OIKE MASAHIRO
Organization
Faculty of Medical Sciences Department of Basic Medicine Associate Professor
School of Medicine Department of Medicine（Concurrent）
Graduate School of Medical Sciences Department of Medicine（Concurrent）
Graduate School of Medical Sciences Department of Medical Sciences（Concurrent）
School of Medicine Department of Medicine（Concurrent）
Graduate School of Medical Sciences Department of Medicine（Concurrent）
Graduate School of Medical Sciences Department of Medical Sciences（Concurrent）
Title
Associate Professor
Contact information
Tel
0926426076
Profile
Research:
(1) Vascular endothelium: My main research interest is endothelial signal transduction. I have clarified mechanosensitive endothelial responses, focusing on ATP release mechanisms. Furthermore, I have examined the effects of various hazardous environments, such as hypoxia, glucose overload and hyperlipidemia, on endothelial functions.
(2) I have developed an in vitro reconstruction system of smooth muscle contraction, using cultured smooth muscle cells, and examined the detailed contractile mechanisms of vascular and airway smooth muscle cells. Especially I have established the in vitro model system of airway hyperresponsiveness and revealed the possible involvement of RhoA and MMP-1 in hyperresponsiveness.
(3) in silico drug discovery: I have been using in sillico screening for discovering anti-metastatic drugs.
(4) I have developed in silico drug repositioning system and have been conducting experiments to prove the usefulness of this system.
(5) I have developed a novel in silico method to design small proteins that can show therapeutic properties.
Education:
I give lectures of introduction to pharmacology, autonomic pharmacology, CNS pharmacology, endocrine pharmacology, pharmacology of blood coagulation, pulmonary pharmacology and gastrointestinal pharmacology to undergraduate medical students (3rd grade), and provide practices in pharmacodynamics using simulation programs, and in pharmacokinetics using model case.
External link
Degree
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PhD
Research History
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1991年4月-1992年5月 稲築病院内科 1994年4月-11月 飯塚病院内科
1991年4月-1992年5月 稲築病院内科 1994年4月-11月 飯塚病院内科
Research Interests・Research Keywords
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Research theme： Designing of small molecule proteins that have therapeutic potentials.
Keyword： small molecule proteins, in silico drug development, therapeutic activities
Research period： 2021.3
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Research theme： Development of medium molecular weight compounds targeting protein-protein interface.
Keyword： protein-protein interaction, in silico drug development, medium molecular weight compounds
Research period： 2018.4 - 2022.3
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Research theme： Drug repositioning using in silico screening.
Keyword： in silico screening, drug repositioning
Research period： 2016.4
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Research theme： Prediction of drug-target proteins using computational chemistry.
Keyword： computational chemistry, drug target, protein, in silico screening
Research period： 2015.10 - 2018.3
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Research theme： Drug discovery using in silico screening.
Keyword： in silico screening, cancer metastasis, TGFβ
Research period： 2013.4
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Research theme： Interaction between vascular endothelial cells and tumor cells.
Keyword： endothelial cells, tumor cells, protein
Research period： 2008.9 - 2014.12
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Research theme： Exploration of endogenous anti-angiogenic substance.
Keyword： angiogenesis, endothelial cells, anti-angiogenic factor, protein
Research period： 2007.9 - 2019.3
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Research theme： Identification of endogenous smooth muscle organization factor.
Keyword： vascular smooth muscle cells, intercellular information
Research period： 2005.4 - 2015.3
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Research theme： Possible role of MMP-1 in the Th2 cytokines-induced development of airway hyperresponsiveness.
Keyword： Th2 cytokines, MMP-1, airway hyperresponsiveness, collagen
Research period： 2005.4 - 2012.12
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Research theme： Molecular mechanisms of airway hyperresponsiveness and exploration of anti-hyperresponsive drugs.
Keyword： airway smooth muscle cells, airway hyperresponsiveness, theophylline, cAMP, small G protein.
Research period： 2000.4 - 2006.12
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Research theme： Molecular mechanisms of endothelial mechanosensitivity.
Keyword： vascular endothelial cells, small G protein, ATP, Dbl protein, integrin
Research period： 1998.4 - 2014.4
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Research theme： ATP release pathway in vascular endothleial cells.
Keyword： vascular endothelial cells, ATP release, chloride channels
Research period： 1996.4 - 2002.12
Papers
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Endothelium-dependent epithelial-mesenchymal transition of tumor cells: Exclusive roles of transforming growth factor β1 and β2. Reviewed International journal
Chiwaka Kimura, Masayuki Hayashi, Yuri Mizuno, Masahiro Oike
Biochim Biophys Acta 1830 ( 10 ) 4470 - 4481 2013.10
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Transforming growth factor β1 alters calcium mobilizing properties and endogenous ATP release in A549 cells: possible implications for cell migration. Reviewed International journal
Kenji Miki, Hiromitsu Tanaka, Yoko Nagai, Chiwaka Kimura, Masahiro Oike
Journal of Pharmacological Sciences 113 ( 4 ) 2010.8
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Dual modulation of airway smooth muscle contraction by Th2 cytokines via matrix metalloproteinase-1 production. Reviewed International journal
Ohta Y, Hayashi M, Kanemaru T, Abe K, Ito Y, Oike M.
Journal of Immunology 2008.3
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Proapoptotic nitric oxide production in amyloid beta protein-treated cerebral microvascular endothelial cells Reviewed International journal
Kimura C, Oike M, Watanabe M, and Ito Y
Microcirculation 2007.2
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Pivotal role of integrin alpha5beta1 in hypotonic stress-induced responses of human endothelium. Reviewed International journal
Hirakawa M, Oike M, Watanabe M, Karashima Y, Ito Y
FASEB Journal 2006.12
Books
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Annual Review 2006 呼吸器 「気道平滑筋の生物学」
伊東祐之、大池正宏、小西秀平（Role：Joint author）
中外医学社 2006.1
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Histamine Research in the New Millenium. "Glucose overload attenuates histamine H2 receptor-mediated Ca2+ mobilization due to protein kinase C production in bovine cerebral endothelial cells."
Oike M, Kimura C, Ito Y（Role：Joint author）
Elsevier 2001.1
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ベッドサイドの薬理学
有岡将基、池松秀之、上野 晋、江頭伸昭、大池正宏、栗原 崇、笹栗俊之、高橋富美、樗木晶子、西 昭徳、宮田篤郎、吉原達也（Role：Joint author）
丸善出版 2018.4
Presentations
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国産無償創薬ソフトを使った臨床からの新薬再開発の提案 Invited
大池正宏
第55回日本生物物理学会 2017.9
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血管及びリンパ管内皮からの恒常的なTGFβの分泌とその腫瘍細胞における上皮間葉移行への関与 Invited
大池 正宏, 木村千稚
第88回日本薬理学会年会 2015.3
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myPrestoを用いた医学生へのインシリコ創薬教育とその意義
大池 正宏, 木村千稚, @福西快文
第90回日本薬理学会年会 2017.3
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インシリコ手法による新規機序の低分子TGFβ1阻害薬開発の試み
大池 正宏, 木村千稚
第89回日本薬理学会年会 2016.3
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SARS-CoV-2スパイク蛋白の受容体結合部位と結合する人工抗体の開発
大池正宏、@高橋宏隆、@澤崎達也
第95回日本薬理学会年会 2022.3
MISC
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コンピューターシミュレーションによる動物実習の代替
大池 正宏
日本薬理学会雑誌 2014.1
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血管内皮細胞におけるATP放出経路
大池正宏、Droogmans G、伊東祐之
日本薬理学会雑誌 2004.6
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血管内皮細胞における一酸化窒素の産生機構および治療ターゲットとしての意義
大池正宏
福岡医学雑誌 2000.10
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血管平滑筋収縮の概観
伊東祐之、井上隆司、大池正宏、森田浩光
生体の科学 2006.11
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気道平滑筋と気管支収縮
大池正宏、伊東祐之
呼吸 2004.3
Professional Memberships
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The Chem-Bio Informatics Society
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The Japanese Pharmacological Society
Committee Memberships
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日本平滑筋学会 Councilor Domestic
2006.7 - Present
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日本薬理学会 Councilor Domestic
1996.3 - Present
Academic Activities
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Screening of academic papers
Role(s)： Peer review
2021
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Screening of academic papers
Role(s)： Peer review
2020
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Screening of academic papers
Role(s)： Peer review
2019
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「イノベーション創出強化研究推進事業」（旧 農食事業）課題１次(書面)審査等に係る評議委員
Role(s)： Review, evaluation
公益社団法人 農林水産・食品産業技術振興協会 2018.12 - 2019.3
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座長（Chairmanship）
第71回日本薬理学会西南部会 （ Japan ） 2018.11
Research Projects
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中和抗体様作用をもつ低分子化合物創出の試み
Grant number：25670129 2013 - 2014
Grants-in-Aid for Scientific Research Grant-in-Aid for Exploratory Research
Authorship：Principal investigator Grant type：Scientific research funding
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抗体を用いた癌転移再発抑制療法の開発
2011
研究成果最適展開支援プログラム A-STEP フィージビリティスタディ ステージ 探索タイプ
Authorship：Principal investigator Grant type：Contract research
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宇宙環境利用に関する地上研究－三次元スフェロイド培養による微小重力環境での細胞機能解析法の開発
2007.2 - 2009.3
日本宇宙フォーラム（日本）
Authorship：Principal investigator
This study aims to develop an efficient method for cell culture in space station.
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Th2サイトカインによる全く新しい気道過敏性発生機序の分子薬理学的研究
Grant number：19390065 2007 - 2008
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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三次元スフェロイド培養による微小重力環境での細胞機能解析法の開発
2006 - 2008
日本宇宙フォーラム 第9回 宇宙環境利用に関する地上研究 宇宙利用先駆研究
Authorship：Principal investigator Grant type：Contract research
Educational Activities
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Postgraduates (graduate school of medical sciences): I have supervised nine postgraduate students, one research students and three researchers from China and Korea. Eight students have been awarded Ph.D. or M.Sc. degree already.
Undergraduate class (faculty of medicine, department of medicine): I give lectures of pharmacology to undergraduate medical students (21hours), and conduct practice of pharmacology (8hours).
(faculty of medicine, department of biomedical science): I give lecture of biological response and regulation (5hours).
Class subject
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系統生命科学II：生体応答制御学
2023.10 - 2024.3 Second semester
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系統医学II：薬理学（総論）
2023.4 - 2023.9 First semester
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系統医学II：薬理学（各論）
2023.4 - 2023.9 First semester
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系統生命科学II：薬理学 (総論)
2023.4 - 2023.9 First semester
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生体応答制御学
2022.10 - 2023.3 Second semester
FD Participation
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2022.8 Role：Participation Title：医学部医学科・生命科学科FD
Organizer：Undergraduate school department
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2021.8 Role：Participation Title：医学部医学科・生命科学科FD
Organizer：Undergraduate school department
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2020.8 Role：Participation Title：医学部医学科・生命科学科FD
Organizer：Undergraduate school department
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2019.8 Role：Participation Title：医学部医学科・生命科学科FD
Organizer：Undergraduate school department
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2018.8 Role：Participation Title：医学部医学科・生命科学科FD
Organizer：Undergraduate school department
Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.
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2018 第一薬科大学 薬学部 Classification:Part-time lecturer Domestic/International Classification:Japan
Semester, Day Time or Duration：後期後半 火曜1・2時限、金曜1・2眼
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2017 第一薬科大学 薬学部 Classification:Part-time lecturer Domestic/International Classification:Japan
Semester, Day Time or Duration：後期後半 火曜1・2時限、金曜1・2眼
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2016 第一薬科大学 薬学部 Classification:Part-time lecturer Domestic/International Classification:Japan
Semester, Day Time or Duration：後期後半 火曜1・2時限、金曜1・2眼
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2015 第一薬科大学 薬学部 Classification:Part-time lecturer Domestic/International Classification:Japan
Semester, Day Time or Duration：後期 火曜1・2時限
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2014 第一薬科大学 薬学部 Classification:Part-time lecturer Domestic/International Classification:Japan
Semester, Day Time or Duration：後期 火曜1・2時限
Other educational activity and Special note
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2021 Class Teacher 学部
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2020 Class Teacher 学部
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2020 Special Affairs I introduced a use of computer simulation programs as an alternative to animal use in pharmacology education (Folia Pharmacologica Japonica. 144(2), 95-97, 2014).
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2019 Class Teacher 学部
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2019 Class Teacher 学部
Outline of Social Contribution and International Cooperation activities
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There would be various changes in vascular functions in microgravity, and therefore clinical courses of cardiovascular diseases and malignancy of astronauts may be different from those on earth, especially in a long term. I have examined the effects of gravity on endothelial functions especially mechanosensitivity as research commissions with Japan Aerospace Exploration Agency.
Year of medical license acquisition
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1985