Humanized GPIbalpha-von Willebrand factor interaction in the mouse Reviewed International journal

Kanaji S, Orje JN, Kanaji T, Kamikubo Y, Morodomi Y, Chen Y, Zarpellon A, Eberhardt J, Forli S, Fahs SA, Sood R, Haberichter SL, Montgomery RR, Ruggeri ZM

Blood Adv   2 ( 19 )   2522   2018.10

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia Reviewed International journal

Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha A, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P

Proc Natl Acad Sci U S A   115 ( 35 )   E8228   2018.8

Non-myeloablative conditioning with busulfan before hematopoietic stem cell transplantation leads to phenotypic correction of murine Bernard- Soulier syndrome Reviewed International journal

Kanaji S, Fahs SA, Ware J, Montgomery RR, Shi Q

J Thromb Haemost   12 ( 10 )   1726   2014.10

Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia Reviewed International journal

Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ

Blood   122 ( 15 )   2732   2013.10

Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis Reviewed International journal

Kanaji S, Fahs SA, Shi Q, Haberichter SL, Montgomery RR

J Thromb Haemost   10 ( 8 )   1646   2012.8

Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy Reviewed International journal

Kanaji S, Kuether EL, Fahs SA, Schroeder JA, Ware J, Montgomery RR, Shi Q

Mol Ther   20 ( 3 )   625   2012.3

Identification of four novel mutations in F5 associated with congenital factor V deficiency Reviewed International journal

Kanaji S, Kanaji T, Honda M, Nakazato S, Wakayama K, Tabata Y, Shibata S, Gondo H, Nakamura I, Node K, Miura M, Miyahara M, Okamura T, Nagumo F, Ohta S, Izuhara K

Int J Hematol   89 ( 1 )   71   2009.1

Characterization of a patient with atypical amegakaryocytic thrombocytopenia Reviewed International journal

Kanaji S, Kanaji T, Migita M, Kunishima S, Kunicki TJ, Okamura T, Izuhara K

Eur J Haematol   80 ( 4 )   361   2008.4

Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases Reviewed International journal

Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K

FEBS Lett   581 ( 22 )   4260   2007.9

Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation Reviewed International journal

Kanaji S, Kanaji T, Jacquelin B, Chang M, Nugent DJ, Komatsu N, Moroi M, Izuhara K, Kunicki TJ

Blood   105 ( 10 )   3888   2005.5

Convulxin binds to native, human glycoprotein Ib alpha Reviewed International journal

Kanaji S, Kanaji T, Furihata K, Kato K, Ware JL, Kunicki TJ

J Biol Chem   278 ( 41 )   39452   2003.10

The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion Reviewed International journal

Kato K, Kanaji T, Russell S, Kunicki TJ, Furihata K, Kanaji S, Marchese P, Reininger A, Ruggeri ZM, Ware J

Blood   102 ( 5 )   1701   2003.9

Identification and characterization of two novel mutations (Q421 K and R123P) in congenital factor XII deficiency Reviewed International journal

Kanaji T, Kanaji S, Osaki K, Kuroiwa M, Sakaguchi M, Mihara K, Niho Y, Okamura T

Thromb Haemost   86 ( 6 )   1409   2001.12

Characterization of the signal that directs Tom20 to the mitochondrial outer membrane Reviewed International journal

Kanaji S, Iwahashi J, Kida Y, Sakaguchi M, Mihara K

J Cell Biol   151 ( 2 )   277   2000.10

Hemophagocytic syndrome associated with fulminant ulcerative colitis and presumed acute pancreatitis Reviewed International journal

Kanaji S, Okuma K, Tokumitsu Y, Yoshizawa S, Nakamura M, Niho Y

Am J Gastroenterol   93 ( 10 )   1956   1998.10

Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic "integrated stress response" Reviewed International journal

Jones JA, Wei N, Cui H, Shi Y, Fu G, Rauniyar N, Shapiro R, Morodomi Y, Berenst N, Dumitru CD, Kanaji S, Yates JR, 3rd, Kanaji T, Yang XL

Cell Rep   42 ( 6 )   112632   2023.6

Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia Reviewed International journal

Sun J, Uchiyama S, Olson J, Morodomi Y, Cornax I, Ando N, Kohno Y, Kyaw MMT, Aguilar B, Haste NM, Kanaji S, Kanaji T, Rose WE, Sakoulas G, Marth JD, Nizet V

Sci Transl Med   13 ( 586 )   eabd6737   2021.3

Extracellular tyrosyl-tRNA synthetase cleaved by plasma proteinases and stored in platelet alpha-granules: Potential role in monocyte activation Reviewed International journal

Won E, Morodomi Y, Kanaji S, Shapiro R, Vo MN, Orje JN, Thornburg CD, Yang XL, Ruggeri ZM, Schimmel P, Kanaji T

Res Pract Thromb Haemost   4 ( 7 )   1167   2020.9

von Willebrand factor variant D1472H has no effect in mice with humanized VWF-platelet interactions Reviewed International journal

Lohmeier HK, Slobodianuk TL, Kanaji S, Haberichter SL, Montgomery RR, Flood VH

Blood Adv   4 ( 17 )   4065   2020.9

Modified application of Kawamoto's film method for super-resolution imaging of megakaryocytes in undecalcified bone marrow Reviewed International journal

Morodomi Y, Kanaji S, Won E, Kawamoto T, Kanaji T

Res Pract Thromb Haemost   4 ( 1 )   86   2019.11

von Willebrand factor propeptide to antigen ratio identifies platelet activation and reduced von Willebrand factor survival phenotype in mice Reviewed International journal

Jacobi PM, Kanaji S, Jakab D, Gehrand AL, Johnsen JM, Haberichter SL

J Thromb Haemost   16 ( 3 )   546   2018.3

Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiven Reviewed International journal

Ito T, Suzuki S, Kanaji S, Shiraishi H, Ohta S, Arima K, Tanaka G, Tamada T, Honjo E, Garcia KC, Kuroki R, Izuhara K

J Biol Chem 284   284 ( 36 )   24289   2009.9

A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells Reviewed International journal

Sonoda E, Aoki S, Uchihashi K, Soejima H, Kanaji S, Izuhara K, Satoh S, Fujitani N, Sugihara H, Toda S

Endocrinology   149 ( 10 )   4794   2008.10

Expression of the extracellular region of the human interleukin-4 receptor alpha chain and interleukin-13 receptor alpha1 chain by a silkworm-baculovirus system Reviewed International journal

Honjo E, Shoyama Y, Tamada T, Shigematsu H, Hatanaka T, Kanaji S, Arima K, Ito Y, Izuhara K, Kuroki R

Protein Expr Purif   60 ( 1 )   25   2008.7

Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease Reviewed International journal

Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Shiraki A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K

J Immunol   180 ( 9 )   6262   2008.5

Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2 Reviewed International journal

Cheli Y, Kanaji S, Jacquelin B, Chang M, Nugent DJ, Kunicki TJ

Biochim Biophys Acta   1769 ( 9-10 )   546   2007.9

Involvement of IL-32 in activation-induced cell death in T cells Reviewed International journal

Goda C, Kanaji T, Kanaji S, Tanaka G, Arima K, Ohno S, Izuhara K

Int Immunol   18 ( 2 )   233   2006.2

Characterization of the interaction between interleukin-13 and interleukin-13 receptors Reviewed International journal

Arima K, Sato K, Tanaka G, Kanaji S, Terada T, Honjo E, Kuroki R, Matsuo Y, Izuhara K

J Biol Chem   280 ( 26 )   24915   2005.7

Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells Reviewed International journal

Tanaka G, Kanaji S, Hirano A, Arima K, Shinagawa A, Goda C, Yasunaga S, Ikizawa K, Yanagihara Y, Kubo M, Kuriyama-Fujii Y, Sugita Y, Inokuchi A, Izuhara K

Int Immunol   17 ( 6 )   797   2005.6

Characterization of Inherited Differences in Transcription of the Human Integrin alpha 2 Gene Reviewed International journal

Jacquelin B, Rozenshteyn D, Kanaji S, Koziol JA, Nurden AT, Kunicki TJ

J Biol Chem   276 ( 26 )   23518   2001.6

Severe left ventricular dysfunction in a patient with primary Sjogren's syndrome Reviewed

Takaoka (Kanaji) S, Higuchi M, Odashiro K, Yoshizawa S, Horiuchi T, Niho Y

20 ( 3 )   199   1997.6

IL-13 and its signal pathway: promising targets in the development of a therapeutic agent for bronchial asthma Reviewed

Izuhara K, Arima K, Kanaji S, Kanaji T, Ohta S

Curr Signal Transduction Therapy   2007.5

IL-13: a promising therapeutic target for bronchial asth Reviewed

Izuhara K, Arima K, Kanaji S, Ohta S, Kanaji T

Curr Med Chem   2006.5

IL-4 and IL-13: Their pathological roles in allergic diseases and their potential in developing new therapies - Update Reviewed

Izuhara K, Arima K, Masumoto K, Kanaji S, Kanaji T

Med Chem. Rev   2005.5

IL-4/IL-13のダイオキシン類感受性への影響 Reviewed

金地佐千子、田中剛、出原賢治

臨床免疫   2005.5

IL-4/IL-13と気管支喘息 Reviewed

金地佐千子、出原賢治

喘息   2004.5

American Society of Hematology

インターロイキン-13を標的としたアレルギー疾患治療戦略の開発

Grant number：16790555  2004 - 2005

科学研究費助成事業  若手研究(A,B)

IL‐4,IL‐13のシグナル伝達機構解析に基づくアレルギー疾患発症機序の解明

Grant number：15591058  2003 - 2004

日本学術振興会  科学研究費助成事業  基盤研究(C)