Updated on 2024/07/28

Information

 

写真a

 
KANAJI SACHIKO
 
Organization
Faculty of Medical Sciences Department of Basic Medicine Associate Professor
School of Medicine Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medical Sciences(Joint Appointment)
Title
Associate Professor
Contact information
メールアドレス
Tel
0926425750

Degree

  • MD, PhD

Awards

  • Prof. Heimburger Award

    2012.4   CSL Behring  

  • Postdoctoral Fellowship Award

    2010.1   American Heart Association (AHA)  

Papers

  • Circulating immune cells with megakaryocyte signature in response to COVID-19 mRNA vaccination Reviewed International journal

    Kanaji T, Morodomi Y, Kanaji S

    Thromb Res   220   1   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.thromres.2022.10.003

  • Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection Reviewed International journal

    Morodomi Y, Kanaji S, Sullivan BM, Zarpellon A, Orje JN, Won E, Shapiro R, Yang XL, Ruf W, Schimmel P, Ruggeri ZM, Kanaji T

    Proc Natl Acad Sci U S A   119 ( 48 )   e2212659119   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.2212659119

  • The impact of aberrant von Willebrand factor-GPIbα interaction on megakaryopoiesis and platelets in humanized type 2B von Willebrand disease model mouse Reviewed International journal

    107 ( 9 )   2133   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3324/haematol.2021.280561

  • Detection of anti-GPIbα autoantibodies in a case of immune thrombocytopenia following COVID-19 vaccination Reviewed International journal

    209   80   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.thromres.2021.11.030

  • Mechanisms of anti-GPIbalpha antibody-induced thrombocytopenia in mice Reviewed International journal

    Morodomi Y, Kanaji S, Won E, Ruggeri ZM, Kanaji T

    Blood   135 ( 25 )   2292   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood.2019003770

  • Humanized GPIbalpha-von Willebrand factor interaction in the mouse Reviewed International journal

    Kanaji S, Orje JN, Kanaji T, Kamikubo Y, Morodomi Y, Chen Y, Zarpellon A, Eberhardt J, Forli S, Fahs SA, Sood R, Haberichter SL, Montgomery RR, Ruggeri ZM

    Blood Adv   2 ( 19 )   2522   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/bloodadvances.2018023507

  • Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia Reviewed International journal

    Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha A, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P

    Proc Natl Acad Sci U S A   115 ( 35 )   E8228   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.1807000115

  • Non-myeloablative conditioning with busulfan before hematopoietic stem cell transplantation leads to phenotypic correction of murine Bernard- Soulier syndrome Reviewed International journal

    Kanaji S, Fahs SA, Ware J, Montgomery RR, Shi Q

    J Thromb Haemost   12 ( 10 )   1726   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jth.12673

  • Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia Reviewed International journal

    Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ

    Blood   122 ( 15 )   2732   2013.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2013-06-510461

  • Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis Reviewed International journal

    Kanaji S, Fahs SA, Shi Q, Haberichter SL, Montgomery RR

    J Thromb Haemost   10 ( 8 )   1646   2012.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1538-7836.2012.04797.x

  • Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy Reviewed International journal

    Kanaji S, Kuether EL, Fahs SA, Schroeder JA, Ware J, Montgomery RR, Shi Q

    Mol Ther   20 ( 3 )   625   2012.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/mt.2011.231

  • Identification of four novel mutations in F5 associated with congenital factor V deficiency Reviewed International journal

    Kanaji S, Kanaji T, Honda M, Nakazato S, Wakayama K, Tabata Y, Shibata S, Gondo H, Nakamura I, Node K, Miura M, Miyahara M, Okamura T, Nagumo F, Ohta S, Izuhara K

    Int J Hematol   89 ( 1 )   71   2009.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-008-0210-4

  • Characterization of a patient with atypical amegakaryocytic thrombocytopenia Reviewed International journal

    Kanaji S, Kanaji T, Migita M, Kunishima S, Kunicki TJ, Okamura T, Izuhara K

    Eur J Haematol   80 ( 4 )   361   2008.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-0609.2008.01029.x

  • Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases Reviewed International journal

    Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K

    FEBS Lett   581 ( 22 )   4260   2007.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.febslet.2007.07.072

  • Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation Reviewed International journal

    Kanaji S, Kanaji T, Jacquelin B, Chang M, Nugent DJ, Komatsu N, Moroi M, Izuhara K, Kunicki TJ

    Blood   105 ( 10 )   3888   2005.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2004-08-3109

  • Convulxin binds to native, human glycoprotein Ib alpha Reviewed International journal

    Kanaji S, Kanaji T, Furihata K, Kato K, Ware JL, Kunicki TJ

    J Biol Chem   278 ( 41 )   39452   2003.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M300199200

  • The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion Reviewed International journal

    Kato K, Kanaji T, Russell S, Kunicki TJ, Furihata K, Kanaji S, Marchese P, Reininger A, Ruggeri ZM, Ware J

    Blood   102 ( 5 )   1701   2003.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2003-03-0717

  • Identification and characterization of two novel mutations (Q421 K and R123P) in congenital factor XII deficiency Reviewed International journal

    Kanaji T, Kanaji S, Osaki K, Kuroiwa M, Sakaguchi M, Mihara K, Niho Y, Okamura T

    Thromb Haemost   86 ( 6 )   1409   2001.12

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  • Characterization of the signal that directs Tom20 to the mitochondrial outer membrane Reviewed International journal

    Kanaji S, Iwahashi J, Kida Y, Sakaguchi M, Mihara K

    J Cell Biol   151 ( 2 )   277   2000.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1083/jcb.151.2.277

  • Hemophagocytic syndrome associated with fulminant ulcerative colitis and presumed acute pancreatitis Reviewed International journal

    Kanaji S, Okuma K, Tokumitsu Y, Yoshizawa S, Nakamura M, Niho Y

    Am J Gastroenterol   93 ( 10 )   1956   1998.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 0.1111/j.1572-0241.1998.00554.x

  • Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic "integrated stress response" Reviewed International journal

    Jones JA, Wei N, Cui H, Shi Y, Fu G, Rauniyar N, Shapiro R, Morodomi Y, Berenst N, Dumitru CD, Kanaji S, Yates JR, 3rd, Kanaji T, Yang XL

    Cell Rep   42 ( 6 )   112632   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2023.112632

  • Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia Reviewed International journal

    Sun J, Uchiyama S, Olson J, Morodomi Y, Cornax I, Ando N, Kohno Y, Kyaw MMT, Aguilar B, Haste NM, Kanaji S, Kanaji T, Rose WE, Sakoulas G, Marth JD, Nizet V

    Sci Transl Med   13 ( 586 )   eabd6737   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scitranslmed.abd6737

  • Extracellular tyrosyl-tRNA synthetase cleaved by plasma proteinases and stored in platelet alpha-granules: Potential role in monocyte activation Reviewed International journal

    Won E, Morodomi Y, Kanaji S, Shapiro R, Vo MN, Orje JN, Thornburg CD, Yang XL, Ruggeri ZM, Schimmel P, Kanaji T

    Res Pract Thromb Haemost   4 ( 7 )   1167   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/rth2.12429

  • von Willebrand factor variant D1472H has no effect in mice with humanized VWF-platelet interactions Reviewed International journal

    Lohmeier HK, Slobodianuk TL, Kanaji S, Haberichter SL, Montgomery RR, Flood VH

    Blood Adv   4 ( 17 )   4065   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/bloodadvances.2020002629

  • Modified application of Kawamoto's film method for super-resolution imaging of megakaryocytes in undecalcified bone marrow Reviewed International journal

    Morodomi Y, Kanaji S, Won E, Kawamoto T, Kanaji T

    Res Pract Thromb Haemost   4 ( 1 )   86   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/rth2.12276

  • von Willebrand factor propeptide to antigen ratio identifies platelet activation and reduced von Willebrand factor survival phenotype in mice Reviewed International journal

    Jacobi PM, Kanaji S, Jakab D, Gehrand AL, Johnsen JM, Haberichter SL

    J Thromb Haemost   16 ( 3 )   546   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jth.13934

  • Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiven Reviewed International journal

    Ito T, Suzuki S, Kanaji S, Shiraishi H, Ohta S, Arima K, Tanaka G, Tamada T, Honjo E, Garcia KC, Kuroki R, Izuhara K

    J Biol Chem 284   284 ( 36 )   24289   2009.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M109.007286

  • A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells Reviewed International journal

    Sonoda E, Aoki S, Uchihashi K, Soejima H, Kanaji S, Izuhara K, Satoh S, Fujitani N, Sugihara H, Toda S

    Endocrinology   149 ( 10 )   4794   2008.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2008-0525

  • Expression of the extracellular region of the human interleukin-4 receptor alpha chain and interleukin-13 receptor alpha1 chain by a silkworm-baculovirus system Reviewed International journal

    Honjo E, Shoyama Y, Tamada T, Shigematsu H, Hatanaka T, Kanaji S, Arima K, Ito Y, Izuhara K, Kuroki R

    Protein Expr Purif   60 ( 1 )   25   2008.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pep.2008.03.020

  • Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease Reviewed International journal

    Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Shiraki A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K

    J Immunol   180 ( 9 )   6262   2008.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.180.9.6262

  • Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2 Reviewed International journal

    Cheli Y, Kanaji S, Jacquelin B, Chang M, Nugent DJ, Kunicki TJ

    Biochim Biophys Acta   1769 ( 9-10 )   546   2007.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbaexp.2007.06.004

  • Involvement of IL-32 in activation-induced cell death in T cells Reviewed International journal

    Goda C, Kanaji T, Kanaji S, Tanaka G, Arima K, Ohno S, Izuhara K

    Int Immunol   18 ( 2 )   233   2006.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/intimm/dxh339

  • Characterization of the interaction between interleukin-13 and interleukin-13 receptors Reviewed International journal

    Arima K, Sato K, Tanaka G, Kanaji S, Terada T, Honjo E, Kuroki R, Matsuo Y, Izuhara K

    J Biol Chem   280 ( 26 )   24915   2005.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M502571200

  • Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells Reviewed International journal

    Tanaka G, Kanaji S, Hirano A, Arima K, Shinagawa A, Goda C, Yasunaga S, Ikizawa K, Yanagihara Y, Kubo M, Kuriyama-Fujii Y, Sugita Y, Inokuchi A, Izuhara K

    Int Immunol   17 ( 6 )   797   2005.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/intimm/dxh260

  • Characterization of Inherited Differences in Transcription of the Human Integrin alpha 2 Gene Reviewed International journal

    Jacquelin B, Rozenshteyn D, Kanaji S, Koziol JA, Nurden AT, Kunicki TJ

    J Biol Chem   276 ( 26 )   23518   2001.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M102019200

  • Severe left ventricular dysfunction in a patient with primary Sjogren's syndrome Reviewed

    Takaoka (Kanaji) S, Higuchi M, Odashiro K, Yoshizawa S, Horiuchi T, Niho Y

    20 ( 3 )   199   1997.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2177/jsci.20.199

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Books

  • Application of microarray technology to bronchial asthma

    Izuhara K, Arima K, Kanaji S, Masumoto K, Kanaji T( Role: Joint author)

    John Wiley & Sons, Ltd,  2006.5 

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    Responsible for pages:Immunogenomics and Human Diseases 407-418   Language:English   Book type:Scholarly book

  • 免疫沈降法

    有馬和彦、金地佐千子、金地泰典、出原賢治( Role: Joint author)

    羊土社  2004.5 

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    Language:Japanese   Book type:Scholarly book

  • ウエスタンブロッティング法

    金地佐千子、有馬和彦、金地泰典、出原賢治( Role: Joint author)

    羊土社  2004.5 

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    Responsible for pages:すべてのバイオ研究に役立つ免疫学的プロトコール (中内啓光 編) 113-119   Language:Japanese   Book type:Scholarly book

MISC

  • Mechanistic perspectives on anti-aminoacyl-tRNA synthetase syndrome Reviewed

    10. Kanaji S, Chen W, Morodomi Y, Shapiro R, Kanaji T, Yang XL

    Trends Biochem Sci   2023.3

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1016/j.tibs.2022.09.011

  • 遺伝子検査の現状と展望 Reviewed

    出原賢治、金地佐千子、太田昭一郎、白石裕士、南雲文夫

    2008.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Involvement of cysteine protease inhibitors in the defense mechanism against parasites Reviewed

    Izuhara K, Kanaji S, Arima K, Ohta S, Shiraishi H

    2008.5

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  • Recent progress in understanding the diversity of the human ov- serpin/clade B serpin family Reviewed

    Izuhara K, Ohta S, Kanaji S, Shiraishi H, Arima K

    Cell Mol Life Sci   2008.5

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Clarification of the pathogenesis and development of clinical examination for allergic diseases Reviewed

    Izuhara K, Kanaji S, Ohta S, Arima K

    Rinsho Byori   2007.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-13 and its signal pathway: promising targets in the development of a therapeutic agent for bronchial asthma Reviewed

    Izuhara K, Arima K, Kanaji S, Kanaji T, Ohta S

    Curr Signal Transduction Therapy   2007.5

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-13: a promising therapeutic target for bronchial asth Reviewed

    Izuhara K, Arima K, Kanaji S, Ohta S, Kanaji T

    Curr Med Chem   2006.5

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-4 and IL-13: Their pathological roles in allergic diseases and their potential in developing new therapies - Update Reviewed

    Izuhara K, Arima K, Masumoto K, Kanaji S, Kanaji T

    Med Chem. Rev   2005.5

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-4/IL-13のダイオキシン類感受性への影響 Reviewed

    金地佐千子、田中剛、出原賢治

    臨床免疫   2005.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-4/IL-13と気管支喘息 Reviewed

    金地佐千子、出原賢治

    喘息   2004.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Professional Memberships

  • 日本輸血・細胞治療学会

  • 日本血液学会

  • 日本血栓止血学会

  • 日本臨床検査医学会

  • International Society on Thrombosis and Haemostasis

  • American Society of Hematology

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Research Projects

  • ヒト化VWF-GPIbαマウスを用いた血栓形成機序の解明と新規抗血小板薬の開発

    Grant number:22K21368  2024 - 2026

    日本学術振興会  科学研究費助成事業  帰国発展研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • アレルギー疾患の病態形成に関与する新規エフェクター分子の機能解析

    Grant number:20591188  2008 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • TLR4シグナルを介した気管支喘息抑制における分子機構の解析

    Grant number:19591171  2007 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • ダイオキシンのアレルギー疾患発症への影響

    Grant number:19790687  2007 - 2008

    科学研究費助成事業  若手研究(A,B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • トロンボポイエチンによるGPVI遺伝子の脱メチル化とGPVI発現誘導機序の解析

    Grant number:17790649  2005 - 2006

    科学研究費助成事業  若手研究(A,B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • インターロイキン-13を標的としたアレルギー疾患治療戦略の開発

    Grant number:16790555  2004 - 2005

    科学研究費助成事業  若手研究(A,B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • IL‐4,IL‐13のシグナル伝達機構解析に基づくアレルギー疾患発症機序の解明

    Grant number:15591058  2003 - 2004

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

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Travel Abroad

  • 2013.9 - 2024.3

    Staying countory name 1:United States   Staying institution name 1:The Scripps Research Institute

  • 2008.9 - 2013.9

    Staying countory name 1:United States   Staying institution name 1:Blood Center of Wisconsin (Versiti Blood Research Institute)

  • 2001.1 - 2003.3

    Staying countory name 1:United States   Staying institution name 1:The Scripps Research Institute