Faculty Profiles - AISHIMA SHINICHI

Information

写真a

AISHIMA SHINICHI

Organization

Faculty of Medical Sciences Department of Basic Medicine Professor
Kyushu University Hospital Division of Diagnostic Pathology（Concurrent）
School of Medicine Department of Medicine（Concurrent）
Graduate School of Medical Sciences Department of Medicine（Concurrent）
Graduate School of Medical Sciences Department of Medical Sciences（Concurrent）

Contact information

Tel

0926426060

Profile

Pathological research for liver, biliary system and pancreas

External link

Research Areas

Life Science / Human pathology

Degree

The Role of Thymidine Phosphorylase and Thrombospondin-1 in Angiogenesis and Progression of Intrahepatic Cholangiocarcinoma

Research History

九州大学大学院病態制御学講座構造病態病理学分野教授

2023.7 - Present

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佐賀大学医学部病因病態科学講座診断病理学分野

2014.2 - 2023.6

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国家公務員共済組合連合会　浜の町病院　病理医長 2005年4月～2008年3月

国家公務員共済組合連合会　浜の町病院　病理医長 2005年4月～2008年3月
佐賀大学医学部　病因病態科学講座診断病理学分野　教授 2014年2月～2023年6月

Education

Kyushu University

- 2002

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Country： Japan

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Saga Medical School

- 1996

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Country： Japan

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Research Interests・Research Keywords

Research theme：肝・胆・膵病理学

Keyword：肝・胆・膵病理学

Research period： 2024
Research theme：Liver carcinogenesis of NBNC background Liver carcinogenesis of MASLD Tumor microenvironment of intrahepatic cholangiocarcinoma Premalignant condition of gallbladder cancer

Keyword：Bile duct cancer, liver cancer

Research period： 2023.9 - 2023.12

Awards

学術奨励賞

2010.9 日本癌学会
学術研究賞（A演説）

2007.11 日本病理学会

Papers

Novel method for classification of prion diseases by detecting PrP<sup>res</sup> signal patterns from formalin-fixed paraffin-embedded samples International journal

Sachiko Koyama, Kaoru Yagita, Hideomi Hamasaki, Hideko Noguchi, Masahiro Shijo, Kosuke Matsuzono, Kei Ichiro Takase, Keita Kai, Shin Ichi Aishima, Kyoko Itoh, Toshiharu Ninomiya, Naokazu Sasagasako, Hiroyuki Honda

Prion 18 ( 1 ) 40 - 53 2024.12 （ ISSN:1933-6896 eISSN:1933-690X ）

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Prion disease is an infectious and fatal neurodegenerative disease. Western blotting (WB)-based identification of proteinase K (PK)-resistant prion protein (PrPres) is considered a definitive diagnosis of prion diseases. In this study, we aimed to detect PrPres using formalin-fixed paraffin-embedded (FFPE) specimens from cases of sporadic Creutzfeldt–Jakob disease (sCJD), Gerstmann–Sträussler–Scheinker disease (GSS), glycosylphosphatidylinositol-anchorless prion disease (GPIALP), and V180I CJD. FFPE samples were prepared after formic acid treatment to inactivate infectivity. After deparaffinization, PK digestion was performed, and the protein was extracted. In sCJD, a pronounced PrPres signal was observed, with antibodies specific for type 1 and type 2 PrPres exhibited a strong or weak signals depending on the case. Histological examination of serial sections revealed that the histological changes were compatible with the biochemical characteristics. In GSS and GPIALP, prion protein core-specific antibodies presented as PrPres bands at 8–9 kDa and smear bands, respectively. However, an antibody specific for the C-terminus presented as smears in GSS, with no PrPres detected in GPIALP. It was difficult to detect PrPres in V180I CJD. Collectively, our findings demonstrate the possibility of detecting PrPres in FFPE and classifying the prion disease types. This approach facilitates histopathological and biochemical evaluation in the same sample and is safe owing to the inactivation of infectivity. Therefore, it may be valuable for the diagnosis and research of prion diseases.

DOI： 10.1080/19336896.2024.2337981

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Validation study of age-independent fibrosis score (Fibrosis-3 index) in patients with metabolic dysfunction-associated steatotic liver disease International journal

Kazuhiro Nouso, Miwa Kawanaka, Hideki Fujii, Kazuya Kariyama, Hidenori Toyoda, Michihiro Iwaki, Hideki Hayashi, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takashi Kumada, Takeshi Okanoue

Hepatology Research 54 ( 10 ) 912 - 920 2024.10 （ ISSN:1386-6346 eISSN:1872-034X ）

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Background and Aims: Because the accuracy of the Fibrosis-4 (FIB-4) index for predicting liver fibrosis changes with age, the need for different cut-offs in various age groups has frequently been discussed. We developed the age-independent score, the Fibrosis-3 (FIB-3) index, and have shown its usefulness in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to validate the diagnostic ability of the FIB-3 index to predict fibrosis progression using a large new patient cohort. Methods: The ability of the FIB-3 index to predict liver fibrosis was analyzed by comparing it with that of the FIB-4 index using data from 1398 patients with MASLD enrolled in the Asia-based clinical outcome NAFLD study. Results: The areas under the receiver operating characteristic curves for predicting fibrosis stage F3 or higher were not different between the FIB-3 and FIB-4 indices in the entire cohort. Using the single ideal cut-offs of the indices (3.41 for FIB-3 index and 2.01 for FIB-4 index), the predictive accuracy of the FIB-3 index was not significantly different from that of the FIB-4 index among patients aged <60 years; however, the accuracy of the FIB-3 index was significantly higher than that of the FIB-4 index in those aged ≥60 years (0.645 and 0.529, respectively; p < 0.0001). Conclusion: The high ability of the FIB-3 index with a single cut-off to predict liver fibrosis in patients with MASLD was confirmed. The FIB-3 index could serve as a useful tool for assessing liver fibrosis regardless of age.

DOI： 10.1111/hepr.14039

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後腹膜に嚢胞状転移巣を形成した,非常に稀な顎下腺腺様嚢胞癌の1例

三根夢花, 甲斐敬太, 北村捷, 川崎佳奈子, 山内盛泰, 馬塲耕一, 倉富勇一郎, 能城浩和, 末岡榮三朗, 相島慎一

日本臨床細胞学会九州連合会雑誌 55 47 - 51 2024.7 （ ISSN:0912-6600 ）

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Language：Japanese Publisher：日本臨床細胞学会-九州連合会

背景腺様嚢胞癌の遠隔転移は肺や骨が多く,後腹膜転移は稀である.今回,後腹膜に嚢胞状腫瘤を形成し,臨床的に乳癌の転移が疑われたが,嚢胞内容液の細胞診で顎下腺原発腺様嚢胞癌の後腹膜転移と推定しえた1例を経験したので報告する.症例 60歳代女性.右側腹部腫瘤を主訴に前医を受診し,精査により右骨盤部後腹膜に骨破壊を伴う嚢胞性腫瘍と左乳房腫瘤を指摘された.左乳房腫瘤は生検で乳癌(浸潤性乳管癌)の診断となり,加療目的に当院紹介となった.後腹膜腫瘍に対しては乳癌転移疑いとして穿刺吸引細胞診が施行されたが,腺様嚢胞癌を疑う異型細胞を認めるも確定診断には至らなかった.その後MRIで左顎下腺に長径約5cm大の腫瘤が認められ,穿刺吸引細胞診で腺様嚢胞癌の診断となった.後腹膜腫瘍が乳癌の転移か,腺様嚢胞癌の転移かの鑑別目的に,再度嚢胞内容液の穿刺吸引細胞診が施行され,腺様嚢胞癌の後腹膜転移の診断となった.結語腺様嚢胞癌はその特徴的な細胞形態に着目し,ギムザ染色やセルブロックによる免疫組織化学を加味することで細胞診検体による推定が可能である.自験例の様に,腺様嚢胞癌は転移好発臓器以外にも転移巣を形成することがあるので,細胞診判定の際には留意が必要である.(著者抄録)
Fulminant demyelinating disease of the central nervous system effectively treated with a combination of decompressive craniectomy and immunotherapy: A case report and literature review. International journal

Toshihiro Ide, Ryo Ebashi, Makoto Eriguchi, Shinichi Aishima, Tatsuya Abe, Hideo Hara

Clinical case reports 12 ( 7 ) e9059 2024.7

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KEY CLINICAL MESSAGE: Accurately identifying fulminant demyelinating diseases is important for sudden onset of asymmetric cerebral white matter lesions with mass effect. Initially, immunotherapy should be administered; however, surgical intervention should be performed with poor response to medical management and evident signs of cerebral herniation. ABSTRACT: A case of fulminant demyelinating disease of the central nervous system that required decompressive craniectomy 8 days after symptom onset is presented. The patient recovered without sequelae after a combination of neurosurgery and immunotherapy with steroids and has remained relapse-free for 4 years.

DOI： 10.1002/ccr3.9059

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Hepatic inflammation and fibrosis are profiles related to mid-term mortality in biopsy-proven MASLD: A multicenter study in Japan International journal

Tsubasa Tsutsumi, Takumi Kawaguchi, Hideki Fujii, Yoshihiro Kamada, Hirokazu Takahashi, Miwa Kawanaka, Yoshio Sumida, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Shinichiro Ueda, Shinichi Aishima, Atsushi Nakajima, Takeshi Okanoue

Alimentary Pharmacology and Therapeutics 59 ( 12 ) 1559 - 1570 2024.6 （ ISSN:0269-2813 eISSN:1365-2036 ）

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Aims: A multi-stakeholder consensus has proposed MASLD (metabolic dysfunction-associated steatotic liver disease). We aimed to investigate the pathological findings related to the mid-term mortality of patients with biopsy-proven MASLD in Japan. Methods: We enrolled 1349 patients with biopsy-proven MASLD. The observational period was 8010 person years. We evaluated independent factors associated with mortality in patients with MASLD by Cox regression analysis. We also investigated pathological profiles related to mortality in patients with MASLD using data-mining analysis. Results: The prevalence of MASH and stage 3/4 fibrosis was observed in 65.6% and 17.4%, respectively. Forty-five patients with MASLD died. Of these, liver-related events were the most common cause at 40% (n = 18), followed by extrahepatic malignancies at 26.7% (n = 12). Grade 2/3 lobular inflammation and stage 3/4 fibrosis had a 1.9-fold and 1.8-fold risk of mortality, respectively. In the decision-tree analysis, the profiles with the worst prognosis were characterised by Grade 2/3 hepatic inflammation, along with advanced ballooning (grade 1/2) and fibrosis (stage 3/4). This profile showed a mortality at 8.3%. Furthermore, the random forest analysis identified that hepatic fibrosis and inflammation were the first and second responsible factors for the mid-term prognosis of patients with MASLD. Conclusions: In patients with biopsy-proven MASLD, the prevalence of MASH and advanced fibrosis was approximately 65% and 20%, respectively. The leading cause of mortality was liver-related events. Hepatic inflammation and fibrosis were significant factors influencing mid-term mortality. These findings highlight the importance of targeting inflammation and fibrosis in the management of patients with MASLD.

DOI： 10.1111/apt.17995

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Importance of ALT levels of >30 in patients with MASLD: Nara Declaration 2023

Kawanaka Miwa, Fujii Hideki, Iwaki Michihiro, Hayashi Hideki, Toyoda Hidenori, Oeda Satoshi, Hyogo Hideyuki, Morishita Asahiro, Munekage Kensuke, Kawata Kazuhito, Tsutsumi Tsubasa, Sawada Koji, Maeshiro Tatsuji, Tobita Hiroshi, Yoshida Yuichi, Naito Masafumi, Araki Asuka, Arakaki Shingo, Kawaguchi Takumi, Noritake Hidenao, Ono Masafumi, Masaki Tsutomu, Yasuda Satoshi, Tomita Eiichi, Yoneda Masato, Tokushige Akihiro, Kamada Yoshihiro, Takahashi Hirokazu, Ueda Shinichiro, Aishima Shinichi, Sumida Yoshio, Okanoue Takeshi, Nakajima Atsushi, Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD)

Kanzo 65 ( 4 ) 186 - 191 2024.4 （ ISSN:04514203 eISSN:18813593 ）

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Language：Japanese Publisher：The Japan Society of Hepatology

Importance of ALT levels of >30 in patients with MASLD: Nara Declaration 2023
The Nara Declaration 2023 recommends that patients with ALT levels of >30 U/L and those who have steatosis, diabetes, hypertension, and/or dyslipidemia should be referred to a hepatologist, considering the results of the FIB4 index and/or platelet count. ALT levels of >30 U/L is a simple and useful indicator and, when combined with the FIB4 index and platelet count, can detect MASLD cases that require further treatment and follow-up. Moreover, among patients with MAFLD and ALT levels of ≤30 U/L, the FIB4 index may be useful for identifying those at risk of MASLD. The Nara Declaration 2023 is an important and convenient guideline that provides primary care doctors with specific indications for referral to a hepatologist. When combined with the FIB4 index, ALT levels of >30 U/L is expected to predict high-risk MASLD cases.

DOI： 10.2957/kanzo.65.186

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Accuracy of the Enhanced Liver Fibrosis Test in Patients With Type 2 Diabetes Mellitus and Its Clinical Implications Reviewed International journal

@Arai T, @Takahashi H, @Seko Y, @Toyoda H, @Hayashi H, @Yamaguchi K, @Iwaki M, @Yoneda M, @Shima T, @Fujii H, @Morishita A,@Kawata K, @Tomita K, @Kawanaka M, @Yoshida Y, @Ikegami T, @Notsumata K, @Oeda S, @Atsukawa M, @Kamada Y, @Sumida Y, @Fukushima H, @Miyoshi E, Aishima S, @Okanoue T, @Itoh Y, @Nakajima A; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).

Clin Gastroenterol Hepatol. 2024 22 ( 4 ) 789 - 797 2024.4

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DOI： 10.1016/j.cgh.2023.11.022.
Prognosis of biopsy-confirmed metabolic dysfunction-associated steatotic liver disease: A sub-analysis of the CLIONE study

Michihiro Iwaki, Hideki Fujii, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Clinical and Molecular Hepatology 30 ( 2 ) 225 - 234 2024.4 （ ISSN:2287-2728 eISSN:2287-285X ）

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Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) was recently proposed as an alternative disease concept to nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the prognosis of patients with biopsy-confirmed MASLD using data from a multicenter study. Methods: This was a sub-analysis of the Clinical Outcome Nonalcoholic Fatty Liver Disease (CLIONE) study that included 1,398 patients with NAFLD. Liver biopsy specimens were pathologically diagnosed and histologically scored using the NASH Clinical Research Network system, the FLIP algorithm, and the SAF score. Patients who met at least one cardiometabolic criterion were diagnosed with MASLD. Results: Approximately 99% of cases (n=1,381) were classified as MASLD. Patients with no cardiometabolic risk (n=17) had a significantly lower BMI than patients with MASLD (20.9 kg/m2 vs. 28.0 kg/m2, P<0.001), in addition to significantly lower levels of inflammation, ballooning, NAFLD activity score, and fibrosis stage based on liver histology. These 17 patients had a median follow-up of 5.9 years, equivalent to 115 person-years, with no deaths, liver-related events, cardiovascular events, or extrahepatic cancers. The results showed that the prognosis for pure MASLD was similar to that for the original CLIONE cohort, with 47 deaths and one patient who underwent orthotopic liver transplantation. The leading cause of death was extrahepatic cancer (n=10), while the leading causes of liver-related death were liver failure (n=9), hepatocellular carcinoma (n=8), and cholangiocarcinoma (n=4). Conclusions: Approximately 99% of NAFLD cases were considered MASLD based on the 2023 liver disease nomenclature. The NAFLD-only group, which is not encompassed by MASLD, had a relatively mild histopathologic severity and a favorable prognosis. Consequently, the prognosis of MASLD is similar to that previously reported for NAFLD.

DOI： 10.3350/cmh.2023.0515

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Interobserver agreement of pathologic classification and grading of tumoral intraductal pre-invasive neoplasms of the bile duct

Yasuni Nakanuma, Yasunori Sato, Yuko Kakuda, Yoshiki Naito, Yuki Fukumura, Mana Fukushima, Hiroshi Minato, Shinichi Aishima, Nobuyuki Ohike, Toru Furukawa

Annals of Diagnostic Pathology 69 152247 2024.4 （ ISSN:1092-9134 eISSN:1532-8198 ）

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Current WHO terminology and recent publications have classified tumoral (grossly visible) intraductal pre-invasive neoplasms of bile duct (TIDN) into three categories: intraductal papillary neoplasm of bile duct (IPNB), intraductal papillary oncocytic neoplasm (IOPN), and intraductal tubulopapillary neoplasm (ITPN). A total of 227 cases of TIDN and related lesions ≥3 mm in height were examined by 10 biliary pathologists referring to these 3 categories and two pathologic gradings: two-tiered system (low- and high-grade dysplasia) and modified types 1 and 2 subclassification. Among them, IPNB was the most frequent (183 cases), followed by IOPN (28 cases), while ITPN was rare (2 cases), and interobserver agreement in this classification was “substantial” (κ-value, 0.657). The interobserver agreement of two-tiered grading system of TIDN was “slight” (κ-value, 0.201), while that of modified types 1 and 2 subclassification was “moderate” (κ-value, 0.515), and 42 % were of type 1, and 58 % were of type 2. Type 1 TIDN showed occasional stromal invasion (6.7 %), whereas type 2 TIDN was frequently associated with stromal invasion (49.6 %) (p < 0.01). In conclusion, the classification of TIDN into three categories and modified types 1 and 2 subclassification are a practically applicable classification and grading system for TIDN.

DOI： 10.1016/j.anndiagpath.2023.152247

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Accuracy of the Enhanced Liver Fibrosis Test in Patients With Type 2 Diabetes Mellitus and Its Clinical Implications

Taeang Arai, Hirokazu Takahashi, Yuya Seko, Hidenori Toyoda, Hideki Hayashi, Kanji Yamaguchi, Michihiro Iwaki, Masato Yoneda, Toshihide Shima, Hideki Fujii, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Yuichi Yoshida, Tadashi Ikegami, Kazuo Notsumata, Satoshi Oeda, Masanori Atsukawa, Yoshihiro Kamada, Yoshio Sumida, Hideaki Fukushima, Eiji Miyoshi, Shinichi Aishima, Takeshi Okanoue, Yoshito Itoh, Atsushi Nakajima

Clinical Gastroenterology and Hepatology 22 ( 4 ) 789 - 797.e8 2024.4 （ ISSN:1542-3565 eISSN:1542-7714 ）

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Background and Aims: The diagnostic performance of the Fibrosis-4 (FIB-4) index and nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) is poor in patients with type 2 diabetes mellitus (T2DM). We determined the usefulness of the Enhanced Liver Fibrosis (ELF) test in patients with T2DM. Methods: A total of 1228 patients with biopsy-proven NAFLD were enrolled. The diagnostic performance of the ELF test for predicting advanced fibrosis in participants with or without T2DM was evaluated in comparison with the FIB-4 index and NFS. Results: Overall, the area under the curve of the ELF test for predicting advanced fibrosis was greater (0.828) than that of the FIB-4 index (0.727) and NFS (0.733). The diagnostic performance of the ELF test (area under the curve, 0.820) was also superior to that of the FIB-4 index (0.698) and NFS (0.700) in patients with T2DM. With the low cutoff values for each noninvasive test, the ELF test provided an acceptable false negative rate (cutoff value 9.8, 6.7%) in this population, unlike the FIB-4 index (1.30, 14.5%) and NFS (−1.455, 12.4%). After propensity score matching to avoid selection bias including age, sex, body mass index, and the prevalence of advanced fibrosis, the ELF test with a low cutoff value showed a high sensitivity (≥91.4%) and a high negative predictive value (≥96.8%), irrespective of the presence or absence of T2DM. Conclusions: The high diagnostic performance of the ELF test for predicting advanced fibrosis in individuals with or without T2DM could address an unmet medical need for accurate assessment of liver fibrosis in patients with diabetes and NAFLD.

DOI： 10.1016/j.cgh.2023.11.022

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奈良宣言(ALT over 30)のMASLD(metabolic dysfunction-associated steatotic liver disease)における臨床的意義の検証

川中美和, 藤井英樹, 岩城慶大, 林秀樹, 豊田秀徳, 大枝敏, 兵庫秀幸, 森下朝洋, 宗景玄祐, 川田一仁, 堤翼, 澤田康司, 前城達次, 飛田博史, 吉田雄一, 内藤雅文, 荒木亜寿香, 新垣伸吾, 川口巧, 則武秀尚, 小野正文, 正木勉, 安田諭, 冨田栄一, 米田正人, 徳重明央, 鎌田佳宏, 高橋宏和, 植田真一郎, 相島慎一, 角田圭雄, 岡上武, 中島淳, Japan Study Group of Nonalcoholic Fatty Liver Disease(JSG-NAFLD)

肝臓 65 ( 4 ) 186 - 191 2024.4 （ ISSN:0451-4203 ）

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Language：Japanese Publisher：(一社)日本肝臓学会

肝生検を施行されたMASLD(metabolic dysfunction-associated steatotic liver disease)における「ALT>30U/L」の有用性とその意義についてFIB-4 Index、血小板数を組み合わせて検討した。1994年12月～2020年12月に肝生検を施行されたNAFLD(Non-alcoholic fatty liver disease)1398例のうちMASLDに該当する1381例を対象とした。stage≧2は614例に認め、そのうちALT>50U/Lは470例(76%)であった。ALT>30U/LにすることによりALT30～50U/Lの症例を追加で拾い上げることができ、stage≧2は578例(94%)とより多くの線維化進展したMASLDの検出が可能となった。FIB-4 IndexでみてみるとFIB-4 Index>1.3は全体で805症例に認められたが、ALT>50U/Lから>30U/Lに基準値を変えることにより、572例(71%)から742例(92%)に検出可能症例が増加した。同様に血小板20×10^4/μL未満の557例においてもALT>50U/Lから>30U/Lにすることにより367例(66%)から509例(91%)の症例も検出可能となった。FIB-4 Indexと血小板を組み合わせることにより、治療適応になるMASLD症例の取りこぼしが少なくすることが期待された。
A rare case of liver regenerative and non-neoplastic lesion resembling a well-differentiated hepatocellular carcinoma

Hirose, K; Toshima, T; Tobo, T; Kai, S; Hirakawa, M; Higuchi, S; Ofuchi, T; Hosoda, K; Yonemura, Y; Hisamatsu, Y; Masuda, T; Aishima, S; Mimori, K

SURGICAL CASE REPORTS 10 ( 1 ) 30 2024.2 （ ISSN:2198-7793 ）

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DOI： 10.1186/s40792-024-01820-1

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高分化型肝細胞癌との鑑別に苦慮した肝再生性非腫瘍性病変の稀な1例(A rare case of liver regenerative and non-neoplastic lesion resembling a well-differentiated hepatocellular carcinoma)

Hirose Kosuke, Toshima Takeo, Tobo Taro, Kai Satohiro, Hirakawa Masakazu, Higuchi Satoshi, Ofuchi Takashi, Hosoda Kiyotaka, Yonemura Yusuke, Hisamatsu Yuichi, Masuda Takaaki, Aishima Shinichi, Mimori Koshi

Surgical Case Reports 10 1 of 6 - 6 of 6 2024.2

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49歳男性。特に既往や家族歴、飲酒歴、ウイルス感染歴などなかった。定期検診の腹部超音波検査で肝S7/8に2cm径の腫瘍および軽度の脂肪肝を伴う低エコー病変が認められた。単純CTでは高吸収域を示した。MRIでは、腫瘍はT1強調画像で境界部に高信号、内部に低信号を呈し、T2強調画像では低信号を示した。Gd-EOB-DTPA造影MRIでは、病変に脂肪が含まれており、EOB取り込みも認められた。以上より高分化型肝細胞癌(HCC)を疑い、腹腔鏡下S7/8部分切除術を施行した。患者は術後10日目に合併症なく退院した。病理組織検査の結果、過形成性病変や腺腫などの腫瘍性病変は認められず、肝小葉壊死を伴う再生性肝変化と診断した。
副鼻腔原発神経内分泌癌の1例

宮本晃多, 江頭玲子, 福井修一, 入江裕之, 佐藤有記, 木戸伸一, 相島慎一

Japanese Journal of Radiology 42 ( Suppl. ) 49 - 49 2024.2 （ ISSN:1867-1071 eISSN:1867-108X ）

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Comparison of the treatment effect between lenvatinib and atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma in pathologically diagnosed metabolic dysfunction-associated steatotic liver disease

Takahashi, H; Koshiyama, Y; Mitsumoto, Y; Kobayashi, T; Hayashi, H; Arai, T; Sawada, K; Nonaka, M; Nakahara, T; Tomita, K; Ito, T; Notsumata, K; Seko, Y; Fujii, H; Aishima, S; Yoneda, M; Toyoda, H; Sumida, Y; Nakajima, A; Okanoue, T

JOURNAL OF CLINICAL ONCOLOGY 42 ( 3_SUPPL ) 493 - 493 2024.1 （ ISSN:0732-183X eISSN:1527-7755 ）

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DOI： 10.1200/JCO.2024.42.3_suppl.493

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CTを契機に発見された消化管AL型アミロイドーシスの一例

西田大輝, 芥川剛至, 藤田真衣, 沖井詩織, 水田優実, 島村拓弥, 行元崇浩, 相島慎一, 江崎幹宏

日本消化管学会雑誌 8 ( Suppl. ) 376 - 376 2024.1 （ ISSN:2433-3840 eISSN:2435-8967 ）

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Collision tumor of a papillary and follicular thyroid carcinoma: a case report

Kanako Kawasaki, Keita Kai, Nariyuki Tanaka, Shinichi Kido, Arisa Ibi, Akimichi Minesaki, Moriyasu Yamauchi, Yuichiro Kuratomi, Shinichi Aishima, Masahiro Nakashima, Masahiro Ito

Thyroid Research 16 ( 1 ) 2023.12 （ eISSN:1756-6614 ）

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Background: Papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) are common differentiated thyroid cancers, but the detection of a collision tumor is an extremely rare event. Case presentation: The patient was a 69-year-old Japanese female with multiple cervical lymph node swellings and a thyroid tumor. Preoperative fine needle aspiration cytology of the enlarged lymph node revealed a cytological diagnosis of papillary thyroid carcinoma (PTC). A total thyroidectomy, right cervical dissection and paratracheal dissection were performed. Histopathological and immunohistochemical analyses of resected specimens revealed a collision tumor of PTC and FTC. Multiple metastases of papillary carcinoma were found in the dissected lymph nodes. In the PTC lesion, IHC for BRAF (V600E) was positive but negative for the FTC lesion. Genetic analyses further revealed a TERT promoter C228T mutation in PTC and a NRAS codon 61 mutation in FTC. The patient died of recurrent cancer 8 months after surgery. Conclusions: A case of a collision tumor of PTC and FTC is very rare, and even fewer cases have been subjected to genetic scrutiny. The present case was successfully diagnosed by pathological examination using immunohistochemical and genetic analyses. The TERT promoter mutation in the PTC lesion was consistent with the aggressive behavior of the cancer.

DOI： 10.1186/s13044-023-00167-3

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Pseudohypercreatininemia after surgery for aortic dissection: a case report

Ayako Tasaki, Makoto Fukuda, Yuki Ikeda, Masatora Yamasaki, Ikko Yamaguchi, Shinichi Aishima, Motoaki Miyazono

BMC Nephrology 24 ( 1 ) 2023.12 （ eISSN:1471-2369 ）

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Background: Elevated creatinine concentrations often indicate acute renal injury and renal biopsies are considered in this situation. However,pseudohypercreatininemia is potential cause of elevated creatinine concentrations, and invasive interventions should be avoided. Case presentation: A 54-year-old woman underwent surgery for descending aortic dissection.Nine days postoperatively, her creatinine concentration increased from 1 mg/dl to 5.78 mg/dl (normal range, 0.47–0.7 mg/dl). Azotemia and hyperkalemia were absent and physical examination findings were unremarkable. Cystatin C concentration was 1.56 mg/l (normal range, 0.56–0.8 mg/l) and pseudohypercreatininemia was suspected. Testing with different reagents showed a creatinine concentration of 0.84 mg/dl. Immunoglobulin (Ig)G was markedly elevated, and creatinine and IgG fluctuated in parallel, suggesting the cause of the pseudohypercreatininemia. IgG4 was also elevated at 844 mg/dl. Immunosuppressive steroid therapy effectively decreased the IgG concentration and resolved the pseudohypercreatininemia. Conclusions: In cases of elevated creatinine concentration with the presence of abnormal proteins, pseudohypercreatininemia should be considered. We report a rare case of pseudohypercreatininemia caused by polyclonal IgG.

DOI： 10.1186/s12882-023-03275-2

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Subcutaneous angiogenesis induced by transdermal delivery of gel-in-oil nanogel dispersion

Yi Zhang, Jannatul Fardous, Yuuta Inoue, Ryota Doi, Asami Obata, Yusuke Sakai, Shinichi Aishima, Hiroyuki Ijima

Biomaterials Advances 154 213628 2023.11 （ eISSN:2772-9508 ）

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Subcutaneous transplantation aims to enhance the growth and functionality of transplanted cells for therapeutic outcomes in tissue engineering. However, the limited subcutaneous vascular network poses a challenge. Conventional methods involve co-transplantation with endothelial cells or angiogenic scaffold implantation, but they have drawbacks like tissue inflammation, compromised endothelial cell functionality, and the risk of repeated scaffold transplantation. Effective techniques are needed to overcome these challenges. This study explores the potential of G/O-NGD, a gel-in-oil nanogel dispersion, as a transdermal carrier of proliferative factors to promote angiogenesis in subcutaneous graft beds before cell transplantation. We observed robust subcutaneous angiogenesis by delivering varying amounts of bFGF using the G/O-NGD emulsion. Quantitative analysis of several parameters confirmed the efficacy of this method for building a subcutaneous vascular network. G/O-NGD is a biodegradable material that facilitates localized transdermal delivery of bFGF while maintaining its activity. The findings of this study have significant implications in both medical and industrial fields.

DOI： 10.1016/j.bioadv.2023.213628

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肝胆道領域の病理診断

相島慎一

日本臨床細胞学会雑誌 62 ( Suppl.2 ) 409 - 409 2023.10

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増大号｢胃と腸｣式読影問題集2023 応用と発展-考える画像診断が身につく全消化管 3 Cases Case 3

芥川剛至, 沖井詩織, 島村拓弥, 相島慎一, 江﨑幹宏

胃と腸 58 ( 10 ) 1434 - 1437 2023.10

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DOI： 10.11477/mf.1403203389
Agile 3+ and Agile 4, noninvasive tests for liver fibrosis, are excellent formulae to predict liver-related events in nonalcoholic fatty liver disease

Kouichi Miura, Hideki Hayashi, Yoshihiro Kamada, Hideki Fujii, Hirokazu Takahashi, Satoshi Oeda, Michihiro Iwaki, Takumi Kawaguchi, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Hepatology Research 53 ( 10 ) 978 - 988 2023.10 （ ISSN:1386-6346 eISSN:1872-034X ）

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Aim: The noninvasive tests (NITs) Agile 3+ and Agile 4 effectively identify patients with nonalcoholic fatty liver disease (NAFLD) complicated with advanced fibrosis (F3–4) and cirrhosis (F4), respectively. Little information is available on associations between Agile scores and intra-/extrahepatic events. The aim of this study was to determine the predictive performance of Agile scores for intra-/extrahepatic events in Asian patients with biopsy-proven NAFLD. Methods: We undertook a retrospective multicenter cohort study to investigate associations between intra-/extrahepatic events and two Agile scores, Agile 3+ and Agile 4. The scores were obtained by combining clinical parameters and liver stiffness measurement using transient elastography. Results: Among 403 enrolled patients, 11 had liver-related events (LREs), including seven with hepatocellular carcinoma (HCC). The incidence of LREs and HCC showed a stepwise increase in the advanced fibrosis group (F3–4), Agile 3+ rule-in (F3–4, highly suspected), and Agile 4 rule-in (F4, highly suspected) groups, compared to their counterparts. Hazard ratios for LREs in the advanced fibrosis group, Agile 3+ rule-in, and Agile 4 rule-in groups were 4.05 (p = 0.03), 23.5 (p = 0.003), and 45.5 (p < 0.001), respectively. The predictive performance results for Agile 3+ and Agile 4 were 0.780 and 0.866, respectively, which were higher than for fibrosis (0.595). Unlike for LREs, Agile scores failed to identify patients with extrahepatic events, including cardiovascular events and extrahepatic cancer. Conclusions: Agile 3+ and Agile 4 scores are excellent NITs for predicting LREs in patients with NAFLD, possibly without histological assessment.

DOI： 10.1111/hepr.13938

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Palisading Adenocarcinoma: A Morphologically Unique Salivary Gland Tumor with a Neuroendocrine-like Appearance and a Predilection for the Sublingual Glands of Women

Justin A. Bishop, Ilan Weinreb, Chris Van Vliet, Connull Leslie, Yoshitaka Utsumi, Shinichi Aishima, Junichi Shiraishi, Masamichi Koyama, Yoshiharu Nara, Masatomo Kimura, Doreen Palsgrove, Ying Ju Kuo, Ralph Gilbert, Jeffrey Gagan, Masato Nakaguro, Toshitaka Nagao

American Journal of Surgical Pathology 47 ( 10 ) 1176 - 1185 2023.10 （ ISSN:0147-5185 eISSN:1532-0979 ）

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Adenocarcinoma, not otherwise specified (NOS) is a heterogenous group of salivary gland tumors that likely contains distinct tumors that have not yet been characterized. Indeed, in recent years, cases previously diagnosed as adenocarcinoma, NOS have been recategorized into novel tumor designations such as secretory carcinoma, microsecretory adenocarcinoma, and sclerosing microcystic adenocarcinoma. We sought to describe a distinctive, hitherto-undescribed salivary gland tumor encountered in the authors' practices. Cases were pulled from the surgical pathology archives of the authors' institutions. Histologic, immunohistochemical, and clinical findings were tabulated, and targeted next-generation sequencing was performed on all cases. Nine cases were identified, arising in 8 women and 1 man ranging from 45 to 74 years (mean, 56.7 y). Seven tumors (78%) arose in the sublingual gland, while 2 (22%) arose in the submandibular gland. The cases shared a distinctive morphologic appearance. They were biphasic, with ducts scattered among a predominant polygonal cell with round nuclei, prominent nucleoli, and pale eosinophilic cytoplasm. These cells were arranged as trabeculae and palisaded as pseudorosettes around hyalinized stroma and vessels, resembling a neuroendocrine tumor. Four of the cases were well-circumscribed, while the remaining 5 showed infiltrative growth including perineural invasion in 2 (22%) and lymphovascular invasion in 1 (11%). Mitotic rates were low (mean, 2.2/10 HPFs); necrosis was absent. By immunohistochemistry, the predominant cell type was strongly positive for CD56 (9 of 9) and variably positive for pan-cytokeratin (AE1/AE3) (7 of 9) with patchy S100 (4 of 9), but negative for synaptophysin (0 of 9) and chromogranin (0 of 9), while the ducts were strongly positive for pan-cytokeratin (AE1/AE3) (9 of 9) and CK5/6 (7 of 7). Next-generation sequencing did not reveal any fusions or obvious driver mutations. All cases were resected surgically, with external beam radiation also done in 1 case. Follow-up was available in 8 cases; there were no metastases or recurrences after 4 to 160 months (mean, 53.1 mo). A dual population of scattered ducts with a predominance of CD56-positive neuroendocrine-like cells characterizes a unique salivary gland tumor which is often encountered in the sublingual glands of women, for which we propose the term "palisading adenocarcinoma." Although the tumor was biphasic and had a neuroendocrine-like appearance, it lacked convincing immunohistochemical evidence of myoepithelial or neuroendocrine differentiation. Although a subset showed unequivocally invasive growth, this tumor appears to behave in an indolent manner. Moving forward, recognition of palisading adenocarcinoma and its separation from other salivary adenocarcinomas, NOS will facilitate a better understanding of the characteristics of this previously unrecognized tumor.

DOI： 10.1097/PAS.0000000000002091

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Identification of clinical phenotypes associated with poor prognosis in patients with nonalcoholic fatty liver disease via unsupervised machine learning

Takanori Ito, Hikaru Morooka, Hirokazu Takahashi, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Masatoshi Ishigami, Yoshihiro Kamada, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Journal of Gastroenterology and Hepatology (Australia) 38 ( 10 ) 1832 - 1839 2023.10 （ ISSN:0815-9319 eISSN:1440-1746 ）

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Background and Aims: Both fibrosis status and body weight are important for assessing prognosis in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to identify population clusters for specific clinical outcomes based on fibrosis-4 (FIB-4) index and body mass index (BMI) using an unsupervised machine learning method. Methods: We conducted a multicenter study of 1335 biopsy-proven NAFLD patients from Japan. Using the Gaussian mixture model to divide the cohort into clusters based on FIB-4 index and BMI, we investigated prognosis for these clusters. Results: The cohort consisted of 223 cases (16.0%) with advanced fibrosis (F3–4) as assessed from liver biopsy. Median values of BMI and FIB-4 index were 27.3 kg/m2 and 1.67. The patients were divided into four clusters by Bayesian information criterion, and all-cause mortality was highest in cluster d, followed by cluster b (P = 0.001). Regarding the characteristics of each cluster, clusters d and b presented a high FIB-4 index (median 5.23 and 2.23), cluster a presented the lowest FIB-4 index (median 0.78), and cluster c was associated with moderate FIB-4 level (median 1.30) and highest BMI (median 34.3 kg/m2). Clusters a and c had lower mortality rates than clusters b and d. However, all-cause of death in clusters a and c was unrelated to liver disease. Conclusions: Our clustering approach found that the FIB-4 index is an important predictor of mortality in NAFLD patients regardless of BMI. Additionally, non-liver-related diseases were identified as the causes of death in NAFLD patients with low FIB-4 index.

DOI： 10.1111/jgh.16326

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肝線維化の非侵襲性検査であるAgile 3+とAgile 4は非アルコール性脂肪性肝疾患における肝関連イベントを予測する優れた式である(Agile 3+ and Agile 4, noninvasive tests for liver fibrosis, are excellent formulae to predict liver-related events in nonalcoholic fatty liver disease)

Miura Kouichi, Hayashi Hideki, Kamada Yoshihiro, Fujii Hideki, Takahashi Hirokazu, Oeda Satoshi, Iwaki Michihiro, Kawaguchi Takumi, Tomita Eiichi, Yoneda Masato, Tokushige Akihiro, Ueda Shinichiro, Aishima Shinichi, Sumida Yoshio, Nakajima Atsushi, Okanoue Takeshi

Hepatology Research 53 ( 10 ) 978 - 988 2023.10 （ ISSN:1386-6346 ）

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アジア人の非アルコール性脂肪性肝疾患(NAFLD)における肝内/肝外イベントに対するAgileスコアの予測能を明らかにするため、多施設共同後ろ向きコホート研究を実施した。対象はNAFLD患者403例(男性40.2%、年齢中央値60歳)で、Agile 3+ rule-in患者は145例、Agile 4 rule-in患者は46例であった。11例が肝関連イベント(LRE)を経験した(肝細胞癌7例)。進行線維症(F3～4)群、Agile 3+ rule-in群、Agile 4 rule-in群におけるLREのハザード比はそれぞれ4.05(p=0.03)、23.5(p=0.003)、45.5(p<0.001)であった。Agile 3+とAgile 4の予測性能は線維症よりも高かった。肝外イベントとして、主要有害心血管イベントが7件、心血管疾患が7件、肝外癌イベントが11件あった。Agileスコアは肝外イベント患者を同定できなかった。
A Case of Multicystic Biliary Hamartoma with a Marked Peribiliary Gland Component Successfully Treated by Purely Laparoscopic Anatomical Liver Resection

Keita Kai, Takao Ide, Tomokazu Tanaka, Kumpei Yukimoto, Hiroyuki Irie, Hirokazu Noshiro, Shinichi Aishima

Journal of Gastrointestinal Cancer 54 ( 3 ) 996 - 999 2023.9 （ ISSN:1941-6628 eISSN:1941-6636 ）

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Background: Multicystic biliary hamartoma (MCBH) is an extremely rare benign liver lesion characterized by a gross well-circumscribed multicystic honeycomb appearance. This report presents a MCBH case with a marked peribiliary gland component which showed unusual histology. Case Presentation: A 63-year-old Japanese male was admitted to our hospital for a detailed examination of a hepatic cystic lesion, which was originally detected 14 years ago and had slowly enlarged. A preoperative imaging study revealed a well-demarcated multicystic lesion without communication to the biliary tracts. The possible clinical diagnoses were mucinous cystic neoplasm (MCN) or MCBH. The lesion was successfully resected by purely laparoscopic right anterior sectionectomy. The cut surfaces of resected specimens grossly exhibited a well-circumscribed multicystic lesion with a thick septum. Histologically, the cyst wall was covered by cuboidal epithelial cells resembling epithelium of the bile duct while abundant small ducts, which morphologically resembled peribiliary glands, were observed among the fibrous stroma of the thick septum. Although possible pathological diagnosis varied, including intrahepatic cholangiocarcinoma, intraductal papillary neoplasm of the bile duct, biliary adenofibroma, MCN and MCBH, the lesion was finally diagnosed as MCBH with a marked peribiliary gland component. Conclusions: MCBH can contain abundant peribiliary glands in the fibrous stroma. A pathologist should be careful not to diagnose such peribiliary glands in MCBH as neoplastic glands.

DOI： 10.1007/s12029-022-00893-1

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M-PAST score is better than MAST score for the diagnosis of active fibrotic nonalcoholic steatohepatitis

Kento Imajo, Yusuke Saigusa, Takashi Kobayashi, Koki Nagai, Shinya Nishida, Nobuyoshi Kawamura, Hiroyoshi Doi, Michihiro Iwaki, Asako Nogami, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Hiroyuki Kirikoshi, Satoshi Yasuda, Hidenori Toyoda, Hideki Hayashi, Shigehiro Kokubu, Daisuke Utsunomiya, Hirokazu Takahashi, Shinichi Aishima, Beom Kyung Kim, Nobuharu Tamaki, Satoru Saito, Masato Yoneda, Rohit Loomba, Atsushi Nakajima

Hepatology Research 53 ( 9 ) 844 - 856 2023.9 （ ISSN:1386-6346 eISSN:1872-034X ）

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Background: Clinical trials enroll patients with active fibrotic nonalcoholic steatohepatitis (NASH) (nonalcoholic fatty liver disease [NAFLD] activity score ≥ 4) and significant fibrosis (F ≥ 2); however, screening failure rates are high following biopsy. We developed new scores to identify active fibrotic NASH using FibroScan and magnetic resonance imaging (MRI). Methods: We undertook prospective primary (n = 176), retrospective validation (n = 169), and University of California San Diego (UCSD; n = 234) studies of liver biopsy-proven NAFLD. Liver stiffness measurement (LSM) using FibroScan or magnetic resonance elastography (MRE), controlled attenuation parameter (CAP), or proton density fat fraction (PDFF), and aspartate aminotransferase (AST) were combined to develop a two-step strategy—FibroScan-based LSM followed by CAP with AST (F-CAST) and MRE-based LSM followed by PDFF with AST (M-PAST)—and compared with FibroScan-AST (FAST) and MRI-AST (MAST) for diagnosing active fibrotic NASH. Each model was categorized using rule-in and rule-out criteria. Results: Areas under receiver operating characteristic curves (AUROCs) of F-CAST (0.826) and M-PAST (0.832) were significantly higher than those of FAST (0.744, p = 0.004) and MAST (0.710, p < 0.001). Following the rule-in criteria, positive predictive values of F-CAST (81.8%) and M-PAST (81.8%) were higher than those of FAST (73.5%) and MAST (70.0%). Following the rule-out criteria, negative predictive values of F-CAST (90.5%) and M-PAST (90.9%) were higher than those of FAST (84.0%) and MAST (73.9%). In the validation and UCSD cohorts, AUROCs did not differ significantly between F-CAST and FAST, but M-PAST had a higher diagnostic performance than MAST. Conclusions: The two-step strategy, especially M-PAST, showed reliability of rule-in/-out for active fibrotic NASH, with better predictive performance compared with MAST. This study is registered with ClinicalTrials.gov (number, UMIN000012757).

DOI： 10.1111/hepr.13927

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Histological validation of atrial structural remodelling in patients with atrial fibrillation

Yuya Takahashi, Takanori Yamaguchi, Toyokazu Otsubo, Kana Nakashima, Kodai Shinzato, Ryosuke Osako, Shigeki Shichida, Yuki Kawano, Akira Fukui, Atsushi Kawaguchi, Shinichi Aishima, Tsunenori Saito, Naohiko Takahashi, Koichi Node

European Heart Journal 44 ( 35 ) 3339 - 3353 2023.9 （ ISSN:0195-668X eISSN:1522-9645 ）

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Background and Aims: This study aimed to histologically validate atrial structural remodelling associated with atrial fibrillation. Methods and results: Patients undergoing atrial fibrillation ablation and endomyocardial atrial biopsy were included (n = 230; 67 ± 12 years old; 69 women). Electroanatomic mapping was performed during right atrial pacing. Voltage at the biopsy site (Vbiopsy), global left atrial voltage (VGLA), and the proportion of points with fractionated electrograms defined as ≥5 deflections in each electrogram (%Fractionated EGM) were evaluated. SCZtotal was calculated as the total width of slow conduction zones, defined as regions with a conduction velocity of <30 cm/s. Histological factors potentially associated with electroanatomic characteristics were evaluated using multiple linear regression analyses. Ultrastructural features and immune cell infiltration were evaluated by electron microscopy and immunohistochemical staining in 33 and 60 patients, respectively. Fibrosis, intercellular space, myofibrillar loss, and myocardial nuclear density were significantly associated with Vbiopsy (P =. 014, P <. 001, P <. 001, and P =. 002, respectively) and VGLA (P =. 010, P <. 001, P =. 001, and P <. 001, respectively). The intercellular space was associated with the %Fractionated EGM (P =. 001). Fibrosis, intercellular space, and myofibrillar loss were associated with SCZtotal (P =. 028, P <. 001, and P =. 015, respectively). Electron microscopy confirmed plasma components and immature collagen fibrils in the increased intercellular space and myofilament lysis in cardiomyocytes, depending on myofibrillar loss. Among the histological factors, the severity of myofibrillar loss was associated with an increase in macrophage infiltration. Conclusion: Histological correlates of atrial structural remodelling were fibrosis, increased intercellular space, myofibrillar loss, and decreased nuclear density. Each histological component was defined using electron microscopy and immunohistochemistry studies.

DOI： 10.1093/eurheartj/ehad396

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活動性線維化非アルコール性脂肪性肝炎の診断にはMASTスコアよりM-PASTスコアが適している(M-PAST score is better than MAST score for the diagnosis of active fibrotic nonalcoholic steatohepatitis)

Imajo Kento, Saigusa Yusuke, Kobayashi Takashi, Nagai Koki, Nishida Shinya, Kawamura Nobuyoshi, Doi Hiroyoshi, Iwaki Michihiro, Nogami Asako, Honda Yasushi, Kessoku Takaomi, Ogawa Yuji, Kirikoshi Hiroyuki, Yasuda Satoshi, Toyoda Hidenori, Hayashi Hideki, Kokubu Shigehiro, Utsunomiya Daisuke, Takahashi Hirokazu, Aishima Shinichi, Kim Beom Kyung, Tamaki Nobuharu, Saito Satoru, Yoneda Masato, Loomba Rohit, Nakajima Atsushi

Hepatology Research 53 ( 9 ) 844 - 856 2023.9 （ ISSN:1386-6346 ）

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活動性線維化非アルコール性脂肪性肝炎(NASH)を識別する新たなスコアを検討した。肝生検で証明された非アルコール性脂肪性肝疾患(NAFLD)患者の前向きコホート(176例)、後ろ向き検証コホート(169例)、カリフォルニア大学サンディエゴ校(UCSD)コホート(234例)を解析した。2段階の診断法F-CAST[FibroScanで測定した肝硬度(LSM)の後に制御減衰パラメータ(CAP)+アスパラギン酸アミノトランスフェラーゼ(AST)]およびM-PAST[磁気共鳴エラストグラフィー(MRE)で測定したLSMの後にプロトン密度脂肪分画(PDFF)+AST]を、FibroScan-AST(FAST)およびMRI-AST(MAST)と比較した。rule-in基準に従うと、F-CAST(81.8%)とM-PAST(81.8%)の陽性的中率はFAST(73.5%)とMAST(70.0%)より高かった。rule-out基準に従うと、F-CAST(90.5%)とM-PAST(90.9%)の陰性的中率はFAST(84.0%)とMAST(73.9%)より高かった。検証コホートとUCSDコホートではF-CASTとFASTのROC曲線下面積に有意差はなかったが、M-PASTの診断性能はMASTより高かった。以上より、活動性線維化NASHの診断においてM-PASTはMASTより優れた性能を示した。
Prediction of Liver-Related Events With a Combination of Liver Stiffness Measurements and Controlled Attenuation Parameters in Japanese Patients With Biopsy-Proven Non-alcoholic Fatty Liver Disease

Hideki Hayashi, Yoshihiro Kamada, Hideki Fujii, Hirokazu Takahashi, Satoshi Oeda, Michihiro Iwaki, Takumi Kawaguchi, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Ultrasound in Medicine and Biology 49 ( 7 ) 1658 - 1664 2023.7 （ ISSN:0301-5629 eISSN:1879-291X ）

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Objective: Liver stiffness measurements (LSMs) and controlled attenuation parameters (CAPs) obtained using vibration-controlled transient elastography (VCTE) are recognized non-invasive methods of assessing liver histology. The usefulness of CAP for predicting liver-related events (LREs: hepatocellular carcinoma, decompensation, bleeding varices) is not well understood worldwide. Our aim was to re-evaluate the cutoff values of LSM/CAP in Japan and to examine whether LSM/CAP can predict LRE. Methods: Japanese NAFLD patients (n = 403) who underwent both liver biopsy and VCTE were enrolled. We determined optimal cutoff values of LSM/CAP diagnoses for fibrosis stage and steatosis grade and investigated their clinical outcome based on LSM/CAP values. Results: The LSM cutoff values for F1 to F4 are 7.1, 7.9, 10.0 and 20.2 kPa, and the CAP cutoff values for S1 to S3 are 230, 282 and 320 dB/m. During a median follow-up of 2.7 y (range: 0.0–12.5 y), 11 patients developed LREs. The incidence of LREs in the LSM Hi (≥8.7) group was significantly higher than that in the LSM Lo (<8.7) group (p = 0.003), and the incidence in the CAP Lo (<295) group was higher than that in CAP Hi (≥295) group (p = 0.018). Considering LSM and CAP together, the risk of LRE was higher in the LSM Hi CAP Lo group than in the LSM Hi CAP Hi group (p = 0.03). Conclusion: We set LSM/CAP cutoff values to diagnose liver fibrosis and steatosis in Japan. Our study determined that NAFLD patients with high LSM and low CAP values are at high risk for LREs.

DOI： 10.1016/j.ultrasmedbio.2023.03.023

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穿刺吸引細胞診で悪性を疑った好酸性細胞型濾胞腺腫の一例

井樋有紗, 甲斐敬太, 中村光男, 川崎佳奈子, 石田知也, 峯崎晃充, 山内盛泰, 武市幸奈, 倉富勇一郎, 相島慎一

日本臨床細胞学会九州連合会雑誌 54 49 - 53 2023.7 （ ISSN:0912-6600 ）

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背景甲状腺好酸性細胞型濾胞腺腫は75%以上が好酸性細胞からなる濾胞腺腫の1亜型である.時に核異型が目立つが,組織学的な良悪性診断は通常の濾胞腺腫に準じる.今回,穿刺吸引細胞診(Fine-needle Aspiration:FNA)で悪性を疑った甲状腺好酸性細胞型濾胞腺腫の一例を経験した.症例 60代男性.甲状腺左葉の約3cm大の腫瘤に対し,FNAが施行された.FNA検体ではライトグリーン好性の顆粒状細胞質と著明な核の大小不同を有する異型細胞が出現しており,悪性と判断するも組織型推定に窮した.切除の方針となり,甲状腺左葉切除検体が術中迅速に提出された.迅速時の捺印細胞診でも術前FNAと同様の異型細胞を認めたが,凍結標本の組織所見と肉眼所見とを併せて「好酸性細胞型濾胞性腫瘍を疑うが良悪性の判定困難」と報告した.切除検体の組織学的検討では,p53の核内発現率とKi-67標識率より悪性のポテンシャルが示唆されたが,悪性の根拠たる被膜・脈管侵襲は認めず,好酸性細胞型濾胞腺腫の最終診断とした.結語甲状腺のFNA検体で好酸性細胞を示唆するライトグリーン好性の顆粒状細胞質を認めた場合,好酸性細胞型濾胞腺腫の可能性を考慮して慎重な良悪性判定を行う必要がある.(著者抄録)
Noninvasive tests predict liver-related events and mortality in patients with nonalcoholic fatty liver disease: sub-analysis of the CLIONE-Asia study

Hiroshi Ishiba, Yoshio Sumida, Yoshihiro Kamada, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Atsushi Nakajima, Takeshi Okanoue

Journal of Gastroenterology and Hepatology (Australia) 38 ( 6 ) 896 - 904 2023.6 （ ISSN:0815-9319 eISSN:1440-1746 ）

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Background and Aims: Noninvasive tests (NITs) have prognostic potential, but whether NITs are comparable with liver biopsy is unclear. This study aimed to examine the prognostic accuracy of NITs for liver-related mortality (LRM) and events (LREs) in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD). Methods: We investigated 1313 patients with NAFLD. Patients were assigned to low-risk, indeterminate-risk, and high-risk groups using conventional cutoff values of each FIB-4 and NAFLD fibrosis score (NFS) and to stage 0–2 and stage 3–4 groups using the fibrosis stage. Survival and Cox regression analyses of the prognostic potential of NITs for LRM/LREs were conducted. Results: During a median follow-up of 4.5 years, regarding to FIB-4, the incidence rate (/1000 person-years) in the low risk was zero for LRM and 0.5 for LREs. In contrast, the rate in stage 0–2 was 1.3 for LRM and 2.8 for LRE. The adjusted hazard ratios (aHRs) for LREs in the high risk compared with the low risk were 32.85 (P < 0.01). The aHRs in stage 3–4 compared with stage 0–2 were 2.68 (P = 0.02) for LREs and 2.26 (P = 0.582) for LRM. In the same fibrosis stage, the incidence of LRM/LREs was more frequent with a higher risk stratification. The same trend was observed for NFS. Conclusions: NITs accurately predict LRM and LREs as well as a liver biopsy in Japanese patients with NAFLD. Patients in the low risk may not require close follow-up for at least 5 years. The simple NITs could be an acceptable alternative method to performing a liver biopsy for the prognosis of NAFLD.

DOI： 10.1111/jgh.16144

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Validation of the utility of Agile scores to identify advanced fibrosis and cirrhosis in Japanese patients with nonalcoholic fatty liver disease

Satoshi Oeda, Yuya Seko, Hideki Hayashi, Taeang Arai, Michihiro Iwaki, Masato Yoneda, Toshihide Shima, Kazuo Notsumata, Tadashi Ikegami, Hideki Fujii, Hidenori Toyoda, Kouichi Miura, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Hiroshi Isoda, Kanji Yamaguchi, Hideaki Fukushima, Yoshihiro Kamada, Yoshio Sumida, Shinichi Aishima, Yoshito Itoh, Takeshi Okanoue, Atsushi Nakajima, Hirokazu Takahashi

Hepatology Research 53 ( 6 ) 489 - 496 2023.6 （ ISSN:1386-6346 eISSN:1872-034X ）

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Aim: Agile 3+ and Agile 4 scores, based on liver stiffness measurement (LSM) by transient elastography and clinical parameters, were recently reported to be effective in identifying advanced fibrosis and cirrhosis in nonalcoholic fatty liver disease (NAFLD). This study aimed to validate the utility of these scores in Japanese patients with NAFLD. Methods: Six hundred forty-one patients with biopsy-proven NAFLD were analyzed. The severity of liver fibrosis was pathologically evaluated by one expert pathologist. The LSM, age, sex, diabetes status, platelet count, and aspartate aminotransferase and alanine aminotransferase levels were used to calculate Agile 3+ scores, and the parameters above excluding age were used for Agile 4 scores. The diagnostic performance of the two scores was evaluated using receiver operating characteristic (ROC) curve analysis. Sensitivity, specificity, and predictive values of the original low cut-off (for rule-out) value and high cut-off (for rule-in) value were tested. Results: For diagnosis of fibrosis stage ≥3, the area under the ROC (AUROC) was 0.886, and the sensitivity of the low cut-off value and the specificity of the high cut-off value were 95.3% and 73.4%, respectively. For diagnosis of fibrosis stage 4, AUROC, the sensitivity of the low cut-off value, and the specificity of the high cut-off value were 0.930, 100%, and 86.5%, respectively. Both scores had higher diagnostic performance than the FIB-4 index and the enhanced liver fibrosis score. Conclusions: Agile 3+ and Agile 4 are reliable noninvasive tests to identify advanced fibrosis and cirrhosis in Japanese NAFLD patients with adequate diagnostic performance.

DOI： 10.1111/hepr.13890

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非アルコール性脂肪性肝疾患の日本人患者におけるAgileスコアを用いた進行性線維化および肝硬変特定の有用性に関する検証(Validation of the utility of Agile scores to identify advanced fibrosis and cirrhosis in Japanese patients with nonalcoholic fatty liver disease)

Oeda Satoshi, Seko Yuya, Hayashi Hideki, Arai Taeang, Iwaki Michihiro, Yoneda Masato, Shima Toshihide, Notsumata Kazuo, Ikegami Tadashi, Fujii Hideki, Toyoda Hidenori, Miura Kouichi, Morishita Asahiro, Kawata Kazuhito, Tomita Kengo, Kawanaka Miwa, Isoda Hiroshi, Yamaguchi Kanji, Fukushima Hideaki, Kamada Yoshihiro, Sumida Yoshio, Aishima Shinichi, Itoh Yoshito, Okanoue Takeshi, Nakajima Atsushi, Takahashi Hirokazu

Hepatology Research 53 ( 6 ) 489 - 496 2023.6 （ ISSN:1386-6346 ）

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非アルコール性脂肪性肝疾患(NAFLD)の日本人患者において、進行性線維化および肝硬変の特定にAgile 3+とAgile 4スコアが有用かどうか検討した。2012～2021年に肝生検と肝硬度測定を受け、NAFLDが証明された患者を後ろ向きに調べた。ROC曲線解析でAgile 3+とAgile 4スコアの診断能を評価し、除外診断(rule-out)の低カットオフ値、診断(rule-in)の高カットオフ値の感度、特異度、予測値を算出した。診断能を既存のFIB-4 indexとELF(Enhanced Liver Fibrosis)スコアと比較した。患者641例(年齢17～86歳、女性56.2%)を解析した。Agile 3+による線維化ステージ3以上の診断のROC曲線下面積(AUROC)は0.886、低カットオフ値の感度は95.3%、高カットオフ値の特異度は73.4%であった。Agile 4による線維化ステージ4の診断のAUROC、低カットオフ値の感度、高カットオフ値の特異度はそれぞれ0.930、100%、86.5%であった。両スコアは、FIB-4 indexおよびELFスコアより診断能が高かった。以上より、NAFLD日本人患者においてAgile 3+とAgile 4スコアは進行性線維化および肝硬変の診断に用いることが可能と考えられた。
Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease

Hirokazu Takahashi, Miwa Kawanaka, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Nutrients 15 ( 9 ) 2023.5 （ eISSN:2072-6643 ）

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The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver transplantation (OLT), liver-related death, and liver-related events (hepatocellular carcinoma [HCC], decompensated cirrhosis, and gastroesophageal varices/bleeding). 1383 Japanese patients with biopsy-confirmed NAFLD were analyzed. They were divided into 3 groups based on serum albumin: high (>4.0 g/dL), intermediate (3.5–4.0 g/dL), and low (<3.5 g/dL). Unadjusted hazard ratio [HR] of the intermediate albumin group, compared with the high albumin group, were 3.6 for death or OLT, 11.2 for liver-related death, 4.6 for HCC, 8.2 for decompensated cirrhosis, and 6.2 for gastroesophageal varices (all risks were statistically significant). After adjusting confounding factors, albumin remained significantly associated with death or OLT (intermediate vs. high albumin group: HR 3.06, 95% confidence interval [CI] 1.59–5.91, p < 0.001; low vs. high albumin group: HR 22.9, 95% CI 8.21–63.9, p < 0.001). Among biopsy-confirmed NAFLD patients, those with intermediate or low serum albumin had a significantly higher risk of death or OLT than those with high serum albumin.

DOI： 10.3390/nu15092014

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Multicenter, retrospective, cohort study shows platelet counts predict hepatocellular carcinoma development in patients with nonalcoholic fatty liver disease

Hideki Fujii, Makoto Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Norifumi Kawada, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Hepatology Research 53 ( 5 ) 391 - 400 2023.5 （ ISSN:1386-6346 eISSN:1872-034X ）

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Aim: Impacts of platelet counts at the time of liver biopsy on hepatocellular carcinoma (HCC) development in patients with nonalcoholic fatty liver disease (NAFLD) remain unknown. The aim of this study was to investigate the prognostic value of platelet counts in patients with biopsy-confirmed NAFLD using data from a multicenter study. Methods: One thousand three hundred ninety-eight patients were included in this subanalysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) in Asia study. Liver biopsy specimens were pathologically diagnosed, and histologically scored using the NASH Clinical Research Network system. Demographic, clinical, laboratory, and pathological data were collected. Results: During a median follow-up period of 4.6 years (range, 0.3–21.6 years), which corresponds to 8874 person-years, 37 patients developed HCC. Using a cut-off baseline platelet count of 192 × 109/L, the lower platelet group had a higher HCC rate than the higher platelet group (6.7% vs. 0.4%; p < 0.001). This cut-off value significantly stratified the event-free rate for HCC. Lower platelet counts were associated with an increased risk of HCC development. Relative to patients with platelet counts of 192 × 109/L, patients with platelet counts of 100 × 109/L had an unadjusted hazard ratio (HR) for HCC development of 7.37 (95% confidence interval [CI], 3.81–14.2) and an adjusted HR of 11.2 (95% CI, 3.81–32.7; p < 0.001), adjusting for age, sex, NASH, and diabetes. Conclusions: Baseline platelet counts of 192 × 109/L and lower are associated with a higher risk of developing HCC in patients with biopsy-confirmed NAFLD and require active surveillance.

DOI： 10.1111/hepr.13884

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多施設共同後ろ向きコホート研究により、血小板数が非アルコール性脂肪性肝疾患患者の肝細胞癌発生を予測することが示された(Multicenter, retrospective, cohort study shows platelet counts predict hepatocellular carcinoma development in patients with nonalcoholic fatty liver disease)

Fujii Hideki, Fujii Makoto, Iwaki Michihiro, Hayashi Hideki, Toyoda Hidenori, Oeda Satoshi, Hyogo Hideyuki, Kawanaka Miwa, Morishita Asahiro, Munekage Kensuke, Kawata Kazuhito, Tsutsumi Tsubasa, Sawada Koji, Maeshiro Tatsuji, Tobita Hiroshi, Yoshida Yuichi, Naito Masafumi, Araki Asuka, Arakaki Shingo, Kawaguchi Takumi, Noritake Hidenao, Ono Masafumi, Masaki Tsutomu, Yasuda Satoshi, Tomita Eiichi, Yoneda Masato, Kawada Norifumi, Tokushige Akihiro, Kamada Yoshihiro, Takahashi Hirokazu, Ueda Shinichiro, Aishima Shinichi, Sumida Yoshio, Nakajima Atsushi, Okanoue Takeshi, Japan Study Group of Nonalcoholic Fatty Liver Disease(JSG-NAFLD)

Hepatology Research 53 ( 5 ) 391 - 400 2023.5 （ ISSN:1386-6346 ）

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多施設共同コホート研究であるCLIONE(Clinical Outcome Nonalcoholic Fatty Liver Disease)研究のサブ解析を実施し、非アルコール性脂肪性肝疾患(NAFLD)患者における血小板数の予後予測能について検討した。NAFLD患者1398例(男性599例、平均54.5±14.2歳)を解析対象とした。評価項目は人口統計学的特徴、各種臨床所見(糖尿病、高血圧、脂質異常症などの有無)、各種検査データ(血小板数など)、病理学的データなどとした。その結果、追跡期間中央値4.6年、追跡期間は8874人・年に37例が肝細胞癌を発症していた。また、ベースラインの血小板数に基づき、血小板低値群495例、血小板高値群903例に分けて検討した。その結果、血小板低値群では血小板高値群と比較して、肝細胞癌発症率が高かった(6.7%対0.4%、p<0.001)。Kaplan-Meier曲線解析の結果、カットオフ値192×10^9/Lは肝細胞癌無イベント率を有意に層別化していた。血小板数低下と肝細胞癌発症リスク上昇には関連が認められた。血小板数192×10^9/Lと比較した場合の血小板数100×10^9/Lの交絡因子調整前ハザード比は7.37(95%CI 3.81～14.2、p<0.001)、調整後ハザード比は11.2(95%CI 3.81～32.7、p<0.001)であった。以上から、血小板数が肝細胞癌の発症に及ぼす潜在的な影響が示され、血小板数の少ない患者に対する積極的なサーベイランスを行う必要性が示唆された。
低異型粘液性上皮を伴う胆嚢壁内嚢胞性病変の1例

杉生久実, 村田年弘, 川真田修, 今田孝子, 眞壁幹夫, 相島慎一

日本臨床外科学会雑誌 84 ( 5 ) 820 - 824 2023.5 （ ISSN:1345-2843 ）

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症例は71歳,男性.以前より胆石の指摘があり,術前の腹部MRIで胆石症と胆嚢腺筋症の術前診断となり,腹腔鏡下胆嚢摘出術を施行.切除標本で25mm大の粘膜下腫瘤様の隆起を認め,割面で多房性の嚢胞性病変と判明.病理組織学的検査で,胆嚢腺筋症と胆嚢壁内に限局した粘液性上皮による多房性の嚢胞性病変を認めた.嚢胞上皮はMUC5ACとMCU6が部分的に陽性で胃型粘液の特徴を示し,一部でlow gradeの異型上皮を認めた.自験例は胆嚢壁内に限局した壁内発育型の嚢胞性病変であり,形態的にintramural multicystic mucinous neoplasm with low-grade intraepithelial neoplasiaと表現した.まれな病理像であったため報告する.(著者抄録)
Correction to: Heparin/Growth Factors-Immobilized Aligned Electrospun Nanofibers Promote Nerve Regeneration in Polycaprolactone/Gelatin-Based Nerve Guidance Conduits (Advanced Fiber Materials, (2023), 5, 2, (554-573), 10.1007/s42765-022-00244-6)

Yasuhiro Ikegami, Muhammad Shafiq, Shinichi Aishima, Hiroyuki Ijima

Advanced Fiber Materials 5 ( 2 ) 696 - 696 2023.4 （ ISSN:2524-7921 eISSN:2524-793X ）

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In this article the affiliation details for Author Muhammad Shafiq were incorrectly given. They should have been assigned as shown below. The original article has been corrected. Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-Ku, Fukuoka, 819–0395, Japan Department of Biotechnology, Faculty of Science and Technology, University of Central Punjab (UCP), Lahore, 54,000, Pakistan.

DOI： 10.1007/s42765-023-00261-z

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Heparin/Growth Factors-Immobilized Aligned Electrospun Nanofibers Promote Nerve Regeneration in Polycaprolactone/Gelatin-Based Nerve Guidance Conduits

Yasuhiro Ikegami, Muhammad Shafiq, Shinichi Aishima, Hiroyuki Ijima

Advanced Fiber Materials 5 ( 2 ) 554 - 573 2023.4 （ ISSN:2524-7921 eISSN:2524-793X ）

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Injuries to the nervous system account for the widespread morbidity, mortality, and discomfort worldwide. Artificial nerve guidance conduits (NGCs) offer a promising platform for nerve reconstruction, however, they require extracellular matrix (ECM)-like features to better mimic the in vivo microenvironment. Consequently, this research was aimed to fabricate heparin/growth factors (GFs)-immobilized artificial NGCs. Heparin was covalently immobilized onto aligned electrospun polycaprolactone/gelatin (PCL/Gel) nanofibers. Thereafter, basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) were preferentially immobilized on heparinized nanofibers; the immobilization efficiency of GFs was found to be 50% with respect to (w.r.t.) their initial loaded amounts. The in vivo implantation of NGCs in a sciatic nerve defect model revealed the successful retention (~ 10% w.r.t the initial loaded amount) and bioactivity of NGF for up to 5 days. The permeability of bovine serum albumin (BSA) from nanofibrous membranes was further assessed and found to be comparable with the commercialized cellulose acetate membranes. The bioactivity of NGCs was assessed in a sciatic nerve defect model in rats for short-term (1 week) and long-term (1-month). The NGCs displayed good structural stability and biocompatibility in vivo. The in vivo evaluation revealed the accumulation of host cells into the transplanted NGCs. Taken together; these heparin/GFs-immobilized artificial NGCs may have broad implications for nerve regeneration and related tissue engineering disciplines. Graphical Abstract: [Figure not available: see fulltext.].

DOI： 10.1007/s42765-022-00244-6

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Diagnostic accuracy of enhanced liver fibrosis test for nonalcoholic steatohepatitis-related fibrosis: Multicenter study

Yuya Seko, Hirokazu Takahashi, Hidenori Toyoda, Hideki Hayashi, Kanji Yamaguchi, Michihiro Iwaki, Masato Yoneda, Taeang Arai, Toshihide Shima, Hideki Fujii, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Yuichi Yoshida, Tadashi Ikegami, Kazuo Notsumata, Satoshi Oeda, Yoshihiro Kamada, Yoshio Sumida, Hideaki Fukushima, Eiji Miyoshi, Shinichi Aishima, Takeshi Okanoue, Atsushi Nakajima, Yoshito Itoh

Hepatology Research 53 ( 4 ) 312 - 321 2023.4 （ ISSN:1386-6346 eISSN:1872-034X ）

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Aim: The enhanced liver fibrosis (ELF) test is a noninvasive method for diagnosing hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). This multicenter cohort study aimed to evaluate the accuracy of the ELF test and compare it with other noninvasive tests in Japan. Methods: We analyzed 371 Japanese patients with biopsy-proven NAFLD. We constructed area under the receiver operator characteristic curves (AUROC) to determine the diagnostic accuracies of the ELF test, the Mac-2-binding protein glycosylation isomer (M2BPGi), the Fibrosis-4 (FIB-4) index, and combinations of these indices. Results: In patients with F0/F1/F2/F3/F4 fibrosis, the median values of the ELF test were 8.98/9.56/10.39/10.92/11.41, respectively. The AUROCs of the ELF test for patients with F0 versus F1–4, F0–1 versus F2–4, F0–2 versus F3–4, and F0–3 versus F4 fibrosis were 0.825/0.817/0.802/0.812, respectively. The AUROCs of the ELF test were greater than those of the FIB-4 index and M2BPGi at each fibrosis stage. Respective low and high cut-off values yielded sensitivities and specificities for predicting advanced fibrosis (≥F3) of 91.1% and 50.8%, and 38.5% and 92.8%, respectively. For F3 or F4 fibrosis, the combined values from the ELF test and FIB-4 index showed a sensitivity of 98.5%, and the combined values from the ELF test and M2BPGi assay showed a specificity of 97.5%. Conclusions: In Japan, the ELF test predicts NAFLD-related fibrosis from its early stages. The diagnostic ability of the ELF test was not inferior to that of other indices, and the combined values of ELF plus other indices were more accurate.

DOI： 10.1111/hepr.13871

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非アルコール性脂肪肝炎関連線維症に対するEnhanced Liver fibrosis検査の診断精度　多施設共同研究(Diagnostic accuracy of enhanced liver fibrosis test for nonalcoholic steatohepatitis-related fibrosis: Multicenter study)

Seko Yuya, Takahashi Hirokazu, Toyoda Hidenori, Hayashi Hideki, Yamaguchi Kanji, Iwaki Michihiro, Yoneda Masato, Arai Taeang, Shima Toshihide, Fujii Hideki, Morishita Asahiro, Kawata Kazuhito, Tomita Kengo, Kawanaka Miwa, Yoshida Yuichi, Ikegami Tadashi, Notsumata Kazuo, Oeda Satoshi, Kamada Yoshihiro, Sumida Yoshio, Fukushima Hideaki, Miyoshi Eiji, Aishima Shinichi, Okanoue Takeshi, Nakajima Atsushi, Itoh Yoshito, Japan Study Group of Nonalcoholic Fatty Liver Disease(JSG-NAFLD)

Hepatology Research 53 ( 4 ) 312 - 321 2023.4 （ ISSN:1386-6346 ）

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1990年1月から2020年2月までに6施設で登録された日本人非アルコール性脂肪性肝疾患(NAFLD)患者を対象に、Enhanced Liver fibrosis(ELF)検査の診断能を推定し、他の非侵襲的検査と比較した。NAFLD患者371例(年齢17～85歳)を対象とした。ROC曲線下面積(AUC)を作成し、ELF検査、Mac-2結合蛋白糖鎖修飾異性体(M2BPGi)、Fibrosis-4(FIB-4)指標、それらの指標の組み合わせの診断精度を検討した。その結果、F0/F1/F2/F3/F4線維症患者では、ELF検査の中央値はそれぞれ8.98/9.56/10.39/10.92/11.41であった。F0対F1-4、F0-1対F2-4、F0-2対F3-4、F0-3対F4線維症の患者に対するELF検査のAUCは、それぞれ0.825/0.817/0.802/0.812であった。低いカットオフ値9.80と高いカットオフ値11.30では、進行線維症(≧F3)の予測に対する感度と特異度は、それぞれ91.1%と50.8%、38.5%と92.8%であった。F3またはF4線維症では、ELF検査とFIB-4指標を組み合わせた値は98.5%の感度を示し、ELF検査とM2BPGiアッセイを組み合わせた値は97.5%の特異度を示した。以上より、ELF検査の診断能力は他の指標より劣っておらず、ELFと他の指標の組み合わせはより正確であった。
Combined effect of SDF-1 peptide and angiogenic cues in co-axial PLGA/gelatin fibers for cutaneous wound healing in diabetic rats

Muhammad Shafiq, Zhengchao Yuan, Muhammad Rafique, Shinichi Aishima, Hou Jing, Liang Yuqing, Hiroyuki Ijima, Shichao Jiang, Xiumei Mo

Colloids and Surfaces B: Biointerfaces 223 113140 2023.3 （ ISSN:0927-7765 eISSN:1873-4367 ）

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Skin regeneration is hindered by poor vascularization, prolonged inflammation, and excessive scar tissue formation, which necessitate newer strategies to simultaneously induce blood vessel regeneration, resolve inflammation, and induce host cell recruitment. Concurrent deployment of multiple biological cues to realize synergistic reparative effects may be an enticing avenue for wound healing. Herein, we simultaneously deployed SDF (stromal cell-derived factor)− 1α, VEGF (vascular endothelial growth factor)-binding peptide (BP), and GLP (glucagon like peptide)− 1 analog, liraglutide (LG) in core/shell poly(L-lactide-co-glycolide)/gelatin fibers to harness their synergistic effects for skin repair in healthy as well as diabetic wound models in rats. Microscopic techniques, such as SEM and TEM revealed fibrous and core/shell type morphology of membranes. Boyden chamber assay and scratch-wound assay displayed significant migration of HUVECs (human umbilical vein endothelial cells) in SDF-1α containing fibers. Subcutaneous implantation of membranes revealed higher cellular infiltration in SDF-1α loaded fibers, especially, those which were co-loaded with LG or BP. Implantation of membranes in an excisional wound model in healthy rats further showed significant and rapid wound closure in dual cues loaded groups as compared to control or single cue loaded groups. Similarly, the implantation of dressings in type 2 diabetes rat model revealed fast healing, skin appendages regeneration, and blood vessel regeneration in dual cues loaded fibers (SDF-1α/LG, SDF-1α/BP). Taken together, core/shell type fibers containing bioactive peptides significantly promoted wound repair in healthy as well as diabetic wound models in rats.

DOI： 10.1016/j.colsurfb.2023.113140

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Prevention and Repair of Ultraviolet B-Induced Skin Damage in Hairless Mice via Transdermal Delivery of Growth Factors Immobilized in a Gel-in-Oil Nanoemulsion

Yi Zhang, Yuuta Inoue, Jannatul Fardous, Ryota Doi, Takahiro Ijima, Toshioh Fujibuchi, Yo Ichi Yamashita, Shinichi Aishima, Hiroyuki Ijima

ACS Omega 8 ( 10 ) 9239 - 9249 2023.3 （ ISSN:2470-1343 eISSN:2470-1343 ）

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Ultraviolet (UV) radiation from the sun or artificial sources is one of the primary causes of skin damage, including sunburns, tanning, erythema, and skin cancer. Among the three different types of UV rays, UVB rays have a medium wavelength that can penetrate the epidermal layer of the skin, resulting in sunburn, suntan, blistering, and melanoma in case of chronic exposure. This study aimed to evaluate the preventive and therapeutic effects of a gel-in-oil nanogel dispersion (G/O-NGD) as a transdermal delivery biomolecular carrier for skin damage caused by UVB light. The efficacy of this carrier against UVB-induced skin damage was investigated in vivo by delivering different growth factors (GFs) encapsulated in a G/O-NGD. Artificial UVB light was used to induce skin damage in nude mice, followed by the transdermal application of five GF [vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), transforming growth factor (TGF)-1, and insulin-like growth factor (IGF)-α]-immobilized G/O-NGD. Among these GFs, VEGF and bFGF promoted angiogenesis, while EGF, TGF-1, and IGF-α promoted the repair and regeneration of damaged cells. The results showed that G/O-NGD was superior to heparin-immobilized G/O-NGD in reducing UVB-induced skin damage, such as erythema, epidermal water reduction, inflammation, and dermis thickening. In addition, G/O-NGD could prevent and treat abnormal follicle proliferation caused by UVB rays and exhibited potential to repair lipid glands. Overall, our results demonstrate the potential of G/O-NGDs for the treatment of UVB-induced skin damage.

DOI： 10.1021/acsomega.2c07343

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Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-based Cohort Study

Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Norifumi Kawada, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Clinical Gastroenterology and Hepatology 21 ( 2 ) 370 - 379 2023.2 （ ISSN:1542-3565 eISSN:1542-7714 ）

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Background & Aims: There are no detailed reports of clinical outcomes in Asian patients with nonalcoholic fatty liver disease (NAFLD) who undergo liver biopsy. We aimed to investigate the clinical outcomes of a large cohort of Asian patients with biopsy-proven NAFLD and evaluate the specific effects of nonalcoholic steatohepatitis and fibrosis stage. Methods: This multicenter registry-based retrospective cohort study, called the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) in Asia, included 1398 patients. Results: The median follow-up period was 4.6 years (range, 0.3–21.6 years), representing a total of 8874 person-years of follow-up. During that time, 47 patients died, and 1 patient underwent orthotopic liver transplantation. The leading cause of death was nonhepatic cancer (n = 10). The leading causes of liver-related death were liver failure (n = 9), hepatocellular carcinoma (HCC) (n = 8), and cholangiocellular carcinoma (n = 4). During follow-up, 37 patients developed HCC, 31 developed cardiovascular disease, and 68 developed nonhepatic cancer (mainly breast, stomach, and colon/rectum). Among our cohort of patients with NAFLD, liver-specific mortality was 2.34/1000 person-years (95% confidence interval [CI], 1.52–3.58), overall mortality was 5.34/1000 person-years (95% CI, 4.02–7.08), and HCC incidence was 4.17/1000 person-years (95% CI, 3.02–5.75). Liver fibrosis was independently associated with liver-related events but not overall mortality. Conclusions: Liver-related mortality was the leading cause of mortality in Asian patients with biopsy-confirmed NAFLD. Although fibrosis stage was independently associated with liver-related events, it was not associated with overall mortality after adjusting for confounders, such as histologic features of steatohepatitis.

DOI： 10.1016/j.cgh.2022.01.002

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Time to enhancement of breast lesions and normal breast parenchyma in light of menopausal status and menstrual cycle for ultrafast dynamic contrast-enhanced MRI using compressed sensing

Ken Yamaguchi, Takahiko Nakazono, Ryoko Egashira, Shuichi Fukui, Koichi Baba, Takahiro Hamamoto, Shinichi Aishima, Katsuya Maruyama, Dominik Nickel, Hiroyuki Irie

Magnetic Resonance Imaging 96 102 - 107 2023.2 （ ISSN:0730-725X eISSN:1873-5894 ）

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Purpose: To assess the dependency of the Time to enhancement (TTE) of breast lesions and normal breast parenchyma from menopausal status and menstrual cycle using ultrafast compressed sensing (CS) -accelerated dynamic contrast-enhanced (DCE) MRI. Methods: This institutional review board approved retrospective study included 89 breast cancers, 22 benign lesions and 131 normal breast parenchymal foci. A prototypical ultrafast DCE sequence obtained 30 phases with 2.9 s temporal resolution. Mean and median TTE of all breast cancers, benign lesions and normal breast parenchymal foci were assessed. we also assessed whether there were any differences in TTE regarding the menopausal status and menstrual cycle. Results: The TTE of breast cancer was significantly shorter than that of benign lesions and normal breast parenchymal foci in both the premenopausal status (5.8 vs. 8.7 and 8.7 s, respectively) (p = 0.0028 and < 0.0001, respectively) and postmenopausal status (5.8 vs. 11.6 and 11.6 s, respectively) (p < 0.0001 in both). The TTE of parenchymal foci in the premenopausal status was significantly shorter than that in the postmenopausal status (p = 0.0025). Although the TTE interval between cancer and parenchymal foci in premenopausal status is shorter than that in postmenopausal status, the AUCs in the pre- and postmenopausal status for differentiating breast cancer and parenchymal foci were comparable with using different cutoff TTE values. There were no differences in TTE regarding the menstrual cycle. Conclusions: The TTE derived from ultrafast CS-accelerated DCE MRI was useful to differentiate breast cancer from benign lesions and normal breast parenchymal foci in both pre- and postmenopausal status.

DOI： 10.1016/j.mri.2022.11.006

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Validation of Noninvasive Markers for HCC Risk Stratification in 1389 Patients With Biopsy-proven NAFLD

Hidenori Toyoda, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Norifumi Kawada, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Gastro Hep Advances 2 ( 8 ) 1093 - 1102 2023.1 （ eISSN:2772-5723 ）

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Background and Aims: Nonalcoholic fatty liver diseases (NAFLD) and nonalcoholic steatohepatitis (NASH) can cause hepatocellular carcinoma (HCC). We examined histological features and reported noninvasive markers/models for stratifying the risk of HCC development in patients with biopsy-proven NAFLD or NASH. Methods: A total of 1389 patients who had a histological diagnosis of NAFLD or NASH based on liver biopsy and underwent regular surveillance for HCC were included. The ability to predict HCC development was compared between histological features including liver fibrosis and NAFLD activity score, and noninvasive markers/models including aMAP (age, male, albumin–bilirubin, and platelet) score, FIB-4 (Fibrosis-4) index, and ALBI (albumin-bilirubin) score calculated at the time of biopsy. Results: The C index of aMAP score was 0.887, which was consistent with the original report, comparable to FIB-4 index (0.878), and higher than those of ALBI score (0.789), histological liver fibrosis (0.723), and NAFLD activity score (0.589). The hazard ratios for HCC development in the aMAP intermediate and high-risk groups were 21.0 (95% confidence interval [CI], 3.6–402.0) and 110.3 (95% CI, 16.3–2251.4), respectively, in comparison to the aMAP score low-risk group. Those in the FIB-4 index moderate- and high-fibrosis groups were 10.3 (95% CI, 1.7–199.8) and 93.1 (95% CI, 16.3–1773.8), respectively, in comparison to the FIB-4 index mild-fibrosis group. No patients in the aMAP score low-risk group developed HCC during the study period. Conclusion: For stratifying the risk of HCC development in patients with biopsy-proven NAFLD or NASH, both aMAP score and FIB-4 index showed high discriminative ability as noninvasive markers, which were superior histological features.

DOI： 10.1016/j.gastha.2023.07.018

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ALK rearrangement-associated renal cell carcinoma morphologically mimicking mucinous tubular and spindle cell carcinoma: a case report

Keita Kai, Shohei Tobu, Shinichi Kido, Shuji Mikami, Kengo Takeuchi, Akito Dobashi, Yuki Togashi, Mitsuru Noguchi, Shinichi Aishima

Diagnostic Pathology 17 ( 1 ) 2022.12 （ eISSN:1746-1596 ）

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Background: Anaplastic lymphoma kinase rearrangement-associated renal cell carcinoma (ALK-RCC) is an extremely rare tumor and ALK-RCC that mimics mucinous tubular and spindle cell carcinoma (MTSCC) has been very reported only in one instance. Case presentation: A 42-year-old Japanese woman was admitted to our hospital for the treatment of a left renal tumor measuring 5 cm in maximum dimension. She underwent a laparoscopic left nephrectomy. Histologically, the tumor formed tubular or focally papillary structures with a small amount of spindle-shaped tumor cells against the background of prominent extracellular mucin. Although the tumor cells were negative for immunohistochemistry (IHC) of alpha-methylacyl-CoA racemase (AMACR) and lymph node metastasis was presented (these are atypical findings for MTSCC), we initially diagnosed the tumor as MTSCC based on its morphological characteristics with mucin deposition. However, an additional IHC analysis revealed that the tumor cells were diffusely positive for ALK-IHC. In addition, TPM3 exon 8 – ALK exon 20 fusion gene was detected by RNA sequencing. The tumor was thus correctly diagnosed as ALK rearrangement-associated renal cell carcinoma (ALK-RCC). Conclusions: Since the use of molecular targeted therapy with an ALK inhibitor for ALK-RCC is promising, the correct pathological diagnosis of ALK-RCC is quite important. We strongly recommend that ALK-IHC be routinely performed for renal tumors with negative AMACR staining that mimic MTSCC.

DOI： 10.1186/s13000-022-01238-z

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Silence of resident microglia in GPI anchorless prion disease and activation of microglia in Gerstmann-Sträussler-Scheinker disease and sporadic Creutzfeldt-Jakob disease

Hideko Noguchi, Sachiko Koyama, Kaoru Yagita, Masahiro Shijo, Kosuke Matsuzono, Hideomi Hamasaki, Takaaki Kanemaru, Tsuyoshi Okamoto, Keita Kai, Shinichi Aishima, Koji Abe, Naokazu Sasagasako, Hiroyuki Honda

Journal of neuropathology and experimental neurology 82 ( 1 ) 38 - 48 2022.12 （ ISSN:0022-3069 eISSN:1554-6578 ）

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GPI anchorless prion diseases (GPIALPs) show numerous coarse prion protein (PrP) deposits in the CNS but neuropil spongiform changes are mild and the incidence of dementia is low. Here, we examined differences in resident microglial phenotypes between GPIALP (D178fs25) and the other prion diseases Gerstmann-Sträussler-Scheinker (GSS) disease and sporadic Creutzfeldt-Jakob disease (sCJD) with respect to homeostasis and activation. Immunohistochemistry was performed on 2 GPIALP (D178fs25), 4 GSS (P102L), and 4 sCJD cases. Homeostatic microglia expressing TMEM119 and P2RY12 were preserved in GPIALP compared to GSS and sCJD. Microglia/macrophage activation in GSS and sCJD was associated with the extent of spongiform change. Immunoelectron microscopy revealed TMEM119 and P2RY12 in PrP plaque cores. Activated microglia/macrophages expressing HLA-DR and CD68 were predominant in GSS and sCJD whereas in GPIALP, homeostatic microglia were retained and activated microglia/macrophages were rarely observed. These data suggest that PrP deposition in GPIALP is less toxic and that microglia may be immune-tolerant to PrP deposition. This may be associated with milder tissue damage and a low incidence of dementia. Whereas microglia/macrophage activation is considered to be a reaction to tissue injury, this study shows that the degree of microglia/macrophage activity might influence the extent of tissue damage.

DOI： 10.1093/jnen/nlac098

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Age-dependent effects of diabetes and obesity on liver-related events in non-alcoholic fatty liver disease: Subanalysis of CLIONE in Asia

Yuya Seko, Miwa Kawanaka, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Takeshi Okanoue, Yoshito Itoh, Atsushi Nakajima

Journal of Gastroenterology and Hepatology (Australia) 37 ( 12 ) 2313 - 2320 2022.12 （ ISSN:0815-9319 eISSN:1440-1746 ）

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Background and Aim: Older age, type 2 diabetes mellitus (T2DM), and obesity are known risk factors for liver-related events (LREs). We investigated the impacts of T2DM and obesity on LRE according to age in Japanese patients with non-alcoholic fatty liver disease (NAFLD). Methods: We performed a subanalysis of a retrospective cohort study (CLIONE in Asia), including 1395 patients with biopsy-proven NAFLD. The median follow-up was 4.6 years. Results: The median age was 57 years, and 36.2% had T2DM. The median body mass index (BMI) was 27.4, and 28.5% were severely obese (BMI ≥ 30). During follow-up, 37 patients developed hepatocellular carcinoma (HCC), and 58 patients developed LRE. In patients younger than 65 years, advanced fibrosis (hazard ratio [HR] 7.69, P < 0.001) and T2DM (HR 3.37, P = 0.017) were HCC risk factors, and advanced fibrosis (HR 9.40, P < 0.001) and T2DM (HR 2.51, P = 0.016) were LRE risk factors. In patients 65 years and older, advanced fibrosis (HR 4.24, P = 0.010) and obesity (HR 4.60, P = 0.006) were HCC risk factors, and advanced fibrosis (HR 4.22, P = 0.002) and obesity (HR 4.22, P = 0.002) were LRE risk factors. Conclusion: Type 2 diabetes mellitus and obesity contributed to LRE in younger and older patients, respectively, along with advanced fibrosis. Therefore, controlling T2DM in patients younger than 65 years and controlling weight in patients 65 years and older could prevent LRE. The development of age-dependent screening and management strategies is necessary for patients with NAFLD.

DOI： 10.1111/jgh.16019

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A Case of Massive Dendriform Ossification Showing Diffuse Interstitial Lung Disease in a Patient with a History of Intensive Occupational Dust Exposure

Ryoko Egashira, Koichiro Takahashi, Takahiko Nakazono, Ken Yamaguchi, Naofumi Miyahara, Shinichi Aishima, Kenzo Okamoto, Hiroyuki Irie

Journal of Thoracic Imaging 37 ( 6 ) W106 - W108 2022.11 （ ISSN:0883-5993 eISSN:1536-0237 ）

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Dendriform pulmonary ossification is a subtype of pulmonary ossification that causes ectopic lung tissue ossification.1 Although the exact mechanism is unclear, it is thought to be caused by fibroblasts associated with lung injury.2 The ossification can be idiopathic or secondary and is typically observed as linear or branching structures on computed tomography (CT).3-5 We encountered a case of massive dendriform pulmonary ossification with atypical CT findings in a patient with a history of occupational dust exposure.

DOI： 10.1097/RTI.0000000000000672

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Relationship between cellular morphology and abnormality of SWI/SNF complex subunits in pancreatic undifferentiated carcinoma

Takeo Yamamoto, Kenichi Kohashi, Yutaka Yamada, Jun Kawata, Kukiko Sakihama, Ryota Matsuda, Yutaka Koga, Shinichi Aishima, Masafumi Nakamura, Yoshinao Oda

Journal of Cancer Research and Clinical Oncology 148 ( 11 ) 2945 - 2957 2022.11 （ ISSN:0171-5216 eISSN:1432-1335 ）

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Purpose: Pancreatic undifferentiated carcinoma (UDC) is a rare tumor with a worse prognosis than pancreatic ductal adenocarcinoma (PDAC). Recent study showed that UDC exhibits loss of SMARCB1, which is one of the subunits of the SWI/SNF complex. However, whether there are abnormalities of other SWI/SNF complex subunits in UDC has remained unknown. In this study, we attempted to clarify whether the loss of SWI/SNF complex subunits is related to the pathogenesis of UDC by comparing undifferentiated component (UC) and ductal adenocarcinoma component (DAC). Methods: Genetic analysis of the ten UCs and six DACs was performed. The expression of ARID1A, SMARCA2, SMARCA4, SMARCB1, SMARCC1, and SMARCC2 in formalin-fixed, paraffin-embedded tumor tissues collected by surgical resection from 18 UDC patients was evaluated immunohistochemically. Moreover, two pancreatic cell lines were evaluated for the effects of siARID1A on the mRNA and protein expression of E-cadherin, vimentin, and epithelial-mesenchymal transition (EMT)-related markers by qRT-PCR, western blotting, and immunofluorescence staining. Results: UCs tended to have a higher frequency of mutation in ARID1A, SMARCA4, and SMARCC2 than DACs. Immunohistochemically, UCs revealed reduced/lost expression of ARID1A (72%), SMARCB1 (44%), SMARCC1 (31%), and SMARCC2 (67%). Reduced/lost expression of ARID1A, SMARCB1, and SMARCC2 was significantly more frequently observed in UCs than in DACs. In the pancreatic cell lines, western blotting and qRT-PCR showed that the downregulation of ARID1A increased the expression of vimentin and EMT-related markers. Conclusion: Our results suggest that the abnormality of SWI/SNF complex subunits, especially ARID1A, is one of the factors behind the morphological change of UDC.

DOI： 10.1007/s00432-021-03860-8

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Chronological Changes in the Expression Pattern of Hippocampal Prion Proteins During Disease Progression in Sporadic Creutzfeldt-Jakob Disease MM1 Subtype

Kaoru Yagita, Hideko Noguchi, Sachiko Koyama, Hideomi Hamasaki, Takashi Komori, Shinichi Aishima, Takayuki Kosaka, Mitsuharu Ueda, Yoshihiro Komohara, Akihiro Watanabe, Naokazu Sasagasako, Toshiharu Ninomiya, Yoshinao Oda, Hiroyuki Honda

Journal of Neuropathology and Experimental Neurology 81 ( 11 ) 900 - 909 2022.11 （ ISSN:0022-3069 eISSN:1554-6578 ）

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The differential effects of sporadic Creutzfeldt-Jakob disease (sCJD) on the hippocampus and other neocortical areas are poorly understood. We aimed to reveal the histological patterns of cellular prion protein (PrPC) and abnormal prion protein (PrPSc) in hippocampi of sCJD patients and normal controls (NCs). Our study examined 18 postmortem sCJD patients (MM1, 14 cases; MM1 + 2c, 3 cases; MM1 + 2t, 1 case) and 12 NCs. Immunohistochemistry was conducted using 4 primary antibodies, of which 3 targeted the N-terminus of the prion protein (PrP), and 1 (EP1802Y) targeted the C-terminal domain. PrPC expression was abundant in the hippocampus of NCs, and the distribution of PrPC at CA3/4 was reminiscent of synaptic complexes. In sCJD cases with a disease history of <2 years, antibodies against the N-terminus could not detect synapse-like PrP expression at CA4; however, EP1802Y could characterize the synapse-like expression. PrPSc accumulation and spongiform changes became evident after 2 years of illness, when PrPSc deposits were more noticeably detected by N-terminal-specific antibodies. Our findings highlighted the chronology of histopathological alterations in the CA4 region in sCJD patients.

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Comparison of long-term prognosis between non-obese and obese patients with non-alcoholic fatty liver disease

Michihiro Iwaki, Takaomi Kessoku, Kosuke Tanaka, Anna Ozaki, Yuki Kasai, Atsushi Yamamoto, Kota Takahashi, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, Shunsuke Oyamada, Noritoshi Kobayashi, Shinichi Aishima, Satoru Saito, Atsushi Nakajima, Masato Yoneda

JGH Open 6 ( 10 ) 696 - 703 2022.10 （ eISSN:2397-9070 ）

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Background and Aim: Non-alcoholic fatty liver disease (NAFLD) can progress in non-obese patients as in obese patients. Reports on long-term prognosis in non-obese NAFLD patients are controversial. Therefore, we aimed to examine the long-term prognosis of non-obese patients with NAFLD. Methods: This single-center, retrospective cohort study enrolled biopsy-proven non-obese and obese NAFLD patients between January 2002 and December 2011 and followed them up until 31 March 2021, for death and clinical events (cardiovascular and liver-related events and extrahepatic cancers). Results: Of the 223 NAFLD patients, 58 (26.0%) were non-obese. Compared with obese patients, they had a lower fibrosis stage (0.8 ± 0.80 vs 1.2 ± 0.91; P = 0.004), milder lobular inflammation (0.9 ± 0.7 vs 1.1 ± 0.7; P = 0.02), and significantly lower serum creatinine, total bilirubin, ferritin, and type IV collagen 7S and higher high-density lipoprotein levels. After a median follow-up of 8.9 years, no significant difference was noted in mortality between the two groups (2 [3.4%] non-obese vs 5 [3.0%] obese; log-rank test, P = 0.63). Twelve patients (20.7%) in the non-obese group and 32 (19.4%) in the obese group had clinical events. Although the obese group had a higher incidence of clinical events during the first 10 years of follow-up, the non-obese group had a higher incidence after that (log-rank test, P = 0.67). The non-obese group had a high incidence of malignancy (9 [15.5%] non-obese vs 14 [8.3%] obese; P = 0.13). Conclusion: Non-obese NAFLD does not necessarily have a good prognosis, and some cases have a poor prognosis such as extrahepatic cancers. Further validation is required in the future.

DOI： 10.1002/jgh3.12808

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Multimodality Imaging Approach for a Left Ventricular Aneurysm in a Patient With Myocardial Infarction and Non-Obstructive Coronary Arteries

Goro Yoshioka, Shinjo Sonoda, Shinichi Aishima, Koichi Node

Circulation Journal 86 ( 10 ) 1586 2022.10 （ ISSN:1346-9843 eISSN:1347-4820 ）

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DOI： 10.1253/circj.CJ-21-1080

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Diagnostic Categories and Key Features for Pathological Diagnosis of Endoscopic Ultrasound-Guided Fine Needle Aspiration Biopsy Samples of Pancreatic Lesions: A Consensus Study

Yoshiki Naito, Kenji Notohara, Yuko Omori, Shinichi Aishima, Takao Itoi, Nobuyuki Ohike, Yoshinobu Okabe, Motohiro Kojima, Takuma Tajiri, Mariko Tanaka, Masayuki Tsuneki, Toshio Nakagohri, Tomoko Norose, Kenichi Hirabayashi, Yuki Fukumura, Tomoko Mitsuhashi, Hiroshi Yamaguchi, Noriyoshi Fukushima, Toru Furukawa

Pancreas 51 ( 9 ) 1105 - 1111 2022.10 （ ISSN:0885-3177 eISSN:1536-4828 ）

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Objectives This study aimed to establish a reliable and reproducible categorized diagnostic classification system with identification of key features to achieve accurate pathological diagnosis of endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) samples of pancreatic lesions. Methods Twelve pathologists examined virtual whole-slide images of EUS-FNAB samples obtained from 80 patients according to proposed diagnostic categories and key features for diagnosis. Fleiss κ was used to assess the concordance. Results A hierarchical diagnostic system consisting of the following 6 diagnostic categories was proposed: inadequate, nonneoplasm, indeterminate, ductal carcinoma, nonductal neoplasm, and unclassified neoplasm. Adopting these categories, the average κ value of participants was 0.677 (substantial agreement). Among these categories, ductal carcinoma and nonductal neoplasm showed high κ values of 0.866 and 0.837, respectively, which indicated the almost perfect agreement. Key features identified for diagnosing ductal carcinoma were necrosis in low-power appearance; structural atypia/abnormalities recognized by irregular glandular contours, including cribriform and nonuniform shapes; cellular atypia, including enlarged nuclei, irregular nuclear contours, and foamy gland changes; and haphazard glandular arrangement and stromal desmoplasia. Conclusions The proposed hierarchical diagnostic classification system was proved to be useful for achieving reliable and reproducible diagnosis of EUS-FNAB specimens of pancreatic lesions based on evaluated histological features.

DOI： 10.1097/MPA.0000000000002179

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Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD Patients

Yoshihiro Kamada, Hirokazu Takahashi, Yuji Ogawa, Hideyuki Hyogo, Kyoko Nakamura, Tomomi Yada, Norihiko Asada, Tomomi Bando, Hanako Sawano, Mika Hatanaka, Takako Tosa, Mika Ando, Etsuko Hikita, Kaori Yoshida, Masahiro Koseki, Yoshio Sumida, Kazuhisa Maeda, Makoto Fujii, Shinichi Aishima, Mariko Hayakawa, Atsushi Nakajima

Nutrients 14 ( 17 ) 2022.9 （ eISSN:2072-6643 ）

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Objectives: Weight loss improves the liver pathophysiological status of nonalcoholic fatty liver disease (NAFLD) patients. However, there are few studies that investigate the accurate relationships between nutritional intake and disease progression in NAFLD patients. Methods: A total of 37 biopsy-confirmed NAFLD patients were enrolled in this study. Clinical and nutritional control data of 5074 persons were obtained from the National Institute of Health and Nutrition. Each NAFLD subject recorded dietary intake for seven consecutive days using a dietary questionnaire and photographs of each meal. A dietitian analyzed and quantified the nutritional data in each patient. We further analyzed the nutritional intake of NAFLD patients in three groups according to the following criteria: (1) liver fibrosis degree (advanced, early), (2) gender (male, female), and (3) body mass index (BMI) (high, low). Results: Excesses or deficiencies of multiple nutrients were found in NAFLD patients compared with control subjects. In addition, there were variations in nutritional intake. (1) The intake of vitamins A, B6, and E, pantothenic acid, soluble dietary fiber, and salt was lower in the advanced fibrosis group than in the early fibrosis group. (2) Fat intake was higher in male patients, and dietary fiber intake was lower in both male and female patients compared with control subjects. (3) Saturated fatty acid intake was higher, and copper and vitamin E intakes were lower in patients with high BMI than with low BMI. Conclusions: Our study demonstrates that differences were found in some nutrient intake of NAFLD patients and controls and according to the severity of the conditions (liver fibrosis degree, BMI).

DOI： 10.3390/nu14173453

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Pathological Evaluation of Resected Colorectal Liver Metastases: mFOLFOX6 Plus Bevacizumab versus mFOLFOX6 Plus Cetuximab in the Phase II ATOM Trial

Takao Takahashi, Kazuyuki Ishida, Yasunori Emi, Michiie Sakamoto, Johji Imura, Shinichi Aishima, Kei Muro, Hiroyuki Uetake, Eiji Oki, Yu Katayose, Kazuhiro Yoshida, Michiaki Unno, Ichinosuke Hyodo, Naohiro Tomita, Kenichi Sugihara, Yoshihiko Maehara

Cancers 14 ( 18 ) 2022.9 （ ISSN:2072-6694 eISSN:2072-6694 ）

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We compared the preplanned histopathological responses of resected liver metastases from patients who received modified FOLFOX6 plus bevacizumab or modified FOLFOX6 plus cetuximab for liver-limited colorectal metastases in the ATOM trial. Fibrosis and viable tumor cells in tumor regression grade (TRG), infarct-like necrosis in modified TRG (mTRG), and dangerous halo (DH) were assessed. Fifty-five patients (28 and 27 patients in the bevacizumab and cetuximab arms, respectively) were divided into the low (viable tumor cells ≤ 50%) and high (>50%) TRG or mTRG groups. DH was characterized as absent/rare or focal/diffuse. Compared to the bevacizumab arm, the cetuximab arm was more effective, with respect to low TRG (13 vs. 23 patients) and absent/rare DH (14 vs. 19 patients), respectively. Low mTRG was similarly observed in both arms. Low TRG/mTRG and absent/rare DH showed better relapse-free survival (RFS) than high TRG/mTRG and focal/diffuse DH. In the bevacizumab arm, a significant difference in RFS existed between the low and high TRG groups, while in the cetuximab arm, for TRG, mTRG, and DH, the low and absent/rare groups demonstrated significantly longer RFS than the high and focal/diffuse groups, respectively. TRG could estimate RFS in patients who underwent liver metastasectomy after bevacizumab or cetuximab chemotherapy.

DOI： 10.3390/cancers14184392

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Substantial improvement of histopathological diagnosis by whole-slide image-based remote consultation

Shizu Shinohara, Andrey Bychkov, Jijgee Munkhdelger, Kishio Kuroda, Han Seung Yoon, Shota Fujimura, Kazuhiro Tabata, Bungo Furusato, Daisuke Niino, Shinpei Morimoto, Takashi Yao, Tomoo Itoh, Hajime Aoyama, Naoko Tsuyama, Yoshiki Mikami, Toshitaka Nagao, Tohru Ikeda, Noriyoshi Fukushima, Oi Harada, Takako Kiyokawa, Naoki Yoshimi, Shinichi Aishima, Ichiro Maeda, Ichiro Mori, Koji Yamanegi, Koichi Tsuneyama, Ryohei Katoh, Miki Izumi, Yoshinao Oda, Junya Fukuoka

Virchows Archiv 481 ( 2 ) 295 - 305 2022.8 （ ISSN:0945-6317 eISSN:1432-2307 ）

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Consultation by subspecialty experts is the most common mode of rendering diagnosis in challenging cases in pathological practice. Our study aimed to highlight the diagnostic benefits of whole-slide image (WSI)-based remote consultation. We obtained diagnostically challenging cases from two institutions from the years 2010 and 2013, with histological diagnoses that contained keywords “probable,” “suggestive,” “suspicious,” “inconclusive,” and “uncertain.” A total of 270 cases were selected for remote consultation using WSIs scanned at 40 ×. The consultation process consisted of three rounds: the first and second rounds each with 12 subspecialty experts and the third round with six multi-expertise senior pathologists. The first consultation yielded 44% concordance, and a change in diagnosis occurred in 56% of cases. The most frequent change was from inconclusive to definite diagnosis (30%), followed by minor discordance (14%), and major discordance (12%). Out of the 70 cases which reached the second round, 31 cases showed discrepancy between the two consultants. For these 31 cases, a consensus diagnosis was provided by six multi-expertise senior pathologists. Combining all WSI-based consultation rounds, the original inconclusive diagnosis was changed in 140 (52%) out of 266 cases. Among these cases, 80 cases (30%) upgraded the inconclusive diagnosis to a definite diagnosis, and 60 cases (22%) changed the diagnosis with major or minor discordance, accounting for 28 cases (10%) and 32 cases (12%), respectively. We observed significant improvement in the pathological diagnosis of difficult cases by remote consultation using WSIs, which can further assist in patient healthcare. A post-study survey highlighted various benefits of WSI-based consults.

DOI： 10.1007/s00428-022-03327-2

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前立腺Mucinous adenocarcinomaの一例

藤木和也, 山口健, 福井修一, 中園貴彦, 有働和馬, 野口満, 花島克幸, 相島慎一, 入江裕之

断層映像研究会雑誌 49 ( 1 ) 1 - 6 2022.8 （ ISSN:0914-8663 ）

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症例は70歳代男性。夜間頻尿を主訴に近医を受診。血液検査でPSA値が11.0ng/mlと高値であり前医紹介となった。前医施行の単純MRIで前立腺に多房性嚢胞性腫瘤を認め、STUMP(stromal tumors of uncertain malignant potential)やcystadenoma、cystadenocarcinomaなどが疑われた。更なる精査、加療目的に当院泌尿器科紹介となった。当院施行の造影MRIでは前立腺背側の両葉で移行域、辺縁域にまたがる48×46×55mmの辺縁分葉状の腫瘤を認めた。内部はT2強調像でやや不均一かつ著明な高信号を呈し、隔壁様の構造が多発していた。T1強調像では大部分は低信号を呈し、腫瘤右側には出血や高粘稠度の液貯留を疑う高信号域を認めた。有意な拡散制限は認めず、dynamic studyでは辺縁優位に漸増性の増強効果を認めた。CTでは腫瘤辺縁にわずかに石灰化を認めた。前立腺生検が施行され、10/10本よりmucinous adenocarcinomaの所見が得られた。他部位に原発巣を示唆する所見はなく、前立腺原発のmucinous adenocarcinomaが強く疑われた。前立腺のmucinous adenocarcinomaは全前立腺癌の0.4%と稀な疾患である。腫瘍内に少なくとも25%以上のムチンを含むと定義されている。今回の症例は手術未施行であるが、全身検索および局所の画像所見からは前立腺原発のmucinous adenocarcinomaとして矛盾しない所見であった。画像所見上の鑑別としてSTUMPやcystadenoma、cystadenocarcinomaなどが挙げられたが、所見によってはこれらとの鑑別は困難となる場合も多い。前立腺のmucinous adenocarcinomaの画像所見についての報告は少なく、今回文献的考察を含めて報告する。(著者抄録)
Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study

Yuki Kasai, Takaomi Kessoku, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Takashi Kobayashi, Michihiro Iwaki, Anna Ozaki, Asako Nogami, Yasushi Honda, Yuji Ogawa, Shingo Kato, Kento Imajo, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Haruki Usuda, Koichiro Wada, Miwa Kawanaka, Takumi Kawaguchi, Takuji Torimura, Masayoshi Kage, Hideyuki Hyogo, Hirokazu Takahashi, Yuichiro Eguchi, Shinichi Aishima, Noritoshi Kobayashi, Yoshio Sumida, Akira Honda, Shunsuke Oyamada, Satoru Shinoda, Satoru Saito, Atsushi Nakajima

Clinical and translational gastroenterology 13 ( 7 ) e00503 2022.7 （ eISSN:2155-384X ）

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INTRODUCTION: No reports on both blood and fecal bile acids (BAs) in patients with nonalcoholic fatty liver disease (NAFLD) exist. We simultaneously assessed the serum and fecal BA patterns in healthy participants and those with NAFLD. METHODS: We collected stool samples from 287 participants from 5 hospitals in Japan (healthy control [HC]: n = 88; mild fibrosis: n = 104; and advanced fibrosis group: n = 95). Blood samples were collected and analyzed for serum BAs and 7α-hydroxy-4-cholesten-3-one (C4)-a surrogate marker for BA synthesis ability-from 141 patients. Concentrations of BAs, including cholic acid (CA), deoxycholic acid (DCA), chenodeoxycholic acid, ursodeoxycholic acid, and lithocholic acid (LCA), were measured using liquid chromatography-mass spectrometry. RESULTS: The total fecal BA concentration was significantly higher in the NAFLD group with worsening of fibrosis than in the HC group. Most of the fecal BAs were secondary and unconjugated. In the fecal BA fraction, CA, DCA, chenodeoxycholic acid, ursodeoxycholic acid, and LCA were significantly higher in the NAFLD than in the HC group. The total serum BA concentration was higher in the NAFLD group with worsening of fibrosis than in the HC group. In the serum BA fraction, CA, LCA, and C4 concentrations were significantly higher in the NAFLD than in the HC group. DISCUSSION: Fecal and serum BA and C4 concentrations were high in patients with NAFLD with worsening of fibrosis, suggesting involvement of abnormal BA metabolism in NAFLD with fibrosis progression. Abnormalities in BA metabolism may be a therapeutic target in NAFLD with fibrosis.

DOI： 10.14309/ctg.0000000000000503

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Influence of liver stiffness heterogeneity on staging fibrosis in patients with nonalcoholic fatty liver disease

Nobuyoshi Kawamura, Kento Imajo, Kyle J. Kalutkiewicz, Koki Nagai, Michihiro Iwaki, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Takuma Higurashi, Kunihiro Hosono, Hirokazu Takahashi, Masato Yoneda, Satoru Saito, Shinichi Aishima, Hidenori Toyoda, Hideki Hayashi, Yoshio Sumida, Richard L. Ehman, Atsushi Nakajima

Hepatology 76 ( 1 ) 186 - 195 2022.7 （ ISSN:0270-9139 eISSN:1527-3350 ）

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Background and Aims: Despite that hepatic fibrosis often affects the liver globally, spatial distribution can be heterogeneous. This study aimed to investigate the effect of liver stiffness (LS) heterogeneity on concordance between MR elastography (MRE)-based fibrosis staging and biopsy staging in patients with NAFLD. Approach and Results: We retrospectively evaluated data from 155 NAFLD patients who underwent liver biopsy and 3 Tesla MRE and undertook a retrospective validation study of 169 NAFLD patients at three hepatology centers. Heterogeneity of stiffness was assessed by measuring the range between minimum and maximum MRE-based LS measurement (LSM). Variability of LSM was defined as the stiffness range divided by the maximum stiffness value. The cohort was divided into two groups (homogenous or heterogeneous), according to whether variability was below or above the average for the training cohort. Based on histopathology and receiver operating characteristic (ROC) analysis, optimum LSM thresholds were determined for MRE-based fibrosis staging of stage 4 (4.43, kPa; AUROC, 0.89) and stage ≥3 (3.93, kPa; AUROC, 0.89). In total, 53 had LSM above the threshold for stage 4. Within this group, 30 had a biopsy stage of <4. In 86.7% of these discordant cases, variability of LSM was classified as heterogeneous. In MRE-based LSM stage ≥3, 88.9% of discordant cases were classified as heterogeneous. Results of the validation cohort were similar to those of the training cohort. Conclusions: Discordance between biopsy- and MRE-based fibrosis staging is associated with heterogeneity in LSM, as depicted with MRE.

DOI： 10.1002/hep.32302

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HSPA8 Single-Nucleotide Polymorphism Is Associated with Serum HSC70 Concentration and Carotid Artery Atherosclerosis in Nonalcoholic Fatty Liver Disease

Wenli Zhao, Hitoe Mori, Yuki Tomiga, Kenichi Tanaka, Rasheda Perveen, Keiichiro Mine, Chika Inadomi, Wataru Yoshioka, Yoshihito Kubotsu, Hiroshi Isoda, Takuya Kuwashiro, Satoshi Oeda, Takumi Akiyama, Ye Zhao, Iwata Ozaki, Seiho Nagafuchi, Atsushi Kawaguchi, Shinichi Aishima, Keizo Anzai, Hirokazu Takahashi

Genes 13 ( 7 ) 2022.7 （ eISSN:2073-4425 ）

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There is an association between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis, but the genetic risk of atherosclerosis in NAFLD remains unclear. Here, a single-nucleotide polymorphism (SNP) of the heat shock 70 kDa protein 8 (HSPA8) gene was analyzed in 123 NAFLD patients who had been diagnosed using a liver biopsy, and the NAFLD phenotype including the maximum intima–media thickness (Max-IMT) of the carotid artery was investigated. Patients with the minor allele (A/G or G/G) of rs2236659 showed a lower serum heat shock cognate 71 kDa protein concentration than those with the major A/A allele. Compared with the patients with the major allele, those with the minor allele showed a higher prevalence of hypertension and higher Max-IMT in men. No significant associations between the HSPA8 genotype and hepatic pathological findings were identified. In decision-tree analysis, age, sex, liver fibrosis, and HSPA8 genotype were individually associated with severe carotid artery atherosclerosis (Max-IMT ≥ 1.5 mm). Noncirrhotic men aged ≥ 65 years were most significantly affected by the minor allele of HSPA8. To predict the risk of atherosclerosis and cardiovascular disease, HSPA8 SNP genotyping might be useful, particularly for older male NAFLD patients.

DOI： 10.3390/genes13071265

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Efficacy of a newly developed bioabsorbable pancreatic clip for distal pancreatectomy in swine

Yo ichi Yamashita, Takanobu Yamao, Yosuke Nakao, Tatsunori Miyata, Yasuhiro Ikegami, Soichiro Yamane, Taiga Ito, Taku Furukawa, Jaeyong Cho, Fanqi Wu, Yasumitsu Fujie, Mitsuru Arima, Shinichi Aishima, Hiroyuki Ijima, Hideo Baba

Surgery Today 52 ( 7 ) 1109 - 1114 2022.7 （ ISSN:0941-1291 eISSN:1436-2813 ）

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Purpose: At present, ≥ 20% of patients experience clinically relevant postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). Methods: We developed a new bioabsorbable pancreatic clip (BioPaC) made of polycaprolactone that does not crush the pancreatic parenchyma during occlusion of the pancreatic stump. We confirmed the efficacy of this BioPac in a porcine DP model and compared it to a linear stapling device (Reinforce®). Results: Pigs were killed at 1 month after DP. In the BioPaC group, all swine (n = 3) survived well without POPF. In the Reinforce® group (n = 2), one pig died early at postoperative day 7 with Grade C POPF (amylase 43 700 U/l), and the other survived until 1 month at scarification with biochemical leakage of POPF (amylase 3 725 U/l). Pathologically, the main pancreatic duct and pancreatic parenchyma were well closed by BioPaC. Conclusion: The newly developed BioPaC is effective in a porcine DP model.

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ブタの膵尾部切除に用いられる新規生体吸収性膵臓クリップの有効性(Efficacy of a newly developed bioabsorbable pancreatic clip for distal pancreatectomy in swine)

Yamashita Yo-ichi, Yamao Takanobu, Nakao Yosuke, Miyata Tatsunori, Ikegami Yasuhiro, Yamane Soichiro, Ito Taiga, Furukawa Taku, Cho Jaeyong, Wu Fanqi, Fujie Yasumitsu, Arima Mitsuru, Aishima Shinichi, Ijima Hiroyuki, Baba Hideo

Surgery Today 52 ( 7 ) 1109 - 1114 2022.7 （ ISSN:0941-1291 ）

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膵尾部切除に際して膵断端閉塞中に膵実質を破断させないようなポリカプロラクトン製の新規生体吸収性膵臓クリップ(BioPaC)を作製し、その有効性を検討した。体重25～30kgの健常ブタを用いて実験を行い、手術では膵尾部を脾静脈と後腹膜から切離した後、脾膵葉の最も厚みのある部分を、BioPaCを用いて閉鎖した。対照にはReinforceを用いてBioPaCと同様の処理を施した。BioPaCは長さ59mm、高さ6mm、厚み5mm、クランプ時の幅16mm、クランプ時のギャップ4mmという構造であった。Reinforceを使用したブタ2匹のうち1匹は術後7日目に死亡し、グレードCの術後膵液漏(POPF)と診断された。もう1匹は術後30日まで生存したが、膵断端周囲に著明な腹腔内癒着が観察された。BioPaCを用いた3匹の術後経過は良好で、POPFの発症は認められなかった。病理学的所見ではBioPaCによって主膵管と膵実質の閉鎖が得られていた。ブタ膵尾部切除モデルにおいてBioPaCは有効であることが示された。
嚢胞内容液中に異型を伴う反応性中皮細胞が出現し、良悪性判定が困難であった巨大肝嚢胞の1例

北村捷, 甲斐敬太, 田中智和, 井手貴雄, 上瀧さやか, 能城浩和, 末岡榮三朗, 相島慎一

日本臨床細胞学会九州連合会雑誌 53 73 - 77 2022.7 （ ISSN:0912-6600 ）

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背景反応性中皮細胞は時に強い核異型を呈し、しばしば良悪性の鑑別が問題となる。今回、腹腔鏡下肝嚢胞開窓術中に採取された嚢胞液に反応性中皮細胞が出現し、腺癌との鑑別が問題となった1例を経験した。症例 60歳代女性。肝右葉を占拠する長径17cm大の感染が疑われる肝嚢胞に対して、経皮的穿刺ドレナージが行われた。一旦嚢胞は縮小したが再増大したため、腹腔鏡下肝嚢胞開窓術が施行された。嚢胞開窓後に採取された肝嚢胞内容液が術中迅速細胞診に提出され、核腫大した異型細胞集塊を1ヶ所に認めた。出現数は少ないが腺癌を否定できない異型細胞と報告した。細胞診の結果を受け、肝右葉切除術が施行された。切除検体の組織学的検討において、嚢胞壁を被覆する上皮に異型は認められず、漿膜側に中皮マーカー陽性を示す反応性中皮細胞を多数認めた。迅速細胞診で悪性を疑った異型細胞は反応性中皮細胞であったと結論し、最終的に単純性肝嚢胞と診断した。結論経皮的穿刺ドレナージの経歴から、反応性中皮細胞が出現しうる状況であることを認識していれば、迅速細胞診で正診に至った可能性がある。教訓的な症例であるため、ここに報告する。(著者抄録)
Application of contralateral osteotomy for the en bloc resection of paraspinal and spinal tumours: a report of three cases

Yu Toda, Tadatsugu Morimoto, Yoshihiro Matsumoto, Nokitaka Setsu, Tomohito Yoshihara, Shinichi Aishima, Yoshinao Oda, Yasuharu Nakashima, Masaaki Mawatari

British Journal of Neurosurgery 38 ( 5 ) 1151 - 1157 2022.5 （ ISSN:0268-8697 eISSN:1360-046X ）

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We herein report the effectiveness of contralateral osteotomy of the pedicle and posterolateral elements for en bloc resection (COPPER) of paraspinal and spinal tumours. This surgical method allows for complete resection of the localized tumour in the lateral posterior lesion without removing the entire vertebral body, as in total en bloc spondylectomy. Complete resection of paraspinal and spinal tumours is challenging for spinal surgeons because of anatomical complexities. Although the COPPER method has been introduced as a less invasive surgical procedure for wide resection of spinal tumours, no studies have reported the usefulness of this technique. We identified three patients with paraspinal or spinal tumours who underwent wide resection using the COPPER method and reviewed their clinical, radiological, and pathological outcomes. In all cases, we resected the spinal and paraspinal tumours extending to the anterior column and extravertebral component using the modified COPPER method. All patients underwent en bloc resection with a negative margin. We report three cases of spinal and paraspinal tumours extending to the anterior column and extravertebral component.

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Cytological Comparison between Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Image Analysis Software Using Touch Smear Samples of Surgically Resected Specimens

Sho Kitamura, Keita Kai, Mitsuo Nakamura, Tomokazu Tanaka, Takao Ide, Hirokazu Noshiro, Eisaburo Sueoka, Shinich Aishima

Cancers 14 ( 9 ) 2022.5 （ eISSN:2072-6694 ）

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To investigate useful cytological features for differential diagnosis of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), this study cytologically compared HCC to ICC using image analysis software. Touch smear specimens of surgically resected specimens were obtained from a total of 61 nodules of HCC and 16 of ICC. The results indicated that the major/minor axis ratio of ICC is significantly larger than that of HCC (1.67 ± 0.27 vs. 1.32 ± 0.11, p < 0.0001) in Papanicolaou staining. This result means that the nucleus of HCC is close to round and the nucleus of ICC is close to an oval. This significant difference in the major/minor axis ratio between ICC and HCC was consistently observed by the same analyses using clinical samples of cytology (4 cases of HCC and 13 cases of ICC) such a fine-needle aspiration, brushing and ascites (ICC: 1.45 ± 0.13 vs. HCC: 1.18 ± 0.056, p = 0.004). We also confirmed that nuclear position center-positioned nucleus (p < 0.0001) and granular cytoplasm (p <0.0001) are typical features of HCC tumor cells compared to ICC tumor cells. The research study found a significant difference in the nuclear morphology of HCC (round shape) and ICC (oval shape) in Papanicolaou-stained cytology specimens. This simple and objective finding will be very useful for the differential cytodiagnosis of HCC and ICC.

DOI： 10.3390/cancers14092301

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Direct Comparison of US and MR Elastography for Staging Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Kento Imajo, Yasushi Honda, Takashi Kobayashi, Koki Nagai, Anna Ozaki, Michihiro Iwaki, Takaomi Kessoku, Yuji Ogawa, Hirokazu Takahashi, Yusuke Saigusa, Masato Yoneda, Hiroyuki Kirikoshi, Daisuke Utsunomiya, Shinichi Aishima, Satoru Saito, Atsushi Nakajima

Clinical Gastroenterology and Hepatology 20 ( 4 ) 908 - 917.e11 2022.4 （ ISSN:1542-3565 eISSN:1542-7714 ）

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Background & Aims: As alternatives to the expensive liver biopsy for assessing liver fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD), we directly compared the diagnostic abilities of magnetic resonance elastography (MRE), vibration-controlled transient elastography (VCTE), and two-dimensional shear wave elastography (2D-SWE). Methods: Overall, 231 patients with biopsy-proven NAFLD were included. Intra- and inter-observer reproducibility was analyzed using intraclass correlation coefficient in a sub-group of 70 participants, in whom liver stiffness measurement (LSM) was performed by an elastography expert and an ultrasound expert who was an elastography trainee on the same day. Results: Valid LSMs were obtained for 227, 220, 204, and 201 patients using MRE, VCTE, 2D-SWE, and all three modalities combined, respectively. Although the area under the curve did not differ between the modalities for detecting stage ≥1, ≥2, and ≥3 liver fibrosis, it was higher for MRE than VCTE and 2D-SWE for stage 4. Sex was a significant predictor of discordance between VCTE and liver fibrosis stage. Skin-capsule distance and the ratio of the interquartile range of liver stiffness to the median were significantly associated with discordance between 2D-SWE and liver fibrosis stage. However, no factors were associated with discordance between MRE and liver fibrosis stage. Intra- and inter-observer reproducibility in detecting liver fibrosis was higher for MRE than VCTE and 2D-SWE. Conclusions: MRE, VCTE, and 2D-SWE demonstrated excellent diagnostic accuracy in detecting liver fibrosis in patients with NAFLD. MRE demonstrated the highest diagnostic accuracy for stage 4 detection and intra- and inter-observer reproducibility. UMIN Clinical Trials Registry No. UMIN000031491.

DOI： 10.1016/j.cgh.2020.12.016

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Atrial Structural Remodeling in Patients With Atrial Fibrillation Is a Diffuse Fibrotic Process: Evidence From High-Density Voltage Mapping and Atrial Biopsy

Takanori Yamaguchi, Toyokazu Otsubo, Yuya Takahashi, Kana Nakashima, Akira Fukui, Kei Hirota, Yumi Ishii, Kodai Shinzato, Ryosuke Osako, Mai Tahara, Yuki Kawano, Atsushi Kawaguchi, Shinichi Aishima, Naohiko Takahashi, Koichi Node

Journal of the American Heart Association 11 ( 6 ) 2022.3 （ eISSN:2047-9980 ）

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BACKGROUND: Low-voltage areas (LVAs) in the atria of patients with atrial fibrillation are considered local fibrosis. We hypoth-esized that voltage reduction in the atria is a diffuse process associated with fibrosis and that the presence of LVAs reflects a global voltage reduction. METHODS AND RESULTS: We examined 140 patients with atrial fibrillation and 13 patients with a left accessory pathway (con-trols). High-density bipolar voltage mapping was performed using a grid-mapping catheter during high right atrial pacing. Global left atrial (LA) voltage (VGLA) in the whole LA and regional LA voltage (VRLA) in 6 anatomic regions were evaluated with the mean of the highest voltage at a sampling density of 1 cm2. Patients with atrial fibrillation were categorized into quartiles by VGLA. LVAs were evaluated at voltage cutoffs of 0.1, 0.5, 1.0, and 1.5 mV. Twenty-eight patients with atrial fibrillation also underwent right atrial septum biopsy, and the fibrosis extent was quantified. Voltage at the biopsy site (Vbiopsy) was recorded. VGLA results by category were Q1 (<4.2 mV), Q2 (4.2–5.6 mV), Q3 (5.7–7.0 mV), and Q4 (≥7.1 mV). VRLA at any region was reduced as VGLA decreased. VGLA and VRLA did not differ between Q4 and controls. The presence of LVAs increased as VGLA decreased at any voltage cutoff. Biopsies revealed 11±6% fibrosis, which was inversely correlated with both Vbiopsy and VGLA (r=–0.71 and –0.72, respectively). Vbiopsy was correlated with VGLA (r=0.82). CONCLUSIONS: Voltage reduction in the LA is a diffuse process associated with fibrosis. Presence of LVAs reflects diffuse voltage reduction of the LA.

DOI： 10.1161/JAHA.121.024521

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Concordance of the histological diagnosis of type 1 autoimmune pancreatitis and its distinction from pancreatic ductal adenocarcinoma with endoscopic ultrasound-guided fine needle biopsy specimens: an interobserver agreement study

Kenji Notohara, Terumi Kamisawa, Toru Furukawa, Noriyoshi Fukushima, Takeshi Uehara, Satomi Kasashima, Eisuke Iwasaki, Atsushi Kanno, Atsuhiro Kawashima, Kensuke Kubota, Yasuhiro Kuraishi, Masayo Motoya, Itaru Naitoh, Takayoshi Nishino, Junichi Sakagami, Kyoko Shimizu, Teruko Tomono, Shinichi Aishima, Yuki Fukumura, Kenichi Hirabayashi, Motohiro Kojima, Tomoko Mitsuhashi, Yoshiki Naito, Nobuyuki Ohike, Takuma Tajiri, Hiroshi Yamaguchi, Hideyo Fujiwara, Emi Ibuki, Shota Kobayashi, Masashi Miyaoka, Mamiko Nagase, Junko Nakashima, Masamichi Nakayama, Shinsuke Oda, Daiki Taniyama, Sho Tsuyama, Syunsuke Watanabe, Tsukasa Ikeura, Shigeyuki Kawa, Kazuichi Okazaki

Virchows Archiv 480 ( 3 ) 565 - 575 2022.3 （ ISSN:0945-6317 eISSN:1432-2307 ）

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The histological diagnosis of type 1 autoimmune pancreatitis (AIP) based on the findings obtained by an endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) is feasible, but the diagnostic consistency of this method has not been confirmed. We determined the interobserver agreement among 20 pathologists regarding the diagnosis of type 1 AIP, including the distinction from pancreatic ductal adenocarcinoma (PDAC) using large tissue samples obtained by EUS-FNB. After guidance for diagnosing AIP with biopsy tissues was provided, a round 2 was performed. The median sensitivity and specificity for diagnosing PDAC vs. non-neoplastic diseases were 95.2% and 100%, respectively. In groups of specialists (n = 7) and the generalists (n = 13), Fleiss’ к-values increased from 0.886 to 0.958 and from 0.750 to 0.816 in round 2. The concordance was fair or moderate for obliterative phlebitis and storiform fibrosis but slight for ductal lesion of type 1 AIP. Discordant results were due to ambiguous findings and biopsy tissue limitations. Among the specialists, the ratio of cases with perfect agreement regarding the presence of storiform fibrosis increased in round 2, but agreement regarding obliterative phlebitis or ductal lesions was not improved. Although the histological definite diagnosis of type 1 AIP was achieved by most observers in > 60% of the cases, the confidence levels varied. Because some ambiguities exist, the histological diagnostic levels based on the diagnostic criteria of type 1 AIP should not be taken for granted. Guidance is effective for improving accurate PDAC diagnoses (notably by recognizing acinar-ductal metaplasia) and for evaluating storiform fibrosis.

DOI： 10.1007/s00428-021-03236-w

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Ipragliflozin Improves the Hepatic Outcomes of Patients With Diabetes with NAFLD

Hirokazu Takahashi, Takaomi Kessoku, Miwa Kawanaka, Michihiro Nonaka, Hideyuki Hyogo, Hideki Fujii, Tomoaki Nakajima, Kento Imajo, Kenichi Tanaka, Yoshihito Kubotsu, Hiroshi Isoda, Satoshi Oeda, Osamu Kurai, Masato Yoneda, Masafumi Ono, Yoichiro Kitajima, Ryo Tajiri, Ayako Takamori, Atsushi Kawaguchi, Shinichi Aishima, Masayoshi Kage, Atsushi Nakajima, Yuichiro Eguchi, Keizo Anzai

Hepatology Communications 6 ( 1 ) 120 - 132 2022.1 （ eISSN:2471-254X ）

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Sodium glucose cotransporter-2 inhibitors (SGLT2is) are now widely used to treat diabetes, but their effects on nonalcoholic fatty liver disease (NAFLD) remain to be determined. We aimed to evaluate the effects of SGLT2is on the pathogenesis of NAFLD. A multicenter, randomized, controlled trial was conducted in patients with type 2 diabetes with NAFLD. The changes in glycemic control, obesity, and liver pathology were compared between participants taking ipragliflozin (50 mg/day for 72 weeks; IPR group) and participants being managed without SGLT2is, pioglitazone, glucagon-like peptide-1 analogs, or insulin (CTR group). In the IPR group (n = 25), there were significant decreases in hemoglobin A1c (HbA1c) and body mass index (BMI) during the study (HbA1c, −0.41%, P < 0.01; BMI, −1.06 kg/m2, P < 0.01), whereas these did not change in the CTR group (n = 26). Liver pathology was evaluated in 21/25 participants in the IPR/CTR groups, and hepatic fibrosis was found in 17 (81%) and 18 (72%) participants in the IPR and CTR groups at baseline. This was ameliorated in 70.6% (12 of 17) of participants in the IPR group and 22.2 % (4 of 18) of those in the CTR group (P < 0.01). Nonalcoholic steatohepatitis (NASH) resolved in 66.7% of IPR-treated participants and 27.3% of CTR participants. None of the participants in the IPR group developed NASH, whereas 33.3% of the CTR group developed NASH. Conclusion: Long-term ipragliflozin treatment ameliorates hepatic fibrosis in patients with NAFLD. Thus, ipragliflozin might be effective for the treatment and prevention of NASH in patients with diabetes, as well as improving glycemic control and obesity. Therefore, SGLT2is may represent a therapeutic choice for patients with diabetes with NAFLD, but further larger studies are required to confirm these effects.

DOI： 10.1002/hep4.1696

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成人T細胞白血病に対する同種造血幹細胞移植後に発症した移植片対宿主病による中枢神経病変の1例

井手俊宏, 飯田紘太郎, 勝屋弘雄, 伊藤寛, 相島慎一, 原英夫

臨床神経学 62 ( 1 ) 33 - 38 2022.1 （ ISSN:0009-918X ）

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症例は54歳女性.2015年11月に急性型成人T細胞白血病(adult T cell leukemia,以下ATLと略記)を発症し,翌年3月に同種造血幹細胞移植を受けた.2019年5月に急激に認知機能障害が出現し,頭部MRIで大脳白質病変を認めた.髄液検査では蛋白の上昇を認めた.脳生検ではCD8陽性のT細胞を主体とする炎症細胞が白質へ浸潤していた.肺・腸管の慢性移植片対宿主病(graft versus host disease,以下GVHDと略記)の既往と病理所見から慢性GVHDの中枢神経病変(central nervous system involvement of GVHD,以下CNS-GVHDと略記)と診断した.ステロイドとミコフェノール酸モフェチルによる免疫療法を行い,認知機能障害と髄液所見の改善を得た.本症例はATLにおけるCNS-GVHDの初の報告であり,脳生検による診断の重要性と免疫療法の有効性を示した.(著者抄録)
Predictive value of cytokeratin-18 fragment levels for diagnosing steatohepatitis in patients with nonalcoholic fatty liver disease. International journal

Toshifumi Tada, Toshiji Saibara, Masafumi Ono, Hirokazu Takahashi, Yuichiro Eguchi, Hideyuki Hyogo, Miwa Kawanaka, Takashi Kumada, Hidenori Toyoda, Satoshi Yasuda, Atsushi Nakajima, Masato Yoneda, Saiyu Tanaka, Keiji Shimada, Hideaki Hoshino, Shinichi Aishima, Masayoshi Kage, Yoshio Sumida

European journal of gastroenterology & hepatology 33 ( 11 ) 1451 - 1458 2021.11

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DOI： 10.1097/MEG.0000000000002176
Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis. International journal

Dolgormaa Gantumur, Norifumi Harimoto, Ryo Muranushi, Kouki Hoshino, Chingun Batbayar, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Takehiko Yokobori, Shinichi Aishima, Ken Shirabe

Hepatology research : the official journal of the Japan Society of Hepatology 51 ( 10 ) 1058 - 1063 2021.10

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DOI： 10.1111/hepr.13648
Intracranial Mönckeberg's Atherosclerosis Is Frequently Found in Autopsy Cases of Advanced Stage Malignancy with Cerebral Infarction. International journal

13 ( 20 ) 2021.10

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Cerebral infarction (CI) severely affects the prognosis of patients with malignancy. The aim of the study was to compare the pathology of CI between cases with and without malignancy focusing on intracranial Mönckeberg's atherosclerosis. Among 778 autopsy cases of craniotomy, 53 cases of "cerebral infarction without malignancy group" (CI group), 50 cases of "malignant tumor without CI group" (MT group), and 39 cases of "cerebral infarction with malignancy group" (CM group) were identified. Mönckeberg's atherosclerosis was mainly found in the basal ganglia and its prevalence in the CM group (38.5%) was significantly higher than in the MT group (12.0%, p = 0.005), and apparently higher than in the CI group (18.9%, p = 0.057). The CI group was significantly older, had higher BMIs, and a greater prevalence of hypertension and atrial fibrillation compared to the CM group. In addition, the prevalence of chronic renal disease was significantly lower in the CM group (2.6%, p = 0.012) than in the CI group (20.8%). Our results indicated that Mönckeberg's atherosclerosis was often found in the basal ganglia of CM cases and that intracranial Mönckeberg's atherosclerosis is a potential risk factor for CI in patients with advanced stage malignancy.

DOI： 10.3390/cancers13205234
Effect of skin-capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease. International journal

Syunichiro Kimura, Kenichi Tanaka, Satoshi Oeda, Kaori Inoue, Chika Inadomi, Yoshihito Kubotsu, Wataru Yoshioka, Michiaki Okada, Hiroshi Isoda, Takuya Kuwashiro, Takumi Akiyama, Aya Kurashige, Ayaka Oshima, Mayumi Oshima, Yasue Matsumoto, Atsushi Kawaguchi, Keizo Anzai, Eisaburo Sueoka, Shinichi Aishima, Hirokazu Takahashi

Scientific reports 11 ( 1 ) 15641 - 15641 2021.8

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DOI： 10.1038/s41598-021-94970-3
Prognostic implications of the coexisting precursor lesion types in invasive gallbladder cancer. International journal

Naoki Mochidome, Yutaka Koga, Yoshihiro Ohishi, Tetsuyuki Miyazaki, Ryota Matsuda, Yuichi Yamada, Shinichi Aishima, Masafumi Nakamura, Yoshinao Oda

Human pathology 114 44 - 53 2021.8

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DOI： 10.1016/j.humpath.2021.05.001
Infiltration of CD1a-positive dendritic cells in advanced laryngeal cancer correlates with unfavorable outcomes post-laryngectomy. International journal

Akimichi Minesaki, Keita Kai, Yuichiro Kuratomi, Shinichi Aishima

BMC cancer 21 ( 1 ) 973 - 973 2021.8

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DOI： 10.1186/s12885-021-08715-6
Gut microbiota composition associated with hepatic fibrosis in non-obese patients with non-alcoholic fatty liver disease. International journal

Michihiro Iwaki, Takaomi Kessoku, Anna Ozaki, Yuki Kasai, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, Masato Yoneda, Ayako Maeda, Yoshiki Tanaka, Shunji Nakajima, Hiroshi Ohno, Haruki Usuda, Miwa Kawanaka, Takumi Kawaguchi, Takuji Torimura, Masayoshi Kage, Hideyuki Hyogo, Hirokazu Takahashi, Yuichiro Eguchi, Shinichi Aishima, Koichiro Wada, Noritoshi Kobayashi, Yoshio Sumida, Satoru Saito, Atsushi Nakajima

Journal of gastroenterology and hepatology 36 ( 8 ) 2275 - 2284 2021.8

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DOI： 10.1111/jgh.15487
A deep learning model to detect pancreatic ductal adenocarcinoma on endoscopic ultrasound-guided fine-needle biopsy. International journal

Yoshiki Naito, Masayuki Tsuneki, Noriyoshi Fukushima, Yutaka Koga, Michiyo Higashi, Kenji Notohara, Shinichi Aishima, Nobuyuki Ohike, Takuma Tajiri, Hiroshi Yamaguchi, Yuki Fukumura, Motohiro Kojima, Kenichi Hirabayashi, Yoshihiro Hamada, Tomoko Norose, Keita Kai, Yuko Omori, Aoi Sukeda, Hirotsugu Noguchi, Kaori Uchino, Junya Itakura, Yoshinobu Okabe, Yuichi Yamada, Jun Akiba, Fahdi Kanavati, Yoshinao Oda, Toru Furukawa, Hirohisa Yano

Scientific reports 11 ( 1 ) 8454 - 8454 2021.4

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DOI： 10.1038/s41598-021-87748-0
Unclassified hepatocellular adenoma with beta-catenin mutation: a case report. International journal

Ryo Muranushi, Kenichiro Araki, Norifumi Harimoto, Takehiko Yokobori, Kouki Hoshino, Kei Hagiwara, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Shinichi Aishima, Ken Shirabe

Surgical case reports 7 ( 1 ) 46 - 46 2021.2

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DOI： 10.1186/s40792-021-01131-9
Exploiting synergistic effect of externally loaded bFGF and endogenous growth factors for accelerated wound healing using heparin functionalized PCL/gelatin co-spun nanofibrous patches

Akshat Joshi, Zhe Xu, Yasuhiro Ikegami, Kozue Yoshida, Yusuke Sakai, Akshay Joshi, Tejinder Kaur, Yosuke Nakao, Yo ichi Yamashita, Hideo Baba, Shinichi Aishima, Neetu Singh, Hiroyuki Ijima

Chemical Engineering Journal 404 2021.1

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DOI： 10.1016/j.cej.2020.126518
Immunohistochemical analysis of the aggregation of CD1a-positive dendritic cells in resected specimens and its association with surgical outcomes for patients with gallbladder cancer. International journal

Keita Kai, Tomokazu Tanaka, Takao Ide, Atsushi Kawaguchi, Hirokazu Noshiro, Shinichi Aishima

Translational oncology 14 ( 1 ) 100923 - 100923 2021.1

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DOI： 10.1016/j.tranon.2020.100923
Decrease in fasting insulin secretory function correlates with significant liver fibrosis in Japanese non-alcoholic fatty liver disease patients. International journal

Norimasa Araki, Hirokazu Takahashi, Ayako Takamori, Yoichiro Kitajima, Hideyuki Hyogo, Yoshio Sumida, Saiyu Tanaka, Keizo Anzai, Shinichi Aishima, Kazuaki Chayama, Kazuma Fujimoto, Yuichiro Eguchi

JGH open : an open access journal of gastroenterology and hepatology 4 ( 5 ) 929 - 936 2020.10

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DOI： 10.1002/jgh3.12367
Histopathological findings of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Masayoshi Kage, Shinichi Aishima, Hironori Kusano, Hirohisa Yano

Journal of medical ultrasonics (2001) 47 ( 4 ) 549 - 554 2020.10

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DOI： 10.1007/s10396-020-01061-3
Guidance for diagnosing autoimmune pancreatitis with biopsy tissues. International journal

Kenji Notohara, Terumi Kamisawa, Noriyoshi Fukushima, Toru Furukawa, Takuma Tajiri, Hiroshi Yamaguchi, Shinichi Aishima, Yuki Fukumura, Kenichi Hirabayashi, Eisuke Iwasaki, Atsushi Kanno, Satomi Kasashima, Atsuhiro Kawashima, Motohiro Kojima, Kensuke Kubota, Yasuhiro Kuraishi, Tomoko Mitsuhashi, Yoshiki Naito, Itaru Naitoh, Hiroshi Nakase, Takayoshi Nishino, Nobuyuki Ohike, Junichi Sakagami, Kyoko Shimizu, Masahiro Shiokawa, Takeshi Uehara, Tsukasa Ikeura, Shigeyuki Kawa, Kazuichi Okazaki

Pathology international 70 ( 10 ) 699 - 711 2020.10

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DOI： 10.1111/pin.12994
Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study. International journal

Yuji Ogawa, Takashi Kobayashi, Yasushi Honda, Takaomi Kessoku, Wataru Tomeno, Kento Imajo, Takashi Nakahara, Satoshi Oeda, Yuko Nagaoki, Yuichiro Amano, Tatsuya Ando, Megumi Hirayama, Osamu Isono, Hidenori Kamiguchi, Hiroshi Nagabukuro, Shinji Ogawa, Yoshinori Satomi, Yusuke Saigusa, Hirokazu Takahashi, Hideyuki Hyogo, Masato Yoneda, Satoru Saito, Takeharu Yamanaka, Shinichi Aishima, Yuichiro Eguchi, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakajima

Hepatology research : the official journal of the Japan Society of Hepatology 50 ( 8 ) 955 - 965 2020.8

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DOI： 10.1111/hepr.13528
Clinicopathological characteristics of combined hepatocellular cholangiocarcinoma from the viewpoint of patient prognosis after hepatic resection: High rate of early recurrence and its predictors. International journal

Yo-Ichi Yamashita, Shinichi Aishima, Yosuke Nakao, Tomoharu Yoshizumi, Hiroaki Nagano, Tamotsu Kuroki, Yuko Takami, Takao Ide, Masayuki Ohta, Mitsuhisa Takatsuki, Atsushi Nanashima, Fuminori Ishii, Kenji Kitahara, Satoshi Iino, Toru Beppu, Hideo Baba, Susumu Eguchi

Hepatology research : the official journal of the Japan Society of Hepatology 50 ( 7 ) 863 - 870 2020.7

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DOI： 10.1111/hepr.13507
Diagnostic accuracy of FibroScan-AST score to identify non-alcoholic steatohepatitis with significant activity and fibrosis in Japanese patients with non-alcoholic fatty liver disease: Comparison between M and XL probes. International journal

Satoshi Oeda, Hirokazu Takahashi, Kento Imajo, Yuya Seko, Takashi Kobayashi, Yuji Ogawa, Michihisa Moriguchi, Masato Yoneda, Keizo Anzai, Hiroyuki Irie, Eisaburo Sueoka, Shinichi Aishima, Masayoshi Kage, Yoshito Itoh, Yuichiro Eguchi, Atsushi Nakajima

Hepatology research : the official journal of the Japan Society of Hepatology 50 ( 7 ) 831 - 839 2020.7

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DOI： 10.1111/hepr.13508
Accuracy of the Enhanced Liver Fibrosis test, and combination of the Enhanced Liver Fibrosis and non-invasive tests for the diagnosis of advanced liver fibrosis in patients with non-alcoholic fatty liver disease. International journal

Chika Inadomi, Hirokazu Takahashi, Yuji Ogawa, Satoshi Oeda, Kento Imajo, Yoshihito Kubotsu, Kenichi Tanaka, Takaomi Kessoku, Michiaki Okada, Hiroshi Isoda, Takumi Akiyama, Hideaki Fukushima, Masato Yoneda, Keizo Anzai, Shinichi Aishima, Atsushi Nakajima, Yuichiro Eguchi

Hepatology research : the official journal of the Japan Society of Hepatology 50 ( 6 ) 682 - 692 2020.6

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DOI： 10.1111/hepr.13495
Discordant pathological diagnosis of non-alcoholic fatty liver disease: A prospective multicenter study. International journal

Takuya Kuwashiro, Hirokazu Takahashi, Hideyuki Hyogo, Yuji Ogawa, Kento Imajo, Masato Yoneda, Takashi Nakahara, Satoshi Oeda, Kenichi Tanaka, Yuichiro Amano, Shinji Ogawa, Atsushi Kawaguchi, Shinichi Aishima, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakajima, Yuichiro Eguchi

JGH open : an open access journal of gastroenterology and hepatology 4 ( 3 ) 497 - 502 2020.6

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DOI： 10.1002/jgh3.12289
Unclassified hepatocellular adenoma with histological brown pigment deposition and serum PIVKA-II level elevation: a case report. International journal

Kouki Hoshino, Norifumi Harimoto, Ryo Muranushi, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Ran Tomomasa, Sumihito Nobusawa, Shinichi Aishima, Osamu Nakashima, Ken Shirabe

Surgical case reports 6 ( 1 ) 94 - 94 2020.5

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DOI： 10.1186/s40792-020-00853-6
Accumulation of Astrocytic Aquaporin 4 and Aquaporin 1 in Prion Protein Plaques. International journal

Shoko Sadashima, Hiroyuki Honda, Satoshi O Suzuki, Masahiro Shijo, Shinichi Aishima, Keita Kai, Junichi Kira, Toru Iwaki

Journal of neuropathology and experimental neurology 79 ( 4 ) 419 - 429 2020.4

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DOI： 10.1093/jnen/nlaa010
Accuracy of liver stiffness measurement and controlled attenuation parameter using FibroScan® M/XL probes to diagnose liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease: a multicenter prospective study.

55 ( 4 ) 428 - 440 2020.4

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Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Few studies have evaluated both liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease (NAFLD) using both FibroScan® M and XL probes. This study was performed to investigate the accuracy of both FibroScan® probes to diagnose liver fibrosis and steatosis in patients with NAFLD. METHODS: We prospectively enrolled 137 consecutive patients with clinically suspected NAFLD in our joint-research facilities. Liver biopsies, liver stiffness measurements (LSMs), and controlled attenuation parameter (CAP) measurements were performed, and 122 patients with NAFLD diagnosed pathologically by central pathologists were included in the final analysis. RESULTS: Reliable LSM results were obtained in 85.2% (M) and 89.3% (XL) of patients, and CAP was reliable in 90.2% (M) and 90.2% (XL). The median LSM was significantly lower with the XL than M probe, and CAP was significantly higher with the XL than M probe. The optimal cut-off values for diagnosing the fibrosis stage were lower for LSM with the XL than M probe (stage ≥ 2, 6.7 vs. 7.0; stage ≥ 3, 8.2 vs. 10.8; stage 4, 14.3 vs. 16.8, respectively), whereas those of CAP were higher for the XL than M probe (score of ≥ 2, 273 vs. 267; score of 3, 302 vs. 286, respectively). There were no significant differences in accuracy of the LSM and CAP between the probes. CONCLUSIONS: Liver fibrosis and steatosis could be equally evaluated with FibroScan® M and XL probes in patients with NAFLD. There was no significant difference in diagnostic accuracy between the two probes using probe-specific cut-off values.

DOI： 10.1007/s00535-019-01635-0
Decreased cytokeratin 7 expression correlates with the progression of cervical squamous cell carcinoma and poor patient outcomes. International journal

Mariko Hashiguchi, Masanori Masuda, Keita Kai, Yoshifumi Nakao, Atsushi Kawaguchi, Masatoshi Yokoyama, Shinichi Aishima

The journal of obstetrics and gynaecology research 45 ( 11 ) 2228 - 2236 2019.11

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DOI： 10.1111/jog.14108
Fairly rare small-diameter hepatocellular carcinoma with right adrenal gland metastasis having an inferior vena cava tumor thrombus: a case report. International journal

Takamichi Igarashi, Norifumi Harimoto, Nozomi Matsumura, Masaya Sugiyama, Kenichiro Araki, Takehiko Yokobori, Takashi Kosone, Hitoshi Takagi, Shinichi Aishima, Hideaki Yokoo, Ken Shirabe

Surgical case reports 5 ( 1 ) 170 - 170 2019.11

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DOI： 10.1186/s40792-019-0705-7
A unique autopsy case of ascending aortic dissection caused by giant cell arteritis without drug therapy. International journal

Yukari Takase, Yosuke Murakami, Jumpei Nishi, Osamu Tokunaga, Toshiharu Matsumoto, Shinichi Aishima

Pathology international 69 ( 10 ) 614 - 618 2019.10

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DOI： 10.1111/pin.12845
Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases. International journal

Hiroyuki Honda, Masaki Matsumoto, Masahiro Shijo, Hideomi Hamasaki, Shoko Sadashima, Satoshi O Suzuki, Shinichi Aishima, Keita Kai, Keiichi I Nakayama, Naokazu Sasagasako, Toru Iwaki

Journal of neuropathology and experimental neurology 78 ( 10 ) 922 - 929 2019.10

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DOI： 10.1093/jnen/nlz075
CXCL12 expression in intrahepatic cholangiocarcinoma is associated with metastasis and poor prognosis. International journal

Tatsunori Miyata, Yo-Ichi Yamashita, Tomoharu Yoshizumi, Masayuki Shiraishi, Masayuki Ohta, Susumu Eguchi, Shinichi Aishima, Hikaru Fujioka, Hideo Baba

Cancer science 110 ( 10 ) 3197 - 3203 2019.10

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DOI： 10.1111/cas.14151
IFN-γ Promotes Epithelial-Mesenchymal Transition and the Expression of PD-L1 in Pancreatic Cancer. International journal

240 115 - 123 2019.8

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BACKGROUND: Tumor immune reactions not only provide host defense but also accelerate tumor immune escape and phenotype switching. Here, we examined the association of programmed cell death ligand 1 (PD-L1) expression with epithelial-mesenchymal transition (EMT)-associated markers in pancreatic ductal adenocarcinoma (PDA) within the context of the tumor microenvironment. MATERIALS AND METHODS: PDA samples from 36 patients were analyzed for PD-L1, vimentin, E-cadherin, and Snail expressions and for PDA cell and immune cell infiltration. PD-L1 expression and EMT in PDA cell lines under conditions of altering interferon gamma (IFN-γ) signals were also assessed. RESULTS: Immunohistochemistry revealed a significant correlation between vimentin and PD-L1 expression, whereas double staining showed them to be simultaneously expressed by PDA cells. Positive vimentin expression was associated with the infiltration of a lower number of CD8+ T cells and a higher number of FoxP3+ cells and poor patient prognosis (P = 0.03). PDA tumor cells promoted PD-L1 expression and EMT under the presence of IFN-γ, which was inhibited by the signal transducer and activator of transcription (STAT)1 small interfering RNA. CONCLUSIONS: Strong correlations were observed between PD-L1 expression, EMT, and the immunosuppressive tumor microenvironment. Targeting STAT1 combined with PD-1/PD-L1 immunotherapy may improve outcomes for patients with PDA.

DOI： 10.1016/j.jss.2019.02.038
Primary mucoepidermoid carcinoma of the liver with CRTC1-MAML2 fusion: a case report. International journal

Jiro Watanabe, Keita Kai, Ken Tanikawa, Mamoru Hiraki, Naohisa Mizukami, Shinichi Aishima, Takafumi Nakano, Hidetaka Yamamoto

Diagnostic pathology 14 ( 1 ) 84 - 84 2019.7

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DOI： 10.1186/s13000-019-0863-8
Transferrin receptor 1 overexpression is associated with tumour de-differentiation and acts as a potential prognostic indicator of hepatocellular carcinoma. International journal

Makiko Adachi, Keita Kai, Koutaro Yamaji, Takao Ide, Hirokazu Noshiro, Atsushi Kawaguchi, Shinichi Aishima

Histopathology 75 ( 1 ) 63 - 73 2019.7

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DOI： 10.1111/his.13847
External validation of ADNEX MR SCORING system: a single-centre retrospective study

K. Sasaguri, K. Yamaguchi, T. Nakazono, M. Mizuguchi, S. Aishima, M. Yokoyama, H. Irie

Clinical Radiology 74 ( 2 ) 131 - 139 2019.2

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Language：Others Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.crad.2018.10.014
Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation. International journal

Keiichiro Okuyama, Yoshihiko Kitajima, Noriyuki Egawa, Hiroshi Kitagawa, Kotaro Ito, Shinichi Aishima, Kazuyoshi Yanagihara, Tomokazu Tanaka, Hirokazu Noshiro

Scientific reports 9 ( 1 ) 2822 - 2822 2019.2

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DOI： 10.1038/s41598-019-39563-x
Formalin fixation on HER-2 and PD-L1 expression in gastric cancer: A pilot analysis using the same surgical specimens with different fixation times. International journal

Keita Kai, Yukie Yoda, Atsushi Kawaguchi, Akimichi Minesaki, Hironori Iwasaki, Shinichi Aishima, Hirokazu Noshiro

World journal of clinical cases 7 ( 4 ) 419 - 430 2019.2

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.12998/wjcc.v7.i4.419
Occult HBV infection status and its impact on surgical outcomes in patients with curative resection for HCV-associated hepatocellular carcinoma. International journal

Koutaro Yamaji, Keita Kai, Sho Komukai, Hiroki Koga, Takao Ide, Atsushi Kawaguchi, Hirokazu Noshiro, Shinichi Aishima

Hepatobiliary surgery and nutrition 7 ( 6 ) 443 - 453 2018.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.21037/hbsn.2018.10.01
Primary intrahepatic cholangiocarcinoma with sarcomatous stroma: case report and review of the literature. International journal

Kyohei Yugawa, Tomoharu Yoshizumi, Yohei Mano, Noboru Harada, Shinji Itoh, Toru Ikegami, Yuji Soejima, Nobuhiro Fujita, Kenichi Kohashi, Shinichi Aishima, Yoshinao Oda, Masaki Mori

Surgical case reports 4 ( 1 ) 138 - 138 2018.11

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DOI： 10.1186/s40792-018-0543-z
Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide. International journal

Toshihiko Ando, Kensuke Kojima, Haruhiko Sano, Keisuke Kidoguchi, Kana Kusaba, Mariko Yoshimura, Masako Yokoo, Yasushi Kubota, Hideaki Nakamura, Yukari Takase, Shinichi Aishima, Shinya Kimura

Leukemia & lymphoma 59 ( 10 ) 2474 - 2477 2018.10

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DOI： 10.1080/10428194.2018.1427859
A case report of intracholecystic papillary neoplasm of the gallbladder resembling a submucosal tumor. International journal

Ryo Muranushi, Hideyuki Saito, Asuka Matsumoto, Toshihide Kato, Naritaka Tanaka, Kenji Nakazato, Nobuhiro Morinaga, Yoshinori Shitara, Masatoshi Ishizaki, Takatomo Yoshida, Shinichi Aishima, Ken Shirabe

Surgical case reports 4 ( 1 ) 124 - 124 2018.9

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s40792-018-0524-2
A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. International journal

Takayuki Fujii, Ryo Yamasaki, Kyoko Iinuma, Daisuke Tsuchimoto, Yoshinori Hayashi, Ban-Yu Saitoh, Takuya Matsushita, Mizuho A Kido, Shinichi Aishima, Hiroshi Nakanishi, Yusaku Nakabeppu, Jun-Ichi Kira

Annals of neurology 84 ( 2 ) 208 - 224 2018.8

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DOI： 10.1002/ana.25279
Synchronous mantle cell lymphoma and lung adenocarcinoma presenting in a pleural effusion: A rare tumour combination and a potential pitfall of cytodiagnosis

K. Kai, Y. Ryu, K. Kamochi, A. Nishioka, Y. Kubota, M. Nakamura, S. Kimura, E. Sueoka, S. Aishima

Cytopathology 29 ( 4 ) 400 - 402 2018.8

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Language：Others

DOI： 10.1111/cyt.12532
Neuroendocrine tumor of the pancreas with rhabdoid feature. International journal

Tetsuyuki Miyazaki, Shinichi Aishima, Minoru Fujino, Keigo Ozono, Yuichiro Kubo, Yasuhiro Ushijima, Takashi Osoegawa, Eikichi Ihara, Itou Tetsuhide, Takao Ohtsuka, Masafumi Nakamura, Yoshinao Oda

Virchows Archiv : an international journal of pathology 473 ( 2 ) 247 - 252 2018.8

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DOI： 10.1007/s00428-018-2398-x
Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. International journal

Yoshihiro Aiba, Kenichi Harada, Masahiro Ito, Takashi Suematsu, Shinichi Aishima, Yuki Hitomi, Nao Nishida, Minae Kawashima, Mitsuhisa Takatsuki, Susumu Eguchi, Shinji Shimoda, Hitomi Nakamura, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Kiyoshi Migita, Hiroshi Yatsuhashi, Katsushi Tokunaga, Minoru Nakamura

Scientific reports 8 ( 1 ) 11808 - 11808 2018.8

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DOI： 10.1038/s41598-018-30146-w
Fairly rare clear cell adenocarcinoma mimicking liver cancer: a case report. International journal

Norifumi Harimoto, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichirou Araki, Hayato Ikota, Masafumi Suyama, Takeshi Maki, Shinichi Aishima, Hiroyuki Kuwano, Ken Shirabe

Surgical case reports 4 ( 1 ) 97 - 97 2018.8

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DOI： 10.1186/s40792-018-0500-x
cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation. International journal

Elizabeth Brunt, Shinichi Aishima, Pierre-Alain Clavien, Kathryn Fowler, Zachary Goodman, Gregory Gores, Annette Gouw, Alex Kagen, David Klimstra, Mina Komuta, Fukuo Kondo, Rebecca Miksad, Masayuki Nakano, Yasuni Nakanuma, Irene Ng, Valerie Paradis, Young Nyun Park, Alberto Quaglia, Massimo Roncalli, Tania Roskams, Michiie Sakamoto, Romil Saxena, Christine Sempoux, Claude Sirlin, Ashley Stueck, Swan Thung, W M S Tsui, Xin-Wei Wang, Aileen Wee, Hirohisa Yano, Matthew Yeh, Yoh Zen, Jessica Zucman-Rossi, Neil Theise

Hepatology (Baltimore, Md.) 68 ( 1 ) 113 - 126 2018.7

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DOI： 10.1002/hep.29789
Microvascular invasion of single small hepatocellular carcinoma ≤3 cm: Predictors and optimal treatments.

2 ( 3 ) 197 - 203 2018.5

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BACKGROUND: Small hepatocellular carcinomas (HCC ≤3 cm) are generally considered to have low malignant potential; however, some of them display pathological microvascular invasion (MVI). METHODS: Between 1991 and 2013, 414 patients with a single HCC ≤3 cm underwent curative hepatic resection (HR). Predictors for MVI were identified. Using another cohort (149 patients during 2000-2014), our predictors for MVI in HCC ≤3 cm were validated. In 428 patients with a single HCC ≤3 cm who had predictors for MVI, survival was compared among anatomical HR (n = 149), partial HR (n = 227), and radiofrequency ablation (RFA) (n = 52). RESULTS: The positive rate of MVI reached 40.6% (168/414 patients). Independent predictors for MVI were as follows: tumor diameter ≥2 cm (odds ratio 1.84, P = .0052), alpha-fetoprotein (AFP) ≥200 ng/mL (odds ratio 1.82, P = .0466), and des-gamma-carboxy prothrombin (DCP) ≥40 mAU/mL (odds ratio 1.79, P = .0126). Matching at least one predictor among these three could predict MVI in HCC ≤3 cm well (sensitivity 82.8%, positive predictive value [PPV] 48.7%). This criterion could also predict MVI in HCC ≤3 cm well in another cohort (sensitivity 82.8%, PPV 30.3%). In patients with single HCC ≤3 cm matching our criterion for predicting MVI, anatomical HR led to significantly better survival in both disease-free (hazard ratio 0.689, P = .0231) and overall (hazard ratio 0.589, P = .0316) survivals. CONCLUSION: Matching at least one factor among three (tumor diameter ≥2 cm, AFP ≥200 ng/mL, or DCP ≥40 mAU/mL) can predict MVI in HCC ≤3 cm. In such patients, anatomical HR would be recommended to improve survival.

DOI： 10.1002/ags3.12057
Resected primary mucinous cholangiocarcinoma of the liver. International journal

Kei Hagiwara, Kenichiro Araki, Takahiro Yamanaka, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Norifumi Harimoto, Hiroyuki Kuwano, Sumito Nobusawa, Shinichi Aishima, Ken Shirabe

Surgical case reports 4 ( 1 ) 41 - 41 2018.5

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DOI： 10.1186/s40792-018-0450-3
A dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features. International journal

Keita Kai, Kazuma Udo, Ken Yamaguchi, Shohei Tobu, Mitsuru Noguchi, Shinichi Aishima

Pathology international 68 ( 4 ) 262 - 264 2018.4

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DOI： 10.1111/pin.12645
Clear Cell Carcinoma of the Uterine Cervix Presented as a Submucosal Tumor Arising in a Background of Cervical Endometriosis. International journal

Mariko Hashiguchi, Keita Kai, Satoshi Nishiyama, Yoshifumi Nakao, Masatoshi Yokoyama, Shinichi Aishima

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 37 ( 1 ) 88 - 92 2018.1

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DOI： 10.1097/PGP.0000000000000386
Correlation between smoking habit and surgical outcomes on viral-associated hepatocellular carcinomas. International journal

Keita Kai, Sho Komukai, Hiroki Koga, Koutaro Yamaji, Takao Ide, Atsushi Kawaguchi, Shinichi Aishima, Hirokazu Noshiro

World journal of gastroenterology 24 ( 1 ) 58 - 68 2018.1

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DOI： 10.3748/wjg.v24.i1.58
Immunoserological and histological differences between autoimmune hepatitis with acute presentation and chronic autoimmune hepatitis. International journal

Kazufumi Dohmen, Hirofumi Tanaka, Masatora Haruno, Shinichi Aishima

Hepatology research : the official journal of the Japan Society of Hepatology 47 ( 13 ) 1375 - 1382 2017.12

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DOI： 10.1111/hepr.12875
Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma. International journal

Hiroki Koga, Keita Kai, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro

World journal of hepatology 9 ( 35 ) 1286 - 1295 2017.12

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DOI： 10.4254/wjh.v9.i35.1286
Colonic poorly differentiated adenocarcinoma with abundant cancer-associated fibroblasts diagnosed by trans-gastric endoscopic ultrasound-guided fine needle aspiration cytology

M. Yamasaki, K. Kai, A. Nomura, H. Kono, H. Kawakubo, Y. Sakata, M. Mizuguchi, S. Aishima

Cytopathology 28 ( 5 ) 442 - 444 2017.10

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Language：Others

DOI： 10.1111/cyt.12443
Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis. International journal

Kota Wakiyama, Yoshihiko Kitajima, Tomokazu Tanaka, Masao Kaneki, Kazuyoshi Yanagihara, Shinichi Aishima, Jun Nakamura, Hirokazu Noshiro

Scientific reports 7 ( 1 ) 12653 - 12653 2017.10

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DOI： 10.1038/s41598-017-12929-9
Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report. International journal

Norihiro Ishii, Kenichiro Araki, Takahiro Yamanaka, Tadashi Handa, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Shinichi Aishima, Hiroyuki Kuwano, Ken Shirabe

Surgical case reports 3 ( 1 ) 103 - 103 2017.9

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DOI： 10.1186/s40792-017-0377-0
Autopsy case of systemic EBV-positive T-cell lymphoma of childhood with marked hepatomegaly in a middle-aged man. International journal

Keita Kai, Futa Koga, Norimasa Araki, Takero Shindo, Yuichiro Eguchi, Shuji Toda, Shinichi Aishima

Pathology international 67 ( 8 ) 431 - 433 2017.8

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Language：English

DOI： 10.1111/pin.12549
SLC2A1/GLUT1 expression in mural nodules of intraductal papillary mucinous neoplasm of the pancreas. International journal

Yasunori Oda, Shinichi Aishima, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Tetsuyuki Miyazaki, Masao Tanaka, Yoshinao Oda

Human pathology 65 71 - 78 2017.7

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DOI： 10.1016/j.humpath.2017.03.008
The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer. International journal

Daisuke Imai, Tomoharu Yoshizumi, Shinji Okano, Hideaki Uchiyama, Toru Ikegami, Norifumi Harimoto, Shinji Itoh, Yuji Soejima, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara

Cancer medicine 6 ( 7 ) 1614 - 1626 2017.7

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DOI： 10.1002/cam4.1087
Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma. International journal

Huanlin Wang, Kenichi Kohashi, Tomoharu Yoshizumi, Yukihiko Okumura, Yuki Tanaka, Masahiro Shimokawa, Takeshi Iwasaki, Shinichi Aishima, Yoshihiko Maehara, Yoshinao Oda

Human pathology 64 69 - 75 2017.6

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DOI： 10.1016/j.humpath.2017.03.007
Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma. International journal

Yoshiki Asayama, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Nobuhiro Fujita, Takao Ohtsuka, Tomoharu Yoshizumi, Shinichi Aishima, Yoshinao Oda, Hiroshi Honda

European radiology 27 ( 6 ) 2563 - 2569 2017.6

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DOI： 10.1007/s00330-016-4621-y
Pathology of intrahepatic cholangiocarcinoma: Peripheral and perihilar type

Shinichi Aishima

Pathology of the Bile Duct 149 - 161 2017.5

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Language：Others

DOI： 10.1007/978-981-10-3500-5_12
Hepatobiliary and Pancreatic: Hepatocellular carcinoma developed with angiomyolipoma

T. Miyata, Y. Yamashita, T. Yamao, N. Umezaki, M. Tsukamoto, Y. Kitano, K. Yamamura, K. Arima, T. Kaida, S. Nakagawa, K. Imai, D. Hashimoto, A. Chikamoto, T. Ishiko, T. Asato, Y. Mikami, S. Aishima, H. Baba

Journal of Gastroenterology and Hepatology (Australia) 32 ( 3 ) 547 2017.3

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DOI： 10.1111/jgh.13655
Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma. International journal

Keita Kai, Hiroki Koga, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro

World journal of gastroenterology 23 ( 8 ) 1397 - 1405 2017.2

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DOI： 10.3748/wjg.v23.i8.1397
Mass-forming intrahepatic cholangiocarcinoma: Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings. International journal

Nobuhiro Fujita, Yoshiki Asayama, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Koichiro Moirta, Ken Shirabe, Shinichi Aishima, Huanlin Wang, Yoshinao Oda, Hiroshi Honda

European radiology 27 ( 2 ) 498 - 506 2017.2

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DOI： 10.1007/s00330-016-4386-3
Extrahepatic cholangiocarcinoma and pancreatic duct adenocarcinoma

Shinichi Aishima

Biliary Diseases with Pancreatic Counterparts: A New Disease Concept 85 - 109 2017.1

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Inverse correlation between CD8+ inflammatory cells and E-cadherin expression in gallbladder cancer: Tissue microarray and imaging analysis. International journal

Keita Kai, Masanori Masuda, Shinichi Aishima

World journal of clinical cases 5 ( 1 ) 1 - 8 2017.1

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DOI： 10.12998/wjcc.v5.i1.1
Clinical Significances of Preoperative Classification of Intrahepatic Cholangiocarcinoma: Different Characteristics of Perihilar vs. Peripheral ICC. International journal

Yo-Ichi Yamashita, Huanlin Wang, Takeshi Kurihara, Eiji Tsujita, Akihiro Nishie, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Shinichi Aishima, Hideo Baba

Anticancer research 36 ( 12 ) 6563 - 6569 2016.12

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DOI： 10.21873/anticanres.11260
Fatty change in moderately and poorly differentiated hepatocellular carcinoma on MRI: a possible mechanism related to decreased arterial flow

Y. Asayama, A. Nishie, K. Ishigami, Y. Ushijima, Y. Takayama, D. Okamoto, N. Fujita, Y. Kubo, S. Aishima, T. Yoshizumi, H. Honda

Clinical Radiology 71 ( 12 ) 1277 - 1283 2016.12

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DOI： 10.1016/j.crad.2016.04.020
Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1α and malignant potential in pancreatic neuroendocrine tumors. International journal

12 ( 5 ) 3337 - 3343 2016.11

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The present study aimed to investigate the prognostic usefulness of the expression of glucose transporter type 1 (GLUT-1) and GLUT-2, hypoxia-inducible factor 1α (HIF-1α) and insulin-like growth factor II messenger RNA-binding protein 3 (IMP3) in pancreatic neuroendocrine tumors (pNETs). Immunohistochemical staining for GLUT-1, GLUT-2, HIF-1α and IMP3 was performed in 70 pNET specimens. The expression of GLUT-1 and HIF-1α was significantly higher in the World Health Organization grade 2 (G2), neuroendocrine carcinoma cases and mixed-type pNETs compared with the G1 cases. Vessel invasion, a high Ki-67 labeling index and a high mitotic count were significantly more frequent in the GLUT-1- and HIF-1α-positive cases compared with the negative cases. Lymph node metastasis was significantly higher in the GLUT-1-positive cases than in the negative cases. Insulin expression was significantly higher in the IMP3-positive cases than the negative cases. The GLUT-1 expression group experienced a significantly poor disease-free survival rate compared with the negative GLUT-1 expression group. HIF-1α expression was significantly correlated with poor disease-free survival and overall survival rates. A multivariate analysis revealed that lymph node metastasis was an independent risk factor for disease-free survival in all cases. In the G1/G2 group, tumor size and lymph node metastasis were independent risk factors for disease-free survival. Overall, the results suggested that GLUT-1 is a useful prognostic biomarker for pNETs.

DOI： 10.3892/ol.2016.5092
Malignant transformation of hepatocellular adenoma with bone marrow metaplasia arising in glycogen storage disease type I: A case report. International journal

Tomohiro Iguchi, Motoyuki Yamagata, Takashi Sonoda, Kimihiko Yanagita, Tetsuhiro Fukahori, Eiji Tsujita, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara

Molecular and clinical oncology 5 ( 5 ) 599 - 603 2016.11

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Effect of EGFR and p-AKT Overexpression on Chromosomal Instability in Gastric Cancer. International journal

Yuichi Hisamatsu, Eiji Oki, Hajime Otsu, Koji Ando, Hiroshi Saeki, Eriko Tokunaga, Shinichi Aishima, Masaru Morita, Yoshinao Oda, Yoshihiko Maehara

Annals of surgical oncology 23 ( 6 ) 1986 - 92 2016.6

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DOI： 10.1245/s10434-016-5097-3
Spalt-like transcription factor 4 immunopositivity is associated with epithelial cell adhesion molecule expression in combined hepatocellular carcinoma and cholangiocarcinoma. International journal

Yuki Tanaka, Shinichi Aishima, Kenichi Kohashi, Yukihiko Okumura, Huanlin Wang, Tomoyuki Hida, Kazuhiro Kotoh, Ken Shirabe, Yoshihiko Maehara, Ryoichi Takayanagi, Yoshinao Oda

Histopathology 68 ( 5 ) 693 - 701 2016.4

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DOI： 10.1111/his.12806
Cytokeratin immunohistochemistry improves interobserver variability between unskilled pathologists in the evaluation of tumor budding in T1 colorectal cancer. International journal

Keita Kai, Shinichi Aishima, Shigehisa Aoki, Yukari Takase, Kazuyoshi Uchihashi, Masanori Masuda, Aki Nishijima-Matsunobu, Mihoko Yamamoto, Kousuke Ide, Atsushi Nakayama, Makiko Yamasaki, Shuji Toda

Pathology international 66 ( 2 ) 75 - 82 2016.2

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DOI： 10.1111/pin.12374
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. International journal

113 ( 1 ) E71-80 - E80 2016.1

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Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double deficiency in mouse liver (LMob1DKO) results in hyperplasia of oval cells and immature cholangiocytes accompanied by inflammatory cell infiltration and fibrosis. More than half of mutant mice die within 3 wk of birth. All survivors eventually develop liver cancers, particularly combined hepatocellular and cholangiocarcinomas (cHC-CCs) and intrahepatic cholangiocellular carcinomas (ICCs), and die by age 60 wk. Because this phenotype is the most severe among mutant mice lacking a Hippo signaling component, MOB1A/1B constitute the critical hub of Hippo signaling in mammalian liver. LMob1DKO liver cells show hyperproliferation, increased cell saturation density, hepatocyte dedifferentiation, enhanced epithelial-mesenchymal transition and cell migration, and elevated transforming growth factor beta(TGF-β)2/3 production. These changes are strongly dependent on Yes-Associated Protein-1 (Yap1) and partially dependent on PDZ-binding motif (Taz) and Tgfbr2, but independent of connective tissue growth factor (Ctgf). In human liver cancers, YAP1 activation is frequent in cHC-CCs and ICCs and correlates with SMAD family member 2 activation. Drug screening revealed that antiparasitic macrocyclic lactones inhibit YAP1 activation in vitro and in vivo. Targeting YAP1/TAZ with these drugs in combination with inhibition of the TGF-β pathway may be effective treatment for cHC-CCs and ICCs.

DOI： 10.1073/pnas.1517188113
Predictors and Diagnostic Strategies for Early-Stage Pancreatic Ductal Adenocarcinoma: A Retrospective Study. International journal

Hideyo Kimura, Takao Ohtsuka, Taketo Matsunaga, Yusuke Watanabe, Koji Tamura, Noboru Ideno, Teppei Aso, Tetsuyuki Miyazaki, Takashi Osoegawa, Shinichi Aishima, Yoshihiro Miyasaka, Junji Ueda, Yasuhiro Ushijima, Hisato Igarashi, Tetsuhide Ito, Shunichi Takahata, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

Pancreas 44 ( 7 ) 1148 - 54 2015.10

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DOI： 10.1097/MPA.0000000000000393
Impact of GATA-3 and FOXA1 expression in patients with hormone receptor-positive/HER2-negative breast cancer.

Yuichi Hisamatsu, Eriko Tokunaga, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Yuichiro Nakashima, Kenji Taketani, Shinichi Aishima, Yoshinao Oda, Masaru Morita, Yoshihiko Maehara

Breast cancer (Tokyo, Japan) 22 ( 5 ) 520 - 8 2015.9

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DOI： 10.1007/s12282-013-0515-x
Predictors of Microvascular Invasion in Hepatocellular Carcinoma. International journal

Yo-Ichi Yamashita, Ken Shirabe, Shinichi Aishima, Yoshihiko Maehara

Digestive diseases (Basel, Switzerland) 33 ( 5 ) 655 - 60 2015.9

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DOI： 10.1159/000438475
Granulomatous reaction in hepatic inflammatory angiomyolipoma after chemoembolization and spontaneous rupture. International journal

Keita Kai, Atsushi Miyosh, Shinichi Aishima, Kota Wakiyama, Shunya Nakashita, Shinji Iwane, Shinya Azama, Hiroyuki Irie, Hirokazu Noshiro

World journal of gastroenterology 21 ( 32 ) 9675 - 82 2015.8

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DOI： 10.3748/wjg.v21.i32.9675
Surgical Outcomes of Hepatic Resection for Hepatitis B Virus Surface Antigen-Negative and Hepatitis C Virus Antibody-Negative Hepatocellular Carcinoma. International journal

Yo-Ichi Yamashita, Daisuke Imai, Yuki Bekki, Koichi Kimura, Yoshiriro Matsumoto, Hidekazu Nakagawara, Toru Ikegami, Tomoharu Yoshizumi, Ken Shirabe, Shinichi Aishima, Yoshihiko Maehara

Annals of surgical oncology 22 ( 7 ) 2279 - 85 2015.7

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DOI： 10.1245/s10434-014-4261-x
New Pathologic Stratification of Microvascular Invasion in Hepatocellular Carcinoma: Predicting Prognosis After Living-donor Liver Transplantation. International journal

Tomohiro Iguchi, Ken Shirabe, Shinichi Aishima, Huanlin Wang, Nobuhiro Fujita, Mizuki Ninomiya, Yo-ichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Tomoharu Yoshizumi, Yoshinao Oda, Yoshihiko Maehara

Transplantation 99 ( 6 ) 1236 - 42 2015.6

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DOI： 10.1097/TP.0000000000000489
桂枝加竜骨牡蛎湯，辛夷清肺湯による薬物性肝障害の1例

道免和文, 田中博文, 春野政虎, 下田慎治, 相島慎一

日本消化器病学会雑誌 112 ( 6 ) 1054 - 9 2015.6

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症例は35歳時に桂枝加竜骨牡蛎湯による肝障害歴のある43歳の女性．副鼻腔炎に対し処方された辛夷清肺湯の内服後に総ビリルビン，AST，ALTの上昇がみられ，当科に紹介入院となった．辛夷清肺湯の薬物性肝障害と診断し，薬剤の中止で肝機能は正常化した．肝組織像もリンパ球・好酸球浸潤，巣状壊死の所見を認め，薬物性肝障害に合致した．桂枝加竜骨牡蛎湯，辛夷清肺湯による薬物性肝障害の報告はなく，貴重な症例と考えられた．

DOI： 10.11405/nisshoshi.112.1054
Reply to Letter to the Editor by Pujals et al. International journal

65 ( 6 ) 339 - 339 2015.6

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DOI： 10.1111/pin.12307
Recurrence 11 years after complete response to gemcitabine, 5-Fluorouracil, and Cisplatin chemotherapy followed by radiotherapy in a patient with advanced pancreatic cancer: a case report. International journal

Tomoyuki Uchihara, Yo-Ichi Yamashita, Wang Hualin, Kazuki Takeishi, Shinji Itoh, Norihumi Harimoto, Tomoharu Yoshizumi, Shinichi Aishima, Ken Shirabe, Hideo Baba, Yoshihiko Maehara

Anticancer research 35 ( 5 ) 2867 - 71 2015.5

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Correlation of HER2 expression with clinicopathological characteristics and prognosis in resectable gastric cancer. International journal

Hajime Otsu, Eiji Oki, Ayae Ikawa-Yoshida, Hiroyuki Kawano, Koji Ando, Satoshi Ida, Yasue Kimura, Shinichi Aishima, Hiroshi Saeki, Masaru Morita, Shunji Kohnoe, Yoshinao Oda, Yoshihiko Maehara

Anticancer research 35 ( 4 ) 2441 - 6 2015.4

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Long-term outcome of living-donor liver transplantation for combined hepatocellular-cholangiocarcinoma. International journal

Shinji Itoh, Toru Ikegami, Tomoharu Yoshizumi, Huanlin Wang, Kazuki Takeishi, Norifumi Harimoto, Yo-Ichi Yamashita, Hirofumi Kawanaka, Shinichi Aishima, Ken Shirabe, Yoshihiko Maehara

Anticancer research 35 ( 4 ) 2475 - 6 2015.4

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Hepatology: Rare Stevens-Johnson syndrome and vanishing bile duct syndrome induced by acetaminophen, requiring liver transplantation

N. Harimoto, H. Wang, T. Ikegami, K. Takeishi, S. Itoh, Y. I. Yamashita, T. Yoshizumi, S. Aishima, K. Shirabe, Y. Oda, Y. Maehara

Journal of Gastroenterology and Hepatology (Australia) 30 ( 4 ) 656 - 656 2015.4

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DOI： 10.1111/jgh.12849
Granulomatous interstitial pneumonia induced by the intake of rice bran pickles: a rare subtype of pulmonary manifestation associated with food allergy. International journal

Yoshiaki Kinoshita, Atsuhiko Sakamoto, Shinichi Aishima, Kouko Hidaka

BMJ case reports 2015 2015.4

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DOI： 10.1136/bcr-2014-208261
Evaluation of techniques to prevent colorectal anastomotic leakage. International journal

Tetsuo Ikeda, Ryuichi Kumashiro, Eiji Oki, Kenji Taketani, Koji Ando, Shinichi Aishima, Tomohiko Akahoshi, Masaru Morita, Yoshihiko Maehara

The Journal of surgical research 194 ( 2 ) 450 - 457 2015.4

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DOI： 10.1016/j.jss.2014.11.045
Clinical significance of GNAS mutation in intraductal papillary mucinous neoplasm of the pancreas with concomitant pancreatic ductal adenocarcinoma. International journal

Noboru Ideno, Takao Ohtsuka, Taketo Matsunaga, Hideyo Kimura, Yusuke Watanabe, Koji Tamura, Teppei Aso, Shinichi Aishima, Yoshihiro Miyasaka, Kenoki Ohuchida, Junji Ueda, Shunichi Takahata, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

Pancreas 44 ( 2 ) 311 - 20 2015.3

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DOI： 10.1097/MPA.0000000000000258
[α-Fetoprotein-producing tumor].

73 Suppl 3 784 - 7 2015.3

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Primary hepatic tumors with myxoid change: morphologically unique hepatic adenomas and hepatocellular carcinomas. International journal

Safia N Salaria, Rondell P Graham, Shinichi Aishima, Taofic Mounajjed, Matthew M Yeh, Michael S Torbenson

The American journal of surgical pathology 39 ( 3 ) 318 - 24 2015.3

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DOI： 10.1097/PAS.0000000000000382
Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. International journal

Yusuke Mizuuchi, Shinichi Aishima, Kenoki Ohuchida, Koji Shindo, Minoru Fujino, Masami Hattori, Tetsuyuki Miyazaki, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

Laboratory investigation; a journal of technical methods and pathology 95 ( 2 ) 193 - 206 2015.2

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DOI： 10.1038/labinvest.2014.138
Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type.

Shinichi Aishima, Yoshinao Oda

Journal of hepato-biliary-pancreatic sciences 22 ( 2 ) 94 - 100 2015.2

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DOI： 10.1002/jhbp.154
A novel serum marker, glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA(+)-M2BP), for assessing liver fibrosis.

Takeo Toshima, Ken Shirabe, Toru Ikegami, Tomoharu Yoshizumi, Atsushi Kuno, Akira Togayachi, Masanori Gotoh, Hisashi Narimatsu, Masaaki Korenaga, Masashi Mizokami, Akihito Nishie, Shinichi Aishima, Yoshihiko Maehara

Journal of gastroenterology 50 ( 1 ) 76 - 84 2015.1

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DOI： 10.1007/s00535-014-0946-y
Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy.

Yuichiroh Umemoto, Shinji Okano, Yoshihiro Matsumoto, Hidekazu Nakagawara, Rumi Matono, Shohei Yoshiya, Yo-Ichi Yamashita, Tomoharu Yoshizumi, Toru Ikegami, Yuji Soejima, Mamoru Harada, Shinichi Aishima, Yoshinao Oda, Ken Shirabe, Yoshihiko Maehara

Journal of gastroenterology 50 ( 1 ) 65 - 75 2015.1

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DOI： 10.1007/s00535-014-0933-3
Hepatocellular carcinoma: clinical significance of signal heterogeneity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging. International journal

Nobuhiro Fujita, Akihiro Nishie, Yuichiro Kubo, Yoshiki Asayama, Yasuhiro Ushijima, Yukihisa Takayama, Koichiro Moirta, Ken Shirabe, Shinichi Aishima, Hiroshi Honda

European radiology 25 ( 1 ) 211 - 20 2015.1

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DOI： 10.1007/s00330-014-3349-9
Different histological sequelae of immune-mediated graft dysfunction after interferon treatment in transplanted dual grafts from living donors. International journal

Mizuki Ninomiya, Shinichi Aishima, Tomoharu Yoshizumi, Toru Ikegami, Huanlin Wang, Norifumi Harimoto, Shinji Ito, Hideaki Uchiyama, Yuji Soejima, Hirofumi Kawanaka, Ken Shirabe, Yoshihiko Maehara

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20 ( 12 ) 1520 - 2 2014.12

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DOI： 10.1002/lt.23996
Micro RNA-373 is down-regulated in pancreatic cancer and inhibits cancer cell invasion. International journal

Kohei Nakata, Kenoki Ohuchida, Kazuhiro Mizumoto, Shinichi Aishima, Yoshinao Oda, Eishi Nagai, Masao Tanaka

Annals of surgical oncology 21 Suppl 4 ( 4 ) S564-74 - 574 2014.12

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DOI： 10.1245/s10434-014-3676-8
"High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas. International journal

Teppei Aso, Takao Ohtsuka, Taketo Matsunaga, Hideyo Kimura, Yusuke Watanabe, Koji Tamura, Noboru Ideno, Takashi Osoegawa, Shunnichi Takahata, Koji Shindo, Yasuhiro Ushijima, Shinichi Aishima, Yoshinao Oda, Tetsuhide Ito, Kazuhiro Mizumoto, Masao Tanaka

Pancreas 43 ( 8 ) 1239 - 43 2014.11

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DOI： 10.1097/MPA.0000000000000199
Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: pathogenesis and histological characteristics. International journal

Shinichi Aishima, Yuki Tanaka, Yuichiro Kubo, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

Pathology international 64 ( 11 ) 551 - 9 2014.11

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DOI： 10.1111/pin.12209
Gallbladder cancer: Clinical and pathological approach. International journal

Keita Kai, Shinichi Aishima, Kohji Miyazaki

World journal of clinical cases 2 ( 10 ) 515 - 21 2014.10

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DOI： 10.12998/wjcc.v2.i10.515
Pathological manifestation of difference in washout pattern of adrenal hyperplasia on dynamic CT. International journal

Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, Yasuhiro Ushijima, Yukihisa Takayama, Akira Yokomizo, Katsunori Tatsugami, Junichi Inokuchi, Nobuhiro Fujita, Yuichiro Kubo, Shinichi Aishima, Masakazu Hirakawa, Hiroshi Honda

Journal of medical imaging and radiation oncology 58 ( 5 ) 559 - 64 2014.10

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DOI： 10.1111/1754-9485.12211
The apelin-APJ system induces tumor arteriogenesis in hepatocellular carcinoma. International journal

Jun Muto, Ken Shirabe, Tomoharu Yoshizumi, Toru Ikegami, Shinichi Aishima, Kousei Ishigami, Yoshikazu Yonemitsu, Tetsuo Ikeda, Yuji Soejima, Yoshihiko Maehara

Anticancer research 34 ( 10 ) 5313 - 20 2014.10

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Correlation between biological marker expression and fluorine-18 fluorodeoxyglucose uptake in hepatocellular carcinoma. International journal

Yohei Mano, Shinichi Aishima, Yuichiro Kubo, Yuki Tanaka, Takashi Motomura, Takeo Toshima, Ken Shirabe, Shingo Baba, Yoshihiko Maehara, Yoshinao Oda

American journal of clinical pathology 142 ( 3 ) 391 - 7 2014.9

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DOI： 10.1309/AJCPG8AFJ5NRKLLM
Podoplanin expression in the cyst wall correlates with the progression of intraductal papillary mucinous neoplasm. International journal

Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Takao Ohtsuka, Shoji Tokunaga, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

Virchows Archiv : an international journal of pathology 465 ( 3 ) 265 - 73 2014.9

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DOI： 10.1007/s00428-014-1610-x
Pancreatic intraepithelial neoplasia in the background of invasive ductal carcinoma of the pancreas as a prognostic factor. International journal

Yasunori Oda, Shinichi Aishima, Katsuya Morimatsu, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Tetsuyuki Miyazaki, Masao Tanaka, Yoshinao Oda

Histopathology 65 ( 3 ) 389 - 97 2014.9

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DOI： 10.1111/his.12397
Different expression of glucose transporters in the progression of intrahepatic cholangiocarcinoma. International journal

Yuichiro Kubo, Shinichi Aishima, Yuki Tanaka, Koji Shindo, Yusuke Mizuuchi, Koichiro Abe, Ken Shirabe, Yoshihiko Maehara, Hiroshi Honda, Yoshinao Oda

Human pathology 45 ( 8 ) 1610 - 7 2014.8

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DOI： 10.1016/j.humpath.2014.03.008
Significance of accurate human epidermal growth factor receptor-2 (HER2) evaluation as a new biomarker in gastric cancer. International journal

Yasue Kimura, Eiji Oki, Ayae Yoshida, Shinichi Aishima, Yoko Zaitsu, Hajime Ohtsu, Koji Ando, Satoshi Ida, Hiroshi Saeki, Masaru Morita, Tetsuya Kusumoto, Yoshinao Oda, Yoshihiko Maehara

Anticancer research 34 ( 8 ) 4207 - 12 2014.8

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Histological features of precancerous and early cancerous lesions of biliary tract carcinoma.

Shinichi Aishima, Yuichiro Kubo, Yuki Tanaka, Yoshinao Oda

Journal of hepato-biliary-pancreatic sciences 21 ( 7 ) 448 - 52 2014.7

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DOI： 10.1002/jhbp.71
Phase II study of docetaxel and S-1 (DS) as neoadjuvant chemotherapy for clinical stage III resectable gastric cancer. International journal

Eiji Oki, Yasunori Emi, Tetsuya Kusumoto, Yoshihisa Sakaguchi, Manabu Yamamoto, Noriaki Sadanaga, Mototsugu Shimokawa, Takeharu Yamanaka, Hiroshi Saeki, Masaru Morita, Ikuo Takahashi, Naoki Hirabayashi, Kenji Sakai, Hiroyuki Orita, Shinichi Aishima, Yoshihiro Kakeji, Kazuya Yamaguchi, Kazuhiro Yoshida, Hideo Baba, Yoshihiko Maehara

Annals of surgical oncology 21 ( 7 ) 2340 - 6 2014.7

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DOI： 10.1245/s10434-014-3594-9
Peritoneal myofibroblasts at metastatic foci promote dissemination of pancreatic cancer. International journal

Shin Akagawa, Kenoki Ohuchida, Nobuhiro Torata, Masami Hattori, Daiki Eguchi, Kenji Fujiwara, Shingo Kozono, Lin Cui, Naoki Ikenaga, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto, Yoshinao Oda, Masao Tanaka

International journal of oncology 45 ( 1 ) 113 - 20 2014.7

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DOI： 10.3892/ijo.2014.2391
New scoring system for prediction of microvascular invasion in patients with hepatocellular carcinoma. International journal

Ken Shirabe, Takeo Toshima, Koichi Kimura, Yoichi Yamashita, Tetsuo Ikeda, Toru Ikegami, Tomoharu Yoshizumi, Koichiro Abe, Shinichi Aishima, Yoshihiko Maehara

Liver international : official journal of the International Association for the Study of the Liver 34 ( 6 ) 937 - 41 2014.7

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DOI： 10.1111/liv.12459
Analysis of risk factors for recurrence after curative resection of well-differentiated pancreatic neuroendocrine tumors based on the new grading classification.

Kosuke Tsutsumi, Takao Ohtsuka, Minoru Fujino, Hiroshi Nakashima, Shinichi Aishima, Junji Ueda, Shunichi Takahata, Masafumi Nakamura, Yoshinao Oda, Masao Tanaka

Journal of hepato-biliary-pancreatic sciences 21 ( 6 ) 418 - 25 2014.6

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DOI： 10.1002/jhbp.47
Role of tumor-associated macrophages in the angiogenesis of well-differentiated hepatocellular carcinoma: pathological-radiological correlation. International journal

Nobuhiro Fujita, Akihiro Nishie, Shinichi Aishima, Yuichiro Kubo, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Yasuhiro Ushijima, Yukihisa Takayama, Ken Shirabe, Yoshinao Oda, Hiroshi Honda

Oncology reports 31 ( 6 ) 2499 - 505 2014.6

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DOI： 10.3892/or.2014.3138
Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma. International journal

Mikako Osada, Shinichi Aishima, Minako Hirahashi, Nobuyoshi Takizawa, Shunsuke Takahashi, Kazuhiko Nakamura, Masao Tanaka, Yoshihiko Maehara, Ryoichi Takayanagi, Yoshinao Oda

Human pathology 45 ( 6 ) 1243 - 50 2014.6

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DOI： 10.1016/j.humpath.2014.02.003
Chronic immune-mediated reaction syndrome as the cause of late graft mortality in living-donor liver transplantation for primary biliary cirrhosis

N. Harimoto, T. Ikegami, H. Nakagawara, Y. I. Yamashita, T. Yoshizumi, H. Uchiyama, Y. Soejima, T. Ikeda, K. Shirabe, S. Aishima, Y. Oda, Y. Maehara

Transplantation Proceedings 46 ( 5 ) 1438 - 1443 2014.6

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DOI： 10.1016/j.transproceed.2014.02.021
Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer.

Eriko Tokunaga, Yuichiro Nakashima, Nami Yamashita, Yuichi Hisamatsu, Satoko Okada, Sayuri Akiyoshi, Shinichi Aishima, Hiroyuki Kitao, Masaru Morita, Yoshihiko Maehara

Breast cancer (Tokyo, Japan) 21 ( 3 ) 341 - 9 2014.5

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DOI： 10.1007/s12282-012-0398-2
A case of invasive micropapillary carcinoma of the breast involving extensive lymph node metastasis. International journal

Kenji Taketani, Eriko Tokunaga, Nami Yamashita, Kimihiro Tanaka, Yoko Zaitsu, Sayuri Akiyoshi, Satoko Okada, Shinichi Aishima, Masaru Morita, Yoshihiko Maehara

World journal of surgical oncology 12 ( 1 ) 84 - 84 2014.4

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DOI： 10.1186/1477-7819-12-84
Strategies to treat interferon-induced graft dysfunction after living donor liver transplantation for hepatitis C. International journal

Toru Ikegami, Huanlin Wang, Tomoharu Yoshizumi, Takeo Toshima, Shinichi Aishima, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Shinji Shimoda, Ken Shirabe, Yoshihiko Maehara

Hepatology international 8 ( 2 ) 285 - 92 2014.4

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DOI： 10.1007/s12072-013-9496-2
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients. International journal

Minako Hirahashi, Yutaka Koga, Reiko Kumagai, Shinichi Aishima, Kenichi Taguchi, Yoshinao Oda

Pathology international 64 ( 4 ) 155 - 63 2014.4

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DOI： 10.1111/pin.12152
Elevated expression level of microRNA-196a is predictive of intestinal-type intraductal papillary mucinous neoplasm of the pancreas. International journal

Teppei Aso, Takao Ohtsuka, Koji Tamura, Noboru Ideno, Hiroshi Kono, Yosuke Nagayoshi, Kennoki Ohuchida, Junji Ueda, Shunnichi Takahata, Koji Shindo, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

Pancreas 43 ( 3 ) 361 - 6 2014.4

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DOI： 10.1097/MPA.0000000000000042
Key endoscopic ultrasound features of pancreatic ductal adenocarcinoma smaller than 20 mm. International journal

Akira Aso, Eikichi Ihara, Takashi Osoegawa, Kazuhiko Nakamura, Soichi Itaba, Hisato Igarashi, Tetsuhide Ito, Shinichi Aishima, Yoshinao Oda, Masao Tanaka, Ryoichi Takayanagi

Scandinavian journal of gastroenterology 49 ( 3 ) 332 - 8 2014.3

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DOI： 10.3109/00365521.2013.878745
Follicular pancreatitis, report of a case clinically mimicking pancreatic cancer and literature review. International journal

Yusuke Mizuuchi, Shinichi Aishima, Masami Hattori, Yasuhiro Ushijima, Akira Aso, Shunichi Takahata, Takao Ohtsuka, Junji Ueda, Masao Tanaka, Yoshinao Oda

Pathology, research and practice 210 ( 2 ) 118 - 22 2014.2

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DOI： 10.1016/j.prp.2013.09.005
Treatment strategy for main duct intraductal papillary mucinous neoplasms of the pancreas based on the assessment of recurrence in the remnant pancreas after resection: a retrospective review. International journal

Koji Tamura, Takao Ohtsuka, Noboru Ideno, Teppei Aso, Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Shunichi Takahata, Yasuhiro Ushijima, Tetsuhide Ito, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

Annals of surgery 259 ( 2 ) 360 - 8 2014.2

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DOI： 10.1097/SLA.0b013e3182a690ff
Expression of glucagon-like Peptide 1 receptor and its effects on biologic behavior in pancreatic neuroendocrine tumors. International journal

Ana Ines Cases, Takao Ohtsuka, Minoru Fujino, Noboru Ideno, Shingo Kozono, Ming Zhao, Kenoki Ohuchida, Shinichi Aishima, Masatoshi Nomura, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

Pancreas 43 ( 1 ) 1 - 6 2014.1

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DOI： 10.1097/MPA.0b013e3182a71537
Tissue tablet method: an efficient tissue banking procedure applicable to both molecular analysis and frozen tissue microarray. International journal

Nobuhiro Torata, Kenoki Ohuchida, Shin Akagawa, Lin Cui, Shingo Kozono, Kazuhiro Mizumoto, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

Human pathology 45 ( 1 ) 143 - 52 2014.1

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DOI： 10.1016/j.humpath.2013.08.013
Spontaneous massive necrosis of hepatocellular carcinoma with narrowing and occlusion of the arteries and portal veins. International journal

Takahiro Tomino, Yo-Ichi Yamashita, Tomohiro Iguchi, Shinji Itoh, Mizuki Ninomiya, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Hirofumi Kawanaka, Tetsuo Ikeda, Shinichi Aishima, Ken Shirabe, Yoshihiko Maehara

Case reports in gastroenterology 8 ( 1 ) 148 - 55 2014.1

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DOI： 10.1159/000362440
Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia.

Yasunori Sato, Motoko Sasaki, Kenichi Harada, Shinichi Aishima, Toshio Fukusato, Hidenori Ojima, Yae Kanai, Masayoshi Kage, Yasuni Nakanuma, Hirohito Tsubouchi

Journal of gastroenterology 49 ( 1 ) 64 - 72 2014.1

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DOI： 10.1007/s00535-013-0810-5
Intraoperative irrigation cytology of the remnant pancreas to detect remnant distinct pancreatic ductal adenocarcinoma in patients with intraductal papillary mucinous neoplasm undergoing partial pancreatectomy. International journal

Yasuhisa Mori, Takao Ohtsuka, Koji Tamura, Noboru Ideno, Teppei Aso, Hiroshi Kono, Yosuke Nagayoshi, Junji Ueda, Shunichi Takahata, Shinichi Aishima, Fumihiko Ookubo, Yoshinao Oda, Masao Tanaka

Surgery 155 ( 1 ) 67 - 73 2014.1

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DOI： 10.1016/j.surg.2013.06.059
Differential impact of the expression of the androgen receptor by age in estrogen receptor-positive breast cancer. International journal

Eriko Tokunaga, Yuichi Hisamatsu, Kenji Taketani, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Kimihiro Tanaka, Hiroshi Saeki, Eiji Oki, Shinichi Aishima, Yoshinao Oda, Masaru Morita, Yoshihiko Maehara

Cancer medicine 2 ( 6 ) 763 - 73 2013.12

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DOI： 10.1002/cam4.138
mFOLFOX6療法後に発症した門脈圧亢進症の1例

緒方大聡, 具嶋敏文, 丸岡新子, 高崎智子, 田中吏佐, 松浦隆志, 相島慎一, 高橋和弘

日本消化器病学会雑誌 110 ( 12 ) 2119 - 26 2013.12

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症例は46歳男性．S状結腸癌肝転移の診断でS状結腸切除術，肝部分切除術，胆嚢切除術を施行された．術後化学療法としてmFOLFOX6療法を施行された頃から血小板減少と脾腫が出現し，3年後にF3の食道胃静脈瘤を認めた．肝生検組織では，大腸癌手術時の摘出肝と比して類洞の拡張に加え門脈が狭小化して不明瞭となっていた．Oxaliplatinは非肝硬変性の門脈圧亢進症をきたすことがあり，留意すべきである．

DOI： 10.11405/nisshoshi.110.2119, 10.2957/kanzo.61.358_references_DOI_UKRW5UlBD1NDFXslFg78J5YToE0, 10.5833/jjgs.2017.0194_references_DOI_UKRW5UlBD1NDFXslFg78J5YToE0
Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas. International journal

Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Kenji Fujiwara, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

Molecular cancer 12 ( 1 ) 168 - 168 2013.12

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DOI： 10.1186/1476-4598-12-168
Decreased roundabout 1 expression promotes development of intrahepatic cholangiocarcinoma. International journal

Yohei Mano, Shinichi Aishima, Takasuke Fukuhara, Yuki Tanaka, Yuichiro Kubo, Takashi Motomura, Takeo Toshima, Tomohiro Iguchi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

Human pathology 44 ( 11 ) 2419 - 26 2013.11

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DOI： 10.1016/j.humpath.2013.03.022
Migratory activity of CD105+ pancreatic cancer cells is strongly enhanced by pancreatic stellate cells. International journal

Kenji Fujiwara, Kenoki Ohuchida, Takao Ohtsuka, Kazuhiro Mizumoto, Koji Shindo, Naoki Ikenaga, Lin Cui, Shunichi Takahata, Shinichi Aishima, Masao Tanaka

Pancreas 42 ( 8 ) 1283 - 90 2013.11

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DOI： 10.1097/MPA.0b013e318293e7bd
A case of fatal intrahepatic cholestasis with primary AL amyloidosis: is early diagnosis possible?

Shinichiro Takao, Kosuke Tanaka, Masayuki Miyazaki, Masatake Tanaka, Tomoko Ohashi, Masaki Kato, Kazuhiro Kotoh, Shinichi Aishima, Ryoichi Takayanagi

Clinical journal of gastroenterology 6 ( 5 ) 386 - 9 2013.10

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DOI： 10.1007/s12328-013-0406-x
Insulin-like growth factor II messenger RNA-binding protein-3 is a valuable diagnostic and prognostic marker of intraductal papillary mucinous neoplasm. International journal

Katsuya Morimatsu, Shinichi Aishima, Hidetaka Yamamoto, Akifumi Hayashi, Kohei Nakata, Yasunori Oda, Koji Shindo, Minoru Fujino, Masao Tanaka, Yoshinao Oda

Human pathology 44 ( 9 ) 1714 - 21 2013.9

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DOI： 10.1016/j.humpath.2012.12.020
S-1/Docetaxel併用療法にて同時性肝転移が病理学的完全奏効となった胃癌の1例

北原大和, 沖英次, 佐伯浩司, 安藤幸滋, 調憲, 鴻江俊治, 相島慎一, 掛地吉弘, 前原喜彦

癌と化学療法 40 ( 8 ) 1093 - 7 2013.8

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Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis. International journal

Yohei Mano, Ken Shirabe, Yo-Ichi Yamashita, Norifumi Harimoto, Eiji Tsujita, Kazuki Takeishi, Shinichi Aishima, Toru Ikegami, Tomoharu Yoshizumi, Takeharu Yamanaka, Yoshihiko Maehara

Annals of surgery 258 ( 2 ) 301 - 5 2013.8

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DOI： 10.1097/SLA.0b013e318297ad6b
Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas. International journal

Yasunori Oda, Shinichi Aishima, Katsuya Morimatsu, Akifumi Hayashi, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Masao Tanaka, Yoshinao Oda

Human pathology 44 ( 8 ) 1487 - 98 2013.8

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DOI： 10.1016/j.humpath.2012.12.001
Distinctive histopathologic findings of pancreatic hamartomas suggesting their "hamartomatous" nature: a study of 9 cases. International journal

Hiroshi Yamaguchi, Shinichi Aishima, Yoshinao Oda, Hiroki Mizukami, Takuma Tajiri, Sohsuke Yamada, Takashi Tasaki, Keisuke Yamakita, Koji Imai, Fumi Kawakami, Shigeo Hara, Keiji Hanada, Tomohiro Iiboshi, Toshikatsu Fukuda, Hiroshi Imai, Hiroyuki Inoue, Tatsuya Nagakawa, Shunji Muraoka, Toru Furukawa, Michio Shimizu

The American journal of surgical pathology 37 ( 7 ) 1006 - 13 2013.7

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DOI： 10.1097/PAS.0b013e318283ce4c
Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype. International journal

Noboru Ideno, Takao Ohtsuka, Hiroshi Kono, Kenji Fujiwara, Yasunori Oda, Shinichi Aishima, Tetsuhide Ito, Kousei Ishigami, Shoji Tokunaga, Kenoki Ohuchida, Shunichi Takahata, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

Annals of surgery 258 ( 1 ) 141 - 51 2013.7

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DOI： 10.1097/SLA.0b013e31828cd008
High expression of microRNA-155 is associated with the aggressive malignant behavior of gallbladder carcinoma. International journal

Hiroshi Kono, Masafumi Nakamura, Takao Ohtsuka, Yosuke Nagayoshi, Yasuhisa Mori, Shunichi Takahata, Shinichi Aishima, Masao Tanaka

Oncology reports 30 ( 1 ) 17 - 24 2013.7

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DOI： 10.3892/or.2013.2443
Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma. International journal

Shinichi Aishima, Yohei Mano, Yuki Tanaka, Yuichiro Kubo, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

Human pathology 44 ( 6 ) 1031 - 7 2013.6

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DOI： 10.1016/j.humpath.2012.09.004
Early extensive viremia, but not rs8099917 genotype, is the only predictor for cholestatic hepatitis C after living-donor liver transplantation. International journal

Toru Ikegami, Ken Shirabe, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Masaki Kato, Shinji Shimoda, Shinichi Aishima, Yuji Soejima, Tomoharu Yoshizumi, Yoshihiko Maehara

Hepatology research : the official journal of the Japan Society of Hepatology 43 ( 6 ) 621 - 9 2013.6

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DOI： 10.1111/hepr.12003
Vimentin as a poor prognostic factor for triple-negative breast cancer. International journal

Nami Yamashita, Eriko Tokunaga, Hiroyuki Kitao, Yuichi Hisamatsu, Kenji Taketani, Sayuri Akiyoshi, Satoko Okada, Shinichi Aishima, Masaru Morita, Yoshihiko Maehara

Journal of cancer research and clinical oncology 139 ( 5 ) 739 - 46 2013.5

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DOI： 10.1007/s00432-013-1376-6
Clinical usefulness of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography for patients with primary liver cancer with special reference to rare histological types, hepatocellular carcinoma with sarcomatous change and combined hepatocellular and cholangiocarcinoma. International journal

Hideki Ijichi, Ken Shirabe, Akinobu Taketomi, Tomoharu Yoshizumi, Toru Ikegami, Youhei Mano, Shinichi Aishima, Koichiro Abe, Hiroshi Honda, Yoshihiko Maehara

Hepatology research : the official journal of the Japan Society of Hepatology 43 ( 5 ) 481 - 7 2013.5

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DOI： 10.1111/j.1872-034X.2012.01107.x
Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case.

Mikihiro Kohno, Ken Shirabe, Yohei Mano, Jun Muto, Takashi Motomura, Kazuki Takeishi, Takeo Toshima, Masanori Yoshimatsu, Hideki Ijichi, Noboru Harada, Shinichi Aishima, Hideaki Uchiyama, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara

Surgery today 43 ( 4 ) 439 - 45 2013.4

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DOI： 10.1007/s00595-012-0202-0
Kindlin-1 expression is involved in migration and invasion of pancreatic cancer. International journal

Prawej Mahawithitwong, Kenoki Ohuchida, Naoki Ikenaga, Hayato Fujita, Ming Zhao, Shingo Kozono, Koji Shindo, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto, Masao Tanaka

International journal of oncology 42 ( 4 ) 1360 - 6 2013.4

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DOI： 10.3892/ijo.2013.1838
Role of endoscopic retrograde pancreatography for early detection of pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm of the pancreas.

Takao Ohtsuka, Noboru Ideno, Teppei Aso, Yosuke Nagayoshi, Hiroshi Kono, Yasuhisa Mori, Shunichi Takahata, Yasunori Oda, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

Journal of hepato-biliary-pancreatic sciences 20 ( 3 ) 356 - 61 2013.3

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DOI： 10.1007/s00534-012-0541-7
Ezrin expression and its phosphorylation in gastric carcinoma with lymphoid stroma and Epstein-Barr virus infection. International journal

Taro Tobo, Minako Hirahashi, Takashi Yao, Shinichi Aishima, Yoshinao Oda

Molecular and clinical oncology 1 ( 2 ) 220 - 224 2013.3

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Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC. International journal

Masatake Tanaka, Yuko Masaki, Kosuke Tanaka, Masayuki Miyazaki, Masaki Kato, Rie Sugimoto, Kazuhiko Nakamura, Shinichi Aishima, Ken Shirabe, Makoto Nakamuta, Munechika Enjoji, Kazuhiro Kotoh, Ryoichi Takayanagi

Molecular medicine reports 7 ( 2 ) 365 - 70 2013.2

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DOI： 10.3892/mmr.2012.1201
A morphological study of the removed livers from patients receiving living donor liver transplantation for adult biliary atresia. International journal

Toshiharu Matsuura, Kenichi Kohashi, Yusuke Yanagi, Isamu Saeki, Makoto Hayashida, Shinichi Aishima, Yoshinao Oda, Tomoaki Taguchi

Pediatric surgery international 28 ( 12 ) 1171 - 5 2012.12

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DOI： 10.1007/s00383-012-3183-6
Management strategy for multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas. International journal

Yasuhisa Mori, Takao Ohtsuka, Hiroshi Kono, Noboru Ideno, Teppei Aso, Yosuke Nagayoshi, Shunichi Takahata, Masafumi Nakamura, Kousei Ishigami, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

Pancreas 41 ( 7 ) 1008 - 12 2012.10

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DOI： 10.1097/MPA.0b013e31824b22c6
The risk of lymph node metastasis in mucosal gastric carcinoma: especially for a mixture of differentiated and undifferentiated adenocarcinoma. International journal

Kohei Nakata, Eishi Nagai, Yoshihiro Miyasaka, Kenoki Ohuchida, Takao Ohtsuka, Hiroki Toma, Minako Hirahashi, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

Hepato-gastroenterology 59 ( 118 ) 1855 - 8 2012.9

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DOI： 10.5754/hge10130
Diagnostic significance of a dilated orifice of the duodenal papilla in intraductal papillary mucinous neoplasm of the pancreas. International journal

Teppei Aso, Takao Ohtsuka, Noboru Ideno, Hiroshi Kono, Yosuke Nagayoshi, Yasuhisa Mori, Kennoki Ohuchida, Junji Ueda, Shunnichi Takahata, Katsuya Morimatsu, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Kazuhiro Mizumoto, Masao Tanaka

Gastrointestinal endoscopy 76 ( 2 ) 313 - 20 2012.8

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DOI： 10.1016/j.gie.2012.03.682
Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas. International journal

Takao Ohtsuka, Hiroshi Kono, Reiko Tanabe, Yosuke Nagayoshi, Yasuhisa Mori, Yoshihiko Sadakari, Shunichi Takahata, Yasunori Oda, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

American journal of surgery 204 ( 1 ) 44 - 8 2012.7

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DOI： 10.1016/j.amjsurg.2011.04.007
Primary graft dysfunction after living donor liver transplantation is characterized by delayed functional hyperbilirubinemia

Toru Ikegami, K. Shirabe, T. Yoshizumi, S. Aishima, Y. A. Taketomi, Y. Soejima, H. Uchiyama, H. Kayashima, T. Toshima, Y. Maehara

American Journal of Transplantation 12 ( 7 ) 1886 - 1897 2012.7

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DOI： 10.1111/j.1600-6143.2012.04052.x
Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production.

Kosuke Tsutsumi, Takao Ohtsuka, Yasuhisa Mori, Minoru Fujino, Takaharu Yasui, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Tetsuhide Ito, Masao Tanaka

Journal of gastroenterology 47 ( 6 ) 678 - 85 2012.6

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DOI： 10.1007/s00535-012-0540-0
Predictors for microinvasion of small hepatocellular carcinoma ≤ 2 cm. International journal

19 ( 6 ) 2027 - 34 2012.6

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BACKGROUND: Hepatocellular carcinoma (HCC) ≤ 2 cm in diameter is considered to have a low potential for malignancy. METHODS: A retrospective review was undertaken of 149 patients with primary solitary HCC ≤ 2 cm who underwent initial hepatic resection between 1994 and 2010. The independent predictors of the microinvasion (MI) such as portal venous, hepatic vein, or bile duct infiltration and/or intrahepatic metastasis were identified by multivariate analysis. Prognosis of patients with HCC ≤ 2 cm accompanied by MI was compared to that of patients with HCC ≤ 2 cm without MI. RESULTS: Forty-three patients with HCC ≤ 2 cm had MI in patients (28.9%). Three independent predictors of the MI were revealed: invasive gross type (simple nodular type with extranodular growth or confluent multinodular type), des-γ-carboxy prothrombin (DCP) >100 mAU/ml, and poorly differentiated. Disease-free survival rates of patients with HCC ≤ 2 cm with MI (3 year 44%) were significantly worse than those for HCC ≤ 2 cm without MI (3 year 72%). This disadvantage of disease-free survival rate of patients with HCC ≤ 2 cm with MI could be dissolved by hepatic resection with a wide tumor margin of ≥ 5 mm (P = 0.04). CONCLUSIONS: Even in cases of HCC ≤ 2 cm, patients who are suspected of having invasive gross type tumors in preoperative imaging diagnosis or who have a high DCP level (>100 mAU/ml) are at risk for MI. Therefore, in such patients, hepatic resection with a wide tumor margin should be recommended.

DOI： 10.1245/s10434-011-2195-0
Enhancement pattern analysis of hypervascular hepatocellular carcinoma on dynamic MR imaging with histopathological correlation: validity of portal phase imaging for predicting tumor grade. International journal

Daisuke Okamoto, Kengo Yoshimitsu, Akihiro Nishie, Tsuyoshi Tajima, Yoshiki Asayama, Kousei Ishigami, Masakazu Hirakawa, Yasuhiro Ushijima, Daisuke Kakihara, Tomohiro Nakayama, Yunosuke Nishihara, Shinichi Aishima, Akinobu Taketomi, Junji Kishimoto, Hiroshi Honda

European journal of radiology 81 ( 6 ) 1116 - 21 2012.6

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DOI： 10.1016/j.ejrad.2011.02.056
Impact of FOXA1 expression on the prognosis of patients with hormone receptor-positive breast cancer. International journal

Yuichi Hisamatsu, Eriko Tokunaga, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Yuichiro Nakashima, Shinichi Aishima, Masaru Morita, Yoshihiro Kakeji, Yoshihiko Maehara

Annals of surgical oncology 19 ( 4 ) 1145 - 52 2012.4

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DOI： 10.1245/s10434-011-2094-4
An increase in the number of predictive factors augments the likelihood of malignancy in branch duct intraductal papillary mucinous neoplasm of the pancreas. International journal

Takao Ohtsuka, Hiroshi Kono, Yosuke Nagayoshi, Yasuhisa Mori, Kosuke Tsutsumi, Yoshihiko Sadakari, Shunichi Takahata, Katsuya Morimatsu, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

Surgery 151 ( 1 ) 76 - 83 2012.1

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DOI： 10.1016/j.surg.2011.07.009
Total resection of the right hepatic vein drainage area with the aid of three-dimensional computed tomography.

Akinobu Taketomi, Kazuki Takeishi, Yohei Mano, Takeo Toshima, Takashi Motomura, Shinichi Aishima, Hideaki Uchiyama, Tomoharu Yoshizumi, Ken Shirabe, Yoshihiko Maehara

Surgery today 42 ( 1 ) 46 - 51 2012.1

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DOI： 10.1007/s00595-011-0021-8
Uptake of Gd-EOB-DTPA by hepatocellular carcinoma: radiologic-pathologic correlation with special reference to bile production. International journal

Yoshiki Asayama, Tsuyoshi Tajima, Akihiro Nishie, Kousei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, Daisuke Okamoto, Nobuhiro Fujita, Shinichi Aishima, Ken Shirabe, Hiroshi Honda

European journal of radiology 80 ( 3 ) e243-8 2011.12

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DOI： 10.1016/j.ejrad.2010.10.032
Nuclear atypia grading score is a useful prognostic factor in papillary gastric adenocarcinoma. International journal

Yuichiro Nakashima, Takashi Yao, Minako Hirahashi, Shinichi Aishima, Yoshihiro Kakeji, Yoshihiko Maehara, Masazumi Tsuneyoshi

Histopathology 59 ( 5 ) 841 - 9 2011.11

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DOI： 10.1111/j.1365-2559.2011.04035.x
Histological and immunohistological findings in biliary intraepithelial neoplasia arising from a background of chronic biliary disease compared with liver cirrhosis of non-biliary aetiology. International journal

Shinichi Aishima, Tomohiro Iguchi, Nobuhiro Fujita, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi, Yoshinao Oda

Histopathology 59 ( 5 ) 867 - 75 2011.11

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DOI： 10.1111/j.1365-2559.2011.04011.x
MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis. International journal

Kohei Nakata, Kenoki Ohuchida, Kazuhiro Mizumoto, Tadashi Kayashima, Naoki Ikenaga, Hiroshi Sakai, Cui Lin, Hayato Fujita, Takao Otsuka, Shinichi Aishima, Eishi Nagai, Yoshinao Oda, Masao Tanaka

Surgery 150 ( 5 ) 916 - 22 2011.11

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DOI： 10.1016/j.surg.2011.06.017
広範微小肺腫瘍塞栓によって呼吸不全を来たした肝細胞癌患者の一例

田中紘介, 中舎晃男, 宮崎将之, 高尾信一郎, 樋口野日斗, 田中正剛, 田中ゆき, 加藤正樹, 古藤和浩, 髙栁涼一, 相島慎一

福岡醫學雜誌 102 ( 10 ) 298 - 302 2011.10

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肝細胞癌の肝外転移臓器として，肺は最も頻度の高い臓器である．CT やMR などの画像検査機器の発達により，肺転移巣の同定は容易となり，その診断に苦慮することは希である．また，肝細胞癌からの肺転移は高頻度であるにもかかわらず，呼吸不全に至る症例は少なく，多くの場合，肺転移巣が拡大して呼吸機能に影響を与えるようになる前に，原発の肝病変が進行して，肝不全に至る．今回我々は，肝細胞癌の経過観察中に，原因不明の呼吸不全が急速に進行した症例を経験した．入院時の画像検査で，肺の腫瘍性病変などの呼吸不全を来たす所見を認めず，酸素化が障害されている原因が不明であったが，死後の肺組織検査により，広範な微小腫瘍塞栓が認められた．肺の腫瘍塞栓によって，急速な呼吸不全を来たす病態として，Pulmonary tumor thrombotic microangiopathy（PTTM）があるが，本症例の病理所見では，PTTM は否定的であった．本症例の呼吸不全に関して若干の文献的考察を加えて報告する．

DOI： 10.15017/20445
Cystic tumors of the liver: on the problems of diagnostic criteria. International journal

Yohei Mano, Shinichi Aishima, Nobuhiro Fujita, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

Pathology, research and practice 207 ( 10 ) 659 - 63 2011.10

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DOI： 10.1016/j.prp.2011.07.006
Histologic classification of microscopic portal venous invasion to predict prognosis in hepatocellular carcinoma. International journal

Nobuhiro Fujita, Shinichi Aishima, Tomohiro Iguchi, Yohei Mano, Akinobu Taketomi, Ken Shirabe, Hiroshi Honda, Masazumi Tsuneyoshi, Yoshinao Oda

Human pathology 42 ( 10 ) 1531 - 8 2011.10

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DOI： 10.1016/j.humpath.2010.12.016
Outcomes of hepatic resection for huge hepatocellular carcinoma (≥ 10 cm in diameter). International journal

104 ( 3 ) 292 - 8 2011.9

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BACKGROUND: The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC) ≥ 10 cm. METHODS: Between 1995 and 2007, fifty-three patients with HCC ≥ 10 cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n = 12). Surgical results for HCC ≥ 10 cm were compared to those of patients with HCC < 10 cm (n = 412). The independent poor prognostic factors of the patients with HCC ≥ 10 cm were identified. RESULTS: Overall survival was significantly better in patients with hepatic resection for HCC ≥ 10 cm than in those with non-surgical treatment (P < 0.01). Survival rates of patients with hepatic resection for HCC ≥ 10 cm were 35% at 5 years. Morbidity and mortality rate were statistically equal. The independent poor prognostic factors of patients with hepatic resection for HCC ≥ 10 cm were revealed: T4 status, macroscopic tumor thrombus in portal vein (VP+), and the use of intra-operative transfusion. CONCLUSION: Hepatic resections for HCC ≥ 10 cm are safe and efficacious. Minimizing intra-operative blood loss and the establishment of an effective systemic treatment for patients with HCC ≥ 10 cm in T4 appear to be critical.

DOI： 10.1002/jso.21931
Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis. International journal

Kohei Nakata, Kenoki Ohuchida, Shinichi Aishima, Yoshihiko Sadakari, Tadashi Kayashima, Yoshihiro Miyasaka, Eishi Nagai, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi, Yoshinao Oda

Pancreas 40 ( 4 ) 581 - 7 2011.5

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DOI： 10.1097/MPA.0b013e318214fa86
Significance of dysadherin and E-cadherin expression in differentiated-type gastric carcinoma with submucosal invasion. International journal

Yoshitomo Maehata, Minako Hirahashi, Shinichi Aishima, Junji Kishimoto, Setsuo Hirohashi, Takashi Yao, Hiroshi Takashima, Masazumi Tsuneyoshi, Yoshinao Oda

Human pathology 42 ( 4 ) 558 - 67 2011.4

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DOI： 10.1016/j.humpath.2010.08.016
Different roles of S100P overexpression in intrahepatic cholangiocarcinoma: carcinogenesis of perihilar type and aggressive behavior of peripheral type. International journal

Shinichi Aishima, Nobuhiro Fujita, Yohei Mano, Yuichiro Kubo, Yuki Tanaka, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

The American journal of surgical pathology 35 ( 4 ) 590 - 8 2011.4

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DOI： 10.1097/PAS.0b013e31820ffdf1
Prognostic significance of preoperative imaging in recipients of living donor liver transplantation for hepatocellular carcinoma. International journal

Keishi Sugimachi, Ken Shirabe, Akinobu Taketomi, Yuji Soejima, Tomohiro Iguchi, Kazuki Takeishi, Takeo Toshima, Shinichi Aishima, Tsuyoshi Tajima, Yoshihiko Maehara

Transplantation 91 ( 5 ) 570 - 4 2011.3

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DOI： 10.1097/TP.0b013e318208134e
Prognostic importance of the gross classification of hepatocellular carcinoma in living donor-related liver transplantation

K. Shirabe, S. Aishima, A. Taketomi, Y. Soejima, H. Uchiyama, H. Kayashima, M. Ninomiya, Y. Mano, Y. Maehara

British Journal of Surgery 98 ( 2 ) 261 - 267 2011.2

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DOI： 10.1002/bjs.7311
Performance of radiological methods in diagnosing hepatocellular carcinoma preoperatively in a recipient of living related liver transplantation: comparison with step section histopathology.

Masakazu Hirakawa, Kengo Yoshimitsu, Hiroyuki Irie, Tsuyoshi Tajima, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Akinobu Taketomi, Shin-ichi Aishima, Hiroshi Honda

Japanese journal of radiology 29 ( 2 ) 129 - 37 2011.2

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DOI： 10.1007/s11604-010-0528-8
Pseudo-Meigs' syndrome associated with breast cancer metastasis to both ovaries: Report of a case.

Naonori Kawakubo, Masayuki Okido, Risa Tanaka, Kenji Mitsugi, Masao Fukuhara, Shinichi Aishima, Masato Kato, Hitoshi Ichimiya

Surgery today 40 ( 12 ) 1148 - 51 2010.12

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DOI： 10.1007/s00595-009-4187-2
Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type. International journal

24 ( 6 ) 1569 - 76 2010.12

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Ovarian mucinous neoplasms of gastro-intestinal type (GI-type) are known to be a heterogeneous tumor composed of benign, borderline and non-invasive and invasive malignant lesions. The presence of infiltrative invasion is also known to be an important prognostic factor of this neoplasm. Laminin γ 2 chain, known to stimulate tumor cell invasion and migration, has not been sufficiently investigated in ovarian mucinous neoplasms. The purpose of this study was thus to clarify the role of laminin γ 2 in ovarian mucinous neoplasms of GI-type. We selected each morphological phase of tumor development from 61 cases of mucinous neoplasms of the GI-type: 55 adenoma lesions, 60 borderline lesions, 20 microinvasive lesions, 17 intraepithelial carcinoma lesions, 38 expansile invasive carcinoma lesions, 19 infiltrative invasive carcinoma lesions and 5 mural nodules lesions; and evaluated the localization of laminin γ 2 in the lesions using immunohistochemical method. The staining pattern was classified into i) basement membranous (BM), ii) cytoplasmic (CYT) and iii) stromal (S) pattern. The BM pattern was characteristic in adenoma, borderline, and interaepithelial and expansile invasive carcinoma lesions. The CYT and S patterns were characteristic in infiltrative invasive lesions. The staining pattern of mural nodules was similar to that of infiltrative invasion. The infiltrative invasion of GI-type ovarian mucinous neoplasms may be promoted by cytoplasmic and/or stromal expression of laminin γ 2 chain.

DOI： 10.3892/or-00001019
Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation. International journal

Akifumi Hayashi, Shinichi Aishima, Yoshihiro Miyasaka, Kohei Nakata, Katsuya Morimatsu, Yasunori Oda, Eishi Nagai, Yoshinao Oda, Masao Tanaka, Masazumi Tsuneyoshi

Human pathology 41 ( 11 ) 1507 - 15 2010.11

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DOI： 10.1016/j.humpath.2010.02.019
Predictors of extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma. International journal

Akinobu Taketomi, Takeo Toshima, Dai Kitagawa, Takashi Motomura, Kazuki Takeishi, Yohei Mano, Hiroto Kayashima, Keishi Sugimachi, Shinichi Aishima, Yoichi Yamashita, Toru Ikegami, Tomonobu Gion, Hideaki Uchiyama, Yuji Soejima, Takashi Maeda, Ken Shirabe, Yoshihiko Maehara

Annals of surgical oncology 17 ( 10 ) 2740 - 6 2010.10

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DOI： 10.1245/s10434-010-1076-2
抗核抗体高値が持続し短期間に無菌性髄膜炎を反復した亜急性壊死性リンパ節炎の１例

山下泰治, 柴田憲一, 長野祐久, 相島慎一, 由村健夫

臨床神経学 50 ( 10 ) 728 - 31 2010.10

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症例は35歳女性である．母に関節リウマチ，妹にシェーグレン症候群がある．1年半の間にリンパ節腫張にひき続く無菌性髄膜炎を3回くりかえした．3回目で頸部リンパ節生検をおこない亜急性壊死性リンパ節炎の所見をえた．非ステロイド系消炎鎮痛薬に対する反応は不良であったが，ステロイド投与後に発熱，頭痛，リンパ節腫張はすみやかに改善した．初回入院時から抗核抗体，抗SS-A抗体陽性は持続しており，とくに抗核抗体は再発の度に抗体価が上昇した．亜急性壊死性リンパ節炎は一般的に数カ月以内に自然治癒する予後良好な疾患で，自己抗体の出現も一過性が多い．本例のように無菌性髄膜炎をくりかえすばあいには，自己免疫異常の持続が一因と考えられる．

DOI： 10.5692/clinicalneurol.50.728, 10.2169/internalmedicine.6494-20_references_DOI_AwNa6llXZ9j97b8W8s8agGc86kC
p62+ Hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease. International journal

Shinichi Aishima, Nobuhiro Fujita, Yohei Mano, Tomohiro Iguchi, Akinobu Taketomi, Yoshihiko Maehara, Yoshinao Oda, Masazumi Tsuneyoshi

American journal of clinical pathology 134 ( 3 ) 457 - 65 2010.9

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DOI： 10.1309/AJCP53YVVJCNDZIR
Imaging of cholangiolocellular carcinoma of the liver. International journal

Yoshiki Asayama, Tsuyoshi Tajima, Daisuke Okamoto, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Daisuke Kakihara, Shinichi Aishima, Akinobu Taketomi, Hiroshi Honda

European journal of radiology 75 ( 1 ) e120-5 2010.7

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DOI： 10.1016/j.ejrad.2009.09.010
Clinicopathological prognostic factors after hepatectomy for patients with mass-forming type intrahepatic cholangiocarcinoma: relevance of the lymphatic invasion index. International journal

Ken Shirabe, Yohei Mano, Akinobu Taketomi, Yuji Soejima, Hideaki Uchiyama, Shinichi Aishima, Hiroto Kayashima, Mizuki Ninomiya, Yoshihiko Maehara

Annals of surgical oncology 17 ( 7 ) 1816 - 22 2010.7

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DOI： 10.1245/s10434-010-0929-z
Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinoma. International journal

Akifumi Hayashi, Shinichi Aishima, Takahiro Inoue, Kohei Nakata, Katsuya Morimatsu, Eishi Nagai, Yoshinao Oda, Masao Tanaka, Masazumi Tsuneyoshi

Human pathology 41 ( 6 ) 859 - 66 2010.6

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DOI： 10.1016/j.humpath.2009.09.018
Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development. International journal

Nobuhiro Fujita, Shinichi Aishima, Tomohiro Iguchi, Yunosuke Nishihara, Hidetaka Yamamoto, Akinobu Taketomi, Yoshinao Oda, Hiroshi Honda, Masazumi Tsuneyoshi

Human pathology 41 ( 6 ) 838 - 47 2010.6

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DOI： 10.1016/j.humpath.2009.11.011
Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from the intestinal type. International journal

Yoshihiko Sadakari, Kenoki Ohuchida, Kohei Nakata, Takao Ohtsuka, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

Surgery 147 ( 6 ) 812 - 7 2010.6

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DOI： 10.1016/j.surg.2009.11.011
S100P is a novel marker to identify intraductal papillary mucinous neoplasms. International journal

Kohei Nakata, Eishi Nagai, Kenoki Ohuchida, Akifumi Hayashi, Yoshihiro Miyasaka, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi

Human pathology 41 ( 6 ) 824 - 31 2010.6

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DOI： 10.1016/j.humpath.2009.11.007
Sclerosed hemangioma of the liver: possible diagnostic value of diffusion-weighted magnetic resonance imaging.

Tomoyuki Hida, Akihiro Nishie, Tsuyoshi Tajima, Akinobu Taketomi, Shin-ichi Aishima, Hiroshi Honda

Japanese journal of radiology 28 ( 3 ) 235 - 8 2010.4

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DOI： 10.1007/s11604-009-0407-3
Unusual multiple gastric carcinoids with hypergastrinemia: report of a case.

Kohei Nakata, Shinichi Aishima, Hitoshi Ichimiya, Takashi Yao, Takashi Matsuura, Mitsuru Seo, Eishi Nagai, Masayuki Okido, Masato Kato, Mitsuru Nakagaki, Masazumi Tsuneyoshi, Masao Tanaka

Surgery today 40 ( 3 ) 267 - 71 2010.3

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DOI： 10.1007/s00595-009-4032-7
Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement. International journal

Yasuni Nakanuma, Yoh Zen, Kenichi Harada, Motoko Sasaki, Akitaka Nonomura, Takeshi Uehara, Kenji Sano, Fukuo Kondo, Toshio Fukusato, Koichi Tsuneyama, Masahiro Ito, Kenichi Wakasa, Minoru Nomoto, Hiroshi Minato, Hironori Haga, Masayoshi Kage, Hirohisa Yano, Joji Haratake, Shinichi Aishima, Tomoyuki Masuda, Hajime Aoyama, Aya Miyakawa-Hayashino, Toshiharu Matsumoto, Hayato Sanefuji, Hidenori Ojima, Tse-Ching Chen, Eunsil Yu, Ji-Hun Kim, Young Nyun Park, Wilson Tsui

Pathology international 60 ( 3 ) 167 - 74 2010.3

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DOI： 10.1111/j.1440-1827.2009.02500.x
Fascin expression in progression and prognosis of hepatocellular carcinoma. International journal

Tomohiro Iguchi, Shinichi Aishima, Kenji Umeda, Kensaku Sanefuji, Nobuhiro Fujita, Keishi Sugimachi, Tomonobu Gion, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Journal of surgical oncology 100 ( 7 ) 575 - 9 2009.12

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DOI： 10.1002/jso.21377
CD10+ fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma. International journal

Yunosuke Nishihara, Shinichi Aishima, Akifumi Hayashi, Tomohiro Iguchi, Nobuhiro Fujita, Akinobu Taketomi, Hiroshi Honda, Masazumi Tsuneyoshi

Histopathology 55 ( 4 ) 423 - 31 2009.10

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DOI： 10.1111/j.1365-2559.2009.03398.x
Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic study. International journal

Hidetaka Yamamoto, Hiroshi Yamaguchi, Shinichi Aishima, Yoshinao Oda, Kenichi Kohashi, Yumi Oshiro, Masazumi Tsuneyoshi

The American journal of surgical pathology 33 ( 9 ) 1330 - 40 2009.9

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DOI： 10.1097/PAS.0b013e3181a5a207
Both fibrous capsule formation and extracapsular penetration are powerful predictors of poor survival in human hepatocellular carcinoma: a histological assessment of 365 patients in Japan. International journal

Tomohiro Iguchi, Shinichi Aishima, Kensaku Sanefuji, Nobuhiro Fujita, Keishi Sugimachi, Tomonobu Gion, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Masazumi Tsuneyoshi

Annals of surgical oncology 16 ( 9 ) 2539 - 46 2009.9

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DOI： 10.1245/s10434-009-0453-1
LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer. International journal

Kohei Nakata, Kenoki Ohuchida, Eishi Nagai, Akifumi Hayashi, Yoshihiro Miyasaka, Tadashi Kayashima, Jun Yu, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi

Neoplasia (New York, N.Y.) 11 ( 7 ) 712 - 9 2009.7

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DOI： 10.1593/neo.09418
Erratum: Extracapsular penetration is a new prognostic factor in human hepatocellular carcinoma (American Journal of Surgical Pathology (2008) 32 (1675-1682))

T. Iguchi, S. Aishima, A. Taketomi

American Journal of Surgical Pathology 33 ( 3 ) 485 2009.3

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DOI： 10.1097/PAS.0b013e31819f584d
Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma. International journal

Shinichi Aishima, Tomohiro Iguchi, Yunosuke Nishihara, Nobuhiro Fujita, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Histopathology 54 ( 4 ) 452 - 61 2009.3

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DOI： 10.1111/j.1365-2559.2009.03240.x
Fascin overexpression is involved in carcinogenesis and prognosis of human intrahepatic cholangiocarcinoma: immunohistochemical and molecular analysis. International journal

Tomohiro Iguchi, Shinichi Aishima, Akinobu Taketomi, Yunosuke Nishihara, Nobuhiro Fujita, Kensaku Sanefuji, Keishi Sugimachi, Yo-ichi Yamashita, Yoshihiko Maehara, Masazumi Tsuneyoshi

Human pathology 40 ( 2 ) 174 - 80 2009.2

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DOI： 10.1016/j.humpath.2008.06.029
ヒト悪性腫瘍の病理組織形態と分子生物学的特性

恒吉正澄, 八尾隆史, 小田義直, 田宮貞史, 相島慎一, 山元英崇, 大石善丈, 平橋美奈子, 栗原秀一, 孝橋賢一

福岡醫學雜誌 100 ( 1 ) 13 - 25 2009.1

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Language：Japanese

DOI： 10.15017/13540
Biliary phenotype of hepatocellular carcinoma after preoperative transcatheter arterial chemoembolization. International journal

Yunosuke Nishihara, Shinichi Aishima, Yousuke Kuroda, Tomohiro Iguchi, Kenichi Taguchi, Yoshiki Asayama, Akinobu Taketomi, Naoko Kinukawa, Hiroshi Honda, Masazumi Tsuneyoshi

Journal of gastroenterology and hepatology 23 ( 12 ) 1860 - 8 2008.12

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DOI： 10.1111/j.1440-1746.2008.05601.x
Extracapsular penetration is a new prognostic factor in human hepatocellular carcinoma. International journal

Tomohiro Iguchi, Shinichi Aishima, Akinobu Taketomi, Yunosuke Nishihara, Nobuhiro Fujita, Kensaku Sanefuji, Yoshihiko Maehara, Masazumi Tsuneyoshi

The American journal of surgical pathology 32 ( 11 ) 1675 - 82 2008.11

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DOI： 10.1097/PAS.0b013e31817a8ed5
CD10 immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium. International journal

Yoshihiro Ohishi, Tsunehisa Kaku, Hiroaki Kobayashi, Shinichi Aishima, Yoshihisa Umekita, Norio Wake, Masazumi Tsuneyoshi

Human pathology 39 ( 10 ) 1446 - 53 2008.10

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DOI： 10.1016/j.humpath.2008.02.006
Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia. International journal

Shinichi Aishima, Yunosuke Nishihara, Eiji Tsujita, Kenichi Taguchi, Yuji Soejima, Akinobu Taketomi, Yasuharu Ikeda, Yoshihiko Maehara, Masazumi Tsuneyoshi

Human pathology 39 ( 6 ) 939 - 47 2008.6

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DOI： 10.1016/j.humpath.2007.10.031
Adenomatoid tumour of the liver

S. Nagata, S. Aishima, K. Fukuzawa, H. Takagi, H. Yonemasu, Y. Iwashita, T. Kinoshita, K. Wakasugi

Journal of Clinical Pathology 61 ( 6 ) 777 - 780 2008.6

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DOI： 10.1136/jcp.2007.054684
Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma. International journal

Shinichi Aishima, Yunosuke Nishihara, Tomohiro Iguchi, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 21 ( 3 ) 256 - 64 2008.3

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DOI： 10.1038/modpathol.3800985
Arterial blood supply of hepatocellular carcinoma and histologic grading: radiologic-pathologic correlation. International journal

Yoshiki Asayama, Kengo Yoshimitsu, Yunosuke Nishihara, Hiroyuki Irie, Shinichi Aishima, Akinobu Taketomi, Hiroshi Honda

AJR. American journal of roentgenology 190 ( 1 ) W28-34 2008.1

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DOI： 10.2214/AJR.07.2117
Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine. International journal

Nobito Higuchi, Masaki Kato, Kazuhiro Kotoh, Motoyuki Kohjima, Shinichi Aishima, Makoto Nakamuta, Yoshinori Fukui, Ryoichi Takayanagi, Munechika Enjoji

Liver international : official journal of the International Association for the Study of the Liver 27 ( 10 ) 1342 - 8 2007.12

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DOI： 10.1111/j.1478-3231.2007.01590.x
Down-regulation of aquaporin-1 in intrahepatic cholangiocarcinoma is related to tumor progression and mucin expression. International journal

Shinichi Aishima, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Tomohiro Iguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Human pathology 38 ( 12 ) 1819 - 25 2007.12

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DOI： 10.1016/j.humpath.2007.04.016
Expression profile of class I histone deacetylases in human cancer tissues. International journal

Masamune Nakagawa, Yoshinao Oda, Takashi Eguchi, Shin-Ichi Aishima, Takashi Yao, Fumihito Hosoi, Yuji Basaki, Mayumi Ono, Michihiko Kuwano, Masao Tanaka, Masazumi Tsuneyoshi

Oncology reports 18 ( 4 ) 769 - 74 2007.10

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DOI： 10.3892/or.18.4.769
Mucin-hypersecreting bile duct neoplasm characterized by clinicopathological resemblance to intraductal papillary mucinous neoplasm (IPMN) of the pancreas. International journal

Yo-Ichi Yamashita, Kengo Fukuzawa, Akinobu Taketomi, Shinichi Aishima, Tomoharu Yoshizumi, Hideaki Uchiyama, Eiji Tsujita, Norifumi Harimoto, Noboru Harada, Kenzo Wakasugi, Yoshihiko Maehara

World journal of surgical oncology 5 98 - 98 2007.8

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DOI： 10.1186/1477-7819-5-98
Role of growth factor receptor bound protein 7 in hepatocellular carcinoma. International journal

Shinji Itoh, Akinobu Taketomi, Shinji Tanaka, Norifumi Harimoto, Yo-ichi Yamashita, Shin-ichi Aishima, Takashi Maeda, Ken Shirabe, Mitsuo Shimada, Yoshihiko Maehara

Molecular cancer research : MCR 5 ( 7 ) 667 - 73 2007.7

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DOI： 10.1158/1541-7786.MCR-06-0282
14-3-3sigma negatively regulates the cell cycle, and its down-regulation is associated with poor outcome in intrahepatic cholangiocarcinoma. International journal

Yousuke Kuroda, Shinichi Aishima, Akinobu Taketomi, Yunosuke Nishihara, Tomohiro Iguchi, Kenichi Taguchi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Human pathology 38 ( 7 ) 1014 - 1022 2007.7

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DOI： 10.1016/j.humpath.2006.12.014
Proposal of progression model for intrahepatic cholangiocarcinoma: clinicopathologic differences between hilar type and peripheral type. International journal

Shinichi Aishima, Yousuke Kuroda, Yunosuke Nishihara, Tomohiro Iguchi, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

The American journal of surgical pathology 31 ( 7 ) 1059 - 67 2007.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/PAS.0b013e31802b34b6
Hepatoid adenocarcinoma of the stomach: histogenesis and progression in association with intestinal phenotype. International journal

Yumiko Kumashiro, Takashi Yao, Shinichi Aishima, Minako Hirahashi, Kenichi Nishiyama, Tomomi Yamada, Ryoichi Takayanagi, Masazumi Tsuneyoshi

Human pathology 38 ( 6 ) 857 - 63 2007.6

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DOI： 10.1016/j.humpath.2006.10.020
Histologic characteristics and prognostic significance in small hepatocellular carcinoma with biliary differentiation: subdivision and comparison with ordinary hepatocellular carcinoma. International journal

Shinichi Aishima, Yunosuke Nishihara, Yousuke Kuroda, Kenichi Taguchi, Tomohiro Iguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

The American journal of surgical pathology 31 ( 5 ) 783 - 91 2007.5

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DOI： 10.1097/01.pas.0000213421.53750.0a
Extended indication for living donor liver transplantation in patients with hepatocellular carcinoma

Yuji Soejima, Akinobu Taketomi, Tomoharu Yoshizumi, Hideaki Uchiyama, Shinich Aishima, Takahiro Terashi, Mitsuo Shimada, Yoshihiko Maehara

Transplantation 83 ( 7 ) 893 - 899 2007.4

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DOI： 10.1097/01.tp.0000259015.46798.ec
The predictors of microvascular invasion in candidates for liver transplantation with hepatocellular carcinoma-with special reference to the serum levels of des-gamma-carboxy prothrombin. International journal

Ken Shirabe, Shinji Itoh, Tomoharu Yoshizumi, Yuji Soejima, Akinobu Taketomi, Shin-Ichi Aishima, Yoshihiko Maehara

Journal of surgical oncology 95 ( 3 ) 235 - 40 2007.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/jso.20655
A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease. International journal

Tohru Utsunomiya, Masahiro Okamoto, Shigeki Wakiyama, Masaji Hashimoto, Kengo Fukuzawa, Takahiro Ezaki, Shinichi Aishima, Yasuji Yoshikawa, Taizo Hanai, Hiroshi Inoue, Graham-F Barnard, Masaki Mori

World journal of gastroenterology 13 ( 3 ) 383 - 90 2007.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3748/wjg.v13.i3.383
Proposal of a new staging and grading system of the liver for primary biliary cirrhosis

K. Hiramatsu, H. Aoyama, Y. Zen, S. Aishima, S. Kitagawa, Y. Nakanuma

Histopathology 49 ( 5 ) 466 - 478 2006.11

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DOI： 10.1111/j.1365-2559.2006.02537.x
Characteristic differences according to the cirrhotic pattern of advanced primary biliary cirrhosis: Macronodular cirrhosis indicates slow progression. International journal

Shinichi Aishima, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Hepatology research : the official journal of the Japan Society of Hepatology 36 ( 3 ) 188 - 94 2006.11

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DOI： 10.1016/j.hepres.2006.07.008
High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma. International journal

Shinichi Aishima, Yuji Basaki, Yoshinao Oda, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Fumihito Hosoi, Yuichiro Maruyama, Abbas Fotovati, Shinji Oie, Mayumi Ono, Takato Ueno, Michio Sata, Hirohisa Yano, Masamichi Kojiro, Michihiko Kuwano, Masazumi Tsuneyoshi

Cancer science 97 ( 11 ) 1182 - 90 2006.11

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DOI： 10.1111/j.1349-7006.2006.00322.x
Hepatocellular carcinoma with a prominent vascular scar in the center: MR imaging findings.

Madoka Yamauchi, Yoshiki Asayama, Kengo Yoshimitsu, Hiroyuki Irie, Tsuyoshi Tajima, Masakazu Hirakawa, Kousei Ishigami, Tomohiro Nakayama, Daisuke Kakihara, Koji Yamaguchi, Yunosuke Nishihara, Shinichi Aishima, Hiroshi Honda

Radiation medicine 24 ( 6 ) 467 - 70 2006.7

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DOI： 10.1007/s11604-006-0052-z
Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: Gastric foveolar type is associated with aggressive tumour behaviour

S. Aishima, Y. Kuroda, Y. Nishihara, K. Taguchi, A. Taketomi, Y. Maehara, M. Tsuneyoshi

Histopathology 49 ( 1 ) 35 - 44 2006.7

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DOI： 10.1111/j.1365-2559.2006.02414.x
Prognostic impact of cholangiocellular and sarcomatous components in combined hepatocellular and cholangiocarcinoma. International journal

Shinichi Aishima, Yousuke Kuroda, Yoshiki Asayama, Kenichi Taguchi, Yunosuke Nishihara, Akinobu Taketomi, Masazumi Tsuneyoshi

Human pathology 37 ( 3 ) 283 - 91 2006.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.humpath.2005.08.019
[Mechanism of biliary carcinogenesis: Hepatotropic hepatis virus].

Kenichi Taguchi, Shinichi Aishima, Masazumi Tsuneyoshi

Nihon rinsho. Japanese journal of clinical medicine 64 Suppl 1 362 - 5 2006.1

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Language：Japanese Publishing type：Research paper (scientific journal)
Delayed-phase dynamic CT enhancement as a prognostic factor for mass-forming intrahepatic cholangiocarcinoma. International journal

Yoshiki Asayama, Kengo Yoshimitsu, Hiroyuki Irie, Tsuyoshi Tajima, Akihiro Nishie, Masakazu Hirakawa, Tomohiro Nakayama, Daisuke Kakihara, Akinobu Taketomi, Shin-ichi Aishima, Hiroshi Honda

Radiology 238 ( 1 ) 150 - 5 2006.1

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DOI： 10.1148/radiol.2381041765
Significance of the relationship between irregular regeneration and two hepatocarcinogenic pathways: "de novo" and so-called "dysplastic nodule-hepatocellular carcinoma" sequence. International journal

Kenichi Taguchi, Shinichi Aishima, Shuji Matsuura, Takahiro Terashi, Kenichi Nishiyama, Ken Shirabe, Mitsuo Shimada, Yoshihiko Maehara, Masazumi Tsuneyoshi

Journal of surgical oncology 92 ( 2 ) 100 - 3 2005.11

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DOI： 10.1002/jso.20293
サイトメガロウイルス感染症と出血性直腸潰瘍を合併した成人スチル病の1例

檜沢一興, 相島慎一, 八尾隆史, 中原束, 松本主之, 飯田三雄

日本消化器病学会雑誌 102 ( 10 ) 1281 - 5 2005.10

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症例は84歳女性．成人スチル病の診断でステロイド治療中に大量下血を生じ，2003年6月4日，当科緊急入院となった．直腸に巨大潰瘍あり，生検組織像にて虚血性変化と薬剤性粘膜障害の所見を認めた．さらにCMVantigenemia陽性のためgancyclovir併用し，中心静脈栄養療法を継続した．経過中antigenemia再上昇にともない下血が再燃した．gancyclovir継続後は下血なく，2004年3月16日，成人スチル病のため死亡した．

DOI： 10.11405/nisshoshi.102.1281
'Scirrhous' type hepatocellular carcinomas: A special reference to expression of cytokeratin 7 and hepatocyte paraffin 1

S. Matsuura, S. Aishima, K. Taguchi, Y. Asayama, T. Terashi, H. Honda, Masazumi Tsuneyoshi

Histopathology 47 ( 4 ) 382 - 390 2005.10

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DOI： 10.1111/j.1365-2559.2005.02230.x
Short-term intensive treatment for donors with hepatic steatosis in living-donor liver transplantation

Makoto Nakamuta, Shusuke Morizono, Yuji Soejima, Tomoharau Yoshizumi, Shinji Aishima, Shin Ichiro Takasugi, Kengo Yoshimitsu, Munechika Enjoji, Kazuhiro Kotoh, Akinobu Taketomi, Hideaki Uchiyama, Mitsuo Shimada, Hajime Nawata, Yoshihiko Maehara

Transplantation 80 ( 5 ) 608 - 612 2005.9

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DOI： 10.1097/01.tp.0000166009.77444.f3
Bronchiolitis obliterans organizing pneumonia as an initial manifestation in systemic lupus erythematosus. International journal

Hidetoshi Takada, Yusuke Saito, Akihiko Nomura, Shouichi Ohga, Kazuyoshi Kuwano, Nobutaka Nakashima, Shinichi Aishima, Noboru Tsuru, Toshiro Hara

Pediatric pulmonology 40 ( 3 ) 257 - 60 2005.9

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DOI： 10.1002/ppul.20224
Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement. International journal

Yoh Zen, Shinichi Aishima, Yoichi Ajioka, Joji Haratake, Masayoshi Kage, Fukuo Kondo, Yuji Nimura, Michiie Sakamoto, Motoko Sasaki, Kazuhide Shimamatsu, Kenichi Wakasa, Young Nyun Park, Ming F Chen, Yutaka Atomi, Yasuni Nakanuma

Pathology international 55 ( 4 ) 180 - 8 2005.4

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DOI： 10.1111/j.1440-1827.2005.01816.x
Detection of combined hepatocellular and cholangiocarcinomas on enhanced CT: comparison with histologic findings. International journal

Akihiro Nishie, Kengo Yoshimitsu, Yoshiki Asayama, Hiroyuki Irie, Hitoshi Aibe, Tsuyoshi Tajima, Kenji Shinozaki, Tomohiro Nakayama, Daisuke Kakihara, Mitsuo Shimada, Shin-Ichi Aishima, Kisaku Yoshida, Hiroshi Honda

AJR. American journal of roentgenology 184 ( 4 ) 1157 - 62 2005.4

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DOI： 10.2214/ajr.184.4.01841157
バルプロ酸ナトリウムにより高アンモニア血症をきたしたC型慢性肝炎の1例

福嶋真理恵, 古藤和浩, 遠城寺宗近, 中牟田誠, 名和田新, 相島慎一

日本消化器病学会雑誌 102 ( 1 ) 42 - 7 2005.1

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症例は45歳，男性．平成10年より慢性硬膜血腫術後のてんかん発作にて，近医経過観察中，高アンモニア血症を指摘され，平成13年5月当科に紹介入院．HCV-RNA陽性だが肝予備能低下なく，門脈大循環へのシャントなく，アミノ酸分析正常であった．薬剤の関与としてバルプロ酸ナトリウムが考えられ，減量中止したところアンモニア値は改善した．基礎病変として肝疾患を持つ症例においても，常に薬剤による高アンモニア血症に考慮して診療にあたるべきと考えられた．

DOI： 10.11405/nisshoshi.102.42, 10.2957/kanzo.59.421_references_DOI_7iqc9gI6LrFzakFaQecy4g2pG30
The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C. International journal

Norifumi Harimoto, Mitsuo Shimada, Shin-ichi Aishima, Dai Kitagawa, Shinji Itoh, Eiji Tsujita, Shin-ichiro Maehara, Akinobu Taketomi, Shinji Tanaka, Ken Shirabe, Yoshihiko Maehara

Liver international : official journal of the International Association for the Study of the Liver 24 ( 4 ) 316 - 21 2004.8

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DOI： 10.1111/j.1478-3231.2004.0927.x
The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C. International journal

Norifumi Harimoto, Mitsuo Shimada, Shin-ichi Aishima, Dai Kitagawa, Shinji Itoh, Eiji Tsujita, Shin-ichiro Maehara, Akinobu Taketomi, Shinji Tanaka, Ken Shirabe, Yoshihiko Maehara

Liver international : official journal of the International Association for the Study of the Liver 24 ( 4 ) 316 - 21 2004.8

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DOI： 10.1111/j.1478-3231.2004.0927.x
Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. International journal

Shinji Itoh, Takashi Maeda, Mitsuo Shimada, Shin-ichi Aishima, Ken Shirabe, Shinji Tanaka, Yoshihiko Maehara

Clinical cancer research : an official journal of the American Association for Cancer Research 10 ( 8 ) 2812 - 7 2004.4

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DOI： 10.1158/1078-0432.CCR-1046-03
Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis. International journal

Ken Shirabe, Mitsuo Shimada, Eiji Tsujita, Shin-ichi Aishima, Shin-ichiroh Maehara, Sinji Tanaka, Kenji Takenaka, Yoshihiko Maehara

American journal of surgery 187 ( 4 ) 538 - 42 2004.4

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DOI： 10.1016/j.amjsurg.2003.12.044
Decreased expression of osteopontin is related to tumor aggressiveness and clinical outcome of intrahepatic cholangiocarcinoma. International journal

Takahiro Terashi, Shinichi Aishima, Kenichi Taguchi, Yoshiki Asayama, Keishi Sugimachi, Shuji Matsuura, Mitsuo Shimada, Shinichiro Maehara, Yoshihiko Maehara, Masazumi Tsuneyoshi

Liver international : official journal of the International Association for the Study of the Liver 24 ( 1 ) 38 - 45 2004.2

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DOI： 10.1111/j.1478-3231.2004.00886.x
Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma

K. Sugimachi, S. Tanaka, K. Taguchi, S. Aishima, M. Shimada, K. Sugimachi, M. Tsuneyoshi

Journal of Clinical Pathology 56 ( 11 ) 854 - 860 2003.11

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DOI： 10.1136/jcp.56.11.854
Tenascin expression at the invasive front is associated with poor prognosis in intrahepatic cholangiocarcinoma. International journal

Shin-Ichi Aishima, Ken-Ichi Taguchi, Takahiro Terashi, Shuji Matsuura, Mitsuo Shimada, Masazumi Tsuneyoshi

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 16 ( 10 ) 1019 - 27 2003.10

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DOI： 10.1097/01.MP.0000086860.65672.73
Tenascin expression at the invasive front is associated with poor prognosis in intrahepatic cholangiocarcinoma. International journal

Shin-Ichi Aishima, Ken-Ichi Taguchi, Takahiro Terashi, Shuji Matsuura, Mitsuo Shimada, Masazumi Tsuneyoshi

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 16 ( 10 ) 1019 - 27 2003.10

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/01.MP.0000086860.65672.73
Transcriptional repressor snail and progression of human hepatocellular carcinoma. International journal

Keishi Sugimachi, Shinji Tanaka, Toshifumi Kameyama, Ken-ichi Taguchi, Shin-ichi Aishima, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

Clinical cancer research : an official journal of the American Association for Cancer Research 9 ( 7 ) 2657 - 64 2003.7

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Transcriptional repressor snail and progression of human hepatocellular carcinoma. International journal

Keishi Sugimachi, Shinji Tanaka, Toshifumi Kameyama, Ken-ichi Taguchi, Shin-ichi Aishima, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

Clinical cancer research : an official journal of the American Association for Cancer Research 9 ( 7 ) 2657 - 64 2003.7

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Sarcomatous hepatocellular carcinoma: a special reference to ordinary hepatocellular carcinoma. International journal

Hidehiro Nishi, Ken-ichi Taguchi, Yoshiki Asayama, Shin-ichi Aishima, Keishi Sugimachi, Hajime Nawata, Masazumi Tsuneyoshi

Journal of gastroenterology and hepatology 18 ( 4 ) 415 - 23 2003.4

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1046/j.1440-1746.2003.02888.x
Sarcomatous hepatocellular carcinoma: a special reference to ordinary hepatocellular carcinoma. International journal

Hidehiro Nishi, Ken-ichi Taguchi, Yoshiki Asayama, Shin-ichi Aishima, Keishi Sugimachi, Hajime Nawata, Masazumi Tsuneyoshi

Journal of gastroenterology and hepatology 18 ( 4 ) 415 - 23 2003.4

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DOI： 10.1046/j.1440-1746.2003.02888.x
The utility of keratin 903 as a new prognostic marker in mass-forming-type intrahepatic cholangiocarcinoma. International journal

Shin-Ichi Aishima, Yoshiki Asayama, Ken-Ichi Taguchi, Keishi Sugimachi, Ken Shirabe, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 15 ( 11 ) 1181 - 90 2002.11

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/01.MP.0000032537.82380.69
The utility of keratin 903 as a new prognostic marker in mass-forming-type intrahepatic cholangiocarcinoma. International journal

Shin-Ichi Aishima, Yoshiki Asayama, Ken-Ichi Taguchi, Keishi Sugimachi, Ken Shirabe, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 15 ( 11 ) 1181 - 90 2002.11

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/01.MP.0000032537.82380.69
Coexpression of neural cell adhesion molecules and bcl-2 in intrahepatic cholangiocarcinoma originated from viral hepatitis: relationship to atypical reactive bile ductule. International journal

Yoshiki Asayama, Shin-Ichi Aishima, Ken-Ichi Taguchi, Keishi Sugimachi, Shuji Matsuura, Kouji Masuda, Masazumi Tsuneyoshi

Pathology international 52 ( 4 ) 300 - 6 2002.4

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DOI： 10.1046/j.1440-1827.2002.01349.x
Coexpression of neural cell adhesion molecules and bcl-2 in intrahepatic cholangiocarcinoma originated from viral hepatitis: relationship to atypical reactive bile ductule. International journal

Yoshiki Asayama, Shin-Ichi Aishima, Ken-Ichi Taguchi, Keishi Sugimachi, Shuji Matsuura, Kouji Masuda, Masazumi Tsuneyoshi

Pathology international 52 ( 4 ) 300 - 6 2002.4

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DOI： 10.1046/j.1440-1827.2002.01349.x
The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. International journal

Shin-ichi Aishima, Ken-ichi Taguchi, Keishi Sugimachi, Yoshiki Asayama, Hidehiro Nishi, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

International journal of surgical pathology 10 ( 1 ) 47 - 56 2002.1

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DOI： 10.1177/106689690201000108
Clinicopathologic risk factors for recurrence after a curative hepatic resection for hepatocellular carcinoma. International journal

Eisuke Adachi, Shin-ichiro Maehara, Eiji Tsujita, Ken-ichi Taguchi, Shin-ichi Aishima, Tatsuya Rikimaru, Yo-ichi Yamashita, Shinji Tanaka

Surgery 131 ( 1 Suppl ) S148-52 2002.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1067/msy.2002.119496
Intrahepatic cholangiocarcinoma: its mode of spreading and therapeutic modalities. International journal

Ken Shirabe, Mitsuo Shimada, Norifumi Harimoto, Keishi Sugimachi, Yo-ichi Yamashita, Eiji Tsujita, Shin-ichi Aishima

Surgery 131 ( 1 Suppl ) S159-64 2002.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1067/msy.2002.119498
The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. International journal

Shin-ichi Aishima, Ken-ichi Taguchi, Keishi Sugimachi, Yoshiki Asayama, Hidehiro Nishi, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

International journal of surgical pathology 10 ( 1 ) 47 - 56 2002.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1177/106689690201000108
Clinicopathologic risk factors for recurrence after a curative hepatic resection for hepatocellular carcinoma. International journal

Eisuke Adachi, Shin-ichiro Maehara, Eiji Tsujita, Ken-ichi Taguchi, Shin-ichi Aishima, Tatsuya Rikimaru, Yo-ichi Yamashita, Shinji Tanaka

Surgery 131 ( 1 Suppl ) S148-52 2002.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1067/msy.2002.119496
Intrahepatic cholangiocarcinoma: its mode of spreading and therapeutic modalities. International journal

Ken Shirabe, Mitsuo Shimada, Norifumi Harimoto, Keishi Sugimachi, Yo-ichi Yamashita, Eiji Tsujita, Shin-ichi Aishima

Surgery 131 ( 1 Suppl ) S159-64 2002.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1067/msy.2002.119498
S05-04 肝内胆管癌に対する切除の問題点と戦略

調憲, 島田光生, 竹中賢治, 田中真二, 山下洋市, 相島慎一, 杉町圭蔵

日本消化器外科学会雑誌 34 ( 7 ) 824 2001.7

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The role of des-γ-carboxy prothrombin levels in hepatocellular carcinoma and liver tissues

159 ( 1 ) 87 - 94 2000.10

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We aimed to clarify the clinical significance of des-γ-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC, who underwent hepatectomy, were studied. Surgical specimens were obtained from both HCC and non-cancerous liver of each patient. After the preparation of the liver tissues, including tissues with HCC, the DCP levels both in HCC and non-cancerous liver tissue were measured using an electro-chemiluminescence immunoassay. The correlation was investigated between DCP levels and other clinicopathological factors. The DCP level of HCC ranged from 55 to 77 735 U/0.1 g tissue weight, with a median of 2801, while the DCP level of non-cancerous parts of the liver ranged from 24 to 721 U/0.1 g tissue weight, with a median of 86. The DCP level in the liver tissue in patients having a multicentric occurrence of HCC was significantly higher than that in patients without multicentric occurrence of HCC. The logarithm of the plasma DCP level correlated with that of the DCP level in HCC (correlation coefficient = 0.46; P < 0.05). No significant correlation was found between the DCP level in HCC and other clinicopathological parameters. The DCP level in non-cancerous parts of the liver with simultaneous multicentric occurrence of HCC was significantly higher than that in the liver without multicentric HCC. Furthermore, the DCP level in non-cancerous parts of the liver was one of the most important predictable factors of the multicentric occurrence of HCCs among various clinicopathological factors. Therefore, the DCP level may have an important role in hepatocarcinogenesis. (C) 2000 Elsevier Science Ireland Ltd.

DOI： 10.1016/S0304-3835(00)00539-5
The role of des-γ-carboxy prothrombin levels in hepatocellular carcinoma and liver tissues

159 ( 1 ) 87 - 94 2000.10

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Language：Others Publishing type：Research paper (scientific journal)

We aimed to clarify the clinical significance of des-γ-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC, who underwent hepatectomy, were studied. Surgical specimens were obtained from both HCC and non-cancerous liver of each patient. After the preparation of the liver tissues, including tissues with HCC, the DCP levels both in HCC and non-cancerous liver tissue were measured using an electro-chemiluminescence immunoassay. The correlation was investigated between DCP levels and other clinicopathological factors. The DCP level of HCC ranged from 55 to 77 735 U/0.1 g tissue weight, with a median of 2801, while the DCP level of non-cancerous parts of the liver ranged from 24 to 721 U/0.1 g tissue weight, with a median of 86. The DCP level in the liver tissue in patients having a multicentric occurrence of HCC was significantly higher than that in patients without multicentric occurrence of HCC. The logarithm of the plasma DCP level correlated with that of the DCP level in HCC (correlation coefficient = 0.46; P < 0.05). No significant correlation was found between the DCP level in HCC and other clinicopathological parameters. The DCP level in non-cancerous parts of the liver with simultaneous multicentric occurrence of HCC was significantly higher than that in the liver without multicentric HCC. Furthermore, the DCP level in non-cancerous parts of the liver was one of the most important predictable factors of the multicentric occurrence of HCCs among various clinicopathological factors. Therefore, the DCP level may have an important role in hepatocarcinogenesis. (C) 2000 Elsevier Science Ireland Ltd.

DOI： 10.1016/S0304-3835(00)00539-5
Clinicopathologic features and postoperative prognosis of multicentric small hepatocellular carcinoma

Tohru Utsunomiya, Mitsuo Shimada, Ken Ichi Taguchi, Hirofumi Hasegawa, Yoichi Yamashita, Takayuki Hamatsu, Shin Ichi Aishima, Keizo Sugimachi

Journal of the American College of Surgeons 190 ( 3 ) 331 - 335 2000.3

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DOI： 10.1016/S1072-7515(99)00268-9
Clinicopathologic features and postoperative prognosis of multicentric small hepatocellular carcinoma

Tohru Utsunomiya, Mitsuo Shimada, Ken Ichi Taguchi, Hirofumi Hasegawa, Yoichi Yamashita, Takayuki Hamatsu, Shin Ichi Aishima, Keizo Sugimachi

Journal of the American College of Surgeons 190 ( 3 ) 331 - 335 2000.3

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DOI： 10.1016/S1072-7515(99)00268-9

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Books

わかりやすい病理学

小田, 義直, 相島, 慎一, 恒吉, 正澄

南江堂 2021.3

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Responsible for pages：総ページ数：xix, 354p Language：Japanese
わかりやすい病理学

恒吉, 正澄, 小田, 義直, 相島, 慎一

南江堂 2021.3

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Responsible for pages：総ページ数：19,354p Language：Japanese

Presentations

系統的病理診断講習会２胆道系疾患の病理 Invited

相島慎一

第113回日本病理学会総会 2024.4

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Event date： 2024.4 - 2024.5

Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech

Venue：名古屋（WEB配信） Country：Japan

胆道系疾患の病理診断に関して解説する（オンデマンド配信 60分）
系統的病理診断講習会２胆道系疾患の病理 Invited

相島慎一

第113回日本病理学会総会 2024.4

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Event date： 2024.4 - 2024.5

Language：Japanese

Venue：名古屋（WEB配信） Country：Japan

胆道系疾患の病理診断に関して解説する（オンデマンド配信 60分）

researchmap
肝胆道癌の病理学的分類と遺伝子検査 Invited

相島慎一

第5回肝胆膵外科制癌治療研究会 2024.3

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Event date： 2024.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京都中央区日本橋 Country：Japan
肝胆道癌の病理学的分類と遺伝子検査 Invited

相島慎一

第5回肝胆膵外科制癌治療研究会 2024.3

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Event date： 2024.3

Language：Japanese

Venue：東京都中央区日本橋 Country：Japan

researchmap
肝胆膵領域の病理学の現状とこれから Invited

相島慎一

2024.1

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Event date： 2024.1

Language：Japanese Presentation type：Oral presentation (general)

Venue：ホテルニューオータニ博多 Country：Japan
肝胆膵領域の病理学の現状とこれから Invited

相島慎一

New Year Seminar 2024.1

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Event date： 2024.1

Language：Japanese

Venue：ホテルニューオータニ博多 Country：Japan

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肝胆道領域の病理診断 Invited

相島慎一

第62回日本臨床細胞学会秋期大会 2023.11

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Event date： 2023.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
肝胆道領域の病理診断 Invited

相島慎一

第62回日本臨床細胞学会秋期大会 2023.11

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Event date： 2023.11

Language：Japanese

Venue：福岡市 Country：Japan

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微小脈管侵襲の病理診断

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第59回肝癌研究会 2023.7

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Event date： 2023.7

Language：Japanese Presentation type：Symposium, workshop panel (public)

Venue：大阪府 Country：Japan
微小脈管侵襲の病理診断

相島慎一

第59回肝癌研究会 2023.7

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Event date： 2023.7

Language：Japanese

Venue：大阪府 Country：Japan

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心房細動患者における心房拡大と関連する病理組織学的因子　心房心筋生検200例の検討

高橋佑弥, 山口尊則, 大坪豊和, 中島夏奈, 新里広大, 大迫亮介, 野出孝一, 福井暁, 廣田慧, 高橋尚彦, 川口淳, 相島慎一

心臓 2022.11 (公財)日本心臓財団

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心房細動患者における心房bipolar voltageの組織学的決定因子(Histological determinants of Atrial Bipolar Voltage in Patients with Atrial Fibrillation)

高橋佑弥, 山口尊則, 大坪豊和, 中島夏奈, 新里広大, 大迫亮介, 七田茂樹, 河野佑貴, 福井暁, 川口淳, 相島慎一, 高橋尚彦, 野出孝一, 山本一博

日本心臓病学会学術集会抄録 2022.9 (一社)日本心臓病学会

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多発性骨髄腫を背景とした心停止後症候群の経過中にサイトメガロウイルス肺炎を合併し死亡に至った1剖検例

本村彩紀, 松岡綾華, 朝日美穂, 木庭真由子, 小網博之, 井樋有紗, 甲斐敬太, 相島慎一, 阪本雄一郎

日本救急医学会雑誌 2022.10 (一社)日本救急医学会

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副鼻腔原発神経内分泌癌の1例

宮本晃多, 江頭玲子, 福井修一, 入江裕之, 佐藤有記, 木戸伸一, 相島慎一

Japanese Journal of Radiology 2024.2 (公社)日本医学放射線学会

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上部消化管疾患の低侵襲治療　当院における下咽頭表在癌に対する消化器・耳鼻科合同治療の現状

芥川剛至, 石田知也, 下田良, 相島慎一, 江崎幹宏

日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集 2022.12 日本消化器病学会-九州支部

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Ultrafast Dynamic MRIによるMaximum Slopeを用いた子宮体癌の組織学的悪性度の予測(Prediction of Histological Grade of Endometrial Cancer with Measurements of Maximum Slope of Ultrafast Dynamic Contrast-Enhanced MRI)

Fukui Shuichi, Yamaguchi Ken, Egashira Ryoko, Nakazono Takahiko, Yokoyama Masatoshi, Aishima Shinichi, Irie Hiroyuki

日本医学放射線学会学術集会抄録集 2022.3 (公社)日本医学放射線学会

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胆道系疾患の病理

相島慎一

日本病理学会会誌 2024.2 (一社)日本病理学会

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消化器　肝の線維化診断update　肝病変に対する線維化の病理学的評価

相島慎一

Japanese Journal of Diagnostic Imaging 2023.2 日本画像医学会

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STAT6陽性、S-100陽性、Melan A陽性を示す間葉系髄内腫瘍の一例

中原由紀子, 伊藤寛, 並川裕貴, 増岡淳, 甲斐敬太, 相島慎一, 阿部竜也

Brain Tumor Pathology 2023.5 日本脳腫瘍病理学会

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Perry病同一家系3症例(DCTN1 F52L変異)の臨床病理学的検討

本田裕之, 笹ヶ迫直一, 原英夫, 三嶋崇靖, 濱崎英臣, 吉村基, 八木田薫, 栄信孝, 相島慎一, 坪井義夫, 岩城徹

臨床神経学 2022.10 (一社)日本神経学会

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IPNBの組織分類(Type 1,Type 2)に関する検討

島田有貴, 山本猛雄, 松本昴, 野口彰子, 山田裕, 仲田興平, 相島慎一, 小田義直, 中村雅史

日本消化器外科学会総会 2024.7 (一社)日本消化器外科学会

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Gerstmann-Straussler-Scheinker diseaseにおけるresident microgliaの挙動

本田裕之, 野口英子, 野上健一郎, 渡邉暁博, 栄信孝, 荒畑創, 河野祐治, 山本明史, 甲斐敬太, 相島慎一, 笹ヶ迫直一

国立病院総合医学会講演抄録集 2023.10 国立病院総合医学会

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EUS-FNAの細胞診断,膵領域と周辺臓器の小型円形細胞性腫瘍の鑑別

大久保文彦, 山口知彦, 野上美和子, 中附加奈子, 木村理恵, 仲正喜, 山本猛雄, 岩崎健, 相島慎一, 小田義直

日本臨床細胞学会雑誌 2024.5 (公社)日本臨床細胞学会

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EUS-FNAの細胞診断,異型の弱い通常型膵癌,十二指腸癌とピットフォール

大久保文彦, 山口知彦, 野上美和子, 仲正喜, 中附加奈子, 木村理恵, 山本猛雄, 岩崎健, 相島慎一, 小田義直

日本臨床細胞学会雑誌 2024.5 (公社)日本臨床細胞学会

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CTを契機に発見された消化管AL型アミロイドーシスの一例

西田大輝, 芥川剛至, 藤田真衣, 沖井詩織, 水田優実, 島村拓弥, 行元崇浩, 相島慎一, 江崎幹宏

日本消化管学会雑誌 2024.1 (一社)日本消化管学会

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Ultrafast Dynamic MRIによるMaximum Slopeを用いた子宮体癌の組織学的悪性度の予測(Prediction of Histological Grade of Endometrial Cancer with Measurements of Maximum Slope of Ultrafast Dynamic Contrast-Enhanced MRI)

Fukui Shuichi, Yamaguchi Ken, Egashira Ryoko, Nakazono Takahiko, Yokoyama Masatoshi, Aishima Shinichi, Irie Hiroyuki

日本医学放射線学会学術集会抄録集 2022.3 (公社)日本医学放射線学会

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カボザンチニブ投与後に肝細胞癌腫瘍内出血を来した1例

森美哉子, 桑代卓也, 湯ノ谷修三, 川添夕佳, 田中賢一, 井上香, 磯田広史, 大枝敏, 秋山巧, 江頭秀哲, 相島慎一, 高橋宏和

日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集 2023.5 日本消化器病学会-九州支部

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リンパ管拡張様所見を呈した食道胃接合部癌の十二指腸転移の一例

中村啓太, 芥川剛至, 行元崇浩, 松尾真紀子, 井上須磨, 島村拓弥, 佐野晴彦, 勝屋弘雄, 前田佐知子, 相島慎一, 木村晋也, 江崎幹宏

日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集 2022.12 日本消化器病学会-九州支部

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上部消化管疾患の低侵襲治療　当院における下咽頭表在癌に対する消化器・耳鼻科合同治療の現状

芥川剛至, 石田知也, 下田良, 相島慎一, 江崎幹宏

日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集 2022.12 日本消化器病学会-九州支部

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副鼻腔原発神経内分泌癌の1例

宮本晃多, 江頭玲子, 福井修一, 入江裕之, 佐藤有記, 木戸伸一, 相島慎一

Japanese Journal of Radiology 2024.2 (公社)日本医学放射線学会

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外科切除検体を用いた画像解析ソフトによる肝細胞癌と肝内胆管癌の細胞学的比較検討

北村捷, 甲斐敬太, 中村光男, 田中智和, 井手貴雄, 能城浩和, 末岡榮三朗, 相島慎一

日本臨床細胞学会雑誌 2023.10 (公社)日本臨床細胞学会

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多発性骨髄腫を背景とした心停止後症候群の経過中にサイトメガロウイルス肺炎を合併し死亡に至った1剖検例

本村彩紀, 松岡綾華, 朝日美穂, 木庭真由子, 小網博之, 井樋有紗, 甲斐敬太, 相島慎一, 阪本雄一郎

日本救急医学会雑誌 2022.10 (一社)日本救急医学会

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心房細動患者における心房bipolar voltageの組織学的決定因子(Histological determinants of Atrial Bipolar Voltage in Patients with Atrial Fibrillation)

高橋佑弥, 山口尊則, 大坪豊和, 中島夏奈, 新里広大, 大迫亮介, 七田茂樹, 河野佑貴, 福井暁, 川口淳, 相島慎一, 高橋尚彦, 野出孝一, 山本一博

日本心臓病学会学術集会抄録 2022.9 (一社)日本心臓病学会

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心房細動患者における心房拡大と関連する病理組織学的因子　心房心筋生検200例の検討

高橋佑弥, 山口尊則, 大坪豊和, 中島夏奈, 新里広大, 大迫亮介, 野出孝一, 福井暁, 廣田慧, 高橋尚彦, 川口淳, 相島慎一

心臓 2022.11 (公財)日本心臓財団

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新時代の肝疾患診療　Biopsy-proven SLDにおけるMetALDの実態と肝病理所見　多施設共同レジストリーCLIONE study

高橋宏和, 川口巧, 堤翼, 藤井英樹, 鎌田佳宏, 川中美和, 角田圭雄, 岩城慶大, 林秀樹, 豊田秀徳, 大枝敏, 米田正人, 相島慎一, 中島淳

日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集 2024.6 日本消化器病学会-九州支部

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消化器　肝の線維化診断update　肝病変に対する線維化の病理学的評価

相島慎一

Japanese Journal of Diagnostic Imaging 2023.2 日本画像医学会

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涙腺多形腺腫の1例

本吉郁哉, 北村捷, 甲斐敬太, 並川裕貴, 前田佐知子, 橋口真理子, 上瀧さやか, 吉岡史隆, 相島慎一, 末岡榮三朗

日本臨床細胞学会雑誌 2023.5 (公社)日本臨床細胞学会

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肝胆道領域の病理診断

相島慎一

日本臨床細胞学会雑誌 2023.10 (公社)日本臨床細胞学会

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胆道系疾患の病理

相島慎一

日本病理学会会誌 2024.2 (一社)日本病理学会

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鼻尖部偽リンパ腫として治療中に、口唇や眼瞼に結節を生じた粘膜関連リンパ組織節外性辺縁帯リンパ腫

岡莉恵, 井上卓也, 西純平, 相島慎一, 大島孝一, 永瀬浩太郎, 杉田和成

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 2022.5 (一社)日本皮膚悪性腫瘍学会

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超短期間のレンバチニブ投与で抗腫瘍効果に差異を認めた肝細胞癌の一例

木塚雅之, 福本一樹, 木村俊一郎, 田中賢一, 桑代卓也, 秋山巧, 相島慎一, 安西慶三, 高橋宏和

肝臓 2022.4 (一社)日本肝臓学会

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【膵・胆道癌の発生・進展メカニズムを探る】胆道癌の発生・進展に関する病理形態学的変化

相島慎一

胆と膵 45 ( 8 ) 823 - 828 2024.8 （ ISSN:0388-9408 ）

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胆道癌は胆汁排泄経路に発生する癌腫であり,肝内および肝外胆管,胆嚢・胆嚢管,乳頭部までが含まれ,その発生部位により形成される癌腫は,肝内胆管癌,肝門部領域胆管癌,遠位胆管癌,胆嚢癌,乳頭部癌などに分類される。ほとんどは組織学的に腺癌で構成され,肉眼的に類似する形態像を示すことがあるものの,発癌経路や遺伝子異常や予後が異なる。また病理診断や発生・進展機序に関して解決すべき課題を多く含む領域でもある。本稿では,胆道癌の発生・進展に焦点をあてて肉眼的な特徴,組織像,発癌の危険因子および病理診断についての問題点を概説する。(著者抄録)
後腹膜に嚢胞状転移巣を形成した,非常に稀な顎下腺腺様嚢胞癌の1例

三根夢花, 甲斐敬太, 北村捷, 川崎佳奈子, 山内盛泰, 馬塲耕一, 倉富勇一郎, 能城浩和, 末岡榮三朗, 相島慎一

日本臨床細胞学会九州連合会雑誌 55 47 - 51 2024.7 （ ISSN:0912-6600 ）

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背景腺様嚢胞癌の遠隔転移は肺や骨が多く,後腹膜転移は稀である.今回,後腹膜に嚢胞状腫瘤を形成し,臨床的に乳癌の転移が疑われたが,嚢胞内容液の細胞診で顎下腺原発腺様嚢胞癌の後腹膜転移と推定しえた1例を経験したので報告する.症例 60歳代女性.右側腹部腫瘤を主訴に前医を受診し,精査により右骨盤部後腹膜に骨破壊を伴う嚢胞性腫瘍と左乳房腫瘤を指摘された.左乳房腫瘤は生検で乳癌(浸潤性乳管癌)の診断となり,加療目的に当院紹介となった.後腹膜腫瘍に対しては乳癌転移疑いとして穿刺吸引細胞診が施行されたが,腺様嚢胞癌を疑う異型細胞を認めるも確定診断には至らなかった.その後MRIで左顎下腺に長径約5cm大の腫瘤が認められ,穿刺吸引細胞診で腺様嚢胞癌の診断となった.後腹膜腫瘍が乳癌の転移か,腺様嚢胞癌の転移かの鑑別目的に,再度嚢胞内容液の穿刺吸引細胞診が施行され,腺様嚢胞癌の後腹膜転移の診断となった.結語腺様嚢胞癌はその特徴的な細胞形態に着目し,ギムザ染色やセルブロックによる免疫組織化学を加味することで細胞診検体による推定が可能である.自験例の様に,腺様嚢胞癌は転移好発臓器以外にも転移巣を形成することがあるので,細胞診判定の際には留意が必要である.(著者抄録)

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【微小環境から読み解く胆膵癌】胆道癌　肝内胆管癌のサブタイプと腫瘍微小環境

相島慎一

肝胆膵 88 ( 5 ) 605 - 611 2024.5 （ ISSN:0389-4991 ）

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Subtype and tumor microenvironment of intrahepatic cholangiocarcinoma

相島慎一

肝胆膵 88 ( 5 ) 605 - 611 2024.5 （ ISSN:0389-4991 ）

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J-GLOBAL

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奈良宣言（ALT over 30）のMASLD（metabolic dysfunction-associated steatotic liver disease）における臨床的意義の検証

川中美和, 藤井英樹, 岩城慶大, 林秀樹, 豊田秀徳, 大枝敏, 兵庫秀幸, 森下朝洋, 宗景玄祐, 川田一仁, 堤翼, 澤田康司, 前城達次, 飛田博史, 吉田雄一, 内藤雅文, 荒木亜寿香, 新垣伸吾, 川口巧, 則武秀尚, 小野正文, 正木勉, 安田諭, 冨田栄一, 米田正人, 徳重明央, 鎌田佳宏, 高橋宏和, 植田真一郎, 相島慎一, 角田圭雄, 岡上武, 中島淳, Japan Study Group of Nonalcoholic Fatty Liver Disease(JSG-NAFLD)

肝臓 2024.4

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DOI： 10.2957/kanzo.65.186
Validation study of age‐independent fibrosis score (Fibrosis‐3 index) in patients with metabolic dysfunction‐associated steatotic liver disease Reviewed

2024.4

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Abstract

Background and Aims

Because the accuracy of the Fibrosis‐4 (FIB‐4) index for predicting liver fibrosis changes with age, the need for different cut‐offs in various age groups has frequently been discussed. We developed the age‐independent score, the Fibrosis‐3 (FIB‐3) index, and have shown its usefulness in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). This study aimed to validate the diagnostic ability of the FIB‐3 index to predict fibrosis progression using a large new patient cohort.

Methods

The ability of the FIB‐3 index to predict liver fibrosis was analyzed by comparing it with that of the FIB‐4 index using data from 1398 patients with MASLD enrolled in the Asia‐based clinical outcome NAFLD study.

Results

The areas under the receiver operating characteristic curves for predicting fibrosis stage F3 or higher were not different between the FIB‐3 and FIB‐4 indices in the entire cohort. Using the single ideal cut‐offs of the indices (3.41 for FIB‐3 index and 2.01 for FIB‐4 index), the predictive accuracy of the FIB‐3 index was not significantly different from that of the FIB‐4 index among patients aged <60 years; however, the accuracy of the FIB‐3 index was significantly higher than that of the FIB‐4 index in those aged ≥60 years (0.645 and 0.529, respectively; p < 0.0001).

Conclusion

The high ability of the FIB‐3 index with a single cut‐off to predict liver fibrosis in patients with MASLD was confirmed. The FIB‐3 index could serve as a useful tool for assessing liver fibrosis regardless of age.

DOI： 10.1111/hepr.14039
Accuracy of the Enhanced Liver Fibrosis Test in Patients With Type 2 Diabetes Mellitus and Its Clinical Implications

Taeang Arai, Hirokazu Takahashi, Yuya Seko, Hidenori Toyoda, Hideki Hayashi, Kanji Yamaguchi, Michihiro Iwaki, Masato Yoneda, Toshihide Shima, Hideki Fujii, Asahiro Morishita, Kazuhito Kawata, Kengo Tomita, Miwa Kawanaka, Yuichi Yoshida, Tadashi Ikegami, Kazuo Notsumata, Satoshi Oeda, Masanori Atsukawa, Yoshihiro Kamada, Yoshio Sumida, Hideaki Fukushima, Eiji Miyoshi, Shinichi Aishima, Takeshi Okanoue, Yoshito Itoh, Atsushi Nakajima

Clinical Gastroenterology and Hepatology 2024.4

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DOI： 10.1016/j.cgh.2023.11.022
Hepatic inflammation and fibrosis are profiles related to mid‐term mortality in biopsy‐proven MASLD: A multicenter study in Japan Reviewed

2024.4

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Summary

Aims

A multi‐stakeholder consensus has proposed MASLD (metabolic dysfunction‐associated steatotic liver disease). We aimed to investigate the pathological findings related to the mid‐term mortality of patients with biopsy‐proven MASLD in Japan.

Methods

We enrolled 1349 patients with biopsy‐proven MASLD. The observational period was 8010 person years. We evaluated independent factors associated with mortality in patients with MASLD by Cox regression analysis. We also investigated pathological profiles related to mortality in patients with MASLD using data‐mining analysis.

Results

The prevalence of MASH and stage 3/4 fibrosis was observed in 65.6% and 17.4%, respectively. Forty‐five patients with MASLD died. Of these, liver‐related events were the most common cause at 40% (n = 18), followed by extrahepatic malignancies at 26.7% (n = 12). Grade 2/3 lobular inflammation and stage 3/4 fibrosis had a 1.9‐fold and 1.8‐fold risk of mortality, respectively. In the decision‐tree analysis, the profiles with the worst prognosis were characterised by Grade 2/3 hepatic inflammation, along with advanced ballooning (grade 1/2) and fibrosis (stage 3/4). This profile showed a mortality at 8.3%. Furthermore, the random forest analysis identified that hepatic fibrosis and inflammation were the first and second responsible factors for the mid‐term prognosis of patients with MASLD.

Conclusions

In patients with biopsy‐proven MASLD, the prevalence of MASH and advanced fibrosis was approximately 65% and 20%, respectively. The leading cause of mortality was liver‐related events. Hepatic inflammation and fibrosis were significant factors influencing mid‐term mortality. These findings highlight the importance of targeting inflammation and fibrosis in the management of patients with MASLD.

DOI： 10.1111/apt.17995
Interobserver agreement of pathologic classification and grading of tumoral intraductal pre-invasive neoplasms of the bile duct Reviewed

Yasuni Nakanuma, Yasunori Sato, Yuko Kakuda, Yoshiki Naito, Yuki Fukumura, Mana Fukushima, Hiroshi Minato, Shinichi Aishima, Nobuyuki Ohike, Toru Furukawa

Annals of Diagnostic Pathology 2024.4

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DOI： 10.1016/j.anndiagpath.2023.152247
Novel method for classification of prion diseases by detecting PrP ^res signal patterns from formalin-fixed paraffin-embedded samples Reviewed

Sachiko Koyama, Kaoru Yagita, Hideomi Hamasaki, Hideko Noguchi, Masahiro Shijo, Kosuke Matsuzono, Kei-Ichiro Takase, Keita Kai, Shin-Ichi Aishima, Kyoko Itoh, Toshiharu Ninomiya, Naokazu Sasagasako, Hiroyuki Honda

Prion 2024.4

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DOI： 10.1080/19336896.2024.2337981
Prognosis of biopsy-confirmed metabolic dysfunction- associated steatotic liver disease: A sub-analysis of the CLIONE study Reviewed

Michihiro Iwaki, Hideki Fujii, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue

Clinical and Molecular Hepatology 2024.4

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DOI： 10.3350/cmh.2023.0515
A rare case of liver regenerative and non-neoplastic lesion resembling a well-differentiated hepatocellular carcinoma Reviewed

Kosuke Hirose, Takeo Toshima, Taro Tobo, Satohiro Kai, Masakazu Hirakawa, Satoshi Higuchi, Takashi Ofuchi, Kiyotaka Hosoda, Yusuke Yonemura, Yuichi Hisamatsu, Takaaki Masuda, Shinichi Aishima, Koshi Mimori

Surgical Case Reports 2024.2

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DOI： 10.1186/s40792-024-01820-1
胆道系疾患の病理

相島慎一

日本病理学会会誌 113 ( 1 ) 259 - 259 2024.2 （ ISSN:0300-9181 ）

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CTを契機に発見された消化管AL型アミロイドーシスの一例

西田大輝, 芥川剛至, 藤田真衣, 沖井詩織, 水田優実, 島村拓弥, 行元崇浩, 相島慎一, 江崎幹宏

日本消化管学会雑誌 8 ( Suppl. ) 376 - 376 2024.1 （ ISSN:2433-3840 eISSN:2435-8967 ）

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肝胆道領域の病理診断

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日本臨床細胞学会雑誌 2023.10

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増大号｢胃と腸｣式読影問題集2023 応用と発展-考える画像診断が身につく全消化管 3 Cases Case 3

芥川剛至, 沖井詩織, 島村拓弥, 相島慎一, 江﨑幹宏

胃と腸 58 ( 10 ) 1434 - 1437 2023.10 （ ISSN:0536-2180 eISSN:1882-1219 ）

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DOI： 10.11477/mf.1403203389

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【「胃と腸」式読影問題集2023 応用と発展-考える画像診断が身につく】全消化管(Case 3)

芥川剛至, 沖井詩織, 島村拓弥, 相島慎一, 江崎幹宏

胃と腸 58 ( 10 ) 1434 - 1437 2023.10 （ ISSN:0536-2180 ）

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肝胆道領域の病理診断

相島慎一

日本臨床細胞学会雑誌 62 ( Suppl.2 ) 409 - 409 2023.10 （ ISSN:0387-1193 eISSN:1882-7233 ）

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【膵癌・胆道癌2023(下)胆道癌編-基礎・臨床の最新研究動向-】特殊な組織型(臨床病理学的特徴)AFP産生腫瘍

山下洋市, 相島慎一, 黒田陽介, 栗原健

日本臨床 81 ( 増刊4 膵癌・胆道癌2023(下)胆道癌編 ) 311 - 315 2023.4 （ ISSN:0047-1852 ）

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A Case of Intramural Cystic Lesion of the Gallbladder with Low-grade Atypical Mucinous Epithelium

SUGIU Kumi, MURATA Toshihiro, KAWAMATA Osamu, IMADA Takako, MAKABE Mikio, AISHIMA Shinichi

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 84 ( 5 ) 820 - 824 2023 （ ISSN:1345-2843 eISSN:1882-5133 ）

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A 71-year-old man who had been pointed out having gallstone was diagnosed with cholelithiasis and adenomyomatosis by preoperative abdominal MRI. Laparoscopic cholecystectomy was performed. The resected specimen included a 25-mm submucosal tumor-like ridging that was found to be a multilocular cystic lesion on the section. Histopathology disclosed adenmyomatosis and multilocular cystic lesion due to mucinous epithelium localized in the gallbladder wall. The cystic epithelium was partly positive for MUC5AC and MCU6, that characterized of gastric-type mucus, with a part comprising low-grade atypical epithelium. Our case was of an intramurally growing cystic lesion localized in the gallbladder wall. Morphologically, it is designated as intramural multicystic mucinous neoplasm with low-grade intraepithelial neoplasia. Due to the rarity of pathological features, we here present this case.

DOI： 10.3919/jjsa.84.820

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Other Link： https://www.jstage.jst.go.jp/article/jjsa/84/5/84_820/_pdf
増殖因子を固定化したgel-in-oil(G/O)の経皮投与による紫外線B誘発皮膚障害の予防・修復効果

張怡, 井上雄太, FARDOUS Jannatul, 土井亨太, 井嶋隆博, 藤淵俊王, 山下洋市, 相島慎一, 井嶋博之

日本再生医療学会総会(Web) 22nd 2023

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STAT6陽性,S-100陽性,Melan A陽性を示す間葉系髄内腫瘍の一例

中原由紀子, 伊藤寛, 並川裕貴, 増岡淳, 甲斐敬太, 相島慎一, 阿部竜也

Brain Tumor Pathology. Supplement 40 2023

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Gerstmann-Straussler-Scheinker diseaseにおけるresident microgliaの挙動

本田裕之, 本田裕之, 野口英子, 野上健一郎, 渡邉暁博, 栄信孝, 荒畑創, 河野祐治, 山本明史, 甲斐敬太, 相島慎一, 笹ヶ迫直一

国立病院総合医学会(Web) 77th 2023

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カボザンチニブ投与後に肝細胞癌腫瘍内出血を来した1例

森美哉子, 桑代卓也, 湯ノ谷修三, 川添夕佳, 田中賢一, 井上香, 磯田広史, 大枝敏, 秋山巧, 江頭秀哲, 相島慎一, 高橋宏和

日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集 121st-115th 2023

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外科切除検体を用いた画像解析ソフトによる肝細胞癌と肝内胆管癌の細胞学的比較検討

北村捷, 甲斐敬太, 中村光男, 田中智和, 井手貴雄, 能城浩和, 末岡榮三朗, 相島慎一, 相島慎一

日本臨床細胞学会雑誌(Web) 62 2023 （ ISSN:1882-7233 ）

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涙腺多形腺腫の1例

本吉郁哉, 北村捷, 甲斐敬太, 並川裕貴, 前田佐知子, 橋口真理子, 上瀧さやか, 吉岡史隆, 相島慎一, 相島慎一, 末岡榮三朗

日本臨床細胞学会雑誌(Web) 62 2023 （ ISSN:1882-7233 ）

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α-Fetoprotein-producing tumor

山下洋市, 相島慎一, 黒田陽介, 栗原健

日本臨床 81 2023 （ ISSN:0047-1852 ）

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肝病変に対する線維化の病理学的評価

相島慎一

Japanese Journal of Diagnostic Imaging 41 ( 増刊 ) 68 - 68 2023 （ ISSN:2187-266X ）

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肝胆道領域の病理診断

相島慎一

日本臨床細胞学会雑誌(Web) 62 2023 （ ISSN:1882-7233 ）

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【超音波elastographyによる非アルコール性脂肪性肝疾患/非アルコール性脂肪性肝炎の診断と評価】非アルコール脂肪肝疾患と非アルコール性脂肪肝炎の病理組織所見

鹿毛政義, 相島慎一, 草野弘宣, 矢野博久

超音波医学 49 ( 5 ) 427 - 432 2022.9 （ ISSN:1346-1176 ）

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非アルコール性脂肪肝疾患(nonalcoholic fatty liver disease:NAFLD)とは臨床所見に加え病理学的形態学の概念に基づくもので,大きく非アルコール性脂肪肝(nonalcoholic fatty liver:NAFL)と非アルコール性脂肪性肝炎(nonalcoholic steatohepatitis:NASH)に分類される.NASHは肝硬変や肝細胞癌へと進行する可能性があるので,NAFLとNASHの鑑別診断は重要である.NAFLは肝細胞の傷害を伴わない単純な脂肪肝であるが,NASHは主に小葉中心帯領域(ゾーン3)に分布する大滴性脂肪変性,炎症,風船様肝細胞が特徴である.肝生検はNAFLDを診断する上で有用な検査であるが侵襲的である.ゆえに,診断画像法を含むさまざまな非侵襲性手法が近年開発されている.NAFLDにおける画像診断の有用性を検証するためには,画像診断と組織病理学的所見は密接に関連しているので,病理組織所見が画像所見にどのように反映されているのかを明らかにする必要がある.ここでは,NAFLDの主な病理学的所見,すなわち肝細胞の脂肪変性,炎症,風船様肝細胞,Mallory-Denk体,線維化について概説し,肝硬変への進行過程についても説明を加えた.(著者抄録)
左室瘤に対してmultimodality imagingアプローチを用いた冠動脈の閉塞を伴わない心筋梗塞患者の1例(Multimodality Imaging Approach for a Left Ventricular Aneurysm in a Patient With Myocardial Infarction and Non-Obstructive Coronary Arteries)

Yoshioka Goro, Sonoda Shinjo, Aishima Shinichi, Node Koichi

Circulation Journal 86 ( 10 ) 1586 - 1586 2022.9 （ ISSN:1346-9843 ）

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【非腫瘍性肝疾患-肝生検診断のポイント-】消化管病変に関連する肝胆道病変

相島慎一

病理と臨床 40 ( 8 ) 0792 - 0795 2022.8 （ ISSN:0287-3745 ）

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当院における下咽頭表在癌に対する消化器・耳鼻科合同治療の現状

芥川剛至, 石田知也, 下田良, 相島慎一, 江崎幹宏

日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集 120th-114th (CD-ROM) 2022

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心房細動患者における心房拡大と関連する病理組織学的因子~心房心筋生検200例の検討~

高橋佑弥, 山口尊則, 大坪豊和, 中島夏奈, 新里広大, 大迫亮介, 野出孝一, 福井暁, 廣田慧, 高橋尚彦, 川口淳, 相島慎一

心臓 54 ( Supplement 1 ) 2022 （ ISSN:0586-4488 ）

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Histological determinants of Atrial Bipolar Voltage in Patients with Atrial Fibrillation

高橋佑弥, 高橋佑弥, 山口尊則, 山口尊則, 大坪豊和, 大坪豊和, 中島夏奈, 新里広大, 大迫亮介, 七田茂樹, 河野佑貴, 福井暁, 川口淳, 相島慎一, 高橋尚彦, 野出孝一

日本心臓病学会学術集会(Web) 70th 2022

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Application development of decellularized tissue

井嶋博之, 呉帆き, 福田有嘉子, 小柳和也, 趙宰庸, 堺裕輔, 宮田辰徳, 中尾陽佑, 山尾宣暢, 相島慎一, 山下洋市, 馬場秀夫

日本再生医療学会総会(Web) 21st 2022

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非腫瘍性肝疾患-肝生検診断のポイント-消化管病変に関連する肝胆道病変

相島慎一

病理と臨床 40 ( 8 ) 2022 （ ISSN:0287-3745 ）

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Perry病同一家系3症例(DCTN1 F52L変異)の臨床病理学的検討

本田裕之, 笹ヶ迫直一, 原英夫, 三嶋崇靖, 濱崎英臣, 吉村基, 八木田薫, 栄信孝, 相島慎一, 坪井義夫, 岩城徹

日本神経学会学術大会プログラム・抄録集 63rd 2022

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リンパ管拡張様所見を呈した食道胃接合部癌の十二指腸転移の一例

中村啓太, 芥川剛至, 行元崇浩, 松尾真紀子, 井上須磨, 島村拓弥, 佐野晴彦, 勝屋弘雄, 前田佐知子, 相島慎一, 木村晋也, 江崎幹宏

日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集 120th-114th (CD-ROM) 2022

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前立腺Mucinous adenocarcinomaの一例

藤木和也, 山口健, 福井修一, 中園貴彦, 有働和馬, 野口満, 花島克幸, 相島慎一, 入江裕之

断層映像研究会雑誌(Web) 49 ( 1 ) 2022 （ ISSN:2187-0489 ）

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A case of giant hepatic cyst showing reactive mesothelial cells with atypia in the cyst fluid.

北村捷, 北村捷, 甲斐敬太, 田中智和, 井手貴雄, 上瀧さやか, 能城浩和, 末岡榮三朗, 相島慎一, 相島慎一

日本臨床細胞学会九州連合会雑誌 53 2022 （ ISSN:0912-6600 ）

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Central nervous system involvement of graft versus host disease after allogeneic hematopoietic stem cell transplantation for adult T cell leukemia

井手俊宏, 飯田紘太郎, 勝屋弘雄, 伊藤寛, 相島慎一, 原英夫

臨床神経学(Web) 62 ( 1 ) 2022 （ ISSN:1882-0654 ）

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Central nervous system involvement of graft versus host disease after allogeneic hematopoietic stem cell transplantation for adult T cell leukemia Reviewed

Toshihiro Ide, Kotaro Iida, Hiroo Katsuya, Hiroshi Ito, Shinichi Aishima, Hideo Hara

Rinsho Shinkeigaku 62 ( 1 ) 33 - 38 2022 （ ISSN:0009-918X eISSN:1882-0654 ）

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A 54-year-old woman was diagnosed with acute adult T-cell leukemia (ATL) in November 2015 and underwent allogeneic hematopoietic stem cell transplantation in March 2016. Cognitive impairment appeared suddenly around May 2019, and MRI of the brain showed cerebral white matter lesions. Cerebrospinal fluid examination showed no significant findings other than elevated protein. Brain biopsy showed inflammatory cells, (mainly CD8-positive T lymphocytes), infiltrating the white matter. Based on the pathological findings and the history of chronic graft versus host disease (GVHD) in the lungs and intestines, we diagnosed central nervous system involvement of GVHD (CNS-GVHD). Immunotherapy with steroids and mycophenolate mofetil resulted in improvement of the cognitive dysfunction and inflammatory findings in the spinal fluid. This case is the first report of CNS-GVHD in ATL, suggesting the importance of diagnosis by brain biopsy and the efficacy of immunotherapy.

DOI： 10.5692/clinicalneurol.cn-001665

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超短期間のレンバチニブ投与で抗腫瘍効果に差異を認めた肝細胞癌の一例

木塚雅之, 福本一樹, 木村俊一郎, 田中賢一, 桑代卓也, 秋山巧, 相島慎一, 安西慶三, 高橋宏和

肝臓 63 ( Supplement 1 ) 2022 （ ISSN:0451-4203 ）

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Histopathological findings of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

KAGE Masayoshi, AISHIMA Shinichi, KUSANO Hironori, YANO Hirohisa

Choonpa Igaku 49 ( 5 ) 427 - 432 2022 （ ISSN:1346-1176 eISSN:1881-9311 ）

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Nonalcoholic fatty liver disease (NAFLD) is based on the concept of pathological morphology as well as clinical findings, and is broadly categorized into nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). The differential diagnosis between NAFL and NASH is important because NASH has the potential to progress to cirrhosis and hepatocellular carcinoma. NAFL is simple hepatic steatosis without hepatocellular injury, while NASH is characterized by macrovesicular steatosis, inflammation, and ballooning hepatocytes with a predominantly centrilobular (zone 3) distribution. Liver biopsy is a useful test for diagnosing NAFLD, but it is invasive. Therefore, various noninvasive methods including diagnostic imaging have been developed in recent years. To verify their usefulness, it is necessary to clarify in detail how the pathological findings are reflected in the image findings as imaging and histopathological findings are closely related. We describe the main histological features of NAFLD, i.e., steatosis, inflammation, ballooning hepatocytes, Mallory-Denk bodies, and fibrosis, as well as the evolutional process to liver cirrhosis.

DOI： 10.3179/jjmu.jjmu.r.204

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鼻尖部偽リンパ腫として治療中に,口唇や眼瞼に結節を生じた粘膜関連リンパ組織節外性辺縁帯リンパ腫

岡莉恵, 井上卓也, 西純平, 相島慎一, 大島孝一, 永瀬浩太郎, 杉田和成

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 38th 2022

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胆道上皮内腫瘍と細胞診をめぐる問題胆道上皮内腫瘍の概念と病理

相島慎一

日本臨床細胞学会雑誌 2021.10

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自己免疫性溶血性貧血を合併した原発性胆汁性胆管炎の2例

道免和文, 山本洋, 山本麻太郎, 小野原伸也, 相島慎一, 下田慎治

肝臓 2021.2

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1例目は71歳，女性．動悸を主訴に当科を紹介受診した．血色素7.7 g/dl，ハプトグロビン10 mg/dl以下，Coombs試験陽性から自己免疫性溶血性貧血（AIHA）と診断された．プレドニゾロン（prednisolone，PSL）投与が著効したが，AIHAの診断後1年8カ月経過した頃よりALP，γGTPの上昇ならびに抗ミトコンドリアM2抗体の高値を示し，肝組織検査で中沼分類stage 2の原発性胆汁性胆管炎（PBC）と診断された．2例目は67歳，男性．褐色尿を主訴に当科を紹介受診した．血色素が10.3 g/dl，ハプトグロビンが10 mg/dl以下，Coombs試験が陽性であり，AIHAと診断された．1例目同様にPSLが著効したが，初診時からの持続的なALP，γGTPの上昇ならびに抗ミトコンドリアM2抗体の高値を示し，肝組織検査で中沼分類stage 2のPBCと診断された．2症例ともにウルソデオキシコール酸が奏効し，肝胆道系酵素は正常化した．自己免疫性疾患であるPBC，AIHAの合併例は稀であり，発症機序，治療について考察した．

DOI： 10.2957/kanzo.62.144
Histopathological findings of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Masayoshi Kage, Shinichi Aishima, Hironori Kusano, Hirohisa Yano

Journal of medical ultrasonics (2001) 2020.10

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DOI： 10.1007/s10396-020-01061-3
Decrease in fasting insulin secretory function correlates with significant liver fibrosis in Japanese non-alcoholic fatty liver disease patients.

Norimasa Araki, Hirokazu Takahashi, Ayako Takamori, Yoichiro Kitajima, Hideyuki Hyogo, Yoshio Sumida, Saiyu Tanaka, Keizo Anzai, Shinichi Aishima, Kazuaki Chayama, Kazuma Fujimoto, Yuichiro Eguchi

JGH open : an open access journal of gastroenterology and hepatology 2020.10

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DOI： 10.1002/jgh3.12367
Guidance for diagnosing autoimmune pancreatitis with biopsy tissues.

Kenji Notohara, Terumi Kamisawa, Noriyoshi Fukushima, Toru Furukawa, Takuma Tajiri, Hiroshi Yamaguchi, Shinichi Aishima, Yuki Fukumura, Kenichi Hirabayashi, Eisuke Iwasaki, Atsushi Kanno, Satomi Kasashima, Atsuhiro Kawashima, Motohiro Kojima, Kensuke Kubota, Yasuhiro Kuraishi, Tomoko Mitsuhashi, Yoshiki Naito, Itaru Naitoh, Hiroshi Nakase, Takayoshi Nishino, Nobuyuki Ohike, Junichi Sakagami, Kyoko Shimizu, Masahiro Shiokawa, Takeshi Uehara, Tsukasa Ikeura, Shigeyuki Kawa, Kazuichi Okazaki

Pathology international 2020.10

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DOI： 10.1111/pin.12994
Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study.

Yuji Ogawa, Takashi Kobayashi, Yasushi Honda, Takaomi Kessoku, Wataru Tomeno, Kento Imajo, Takashi Nakahara, Satoshi Oeda, Yuko Nagaoki, Yuichiro Amano, Tatsuya Ando, Megumi Hirayama, Osamu Isono, Hidenori Kamiguchi, Hiroshi Nagabukuro, Shinji Ogawa, Yoshinori Satomi, Yusuke Saigusa, Hirokazu Takahashi, Hideyuki Hyogo, Masato Yoneda, Satoru Saito, Takeharu Yamanaka, Shinichi Aishima, Yuichiro Eguchi, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakajima

Hepatology research : the official journal of the Japan Society of Hepatology 2020.8

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DOI： 10.1111/hepr.13528
Diagnostic accuracy of FibroScan-AST score to identify non-alcoholic steatohepatitis with significant activity and fibrosis in Japanese patients with non-alcoholic fatty liver disease: Comparison between M and XL probes.

Satoshi Oeda, Hirokazu Takahashi, Kento Imajo, Yuya Seko, Takashi Kobayashi, Yuji Ogawa, Michihisa Moriguchi, Masato Yoneda, Keizo Anzai, Hiroyuki Irie, Eisaburo Sueoka, Shinichi Aishima, Masayoshi Kage, Yoshito Itoh, Yuichiro Eguchi, Atsushi Nakajima

Hepatology research : the official journal of the Japan Society of Hepatology 2020.7

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DOI： 10.1111/hepr.13508
Clinicopathological characteristics of combined hepatocellular cholangiocarcinoma from the viewpoint of patient prognosis after hepatic resection: High rate of early recurrence and its predictors.

Yo-Ichi Yamashita, Shinichi Aishima, Yosuke Nakao, Tomoharu Yoshizumi, Hiroaki Nagano, Tamotsu Kuroki, Yuko Takami, Takao Ide, Masayuki Ohta, Mitsuhisa Takatsuki, Atsushi Nanashima, Fuminori Ishii, Kenji Kitahara, Satoshi Iino, Toru Beppu, Hideo Baba, Susumu Eguchi

Hepatology research : the official journal of the Japan Society of Hepatology 2020.7

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DOI： 10.1111/hepr.13507
Discordant pathological diagnosis of non-alcoholic fatty liver disease: A prospective multicenter study.

Takuya Kuwashiro, Hirokazu Takahashi, Hideyuki Hyogo, Yuji Ogawa, Kento Imajo, Masato Yoneda, Takashi Nakahara, Satoshi Oeda, Kenichi Tanaka, Yuichiro Amano, Shinji Ogawa, Atsushi Kawaguchi, Shinichi Aishima, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakajima, Yuichiro Eguchi

JGH open : an open access journal of gastroenterology and hepatology 2020.6

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DOI： 10.1002/jgh3.12289
Accuracy of the Enhanced Liver Fibrosis test, and combination of the Enhanced Liver Fibrosis and non-invasive tests for the diagnosis of advanced liver fibrosis in patients with non-alcoholic fatty liver disease.

Chika Inadomi, Hirokazu Takahashi, Yuji Ogawa, Satoshi Oeda, Kento Imajo, Yoshihito Kubotsu, Kenichi Tanaka, Takaomi Kessoku, Michiaki Okada, Hiroshi Isoda, Takumi Akiyama, Hideaki Fukushima, Masato Yoneda, Keizo Anzai, Shinichi Aishima, Atsushi Nakajima, Yuichiro Eguchi

Hepatology research : the official journal of the Japan Society of Hepatology 2020.6

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DOI： 10.1111/hepr.13495
Unclassified hepatocellular adenoma with histological brown pigment deposition and serum PIVKA-II level elevation: a case report.

Kouki Hoshino, Norifumi Harimoto, Ryo Muranushi, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Ran Tomomasa, Sumihito Nobusawa, Shinichi Aishima, Osamu Nakashima, Ken Shirabe

Surgical case reports 2020.5

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DOI： 10.1186/s40792-020-00853-6
Accuracy of liver stiffness measurement and controlled attenuation parameter using FibroScan® M/XL probes to diagnose liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease: a multicenter prospective study.

2020.4

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BACKGROUND: Few studies have evaluated both liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease (NAFLD) using both FibroScan® M and XL probes. This study was performed to investigate the accuracy of both FibroScan® probes to diagnose liver fibrosis and steatosis in patients with NAFLD. METHODS: We prospectively enrolled 137 consecutive patients with clinically suspected NAFLD in our joint-research facilities. Liver biopsies, liver stiffness measurements (LSMs), and controlled attenuation parameter (CAP) measurements were performed, and 122 patients with NAFLD diagnosed pathologically by central pathologists were included in the final analysis. RESULTS: Reliable LSM results were obtained in 85.2% (M) and 89.3% (XL) of patients, and CAP was reliable in 90.2% (M) and 90.2% (XL). The median LSM was significantly lower with the XL than M probe, and CAP was significantly higher with the XL than M probe. The optimal cut-off values for diagnosing the fibrosis stage were lower for LSM with the XL than M probe (stage ≥ 2, 6.7 vs. 7.0; stage ≥ 3, 8.2 vs. 10.8; stage 4, 14.3 vs. 16.8, respectively), whereas those of CAP were higher for the XL than M probe (score of ≥ 2, 273 vs. 267; score of 3, 302 vs. 286, respectively). There were no significant differences in accuracy of the LSM and CAP between the probes. CONCLUSIONS: Liver fibrosis and steatosis could be equally evaluated with FibroScan® M and XL probes in patients with NAFLD. There was no significant difference in diagnostic accuracy between the two probes using probe-specific cut-off values.

DOI： 10.1007/s00535-019-01635-0
Accumulation of Astrocytic Aquaporin 4 and Aquaporin 1 in Prion Protein Plaques.

Shoko Sadashima, Hiroyuki Honda, Satoshi O Suzuki, Masahiro Shijo, Shinichi Aishima, Keita Kai, Junichi Kira, Toru Iwaki

Journal of neuropathology and experimental neurology 2020.4

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DOI： 10.1093/jnen/nlaa010
Fairly rare small-diameter hepatocellular carcinoma with right adrenal gland metastasis having an inferior vena cava tumor thrombus: a case report.

Takamichi Igarashi, Norifumi Harimoto, Nozomi Matsumura, Masaya Sugiyama, Kenichiro Araki, Takehiko Yokobori, Takashi Kosone, Hitoshi Takagi, Shinichi Aishima, Hideaki Yokoo, Ken Shirabe

Surgical case reports 2019.11

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DOI： 10.1186/s40792-019-0705-7
Decreased cytokeratin 7 expression correlates with the progression of cervical squamous cell carcinoma and poor patient outcomes.

Mariko Hashiguchi, Masanori Masuda, Keita Kai, Yoshifumi Nakao, Atsushi Kawaguchi, Masatoshi Yokoyama, Shinichi Aishima

The journal of obstetrics and gynaecology research 2019.11

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DOI： 10.1111/jog.14108
Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases.

Hiroyuki Honda, Masaki Matsumoto, Masahiro Shijo, Hideomi Hamasaki, Shoko Sadashima, Satoshi O Suzuki, Shinichi Aishima, Keita Kai, Keiichi I Nakayama, Naokazu Sasagasako, Toru Iwaki

Journal of neuropathology and experimental neurology 2019.10

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DOI： 10.1093/jnen/nlz075
A unique autopsy case of ascending aortic dissection caused by giant cell arteritis without drug therapy.

Yukari Takase, Yosuke Murakami, Jumpei Nishi, Osamu Tokunaga, Toshiharu Matsumoto, Shinichi Aishima

Pathology international 2019.10

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DOI： 10.1111/pin.12845
CXCL12 expression in intrahepatic cholangiocarcinoma is associated with metastasis and poor prognosis.

Tatsunori Miyata, Yo-Ichi Yamashita, Tomoharu Yoshizumi, Masayuki Shiraishi, Masayuki Ohta, Susumu Eguchi, Shinichi Aishima, Hikaru Fujioka, Hideo Baba

Cancer science 2019.10

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DOI： 10.1111/cas.14151
IFN-γ Promotes Epithelial-Mesenchymal Transition and the Expression of PD-L1 in Pancreatic Cancer.

2019.8

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BACKGROUND: Tumor immune reactions not only provide host defense but also accelerate tumor immune escape and phenotype switching. Here, we examined the association of programmed cell death ligand 1 (PD-L1) expression with epithelial-mesenchymal transition (EMT)-associated markers in pancreatic ductal adenocarcinoma (PDA) within the context of the tumor microenvironment. MATERIALS AND METHODS: PDA samples from 36 patients were analyzed for PD-L1, vimentin, E-cadherin, and Snail expressions and for PDA cell and immune cell infiltration. PD-L1 expression and EMT in PDA cell lines under conditions of altering interferon gamma (IFN-γ) signals were also assessed. RESULTS: Immunohistochemistry revealed a significant correlation between vimentin and PD-L1 expression, whereas double staining showed them to be simultaneously expressed by PDA cells. Positive vimentin expression was associated with the infiltration of a lower number of CD8+ T cells and a higher number of FoxP3+ cells and poor patient prognosis (P = 0.03). PDA tumor cells promoted PD-L1 expression and EMT under the presence of IFN-γ, which was inhibited by the signal transducer and activator of transcription (STAT)1 small interfering RNA. CONCLUSIONS: Strong correlations were observed between PD-L1 expression, EMT, and the immunosuppressive tumor microenvironment. Targeting STAT1 combined with PD-1/PD-L1 immunotherapy may improve outcomes for patients with PDA.

DOI： 10.1016/j.jss.2019.02.038
Transferrin receptor 1 overexpression is associated with tumour de-differentiation and acts as a potential prognostic indicator of hepatocellular carcinoma.

Makiko Adachi, Keita Kai, Koutaro Yamaji, Takao Ide, Hirokazu Noshiro, Atsushi Kawaguchi, Shinichi Aishima

Histopathology 2019.7

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DOI： 10.1111/his.13847
Primary mucoepidermoid carcinoma of the liver with CRTC1-MAML2 fusion: a case report.

Jiro Watanabe, Keita Kai, Ken Tanikawa, Mamoru Hiraki, Naohisa Mizukami, Shinichi Aishima, Takafumi Nakano, Hidetaka Yamamoto

Diagnostic pathology 2019.7

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DOI： 10.1186/s13000-019-0863-8
高齢男性に急性発症した自己免疫性肝炎の1例

鮎川周平, 道免和文, 小野原伸也, 相島慎一

臨牀と研究 = The Japanese journal of clinical and experimental medicine 2019.2

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Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation.

Keiichiro Okuyama, Yoshihiko Kitajima, Noriyuki Egawa, Hiroshi Kitagawa, Kotaro Ito, Shinichi Aishima, Kazuyoshi Yanagihara, Tomokazu Tanaka, Hirokazu Noshiro

Scientific reports 2019.2

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DOI： 10.1038/s41598-019-39563-x
External validation of ADNEX MR SCORING system: a single-centre retrospective study

K. Sasaguri, K. Yamaguchi, T. Nakazono, M. Mizuguchi, S. Aishima, M. Yokoyama, H. Irie

Clinical Radiology 2019.2

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DOI： 10.1016/j.crad.2018.10.014
Formalin fixation on HER-2 and PD-L1 expression in gastric cancer: A pilot analysis using the same surgical specimens with different fixation times.

Keita Kai, Yukie Yoda, Atsushi Kawaguchi, Akimichi Minesaki, Hironori Iwasaki, Shinichi Aishima, Hirokazu Noshiro

World journal of clinical cases 2019.2

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DOI： 10.12998/wjcc.v7.i4.419
Occult HBV infection status and its impact on surgical outcomes in patients with curative resection for HCV-associated hepatocellular carcinoma.

Koutaro Yamaji, Keita Kai, Sho Komukai, Hiroki Koga, Takao Ide, Atsushi Kawaguchi, Hirokazu Noshiro, Shinichi Aishima

Hepatobiliary surgery and nutrition 2018.12

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DOI： 10.21037/hbsn.2018.10.01
Primary intrahepatic cholangiocarcinoma with sarcomatous stroma: case report and review of the literature.

Kyohei Yugawa, Tomoharu Yoshizumi, Yohei Mano, Noboru Harada, Shinji Itoh, Toru Ikegami, Yuji Soejima, Nobuhiro Fujita, Kenichi Kohashi, Shinichi Aishima, Yoshinao Oda, Masaki Mori

Surgical case reports 2018.11

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DOI： 10.1186/s40792-018-0543-z
肝胆道系疾患における細胞診の役割肝胆道疾患病理に期待されること

相島慎一

日本臨床細胞学会雑誌 2018.10

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画像診断と病理肝内胆管癌肝内胆管癌の病理

相島慎一

肝臓クリニカルアップデート / 肝臓クリニカルアップデート編集委員会編 2018.10

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Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide.

Toshihiko Ando, Kensuke Kojima, Haruhiko Sano, Keisuke Kidoguchi, Kana Kusaba, Mariko Yoshimura, Masako Yokoo, Yasushi Kubota, Hideaki Nakamura, Yukari Takase, Shinichi Aishima, Shinya Kimura

Leukemia & lymphoma 2018.10

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DOI： 10.1080/10428194.2018.1427859
A case report of intracholecystic papillary neoplasm of the gallbladder resembling a submucosal tumor.

Ryo Muranushi, Hideyuki Saito, Asuka Matsumoto, Toshihide Kato, Naritaka Tanaka, Kenji Nakazato, Nobuhiro Morinaga, Yoshinori Shitara, Masatoshi Ishizaki, Takatomo Yoshida, Shinichi Aishima, Ken Shirabe

Surgical case reports 2018.9

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DOI： 10.1186/s40792-018-0524-2
Synchronous mantle cell lymphoma and lung adenocarcinoma presenting in a pleural effusion: A rare tumour combination and a potential pitfall of cytodiagnosis

K. Kai, Y. Ryu, K. Kamochi, A. Nishioka, Y. Kubota, M. Nakamura, S. Kimura, E. Sueoka, S. Aishima

Cytopathology 2018.8

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DOI： 10.1111/cyt.12532
Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis.

Yoshihiro Aiba, Kenichi Harada, Masahiro Ito, Takashi Suematsu, Shinichi Aishima, Yuki Hitomi, Nao Nishida, Minae Kawashima, Mitsuhisa Takatsuki, Susumu Eguchi, Shinji Shimoda, Hitomi Nakamura, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Kiyoshi Migita, Hiroshi Yatsuhashi, Katsushi Tokunaga, Minoru Nakamura

Scientific reports 2018.8

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DOI： 10.1038/s41598-018-30146-w
Neuroendocrine tumor of the pancreas with rhabdoid feature.

Tetsuyuki Miyazaki, Shinichi Aishima, Minoru Fujino, Keigo Ozono, Yuichiro Kubo, Yasuhiro Ushijima, Takashi Osoegawa, Eikichi Ihara, Itou Tetsuhide, Takao Ohtsuka, Masafumi Nakamura, Yoshinao Oda

Virchows Archiv : an international journal of pathology 2018.8

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DOI： 10.1007/s00428-018-2398-x
Fairly rare clear cell adenocarcinoma mimicking liver cancer: a case report.

Norifumi Harimoto, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichirou Araki, Hayato Ikota, Masafumi Suyama, Takeshi Maki, Shinichi Aishima, Hiroyuki Kuwano, Ken Shirabe

Surgical case reports 2018.8

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DOI： 10.1186/s40792-018-0500-x
A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.

Takayuki Fujii, Ryo Yamasaki, Kyoko Iinuma, Daisuke Tsuchimoto, Yoshinori Hayashi, Ban-Yu Saitoh, Takuya Matsushita, Mizuho A Kido, Shinichi Aishima, Hiroshi Nakanishi, Yusaku Nakabeppu, Jun-Ichi Kira

Annals of neurology 2018.8

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DOI： 10.1002/ana.25279
cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.

Elizabeth Brunt, Shinichi Aishima, Pierre-Alain Clavien, Kathryn Fowler, Zachary Goodman, Gregory Gores, Annette Gouw, Alex Kagen, David Klimstra, Mina Komuta, Fukuo Kondo, Rebecca Miksad, Masayuki Nakano, Yasuni Nakanuma, Irene Ng, Valerie Paradis, Young Nyun Park, Alberto Quaglia, Massimo Roncalli, Tania Roskams, Michiie Sakamoto, Romil Saxena, Christine Sempoux, Claude Sirlin, Ashley Stueck, Swan Thung, W M S Tsui, Xin-Wei Wang, Aileen Wee, Hirohisa Yano, Matthew Yeh, Yoh Zen, Jessica Zucman-Rossi, Neil Theise

Hepatology (Baltimore, Md.) 2018.7

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DOI： 10.1002/hep.29789
Resected primary mucinous cholangiocarcinoma of the liver.

Kei Hagiwara, Kenichiro Araki, Takahiro Yamanaka, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Norifumi Harimoto, Hiroyuki Kuwano, Sumito Nobusawa, Shinichi Aishima, Ken Shirabe

Surgical case reports 2018.5

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DOI： 10.1186/s40792-018-0450-3
Microvascular invasion of single small hepatocellular carcinoma ≤3 cm: Predictors and optimal treatments.

2018.5

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BACKGROUND: Small hepatocellular carcinomas (HCC ≤3 cm) are generally considered to have low malignant potential; however, some of them display pathological microvascular invasion (MVI). METHODS: Between 1991 and 2013, 414 patients with a single HCC ≤3 cm underwent curative hepatic resection (HR). Predictors for MVI were identified. Using another cohort (149 patients during 2000-2014), our predictors for MVI in HCC ≤3 cm were validated. In 428 patients with a single HCC ≤3 cm who had predictors for MVI, survival was compared among anatomical HR (n = 149), partial HR (n = 227), and radiofrequency ablation (RFA) (n = 52). RESULTS: The positive rate of MVI reached 40.6% (168/414 patients). Independent predictors for MVI were as follows: tumor diameter ≥2 cm (odds ratio 1.84, P = .0052), alpha-fetoprotein (AFP) ≥200 ng/mL (odds ratio 1.82, P = .0466), and des-gamma-carboxy prothrombin (DCP) ≥40 mAU/mL (odds ratio 1.79, P = .0126). Matching at least one predictor among these three could predict MVI in HCC ≤3 cm well (sensitivity 82.8%, positive predictive value [PPV] 48.7%). This criterion could also predict MVI in HCC ≤3 cm well in another cohort (sensitivity 82.8%, PPV 30.3%). In patients with single HCC ≤3 cm matching our criterion for predicting MVI, anatomical HR led to significantly better survival in both disease-free (hazard ratio 0.689, P = .0231) and overall (hazard ratio 0.589, P = .0316) survivals. CONCLUSION: Matching at least one factor among three (tumor diameter ≥2 cm, AFP ≥200 ng/mL, or DCP ≥40 mAU/mL) can predict MVI in HCC ≤3 cm. In such patients, anatomical HR would be recommended to improve survival.

DOI： 10.1002/ags3.12057
A dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features.

Keita Kai, Kazuma Udo, Ken Yamaguchi, Shohei Tobu, Mitsuru Noguchi, Shinichi Aishima

Pathology international 2018.4

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DOI： 10.1111/pin.12645
Correlation between smoking habit and surgical outcomes on viral-associated hepatocellular carcinomas.

Keita Kai, Sho Komukai, Hiroki Koga, Koutaro Yamaji, Takao Ide, Atsushi Kawaguchi, Shinichi Aishima, Hirokazu Noshiro

World journal of gastroenterology 2018.1

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DOI： 10.3748/wjg.v24.i1.58
Clear Cell Carcinoma of the Uterine Cervix Presented as a Submucosal Tumor Arising in a Background of Cervical Endometriosis.

Mariko Hashiguchi, Keita Kai, Satoshi Nishiyama, Yoshifumi Nakao, Masatoshi Yokoyama, Shinichi Aishima

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2018.1

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DOI： 10.1097/PGP.0000000000000386
Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma.

Hiroki Koga, Keita Kai, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro

World journal of hepatology 2017.12

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DOI： 10.4254/wjh.v9.i35.1286
Immunoserological and histological differences between autoimmune hepatitis with acute presentation and chronic autoimmune hepatitis.

Kazufumi Dohmen, Hirofumi Tanaka, Masatora Haruno, Shinichi Aishima

Hepatology research : the official journal of the Japan Society of Hepatology 2017.12

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DOI： 10.1111/hepr.12875
Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis.

Kota Wakiyama, Yoshihiko Kitajima, Tomokazu Tanaka, Masao Kaneki, Kazuyoshi Yanagihara, Shinichi Aishima, Jun Nakamura, Hirokazu Noshiro

Scientific reports 2017.10

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DOI： 10.1038/s41598-017-12929-9
Colonic poorly differentiated adenocarcinoma with abundant cancer-associated fibroblasts diagnosed by trans-gastric endoscopic ultrasound-guided fine needle aspiration cytology

M. Yamasaki, K. Kai, A. Nomura, H. Kono, H. Kawakubo, Y. Sakata, M. Mizuguchi, S. Aishima

Cytopathology 2017.10

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DOI： 10.1111/cyt.12443
臨牀指針小腸間膜に発生した仮性腸間膜囊腫の1例

大岩俊夫, 大岩久夫, 山下裕一, 岩崎昭憲, 森田勝, 西牟田雄治, 相島慎一, 藤原美奈子, 城後友望子

臨牀と研究 = The Japanese journal of clinical and experimental medicine 2017.9

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Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report.

Norihiro Ishii, Kenichiro Araki, Takahiro Yamanaka, Tadashi Handa, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Shinichi Aishima, Hiroyuki Kuwano, Ken Shirabe

Surgical case reports 2017.9

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DOI： 10.1186/s40792-017-0377-0
Autopsy case of systemic EBV-positive T-cell lymphoma of childhood with marked hepatomegaly in a middle-aged man.

Keita Kai, Futa Koga, Norimasa Araki, Takero Shindo, Yuichiro Eguchi, Shuji Toda, Shinichi Aishima

Pathology international 2017.8

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DOI： 10.1111/pin.12549
The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer.

Daisuke Imai, Tomoharu Yoshizumi, Shinji Okano, Hideaki Uchiyama, Toru Ikegami, Norifumi Harimoto, Shinji Itoh, Yuji Soejima, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara

Cancer medicine 2017.7

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DOI： 10.1002/cam4.1087
SLC2A1/GLUT1 expression in mural nodules of intraductal papillary mucinous neoplasm of the pancreas.

Yasunori Oda, Shinichi Aishima, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Tetsuyuki Miyazaki, Masao Tanaka, Yoshinao Oda

Human pathology 2017.7

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DOI： 10.1016/j.humpath.2017.03.008
Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma.

Yoshiki Asayama, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Nobuhiro Fujita, Takao Ohtsuka, Tomoharu Yoshizumi, Shinichi Aishima, Yoshinao Oda, Hiroshi Honda

European radiology 2017.6

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DOI： 10.1007/s00330-016-4621-y
Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma.

Huanlin Wang, Kenichi Kohashi, Tomoharu Yoshizumi, Yukihiko Okumura, Yuki Tanaka, Masahiro Shimokawa, Takeshi Iwasaki, Shinichi Aishima, Yoshihiko Maehara, Yoshinao Oda

Human pathology 2017.6

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DOI： 10.1016/j.humpath.2017.03.007
Pathology of intrahepatic cholangiocarcinoma: Peripheral and perihilar type

Shinichi Aishima

Pathology of the Bile Duct 2017.5

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DOI： 10.1007/978-981-10-3500-5_12
Hepatobiliary and Pancreatic: Hepatocellular carcinoma developed with angiomyolipoma

T. Miyata, Y. Yamashita, T. Yamao, N. Umezaki, M. Tsukamoto, Y. Kitano, K. Yamamura, K. Arima, T. Kaida, S. Nakagawa, K. Imai, D. Hashimoto, A. Chikamoto, T. Ishiko, T. Asato, Y. Mikami, S. Aishima, H. Baba

Journal of Gastroenterology and Hepatology (Australia) 2017.3

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DOI： 10.1111/jgh.13655
Mass-forming intrahepatic cholangiocarcinoma: Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings.

Nobuhiro Fujita, Yoshiki Asayama, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Koichiro Moirta, Ken Shirabe, Shinichi Aishima, Huanlin Wang, Yoshinao Oda, Hiroshi Honda

European radiology 2017.2

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DOI： 10.1007/s00330-016-4386-3
Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma.

Keita Kai, Hiroki Koga, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro

World journal of gastroenterology 2017.2

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DOI： 10.3748/wjg.v23.i8.1397
Inverse correlation between CD8+ inflammatory cells and E-cadherin expression in gallbladder cancer: Tissue microarray and imaging analysis.

Keita Kai, Masanori Masuda, Shinichi Aishima

World journal of clinical cases 2017.1

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DOI： 10.12998/wjcc.v5.i1.1
Extrahepatic cholangiocarcinoma and pancreatic duct adenocarcinoma

Shinichi Aishima

Biliary Diseases with Pancreatic Counterparts: A New Disease Concept 2017.1

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Fatty change in moderately and poorly differentiated hepatocellular carcinoma on MRI: a possible mechanism related to decreased arterial flow

Y. Asayama, A. Nishie, K. Ishigami, Y. Ushijima, Y. Takayama, D. Okamoto, N. Fujita, Y. Kubo, S. Aishima, T. Yoshizumi, H. Honda

Clinical Radiology 2016.12

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DOI： 10.1016/j.crad.2016.04.020
Clinical Significances of Preoperative Classification of Intrahepatic Cholangiocarcinoma: Different Characteristics of Perihilar vs. Peripheral ICC.

Yo-Ichi Yamashita, Huanlin Wang, Takeshi Kurihara, Eiji Tsujita, Akihiro Nishie, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Shinichi Aishima, Hideo Baba

Anticancer research 2016.12

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DOI： 10.21873/anticanres.11260
特集転移性肝腫瘍のいま-なぜ･どこが原発臓器ごとに違うのか総論転移性肝腫瘍の病理

相島慎一, 山地康大郎

臨床外科 2016.11

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DOI： 10.11477/mf.1407211409
Malignant transformation of hepatocellular adenoma with bone marrow metaplasia arising in glycogen storage disease type I: A case report.

Tomohiro Iguchi, Motoyuki Yamagata, Takashi Sonoda, Kimihiko Yanagita, Tetsuhiro Fukahori, Eiji Tsujita, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara

Molecular and clinical oncology 2016.11

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Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1α and malignant potential in pancreatic neuroendocrine tumors.

2016.11

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The present study aimed to investigate the prognostic usefulness of the expression of glucose transporter type 1 (GLUT-1) and GLUT-2, hypoxia-inducible factor 1α (HIF-1α) and insulin-like growth factor II messenger RNA-binding protein 3 (IMP3) in pancreatic neuroendocrine tumors (pNETs). Immunohistochemical staining for GLUT-1, GLUT-2, HIF-1α and IMP3 was performed in 70 pNET specimens. The expression of GLUT-1 and HIF-1α was significantly higher in the World Health Organization grade 2 (G2), neuroendocrine carcinoma cases and mixed-type pNETs compared with the G1 cases. Vessel invasion, a high Ki-67 labeling index and a high mitotic count were significantly more frequent in the GLUT-1- and HIF-1α-positive cases compared with the negative cases. Lymph node metastasis was significantly higher in the GLUT-1-positive cases than in the negative cases. Insulin expression was significantly higher in the IMP3-positive cases than the negative cases. The GLUT-1 expression group experienced a significantly poor disease-free survival rate compared with the negative GLUT-1 expression group. HIF-1α expression was significantly correlated with poor disease-free survival and overall survival rates. A multivariate analysis revealed that lymph node metastasis was an independent risk factor for disease-free survival in all cases. In the G1/G2 group, tumor size and lymph node metastasis were independent risk factors for disease-free survival. Overall, the results suggested that GLUT-1 is a useful prognostic biomarker for pNETs.

DOI： 10.3892/ol.2016.5092
短期間に増大傾向を認めた肝腫瘍の1例—第93回北九州肝腫瘍研究会

空閑啓高, 永松伊織, 森松克哉, 田邊麗子, 豊福篤志, 轟木秀一, 廣吉元正, 堤宣翁, 大江真理, 佐藤丈顕, 天ヶ瀬洋正, 相島慎一

臨牀と研究 = The Japanese journal of clinical and experimental medicine 2016.8

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Effect of EGFR and p-AKT Overexpression on Chromosomal Instability in Gastric Cancer.

Yuichi Hisamatsu, Eiji Oki, Hajime Otsu, Koji Ando, Hiroshi Saeki, Eriko Tokunaga, Shinichi Aishima, Masaru Morita, Yoshinao Oda, Yoshihiko Maehara

Annals of surgical oncology 2016.6

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DOI： 10.1245/s10434-016-5097-3
Spalt-like transcription factor 4 immunopositivity is associated with epithelial cell adhesion molecule expression in combined hepatocellular carcinoma and cholangiocarcinoma.

Yuki Tanaka, Shinichi Aishima, Kenichi Kohashi, Yukihiko Okumura, Huanlin Wang, Tomoyuki Hida, Kazuhiro Kotoh, Ken Shirabe, Yoshihiko Maehara, Ryoichi Takayanagi, Yoshinao Oda

Histopathology 2016.4

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DOI： 10.1111/his.12806
Cytokeratin immunohistochemistry improves interobserver variability between unskilled pathologists in the evaluation of tumor budding in T1 colorectal cancer.

Keita Kai, Shinichi Aishima, Shigehisa Aoki, Yukari Takase, Kazuyoshi Uchihashi, Masanori Masuda, Aki Nishijima-Matsunobu, Mihoko Yamamoto, Kousuke Ide, Atsushi Nakayama, Makiko Yamasaki, Shuji Toda

Pathology international 2016.2

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DOI： 10.1111/pin.12374
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.

2016.1

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Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double deficiency in mouse liver (LMob1DKO) results in hyperplasia of oval cells and immature cholangiocytes accompanied by inflammatory cell infiltration and fibrosis. More than half of mutant mice die within 3 wk of birth. All survivors eventually develop liver cancers, particularly combined hepatocellular and cholangiocarcinomas (cHC-CCs) and intrahepatic cholangiocellular carcinomas (ICCs), and die by age 60 wk. Because this phenotype is the most severe among mutant mice lacking a Hippo signaling component, MOB1A/1B constitute the critical hub of Hippo signaling in mammalian liver. LMob1DKO liver cells show hyperproliferation, increased cell saturation density, hepatocyte dedifferentiation, enhanced epithelial-mesenchymal transition and cell migration, and elevated transforming growth factor beta(TGF-β)2/3 production. These changes are strongly dependent on Yes-Associated Protein-1 (Yap1) and partially dependent on PDZ-binding motif (Taz) and Tgfbr2, but independent of connective tissue growth factor (Ctgf). In human liver cancers, YAP1 activation is frequent in cHC-CCs and ICCs and correlates with SMAD family member 2 activation. Drug screening revealed that antiparasitic macrocyclic lactones inhibit YAP1 activation in vitro and in vivo. Targeting YAP1/TAZ with these drugs in combination with inhibition of the TGF-β pathway may be effective treatment for cHC-CCs and ICCs.

DOI： 10.1073/pnas.1517188113
Predictors and Diagnostic Strategies for Early-Stage Pancreatic Ductal Adenocarcinoma: A Retrospective Study.

Hideyo Kimura, Takao Ohtsuka, Taketo Matsunaga, Yusuke Watanabe, Koji Tamura, Noboru Ideno, Teppei Aso, Tetsuyuki Miyazaki, Takashi Osoegawa, Shinichi Aishima, Yoshihiro Miyasaka, Junji Ueda, Yasuhiro Ushijima, Hisato Igarashi, Tetsuhide Ito, Shunichi Takahata, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

Pancreas 2015.10

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DOI： 10.1097/MPA.0000000000000393
Predictors of Microvascular Invasion in Hepatocellular Carcinoma.

Yo-Ichi Yamashita, Ken Shirabe, Shinichi Aishima, Yoshihiko Maehara

Digestive diseases (Basel, Switzerland) 2015.9

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DOI： 10.1159/000438475
Impact of GATA-3 and FOXA1 expression in patients with hormone receptor-positive/HER2-negative breast cancer.

Yuichi Hisamatsu, Eriko Tokunaga, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Yuichiro Nakashima, Kenji Taketani, Shinichi Aishima, Yoshinao Oda, Masaru Morita, Yoshihiko Maehara

Breast cancer (Tokyo, Japan) 2015.9

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DOI： 10.1007/s12282-013-0515-x
Granulomatous reaction in hepatic inflammatory angiomyolipoma after chemoembolization and spontaneous rupture.

Keita Kai, Atsushi Miyosh, Shinichi Aishima, Kota Wakiyama, Shunya Nakashita, Shinji Iwane, Shinya Azama, Hiroyuki Irie, Hirokazu Noshiro

World journal of gastroenterology 2015.8

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DOI： 10.3748/wjg.v21.i32.9675
Surgical Outcomes of Hepatic Resection for Hepatitis B Virus Surface Antigen-Negative and Hepatitis C Virus Antibody-Negative Hepatocellular Carcinoma.

Yo-Ichi Yamashita, Daisuke Imai, Yuki Bekki, Koichi Kimura, Yoshiriro Matsumoto, Hidekazu Nakagawara, Toru Ikegami, Tomoharu Yoshizumi, Ken Shirabe, Shinichi Aishima, Yoshihiko Maehara

Annals of surgical oncology 2015.7

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DOI： 10.1245/s10434-014-4261-x
座談会 Round Table Discussion 肝細胞癌の病理学的多様性

坂元亨宇, 相島慎一, 中島収

The liver cancer journal = ザリバーキャンサージャーナル : 季刊学術雑誌 / 「The liver cancer journal」編集委員会編 2015.6

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桂枝加竜骨牡蛎湯，辛夷清肺湯による薬物性肝障害の1例

道免和文, 田中博文, 春野政虎, 下田慎治, 相島慎一

日本消化器病学会雑誌 2015.6

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症例は35歳時に桂枝加竜骨牡蛎湯による肝障害歴のある43歳の女性．副鼻腔炎に対し処方された辛夷清肺湯の内服後に総ビリルビン，AST，ALTの上昇がみられ，当科に紹介入院となった．辛夷清肺湯の薬物性肝障害と診断し，薬剤の中止で肝機能は正常化した．肝組織像もリンパ球・好酸球浸潤，巣状壊死の所見を認め，薬物性肝障害に合致した．桂枝加竜骨牡蛎湯，辛夷清肺湯による薬物性肝障害の報告はなく，貴重な症例と考えられた．

DOI： 10.11405/nisshoshi.112.1054
New Pathologic Stratification of Microvascular Invasion in Hepatocellular Carcinoma: Predicting Prognosis After Living-donor Liver Transplantation.

Tomohiro Iguchi, Ken Shirabe, Shinichi Aishima, Huanlin Wang, Nobuhiro Fujita, Mizuki Ninomiya, Yo-ichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Tomoharu Yoshizumi, Yoshinao Oda, Yoshihiko Maehara

Transplantation 2015.6

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DOI： 10.1097/TP.0000000000000489
Reply to Letter to the Editor by Pujals et al.

2015.6

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DOI： 10.1111/pin.12307
Recurrence 11 years after complete response to gemcitabine, 5-Fluorouracil, and Cisplatin chemotherapy followed by radiotherapy in a patient with advanced pancreatic cancer: a case report.

Tomoyuki Uchihara, Yo-Ichi Yamashita, Wang Hualin, Kazuki Takeishi, Shinji Itoh, Norihumi Harimoto, Tomoharu Yoshizumi, Shinichi Aishima, Ken Shirabe, Hideo Baba, Yoshihiko Maehara

Anticancer research 2015.5

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Long-term outcome of living-donor liver transplantation for combined hepatocellular-cholangiocarcinoma.

Shinji Itoh, Toru Ikegami, Tomoharu Yoshizumi, Huanlin Wang, Kazuki Takeishi, Norifumi Harimoto, Yo-Ichi Yamashita, Hirofumi Kawanaka, Shinichi Aishima, Ken Shirabe, Yoshihiko Maehara

Anticancer research 2015.4

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Correlation of HER2 expression with clinicopathological characteristics and prognosis in resectable gastric cancer.

Hajime Otsu, Eiji Oki, Ayae Ikawa-Yoshida, Hiroyuki Kawano, Koji Ando, Satoshi Ida, Yasue Kimura, Shinichi Aishima, Hiroshi Saeki, Masaru Morita, Shunji Kohnoe, Yoshinao Oda, Yoshihiko Maehara

Anticancer research 2015.4

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Evaluation of techniques to prevent colorectal anastomotic leakage.

Tetsuo Ikeda, Ryuichi Kumashiro, Eiji Oki, Kenji Taketani, Koji Ando, Shinichi Aishima, Tomohiko Akahoshi, Masaru Morita, Yoshihiko Maehara

The Journal of surgical research 2015.4

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DOI： 10.1016/j.jss.2014.11.045
Granulomatous interstitial pneumonia induced by the intake of rice bran pickles: a rare subtype of pulmonary manifestation associated with food allergy.

Yoshiaki Kinoshita, Atsuhiko Sakamoto, Shinichi Aishima, Kouko Hidaka

BMJ case reports 2015.4

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DOI： 10.1136/bcr-2014-208261
Hepatology: Rare Stevens-Johnson syndrome and vanishing bile duct syndrome induced by acetaminophen, requiring liver transplantation

N. Harimoto, H. Wang, T. Ikegami, K. Takeishi, S. Itoh, Y. I. Yamashita, T. Yoshizumi, S. Aishima, K. Shirabe, Y. Oda, Y. Maehara

Journal of Gastroenterology and Hepatology (Australia) 2015.4

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DOI： 10.1111/jgh.12849
[α-Fetoprotein-producing tumor].

2015.3

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Clinical significance of GNAS mutation in intraductal papillary mucinous neoplasm of the pancreas with concomitant pancreatic ductal adenocarcinoma.

Noboru Ideno, Takao Ohtsuka, Taketo Matsunaga, Hideyo Kimura, Yusuke Watanabe, Koji Tamura, Teppei Aso, Shinichi Aishima, Yoshihiro Miyasaka, Kenoki Ohuchida, Junji Ueda, Shunichi Takahata, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

Pancreas 2015.3

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DOI： 10.1097/MPA.0000000000000258
Primary hepatic tumors with myxoid change: morphologically unique hepatic adenomas and hepatocellular carcinomas.

Safia N Salaria, Rondell P Graham, Shinichi Aishima, Taofic Mounajjed, Matthew M Yeh, Michael S Torbenson

The American journal of surgical pathology 2015.3

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DOI： 10.1097/PAS.0000000000000382
Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type.

Shinichi Aishima, Yoshinao Oda

Journal of hepato-biliary-pancreatic sciences 2015.2

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DOI： 10.1002/jhbp.154
Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition.

Yusuke Mizuuchi, Shinichi Aishima, Kenoki Ohuchida, Koji Shindo, Minoru Fujino, Masami Hattori, Tetsuyuki Miyazaki, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

Laboratory investigation; a journal of technical methods and pathology 2015.2

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DOI： 10.1038/labinvest.2014.138
Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy.

Yuichiroh Umemoto, Shinji Okano, Yoshihiro Matsumoto, Hidekazu Nakagawara, Rumi Matono, Shohei Yoshiya, Yo-Ichi Yamashita, Tomoharu Yoshizumi, Toru Ikegami, Yuji Soejima, Mamoru Harada, Shinichi Aishima, Yoshinao Oda, Ken Shirabe, Yoshihiko Maehara

Journal of gastroenterology 2015.1

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DOI： 10.1007/s00535-014-0933-3
A novel serum marker, glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA(+)-M2BP), for assessing liver fibrosis.

Takeo Toshima, Ken Shirabe, Toru Ikegami, Tomoharu Yoshizumi, Atsushi Kuno, Akira Togayachi, Masanori Gotoh, Hisashi Narimatsu, Masaaki Korenaga, Masashi Mizokami, Akihito Nishie, Shinichi Aishima, Yoshihiko Maehara

Journal of gastroenterology 2015.1

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DOI： 10.1007/s00535-014-0946-y
Hepatocellular carcinoma: clinical significance of signal heterogeneity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging.

Nobuhiro Fujita, Akihiro Nishie, Yuichiro Kubo, Yoshiki Asayama, Yasuhiro Ushijima, Yukihisa Takayama, Koichiro Moirta, Ken Shirabe, Shinichi Aishima, Hiroshi Honda

European radiology 2015.1

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DOI： 10.1007/s00330-014-3349-9
Micro RNA-373 is down-regulated in pancreatic cancer and inhibits cancer cell invasion.

Kohei Nakata, Kenoki Ohuchida, Kazuhiro Mizumoto, Shinichi Aishima, Yoshinao Oda, Eishi Nagai, Masao Tanaka

Annals of surgical oncology 2014.12

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DOI： 10.1245/s10434-014-3676-8
Different histological sequelae of immune-mediated graft dysfunction after interferon treatment in transplanted dual grafts from living donors.

Mizuki Ninomiya, Shinichi Aishima, Tomoharu Yoshizumi, Toru Ikegami, Huanlin Wang, Norifumi Harimoto, Shinji Ito, Hideaki Uchiyama, Yuji Soejima, Hirofumi Kawanaka, Ken Shirabe, Yoshihiko Maehara

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2014.12

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DOI： 10.1002/lt.23996
Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: pathogenesis and histological characteristics.

Shinichi Aishima, Yuki Tanaka, Yuichiro Kubo, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

Pathology international 2014.11

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DOI： 10.1111/pin.12209
"High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas.

Teppei Aso, Takao Ohtsuka, Taketo Matsunaga, Hideyo Kimura, Yusuke Watanabe, Koji Tamura, Noboru Ideno, Takashi Osoegawa, Shunnichi Takahata, Koji Shindo, Yasuhiro Ushijima, Shinichi Aishima, Yoshinao Oda, Tetsuhide Ito, Kazuhiro Mizumoto, Masao Tanaka

Pancreas 2014.11

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DOI： 10.1097/MPA.0000000000000199
The apelin-APJ system induces tumor arteriogenesis in hepatocellular carcinoma.

Jun Muto, Ken Shirabe, Tomoharu Yoshizumi, Toru Ikegami, Shinichi Aishima, Kousei Ishigami, Yoshikazu Yonemitsu, Tetsuo Ikeda, Yuji Soejima, Yoshihiko Maehara

Anticancer research 2014.10

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Gallbladder cancer: Clinical and pathological approach.

Keita Kai, Shinichi Aishima, Kohji Miyazaki

World journal of clinical cases 2014.10

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DOI： 10.12998/wjcc.v2.i10.515
Pathological manifestation of difference in washout pattern of adrenal hyperplasia on dynamic CT.

Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, Yasuhiro Ushijima, Yukihisa Takayama, Akira Yokomizo, Katsunori Tatsugami, Junichi Inokuchi, Nobuhiro Fujita, Yuichiro Kubo, Shinichi Aishima, Masakazu Hirakawa, Hiroshi Honda

Journal of medical imaging and radiation oncology 2014.10

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DOI： 10.1111/1754-9485.12211
Podoplanin expression in the cyst wall correlates with the progression of intraductal papillary mucinous neoplasm.

Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Takao Ohtsuka, Shoji Tokunaga, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

Virchows Archiv : an international journal of pathology 2014.9

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DOI： 10.1007/s00428-014-1610-x
Pancreatic intraepithelial neoplasia in the background of invasive ductal carcinoma of the pancreas as a prognostic factor.

Yasunori Oda, Shinichi Aishima, Katsuya Morimatsu, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Tetsuyuki Miyazaki, Masao Tanaka, Yoshinao Oda

Histopathology 2014.9

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DOI： 10.1111/his.12397
Correlation between biological marker expression and fluorine-18 fluorodeoxyglucose uptake in hepatocellular carcinoma.

Yohei Mano, Shinichi Aishima, Yuichiro Kubo, Yuki Tanaka, Takashi Motomura, Takeo Toshima, Ken Shirabe, Shingo Baba, Yoshihiko Maehara, Yoshinao Oda

American journal of clinical pathology 2014.9

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DOI： 10.1309/AJCPG8AFJ5NRKLLM
Significance of accurate human epidermal growth factor receptor-2 (HER2) evaluation as a new biomarker in gastric cancer.

Yasue Kimura, Eiji Oki, Ayae Yoshida, Shinichi Aishima, Yoko Zaitsu, Hajime Ohtsu, Koji Ando, Satoshi Ida, Hiroshi Saeki, Masaru Morita, Tetsuya Kusumoto, Yoshinao Oda, Yoshihiko Maehara

Anticancer research 2014.8

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Different expression of glucose transporters in the progression of intrahepatic cholangiocarcinoma.

Yuichiro Kubo, Shinichi Aishima, Yuki Tanaka, Koji Shindo, Yusuke Mizuuchi, Koichiro Abe, Ken Shirabe, Yoshihiko Maehara, Hiroshi Honda, Yoshinao Oda

Human pathology 2014.8

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DOI： 10.1016/j.humpath.2014.03.008
Phase II study of docetaxel and S-1 (DS) as neoadjuvant chemotherapy for clinical stage III resectable gastric cancer.

Eiji Oki, Yasunori Emi, Tetsuya Kusumoto, Yoshihisa Sakaguchi, Manabu Yamamoto, Noriaki Sadanaga, Mototsugu Shimokawa, Takeharu Yamanaka, Hiroshi Saeki, Masaru Morita, Ikuo Takahashi, Naoki Hirabayashi, Kenji Sakai, Hiroyuki Orita, Shinichi Aishima, Yoshihiro Kakeji, Kazuya Yamaguchi, Kazuhiro Yoshida, Hideo Baba, Yoshihiko Maehara

Annals of surgical oncology 2014.7

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DOI： 10.1245/s10434-014-3594-9
Histological features of precancerous and early cancerous lesions of biliary tract carcinoma.

Shinichi Aishima, Yuichiro Kubo, Yuki Tanaka, Yoshinao Oda

Journal of hepato-biliary-pancreatic sciences 2014.7

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DOI： 10.1002/jhbp.71
New scoring system for prediction of microvascular invasion in patients with hepatocellular carcinoma.

Ken Shirabe, Takeo Toshima, Koichi Kimura, Yoichi Yamashita, Tetsuo Ikeda, Toru Ikegami, Tomoharu Yoshizumi, Koichiro Abe, Shinichi Aishima, Yoshihiko Maehara

Liver international : official journal of the International Association for the Study of the Liver 2014.7

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DOI： 10.1111/liv.12459
Peritoneal myofibroblasts at metastatic foci promote dissemination of pancreatic cancer.

Shin Akagawa, Kenoki Ohuchida, Nobuhiro Torata, Masami Hattori, Daiki Eguchi, Kenji Fujiwara, Shingo Kozono, Lin Cui, Naoki Ikenaga, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto, Yoshinao Oda, Masao Tanaka

International journal of oncology 2014.7

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DOI： 10.3892/ijo.2014.2391
Role of tumor-associated macrophages in the angiogenesis of well-differentiated hepatocellular carcinoma: pathological-radiological correlation.

Nobuhiro Fujita, Akihiro Nishie, Shinichi Aishima, Yuichiro Kubo, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Yasuhiro Ushijima, Yukihisa Takayama, Ken Shirabe, Yoshinao Oda, Hiroshi Honda

Oncology reports 2014.6

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DOI： 10.3892/or.2014.3138
Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma.

Mikako Osada, Shinichi Aishima, Minako Hirahashi, Nobuyoshi Takizawa, Shunsuke Takahashi, Kazuhiko Nakamura, Masao Tanaka, Yoshihiko Maehara, Ryoichi Takayanagi, Yoshinao Oda

Human pathology 2014.6

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DOI： 10.1016/j.humpath.2014.02.003
Analysis of risk factors for recurrence after curative resection of well-differentiated pancreatic neuroendocrine tumors based on the new grading classification.

Kosuke Tsutsumi, Takao Ohtsuka, Minoru Fujino, Hiroshi Nakashima, Shinichi Aishima, Junji Ueda, Shunichi Takahata, Masafumi Nakamura, Yoshinao Oda, Masao Tanaka

Journal of hepato-biliary-pancreatic sciences 2014.6

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Language：English

DOI： 10.1002/jhbp.47
Chronic immune-mediated reaction syndrome as the cause of late graft mortality in living-donor liver transplantation for primary biliary cirrhosis

N. Harimoto, T. Ikegami, H. Nakagawara, Y. I. Yamashita, T. Yoshizumi, H. Uchiyama, Y. Soejima, T. Ikeda, K. Shirabe, S. Aishima, Y. Oda, Y. Maehara

Transplantation Proceedings 2014.6

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DOI： 10.1016/j.transproceed.2014.02.021
Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer.

Eriko Tokunaga, Yuichiro Nakashima, Nami Yamashita, Yuichi Hisamatsu, Satoko Okada, Sayuri Akiyoshi, Shinichi Aishima, Hiroyuki Kitao, Masaru Morita, Yoshihiko Maehara

Breast cancer (Tokyo, Japan) 2014.5

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DOI： 10.1007/s12282-012-0398-2
Strategies to treat interferon-induced graft dysfunction after living donor liver transplantation for hepatitis C.

Toru Ikegami, Huanlin Wang, Tomoharu Yoshizumi, Takeo Toshima, Shinichi Aishima, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Shinji Shimoda, Ken Shirabe, Yoshihiko Maehara

Hepatology international 2014.4

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DOI： 10.1007/s12072-013-9496-2
Elevated expression level of microRNA-196a is predictive of intestinal-type intraductal papillary mucinous neoplasm of the pancreas.

Teppei Aso, Takao Ohtsuka, Koji Tamura, Noboru Ideno, Hiroshi Kono, Yosuke Nagayoshi, Kennoki Ohuchida, Junji Ueda, Shunnichi Takahata, Koji Shindo, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

Pancreas 2014.4

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DOI： 10.1097/MPA.0000000000000042
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.

Minako Hirahashi, Yutaka Koga, Reiko Kumagai, Shinichi Aishima, Kenichi Taguchi, Yoshinao Oda

Pathology international 2014.4

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DOI： 10.1111/pin.12152
A case of invasive micropapillary carcinoma of the breast involving extensive lymph node metastasis.

Kenji Taketani, Eriko Tokunaga, Nami Yamashita, Kimihiro Tanaka, Yoko Zaitsu, Sayuri Akiyoshi, Satoko Okada, Shinichi Aishima, Masaru Morita, Yoshihiko Maehara

World journal of surgical oncology 2014.4

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DOI： 10.1186/1477-7819-12-84
PS-155-1 当院における胆管内乳頭状腫瘍(IPNB)切除例の検討(PS-155 肝胆道腫瘍・その他,ポスターセッション,第114回日本外科学会定期学術集会)

梶山潔, 皆川亮介, 丸山晴司, 井口詔一, 廣瀬皓介, 赤峰翔, 影山優美子, 平山佳愛, 高橋良影, 武谷憲二, 中ノ子智徳, 吉田倫太郎, 古賀聡, 甲斐正徳, 増本陽秀, 福谷龍郎, 大屋正文, 相島慎一

日本外科学会雑誌 2014.3

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OP-005-2 肝癌に対する生体肝移植後の肝癌再発の新たな予後因子 : 侵襲の程度に基づく組織学的高度脈管侵襲分類の有用性(OP-005 肝移植-2,一般演題,第114回日本外科学会定期学術集会)

井口友宏, 調憲, 池上徹, 吉住朋晴, 別城悠樹, 王歓林, 今井大祐, 松本佳大, 木村光一, 中川原英和, 吉屋匠平, 二宮瑞樹, 山下洋市, 内山秀昭, 副島雄二, 川中博文, 池田哲夫, 相島慎一, 小田義直, 前原喜彦

日本外科学会雑誌 2014.3

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PLS-10-3 主膵管型IPMNのmonoclonalityとGNAS遺伝子変異の意義(PLS-10 プレナリーセッション(10)「膵臓」,第114回日本外科学会定期学術集会)

田村公二, 大塚隆生, 松永壮人, 木村英世, 渡邉雄介, 井手野昇, 安蘓鉄平, 宮崎哲之, 相島慎一, 大内田研宙, 上田純二, 高畑俊一, 小田義直, 水元一博, 田中雅夫

日本外科学会雑誌 2014.3

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Key endoscopic ultrasound features of pancreatic ductal adenocarcinoma smaller than 20 mm.

Akira Aso, Eikichi Ihara, Takashi Osoegawa, Kazuhiko Nakamura, Soichi Itaba, Hisato Igarashi, Tetsuhide Ito, Shinichi Aishima, Yoshinao Oda, Masao Tanaka, Ryoichi Takayanagi

Scandinavian journal of gastroenterology 2014.3

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DOI： 10.3109/00365521.2013.878745
Treatment strategy for main duct intraductal papillary mucinous neoplasms of the pancreas based on the assessment of recurrence in the remnant pancreas after resection: a retrospective review.

Koji Tamura, Takao Ohtsuka, Noboru Ideno, Teppei Aso, Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Shunichi Takahata, Yasuhiro Ushijima, Tetsuhide Ito, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

Annals of surgery 2014.2

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DOI： 10.1097/SLA.0b013e3182a690ff
Follicular pancreatitis, report of a case clinically mimicking pancreatic cancer and literature review.

Yusuke Mizuuchi, Shinichi Aishima, Masami Hattori, Yasuhiro Ushijima, Akira Aso, Shunichi Takahata, Takao Ohtsuka, Junji Ueda, Masao Tanaka, Yoshinao Oda

Pathology, research and practice 2014.2

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DOI： 10.1016/j.prp.2013.09.005
特集見直される膵癌診療の新展開診断における新展開膵液細胞診および膵液遺伝子検査による膵癌診断

安蘓鉄平, 大塚隆生, 木村英世, 松永壮人, 渡邉雄介, 田村公二, 井手野昇, 大内田研宙, 上田純二, 高畑俊一, 相島慎一, 五十嵐久人, 伊藤鉄英, 小田義直, 水元一博, 田中雅夫

臨床外科 2014.1

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DOI： 10.11477/mf.1407104900
Tissue tablet method: an efficient tissue banking procedure applicable to both molecular analysis and frozen tissue microarray.

Nobuhiro Torata, Kenoki Ohuchida, Shin Akagawa, Lin Cui, Shingo Kozono, Kazuhiro Mizumoto, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

Human pathology 2014.1

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DOI： 10.1016/j.humpath.2013.08.013
Expression of glucagon-like Peptide 1 receptor and its effects on biologic behavior in pancreatic neuroendocrine tumors.

Ana Ines Cases, Takao Ohtsuka, Minoru Fujino, Noboru Ideno, Shingo Kozono, Ming Zhao, Kenoki Ohuchida, Shinichi Aishima, Masatoshi Nomura, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka

Pancreas 2014.1

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DOI： 10.1097/MPA.0b013e3182a71537
Intraoperative irrigation cytology of the remnant pancreas to detect remnant distinct pancreatic ductal adenocarcinoma in patients with intraductal papillary mucinous neoplasm undergoing partial pancreatectomy.

Yasuhisa Mori, Takao Ohtsuka, Koji Tamura, Noboru Ideno, Teppei Aso, Hiroshi Kono, Yosuke Nagayoshi, Junji Ueda, Shunichi Takahata, Shinichi Aishima, Fumihiko Ookubo, Yoshinao Oda, Masao Tanaka

Surgery 2014.1

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DOI： 10.1016/j.surg.2013.06.059
Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia.

Yasunori Sato, Motoko Sasaki, Kenichi Harada, Shinichi Aishima, Toshio Fukusato, Hidenori Ojima, Yae Kanai, Masayoshi Kage, Yasuni Nakanuma, Hirohito Tsubouchi

Journal of gastroenterology 2014.1

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DOI： 10.1007/s00535-013-0810-5
Spontaneous massive necrosis of hepatocellular carcinoma with narrowing and occlusion of the arteries and portal veins.

Takahiro Tomino, Yo-Ichi Yamashita, Tomohiro Iguchi, Shinji Itoh, Mizuki Ninomiya, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Hirofumi Kawanaka, Tetsuo Ikeda, Shinichi Aishima, Ken Shirabe, Yoshihiko Maehara

Case reports in gastroenterology 2014.1

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DOI： 10.1159/000362440
mFOLFOX6療法後に発症した門脈圧亢進症の1例

緒方大聡, 具嶋敏文, 丸岡新子, 高崎智子, 田中吏佐, 松浦隆志, 相島慎一, 高橋和弘

日本消化器病学会雑誌 2013.12

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症例は46歳男性．S状結腸癌肝転移の診断でS状結腸切除術，肝部分切除術，胆嚢切除術を施行された．術後化学療法としてmFOLFOX6療法を施行された頃から血小板減少と脾腫が出現し，3年後にF3の食道胃静脈瘤を認めた．肝生検組織では，大腸癌手術時の摘出肝と比して類洞の拡張に加え門脈が狭小化して不明瞭となっていた．Oxaliplatinは非肝硬変性の門脈圧亢進症をきたすことがあり，留意すべきである．

DOI： 10.11405/nisshoshi.110.2119, 10.2957/kanzo.61.358_references_DOI_UKRW5UlBD1NDFXslFg78J5YToE0, 10.5833/jjgs.2017.0194_references_DOI_UKRW5UlBD1NDFXslFg78J5YToE0
Differential impact of the expression of the androgen receptor by age in estrogen receptor-positive breast cancer.

Eriko Tokunaga, Yuichi Hisamatsu, Kenji Taketani, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Kimihiro Tanaka, Hiroshi Saeki, Eiji Oki, Shinichi Aishima, Yoshinao Oda, Masaru Morita, Yoshihiko Maehara

Cancer medicine 2013.12

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DOI： 10.1002/cam4.138
Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas.

Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Kenji Fujiwara, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda

Molecular cancer 2013.12

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DOI： 10.1186/1476-4598-12-168
Migratory activity of CD105+ pancreatic cancer cells is strongly enhanced by pancreatic stellate cells.

Kenji Fujiwara, Kenoki Ohuchida, Takao Ohtsuka, Kazuhiro Mizumoto, Koji Shindo, Naoki Ikenaga, Lin Cui, Shunichi Takahata, Shinichi Aishima, Masao Tanaka

Pancreas 2013.11

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DOI： 10.1097/MPA.0b013e318293e7bd
Decreased roundabout 1 expression promotes development of intrahepatic cholangiocarcinoma.

Yohei Mano, Shinichi Aishima, Takasuke Fukuhara, Yuki Tanaka, Yuichiro Kubo, Takashi Motomura, Takeo Toshima, Tomohiro Iguchi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

Human pathology 2013.11

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DOI： 10.1016/j.humpath.2013.03.022
特集術前画像診断のポイントと術中解剖認識 IV.肝･胆･膵 IPMN

渡邉雄介, 大塚隆生, 田村公二, 木村英世, 松永壮人, 井手野昇, 安蘇鉄平, 上田純二, 高畑俊一, 牛島泰宏, 伊藤鉄英, 水内祐介, 相島慎一, 小田義直, 水元一博, 田中雅夫

臨床外科 2013.10

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DOI： 10.11477/mf.1407104812
A case of fatal intrahepatic cholestasis with primary AL amyloidosis: is early diagnosis possible?

Shinichiro Takao, Kosuke Tanaka, Masayuki Miyazaki, Masatake Tanaka, Tomoko Ohashi, Masaki Kato, Kazuhiro Kotoh, Shinichi Aishima, Ryoichi Takayanagi

Clinical journal of gastroenterology 2013.10

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DOI： 10.1007/s12328-013-0406-x
Insulin-like growth factor II messenger RNA-binding protein-3 is a valuable diagnostic and prognostic marker of intraductal papillary mucinous neoplasm.

Katsuya Morimatsu, Shinichi Aishima, Hidetaka Yamamoto, Akifumi Hayashi, Kohei Nakata, Yasunori Oda, Koji Shindo, Minoru Fujino, Masao Tanaka, Yoshinao Oda

Human pathology 2013.9

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DOI： 10.1016/j.humpath.2012.12.020
S-1/Docetaxel併用療法にて同時性肝転移が病理学的完全奏効となった胃癌の1例

北原大和, 沖英次, 佐伯浩司, 安藤幸滋, 調憲, 鴻江俊治, 相島慎一, 掛地吉弘, 前原喜彦

癌と化学療法 2013.8

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Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas.

Yasunori Oda, Shinichi Aishima, Katsuya Morimatsu, Akifumi Hayashi, Koji Shindo, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Masao Tanaka, Yoshinao Oda

Human pathology 2013.8

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DOI： 10.1016/j.humpath.2012.12.001
Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis.

Yohei Mano, Ken Shirabe, Yo-Ichi Yamashita, Norifumi Harimoto, Eiji Tsujita, Kazuki Takeishi, Shinichi Aishima, Toru Ikegami, Tomoharu Yoshizumi, Takeharu Yamanaka, Yoshihiko Maehara

Annals of surgery 2013.8

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DOI： 10.1097/SLA.0b013e318297ad6b
Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype.

Noboru Ideno, Takao Ohtsuka, Hiroshi Kono, Kenji Fujiwara, Yasunori Oda, Shinichi Aishima, Tetsuhide Ito, Kousei Ishigami, Shoji Tokunaga, Kenoki Ohuchida, Shunichi Takahata, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

Annals of surgery 2013.7

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DOI： 10.1097/SLA.0b013e31828cd008
Distinctive histopathologic findings of pancreatic hamartomas suggesting their "hamartomatous" nature: a study of 9 cases.

Hiroshi Yamaguchi, Shinichi Aishima, Yoshinao Oda, Hiroki Mizukami, Takuma Tajiri, Sohsuke Yamada, Takashi Tasaki, Keisuke Yamakita, Koji Imai, Fumi Kawakami, Shigeo Hara, Keiji Hanada, Tomohiro Iiboshi, Toshikatsu Fukuda, Hiroshi Imai, Hiroyuki Inoue, Tatsuya Nagakawa, Shunji Muraoka, Toru Furukawa, Michio Shimizu

The American journal of surgical pathology 2013.7

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DOI： 10.1097/PAS.0b013e318283ce4c
High expression of microRNA-155 is associated with the aggressive malignant behavior of gallbladder carcinoma.

Hiroshi Kono, Masafumi Nakamura, Takao Ohtsuka, Yosuke Nagayoshi, Yasuhisa Mori, Shunichi Takahata, Shinichi Aishima, Masao Tanaka

Oncology reports 2013.7

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DOI： 10.3892/or.2013.2443
Early extensive viremia, but not rs8099917 genotype, is the only predictor for cholestatic hepatitis C after living-donor liver transplantation.

Toru Ikegami, Ken Shirabe, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Masaki Kato, Shinji Shimoda, Shinichi Aishima, Yuji Soejima, Tomoharu Yoshizumi, Yoshihiko Maehara

Hepatology research : the official journal of the Japan Society of Hepatology 2013.6

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DOI： 10.1111/hepr.12003
Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma.

Shinichi Aishima, Yohei Mano, Yuki Tanaka, Yuichiro Kubo, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

Human pathology 2013.6

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DOI： 10.1016/j.humpath.2012.09.004
Vimentin as a poor prognostic factor for triple-negative breast cancer.

Nami Yamashita, Eriko Tokunaga, Hiroyuki Kitao, Yuichi Hisamatsu, Kenji Taketani, Sayuri Akiyoshi, Satoko Okada, Shinichi Aishima, Masaru Morita, Yoshihiko Maehara

Journal of cancer research and clinical oncology 2013.5

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DOI： 10.1007/s00432-013-1376-6
Clinical usefulness of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography for patients with primary liver cancer with special reference to rare histological types, hepatocellular carcinoma with sarcomatous change and combined hepatocellular and cholangiocarcinoma.

Hideki Ijichi, Ken Shirabe, Akinobu Taketomi, Tomoharu Yoshizumi, Toru Ikegami, Youhei Mano, Shinichi Aishima, Koichiro Abe, Hiroshi Honda, Yoshihiko Maehara

Hepatology research : the official journal of the Japan Society of Hepatology 2013.5

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DOI： 10.1111/j.1872-034X.2012.01107.x
Kindlin-1 expression is involved in migration and invasion of pancreatic cancer.

Prawej Mahawithitwong, Kenoki Ohuchida, Naoki Ikenaga, Hayato Fujita, Ming Zhao, Shingo Kozono, Koji Shindo, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto, Masao Tanaka

International journal of oncology 2013.4

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DOI： 10.3892/ijo.2013.1838
Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case.

Mikihiro Kohno, Ken Shirabe, Yohei Mano, Jun Muto, Takashi Motomura, Kazuki Takeishi, Takeo Toshima, Masanori Yoshimatsu, Hideki Ijichi, Noboru Harada, Shinichi Aishima, Hideaki Uchiyama, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara

Surgery today 2013.4

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DOI： 10.1007/s00595-012-0202-0
YT-7-6(YRA) GNAS変異を有しない膵管内乳頭粘液性腫瘍は通常型膵癌を合併する頻度が高い(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会)

井手野昇, 大塚隆生, 小田康徳, 田村公二, 安蕪鉄平, 河野博, 永吉洋介, 相島慎一, 大内田研宙, 上田純二, 高畑俊一, 水元一博, 田中雅夫

日本外科学会雑誌 2013.3

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PD-2-1 根治切除可能な進行胃癌に対する術前Docetaxel/S-1併用補助化学療法の多施設共同臨床第II相試験(PD パネルディスカッション,第113回日本外科学会定期学術集会)

楠本哲也, 沖英次, 江見泰徳, 掛地吉弘, 坂口善久, 吉田和弘, 馬場秀夫, 相島慎一, 徳永章二, 前原喜彦

日本外科学会雑誌 2013.3

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PS-113-6 CD166陰性膵癌細胞は強い浸潤能・遊走能を有する(PS ポスターセッション,第113回日本外科学会定期学術集会)

藤原謙次, 大内田研宙, 進藤幸治, 赤川進, 江口大樹, 小薗真吾, 崔林, 大塚隆生, 高畑俊一, 相島慎一, 水元一博, 田中雅夫

日本外科学会雑誌 2013.3

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PS-225-1 主膵管型IPMNの治療戦略 : 残膵再発例から見た至適術式の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

田村公二, 大塚隆生, 進藤幸治, 井手野昇, 安蕪鉄平, 河野博, 永吉洋介, 大内田研宙, 相島慎一, 上田純二, 高畑俊一, 水元一博, 田中雅夫

日本外科学会雑誌 2013.3

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PS-226-6 腸型膵管内乳頭粘液性腫瘍(IPMN)におけるmicroRNA-196aの高発現(PS ポスターセッション,第113回日本外科学会定期学術集会)

安蘓鉄平, 大塚隆生, 田村公二, 井手野昇, 河野博, 永吉洋介, 進藤幸治, 大内田研宙, 相島慎一, 上田純二, 高畑俊一, 水元一博, 田中雅夫

日本外科学会雑誌 2013.3

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PS-341-3 生体肝移植術後における胆汁うっ滞性C型肝炎発症の規定因子の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

松本佳大, 調憲, 副島雄二, 吉住朋晴, 池上徹, 山下洋市, 相島慎一, 播本憲史, 戸島剛男, 吉屋匠平, 中川原英和, 川崎淳司, 木村光一, 前原喜彦

日本外科学会雑誌 2013.3

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PS-375-4 高品質かつ簡便な凍結組織アレイ作製法 : 手術切除組織を効率良く保存する保存組織タブレット法を活用して(PS ポスターセッション,第113回日本外科学会定期学術集会)

寅田信博, 赤川進, 崔林, 大内田研宙, 小園真吾, 水元一博, 相島慎一, 小田義直, 田中雅夫

日本外科学会雑誌 2013.3

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RSF-14-1 胃カルチノイド同時性肝転移の一切除例に関する検討(RSF 研修医の発表セッション,第113回日本外科学会定期学術集会)

佐々木駿, 井田智, 安藤幸滋, 木村和恵, 佐伯浩司, 沖英次, 森田勝, 楠本哲也, 池田哲夫, 相島慎一, 前原喜彦

日本外科学会雑誌 2013.3

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Role of endoscopic retrograde pancreatography for early detection of pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm of the pancreas.

Takao Ohtsuka, Noboru Ideno, Teppei Aso, Yosuke Nagayoshi, Hiroshi Kono, Yasuhisa Mori, Shunichi Takahata, Yasunori Oda, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

Journal of hepato-biliary-pancreatic sciences 2013.3

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DOI： 10.1007/s00534-012-0541-7
Ezrin expression and its phosphorylation in gastric carcinoma with lymphoid stroma and Epstein-Barr virus infection.

Taro Tobo, Minako Hirahashi, Takashi Yao, Shinichi Aishima, Yoshinao Oda

Molecular and clinical oncology 2013.3

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Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC.

Masatake Tanaka, Yuko Masaki, Kosuke Tanaka, Masayuki Miyazaki, Masaki Kato, Rie Sugimoto, Kazuhiko Nakamura, Shinichi Aishima, Ken Shirabe, Makoto Nakamuta, Munechika Enjoji, Kazuhiro Kotoh, Ryoichi Takayanagi

Molecular medicine reports 2013.2

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DOI： 10.3892/mmr.2012.1201
A morphological study of the removed livers from patients receiving living donor liver transplantation for adult biliary atresia.

Toshiharu Matsuura, Kenichi Kohashi, Yusuke Yanagi, Isamu Saeki, Makoto Hayashida, Shinichi Aishima, Yoshinao Oda, Tomoaki Taguchi

Pediatric surgery international 2012.12

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DOI： 10.1007/s00383-012-3183-6
Management strategy for multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas.

Yasuhisa Mori, Takao Ohtsuka, Hiroshi Kono, Noboru Ideno, Teppei Aso, Yosuke Nagayoshi, Shunichi Takahata, Masafumi Nakamura, Kousei Ishigami, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

Pancreas 2012.10

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DOI： 10.1097/MPA.0b013e31824b22c6
The risk of lymph node metastasis in mucosal gastric carcinoma: especially for a mixture of differentiated and undifferentiated adenocarcinoma.

Kohei Nakata, Eishi Nagai, Yoshihiro Miyasaka, Kenoki Ohuchida, Takao Ohtsuka, Hiroki Toma, Minako Hirahashi, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

Hepato-gastroenterology 2012.9

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DOI： 10.5754/hge10130
Diagnostic significance of a dilated orifice of the duodenal papilla in intraductal papillary mucinous neoplasm of the pancreas.

Teppei Aso, Takao Ohtsuka, Noboru Ideno, Hiroshi Kono, Yosuke Nagayoshi, Yasuhisa Mori, Kennoki Ohuchida, Junji Ueda, Shunnichi Takahata, Katsuya Morimatsu, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Kazuhiro Mizumoto, Masao Tanaka

Gastrointestinal endoscopy 2012.8

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DOI： 10.1016/j.gie.2012.03.682
Primary graft dysfunction after living donor liver transplantation is characterized by delayed functional hyperbilirubinemia

Toru Ikegami, K. Shirabe, T. Yoshizumi, S. Aishima, Y. A. Taketomi, Y. Soejima, H. Uchiyama, H. Kayashima, T. Toshima, Y. Maehara

American Journal of Transplantation 2012.7

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DOI： 10.1111/j.1600-6143.2012.04052.x
Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas.

Takao Ohtsuka, Hiroshi Kono, Reiko Tanabe, Yosuke Nagayoshi, Yasuhisa Mori, Yoshihiko Sadakari, Shunichi Takahata, Yasunori Oda, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

American journal of surgery 2012.7

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DOI： 10.1016/j.amjsurg.2011.04.007
Predictors for microinvasion of small hepatocellular carcinoma ≤ 2 cm.

2012.6

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BACKGROUND: Hepatocellular carcinoma (HCC) ≤ 2 cm in diameter is considered to have a low potential for malignancy. METHODS: A retrospective review was undertaken of 149 patients with primary solitary HCC ≤ 2 cm who underwent initial hepatic resection between 1994 and 2010. The independent predictors of the microinvasion (MI) such as portal venous, hepatic vein, or bile duct infiltration and/or intrahepatic metastasis were identified by multivariate analysis. Prognosis of patients with HCC ≤ 2 cm accompanied by MI was compared to that of patients with HCC ≤ 2 cm without MI. RESULTS: Forty-three patients with HCC ≤ 2 cm had MI in patients (28.9%). Three independent predictors of the MI were revealed: invasive gross type (simple nodular type with extranodular growth or confluent multinodular type), des-γ-carboxy prothrombin (DCP) >100 mAU/ml, and poorly differentiated. Disease-free survival rates of patients with HCC ≤ 2 cm with MI (3 year 44%) were significantly worse than those for HCC ≤ 2 cm without MI (3 year 72%). This disadvantage of disease-free survival rate of patients with HCC ≤ 2 cm with MI could be dissolved by hepatic resection with a wide tumor margin of ≥ 5 mm (P = 0.04). CONCLUSIONS: Even in cases of HCC ≤ 2 cm, patients who are suspected of having invasive gross type tumors in preoperative imaging diagnosis or who have a high DCP level (>100 mAU/ml) are at risk for MI. Therefore, in such patients, hepatic resection with a wide tumor margin should be recommended.

DOI： 10.1245/s10434-011-2195-0
Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production.

Kosuke Tsutsumi, Takao Ohtsuka, Yasuhisa Mori, Minoru Fujino, Takaharu Yasui, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Tetsuhide Ito, Masao Tanaka

Journal of gastroenterology 2012.6

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DOI： 10.1007/s00535-012-0540-0
Enhancement pattern analysis of hypervascular hepatocellular carcinoma on dynamic MR imaging with histopathological correlation: validity of portal phase imaging for predicting tumor grade.

Daisuke Okamoto, Kengo Yoshimitsu, Akihiro Nishie, Tsuyoshi Tajima, Yoshiki Asayama, Kousei Ishigami, Masakazu Hirakawa, Yasuhiro Ushijima, Daisuke Kakihara, Tomohiro Nakayama, Yunosuke Nishihara, Shinichi Aishima, Akinobu Taketomi, Junji Kishimoto, Hiroshi Honda

European journal of radiology 2012.6

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DOI： 10.1016/j.ejrad.2011.02.056
Impact of FOXA1 expression on the prognosis of patients with hormone receptor-positive breast cancer.

Yuichi Hisamatsu, Eriko Tokunaga, Nami Yamashita, Sayuri Akiyoshi, Satoko Okada, Yuichiro Nakashima, Shinichi Aishima, Masaru Morita, Yoshihiro Kakeji, Yoshihiko Maehara

Annals of surgical oncology 2012.4

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DOI： 10.1245/s10434-011-2094-4
SF-074-5 膵癌におけるCD271陽性膵星細胞の意義(SF-074 サージカルフォーラム(74)膵基礎-3(間質相互作用),第112回日本外科学会定期学術集会)

藤原謙次, 大内田研宙, 進藤幸治, 赤川進, 江口大樹, 小薗真吾, 池永直樹, 崔林, 相島慎一, 大塚隆生, 高畑俊一, 水元一博, 小田義直, 田中雅夫

日本外科学会雑誌 2012.3

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PS-007-2 胃癌におけるトラスツズマブ治療のためのHER2判定上の問題点と対応(PS-007 胃基礎-3,ポスターセッション,第112回日本外科学会定期学術集会)

鴻江俊治, 久松雄一, 神代竜一, 中西良太, 安藤幸滋, 佐伯浩司, 沖英次, 大賀丈史, 掛地吉弘, 池田哲夫, 辻谷俊一, 相島慎一, 前原喜彦

日本外科学会雑誌 2012.3

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PS-060-5 Tissue Tablet(組織タブレット)法 : 手術切除組織の保存・管理のための新しいアプローチ(PS-060 医療安全,第112回日本外科学会定期学術集会)

寅田信博, 大内田研宙, 崔林, 水元一博, 相島慎一, 小田義直, 田中雅夫

日本外科学会雑誌 2012.3

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PS-101-7 腸型膵管内乳頭粘液性腫瘍(IPMN)由来浸潤性膵臓癌の予後が良好な理由(PS-101 膵 IPMN,ポスターセッション,第112回日本外科学会定期学術集会)

仲田興平, 大内田研宙, 貞苅良彦, 萱島理, 相島慎一, 水元一博, 小田義直, 田中雅夫

日本外科学会雑誌 2012.3

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SF-026-2 腫瘍関連マクロファージによる肝細胞癌のSignal Transducer and Activator of Transcription 3(STAT3)活性化と増殖進展における役割(SF-026 サージカルフォーラム(26)肝基礎-2,第112回日本外科学会定期学術集会)

間野洋平, 相島慎一, 吉屋匠平, 武藤純, 的野る美, 本村貴志, 戸島剛男, 武冨紹信, 調憲, 前原喜彦

日本外科学会雑誌 2012.3

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SF-030-4 通常型膵癌を併存する膵管内乳頭粘液性腫瘍は胃型粘液形質を有する頻度が高い(SF-030 サージカルフォーラム(30)膵基礎-1(発癌,癌進展),第112回日本外科学会定期学術集会)

井手野昇, 大塚隆生, 小田康徳, 河野博, 安蘇鉄平, 永吉洋介, 森泰寿, 相島慎一, 大内田研宙, 高畑俊一, 中村雅史, 水元一博, 田中雅夫

日本外科学会雑誌 2012.3

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Total resection of the right hepatic vein drainage area with the aid of three-dimensional computed tomography.

Akinobu Taketomi, Kazuki Takeishi, Yohei Mano, Takeo Toshima, Takashi Motomura, Shinichi Aishima, Hideaki Uchiyama, Tomoharu Yoshizumi, Ken Shirabe, Yoshihiko Maehara

Surgery today 2012.1

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DOI： 10.1007/s00595-011-0021-8
An increase in the number of predictive factors augments the likelihood of malignancy in branch duct intraductal papillary mucinous neoplasm of the pancreas.

Takao Ohtsuka, Hiroshi Kono, Yosuke Nagayoshi, Yasuhisa Mori, Kosuke Tsutsumi, Yoshihiko Sadakari, Shunichi Takahata, Katsuya Morimatsu, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kousei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

Surgery 2012.1

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DOI： 10.1016/j.surg.2011.07.009
Uptake of Gd-EOB-DTPA by hepatocellular carcinoma: radiologic-pathologic correlation with special reference to bile production.

Yoshiki Asayama, Tsuyoshi Tajima, Akihiro Nishie, Kousei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, Daisuke Okamoto, Nobuhiro Fujita, Shinichi Aishima, Ken Shirabe, Hiroshi Honda

European journal of radiology 2011.12

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DOI： 10.1016/j.ejrad.2010.10.032
Nuclear atypia grading score is a useful prognostic factor in papillary gastric adenocarcinoma.

Yuichiro Nakashima, Takashi Yao, Minako Hirahashi, Shinichi Aishima, Yoshihiro Kakeji, Yoshihiko Maehara, Masazumi Tsuneyoshi

Histopathology 2011.11

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DOI： 10.1111/j.1365-2559.2011.04035.x
Histological and immunohistological findings in biliary intraepithelial neoplasia arising from a background of chronic biliary disease compared with liver cirrhosis of non-biliary aetiology.

Shinichi Aishima, Tomohiro Iguchi, Nobuhiro Fujita, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi, Yoshinao Oda

Histopathology 2011.11

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DOI： 10.1111/j.1365-2559.2011.04011.x
MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis.

Kohei Nakata, Kenoki Ohuchida, Kazuhiro Mizumoto, Tadashi Kayashima, Naoki Ikenaga, Hiroshi Sakai, Cui Lin, Hayato Fujita, Takao Otsuka, Shinichi Aishima, Eishi Nagai, Yoshinao Oda, Masao Tanaka

Surgery 2011.11

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DOI： 10.1016/j.surg.2011.06.017
広範微小肺腫瘍塞栓によって呼吸不全を来たした肝細胞癌患者の一例

田中紘介, 中舎晃男, 宮崎将之, 高尾信一郎, 樋口野日斗, 田中正剛, 田中ゆき, 加藤正樹, 古藤和浩, 髙栁涼一, 相島慎一

福岡醫學雜誌 2011.10

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肝細胞癌の肝外転移臓器として，肺は最も頻度の高い臓器である．CT やMR などの画像検査機器の発達により，肺転移巣の同定は容易となり，その診断に苦慮することは希である．また，肝細胞癌からの肺転移は高頻度であるにもかかわらず，呼吸不全に至る症例は少なく，多くの場合，肺転移巣が拡大して呼吸機能に影響を与えるようになる前に，原発の肝病変が進行して，肝不全に至る．今回我々は，肝細胞癌の経過観察中に，原因不明の呼吸不全が急速に進行した症例を経験した．入院時の画像検査で，肺の腫瘍性病変などの呼吸不全を来たす所見を認めず，酸素化が障害されている原因が不明であったが，死後の肺組織検査により，広範な微小腫瘍塞栓が認められた．肺の腫瘍塞栓によって，急速な呼吸不全を来たす病態として，Pulmonary tumor thrombotic microangiopathy（PTTM）があるが，本症例の病理所見では，PTTM は否定的であった．本症例の呼吸不全に関して若干の文献的考察を加えて報告する．

DOI： 10.15017/20445
Histologic classification of microscopic portal venous invasion to predict prognosis in hepatocellular carcinoma.

Nobuhiro Fujita, Shinichi Aishima, Tomohiro Iguchi, Yohei Mano, Akinobu Taketomi, Ken Shirabe, Hiroshi Honda, Masazumi Tsuneyoshi, Yoshinao Oda

Human pathology 2011.10

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DOI： 10.1016/j.humpath.2010.12.016
Cystic tumors of the liver: on the problems of diagnostic criteria.

Yohei Mano, Shinichi Aishima, Nobuhiro Fujita, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

Pathology, research and practice 2011.10

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DOI： 10.1016/j.prp.2011.07.006
PS-129-6 腫瘍関連マクロファージによる肝細胞癌のSignal Transducer and Activated of Transcription 3 (STAT3)活性化と臨床病理学的検討(PS-129 ポスターセッション(129)肝臓:基礎-4,第111回日本外科学会定期学術集会)

間野洋平, 相島慎一, 調憲, 藤田展宏, 武藤純, 的野る美, 本村貴志, 武石一樹, 戸島剛男, 吉松正憲, 伊地知秀樹, 原田昇, 内山秀昭, 吉住朋晴, 武冨紹信, 前原喜彦

日本外科学会雑誌 2011.5

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PS-096-5 当科における大腸癌肝転移に対する術前化学療法の検討(PS-096 ポスターセッション(96)大腸:化学療法-3,第111回日本外科学会定期学術集会)

山中直樹, 奈良絵津子, 安蘇鉄平, 真鍋達也, 植木隆, 森松克哉, 相島慎一, 藤本千夏, 馬場英司, 田中雅夫

日本外科学会雑誌 2011.5

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Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis.

Kohei Nakata, Kenoki Ohuchida, Shinichi Aishima, Yoshihiko Sadakari, Tadashi Kayashima, Yoshihiro Miyasaka, Eishi Nagai, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi, Yoshinao Oda

Pancreas 2011.5

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DOI： 10.1097/MPA.0b013e318214fa86
大動脈原発 Intimal sarcoma の1例

山田裕一, 山元英崇, 相島慎一, 田宮貞史, 西田誉浩, 富永隆治, 小田義直

診断病理 : Japanese journal of diagnostic pathology 2011.4

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Different roles of S100P overexpression in intrahepatic cholangiocarcinoma: carcinogenesis of perihilar type and aggressive behavior of peripheral type.

Shinichi Aishima, Nobuhiro Fujita, Yohei Mano, Yuichiro Kubo, Yuki Tanaka, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

The American journal of surgical pathology 2011.4

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DOI： 10.1097/PAS.0b013e31820ffdf1
Prognostic significance of preoperative imaging in recipients of living donor liver transplantation for hepatocellular carcinoma.

Keishi Sugimachi, Ken Shirabe, Akinobu Taketomi, Yuji Soejima, Tomohiro Iguchi, Kazuki Takeishi, Takeo Toshima, Shinichi Aishima, Tsuyoshi Tajima, Yoshihiko Maehara

Transplantation 2011.3

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DOI： 10.1097/TP.0b013e318208134e
Performance of radiological methods in diagnosing hepatocellular carcinoma preoperatively in a recipient of living related liver transplantation: comparison with step section histopathology.

Masakazu Hirakawa, Kengo Yoshimitsu, Hiroyuki Irie, Tsuyoshi Tajima, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Akinobu Taketomi, Shin-ichi Aishima, Hiroshi Honda

Japanese journal of radiology 2011.2

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DOI： 10.1007/s11604-010-0528-8
Pseudo-Meigs' syndrome associated with breast cancer metastasis to both ovaries: Report of a case.

Naonori Kawakubo, Masayuki Okido, Risa Tanaka, Kenji Mitsugi, Masao Fukuhara, Shinichi Aishima, Masato Kato, Hitoshi Ichimiya

Surgery today 2010.12

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DOI： 10.1007/s00595-009-4187-2
Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type.

2010.12

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Ovarian mucinous neoplasms of gastro-intestinal type (GI-type) are known to be a heterogeneous tumor composed of benign, borderline and non-invasive and invasive malignant lesions. The presence of infiltrative invasion is also known to be an important prognostic factor of this neoplasm. Laminin γ 2 chain, known to stimulate tumor cell invasion and migration, has not been sufficiently investigated in ovarian mucinous neoplasms. The purpose of this study was thus to clarify the role of laminin γ 2 in ovarian mucinous neoplasms of GI-type. We selected each morphological phase of tumor development from 61 cases of mucinous neoplasms of the GI-type: 55 adenoma lesions, 60 borderline lesions, 20 microinvasive lesions, 17 intraepithelial carcinoma lesions, 38 expansile invasive carcinoma lesions, 19 infiltrative invasive carcinoma lesions and 5 mural nodules lesions; and evaluated the localization of laminin γ 2 in the lesions using immunohistochemical method. The staining pattern was classified into i) basement membranous (BM), ii) cytoplasmic (CYT) and iii) stromal (S) pattern. The BM pattern was characteristic in adenoma, borderline, and interaepithelial and expansile invasive carcinoma lesions. The CYT and S patterns were characteristic in infiltrative invasive lesions. The staining pattern of mural nodules was similar to that of infiltrative invasion. The infiltrative invasion of GI-type ovarian mucinous neoplasms may be promoted by cytoplasmic and/or stromal expression of laminin γ 2 chain.

DOI： 10.3892/or-00001019
Predictors of extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma.

Akinobu Taketomi, Takeo Toshima, Dai Kitagawa, Takashi Motomura, Kazuki Takeishi, Yohei Mano, Hiroto Kayashima, Keishi Sugimachi, Shinichi Aishima, Yoichi Yamashita, Toru Ikegami, Tomonobu Gion, Hideaki Uchiyama, Yuji Soejima, Takashi Maeda, Ken Shirabe, Yoshihiko Maehara

Annals of surgical oncology 2010.10

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DOI： 10.1245/s10434-010-1076-2
p62+ Hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease.

Shinichi Aishima, Nobuhiro Fujita, Yohei Mano, Tomohiro Iguchi, Akinobu Taketomi, Yoshihiko Maehara, Yoshinao Oda, Masazumi Tsuneyoshi

American journal of clinical pathology 2010.9

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DOI： 10.1309/AJCP53YVVJCNDZIR
肝細胞腺腫の1例

平島浩太郎, 本田由美, 石原園子, 安里嗣晴, 赤星慎一, 近本亮, 別府透, 馬場秀夫, 相島慎一, 猪山賢一

診断病理 : Japanese journal of diagnostic pathology 2010.7

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Clinicopathological prognostic factors after hepatectomy for patients with mass-forming type intrahepatic cholangiocarcinoma: relevance of the lymphatic invasion index.

Ken Shirabe, Yohei Mano, Akinobu Taketomi, Yuji Soejima, Hideaki Uchiyama, Shinichi Aishima, Hiroto Kayashima, Mizuki Ninomiya, Yoshihiko Maehara

Annals of surgical oncology 2010.7

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DOI： 10.1245/s10434-010-0929-z
S100P is a novel marker to identify intraductal papillary mucinous neoplasms.

Kohei Nakata, Eishi Nagai, Kenoki Ohuchida, Akifumi Hayashi, Yoshihiro Miyasaka, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi

Human pathology 2010.6

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DOI： 10.1016/j.humpath.2009.11.007
Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinoma.

Akifumi Hayashi, Shinichi Aishima, Takahiro Inoue, Kohei Nakata, Katsuya Morimatsu, Eishi Nagai, Yoshinao Oda, Masao Tanaka, Masazumi Tsuneyoshi

Human pathology 2010.6

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DOI： 10.1016/j.humpath.2009.09.018
Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development.

Nobuhiro Fujita, Shinichi Aishima, Tomohiro Iguchi, Yunosuke Nishihara, Hidetaka Yamamoto, Akinobu Taketomi, Yoshinao Oda, Hiroshi Honda, Masazumi Tsuneyoshi

Human pathology 2010.6

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DOI： 10.1016/j.humpath.2009.11.011
Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from the intestinal type.

Yoshihiko Sadakari, Kenoki Ohuchida, Kohei Nakata, Takao Ohtsuka, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

Surgery 2010.6

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DOI： 10.1016/j.surg.2009.11.011
11.類奇形腫成分を伴った肝芽腫の1例(第39回九州地区小児固形悪性腫瘍研究会)

孝橋,賢一, 小田,義直, 相島,慎一, 田尻,達郎, 林田,真, 田口,智章, 神薗,淳司, 小野,友輔

小児がん : 小児悪性腫瘍研究会記録 2010.5

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臨床報告術前診断が困難であった肝硬化性血管腫の1切除例

吉田月久, 杉町圭史, 祇園智信, 副島雄二, 相島慎一, 武冨紹信, 前原喜彦

臨床外科 2010.3

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DOI： 10.11477/mf.1407103016
OP-078-2 肝内胆管癌切除症例の生存に関わる因子の解析と治療成績向上への取り組み(胆管癌治療-2,一般口演,第110回日本外科学会定期学術集会)

本村貴志, 間野洋平, 調憲, 武石一樹, 戸島剛男, 梅田健一, 森田和豊, 萱島寛人, 二宮瑞樹, 内山秀昭, 副島雄二, 武冨紹信, 相島慎一, 山下洋一, 前原喜彦

日本外科学会雑誌 2010.3

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OP-257-2 腫瘤形成型を示す肝内胆管癌の浸潤形式と予後の検討(肝胆道・病理-1,一般口演,第110回日本外科学会定期学術集会)

関野洋平, 調憲, 本村貴志, 武石和樹, 戸島剛男, 森田和豊, 萱島寛人, 二宮瑞樹, 内山秀昭, 副島雄二, 武冨紹信, 相島慎一, 前原喜彦

日本外科学会雑誌 2010.3

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Unusual multiple gastric carcinoids with hypergastrinemia: report of a case.

Kohei Nakata, Shinichi Aishima, Hitoshi Ichimiya, Takashi Yao, Takashi Matsuura, Mitsuru Seo, Eishi Nagai, Masayuki Okido, Masato Kato, Mitsuru Nakagaki, Masazumi Tsuneyoshi, Masao Tanaka

Surgery today 2010.3

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DOI： 10.1007/s00595-009-4032-7
Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement.

Yasuni Nakanuma, Yoh Zen, Kenichi Harada, Motoko Sasaki, Akitaka Nonomura, Takeshi Uehara, Kenji Sano, Fukuo Kondo, Toshio Fukusato, Koichi Tsuneyama, Masahiro Ito, Kenichi Wakasa, Minoru Nomoto, Hiroshi Minato, Hironori Haga, Masayoshi Kage, Hirohisa Yano, Joji Haratake, Shinichi Aishima, Tomoyuki Masuda, Hajime Aoyama, Aya Miyakawa-Hayashino, Toshiharu Matsumoto, Hayato Sanefuji, Hidenori Ojima, Tse-Ching Chen, Eunsil Yu, Ji-Hun Kim, Young Nyun Park, Wilson Tsui

Pathology international 2010.3

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DOI： 10.1111/j.1440-1827.2009.02500.x
Fascin expression in progression and prognosis of hepatocellular carcinoma.

Tomohiro Iguchi, Shinichi Aishima, Kenji Umeda, Kensaku Sanefuji, Nobuhiro Fujita, Keishi Sugimachi, Tomonobu Gion, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Journal of surgical oncology 2009.12

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DOI： 10.1002/jso.21377
CD10+ fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma.

Yunosuke Nishihara, Shinichi Aishima, Akifumi Hayashi, Tomohiro Iguchi, Nobuhiro Fujita, Akinobu Taketomi, Hiroshi Honda, Masazumi Tsuneyoshi

Histopathology 2009.10

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DOI： 10.1111/j.1365-2559.2009.03398.x
P-1-368 肝細胞癌における被膜浸潤の新定義とその検証(肝腫瘍基礎,一般演題(ポスター),第64回日本消化器外科学会総会)

井口友宏, 相島慎一, 森田和豊, 植田茂, 實藤健作, 杉町圭史, 祇園智信, 武冨紹信, 前原喜彦

日本消化器外科学会雑誌 2009.7

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P-1-285 大腸癌卵巣転移によるpseudo-Meigs症候群3例の臨床病理学的検討(大腸癌症例1,一般演題(ポスター),第64回日本消化器外科学会総会)

大西秀哉, 相島慎一, 松本耕太郎, 許斐裕之, 大城戸政行, 加藤雅人, 一宮仁

日本消化器外科学会雑誌 2009.7

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LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer.

Kohei Nakata, Kenoki Ohuchida, Eishi Nagai, Akifumi Hayashi, Yoshihiro Miyasaka, Tadashi Kayashima, Jun Yu, Shinichi Aishima, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi

Neoplasia (New York, N.Y.) 2009.7

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DOI： 10.1593/neo.09418
Erratum: Extracapsular penetration is a new prognostic factor in human hepatocellular carcinoma (American Journal of Surgical Pathology (2008) 32 (1675-1682))

T. Iguchi, S. Aishima, A. Taketomi

American Journal of Surgical Pathology 2009.3

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DOI： 10.1097/PAS.0b013e31819f584d
Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma.

Shinichi Aishima, Tomohiro Iguchi, Yunosuke Nishihara, Nobuhiro Fujita, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Histopathology 2009.3

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DOI： 10.1111/j.1365-2559.2009.03240.x
SF-057-1 肝内胆管癌における癌関連遺伝子発現とSurvival tree model解析による予後予測(肝(基礎研究3),サージカルフォーラム,第109回日本外科学会定期学術集会)

井口友宏, 山下夏美, 相島慎一, 實藤健作, 杉町圭史, 武冨紹信, 恒吉正澄, 前原喜彦

日本外科学会雑誌 2009.2

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SF-041-4 腸型IPMN発がん経路におけるCDX2を介したRegIVの関与(膵(IPMN),サージカルフォーラム,第109回日本外科学会定期学術集会)

仲田興平, 永井英司, 大内田研宙, 相島慎一, 森松克哉, 林晃史, 宮坂義弘, 水元一博, 恒吉正澄, 田中雅夫

日本外科学会雑誌 2009.2

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Fascin overexpression is involved in carcinogenesis and prognosis of human intrahepatic cholangiocarcinoma: immunohistochemical and molecular analysis.

Tomohiro Iguchi, Shinichi Aishima, Akinobu Taketomi, Yunosuke Nishihara, Nobuhiro Fujita, Kensaku Sanefuji, Keishi Sugimachi, Yo-ichi Yamashita, Yoshihiko Maehara, Masazumi Tsuneyoshi

Human pathology 2009.2

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DOI： 10.1016/j.humpath.2008.06.029
ヒト悪性腫瘍の病理組織形態と分子生物学的特性

恒吉正澄, 八尾隆史, 小田義直, 田宮貞史, 相島慎一, 山元英崇, 大石善丈, 平橋美奈子, 栗原秀一, 孝橋賢一

福岡醫學雜誌 2009.1

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DOI： 10.15017/13540
Biliary phenotype of hepatocellular carcinoma after preoperative transcatheter arterial chemoembolization.

Yunosuke Nishihara, Shinichi Aishima, Yousuke Kuroda, Tomohiro Iguchi, Kenichi Taguchi, Yoshiki Asayama, Akinobu Taketomi, Naoko Kinukawa, Hiroshi Honda, Masazumi Tsuneyoshi

Journal of gastroenterology and hepatology 2008.12

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DOI： 10.1111/j.1440-1746.2008.05601.x
CD10 immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium.

Yoshihiro Ohishi, Tsunehisa Kaku, Hiroaki Kobayashi, Shinichi Aishima, Yoshihisa Umekita, Norio Wake, Masazumi Tsuneyoshi

Human pathology 2008.10

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DOI： 10.1016/j.humpath.2008.02.006
O-2-183 肝細胞癌におけるFascin発現の臨床病理学的意義(肝研究3,一般演題(口演),第63回日本消化器外科学会総会)

井口友宏, 西原雄之介, 藤田展宏, 相島慎一, 杉町圭史, 山下洋市, 武冨紹信, 慎吉正澄, 前原喜彦

日本消化器外科学会雑誌 2008.7

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特集小腸疾患2008 各論 4.全身性疾患の部分症としての小腸病変 5) 免疫不全-移植片対宿主病(graft-versus-host disease;GVHD),後天性免疫不全症候群(acquired immunodeficiency syndrome;AIDS)

瀬尾充, 金玹志, 西条寛平, 松浦隆志, 相島慎一, 衛藤徹也, 中山秀樹

胃と腸 2008.4

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DOI： 10.11477/mf.1403101353
DP-114-4 肝細胞癌におけるFascin発現の臨床病理学的意義(第108回日本外科学会定期学術集会)

井口友宏, 西原雄之介, 藤田展宏, 相島慎一, 杉町圭史, 山下洋市, 武冨紹信, 恒吉正澄, 前原喜彦

日本外科学会雑誌 2008.4

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DP-137-4 肝内胆管癌におけるFocal Adhesion Kinase (FAK)発現の臨床的意義(第108回日本外科学会定期学術集会)

大田隆司, 武冨紹信, 森田和豊, 福原崇介, 植田茂, 實藤健作, 萱島寛人, 丸山晴司, 杉町圭史, 山下洋市, 吉住朋晴, 副島雄二, 相島慎一, 前原喜彦

日本外科学会雑誌 2008.4

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Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma.

Shinichi Aishima, Yunosuke Nishihara, Tomohiro Iguchi, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008.3

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DOI： 10.1038/modpathol.3800985
Arterial blood supply of hepatocellular carcinoma and histologic grading: radiologic-pathologic correlation.

Yoshiki Asayama, Kengo Yoshimitsu, Yunosuke Nishihara, Hiroyuki Irie, Shinichi Aishima, Akinobu Taketomi, Hiroshi Honda

AJR. American journal of roentgenology 2008.1

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DOI： 10.2214/AJR.07.2117
Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine.

Nobito Higuchi, Masaki Kato, Kazuhiro Kotoh, Motoyuki Kohjima, Shinichi Aishima, Makoto Nakamuta, Yoshinori Fukui, Ryoichi Takayanagi, Munechika Enjoji

Liver international : official journal of the International Association for the Study of the Liver 2007.12

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DOI： 10.1111/j.1478-3231.2007.01590.x
P-587 ゲフィチニブで著効を得た後肺葉切除を行い良好に経過中の2例(一般演題(ポスター) 症例11,第48回日本肺癌学会総会号)

加藤雅人, 安蘇鉄平, 園田幸生, 上田純二, 大城戸政行, 一宮仁, 中垣充, 鶴田伸子, 樋口和行, 相島慎一

肺癌 2007.10

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Expression profile of class I histone deacetylases in human cancer tissues.

Masamune Nakagawa, Yoshinao Oda, Takashi Eguchi, Shin-Ichi Aishima, Takashi Yao, Fumihito Hosoi, Yuji Basaki, Mayumi Ono, Michihiko Kuwano, Masao Tanaka, Masazumi Tsuneyoshi

Oncology reports 2007.10

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DOI： 10.3892/or.18.4.769
P-2-304 原発性胆汁性肝硬変を背景に発症した肝細胞癌3症例の病理学的検討(肝癌臨床3,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

黒田陽介, 武冨紹信, 相島慎一, 北川大, 伊藤心二, 原田昇, 山下洋市, 池上徹, 副島雄二, 前原喜彦

日本消化器外科学会雑誌 2007.7

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Role of growth factor receptor bound protein 7 in hepatocellular carcinoma.

Shinji Itoh, Akinobu Taketomi, Shinji Tanaka, Norifumi Harimoto, Yo-ichi Yamashita, Shin-ichi Aishima, Takashi Maeda, Ken Shirabe, Mitsuo Shimada, Yoshihiko Maehara

Molecular cancer research : MCR 2007.7

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DOI： 10.1158/1541-7786.MCR-06-0282
14-3-3sigma negatively regulates the cell cycle, and its down-regulation is associated with poor outcome in intrahepatic cholangiocarcinoma.

Yousuke Kuroda, Shinichi Aishima, Akinobu Taketomi, Yunosuke Nishihara, Tomohiro Iguchi, Kenichi Taguchi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Human pathology 2007.7

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DOI： 10.1016/j.humpath.2006.12.014
Hepatoid adenocarcinoma of the stomach: histogenesis and progression in association with intestinal phenotype.

Yumiko Kumashiro, Takashi Yao, Shinichi Aishima, Minako Hirahashi, Kenichi Nishiyama, Tomomi Yamada, Ryoichi Takayanagi, Masazumi Tsuneyoshi

Human pathology 2007.6

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DOI： 10.1016/j.humpath.2006.10.020
Histologic characteristics and prognostic significance in small hepatocellular carcinoma with biliary differentiation: subdivision and comparison with ordinary hepatocellular carcinoma.

Shinichi Aishima, Yunosuke Nishihara, Yousuke Kuroda, Kenichi Taguchi, Tomohiro Iguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

The American journal of surgical pathology 2007.5

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DOI： 10.1097/01.pas.0000213421.53750.0a
A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease.

Tohru Utsunomiya, Masahiro Okamoto, Shigeki Wakiyama, Masaji Hashimoto, Kengo Fukuzawa, Takahiro Ezaki, Shinichi Aishima, Yasuji Yoshikawa, Taizo Hanai, Hiroshi Inoue, Graham-F Barnard, Masaki Mori

World journal of gastroenterology 2007.1

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DOI： 10.3748/wjg.v13.i3.383
Proposal of a new staging and grading system of the liver for primary biliary cirrhosis

K. Hiramatsu, H. Aoyama, Y. Zen, S. Aishima, S. Kitagawa, Y. Nakanuma

Histopathology 2006.11

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DOI： 10.1111/j.1365-2559.2006.02537.x
Characteristic differences according to the cirrhotic pattern of advanced primary biliary cirrhosis: Macronodular cirrhosis indicates slow progression.

Shinichi Aishima, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Hepatology research : the official journal of the Japan Society of Hepatology 2006.11

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DOI： 10.1016/j.hepres.2006.07.008
High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma.

Shinichi Aishima, Yuji Basaki, Yoshinao Oda, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Fumihito Hosoi, Yuichiro Maruyama, Abbas Fotovati, Shinji Oie, Mayumi Ono, Takato Ueno, Michio Sata, Hirohisa Yano, Masamichi Kojiro, Michihiko Kuwano, Masazumi Tsuneyoshi

Cancer science 2006.11

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DOI： 10.1111/j.1349-7006.2006.00322.x
Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: Gastric foveolar type is associated with aggressive tumour behaviour

S. Aishima, Y. Kuroda, Y. Nishihara, K. Taguchi, A. Taketomi, Y. Maehara, M. Tsuneyoshi

Histopathology 2006.7

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DOI： 10.1111/j.1365-2559.2006.02414.x
肝内胆管癌における術後予後規定因子の解析と治療戦略

播本憲史, 武冨紹信, 吉住朋晴, 内山秀昭, 山下洋市, 原田昇, 北川大, 黒田陽介, 萱島寛人, 相島慎一, 前原喜彦

日本外科学会雑誌 2006.3

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Prognostic impact of cholangiocellular and sarcomatous components in combined hepatocellular and cholangiocarcinoma.

Shinichi Aishima, Yousuke Kuroda, Yoshiki Asayama, Kenichi Taguchi, Yunosuke Nishihara, Akinobu Taketomi, Masazumi Tsuneyoshi

Human pathology 2006.3

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DOI： 10.1016/j.humpath.2005.08.019
医学集談会臨床病理検討会(肺癌を合併した特発性間質性肺炎の1例)

金田章子, 松永悠子, 相島慎一

共済医報 2006.2

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記事種別: 会議・学会報告・シンポジウム
今月の症例胃inflammatory fibroid polypの1例

檜沢一興, 中原束, 住吉康平, 森山智彦, 松本主之, 飯田三雄, 相島慎一, 八尾隆史

胃と腸 2006.2

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DOI： 10.11477/mf.1403100265
[Mechanism of biliary carcinogenesis: Hepatotropic hepatis virus].

Kenichi Taguchi, Shinichi Aishima, Masazumi Tsuneyoshi

Nihon rinsho. Japanese journal of clinical medicine 2006.1

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Significance of the relationship between irregular regeneration and two hepatocarcinogenic pathways: "de novo" and so-called "dysplastic nodule-hepatocellular carcinoma" sequence.

Kenichi Taguchi, Shinichi Aishima, Shuji Matsuura, Takahiro Terashi, Kenichi Nishiyama, Ken Shirabe, Mitsuo Shimada, Yoshihiko Maehara, Masazumi Tsuneyoshi

Journal of surgical oncology 2005.11

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DOI： 10.1002/jso.20293
サイトメガロウイルス感染症と出血性直腸潰瘍を合併した成人スチル病の1例

檜沢一興, 相島慎一, 八尾隆史, 中原束, 松本主之, 飯田三雄

日本消化器病学会雑誌 2005.10

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症例は84歳女性．成人スチル病の診断でステロイド治療中に大量下血を生じ，2003年6月4日，当科緊急入院となった．直腸に巨大潰瘍あり，生検組織像にて虚血性変化と薬剤性粘膜障害の所見を認めた．さらにCMVantigenemia陽性のためgancyclovir併用し，中心静脈栄養療法を継続した．経過中antigenemia再上昇にともない下血が再燃した．gancyclovir継続後は下血なく，2004年3月16日，成人スチル病のため死亡した．

DOI： 10.11405/nisshoshi.102.1281
'Scirrhous' type hepatocellular carcinomas: A special reference to expression of cytokeratin 7 and hepatocyte paraffin 1

S. Matsuura, S. Aishima, K. Taguchi, Y. Asayama, T. Terashi, H. Honda, Masazumi Tsuneyoshi

Histopathology 2005.10

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DOI： 10.1111/j.1365-2559.2005.02230.x
Bronchiolitis obliterans organizing pneumonia as an initial manifestation in systemic lupus erythematosus.

Hidetoshi Takada, Yusuke Saito, Akihiko Nomura, Shouichi Ohga, Kazuyoshi Kuwano, Nobutaka Nakashima, Shinichi Aishima, Noboru Tsuru, Toshiro Hara

Pediatric pulmonology 2005.9

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DOI： 10.1002/ppul.20224
LMD法とDNAマイクロアレイ法による肝細胞癌の癌化進展関連遺伝子についての検討(肝臓10, 第60回日本消化器外科学会総会)

岡本正博, 宇都宮徹, 原口直紹, 三森功士, 田中文明, 脇山茂樹, 福澤謙吾, 相島慎一, 井上裕, 森正樹

日本消化器外科学会雑誌 2005.7

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Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement.

Yoh Zen, Shinichi Aishima, Yoichi Ajioka, Joji Haratake, Masayoshi Kage, Fukuo Kondo, Yuji Nimura, Michiie Sakamoto, Motoko Sasaki, Kazuhide Shimamatsu, Kenichi Wakasa, Young Nyun Park, Ming F Chen, Yutaka Atomi, Yasuni Nakanuma

Pathology international 2005.4

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DOI： 10.1111/j.1440-1827.2005.01816.x
Detection of combined hepatocellular and cholangiocarcinomas on enhanced CT: comparison with histologic findings.

Akihiro Nishie, Kengo Yoshimitsu, Yoshiki Asayama, Hiroyuki Irie, Hitoshi Aibe, Tsuyoshi Tajima, Kenji Shinozaki, Tomohiro Nakayama, Daisuke Kakihara, Mitsuo Shimada, Shin-Ichi Aishima, Kisaku Yoshida, Hiroshi Honda

AJR. American journal of roentgenology 2005.4

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DOI： 10.2214/ajr.184.4.01841157
バルプロ酸ナトリウムにより高アンモニア血症をきたしたC型慢性肝炎の1例

福嶋真理恵, 古藤和浩, 遠城寺宗近, 中牟田誠, 名和田新, 相島慎一

日本消化器病学会雑誌 2005.1

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症例は45歳，男性．平成10年より慢性硬膜血腫術後のてんかん発作にて，近医経過観察中，高アンモニア血症を指摘され，平成13年5月当科に紹介入院．HCV-RNA陽性だが肝予備能低下なく，門脈大循環へのシャントなく，アミノ酸分析正常であった．薬剤の関与としてバルプロ酸ナトリウムが考えられ，減量中止したところアンモニア値は改善した．基礎病変として肝疾患を持つ症例においても，常に薬剤による高アンモニア血症に考慮して診療にあたるべきと考えられた．

DOI： 10.11405/nisshoshi.102.42, 10.2957/kanzo.59.421_references_DOI_7iqc9gI6LrFzakFaQecy4g2pG30
Aberrant expression of laminin gamma 2 chain and its prognostic significance in intrahepatic cholangiocarcinoma according to growth morphology Reviewed

Shinichi Aishima, Shuji Matsuura, Takahiro Terashi, Kenichi Taguchi, Mitsuo Shimada, Yoshihiko Maehara, Masazumi Tsuneyoshi

Modern Pathology 2004.8

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DOI： 10.1038/modpathol.3800143
The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C.

Norifumi Harimoto, Mitsuo Shimada, Shin-ichi Aishima, Dai Kitagawa, Shinji Itoh, Eiji Tsujita, Shin-ichiro Maehara, Akinobu Taketomi, Shinji Tanaka, Ken Shirabe, Yoshihiko Maehara

Liver international : official journal of the International Association for the Study of the Liver 2004.8

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DOI： 10.1111/j.1478-3231.2004.0927.x
OP-3-018 肝細胞癌におけるDGKθ発現の生物学的意義に関する研究(肝9)

武冨紹信, 島田光生, 辻田英司, 相島慎一, 北川大, 田中真二, 調憲, 前原喜彦

日本消化器外科学会雑誌 2004.7

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Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma.

Shinji Itoh, Takashi Maeda, Mitsuo Shimada, Shin-ichi Aishima, Ken Shirabe, Shinji Tanaka, Yoshihiko Maehara

Clinical cancer research : an official journal of the American Association for Cancer Research 2004.4

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DOI： 10.1158/1078-0432.CCR-1046-03
Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis.

Ken Shirabe, Mitsuo Shimada, Eiji Tsujita, Shin-ichi Aishima, Shin-ichiroh Maehara, Sinji Tanaka, Kenji Takenaka, Yoshihiko Maehara

American journal of surgery 2004.4

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DOI： 10.1016/j.amjsurg.2003.12.044
SF-048-5 肝細胞癌におけるシグナル伝達物質Grb7発現の検討

伊藤心二, 島田光生, 田中真二, 調憲, 武冨紹信, 相島慎一, 前原喜彦

日本外科学会雑誌 2004.3

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Decreased expression of osteopontin is related to tumor aggressiveness and clinical outcome of intrahepatic cholangiocarcinoma.

Takahiro Terashi, Shinichi Aishima, Kenichi Taguchi, Yoshiki Asayama, Keishi Sugimachi, Shuji Matsuura, Mitsuo Shimada, Shinichiro Maehara, Yoshihiko Maehara, Masazumi Tsuneyoshi

Liver international : official journal of the International Association for the Study of the Liver 2004.2

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DOI： 10.1111/j.1478-3231.2004.00886.x
懇話会第376回北九州肝臓病懇話会

天ヶ瀬洋正, 相島慎一, 梶原英二

臨牀と研究 = The Japanese journal of clinical and experimental medicine 2003.11

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記事種別: 特集 ; 会議・学会報告・シンポジウム
Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma

K. Sugimachi, S. Tanaka, K. Taguchi, S. Aishima, M. Shimada, K. Sugimachi, M. Tsuneyoshi

Journal of Clinical Pathology 2003.11

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DOI： 10.1136/jcp.56.11.854
肝細胞癌におけるfocal adhesion kinaseの生物学的意義に関する研究

伊藤心二, 島田光生, 前田貴司, 相島慎一, 田中真二, 調憲, 恒吉正澄, 前原喜彦

日本消化器外科学会雑誌 2003.7

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特集全身性疾患と消化管病変総論 4. 病理学的側面からみた全身性疾患と消化管病変

八尾隆史, 西山憲一, 相島慎一, 恒吉正澄

胃と腸 2003.4

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DOI： 10.11477/mf.1403100899
Sarcomatous hepatocellular carcinoma: a special reference to ordinary hepatocellular carcinoma.

Hidehiro Nishi, Ken-ichi Taguchi, Yoshiki Asayama, Shin-ichi Aishima, Keishi Sugimachi, Hajime Nawata, Masazumi Tsuneyoshi

Journal of gastroenterology and hepatology 2003.4

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DOI： 10.1046/j.1440-1746.2003.02888.x
Coexpression of neural cell adhesion molecules and bcl-2 in intrahepatic cholangiocarcinoma originated from viral hepatitis: relationship to atypical reactive bile ductule.

Yoshiki Asayama, Shin-Ichi Aishima, Ken-Ichi Taguchi, Keishi Sugimachi, Shuji Matsuura, Kouji Masuda, Masazumi Tsuneyoshi

Pathology international 2002.4

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DOI： 10.1046/j.1440-1827.2002.01349.x
The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma.

Shin-ichi Aishima, Ken-ichi Taguchi, Keishi Sugimachi, Yoshiki Asayama, Hidehiro Nishi, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

International journal of surgical pathology 2002.1

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DOI： 10.1177/106689690201000108
Intrahepatic cholangiocarcinoma: its mode of spreading and therapeutic modalities.

Ken Shirabe, Mitsuo Shimada, Norifumi Harimoto, Keishi Sugimachi, Yo-ichi Yamashita, Eiji Tsujita, Shin-ichi Aishima

Surgery 2002.1

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DOI： 10.1067/msy.2002.119498
S05-04 肝内胆管癌に対する切除の問題点と戦略

調憲, 島田光生, 竹中賢治, 田中真二, 山下洋市, 相島慎一, 杉町圭蔵

日本消化器外科学会雑誌 2001.7

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The role of des-γ-carboxy prothrombin levels in hepatocellular carcinoma and liver tissues

2000.10

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We aimed to clarify the clinical significance of des-γ-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC, who underwent hepatectomy, were studied. Surgical specimens were obtained from both HCC and non-cancerous liver of each patient. After the preparation of the liver tissues, including tissues with HCC, the DCP levels both in HCC and non-cancerous liver tissue were measured using an electro-chemiluminescence immunoassay. The correlation was investigated between DCP levels and other clinicopathological factors. The DCP level of HCC ranged from 55 to 77 735 U/0.1 g tissue weight, with a median of 2801, while the DCP level of non-cancerous parts of the liver ranged from 24 to 721 U/0.1 g tissue weight, with a median of 86. The DCP level in the liver tissue in patients having a multicentric occurrence of HCC was significantly higher than that in patients without multicentric occurrence of HCC. The logarithm of the plasma DCP level correlated with that of the DCP level in HCC (correlation coefficient = 0.46; P < 0.05). No significant correlation was found between the DCP level in HCC and other clinicopathological parameters. The DCP level in non-cancerous parts of the liver with simultaneous multicentric occurrence of HCC was significantly higher than that in the liver without multicentric HCC. Furthermore, the DCP level in non-cancerous parts of the liver was one of the most important predictable factors of the multicentric occurrence of HCCs among various clinicopathological factors. Therefore, the DCP level may have an important role in hepatocarcinogenesis. (C) 2000 Elsevier Science Ireland Ltd.

DOI： 10.1016/S0304-3835(00)00539-5
Clinicopathologic features and postoperative prognosis of multicentric small hepatocellular carcinoma

Tohru Utsunomiya, Mitsuo Shimada, Ken Ichi Taguchi, Hirofumi Hasegawa, Yoichi Yamashita, Takayuki Hamatsu, Shin Ichi Aishima, Keizo Sugimachi

Journal of the American College of Surgeons 2000.3

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DOI： 10.1016/S1072-7515(99)00268-9
W2-3 肝細胞癌におけるMAGE遺伝子の発現および再発関連因子としての検討

濱津隆之, 島田光生, 宇都宮徹, 田口健一, 長谷川博文, 山下洋市, 相島慎一, 調憲, 杉町圭蔵

日本消化器外科学会雑誌 1999.6

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W7-2 小肝細胞癌に対する外科治療戦略 : 径3cm未満単発小肝細胞癌の肝切除成績の検討

濱津隆之, 島田光生, 宇都宮徹, 祇園智信, 田口健一, 長谷川博文, 山下洋市, 相島慎一, 杉町圭蔵

日本消化器外科学会雑誌 1999.2

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S6-4 再発肝細胞癌に対する戦略 : 再切除における予後因子の検討から

島田光生, 宇都宮徹, 祇園智信, 田口健一, 長谷川博文, 山下洋市, 濱津隆之, 相島慎一, 竹中賢治, 杉町圭蔵

日本消化器外科学会雑誌 1999.2

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664 5生率から高度進行肝癌の治療戦略

山下洋市, 島田光生, 宇都宮徹, 祇園智信, 田口健一, 長谷川博文, 相島慎一, 濱津隆之, 杉町圭蔵

日本消化器外科学会雑誌 1999.2

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Professional Memberships

日本外科学会
日本消化器外科学会
日本病理学会
日本癌学会
日本肝臓学会
日本臨床細胞学会
日本臨床細胞学会

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日本肝臓学会

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日本癌学会

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日本病理学会

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日本消化器外科学会

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Committee Memberships

日本病理学会生涯教育委員会委員長

2022.4 - Present

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日本病理学会功労会員・名誉会員資格審査委員会委員

2024.4 - Present

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日本臨床細胞学会評議員

2023.6 - Present

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The International Academy of Pathology Japanese Division director

2022.11 - Present

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日本病理学会希少がん病理診断支援検討委員会委員

2020.4 - Present

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国際病理アカデミー日本支部教育委員会委員

2018.11 - Present

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日本病理学会学術評議員資格審査委員会委員

2018.4 - Present

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日本病理学会 Pathology International 刊行委員会委員

2017.1 - Present

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日本病理学会病理医・研究医の育成とリクルート委員会委員

2016.4 - Present

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日本臨床細胞学会佐賀県支部理事長

2016.4 - 2023.6

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Research Projects

ex vivo還流培養による精緻な組織構築を実現したミニチュアヒト肝臓の創成

Grant number：23K08143 2023.4 - 2026.3

科学研究費助成事業基盤研究(C)

山下洋市, 井嶋博之, 米満吉和, 相島慎一

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胆汁分泌など薬物動態を踏まえた薬剤スクリーニング、およびドナー不足解消のための新規
移植グラフトを目指したミニチュアヒト肝臓の創成を目指して医工連携研究を行う。ヒト初代培養細胞やヒトiPS細胞から得る機能性ヒト細胞（肝細胞・胆管細胞）、臓器構築のscaffoldとなる内皮化されたラット脱細胞鋳型肝臓を組み合わせて臓器工学システムを構築する。更に、極小型人工肺モジュールを用いた高酸素供給が可能なex-vivo培養回路を作製し、ミニチュアヒト肝臓を灌流培養して、高い肝組織構築（肝小葉・類洞形成）を実現する。

CiNii Research
肝内胆管癌のサブタイプ別にみる分子異常と免疫微小環境の包括的研究

Grant number：22K06942 2022 - 2024

日本学術振興会科学研究費助成事業基盤研究(C)

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医工連携によるミニチュアヒト肝臓創成とそのex vivo培養がもたらす革新的医療

Grant number：20H03744 2020.4 - 2023.3

科学研究費助成事業基盤研究(B)

山下洋市, 井嶋博之, 馬場秀夫, 米満吉和, 相島慎一

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1)ヒト初代培養細胞やヒトiPS細胞から『機能性ヒト細胞（肝細胞・胆管細胞）』を得る。
2)細胞の包埋に用いる『機能性ヘパリン導入ゼラチンゲル基剤』を最適化する。
3)臓器構築のscaffoldとなる『内皮化されたラット脱細胞鋳型肝臓』を組み合わせて臓器工学システムを構築する。ミニチュアヒト肝臓を灌流培養して、高い肝組織構築 (肝小葉・類洞形成)を実現する。
4)新規医療展開を目指し、ミニチュアヒト肝臓のex-vivo培養システムにて薬剤代謝スクリーニングを行う。また、ミニチュアヒト肝臓を免疫不全ラットへ移植して肝特異機能を評価する。

CiNii Research
直接抗ウイルス剤によるウイルス排除後肝癌における免疫微小環境の病理学的研究

Grant number：19K07462 2019 - 2022

日本学術振興会科学研究費助成事業基盤研究(C)

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ミニチュアヒト肝臓を用いた肝癌の浸潤・転移機序解明による革新的肝癌治療の開発

Grant number：16K10586 2016 - 2018

日本学術振興会科学研究費助成事業基盤研究(C)

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肝・胆道癌の発癌・進展における鉄代謝関連蛋白発現調節機構の病理学的解明

Grant number：15K08347 2015 - 2018

日本学術振興会科学研究費助成事業基盤研究(C)

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肝癌の微小環境における炎症の機序解明とＰＤ－１シグナル制御による革新的治療の開発

Grant number：24390320 2012 - 2014

日本学術振興会科学研究費助成事業基盤研究(C)

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胆管癌における胆管レベルによる発癌・進展機構の違い：胆汁酸受容体と糖代謝に関して

Grant number：23590399 2011 - 2013

日本学術振興会科学研究費助成事業基盤研究(C)

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慢性肝炎・肝硬変に生じる肝内胆管癌の発癌機構の解明

Grant number：21790355 2009 - 2010

日本学術振興会科学研究費助成事業基盤研究(C)

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肝細胞癌浸潤・転移におけるFascin蛋白の機能解析とその臨床応用

Grant number：20591614 2008 - 2010

日本学術振興会科学研究費助成事業基盤研究(C)

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肝内胆管癌の浸潤・転移における細胞接着分子の発現とその制御機構の解明

Grant number：17790237 2005

日本学術振興会科学研究費助成事業基盤研究(C)

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肝内胆管癌の浸潤転移

2003 - 2004

日本学術振興会科学研究費助成事業基盤研究(C)

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肝内胆管癌における多段階発癌・発育進展機序の解明

Grant number：15790187 2003 - 2004

日本学術振興会科学研究費助成事業基盤研究(C)

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Class subject

病理学総論老化皮膚・膠原病

2024.4 - 2024.9 First semester
病理学各論肝胆膵病理学

2023.10 - 2024.3 Second semester

FD Participation

2024.3 Role：Participation Title：大学病院の苦悩と医学研究の課題

Organizer：[Undergraduate school/graduate school/graduate faculty]

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

2024 群馬大学・医学部 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：令和6年4月23日

Other educational activity and Special note

2024 Class Teacher