI: 10.1007/s00595-012-0202-0

  • YT-7-6(YRA) GNAS変異を有しない膵管内乳頭粘液性腫瘍は通常型膵癌を合併する頻度が高い(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会)

    井手 野昇, 大塚 隆生, 小田 康徳, 田村 公二, 安蕪 鉄平, 河野 博, 永吉 洋介, 相島 慎一, 大内田 研宙, 上田 純二, 高畑 俊一, 水元 一博, 田中 雅夫

    日本外科学会雑誌   2013.3

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  • PD-2-1 根治切除可能な進行胃癌に対する術前Docetaxel/S-1併用補助化学療法の多施設共同臨床第II相試験(PD パネルディスカッション,第113回日本外科学会定期学術集会)

    楠本 哲也, 沖 英次, 江見 泰徳, 掛地 吉弘, 坂口 善久, 吉田 和弘, 馬場 秀夫, 相島 慎一, 徳永 章二, 前原 喜彦

    日本外科学会雑誌   2013.3

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  • PS-113-6 CD166陰性膵癌細胞は強い浸潤能・遊走能を有する(PS ポスターセッション,第113回日本外科学会定期学術集会)

    藤原 謙次, 大内田 研宙, 進藤 幸治, 赤川 進, 江口 大樹, 小薗 真吾, 崔 林, 大塚 隆生, 高畑 俊一, 相島 慎一, 水元 一博, 田中 雅夫

    日本外科学会雑誌   2013.3

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  • PS-225-1 主膵管型IPMNの治療戦略 : 残膵再発例から見た至適術式の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    田村 公二, 大塚 隆生, 進藤 幸治, 井手野 昇, 安蕪 鉄平, 河野 博, 永吉 洋介, 大内田 研宙, 相島 慎一, 上田 純二, 高畑 俊一, 水元 一博, 田中 雅夫

    日本外科学会雑誌   2013.3

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  • PS-226-6 腸型膵管内乳頭粘液性腫瘍(IPMN)におけるmicroRNA-196aの高発現(PS ポスターセッション,第113回日本外科学会定期学術集会)

    安蘓 鉄平, 大塚 隆生, 田村 公二, 井手野 昇, 河野 博, 永吉 洋介, 進藤 幸治, 大内田 研宙, 相島 慎一, 上田 純二, 高畑 俊一, 水元 一博, 田中 雅夫

    日本外科学会雑誌   2013.3

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  • PS-341-3 生体肝移植術後における胆汁うっ滞性C型肝炎発症の規定因子の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    松本 佳大, 調 憲, 副島 雄二, 吉住 朋晴, 池上 徹, 山下 洋市, 相島 慎一, 播本 憲史, 戸島 剛男, 吉屋 匠平, 中川原 英和, 川崎 淳司, 木村 光一, 前原 喜彦

    日本外科学会雑誌   2013.3

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  • PS-375-4 高品質かつ簡便な凍結組織アレイ作製法 : 手術切除組織を効率良く保存する保存組織タブレット法を活用して(PS ポスターセッション,第113回日本外科学会定期学術集会)

    寅田 信博, 赤川 進, 崔 林, 大内田 研宙, 小園 真吾, 水元 一博, 相島 慎一, 小田 義直, 田中 雅夫

    日本外科学会雑誌   2013.3

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  • RSF-14-1 胃カルチノイド同時性肝転移の一切除例に関する検討(RSF 研修医の発表セッション,第113回日本外科学会定期学術集会)

    佐々木 駿, 井田 智, 安藤 幸滋, 木村 和恵, 佐伯 浩司, 沖 英次, 森田 勝, 楠本 哲也, 池田 哲夫, 相島 慎一, 前原 喜彦

    日本外科学会雑誌   2013.3

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  • Role of endoscopic retrograde pancreatography for early detection of pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm of the pancreas.

    Takao Ohtsuka, Noboru Ideno, Teppei Aso, Yosuke Nagayoshi, Hiroshi Kono, Yasuhisa Mori, Shunichi Takahata, Yasunori Oda, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

    Journal of hepato-biliary-pancreatic sciences   2013.3

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    DOI: 10.1007/s00534-012-0541-7

  • Ezrin expression and its phosphorylation in gastric carcinoma with lymphoid stroma and Epstein-Barr virus infection.

    Taro Tobo, Minako Hirahashi, Takashi Yao, Shinichi Aishima, Yoshinao Oda

    Molecular and clinical oncology   2013.3

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  • Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC.

    Masatake Tanaka, Yuko Masaki, Kosuke Tanaka, Masayuki Miyazaki, Masaki Kato, Rie Sugimoto, Kazuhiko Nakamura, Shinichi Aishima, Ken Shirabe, Makoto Nakamuta, Munechika Enjoji, Kazuhiro Kotoh, Ryoichi Takayanagi

    Molecular medicine reports   2013.2

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    DOI: 10.3892/mmr.2012.1201

  • A morphological study of the removed livers from patients receiving living donor liver transplantation for adult biliary atresia.

    Toshiharu Matsuura, Kenichi Kohashi, Yusuke Yanagi, Isamu Saeki, Makoto Hayashida, Shinichi Aishima, Yoshinao Oda, Tomoaki Taguchi

    Pediatric surgery international   2012.12

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    DOI: 10.1007/s00383-012-3183-6

  • Management strategy for multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas.

    Yasuhisa Mori, Takao Ohtsuka, Hiroshi Kono, Noboru Ideno, Teppei Aso, Yosuke Nagayoshi, Shunichi Takahata, Masafumi Nakamura, Kousei Ishigami, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

    Pancreas   2012.10

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    DOI: 10.1097/MPA.0b013e31824b22c6

  • The risk of lymph node metastasis in mucosal gastric carcinoma: especially for a mixture of differentiated and undifferentiated adenocarcinoma.

    Kohei Nakata, Eishi Nagai, Yoshihiro Miyasaka, Kenoki Ohuchida, Takao Ohtsuka, Hiroki Toma, Minako Hirahashi, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

    Hepato-gastroenterology   2012.9

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    DOI: 10.5754/hge10130

  • Diagnostic significance of a dilated orifice of the duodenal papilla in intraductal papillary mucinous neoplasm of the pancreas.

    Teppei Aso, Takao Ohtsuka, Noboru Ideno, Hiroshi Kono, Yosuke Nagayoshi, Yasuhisa Mori, Kennoki Ohuchida, Junji Ueda, Shunnichi Takahata, Katsuya Morimatsu, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Kazuhiro Mizumoto, Masao Tanaka

    Gastrointestinal endoscopy   2012.8

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    DOI: 10.1016/j.gie.2012.03.682

  • Primary graft dysfunction after living donor liver transplantation is characterized by delayed functional hyperbilirubinemia

    Toru Ikegami, K. Shirabe, T. Yoshizumi, S. Aishima, Y. A. Taketomi, Y. Soejima, H. Uchiyama, H. Kayashima, T. Toshima, Y. Maehara

    American Journal of Transplantation   2012.7

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    DOI: 10.1111/j.1600-6143.2012.04052.x

  • Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas.

    Takao Ohtsuka, Hiroshi Kono, Reiko Tanabe, Yosuke Nagayoshi, Yasuhisa Mori, Yoshihiko Sadakari, Shunichi Takahata, Yasunori Oda, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

    American journal of surgery   2012.7

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    DOI: 10.1016/j.amjsurg.2011.04.007

  • Predictors for microinvasion of small hepatocellular carcinoma ≤ 2 cm.

    2012.6

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    BACKGROUND: Hepatocellular carcinoma (HCC) ≤ 2 cm in diameter is considered to have a low potential for malignancy. METHODS: A retrospective review was undertaken of 149 patients with primary solitary HCC ≤ 2 cm who underwent initial hepatic resection between 1994 and 2010. The independent predictors of the microinvasion (MI) such as portal venous, hepatic vein, or bile duct infiltration and/or intrahepatic metastasis were identified by multivariate analysis. Prognosis of patients with HCC ≤ 2 cm accompanied by MI was compared to that of patients with HCC ≤ 2 cm without MI. RESULTS: Forty-three patients with HCC ≤ 2 cm had MI in patients (28.9&#37;). Three independent predictors of the MI were revealed: invasive gross type (simple nodular type with extranodular growth or confluent multinodular type), des-γ-carboxy prothrombin (DCP) >100 mAU/ml, and poorly differentiated. Disease-free survival rates of patients with HCC ≤ 2 cm with MI (3 year 44&#37;) were significantly worse than those for HCC ≤ 2 cm without MI (3 year 72&#37;). This disadvantage of disease-free survival rate of patients with HCC ≤ 2 cm with MI could be dissolved by hepatic resection with a wide tumor margin of ≥ 5 mm (P = 0.04). CONCLUSIONS: Even in cases of HCC ≤ 2 cm, patients who are suspected of having invasive gross type tumors in preoperative imaging diagnosis or who have a high DCP level (>100 mAU/ml) are at risk for MI. Therefore, in such patients, hepatic resection with a wide tumor margin should be recommended.

    DOI: 10.1245/s10434-011-2195-0

  • Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production.

    Kosuke Tsutsumi, Takao Ohtsuka, Yasuhisa Mori, Minoru Fujino, Takaharu Yasui, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Tetsuhide Ito, Masao Tanaka

    Journal of gastroenterology   2012.6

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    DOI: 10.1007/s00535-012-0540-0

  • Enhancement pattern analysis of hypervascular hepatocellular carcinoma on dynamic MR imaging with histopathological correlation: validity of portal phase imaging for predicting tumor grade.

    Daisuke Okamoto, Kengo Yoshimitsu, Akihiro Nishie, Tsuyoshi Tajima, Yoshiki Asayama, Kousei Ishigami, Masakazu Hirakawa, Yasuhiro Ushijima, Daisuke Kakihara, Tomohiro Nakayama, Yunosuke Nishihara, Shinichi Aishima, Akinobu Taketomi, Junji Kishimoto, Hiroshi Honda

    European journal of radiology   2012.6

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    DOI: 10.1016/j.ejrad.2011.02.056

  • Impact of FOXA1 expression on the prognosis of patients with hormone receptor-positive breast cancer.

    Yuichi Hisamatsu, Eriko Tokunaga, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Yuichiro Nakashima, Shinichi Aishima, Masaru Morita, Yoshihiro Kakeji, Yoshihiko Maehara

    Annals of surgical oncology   2012.4

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    DOI: 10.1245/s10434-011-2094-4

  • SF-074-5 膵癌におけるCD271陽性膵星細胞の意義(SF-074 サージカルフォーラム(74)膵 基礎-3(間質相互作用),第112回日本外科学会定期学術集会)

    藤原 謙次, 大内田 研宙, 進藤 幸治, 赤川 進, 江口 大樹, 小薗 真吾, 池永 直樹, 崔 林, 相島 慎一, 大塚 隆生, 高畑 俊一, 水元 一博, 小田 義直, 田中 雅夫

    日本外科学会雑誌   2012.3

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  • PS-007-2 胃癌におけるトラスツズマブ治療のためのHER2判定上の問題点と対応(PS-007 胃 基礎-3,ポスターセッション,第112回日本外科学会定期学術集会)

    鴻江 俊治, 久松 雄一, 神代 竜一, 中西 良太, 安藤 幸滋, 佐伯 浩司, 沖 英次, 大賀 丈史, 掛地 吉弘, 池田 哲夫, 辻谷 俊一, 相島 慎一, 前原 喜彦

    日本外科学会雑誌   2012.3

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  • PS-060-5 Tissue Tablet(組織タブレット)法 : 手術切除組織の保存・管理のための新しいアプローチ(PS-060 医療安全,第112回日本外科学会定期学術集会)

    寅田 信博, 大内田 研宙, 崔 林, 水元 一博, 相島 慎一, 小田 義直, 田中 雅夫

    日本外科学会雑誌   2012.3

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  • PS-101-7 腸型膵管内乳頭粘液性腫瘍(IPMN)由来浸潤性膵臓癌の予後が良好な理由(PS-101 膵 IPMN,ポスターセッション,第112回日本外科学会定期学術集会)

    仲田 興平, 大内田 研宙, 貞苅 良彦, 萱島 理, 相島 慎一, 水元 一博, 小田 義直, 田中 雅夫

    日本外科学会雑誌   2012.3

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  • SF-026-2 腫瘍関連マクロファージによる肝細胞癌のSignal Transducer and Activator of Transcription 3(STAT3)活性化と増殖進展における役割(SF-026 サージカルフォーラム(26)肝 基礎-2,第112回日本外科学会定期学術集会)

    間野 洋平, 相島 慎一, 吉屋 匠平, 武藤 純, 的野 る美, 本村 貴志, 戸島 剛男, 武冨 紹信, 調 憲, 前原 喜彦

    日本外科学会雑誌   2012.3

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  • SF-030-4 通常型膵癌を併存する膵管内乳頭粘液性腫瘍は胃型粘液形質を有する頻度が高い(SF-030 サージカルフォーラム(30)膵 基礎-1(発癌,癌進展),第112回日本外科学会定期学術集会)

    井手野 昇, 大塚 隆生, 小田 康徳, 河野 博, 安蘇 鉄平, 永吉 洋介, 森 泰寿, 相島 慎一, 大内田 研宙, 高畑 俊一, 中村 雅史, 水元 一博, 田中 雅夫

    日本外科学会雑誌   2012.3

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  • Total resection of the right hepatic vein drainage area with the aid of three-dimensional computed tomography.

    Akinobu Taketomi, Kazuki Takeishi, Yohei Mano, Takeo Toshima, Takashi Motomura, Shinichi Aishima, Hideaki Uchiyama, Tomoharu Yoshizumi, Ken Shirabe, Yoshihiko Maehara

    Surgery today   2012.1

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    DOI: 10.1007/s00595-011-0021-8

  • An increase in the number of predictive factors augments the likelihood of malignancy in branch duct intraductal papillary mucinous neoplasm of the pancreas.

    Takao Ohtsuka, Hiroshi Kono, Yosuke Nagayoshi, Yasuhisa Mori, Kosuke Tsutsumi, Yoshihiko Sadakari, Shunichi Takahata, Katsuya Morimatsu, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

    Surgery   2012.1

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    DOI: 10.1016/j.surg.2011.07.009

  • Uptake of Gd-EOB-DTPA by hepatocellular carcinoma: radiologic-pathologic correlation with special reference to bile production.

    Yoshiki Asayama, Tsuyoshi Tajima, Akihiro Nishie, Kousei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, Daisuke Okamoto, Nobuhiro Fujita, Shinichi Aishima, Ken Shirabe, Hiroshi Honda

    European journal of radiology   2011.12

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    DOI: 10.1016/j.ejrad.2010.10.032

  • Nuclear atypia grading score is a useful prognostic factor in papillary gastric adenocarcinoma.

    Yuichiro Nakashima, Takashi Yao, Minako Hirahashi, Shinichi Aishima, Yoshihiro Kakeji, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Histopathology   2011.11

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    DOI: 10.1111/j.1365-2559.2011.04035.x

  • Histological and immunohistological findings in biliary intraepithelial neoplasia arising from a background of chronic biliary disease compared with liver cirrhosis of non-biliary aetiology.

    Shinichi Aishima, Tomohiro Iguchi, Nobuhiro Fujita, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi, Yoshinao Oda

    Histopathology   2011.11

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    DOI: 10.1111/j.1365-2559.2011.04011.x

  • MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis.

    Kohei Nakata, Kenoki Ohuchida, Kazuhiro Mizumoto, Tadashi Kayashima, Naoki Ikenaga, Hiroshi Sakai, Cui Lin, Hayato Fujita, Takao Otsuka, Shinichi Aishima, Eishi Nagai, Yoshinao Oda, Masao Tanaka

    Surgery   2011.11

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    DOI: 10.1016/j.surg.2011.06.017

  • 広範微小肺腫瘍塞栓によって呼吸不全を来たした肝細胞癌患者の一例

    田中 紘介, 中舎 晃男, 宮崎 将之, 高尾 信一郎, 樋口 野日斗, 田中 正剛, 田中 ゆき, 加藤 正樹, 古藤 和浩, 髙栁 涼一, 相島 慎一

    福岡醫學雜誌   2011.10

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    肝細胞癌の肝外転移臓器として,肺は最も頻度の高い臓器である.CT やMR などの画像検査機器の発達により,肺転移巣の同定は容易となり,その診断に苦慮することは希である.また,肝細胞癌からの肺転移は高頻度であるにもかかわらず,呼吸不全に至る症例は少なく,多くの場合,肺転移巣が拡大して呼吸機能に影響を与えるようになる前に,原発の肝病変が進行して,肝不全に至る.今回我々は,肝細胞癌の経過観察中に,原因不明の呼吸不全が急速に進行した症例を経験した.入院時の画像検査で,肺の腫瘍性病変などの呼吸不全を来たす所見を認めず,酸素化が障害されている原因が不明であったが,死後の肺組織検査により,広範な微小腫瘍塞栓が認められた.肺の腫瘍塞栓によって,急速な呼吸不全を来たす病態として,Pulmonary tumor thrombotic microangiopathy(PTTM)があるが,本症例の病理所見では,PTTM は否定的であった.本症例の呼吸不全に関して若干の文献的考察を加えて報告する.

    DOI: 10.15017/20445

  • Cystic tumors of the liver: on the problems of diagnostic criteria.

    Yohei Mano, Shinichi Aishima, Nobuhiro Fujita, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

    Pathology, research and practice   2011.10

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    DOI: 10.1016/j.prp.2011.07.006

  • Histologic classification of microscopic portal venous invasion to predict prognosis in hepatocellular carcinoma.

    Nobuhiro Fujita, Shinichi Aishima, Tomohiro Iguchi, Yohei Mano, Akinobu Taketomi, Ken Shirabe, Hiroshi Honda, Masazumi Tsuneyoshi, Yoshinao Oda

    Human pathology   2011.10

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    DOI: 10.1016/j.humpath.2010.12.016

  • PS-129-6 腫瘍関連マクロファージによる肝細胞癌のSignal Transducer and Activated of Transcription 3 (STAT3)活性化と臨床病理学的検討(PS-129 ポスターセッション(129)肝臓:基礎-4,第111回日本外科学会定期学術集会)

    間野 洋平, 相島 慎一, 調 憲, 藤田 展宏, 武藤 純, 的野 る美, 本村 貴志, 武石 一樹, 戸島 剛男, 吉松 正憲, 伊地知 秀樹, 原田 昇, 内山 秀昭, 吉住 朋晴, 武冨 紹信, 前原 喜彦

    日本外科学会雑誌   2011.5

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  • PS-096-5 当科における大腸癌肝転移に対する術前化学療法の検討(PS-096 ポスターセッション(96)大腸:化学療法-3,第111回日本外科学会定期学術集会)

    山中 直樹, 奈良 絵津子, 安蘇 鉄平, 真鍋 達也, 植木 隆, 森松 克哉, 相島 慎一, 藤本 千夏, 馬場 英司, 田中 雅夫

    日本外科学会雑誌   2011.5

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  • Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis.

    Kohei Nakata, Kenoki Ohuchida, Shinichi Aishima, Yoshihiko Sadakari, Tadashi Kayashima, Yoshihiro Miyasaka, Eishi Nagai, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi, Yoshinao Oda

    Pancreas   2011.5

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    DOI: 10.1097/MPA.0b013e318214fa86

  • 大動脈原発 Intimal sarcoma の1例

    山田 裕一, 山元 英崇, 相島 慎一, 田宮 貞史, 西田 誉浩, 富永 隆治, 小田 義直

    診断病理 : Japanese journal of diagnostic pathology   2011.4

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  • Different roles of S100P overexpression in intrahepatic cholangiocarcinoma: carcinogenesis of perihilar type and aggressive behavior of peripheral type.

    Shinichi Aishima, Nobuhiro Fujita, Yohei Mano, Yuichiro Kubo, Yuki Tanaka, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

    The American journal of surgical pathology   2011.4

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    DOI: 10.1097/PAS.0b013e31820ffdf1

  • Prognostic significance of preoperative imaging in recipients of living donor liver transplantation for hepatocellular carcinoma.

    Keishi Sugimachi, Ken Shirabe, Akinobu Taketomi, Yuji Soejima, Tomohiro Iguchi, Kazuki Takeishi, Takeo Toshima, Shinichi Aishima, Tsuyoshi Tajima, Yoshihiko Maehara

    Transplantation   2011.3

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    DOI: 10.1097/TP.0b013e318208134e

  • Performance of radiological methods in diagnosing hepatocellular carcinoma preoperatively in a recipient of living related liver transplantation: comparison with step section histopathology.

    Masakazu Hirakawa, Kengo Yoshimitsu, Hiroyuki Irie, Tsuyoshi Tajima, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Akinobu Taketomi, Shin-ichi Aishima, Hiroshi Honda

    Japanese journal of radiology   2011.2

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    DOI: 10.1007/s11604-010-0528-8

  • Pseudo-Meigs' syndrome associated with breast cancer metastasis to both ovaries: Report of a case.

    Naonori Kawakubo, Masayuki Okido, Risa Tanaka, Kenji Mitsugi, Masao Fukuhara, Shinichi Aishima, Masato Kato, Hitoshi Ichimiya

    Surgery today   2010.12

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    DOI: 10.1007/s00595-009-4187-2

  • Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type.

    2010.12

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    Ovarian mucinous neoplasms of gastro-intestinal type (GI-type) are known to be a heterogeneous tumor composed of benign, borderline and non-invasive and invasive malignant lesions. The presence of infiltrative invasion is also known to be an important prognostic factor of this neoplasm. Laminin γ 2 chain, known to stimulate tumor cell invasion and migration, has not been sufficiently investigated in ovarian mucinous neoplasms. The purpose of this study was thus to clarify the role of laminin γ 2 in ovarian mucinous neoplasms of GI-type. We selected each morphological phase of tumor development from 61 cases of mucinous neoplasms of the GI-type: 55 adenoma lesions, 60 borderline lesions, 20 microinvasive lesions, 17 intraepithelial carcinoma lesions, 38 expansile invasive carcinoma lesions, 19 infiltrative invasive carcinoma lesions and 5 mural nodules lesions; and evaluated the localization of laminin γ 2 in the lesions using immunohistochemical method. The staining pattern was classified into i) basement membranous (BM), ii) cytoplasmic (CYT) and iii) stromal (S) pattern. The BM pattern was characteristic in adenoma, borderline, and interaepithelial and expansile invasive carcinoma lesions. The CYT and S patterns were characteristic in infiltrative invasive lesions. The staining pattern of mural nodules was similar to that of infiltrative invasion. The infiltrative invasion of GI-type ovarian mucinous neoplasms may be promoted by cytoplasmic and/or stromal expression of laminin γ 2 chain.

    DOI: 10.3892/or-00001019

  • Predictors of extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma.

    Akinobu Taketomi, Takeo Toshima, Dai Kitagawa, Takashi Motomura, Kazuki Takeishi, Yohei Mano, Hiroto Kayashima, Keishi Sugimachi, Shinichi Aishima, Yoichi Yamashita, Toru Ikegami, Tomonobu Gion, Hideaki Uchiyama, Yuji Soejima, Takashi Maeda, Ken Shirabe, Yoshihiko Maehara

    Annals of surgical oncology   2010.10

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    DOI: 10.1245/s10434-010-1076-2

  • p62+ Hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease.

    Shinichi Aishima, Nobuhiro Fujita, Yohei Mano, Tomohiro Iguchi, Akinobu Taketomi, Yoshihiko Maehara, Yoshinao Oda, Masazumi Tsuneyoshi

    American journal of clinical pathology   2010.9

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    DOI: 10.1309/AJCP53YVVJCNDZIR

  • 肝細胞腺腫の1例

    平島 浩太郎, 本田 由美, 石原 園子, 安里 嗣晴, 赤星 慎一, 近本 亮, 別府 透, 馬場 秀夫, 相島 慎一, 猪山 賢一

    診断病理 : Japanese journal of diagnostic pathology   2010.7

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  • Clinicopathological prognostic factors after hepatectomy for patients with mass-forming type intrahepatic cholangiocarcinoma: relevance of the lymphatic invasion index.

    Ken Shirabe, Yohei Mano, Akinobu Taketomi, Yuji Soejima, Hideaki Uchiyama, Shinichi Aishima, Hiroto Kayashima, Mizuki Ninomiya, Yoshihiko Maehara

    Annals of surgical oncology   2010.7

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    DOI: 10.1245/s10434-010-0929-z

  • S100P is a novel marker to identify intraductal papillary mucinous neoplasms.

    Kohei Nakata, Eishi Nagai, Kenoki Ohuchida, Akifumi Hayashi, Yoshihiro Miyasaka, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi

    Human pathology   2010.6

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    DOI: 10.1016/j.humpath.2009.11.007

  • Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinoma.

    Akifumi Hayashi, Shinichi Aishima, Takahiro Inoue, Kohei Nakata, Katsuya Morimatsu, Eishi Nagai, Yoshinao Oda, Masao Tanaka, Masazumi Tsuneyoshi

    Human pathology   2010.6

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    DOI: 10.1016/j.humpath.2009.09.018

  • Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development.

    Nobuhiro Fujita, Shinichi Aishima, Tomohiro Iguchi, Yunosuke Nishihara, Hidetaka Yamamoto, Akinobu Taketomi, Yoshinao Oda, Hiroshi Honda, Masazumi Tsuneyoshi

    Human pathology   2010.6

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    DOI: 10.1016/j.humpath.2009.11.011

  • Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from the intestinal type.

    Yoshihiko Sadakari, Kenoki Ohuchida, Kohei Nakata, Takao Ohtsuka, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

    Surgery   2010.6

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    DOI: 10.1016/j.surg.2009.11.011

  • 11.類奇形腫成分を伴った肝芽腫の1例(第39回九州地区小児固形悪性腫瘍研究会)

    孝橋,賢一, 小田,義直, 相島,慎一, 田尻,達郎, 林田,真, 田口,智章, 神薗,淳司, 小野,友輔

    小児がん : 小児悪性腫瘍研究会記録   2010.5

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  • 臨床報告 術前診断が困難であった肝硬化性血管腫の1切除例

    吉田 月久, 杉町 圭史, 祇園 智信, 副島 雄二, 相島 慎一, 武冨 紹信, 前原 喜彦

    臨床外科   2010.3

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    DOI: 10.11477/mf.1407103016

  • OP-078-2 肝内胆管癌切除症例の生存に関わる因子の解析と治療成績向上への取り組み(胆管癌治療-2,一般口演,第110回日本外科学会定期学術集会)

    本村 貴志, 間野 洋平, 調 憲, 武石 一樹, 戸島 剛男, 梅田 健一, 森田 和豊, 萱島 寛人, 二宮 瑞樹, 内山 秀昭, 副島 雄二, 武冨 紹信, 相島 慎一, 山下 洋一, 前原 喜彦

    日本外科学会雑誌   2010.3

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  • OP-257-2 腫瘤形成型を示す肝内胆管癌の浸潤形式と予後の検討(肝胆道・病理-1,一般口演,第110回日本外科学会定期学術集会)

    関野 洋平, 調 憲, 本村 貴志, 武石 和樹, 戸島 剛男, 森田 和豊, 萱島 寛人, 二宮 瑞樹, 内山 秀昭, 副島 雄二, 武冨 紹信, 相島 慎一, 前原 喜彦

    日本外科学会雑誌   2010.3

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  • Unusual multiple gastric carcinoids with hypergastrinemia: report of a case.

    Kohei Nakata, Shinichi Aishima, Hitoshi Ichimiya, Takashi Yao, Takashi Matsuura, Mitsuru Seo, Eishi Nagai, Masayuki Okido, Masato Kato, Mitsuru Nakagaki, Masazumi Tsuneyoshi, Masao Tanaka

    Surgery today   2010.3

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    DOI: 10.1007/s00595-009-4032-7

  • Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement.

    Yasuni Nakanuma, Yoh Zen, Kenichi Harada, Motoko Sasaki, Akitaka Nonomura, Takeshi Uehara, Kenji Sano, Fukuo Kondo, Toshio Fukusato, Koichi Tsuneyama, Masahiro Ito, Kenichi Wakasa, Minoru Nomoto, Hiroshi Minato, Hironori Haga, Masayoshi Kage, Hirohisa Yano, Joji Haratake, Shinichi Aishima, Tomoyuki Masuda, Hajime Aoyama, Aya Miyakawa-Hayashino, Toshiharu Matsumoto, Hayato Sanefuji, Hidenori Ojima, Tse-Ching Chen, Eunsil Yu, Ji-Hun Kim, Young Nyun Park, Wilson Tsui

    Pathology international   2010.3

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    DOI: 10.1111/j.1440-1827.2009.02500.x

  • Fascin expression in progression and prognosis of hepatocellular carcinoma.

    Tomohiro Iguchi, Shinichi Aishima, Kenji Umeda, Kensaku Sanefuji, Nobuhiro Fujita, Keishi Sugimachi, Tomonobu Gion, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Journal of surgical oncology   2009.12

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    DOI: 10.1002/jso.21377

  • CD10+ fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma.

    Yunosuke Nishihara, Shinichi Aishima, Akifumi Hayashi, Tomohiro Iguchi, Nobuhiro Fujita, Akinobu Taketomi, Hiroshi Honda, Masazumi Tsuneyoshi

    Histopathology   2009.10

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    DOI: 10.1111/j.1365-2559.2009.03398.x

  • P-1-368 肝細胞癌における被膜浸潤の新定義とその検証(肝 腫瘍基礎,一般演題(ポスター),第64回日本消化器外科学会総会)

    井口 友宏, 相島 慎一, 森田 和豊, 植田 茂, 實藤 健作, 杉町 圭史, 祇園 智信, 武冨 紹信, 前原 喜彦

    日本消化器外科学会雑誌   2009.7

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  • P-1-285 大腸癌卵巣転移によるpseudo-Meigs症候群3例の臨床病理学的検討(大腸癌症例1,一般演題(ポスター),第64回日本消化器外科学会総会)

    大西 秀哉, 相島 慎一, 松本 耕太郎, 許斐 裕之, 大城戸 政行, 加藤 雅人, 一宮 仁

    日本消化器外科学会雑誌   2009.7

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  • LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer.

    Kohei Nakata, Kenoki Ohuchida, Eishi Nagai, Akifumi Hayashi, Yoshihiro Miyasaka, Tadashi Kayashima, Jun Yu, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi

    Neoplasia (New York, N.Y.)   2009.7

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    DOI: 10.1593/neo.09418

  • Erratum: Extracapsular penetration is a new prognostic factor in human hepatocellular carcinoma (American Journal of Surgical Pathology (2008) 32 (1675-1682))

    T. Iguchi, S. Aishima, A. Taketomi

    American Journal of Surgical Pathology   2009.3

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    DOI: 10.1097/PAS.0b013e31819f584d

  • Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma.

    Shinichi Aishima, Tomohiro Iguchi, Yunosuke Nishihara, Nobuhiro Fujita, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Histopathology   2009.3

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    DOI: 10.1111/j.1365-2559.2009.03240.x

  • SF-057-1 肝内胆管癌における癌関連遺伝子発現とSurvival tree model解析による予後予測(肝(基礎研究3),サージカルフォーラム,第109回日本外科学会定期学術集会)

    井口 友宏, 山下 夏美, 相島 慎一, 實藤 健作, 杉町 圭史, 武冨 紹信, 恒吉 正澄, 前原 喜彦

    日本外科学会雑誌   2009.2

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  • SF-041-4 腸型IPMN発がん経路におけるCDX2を介したRegIVの関与(膵(IPMN),サージカルフォーラム,第109回日本外科学会定期学術集会)

    仲田 興平, 永井 英司, 大内田 研宙, 相島 慎一, 森松 克哉, 林 晃史, 宮坂 義弘, 水元 一博, 恒吉 正澄, 田中 雅夫

    日本外科学会雑誌   2009.2

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  • Fascin overexpression is involved in carcinogenesis and prognosis of human intrahepatic cholangiocarcinoma: immunohistochemical and molecular analysis.

    Tomohiro Iguchi, Shinichi Aishima, Akinobu Taketomi, Yunosuke Nishihara, Nobuhiro Fujita, Kensaku Sanefuji, Keishi Sugimachi, Yo-ichi Yamashita, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Human pathology   2009.2

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    DOI: 10.1016/j.humpath.2008.06.029

  • ヒト悪性腫瘍の病理組織形態と分子生物学的特性

    恒吉 正澄, 八尾 隆史, 小田 義直, 田宮 貞史, 相島 慎一, 山元 英崇, 大石 善丈, 平橋 美奈子, 栗原 秀一, 孝橋 賢一

    福岡醫學雜誌   2009.1

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    DOI: 10.15017/13540

  • Biliary phenotype of hepatocellular carcinoma after preoperative transcatheter arterial chemoembolization.

    Yunosuke Nishihara, Shinichi Aishima, Yousuke Kuroda, Tomohiro Iguchi, Kenichi Taguchi, Yoshiki Asayama, Akinobu Taketomi, Naoko Kinukawa, Hiroshi Honda, Masazumi Tsuneyoshi

    Journal of gastroenterology and hepatology   2008.12

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    DOI: 10.1111/j.1440-1746.2008.05601.x

  • CD10 immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium.

    Yoshihiro Ohishi, Tsunehisa Kaku, Hiroaki Kobayashi, Shinichi Aishima, Yoshihisa Umekita, Norio Wake, Masazumi Tsuneyoshi

    Human pathology   2008.10

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    DOI: 10.1016/j.humpath.2008.02.006

  • O-2-183 肝細胞癌におけるFascin発現の臨床病理学的意義(肝 研究3,一般演題(口演),第63回日本消化器外科学会総会)

    井口 友宏, 西原 雄之介, 藤田 展宏, 相島 慎一, 杉町 圭史, 山下 洋市, 武冨 紹信, 慎吉 正澄, 前原 喜彦

    日本消化器外科学会雑誌   2008.7

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  • 特集 小腸疾患2008 各論 4.全身性疾患の部分症としての小腸病変 5) 免疫不全-移植片対宿主病(graft-versus-host disease;GVHD),後天性免疫不全症候群(acquired immunodeficiency syndrome;AIDS)

    瀬尾 充, 金 玹志, 西条 寛平, 松浦 隆志, 相島 慎一, 衛藤 徹也, 中山 秀樹

    胃と腸   2008.4

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    DOI: 10.11477/mf.1403101353

  • DP-114-4 肝細胞癌におけるFascin発現の臨床病理学的意義(第108回日本外科学会定期学術集会)

    井口 友宏, 西原 雄之介, 藤田 展宏, 相島 慎一, 杉町 圭史, 山下 洋市, 武冨 紹信, 恒吉 正澄, 前原 喜彦

    日本外科学会雑誌   2008.4

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  • DP-137-4 肝内胆管癌におけるFocal Adhesion Kinase (FAK)発現の臨床的意義(第108回日本外科学会定期学術集会)

    大田 隆司, 武冨 紹信, 森田 和豊, 福原 崇介, 植田 茂, 實藤 健作, 萱島 寛人, 丸山 晴司, 杉町 圭史, 山下 洋市, 吉住 朋晴, 副島 雄二, 相島 慎一, 前原 喜彦

    日本外科学会雑誌   2008.4

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  • Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma.

    Shinichi Aishima, Yunosuke Nishihara, Tomohiro Iguchi, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc   2008.3

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    DOI: 10.1038/modpathol.3800985

  • Arterial blood supply of hepatocellular carcinoma and histologic grading: radiologic-pathologic correlation.

    Yoshiki Asayama, Kengo Yoshimitsu, Yunosuke Nishihara, Hiroyuki Irie, Shinichi Aishima, Akinobu Taketomi, Hiroshi Honda

    AJR. American journal of roentgenology   2008.1

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    DOI: 10.2214/AJR.07.2117

  • Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine.

    Nobito Higuchi, Masaki Kato, Kazuhiro Kotoh, Motoyuki Kohjima, Shinichi Aishima, Makoto Nakamuta, Yoshinori Fukui, Ryoichi Takayanagi, Munechika Enjoji

    Liver international : official journal of the International Association for the Study of the Liver   2007.12

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    DOI: 10.1111/j.1478-3231.2007.01590.x

  • P-587 ゲフィチニブで著効を得た後肺葉切除を行い良好に経過中の2例(一般演題(ポスター) 症例11,第48回日本肺癌学会総会号)

    加藤 雅人, 安蘇 鉄平, 園田 幸生, 上田 純二, 大城戸 政行, 一宮 仁, 中垣 充, 鶴田 伸子, 樋口 和行, 相島 慎一

    肺癌   2007.10

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  • Expression profile of class I histone deacetylases in human cancer tissues.

    Masamune Nakagawa, Yoshinao Oda, Takashi Eguchi, Shin-Ichi Aishima, Takashi Yao, Fumihito Hosoi, Yuji Basaki, Mayumi Ono, Michihiko Kuwano, Masao Tanaka, Masazumi Tsuneyoshi

    Oncology reports   2007.10

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    DOI: 10.3892/or.18.4.769

  • P-2-304 原発性胆汁性肝硬変を背景に発症した肝細胞癌3症例の病理学的検討(肝癌 臨床3,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

    黒田 陽介, 武冨 紹信, 相島 慎一, 北川 大, 伊藤 心二, 原田 昇, 山下 洋市, 池上 徹, 副島 雄二, 前原 喜彦

    日本消化器外科学会雑誌   2007.7

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  • Role of growth factor receptor bound protein 7 in hepatocellular carcinoma.

    Shinji Itoh, Akinobu Taketomi, Shinji Tanaka, Norifumi Harimoto, Yo-ichi Yamashita, Shin-ichi Aishima, Takashi Maeda, Ken Shirabe, Mitsuo Shimada, Yoshihiko Maehara

    Molecular cancer research : MCR   2007.7

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    DOI: 10.1158/1541-7786.MCR-06-0282

  • 14-3-3sigma negatively regulates the cell cycle, and its down-regulation is associated with poor outcome in intrahepatic cholangiocarcinoma.

    Yousuke Kuroda, Shinichi Aishima, Akinobu Taketomi, Yunosuke Nishihara, Tomohiro Iguchi, Kenichi Taguchi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Human pathology   2007.7

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    DOI: 10.1016/j.humpath.2006.12.014

  • Hepatoid adenocarcinoma of the stomach: histogenesis and progression in association with intestinal phenotype.

    Yumiko Kumashiro, Takashi Yao, Shinichi Aishima, Minako Hirahashi, Kenichi Nishiyama, Tomomi Yamada, Ryoichi Takayanagi, Masazumi Tsuneyoshi

    Human pathology   2007.6

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    DOI: 10.1016/j.humpath.2006.10.020

  • Histologic characteristics and prognostic significance in small hepatocellular carcinoma with biliary differentiation: subdivision and comparison with ordinary hepatocellular carcinoma.

    Shinichi Aishima, Yunosuke Nishihara, Yousuke Kuroda, Kenichi Taguchi, Tomohiro Iguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    The American journal of surgical pathology   2007.5

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    DOI: 10.1097/01.pas.0000213421.53750.0a

  • A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease.

    Tohru Utsunomiya, Masahiro Okamoto, Shigeki Wakiyama, Masaji Hashimoto, Kengo Fukuzawa, Takahiro Ezaki, Shinichi Aishima, Yasuji Yoshikawa, Taizo Hanai, Hiroshi Inoue, Graham-F Barnard, Masaki Mori

    World journal of gastroenterology   2007.1

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    DOI: 10.3748/wjg.v13.i3.383

  • Proposal of a new staging and grading system of the liver for primary biliary cirrhosis

    K. Hiramatsu, H. Aoyama, Y. Zen, S. Aishima, S. Kitagawa, Y. Nakanuma

    Histopathology   2006.11

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    DOI: 10.1111/j.1365-2559.2006.02537.x

  • Characteristic differences according to the cirrhotic pattern of advanced primary biliary cirrhosis: Macronodular cirrhosis indicates slow progression.

    Shinichi Aishima, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Hepatology research : the official journal of the Japan Society of Hepatology   2006.11

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    DOI: 10.1016/j.hepres.2006.07.008

  • High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma.

    Shinichi Aishima, Yuji Basaki, Yoshinao Oda, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Fumihito Hosoi, Yuichiro Maruyama, Abbas Fotovati, Shinji Oie, Mayumi Ono, Takato Ueno, Michio Sata, Hirohisa Yano, Masamichi Kojiro, Michihiko Kuwano, Masazumi Tsuneyoshi

    Cancer science   2006.11

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    DOI: 10.1111/j.1349-7006.2006.00322.x

  • Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: Gastric foveolar type is associated with aggressive tumour behaviour

    S. Aishima, Y. Kuroda, Y. Nishihara, K. Taguchi, A. Taketomi, Y. Maehara, M. Tsuneyoshi

    Histopathology   2006.7

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    DOI: 10.1111/j.1365-2559.2006.02414.x

  • 肝内胆管癌における術後予後規定因子の解析と治療戦略

    播本 憲史, 武冨 紹信, 吉住 朋晴, 内山 秀昭, 山下 洋市, 原田 昇, 北川 大, 黒田 陽介, 萱島 寛人, 相島 慎一, 前原 喜彦

    日本外科学会雑誌   2006.3

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  • Prognostic impact of cholangiocellular and sarcomatous components in combined hepatocellular and cholangiocarcinoma.

    Shinichi Aishima, Yousuke Kuroda, Yoshiki Asayama, Kenichi Taguchi, Yunosuke Nishihara, Akinobu Taketomi, Masazumi Tsuneyoshi

    Human pathology   2006.3

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    DOI: 10.1016/j.humpath.2005.08.019

  • 医学集談会 臨床病理検討会(肺癌を合併した特発性間質性肺炎の1例)

    金田 章子, 松永 悠子, 相島 慎一

    共済医報   2006.2

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    記事種別: 会議・学会報告・シンポジウム

  • 今月の症例 胃inflammatory fibroid polypの1例

    檜沢 一興, 中原 束, 住吉 康平, 森山 智彦, 松本 主之, 飯田 三雄, 相島 慎一, 八尾 隆史

    胃と腸   2006.2

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    DOI: 10.11477/mf.1403100265

  • [Mechanism of biliary carcinogenesis: Hepatotropic hepatis virus].

    Kenichi Taguchi, Shinichi Aishima, Masazumi Tsuneyoshi

    Nihon rinsho. Japanese journal of clinical medicine   2006.1

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  • Significance of the relationship between irregular regeneration and two hepatocarcinogenic pathways: "de novo" and so-called "dysplastic nodule-hepatocellular carcinoma" sequence.

    Kenichi Taguchi, Shinichi Aishima, Shuji Matsuura, Takahiro Terashi, Kenichi Nishiyama, Ken Shirabe, Mitsuo Shimada, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Journal of surgical oncology   2005.11

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    DOI: 10.1002/jso.20293

  • サイトメガロウイルス感染症と出血性直腸潰瘍を合併した成人スチル病の1例

    檜沢 一興, 相島 慎一, 八尾 隆史, 中原 束, 松本 主之, 飯田 三雄

    日本消化器病学会雑誌   2005.10

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    症例は84歳女性.成人スチル病の診断でステロイド治療中に大量下血を生じ,2003年6月4日,当科緊急入院となった.直腸に巨大潰瘍あり,生検組織像にて虚血性変化と薬剤性粘膜障害の所見を認めた.さらにCMVantigenemia陽性のためgancyclovir併用し,中心静脈栄養療法を継続した.経過中antigenemia再上昇にともない下血が再燃した.gancyclovir継続後は下血なく,2004年3月16日,成人スチル病のため死亡した.

    DOI: 10.11405/nisshoshi.102.1281

  • 'Scirrhous' type hepatocellular carcinomas: A special reference to expression of cytokeratin 7 and hepatocyte paraffin 1

    S. Matsuura, S. Aishima, K. Taguchi, Y. Asayama, T. Terashi, H. Honda, Masazumi Tsuneyoshi

    Histopathology   2005.10

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    DOI: 10.1111/j.1365-2559.2005.02230.x

  • Bronchiolitis obliterans organizing pneumonia as an initial manifestation in systemic lupus erythematosus.

    Hidetoshi Takada, Yusuke Saito, Akihiko Nomura, Shouichi Ohga, Kazuyoshi Kuwano, Nobutaka Nakashima, Shinichi Aishima, Noboru Tsuru, Toshiro Hara

    Pediatric pulmonology   2005.9

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    DOI: 10.1002/ppul.20224

  • LMD法とDNAマイクロアレイ法による肝細胞癌の癌化進展関連遺伝子についての検討(肝臓10, 第60回日本消化器外科学会総会)

    岡本 正博, 宇都宮 徹, 原口 直紹, 三森 功士, 田中 文明, 脇山 茂樹, 福澤 謙吾, 相島 慎一, 井上 裕, 森 正樹

    日本消化器外科学会雑誌   2005.7

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  • Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement.

    Yoh Zen, Shinichi Aishima, Yoichi Ajioka, Joji Haratake, Masayoshi Kage, Fukuo Kondo, Yuji Nimura, Michiie Sakamoto, Motoko Sasaki, Kazuhide Shimamatsu, Kenichi Wakasa, Young Nyun Park, Ming F Chen, Yutaka Atomi, Yasuni Nakanuma

    Pathology international   2005.4

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    DOI: 10.1111/j.1440-1827.2005.01816.x

  • Detection of combined hepatocellular and cholangiocarcinomas on enhanced CT: comparison with histologic findings.

    Akihiro Nishie, Kengo Yoshimitsu, Yoshiki Asayama, Hiroyuki Irie, Hitoshi Aibe, Tsuyoshi Tajima, Kenji Shinozaki, Tomohiro Nakayama, Daisuke Kakihara, Mitsuo Shimada, Shin-Ichi Aishima, Kisaku Yoshida, Hiroshi Honda

    AJR. American journal of roentgenology   2005.4

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    DOI: 10.2214/ajr.184.4.01841157

  • バルプロ酸ナトリウムにより高アンモニア血症をきたしたC型慢性肝炎の1例

    福嶋 真理恵, 古藤 和浩, 遠城寺 宗近, 中牟田 誠, 名和田 新, 相島 慎一

    日本消化器病学会雑誌   2005.1

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    症例は45歳,男性.平成10年より慢性硬膜血腫術後のてんかん発作にて,近医経過観察中,高アンモニア血症を指摘され,平成13年5月当科に紹介入院.HCV-RNA陽性だが肝予備能低下なく,門脈大循環へのシャントなく,アミノ酸分析正常であった.薬剤の関与としてバルプロ酸ナトリウムが考えられ,減量中止したところアンモニア値は改善した.基礎病変として肝疾患を持つ症例においても,常に薬剤による高アンモニア血症に考慮して診療にあたるべきと考えられた.

    DOI: 10.11405/nisshoshi.102.42, 10.2957/kanzo.59.421_references_DOI_7iqc9gI6LrFzakFaQecy4g2pG30

  • Aberrant expression of laminin gamma 2 chain and its prognostic significance in intrahepatic cholangiocarcinoma according to growth morphology Reviewed

    Shinichi Aishima, Shuji Matsuura, Takahiro Terashi, Kenichi Taguchi, Mitsuo Shimada, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Modern Pathology   2004.8

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    DOI: 10.1038/modpathol.3800143

  • The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C.

    Norifumi Harimoto, Mitsuo Shimada, Shin-ichi Aishima, Dai Kitagawa, Shinji Itoh, Eiji Tsujita, Shin-ichiro Maehara, Akinobu Taketomi, Shinji Tanaka, Ken Shirabe, Yoshihiko Maehara

    Liver international : official journal of the International Association for the Study of the Liver   2004.8

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    DOI: 10.1111/j.1478-3231.2004.0927.x

  • OP-3-018 肝細胞癌におけるDGKθ発現の生物学的意義に関する研究(肝9)

    武冨 紹信, 島田 光生, 辻田 英司, 相島 慎一, 北川 大, 田中 真二, 調 憲, 前原 喜彦

    日本消化器外科学会雑誌   2004.7

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  • Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma.

    Shinji Itoh, Takashi Maeda, Mitsuo Shimada, Shin-ichi Aishima, Ken Shirabe, Shinji Tanaka, Yoshihiko Maehara

    Clinical cancer research : an official journal of the American Association for Cancer Research   2004.4

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    DOI: 10.1158/1078-0432.CCR-1046-03

  • Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis.

    Ken Shirabe, Mitsuo Shimada, Eiji Tsujita, Shin-ichi Aishima, Shin-ichiroh Maehara, Sinji Tanaka, Kenji Takenaka, Yoshihiko Maehara

    American journal of surgery   2004.4

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    DOI: 10.1016/j.amjsurg.2003.12.044

  • SF-048-5 肝細胞癌におけるシグナル伝達物質Grb7発現の検討

    伊藤 心二, 島田 光生, 田中 真二, 調 憲, 武冨 紹信, 相島 慎一, 前原 喜彦

    日本外科学会雑誌   2004.3

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  • Decreased expression of osteopontin is related to tumor aggressiveness and clinical outcome of intrahepatic cholangiocarcinoma.

    Takahiro Terashi, Shinichi Aishima, Kenichi Taguchi, Yoshiki Asayama, Keishi Sugimachi, Shuji Matsuura, Mitsuo Shimada, Shinichiro Maehara, Yoshihiko Maehara, Masazumi Tsuneyoshi

    Liver international : official journal of the International Association for the Study of the Liver   2004.2

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    DOI: 10.1111/j.1478-3231.2004.00886.x

  • 懇話会 第376回 北九州肝臓病懇話会

    天ヶ瀬 洋正, 相島 慎一, 梶原 英二

    臨牀と研究 = The Japanese journal of clinical and experimental medicine   2003.11

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    Language:Japanese  

    記事種別: 特集 ; 会議・学会報告・シンポジウム

  • Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma

    K. Sugimachi, S. Tanaka, K. Taguchi, S. Aishima, M. Shimada, K. Sugimachi, M. Tsuneyoshi

    Journal of Clinical Pathology   2003.11

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    DOI: 10.1136/jcp.56.11.854

  • 肝細胞癌におけるfocal adhesion kinaseの生物学的意義に関する研究

    伊藤 心二, 島田 光生, 前田 貴司, 相島 慎一, 田中 真二, 調 憲, 恒吉 正澄, 前原 喜彦

    日本消化器外科学会雑誌   2003.7

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  • 特集 全身性疾患と消化管病変 総論 4. 病理学的側面からみた全身性疾患と消化管病変

    八尾 隆史, 西山 憲一, 相島 慎一, 恒吉 正澄

    胃と腸   2003.4

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    DOI: 10.11477/mf.1403100899

  • Sarcomatous hepatocellular carcinoma: a special reference to ordinary hepatocellular carcinoma.

    Hidehiro Nishi, Ken-ichi Taguchi, Yoshiki Asayama, Shin-ichi Aishima, Keishi Sugimachi, Hajime Nawata, Masazumi Tsuneyoshi

    Journal of gastroenterology and hepatology   2003.4

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    DOI: 10.1046/j.1440-1746.2003.02888.x

  • Coexpression of neural cell adhesion molecules and bcl-2 in intrahepatic cholangiocarcinoma originated from viral hepatitis: relationship to atypical reactive bile ductule.

    Yoshiki Asayama, Shin-Ichi Aishima, Ken-Ichi Taguchi, Keishi Sugimachi, Shuji Matsuura, Kouji Masuda, Masazumi Tsuneyoshi

    Pathology international   2002.4

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    DOI: 10.1046/j.1440-1827.2002.01349.x

  • The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma.

    Shin-ichi Aishima, Ken-ichi Taguchi, Keishi Sugimachi, Yoshiki Asayama, Hidehiro Nishi, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

    International journal of surgical pathology   2002.1

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    DOI: 10.1177/106689690201000108

  • Intrahepatic cholangiocarcinoma: its mode of spreading and therapeutic modalities.

    Ken Shirabe, Mitsuo Shimada, Norifumi Harimoto, Keishi Sugimachi, Yo-ichi Yamashita, Eiji Tsujita, Shin-ichi Aishima

    Surgery   2002.1

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    DOI: 10.1067/msy.2002.119498

  • S05-04 肝内胆管癌に対する切除の問題点と戦略

    調 憲, 島田 光生, 竹中 賢治, 田中 真二, 山下 洋市, 相島 慎一, 杉町 圭蔵

    日本消化器外科学会雑誌   2001.7

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  • The role of des-γ-carboxy prothrombin levels in hepatocellular carcinoma and liver tissues

    2000.10

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    We aimed to clarify the clinical significance of des-γ-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC, who underwent hepatectomy, were studied. Surgical specimens were obtained from both HCC and non-cancerous liver of each patient. After the preparation of the liver tissues, including tissues with HCC, the DCP levels both in HCC and non-cancerous liver tissue were measured using an electro-chemiluminescence immunoassay. The correlation was investigated between DCP levels and other clinicopathological factors. The DCP level of HCC ranged from 55 to 77 735 U/0.1 g tissue weight, with a median of 2801, while the DCP level of non-cancerous parts of the liver ranged from 24 to 721 U/0.1 g tissue weight, with a median of 86. The DCP level in the liver tissue in patients having a multicentric occurrence of HCC was significantly higher than that in patients without multicentric occurrence of HCC. The logarithm of the plasma DCP level correlated with that of the DCP level in HCC (correlation coefficient = 0.46; P < 0.05). No significant correlation was found between the DCP level in HCC and other clinicopathological parameters. The DCP level in non-cancerous parts of the liver with simultaneous multicentric occurrence of HCC was significantly higher than that in the liver without multicentric HCC. Furthermore, the DCP level in non-cancerous parts of the liver was one of the most important predictable factors of the multicentric occurrence of HCCs among various clinicopathological factors. Therefore, the DCP level may have an important role in hepatocarcinogenesis. (C) 2000 Elsevier Science Ireland Ltd.

    DOI: 10.1016/S0304-3835(00)00539-5

  • Clinicopathologic features and postoperative prognosis of multicentric small hepatocellular carcinoma

    Tohru Utsunomiya, Mitsuo Shimada, Ken Ichi Taguchi, Hirofumi Hasegawa, Yoichi Yamashita, Takayuki Hamatsu, Shin Ichi Aishima, Keizo Sugimachi

    Journal of the American College of Surgeons   2000.3

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    DOI: 10.1016/S1072-7515(99)00268-9

  • W2-3 肝細胞癌におけるMAGE遺伝子の発現および再発関連因子としての検討

    濱津 隆之, 島田 光生, 宇都宮 徹, 田口 健一, 長谷川 博文, 山下 洋市, 相島 慎一, 調 憲, 杉町 圭蔵

    日本消化器外科学会雑誌   1999.6

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  • W7-2 小肝細胞癌に対する外科治療戦略 : 径3cm未満単発小肝細胞癌の肝切除成績の検討

    濱津 隆之, 島田 光生, 宇都宮 徹, 祇園 智信, 田口 健一, 長谷川 博文, 山下 洋市, 相島 慎一, 杉町 圭蔵

    日本消化器外科学会雑誌   1999.2

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  • 664 5生率から高度進行肝癌の治療戦略

    山下 洋市, 島田 光生, 宇都宮 徹, 祇園 智信, 田口 健一, 長谷川 博文, 相島 慎一, 濱津 隆之, 杉町 圭蔵

    日本消化器外科学会雑誌   1999.2

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  • S6-4 再発肝細胞癌に対する戦略 : 再切除における予後因子の検討から

    島田 光生, 宇都宮 徹, 祇園 智信, 田口 健一, 長谷川 博文, 山下 洋市, 濱津 隆之, 相島 慎一, 竹中 賢治, 杉町 圭蔵

    日本消化器外科学会雑誌   1999.2

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Professional Memberships

  • 日本外科学会

  • 日本消化器外科学会

  • 日本病理学会

  • 日本癌学会

  • 日本肝臓学会

  • 日本臨床細胞学会

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Research Projects

  • 肝内胆管癌のサブタイプ別にみる分子異常と免疫微小環境の包括的研究

    Grant number:22K06942  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 直接抗ウイルス剤によるウイルス排除後肝癌における免疫微小環境の病理学的研究

    Grant number:19K07462  2019 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • ミニチュアヒト肝臓を用いた肝癌の浸潤・転移機序解明による革新的肝癌治療の開発

    Grant number:16K10586  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 肝・胆道癌の発癌・進展における鉄代謝関連蛋白発現調節機構の病理学的解明

    Grant number:15K08347  2015 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 肝癌の微小環境における炎症の機序解明とPD-1シグナル制御による革新的治療の開発

    Grant number:24390320  2012 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 胆管癌における胆管レベルによる発癌・進展機構の違い:胆汁酸受容体と糖代謝に関して

    Grant number:23590399  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 慢性肝炎・肝硬変に生じる肝内胆管癌の発癌機構の解明

    Grant number:21790355  2009 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 肝細胞癌浸潤・転移におけるFascin蛋白の機能解析とその臨床応用

    Grant number:20591614  2008 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 肝内胆管癌の浸潤・転移における細胞接着分子の発現とその制御機構の解明

    Grant number:17790237  2005

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 肝内胆管癌の浸潤転移

    2003 - 2004

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 肝内胆管癌における多段階発癌・発育進展機序の解明

    Grant number:15790187  2003 - 2004

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

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Class subject

  • 病理学総論 老化 皮膚・膠原病

    2024.4 - 2024.9   First semester

  • 病理学各論 肝胆膵病理学

    2023.10 - 2024.3   Second semester

FD Participation

  • 2024.3   Role:Participation   Title:大学病院の苦悩と医学研究の課題

    Organizer:[Undergraduate school/graduate school/graduate faculty]

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  群馬大学・医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:令和6年4月23日

Other educational activity and Special note

  • 2024  Class Teacher