Humanized GPIbalpha-von Willebrand factor interaction in the mouse 査読 国際誌

Kanaji S, Orje JN, Kanaji T, Kamikubo Y, Morodomi Y, Chen Y, Zarpellon A, Eberhardt J, Forli S, Fahs SA, Sood R, Haberichter SL, Montgomery RR, Ruggeri ZM

Blood Adv   2 ( 19 )   2522   2018年10月

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia 査読 国際誌

Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha A, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P

Proc Natl Acad Sci U S A   115 ( 35 )   E8228   2018年8月

Non-myeloablative conditioning with busulfan before hematopoietic stem cell transplantation leads to phenotypic correction of murine Bernard- Soulier syndrome 査読 国際誌

Kanaji S, Fahs SA, Ware J, Montgomery RR, Shi Q

J Thromb Haemost   12 ( 10 )   1726   2014年10月

Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia 査読 国際誌

Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ

Blood   122 ( 15 )   2732   2013年10月

Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis 査読 国際誌

Kanaji S, Fahs SA, Shi Q, Haberichter SL, Montgomery RR

J Thromb Haemost   10 ( 8 )   1646   2012年8月

Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy 査読 国際誌

Kanaji S, Kuether EL, Fahs SA, Schroeder JA, Ware J, Montgomery RR, Shi Q

Mol Ther   20 ( 3 )   625   2012年3月

Identification of four novel mutations in F5 associated with congenital factor V deficiency 査読 国際誌

Kanaji S, Kanaji T, Honda M, Nakazato S, Wakayama K, Tabata Y, Shibata S, Gondo H, Nakamura I, Node K, Miura M, Miyahara M, Okamura T, Nagumo F, Ohta S, Izuhara K

Int J Hematol   89 ( 1 )   71   2009年1月

Characterization of a patient with atypical amegakaryocytic thrombocytopenia 査読 国際誌

Kanaji S, Kanaji T, Migita M, Kunishima S, Kunicki TJ, Okamura T, Izuhara K

Eur J Haematol   80 ( 4 )   361   2008年4月

Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases 査読 国際誌

Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K

FEBS Lett   581 ( 22 )   4260   2007年9月

Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation 査読 国際誌

Kanaji S, Kanaji T, Jacquelin B, Chang M, Nugent DJ, Komatsu N, Moroi M, Izuhara K, Kunicki TJ

Blood   105 ( 10 )   3888   2005年5月

Convulxin binds to native, human glycoprotein Ib alpha 査読 国際誌

Kanaji S, Kanaji T, Furihata K, Kato K, Ware JL, Kunicki TJ

J Biol Chem   278 ( 41 )   39452   2003年10月

The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion 査読 国際誌

Kato K, Kanaji T, Russell S, Kunicki TJ, Furihata K, Kanaji S, Marchese P, Reininger A, Ruggeri ZM, Ware J

Blood   102 ( 5 )   1701   2003年9月

Identification and characterization of two novel mutations (Q421 K and R123P) in congenital factor XII deficiency 査読 国際誌

Kanaji T, Kanaji S, Osaki K, Kuroiwa M, Sakaguchi M, Mihara K, Niho Y, Okamura T

Thromb Haemost   86 ( 6 )   1409   2001年12月

Characterization of the signal that directs Tom20 to the mitochondrial outer membrane 査読 国際誌

Kanaji S, Iwahashi J, Kida Y, Sakaguchi M, Mihara K

J Cell Biol   151 ( 2 )   277   2000年10月

Hemophagocytic syndrome associated with fulminant ulcerative colitis and presumed acute pancreatitis 査読 国際誌

Kanaji S, Okuma K, Tokumitsu Y, Yoshizawa S, Nakamura M, Niho Y

Am J Gastroenterol   93 ( 10 )   1956   1998年10月

Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic "integrated stress response" 査読 国際誌

Jones JA, Wei N, Cui H, Shi Y, Fu G, Rauniyar N, Shapiro R, Morodomi Y, Berenst N, Dumitru CD, Kanaji S, Yates JR, 3rd, Kanaji T, Yang XL

Cell Rep   42 ( 6 )   112632   2023年6月

Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia 査読 国際誌

Sun J, Uchiyama S, Olson J, Morodomi Y, Cornax I, Ando N, Kohno Y, Kyaw MMT, Aguilar B, Haste NM, Kanaji S, Kanaji T, Rose WE, Sakoulas G, Marth JD, Nizet V

Sci Transl Med   13 ( 586 )   eabd6737   2021年3月

Extracellular tyrosyl-tRNA synthetase cleaved by plasma proteinases and stored in platelet alpha-granules: Potential role in monocyte activation 査読 国際誌

Won E, Morodomi Y, Kanaji S, Shapiro R, Vo MN, Orje JN, Thornburg CD, Yang XL, Ruggeri ZM, Schimmel P, Kanaji T

Res Pract Thromb Haemost   4 ( 7 )   1167   2020年9月

von Willebrand factor variant D1472H has no effect in mice with humanized VWF-platelet interactions 査読 国際誌

Lohmeier HK, Slobodianuk TL, Kanaji S, Haberichter SL, Montgomery RR, Flood VH

Blood Adv   4 ( 17 )   4065   2020年9月

Modified application of Kawamoto's film method for super-resolution imaging of megakaryocytes in undecalcified bone marrow 査読 国際誌

Morodomi Y, Kanaji S, Won E, Kawamoto T, Kanaji T

Res Pract Thromb Haemost   4 ( 1 )   86   2019年11月

von Willebrand factor propeptide to antigen ratio identifies platelet activation and reduced von Willebrand factor survival phenotype in mice 査読 国際誌

Jacobi PM, Kanaji S, Jakab D, Gehrand AL, Johnsen JM, Haberichter SL

J Thromb Haemost   16 ( 3 )   546   2018年3月

Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiven 査読 国際誌

Ito T, Suzuki S, Kanaji S, Shiraishi H, Ohta S, Arima K, Tanaka G, Tamada T, Honjo E, Garcia KC, Kuroki R, Izuhara K

J Biol Chem 284   284 ( 36 )   24289   2009年9月

A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells 査読 国際誌

Sonoda E, Aoki S, Uchihashi K, Soejima H, Kanaji S, Izuhara K, Satoh S, Fujitani N, Sugihara H, Toda S

Endocrinology   149 ( 10 )   4794   2008年10月

Expression of the extracellular region of the human interleukin-4 receptor alpha chain and interleukin-13 receptor alpha1 chain by a silkworm-baculovirus system 査読 国際誌

Honjo E, Shoyama Y, Tamada T, Shigematsu H, Hatanaka T, Kanaji S, Arima K, Ito Y, Izuhara K, Kuroki R

Protein Expr Purif   60 ( 1 )   25   2008年7月

Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease 査読 国際誌

Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Shiraki A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K

J Immunol   180 ( 9 )   6262   2008年5月

Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2 査読 国際誌

Cheli Y, Kanaji S, Jacquelin B, Chang M, Nugent DJ, Kunicki TJ

Biochim Biophys Acta   1769 ( 9-10 )   546   2007年9月

Involvement of IL-32 in activation-induced cell death in T cells 査読 国際誌

Goda C, Kanaji T, Kanaji S, Tanaka G, Arima K, Ohno S, Izuhara K

Int Immunol   18 ( 2 )   233   2006年2月

Characterization of the interaction between interleukin-13 and interleukin-13 receptors 査読 国際誌

Arima K, Sato K, Tanaka G, Kanaji S, Terada T, Honjo E, Kuroki R, Matsuo Y, Izuhara K

J Biol Chem   280 ( 26 )   24915   2005年7月

Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells 査読 国際誌

Tanaka G, Kanaji S, Hirano A, Arima K, Shinagawa A, Goda C, Yasunaga S, Ikizawa K, Yanagihara Y, Kubo M, Kuriyama-Fujii Y, Sugita Y, Inokuchi A, Izuhara K

Int Immunol   17 ( 6 )   797   2005年6月

Characterization of Inherited Differences in Transcription of the Human Integrin alpha 2 Gene 査読 国際誌

Jacquelin B, Rozenshteyn D, Kanaji S, Koziol JA, Nurden AT, Kunicki TJ

J Biol Chem   276 ( 26 )   23518   2001年6月

Severe left ventricular dysfunction in a patient with primary Sjogren's syndrome 査読

Takaoka (Kanaji) S, Higuchi M, Odashiro K, Yoshizawa S, Horiuchi T, Niho Y

20 ( 3 )   199   1997年6月

IL-13 and its signal pathway: promising targets in the development of a therapeutic agent for bronchial asthma 査読

Izuhara K, Arima K, Kanaji S, Kanaji T, Ohta S

Curr Signal Transduction Therapy   2007年5月

IL-13: a promising therapeutic target for bronchial asth 査読

Izuhara K, Arima K, Kanaji S, Ohta S, Kanaji T

Curr Med Chem   2006年5月

IL-4 and IL-13: Their pathological roles in allergic diseases and their potential in developing new therapies - Update 査読

Izuhara K, Arima K, Masumoto K, Kanaji S, Kanaji T

Med Chem. Rev   2005年5月

IL-4/IL-13のダイオキシン類感受性への影響 査読

金地佐千子、田中剛、出原賢治

臨床免疫   2005年5月

IL-4/IL-13と気管支喘息 査読

金地佐千子、出原賢治

喘息   2004年5月

アメリカ血液学会

インターロイキン-13を標的としたアレルギー疾患治療戦略の開発

研究課題/領域番号：16790555  2004年 - 2005年

科学研究費助成事業  若手研究(A,B)

IL‐4,IL‐13のシグナル伝達機構解析に基づくアレルギー疾患発症機序の解明

研究課題/領域番号：15591058  2003年 - 2004年

日本学術振興会  科学研究費助成事業  基盤研究(C)