九州大学医学部附属病院   

1996.5 - 1997.5

Detection of anti-GPIbα autoantibodies in a case of immune thrombocytopenia following COVID-19 vaccination Reviewed International journal

Nakamura T, Morodomi Y, Kanaji S, Okamura T, Nagafuji K, Kanaji T

Thromb Res   209   80   2022.1

Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia Reviewed International journal

Sun J, Uchiyama S, Olson J, Morodomi Y, Cornax I, Ando N, Kohno Y, Kyaw MMT, Aguilar B, Haste NM, Kanaji S, Kanaji T, Rose WE, Sakoulas G, Marth JD, Nizet V

Sci Transl Med   13 ( 586 )   eabd6737   2021.3

Mechanisms of anti-GPIbalpha antibody-induced thrombocytopenia in mice Reviewed International journal

Morodomi Y, Kanaji S, Won E, Ruggeri ZM, Kanaji T

Blood   135 ( 25 )   2292   2020.6

Extracellular tyrosyl-tRNA synthetase cleaved by plasma proteinases and stored in platelet alpha-granules: Potential role in monocyte activation Reviewed International journal

Won E, Morodomi Y, Kanaji S, Shapiro R, Vo MN, Orje JN, Thornburg CD, Yang XL, Ruggeri ZM, Schimmel P, Kanaji T

Res Pract Thromb Haemost   4 ( 7 )   1167   2020.9

von Willebrand factor variant D1472H has no effect in mice with humanized VWF-platelet interactions Reviewed International journal

Lohmeier HK, Slobodianuk TL, Kanaji S, Haberichter SL, Montgomery RR, Flood VH

Blood Adv   4 ( 17 )   4065   2020.9

Modified application of Kawamoto's film method for super-resolution imaging of megakaryocytes in undecalcified bone marrow Reviewed International journal

Morodomi Y, Kanaji S, Won E, Kawamoto T, Kanaji T

Res Pract Thromb Haemost   4 ( 1 )   86   2019.11

von Willebrand factor propeptide to antigen ratio identifies platelet activation and reduced von Willebrand factor survival phenotype in mice Reviewed International journal

Jacobi PM, Kanaji S, Jakab D, Gehrand AL, Johnsen JM, Haberichter SL

J Thromb Haemost   16 ( 3 )   546   2018.3

Humanized GPIbalpha-von Willebrand factor interaction in the mouse Reviewed International journal

Kanaji S, Orje JN, Kanaji T, Kamikubo Y, Morodomi Y, Chen Y, Zarpellon A, Eberhardt J, Forli S, Fahs SA, Sood R, Haberichter SL, Montgomery RR, Ruggeri ZM

Blood Adv   2 ( 19 )   2522   2018.10

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia Reviewed International journal

Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha A, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P

Proc Natl Acad Sci U S A   115 ( 35 )   E8228   2018.8

Non-myeloablative conditioning with busulfan before hematopoietic stem cell transplantation leads to phenotypic correction of murine Bernard- Soulier syndrome Reviewed International journal

Kanaji S, Fahs SA, Ware J, Montgomery RR, Shi Q

J Thromb Haemost   12 ( 10 )   1726   2014.10

Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia Reviewed International journal

Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ

Blood   122 ( 15 )   2732   2013.10

Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis Reviewed International journal

Kanaji S, Fahs SA, Shi Q, Haberichter SL, Montgomery RR

J Thromb Haemost   10 ( 8 )   1646   2012.8

Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy Reviewed International journal

Kanaji S, Kuether EL, Fahs SA, Schroeder JA, Ware J, Montgomery RR, Shi Q

Mol Ther   20 ( 3 )   625   2012.3

Identification of four novel mutations in F5 associated with congenital factor V deficiency Reviewed International journal

Kanaji S, Kanaji T, Honda M, Nakazato S, Wakayama K, Tabata Y, Shibata S, Gondo H, Nakamura I, Node K, Miura M, Miyahara M, Okamura T, Nagumo F, Ohta S, Izuhara K

Int J Hematol   89 ( 1 )   71   2009.1

Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiven Reviewed International journal

Ito T, Suzuki S, Kanaji S, Shiraishi H, Ohta S, Arima K, Tanaka G, Tamada T, Honjo E, Garcia KC, Kuroki R, Izuhara K

J Biol Chem 284   284 ( 36 )   24289   2009.9

A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells Reviewed International journal

Sonoda E, Aoki S, Uchihashi K, Soejima H, Kanaji S, Izuhara K, Satoh S, Fujitani N, Sugihara H, Toda S

Endocrinology   149 ( 10 )   4794   2008.10

Characterization of a patient with atypical amegakaryocytic thrombocytopenia Reviewed International journal

Kanaji S, Kanaji T, Migita M, Kunishima S, Kunicki TJ, Okamura T, Izuhara K

Eur J Haematol   80 ( 4 )   361   2008.4

Expression of the extracellular region of the human interleukin-4 receptor alpha chain and interleukin-13 receptor alpha1 chain by a silkworm-baculovirus system Reviewed International journal

Honjo E, Shoyama Y, Tamada T, Shigematsu H, Hatanaka T, Kanaji S, Arima K, Ito Y, Izuhara K, Kuroki R

Protein Expr Purif   60 ( 1 )   25   2008.7

Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease Reviewed International journal

Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Shiraki A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K

J Immunol   180 ( 9 )   6262   2008.5

Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases Reviewed International journal

Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K

FEBS Lett   581 ( 22 )   4260   2007.9

Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2 Reviewed International journal

Cheli Y, Kanaji S, Jacquelin B, Chang M, Nugent DJ, Kunicki TJ

Biochim Biophys Acta   1769 ( 9-10 )   546   2007.9

Involvement of IL-32 in activation-induced cell death in T cells Reviewed International journal

Goda C, Kanaji T, Kanaji S, Tanaka G, Arima K, Ohno S, Izuhara K

Int Immunol   18 ( 2 )   233   2006.2

Characterization of the interaction between interleukin-13 and interleukin-13 receptors Reviewed International journal

Arima K, Sato K, Tanaka G, Kanaji S, Terada T, Honjo E, Kuroki R, Matsuo Y, Izuhara K

J Biol Chem   280 ( 26 )   24915   2005.7

Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation Reviewed International journal

Kanaji S, Kanaji T, Jacquelin B, Chang M, Nugent DJ, Komatsu N, Moroi M, Izuhara K, Kunicki TJ

Blood   105 ( 10 )   3888   2005.5

Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells Reviewed International journal

Tanaka G, Kanaji S, Hirano A, Arima K, Shinagawa A, Goda C, Yasunaga S, Ikizawa K, Yanagihara Y, Kubo M, Kuriyama-Fujii Y, Sugita Y, Inokuchi A, Izuhara K

Int Immunol   17 ( 6 )   797   2005.6

Convulxin binds to native, human glycoprotein Ib alpha Reviewed International journal

Kanaji S, Kanaji T, Furihata K, Kato K, Ware JL, Kunicki TJ

J Biol Chem   278 ( 41 )   39452   2003.10

The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion Reviewed International journal

Kato K, Kanaji T, Russell S, Kunicki TJ, Furihata K, Kanaji S, Marchese P, Reininger A, Ruggeri ZM, Ware J

Blood   102 ( 5 )   1701   2003.9

Identification and characterization of two novel mutations (Q421 K and R123P) in congenital factor XII deficiency Reviewed International journal

Kanaji T, Kanaji S, Osaki K, Kuroiwa M, Sakaguchi M, Mihara K, Niho Y, Okamura T

Thromb Haemost   86 ( 6 )   1409   2001.12

Characterization of Inherited Differences in Transcription of the Human Integrin alpha 2 Gene Reviewed International journal

Jacquelin B, Rozenshteyn D, Kanaji S, Koziol JA, Nurden AT, Kunicki TJ

J Biol Chem   276 ( 26 )   23518   2001.6

Characterization of the signal that directs Tom20 to the mitochondrial outer membrane Reviewed International journal

Kanaji S, Iwahashi J, Kida Y, Sakaguchi M, Mihara K

J Cell Biol   151 ( 2 )   277   2000.10

Hemophagocytic syndrome associated with fulminant ulcerative colitis and presumed acute pancreatitis Reviewed International journal

Kanaji S, Okuma K, Tokumitsu Y, Yoshizawa S, Nakamura M, Niho Y

Am J Gastroenterol   93 ( 10 )   1956   1998.10

Severe left ventricular dysfunction in a patient with primary Sjogren's syndrome Reviewed

Takaoka (Kanaji) S, Higuchi M, Odashiro K, Yoshizawa S, Horiuchi T, Niho Y

日本臨床免疫学会会誌   20 ( 3 )   199   1997.6

High-sensitivity thrombin generation profiling identifies divergent coagulation states across peripheral artery disease severity Reviewed

Morodomi Y, Yoshino S, Morisaki K, Kamikubo Y, Inoue R, Fujioka Y, Inoue K, Kanaji S, Kanaji T, Ishimoto K, Zheng S, Kizaki S, Yasuda-Yoshihara N, Harada Y, Yoshizumi T, Yonemitsu Y

Thrombosis Update   22   100235   2026.3

Primary myelofibrosis with Factor V Leiden diagnosed following portal vein thrombosis Reviewed

沼田 晃彦, 島 隆宏, 次郎丸 高志, 金地 佐千子, 加藤 光次, 赤司 浩一

臨床血液   67 ( 2 )   104 - 108   2026.2

Mechanistic perspectives on anti-aminoacyl-tRNA synthetase syndrome Invited Reviewed

Kanaji S, Chen W, Morodomi Y, Shapiro R, Kanaji T, Yang XL

Trends Biochem Sci.   48 ( 3 )   288 - 302   2023.3

A Case of Renal Cyst Infection Developing Fulminant Drug-Induced Immune Thrombocytopenic Purpura During Multiple Antibiotic Therapy International conference

Kanako Iwamura, Yuta Matsukuma, Narumichi Iwamura, Teppei Sakota, Sachiko Kanaji, Shunsuke Yamada, Toshiaki Nakano, Tetsuro Ago

World Congress of Nephrology 2026 

次世代シーケンサーを用いた先天性プロテインS欠乏症の遺伝子解析とプロテインS比活性の有用性検証

西田　碧、上田沙央理、松本信也、藤島章義、植栁泰、相原正宗、 瀬戸山大樹、金地佐千子、仙波雄一郎、酒田あゆみ、 國崎祐哉

第37回 日本臨床化学会 九州支部総会  2026.2 

von Willebrand病の診断効率向上への取り組み(Mutational Profiles and Multimer Analysis for Subtyping Patients with von Willebrand Disease: Preliminary Results from a Newly Initiated Study)

Ohga Shinya, Ishimura Masataka, Zhang Yang, Matsumoto Nobuya, Fujishima Akiyoshi, Ueyanagi Yasushi, Yada Yutaro, Sonoda Motoshi, Eguchi Katsuhide, Sakata Ayumi, Kunisaki Yuya, Kanaji Sachiko

日本小児血液・がん学会雑誌  2025.12  (一社)日本小児血液・がん学会

次世代シーケンサーを用いた先天性プロテインS欠乏症の遺伝子解析と プロテインS比活性の有用性検証

西田碧、上田沙央理、松本信也、藤島章義、植栁泰、相原正宗、瀬戸山大樹、金地佐千子、仙波雄一郎、酒田あゆみ、國崎祐哉

第65回日本臨床化学会年次学術集 

Type 2B von Willebrand病診断におけるフローサイトメトリー解析の有用性の検討

張 洋, 島 隆宏, 石村 匡崇, 松本 信也, 藤島 章義, 植柳 泰, 上田 沙央理, 西田 碧, 大賀 慎也, 山中 育未, 瀬戸山 大樹, 加藤 光次, 赤司 浩一, 酒田 あゆみ, 國崎 祐哉, 金地 佐千子

日本血液学会学術集会  2025.10  (一社)日本血液学会

健常人と血栓症患者の遺伝子解析により明らかとなったプロテインS遺伝子変異と血栓症発症リスクの相関

上田 沙央理, 西田 碧, 松本 信也, 藤島 章義, 植柳 泰, 相原 正宗, 金地 佐千子, 瀬戸山 大樹, 仙波 雄一郎, 酒田 あゆみ, 國崎 祐哉

日本血液学会学術集会  2025.10  (一社)日本血液学会

Biogenesis of 5"-tRNA His halves International coauthorship International conference

T. Kanaji, S. Kanaji, R. Shapiro, M. Horii, P. Schimmel, X. Yang

FEBS Special Meeting “Expanding frontiers in aminoacyl-tRNA synthetase research“ 

LC-MS/MSを用いたDOAC吸着処理の有効性評価と凝固制御因子活性検査への影響評価

向窪 七海, 植柳 泰, 船崎 希, 門司 宜久, 渡邊 久美子, 諸熊 由子, 辛島 貴人, 上田 沙央理, 瀬戸山 大樹, 金地 佐千子, 松本 信也, 酒田 あゆみ, 國崎 祐哉

JSBMS Letters  2025.8  (一社)日本医用マススペクトル学会

DOACが及ぼす血栓性素因スクリーニング検査への影響とDOAC内服患者検体の吸着処理による補正効果

向窪 七海, 船崎 希, 門司 宜久, 渡邉 久美子, 諸熊 由子, 辛島 貴人, 上田 沙央理, 植柳 泰, 松本 信也, 酒田 あゆみ, 金地 佐千子, 國崎 祐哉

日本臨床検査医学会誌  2025.7  (一社)日本臨床検査医学会

ミトコンドリア心筋症における遺伝子変異と病態機能解析

上田 沙央理, 松本 信也, 藤島 章義, 植柳 泰, 竹内 実芳, 瀬戸山 大樹, 金地 佐千子, 酒田 あゆみ, 國崎 祐哉

日本臨床検査医学会誌  2025.7  (一社)日本臨床検査医学会

ApoEノックアウトマウスにおける慢性炎症と炎症性血小板の解析

諸富洋介、金地佐千子、安田法子、原田結、米満吉和、金地泰典

日本血栓止血学会  2025.6  (一社)日本血栓止血学会

止血・血栓形成におけるVWF-GPIb相互作用とADAMTS13による制御 Invited

Sachiko Kanaji

日本血栓止血学会  2025.6  日本血栓止血学会

血小板無力症とvon Willebrand病合併症例の遺伝子及び病態解析

島隆宏、Zhang Yang、上田沙央理、西田碧、山中育未、諸富洋介、岡村孝、赤司浩一、國崎祐哉、金地佐千子

日本血栓止血学会  2025.6  (一社)日本血栓止血学会

ヒト型トロンビン受容体発現血小板モデルマウスの作製と解析 International coauthorship

金地 佐千子, Zarpellon Alessandro, Aiolfi Roberto, 諸富 洋介, Zampolli Antonella, Won Eric, Ruggeri Zaverio, 金地 泰典

日本血栓止血学会  2024.5  (一社)日本血栓止血学会

非脱灰骨髄組織の超解像イメージングを可能にする観察法の開発

諸富 洋介, 金地 佐千子, Won Eric, 川本 忠文, 原田 結, 米満 吉和, 金地 泰典

日本血栓止血学会  2024.5  (一社)日本血栓止血学会

Recent progress in understanding the diversity of the human ov- serpin/clade B serpin family Reviewed

Izuhara K, Ohta S, Kanaji S, Shiraishi H, Arima K

Cell Mol Life Sci   2008.5

Clarification of the pathogenesis and development of clinical examination for allergic diseases Reviewed

Izuhara K, Kanaji S, Ohta S, Arima K

Rinsho Byori   2007.5

IL-13 and its signal pathway: promising targets in the development of a therapeutic agent for bronchial asthma Reviewed

Izuhara K, Arima K, Kanaji S, Kanaji T, Ohta S

Curr Signal Transduction Therapy   2007.5

IL-13: a promising therapeutic target for bronchial asth Reviewed

Izuhara K, Arima K, Kanaji S, Ohta S, Kanaji T

Curr Med Chem   2006.5

IL-4 and IL-13: Their pathological roles in allergic diseases and their potential in developing new therapies - Update Reviewed

Izuhara K, Arima K, Masumoto K, Kanaji S, Kanaji T

Med Chem. Rev   2005.5

IL-4/IL-13のダイオキシン類感受性への影響 Reviewed

金地佐千子、田中剛、出原賢治

臨床免疫   2005.5

IL-4/IL-13と気管支喘息 Reviewed

金地佐千子、出原賢治

喘息   2004.5

日本産婦人科　新生児血液学会

2025.3 - Present

日本輸血・細胞治療学会

American Society of Hematology

日本内科学会

TLR4シグナルを介した気管支喘息抑制における分子機構の解析

Grant number：19591171  2007 - 2008

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

トロンボポイエチンによるGPVI遺伝子の脱メチル化とGPVI発現誘導機序の解析

Grant number：17790649  2005 - 2006

Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(A)or(B)

インターロイキン-13を標的としたアレルギー疾患治療戦略の開発

Grant number：16790555  2004 - 2005

Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(A)or(B)

IL‐4,IL‐13のシグナル伝達機構解析に基づくアレルギー疾患発症機序の解明

Grant number：15591058  2003 - 2004

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)