Updated on 2024/10/01

Information

 

写真a

 
AKAHOSHI TOMOHIKO
 
Organization
Faculty of Medical Sciences Department of Advanced Medical Initiatives Professor
Kyushu University Hospital Liver Surgery(Joint Appointment)
Kyushu University Hospital Intensive Care Unit(Joint Appointment)
Kyushu University Hospital Department of Advanced Medicine and Innovative Technology(Joint Appointment)
School of Medicine Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medical Sciences(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426222
Profile
EDUCATION Degrees/ Diplomas/ Licensures and Certifications 2002 Ph.D. Kyushu University, Graduate School 1995 M.D. Kyushu University PROFESSIONAL TRAINING and EMPLOYMENT Present Academic Appointment 2014~now Associate Professor (Chief of section) Graduate School of Medical Sciences, Disaster and Emergency medicine, Kyushu University, Fukuoka, Japan 2014~now Vice President Emergency and Critical care center, Kyushu university hospital  PROFESSIONAL AFFILIATIONS AND ACTIVITIES Japanese Surgical Society Japanese Association for Acute Medicine The Japanese Society of Gastroenterological Surgery Japanese Society of endoscopic surgery Japanese Society of portal hypertension Japan Society of Hepatology Japanese trauma operative management course instructor  BOARD CERTIFICATION Board Certified SurgeonBoard Certified Gastroenterological Surgeon Board Certified Emergency and critical care medicine Board Certified Hepatologist of Japan Society of Hepatology Board Certified Digestive endoscopy Board Certified American Trauma Operative Management course

Degree

  • Doctor of phylosophy

Research Interests・Research Keywords

  • Research theme:development for new treatment for ARDS

    Keyword:ARDS

    Research period: 2021.10

  • Research theme:The efficacy of Adipose tissue derived stem cell on liver failure or liver cirrhosis

    Keyword:liver failure

    Research period: 2010.4 - 2012.12

  • Research theme:The effective training for acute care surgery

    Keyword:acute care surgery

    Research period: 2010.4 - 2011.12

  • Research theme:Portal hypertension Abnormal microcirculation in cirrhotic liver Hypersplenism

    Keyword:Liver cirrhosis, Portal hypertension, splenomegaly

    Research period: 2008.4 - 2008.12

Awards

  • 福岡医学会賞

    2017.1   ふくおか医療財団  

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    ICUにおけるサルコペニアの意義に関する研究

  • 第38回かなえ医薬振興財団研究助成

    2009.11   財団法人 かなえ医薬振興財団  

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    肝硬変症における肝線維化の分子メカニズム解明と脾臓内免疫細胞制御による新しい治療法の開発

Papers

  • Sarcopenia is a predictive factor for prolonged intensive care unit stays in high-energy blunt trauma patients Reviewed International journal

    Akahoshi T

    Acute Medicine & Surgery   2016.8

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  • 皮下脂肪組織由来間葉系幹細胞を用いた肝硬変に対する新しい治療法の確立のための 実験的検討 Invited Reviewed International journal

    赤星 朋比古, 橋爪 誠

    4 ( 4 )   145 - 147   2016.7

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    Language:Japanese  

  • Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients. Reviewed International journal

    Kinjo N, Kawanaka H, Akahoshi T, Maehara Y

    Hepatol Res   43 ( 9 )   933 - 941   2013.9

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    Language:English  

    DOI: 10.1111/hepr.12040

  • Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C Reviewed International journal

    Sumida K, Shimoda S, Iwasaka S, Hisamoto S, Kawanaka H, AKahoshi T, Ikegami T, Akashi K

    Clin Exp Immunol   174 ( 1 )   172 - 178   2013.8

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    Language:English  

    DOI: 10.1111/cei.

  • Merits of prophylactic sclerotherapy for esophageal varices concomitant unresectable hepatocellular carcinoma: Prospective randomized study. Reviewed International journal

    Akahoshi T

    Dig Endosc.   2013.5

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    DOI: 10.1111/den.12119

  • Image-guided laparoscopic surgery in an open MRI operating theater. Reviewed International journal

    Tsutsumi N, Tomikawa M, Uemura M, Akahoshi T

    Surg Endosc.   27 ( 6 )   2178 - 2184   2013.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 1007/s00464-012-2737

  • Impact of ballon-occluded retrograde transvenous obliteration on management of isolated fundal gastric varicual bleeding

    Tomohiko Akahoshi, MORIMASA TOMIKAWA, Norifumi Tsutsumi, Makoto Hashizume, Yoshihiko Maehara

    Hepatol Res.   2012 Apr;42 ( 4 )   385 - 393   2012.4

  • Laparoscopic splenectomy with peginterferon and ribavirin therapy for patients with hepatitis C virus cirrhosis and hypersplenism Reviewed International journal

    AKAHOSHI T

    Surg Endosc.   24   680 - 685   2010.8

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    Laparoscopic splenectomy with peginterferon and ribavirin therapy for patients with hepatitis C virus cirrhosis and hypersplenism.

  • Neuroendocrine carcinoma in liver , a case report and literature review. Surgery Today Surg Today. Reviewed International journal

    Akahoshi T, Higashi H, Takeuchi H, Muto Y.

    Surg Today.   2010.1

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  • Selective cyclooxygenase(COX)inhibition causes damage to portal hypertensive gastric mucosa Role of nitric oxide and NF-kapperB Reviewed International journal

    Tomohiko Akahoshi

    The FASEB Journal   19 ( 9 )   1163 - 1165   2005.7

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  • Role of the spleen in liver fibrosis in rats may be mediated by transforming growth factor beta-1. International journal

    Tomohiko Akahoshi

    Journal of Gastroenterlogy and Hepatology   17 ( 1 )   59 - 65   2002.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1440-1746.2002.02667.x

  • Long-term results of endoscopic Histoacryl injection sclerotherapy for gastric variceal bleeding: a 10-year experience. International journal

    Akahoshi T

    Surgery   131 ( 1 )   S176 - S181   2002.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1067/msy.2002.119501

  • Practice guidelines on endoscopic surgery for qualified surgeons by the Endoscopic Surgical Skill Qualification System: Pancreas

    Nakata, K; Ohtsuka, T; Nagakawa, Y; Nakamura, Y; Misawa, T; Nagao, Y; Akahoshi, T; Hashizume, M; Nakamura, M

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   17 ( 4 )   e13370   2024.10   ISSN:1758-5902 eISSN:1758-5910

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    Language:English   Publisher:Asian Journal of Endoscopic Surgery  

    DOI: 10.1111/ases.13370

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  • Impact of sympathetic hyperactivity induced by brain microglial activation on organ damage in sepsis with chronic kidney disease

    Nishihara, M; Shinohara, K; Ikeda, S; Akahoshi, T; Tsutsui, H

    JOURNAL OF INTENSIVE CARE   12 ( 1 )   31   2024.9   ISSN:2052-0492

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    Language:English   Publisher:Journal of Intensive Care  

    Background: Sympathetic nerve activity (SNA) plays a central role in the pathogenesis of several diseases such as sepsis and chronic kidney disease (CKD). Activation of microglia in the paraventricular nucleus of the hypothalamus (PVN) has been implicated in SNA. The mechanisms responsible for the adverse prognosis observed in sepsis associated with CKD remain to be determined. Therefore, we aimed to clarify the impact of increased SNA resulting from microglial activation on hemodynamics and organ damage in sepsis associated with CKD. Methods and results: In protocol 1, male Sprague–Dawley rats underwent either nephrectomy (Nx) or sham surgery followed by cecal ligation and puncture (CLP) or sham surgery. After CLP, Nx-CLP rats exhibited decreased blood pressure, increased heart rate, elevated serum creatinine and bilirubin levels, and decreased platelet count compared to Nx-Sham rats. Heart rate variability analysis revealed an increased low to high frequency (LF/HF) ratio in Nx-CLP rats, indicating increased SNA. Nx-CLP rats also had higher creatinine and bilirubin levels and lower platelet counts than sham-CLP rats after CLP. In protocol 2, Nx-CLP rats were divided into two subgroups: one received minocycline, an inhibitor of microglial activation, while the other received artificial cerebrospinal fluid (CSF) intracerebroventricularly via an osmotic minipump. The minocycline-treated group (Nx-mino-CLP) showed attenuated hypotensive and increased heart rate responses compared to the CSF-treated group (Nx-CSF-CLP), and the LF/HF ratio was also decreased. Echocardiography showed larger left ventricular dimensions and inferior vena cava in the Nx-mino-CLP group. In addition, creatinine and bilirubin levels were lower and platelet counts were higher in the Nx-mino-CLP group compared to the Nx-CSF-CLP group. Conclusions: In septic rats with concomitant CKD, SNA was significantly enhanced and organ dysfunction was increased. It has been suggested that the mechanism of exacerbated organ dysfunction in these models may involve abnormal systemic hemodynamics, possibly triggered by activation of the central sympathetic nervous system through activation of microglia in the PVN.

    DOI: 10.1186/s40560-024-00742-2

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  • ICU rehabilitation and outcomes in elderly pelvic ring fractures due to high-energy trauma

    Momii Kenta, Yagi Hiroki, Nezu Tomoyuki, Ohsaki Kanji, Man Chen, Tajimi Takahiro, Iyonaga Takeshi, Nishihara Masaaki, Shono Yuji, Maki Jun, Akahoshi Tomohiko, Nakashima Yasuharu

    The Journal of Physical Fitness and Sports Medicine   13 ( 4 )   131 - 137   2024.7   ISSN:21868131 eISSN:21868123

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    Language:English   Publisher:The Japanese Society of Physical Fitness and Sports Medicine  

    <p>Pelvic fractures, accounting for 2–8% of skeletal injuries, present a significant burden in patients with trauma. High-energy incidents often result in severe pelvic trauma accompanied by comorbidities leading to high mortality rates. Managing these complications adds complexity to the treatment process, particularly in older patients who experience longer recovery times and higher injury severity. To improve the long-term quality of life, a multidisciplinary approach is essential. However, rehabilitation feasibility is influenced by the patient’s condition and pelvic fixation stability, necessitating individualized treatment. This study investigated the rehabilitation status and long-term outcomes of older patients with severe polytrauma and pelvic ring fractures caused by high-energy trauma. The results revealed that 79.2% of the patients achieved full weight-bearing, with a median time of 41.5 days, and eventually 58.3% were discharged home. Complications were observed in 83.3% of the patients, with various challenges affecting successful home discharge. Multidisciplinary rehabilitation programs are promising for optimizing outcomes and facilitating recovery in vulnerable patient populations. Still, larger, more focused studies are needed to gain more comprehensive insights into the treatment and recovery of older patients with pelvic ring fractures and severe polytrauma. Understanding these factors is crucial for guiding clinical decision-making and improving long-term outcomes in this population.</p>

    DOI: 10.7600/jpfsm.13.131

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  • Skeletal Muscle Mass Assessment in Pediatric Patients: Development of a Normative Equation and Assessment of Factors Associated With a Low Skeletal Muscle Mass in PICU Patients

    Matsuoka, W; Mizuguchi, S; Kaku, N; Higashi, K; Tetsuhara, K; Akahoshi, T; Ohga, S

    PEDIATRIC CRITICAL CARE MEDICINE   25 ( 7 )   621 - 628   2024.7   ISSN:1529-7535 eISSN:1947-3893

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    Language:English   Publisher:Pediatric Critical Care Medicine  

    OBJECTIVES: To develop an equation for defining a low skeletal muscle mass (SMM) in children and to investigate risk factors and outcomes associated with low SMM in critically ill pediatric patients. DESIGN: Single-center retrospective pediatric cohorts, 2011-2018. SETTING: Tertiary Emergency and Critical Care Center of Kyushu University Hospital in Japan. PATIENTS: We studied two cohorts of pediatric patients 1-15 years old who underwent abdominal CT at the level of the third lumbar vertebra (L3). First a cohort of trauma patients presented to the emergency department in whom we developed an SMM regression equation. Second, a cohort of patients who had undergone abdominal CT within 3 days of PICU admission. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The equation for estimating normal SMM used sex, age, and weight. Low SMM was defined as less than 80% of normal. In the 112 patients in the PICU cohort, median (range) age was 68 (13-191) months, and 83 (74.1%) had underlying disease. There was low SMM in 54 patients (48.2%). Regarding associations, using odds ratio (OR) and 95% CI, we found that low dietary intake (OR 4.33 [95% CI, 1.37-13.70]; p = 0.013) and the presence of underlying disease (OR 7.44 [95% CI, 2.10-26.30]; p = 0.002) were independently associated with greater odds of low SMM. Low SMM, compared with normal SMM, was also associated with longer hospital stays (42.5 d vs. 20.5 d; p = 0.007; β, 1.59; 95% CI, 1.09-2.33; p = 0.016). CONCLUSIONS: In this retrospective PICU cohort from a single center in Japan, we found that low SMM at PICU admission was present in almost half the cases. Low SMM, as defined by being less than 80% of the normal, was associated with greater odds of low dietary intake and underlying chronic disease. Furthermore, low SMM was associated with longer hospital stays.

    DOI: 10.1097/PCC.0000000000003511

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  • Changes of histidine-rich glycoprotein levels in critically ill septic patients. International journal

    Ayu Nabila Kusuma Pradana, Tomohiko Akahoshi, Jie Guo, Yukie Mizuta, Shuntaro Matsunaga, Sayoko Narahara, Masaharu Murata, Ken Yamaura

    Shock (Augusta, Ga.)   62 ( 3 )   351 - 356   2024.6   ISSN:1073-2322 eISSN:1540-0514

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    BACKGROUND: Histidine-rich glycoprotein (HRG), a potential prognostic factor in sepsis, lacks clarity regarding its relevance in septic-induced shock, disseminated intravascular coagulation (DIC), and acute respiratory distress syndrome (ARDS) pathogenesis. This study investigated the association between HRG concentrations and these critical conditions. METHODS: Blood samples were collected from 53 critically ill patients on days 1, 3, 5, and 7 after ICU admission at the Kyushu University Hospital. Daily clinical and laboratory data were recorded, and patient survival was assessed 28 days after ICU admission. RESULTS: Serum HRG concentrations were significantly reduced on days 3, 5, and 7 in patients with septic shock and DIC but not in those with ARDS. While initial HRG levels on day one were not correlated with survival, non-survivors displayed decreased HRG levels, notably on days 3, 5, and 7 post-ICU admissions. The HRG levels remained stable in survivors. A progressive decrease was associated with higher mortality rates, particularly on days 5 and 7. On day 5, an HRG level with a cutoff of 25.5 μg/mL showed a sensitivity of 0.77 and a specificity of 0.75, indicating significantly lower survival rates (log-rank test, P < 0.05). CONCLUSION: HRG presents a potential intervention for critically ill sepsis patients, providing a novel strategy to enhance outcomes. Further research is needed to explore the therapeutic potential of HRG in sepsis management.

    DOI: 10.1097/SHK.0000000000002406

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  • 臨牀指針 マムシ咬傷により急性腎不全・腸管壊死に陥り死亡した1例

    高森 信乃介, 赤星 朋比古, 高橋 慶多, 籾井 健太, 彌永 武史, 西原 正章, 大澤 さやか, 生野 雄二, 牧 盾, 徳田 賢太郎, 山浦 健

    臨牀と研究   101 ( 6 )   735 - 738   2024.6   ISSN:0021-4965

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    Language:Japanese   Publisher:大道学館出版部  

  • 特集 門脈血行異常に対する治療up to date Budd-Chiari症候群

    赤星 朋比古

    小児外科   56 ( 5 )   425 - 428   2024.5   ISSN:03856313

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    Publisher:東京医学社  

    DOI: 10.24479/ps.0000000805

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  • Early-stage modeling and analysis of continuum compliant structure for multi-DOF endoluminal forceps using pseudo-rigid-body model

    Keisuke Osawa, D. S. V. Bandara, Ryu Nakadate, Eiichiro Tanaka, Yoshihiro Nagao, Tomohiko Akahoshi, Masatoshi Eto, Jumpei Arata

    Advanced Robotics   37 ( 23 )   1485 - 1494   2023.12   ISSN:0169-1864 eISSN:1568-5535

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    Publishing type:Research paper (scientific journal)   Publisher:Informa UK Limited  

    DOI: 10.1080/01691864.2023.2291137

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  • 特集 早わかり消化器内視鏡関連ガイドライン2023 Ⅵ.消化器全般におよぶもの 門脈血行異常症ガイドライン

    古市 好宏, 鹿毛 政義, 小原 勝敏, 大藤 さとこ, 赤星 朋比古, 日高 央, 太田 正之, 吉田 寛, 橋爪 誠, 田中 篤

    消化器内視鏡   35 ( 9 )   1295 - 1302   2023.9   ISSN:09153217

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    Publisher:東京医学社  

    DOI: 10.24479/endo.0000000894

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  • Emphysematous pyelonephritis with ST elevation accompanied by reciprocal changes mimicking acute coronary syndrome. International journal

    Kiwamu Hatakeyama, Yuji Shono, Takuma Hashimoto, Taiki Sakamoto, Masaaki Nishihara, Takeshi Iyonaga, Soichi Mizuguchi, Takafumi Sakamoto, Jun Maki, Tomohiko Akahoshi

    The American journal of emergency medicine   70   208.e5-208.e7   2023.8

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    Patients with infectious diseases including sepsis can develop ST segment changes on an electrocardiogram (ECG) in the absence of coronary artery disease. However, ST elevation with "reciprocal ST segment depression (RSTD)", which is recognized as a specific finding for ST-elevated myocardial infarction, is rare in such patients. Although a small number of cases have reported ST-segment elevation in gastritis, cholecystitis, and sepsis, regardless of coronary artery disease, none presented with reciprocal changes. Here, we describe a rare case of a patient with emphysematous pyelonephritis complicating septic shock who developed ST elevation accompanied by reciprocal changes with no coronary occlusion. Emergency physicians should consider the possibility of acute coronary syndrome mimicking, and choose non-invasive diagnostic procedures when investigating the causes of ECG abnormalities associated with critically ill patients.

    DOI: 10.1016/j.ajem.2023.06.038

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  • Emphysematous pyelonephritis with ST elevation accompanied by reciprocal changes mimicking acute coronary syndrome

    Hatakeyama, K; Shono, Y; Hashimoto, T; Sakamoto, T; Nishihara, M; Iyonaga, T; Mizuguchi, S; Sakamoto, T; Maki, J; Akahoshi, T

    AMERICAN JOURNAL OF EMERGENCY MEDICINE   70   208e5 - 208e7   2023.8   ISSN:0735-6757 eISSN:1532-8171

  • Emphysematous pyelonephritis with ST elevation accompanied by reciprocal changes mimicking acute coronary syndrome

    Kiwamu Hatakeyama, Yuji Shono, Takuma Hashimoto, Taiki Sakamoto, Masaaki Nishihara, Takeshi Iyonaga, Soichi Mizuguchi, Takafumi Sakamoto, Jun Maki, Tomohiko Akahoshi

    American Journal of Emergency Medicine   70   208.e5 - 208.e7   2023.8   ISSN:0735-6757 eISSN:1532-8171

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    Publishing type:Research paper (scientific journal)  

    Patients with infectious diseases including sepsis can develop ST segment changes on an electrocardiogram (ECG) in the absence of coronary artery disease. However, ST elevation with “reciprocal ST segment depression (RSTD)”, which is recognized as a specific finding for ST-elevated myocardial infarction, is rare in such patients. Although a small number of cases have reported ST-segment elevation in gastritis, cholecystitis, and sepsis, regardless of coronary artery disease, none presented with reciprocal changes. Here, we describe a rare case of a patient with emphysematous pyelonephritis complicating septic shock who developed ST elevation accompanied by reciprocal changes with no coronary occlusion. Emergency physicians should consider the possibility of acute coronary syndrome mimicking, and choose non-invasive diagnostic procedures when investigating the causes of ECG abnormalities associated with critically ill patients.

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  • 院外心停止に対するECPRにおける経食道心エコーの有用性についての検討

    高橋 慶多, 高森 信之介, 大屋 皆既, 崎村 正太郎, 畠山 究, 彌永 武史, 西原 正章, 赤星 朋比古, 牧 盾, 山浦 健

    日本集中治療医学会雑誌   30 ( Suppl.1 )   S756 - S756   2023.6   ISSN:1340-7988 eISSN:1882-966X

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    Language:Japanese   Publisher:(一社)日本集中治療医学会  

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  • 高エネルギー外傷患者における集中治療と逸脱酵素との関連についての検討

    崎村 正太郎, 大屋 皆既, 高森 信乃介, 高橋 慶多, 大澤 さやか, 牧 盾, 徳田 賢太郎, 赤星 朋比古, 山浦 健

    日本集中治療医学会雑誌   30 ( Suppl.1 )   S789 - S789   2023.6   ISSN:1340-7988 eISSN:1882-966X

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  • 減量・代謝改善手術ネクストステージ 減量・代謝改善手術の対象患者における,新規肝機能推定装置の開発

    長尾 吉泰, 兵藤 文紀, 村田 正治, 小斉 侑希子, 冨野 高広, 吉屋 匠平, 戸島 剛男, 武石 一樹, 森田 和豊, 井口 友宏, 伊藤 心二, 原田 昇, 二宮 瑞樹, 前田 貴司, 赤星 朋比古, 江藤 正俊, 吉住 朋晴

    日本外科学会定期学術集会抄録集   123回   SY - 3   2023.4

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  • 減量・代謝改善手術ネクストステージ 減量・代謝改善手術の対象患者における,新規肝機能推定装置の開発

    長尾 吉泰, 兵藤 文紀, 村田 正治, 小斉 侑希子, 冨野 高広, 吉屋 匠平, 戸島 剛男, 武石 一樹, 森田 和豊, 井口 友宏, 伊藤 心二, 原田 昇, 二宮 瑞樹, 前田 貴司, 赤星 朋比古, 江藤 正俊, 吉住 朋晴

    日本外科学会定期学術集会抄録集   123回   SY - 3   2023.4

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  • Infantile thermal epiglottitis successfully managed without intubation

    Kondo T., Kaku N., Akahoshi T.

    Visual Journal of Emergency Medicine   31   2023.4

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    Publisher:Visual Journal of Emergency Medicine  

    DOI: 10.1016/j.visj.2023.101649

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  • 外傷性頭蓋内血腫を合併した胸椎脱臼骨折に対する脊椎固定術後に頭蓋内血腫が増大した1例

    河野 通仁, 籾井 健太, 木原 大護, 田丸 哲弥, 牧 盾, 小早川 和, 川口 謙一, 赤星 朋比古, 中島 康晴

    整形外科と災害外科   72 ( 1 )   128 - 131   2023.3   ISSN:00371033 eISSN:13494333

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    Language:Japanese   Publisher:西日本整形・災害外科学会  

    <p>【はじめに】脊椎術後の頭蓋内出血はまれではあるが報告されている.しかし,頭部外傷を合併した脊椎外傷の術後合併症としてのテント上硬膜下血腫の報告はない.【症例】29歳,男性.4階から墜落して,右急性硬膜下血腫,第12胸椎脱臼骨折を含む胸腰椎多発骨折を受傷した.頭部外傷は保存的治療を選択し,CTによる厳密な評価を行った.血腫の増大はなく脳浮腫が改善した第7病日に,脊椎後方固定術を行った.第10病日に意識障害を来たし,CTで右慢性硬膜下血腫による鉤ヘルニアと診断した.穿頭血腫除去術を行い,速やかに意識は改善した.【考察】脊椎手術後合併症として,小脳出血の報告は多いが,テント上の頭蓋内出血はまれである.過去の頭部外傷が危険因子と考えられているが,報告は少ない.頭部外傷を合併した患者における脊椎手術では,術後に頭蓋内出血を合併する可能性を考慮し,意識の変容の有無を慎重に観察する必要がある.</p>

    DOI: 10.5035/nishiseisai.72.128

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  • 外傷性頭蓋内血腫を合併した胸椎脱臼骨折に対する脊椎固定術後に頭蓋内血腫が増大した1例

    河野 通仁, 籾井 健太, 木原 大護, 田丸 哲弥, 牧 盾, 小早川 和, 川口 謙一, 赤星 朋比古, 中島 康晴

    整形外科と災害外科   72 ( 1 )   128 - 131   2023.3   ISSN:0037-1033

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    【はじめに】脊椎術後の頭蓋内出血はまれではあるが報告されている.しかし,頭部外傷を合併した脊椎外傷の術後合併症としてのテント上硬膜下血腫の報告はない.【症例】29歳,男性.4階から墜落して,右急性硬膜下血腫,第12胸椎脱臼骨折を含む胸腰椎多発骨折を受傷した.頭部外傷は保存的治療を選択し,CTによる厳密な評価を行った.血腫の増大はなく脳浮腫が改善した第7病日に,脊椎後方固定術を行った.第10病日に意識障害を来たし,CTで右慢性硬膜下血腫による鉤ヘルニアと診断した.穿頭血腫除去術を行い,速やかに意識は改善した.【考察】脊椎手術後合併症として,小脳出血の報告は多いが,テント上の頭蓋内出血はまれである.過去の頭部外傷が危険因子と考えられているが,報告は少ない.頭部外傷を合併した患者における脊椎手術では,術後に頭蓋内出血を合併する可能性を考慮し,意識の変容の有無を慎重に観察する必要がある.(著者抄録)

  • 2.5-mm articulated endoluminal forceps using a compliant mechanism

    Keisuke Osawa, D. S. V. Bandara, Ryu Nakadate, Yoshihiro Nagao, Tomohiko Akahoshi, Masatoshi Eto, Jumpei Arata

    International Journal of Computer Assisted Radiology and Surgery   18 ( 1 )   1 - 8   2023.1   ISSN:1861-6410 eISSN:1861-6429

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    DOI: 10.1007/s11548-022-02726-9

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  • Multimodal Telemonitoring for Weight Reduction in Patients With Sleep Apnea A Randomized Controlled Trial

    Murase, K; Minami, T; Hamada, S; Gozal, D; Takahashi, N; Nakatsuka, Y; Takeyama, H; Tanizawa, K; Endo, D; Akahoshi, T; Moritsuchi, Y; Tsuda, T; Toyama, Y; Ohi, M; Tomita, Y; Narui, K; Matsuyama, N; Ohdaira, T; Kasai, T; Tsuboi, T; Gon, Y; Yamashiro, Y; Ando, S; Yoshimine, H; Takata, Y; Yoshihisa, A; Tatsumi, K; Momomura, SI; Kuroda, T; Morita, S; Nakayama, T; Hirai, T; Chin, K

    CHEST   162 ( 6 )   1373 - 1383   2022.12   ISSN:0012-3692 eISSN:1931-3543

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    Background: Telemonitoring the use of CPAP devices and remote feedback on device data effectively optimizes CPAP adherence in patients with OSA. Research Question: Can expanding the scope of telemonitoring and remote feedback to body weight (BW), BP, and physical activity enhance efforts for BW reduction in Patients with OSA receiving CPAP? Study Design and Methods: Participants were recruited from patients at 16 sleep centers in Japan with OSA and obesity who were receiving CPAP therapy. Obesity was defined as a BMI of ≥ 25 kg/m2, based on Japanese obesity guidelines. Implementation of CPAP telemonitoring was enhanced with electronic scales, BP monitors, and pedometers that could transmit data from devices wirelessly. Participants were randomized to the multimodal telemonitoring group or the usual CPAP telemonitoring group and were followed up for 6 months. Attending physicians provided monthly telephone feedback calls to the usual CPAP telemonitoring group on CPAP data obtained remotely. In the multimodal telemonitoring group, physicians additionally encouraged participants to reduce their BW, after sharing the remotely obtained data on BW, BP, and step count. The primary outcome was set as ≥ 3% BW reduction from baseline. Results: One hundred sixty-eight participants (BMI, 31.7 ± 4.9 kg/m2) completed the study, and ≥ 3% BW reduction occurred in 33 of 84 participants (39.3%) and 21 of 84 participants (25.0%) in the multimodal telemonitoring and usual CPAP telemonitoring groups, respectively (P = .047). Whereas no significant differences were found between the two groups in the change in office and home BP, daily step counts during the study period were significantly higher in the multimodal telemonitoring group than in the usual CPAP telemonitoring group (4,767 steps/d [interquartile range (IQR), 2,864-6,617 steps/d] vs 3,592 steps/d [IQR, 2,117-5,383 steps/d]; P = .02) Interpretation: Multimodal telemonitoring may enhance BW reduction efforts in patients with OSA and obesity. Trial Registry: UMIN Clinical Trials Registry; No.: UMIN000033607; URL: www.umin.ac.jp/ctr/index.htm

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  • 脂肪塞栓症候群に合併した循環不全に一酸化窒素吸入が奏功した一例

    陣林 秀紀, 畠山 究, 籾井 健太, 吉本 将和, 桑原 正成, 彌永 武史, 西原 正章, 生野 雄二, 牧 盾, 中島 康晴, 赤星 朋比古

    日本救急医学会雑誌   33 ( 10 )   744 - 744   2022.10   ISSN:0915-924X eISSN:1883-3772

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  • Prediction of intracranial lesions in patients with consciousness disturbance by ultrasonography in the intensive care unit

    Yuji Shono, Satomi Mezuki, Tomohiko Akahoshi, Masaaki Nishihara, Noriyuki Kaku, Jun Maki, Kentaro Tokuda, Takanari Kitazono

    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH   50 ( 9 )   3000605221119358   2022.9   ISSN:0300-0605 eISSN:1473-2300

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    Objective: This study was performed to evaluate the correlation between parameters measured by bedside ultrasonography and detection of intracranial organic lesions in patients with impaired consciousness in an intensive care unit (ICU) setting.Methods: We retrospectively reviewed the medical records of patients who were admitted to our ICU from April 2017 to July 2019. Patients who underwent computed tomography or magnetic resonance imaging examination and measurement of the flow velocity of the carotid and intracranial arteries and the optic nerve sheath diameter by ultrasonography were selected for analysis.Results: In total, 64 patients were analyzed in this study. Of these, intracranial lesions were detected by computed tomography or magnetic resonance imaging in 17 (27%) patients. The left:right ratio of the end-diastolic velocity of the bilateral common carotid artery (CCA-ED ratio) and the pulsatility index of the middle cerebral artery (MCA-PI) were significantly higher in patients with than in those without intracranial lesions. The cut-off value of the CCA-ED ratio was 1.55 (sensitivity, 66.7%; specificity, 81.6%), and that of the MCA-PI was 1.21 (sensitivity, 57.1%; specificity, 76.7%).Conclusion: Bedside ultrasonography is useful for predicting intracranial lesions requiring therapeutic intervention in ICU patients with impaired consciousness.

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  • Noninvasive Diagnosis of the Mitochondrial Function of Doxorubicin-Induced Cardiomyopathy Using In Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging. International journal

    Yukie Mizuta, Tomohiko Akahoshi, Hinako Eto, Fuminori Hyodo, Masaharu Murata, Kentaro Tokuda, Masatoshi Eto, Ken Yamaura

    Antioxidants (Basel, Switzerland)   11 ( 8 )   2022.7   ISSN:2076-3921 eISSN:2076-3921

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    Doxorubicin (DOX) induces dose-dependent cardiotoxicity via oxidative stress and abnormal mitochondrial function in the myocardium. Therefore, a noninvasive in vivo imaging procedure for monitoring the redox status of the heart may aid in monitoring diseases and developing treatments. However, an appropriate technique has yet to be developed. In this study, we demonstrate a technique for detecting and visualizing the redox status of the heart using in vivo dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) with 3-carbamoyl-PROXYL (CmP) as a molecular imaging probe. Male C57BL/6N mice were administered DOX (20 mg/kg) or saline. DNP-MRI clearly showed a slower DNP signal reduction in the DOX group than in the control group. Importantly, the difference in the DNP signal reduction rate between the two groups occurred earlier than that detected by physiological examination or clinical symptoms. In an in vitro experiment, KCN (an inhibitor of complex IV in the mitochondrial electron transport chain) and DOX inhibited the electron paramagnetic resonance change in H9c2 cardiomyocytes, suggesting that the redox metabolism of CmP in the myocardium is mitochondrion-dependent. Therefore, this molecular imaging technique has the potential to monitor the dynamics of redox metabolic changes in DOX-induced cardiomyopathy and facilitate an early diagnosis of this condition.

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  • 竹串が頭蓋腔に穿通した上顎顔面損傷(Maxillofacial injury caused by bamboo skewer penetrating the cranial cavity)

    Kondo Takuya, Kaku Noriyuki, Hanaki Yuka, Tsuchihashi Nana, Akahoshi Tomohiko

    Pediatrics International   64 ( 1 )   1 of 2 - 2 of 2   2022.3   ISSN:1328-8067

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    症例は1歳男児で、竹串による上顎顔面損傷のため救急搬送された。竹串は口腔前庭上部に約5cm穿通していると考えられた。鼻血を除き、バイタルサインや検査値は正常であった。CTにて、竹串が篩骨を貫通し頭蓋内腔に達していたが、明らかな頭蓋内出血や脳損傷はなかった。髄膜脳炎予防のため抗生物質投与を開始し、経鼻ファイバースコープを用いて鎮静下で竹串を抜去した。鼻性髄液漏や出血は認められなかった。処置後のCTにて気頭症を認め、抗生物質を継続した。入院中、体温は39.8℃に達し、白血球数とC反応性蛋白が増加したが、2日目の髄液検査では髄膜脳炎を認めなかった。徐々に発熱と検査値が改善し、3日目に経口摂取を開始した。静脈内抗生物質療法を2週間継続し、14日目に症状なく退院した。

  • Stress Dispersion Design in Continuum Compliant Structure toward Multi-DOF Endoluminal Forceps

    Keisuke Osawa, D. S. V. Bandara, Ryu Nakadate, Yoshihiro Nagao, Tomohiko Akahoshi, Masatoshi Eto, Jumpei Arata

    Applied Sciences   12 ( 5 )   2480 - 2480   2022.3   eISSN:2076-3417

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    Gastrointestinal cancer, when detected early, is treated by accessing the lesion through the natural orifice using flexible endoscopes. However, the limited degree-of-freedom (DOF) of conventional treatment devices and the narrow surgical view through the endoscope demand advanced techniques. In contrast, multi-DOF forceps systems are an excellent alternative; however, these systems often involve high fabrication costs because they require a large number of micro-parts. To solve this problem, we designed compact multi-DOF endoluminal forceps with a monolithic structure comprising compliant hinges. To allow an efficient stress dispersion at the base end when the hinge bends, we proposed a novel design method to obtain the hinge parameters using the beam of uniform strength theory. This method does not involve a high computational cost. The results show that the improved design with a variable hinge thickness can reduce the maximum bending stress, dispersing the stress in a larger area than that of the previous design considering a constant thickness of the hinge. Moreover, the experiments conducted in a prototype confirm that the radius of the curvature was significantly improved. The proposed method could aid in designing other continuum robots relying on compliant hinges.

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  • Radiation Emergency Medical Preparedness in Japan: A Survey of Nuclear Emergency Core Hospitals

    Nagata, T; Arishima, T; Yamaguchi, Y; Hirohashi, N; Usa, T; Hasegawa, A; Hanada, H; Yamamoto, N; Okamoto, T; Akahoshi, T; Hamada, M; Abe, T; Kikukawa, M; Nakao, H; Yamamura, H; Sakamoto, T; Akashi, M; Hagihara, A

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS   17 ( 2 )   e78   2022.2   ISSN:1935-7893 eISSN:1938-744X

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    Objective: Based on experiences following the Great East Japan Earthquake and nuclear power plant accident in 2011, Nuclear Emergency Core Hospitals (NECHs) were designated as centers for radiation disaster management in Japan. This study aimed to investigate their current status and identify areas for improvement. Methods: This cross-sectional study was conducted in October 2018. Demographic data were collected by a questionnaire with free text responses about attitudes toward NECHs. Considerations regarding risk communications during a radiation disaster were analyzed using qualitative text mining analysis. Results: A total of 36 hospitals participated in this study. Only 31% of NECHs anticipated a radiation disaster. The importance of business continuity plans and risk communications was shown. Text analysis identified 7 important categories for health care workers during a radiation disaster, including media response, communications to hospital staff, risk communications, radiation effects on children, planning for a radiation disaster in the region, rumors, and the role in the region. Conclusion: The radiation disaster medical system and NECHs in Japan were surveyed. The importance of risk communications, planning for a radiation disaster in each region, and the role in the region are identified as issues that need to be addressed.

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  • Maxillofacial injury caused by bamboo skewer penetrating the cranial cavity

    Kondo, T; Kaku, N; Hanaki, Y; Tsuchihashi, N; Akahoshi, T

    PEDIATRICS INTERNATIONAL   64 ( 1 )   e15018   2022.1   ISSN:1328-8067 eISSN:1442-200X

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  • Impact of Antithrombin Activity Levels Following Recombinant Antithrombin Gamma Therapy in Patients with Sepsis-Induced Disseminated Intravascular Coagulation. International journal

    Tomohiko Akahoshi, Noriyuki Kaku, Yuji Shono, Yuzo Yamamoto, Keita Takahashi, Takeshi Iyonaga, Kenta Momii, Masaaki Nishihara, Jun Maki, Kentaro Tokuda, Ken Yamaura

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis   28   10760296221135790 - 10760296221135790   2022   ISSN:1076-0296 eISSN:1938-2723

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    Recombinant antithrombin gamma (rAT) is reported as an effective drug for patients with disseminated intravascular coagulation (DIC) in Japan. As the appropriate dose and targeted AT activity remain unknown, this study aimed to determine these aspects for sepsis-induced DIC. Thirty-one patients with septic shock and DIC with AT levels <70% were treated with rAT between May 2018 and December 2020. The recovery rates from DIC were 32.2% and 63.3% on day 3 and 5 post administration, respectively. Recovery and survival rates were significantly higher in patients who achieved AT activity ≥70% or 80% on day 3 post administration. Receiver operating characteristic curve analysis revealed that the cutoff values of post-treatment AT activity on day 3 for 28-day survival and 5-day recovery from DIC were 79.5% and 81.5%, respectively. Patients who did not achieve AT activity ≥80% on day 3 presented a lower base level of AT activity and lower dose supplementation. Our results suggest that targeted AT activity should be at least 70%, and ideally 80%, and sufficient doses to maintain this activity are required to achieve better outcomes.

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  • 門脈圧亢進症の病態

    赤星 朋比古

    門脈圧亢進症取り扱い規約 第 4 版 日本門脈圧亢進症学会編 金原出版   第4版   11 - 18   2022

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  • Development of Handheld Multi-DOF Endoluminal Forceps using Compliant Mechanism

    OSAWA Keisuke, BANDARA D.S.V., NAKADATE Ryu, NAGAO Yoshihiro, AKAHOSHI Tomohiko, ETO Masatoshi, ARATA Jumpei

    The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec)   2022 ( 0 )   1P1-M10   2022   eISSN:24243124

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    <p>Multi-DOF (Degree of Freedom) endoluminal forceps is a useful device for assisting endoscopic treatment. However, articulating endoluminal forceps with conventional mechanism have a large number of parts, thus have some problems such as size and cost. Multi-DOF endoluminal forceps using a compliant mechanism has a smaller number of parts, and is advantageous in terms of miniaturization and cost reduction. In this study, we developed a mechanical handheld device without a motor. In order to accurately manipulate the bending motion of forceps with a joystick, a force transmission model has been formulated. With reference to this force transmission model, a prototype was manufactured with a 3D printer. Finally, we succeeded in lifting the simulated intestinal mucous membrane by the prototyped forceps, confirming the effectiveness of the proposed method.</p>

    DOI: 10.1299/jsmermd.2022.1p1-m10

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  • Reflectance spectra analysis for mucous assessment. International journal

    Toru Chiba, Masaharu Murata, Takahito Kawano, Makoto Hashizume, Tomohiko Akahoshi

    World journal of gastrointestinal oncology   13 ( 8 )   822 - 834   2021.8

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    DOI: 10.4251/wjgo.v13.i8.822

  • In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics. International journal

    Fuminori Hyodo, Hinako Eto, Tatsuya Naganuma, Norikazu Koyasu, Abdelazim Elsayed Elhelaly, Yoshifumi Noda, Hiroki Kato, Masaharu Murata, Tomohiko Akahoshi, Makoto Hashizume, Hideo Utsumi, Masayuki Matsuo

    Antioxidants & redox signaling   36 ( 1-3 )   172 - 184   2021.7   ISSN:1523-0864 eISSN:1557-7716

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  • Histidine-Rich Glycoprotein Alleviates Liver Ischemia/Reperfusion Injury in Mice With Nonalcoholic Steatohepatitis. International journal

    Jie Guo, Tomohiko Akahoshi, Yukie Mizuta, Masaharu Murata, Sayoko Narahara, Takahito Kawano, Yoshihiro Nagao, Shuo Zhang, Morimasa Tomikawa, Hirofumi Kawanaka, Makoto Hashizume

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society   27 ( 6 )   840 - 853   2021.6

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  • Development of 20 cm sample bore size dynamic nuclear polarization (DNP)-MRI at 16 mT and redox metabolic imaging of acute hepatitis rat model. International journal

    169   149 - 157   2021.6

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    Tissue redox metabolism is involved in various diseases, and an understanding of the spatio-temporal dynamics of tissue redox metabolism could be useful for diagnosis of progression and treatment. In in vivo dynamic nuclear polarization (DNP)-MRI, electron paramagnetic resonance (EPR) irradiation at the resonance frequency of nitroxyl radicals administered as a redox probe for induction of DNP, increases the intensity of MRI signals. For electron spin, it is necessary to apply a resonant frequency 658 times higher than that required for nuclear spin because of the higher magnetic moment of unpaired electrons. Previous studies using a disease model of small animals and in vivo DNP-MRI have revealed that an abnormal redox status is involved in many diseases, and that it could be used to visualize the dynamics of alterations in redox metabolism. To use the current methods in clinical practice, the development of a prototype DNP-MRI system for preclinical examinations of large animals is indispensable for clarifying the problems peculiar to the increase in size of the DNP-MRI device. Therefore, we developed a in vivo DNP-MRI system with a sample bore size of 20 cm and a 16-mT magnetic field using a U-shaped permanent magnet. Because the NMR frequency is very low, we adopted a digital radiofrequency transmission/reception system with excellent filter and dynamic range characteristics and equipped with a digital eddy current compensation system to suppress large eddy currents. The pulse sequence was based on the fast spin-echo sequence, which was improved for low frequency and large-eddy current equipment. The in vivo DNP-MRI system developed was used to non-invasively image the redox reaction of a carbamoyl-PROXYL probe in the livers of large rats weighing 800 g. Furthermore, DNP-MRI analysis was able to capture significant changes in redox metabolism in hepatitis-model rats.

    DOI: 10.1016/j.freeradbiomed.2021.04.017

  • Efficacy of thromboelastography in the management of anticoagulation for veno-venous extracorporeal membrane oxygenation in a coronavirus disease 2019 patient: A case report. International journal

    Ryosuke Nakashima, Masaaki Nishihara, Takeshi Iyonaga, Sho Iwasaka, Yuzo Yamamoto, Yuji Shono, Jun Maki, Kentaro Tokuda, Tomohiko Akahoshi, Taiki Higo, Takanari Kitazono, Hiroyuki Tsutsui

    Medicine   100 ( 23 )   e26313   2021.6

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  • Free radical imaging of endogenous redox molecules using dynamic nuclear polarization magnetic resonance imaging. International journal

    Fuminori Hyodo, Shinji Ito, Hinako Eto, Abdelazim Elsayed Elhelaly, Masaharu Murata, Tomohiko Akahoshi, Hideo Utsumi, Masayuki Matuso

    Free radical research   55 ( 4 )   343 - 351   2021.4

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    DOI: 10.1080/10715762.2020.1859109

  • Wireless Light-emitting Marker Using Magnetic Field Resonance for Laparoscopic Gastrointestinal Surgery. International journal

    Masahiko Sugiyama, Yoshihiro Nagao, Hideo Uehara, Masaki Kagawa, Yuki Shin, Keiichi Shiokawa, Mitsuhiko Ota, Tomohiko Akahoshi, Masaru Morita

    Surgical laparoscopy, endoscopy & percutaneous techniques   2021.3

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    DOI: 10.1097/SLE.0000000000000929

  • Use of venovenous extracorporeal membrane oxygenation for perioperative management of acute respiratory distress syndrome caused by fat embolism syndrome: A case report and literature review. International journal

    Kenta Momii, Yuji Shono, Kanji Osaki, Yoshinori Nakanishi, Takeshi Iyonaga, Masaaki Nishihara, Tomohiko Akahoshi, Yasuharu Nakashima

    Medicine   100 ( 8 )   e24929   2021.2

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  • Prognostic factors for the short-term mortality of patients with rheumatoid arthritis admitted to intensive care units. International journal

    Toshifumi Fujiwara, Kentaro Tokuda, Kenta Momii, Kyohei Shiomoto, Hidetoshi Tsushima, Yukio Akasaki, Satoshi Ikemura, Jun-Ichi Fukushi, Jun Maki, Noriyuki Kaku, Tomohiko Akahoshi, Tomoaki Taguchi, Yasuharu Nakashima

    BMC rheumatology   4 ( 1 )   64 - 64   2020.12

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  • Clinical improvement in a patient with severe coronavirus disease 2019 after administration of hydroxychloroquine and continuous hemodiafiltlation with nafamostat mesylate. International journal

    Sho Iwasaka, Yuji Shono, Kentaro Tokuda, Kosuke Nakashima, Yuzo Yamamoto, Jun Maki, Yoji Nagasaki, Nobuyuki Shimono, Tomohiko Akahoshi, Tomoaki Taguchi

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   26 ( 12 )   1319 - 1323   2020.12

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    DOI: 10.1016/j.jiac.2020.08.001

  • Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells. International journal

    Yukie Mizuta, Tomohiko Akahoshi, Jie Guo, Shuo Zhang, Sayoko Narahara, Takahito Kawano, Masaharu Murata, Kentaro Tokuda, Masatoshi Eto, Makoto Hashizume, Ken Yamaura

    Stem cell research & therapy   11 ( 1 )   508 - 508   2020.11

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    DOI: 10.1186/s13287-020-02015-9

  • Development of a novel molecular probe for the detection of liver mitochondrial redox metabolism. International journal

    Md Zahangir Hosain, Fuminori Hyodo, Takeshi Mori, Koyo Takahashi, Yusuke Nagao, Hinako Eto, Masaharu Murata, Tomohiko Akahoshi, Masayuki Matsuo, Yoshiki Katayama

    Scientific reports   10 ( 1 )   16489 - 16489   2020.10

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    DOI: 10.1038/s41598-020-73336-1

  • Sodium thiosulfate prevents doxorubicin-induced DNA damage and apoptosis in cardiomyocytes in mice. International journal

    Yukie Mizuta, Kentaro Tokuda, Jie Guo, Shuo Zhang, Sayoko Narahara, Takahito Kawano, Masaharu Murata, Ken Yamaura, Sumio Hoka, Makoto Hashizume, Tomohiko Akahoshi

    Life sciences   257   118074 - 118074   2020.9

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    DOI: 10.1016/j.lfs.2020.118074

  • The farnesyltransferase inhibitor tipifarnib protects against autoimmune hepatitis induced by Concanavalin A. International journal

    Jie Guo, Kazuhiro Shirozu, Tomohiko Akahoshi, Yukie Mizuta, Masaharu Murata, Ken Yamaura

    International immunopharmacology   83   106462 - 106462   2020.6

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    DOI: 10.1016/j.intimp.2020.106462

  • The importance of simulation education for the management of traumatic cardiac injuries: a case series. International journal

    Takashi Nagata, Tomohiko Akahoshi, Michiko Sugino, Wataru Ishii, Ryoji Iizuka, Takafumi Shinjo, Yoshimitsu Izawa, Michiaki Hata, Alan Kawarai Lefor

    Surgical case reports   5 ( 1 )   202 - 202   2019.12

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  • The evolution of surgical treatment for gastrointestinal cancers.

    Yoshihiko Maehara, Yuji Soejima, Tomoharu Yoshizumi, Naoyuki Kawahara, Eiji Oki, Hiroshi Saeki, Tomohiko Akahoshi, Toru Ikegami, Yo-Ichi Yamashita, Tadashi Furuyama, Keishi Sugimachi, Noboru Harada, Tetsuzo Tagawa, Norifumi Harimoto, Shinji Itoh, Hideto Sonoda, Koji Ando, Yuichiro Nakashima, Yoshihiro Nagao, Nami Yamashita, Yuta Kasagi, Takafumi Yukaya, Takeshi Kurihara, Ryosuke Tsutsumi, Shinkichi Takamori, Shun Sasaki, Tetsuo Ikeda, Yoshikazu Yonemitsu, Takasuke Fukuhara, Hiroyuki Kitao, Makoto Iimori, Yuki Kataoka, Takeshi Wakasa, Masami Suzuki, Koji Teraishi, Yasuto Yoshida, Masaki Mori

    International journal of clinical oncology   24 ( 11 )   1333 - 1349   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-019-01499-7

  • Advanced multispectral image-processing endoscopy system for visualizing two-dimensional hemoglobin saturation and relative hemoglobin concentration. International journal

    Toru Chiba, Yoshimi Obara, Masaharu Murata, Tomohiko Akahoshi

    Endoscopy international open   7 ( 11 )   E1442-E1447   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/a-0990-9189

  • Successful use of flexible silicone mesh for management of prolonged open abdomen. International journal

    Ryosuke Tsutsumi, Tomohiko Akahoshi, Tetsuo Ikeda, Yoshihiko Maehara, Makoto Hashizume

    Acute medicine & surgery   6 ( 4 )   400 - 403   2019.10

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    Language:English  

    DOI: 10.1002/ams2.438

  • Japanese periodical nationwide epidemiologic survey of aberrant portal hemodynamics. International journal

    Satoko Ohfuji, Yoshihiro Furuichi, Tomohiko Akahoshi, Masayoshi Kage, Katsutoshi Obara, Makoto Hashizume, Tomoka Matsuura, Wakaba Fukushima, Yosikazu Nakamura

    Hepatology research : the official journal of the Japan Society of Hepatology   49 ( 8 )   890 - 901   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.13343

  • Colorectal endoscopic submucosal dissection using novel articulating devices: a comparative study in a live porcine model. International journal

    Yasuharu Okamoto, Ryu Nakadate, Shotaro Nakamura, Jumpei Arata, Susumu Oguri, Tomohiko Moriyama, Motohiro Esaki, Tsutomu Iwasa, Kenoki Ohuchida, Tomohiko Akahoshi, Tetsuo Ikeda, Takanari Kitazono, Makoto Hashizume

    Surgical endoscopy   33 ( 2 )   651 - 657   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00464-018-6408-5

  • A new robotic-assisted flexible endoscope with single-hand control: endoscopic submucosal dissection in the ex vivo porcine stomach. Reviewed International journal

    Tsutomu Iwasa, Ryu Nakadate, Shinya Onogi, Yasuharu Okamoto, Jumpei Arata, Susumu Oguri, Haruei Ogino, Eikichi Ihara, Kenoki Ohuchida, Tomohiko Akahoshi, Tetsuo Ikeda, Yoshihiro Ogawa, Makoto Hashizume

    Surgical endoscopy   32 ( 7 )   3386 - 3392   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00464-018-6188-y

  • In vivo redox metabolic imaging of mitochondria assesses disease progression in non-alcoholic steatohepatitis. International journal

    Ryosuke Nakata, Fuminori Hyodo, Masaharu Murata, Hinako Eto, Tomoko Nakaji, Takahito Kawano, Sayoko Narahara, Keiji Yasukawa, Tomohiko Akahoshi, Morimasa Tomikawa, Makoto Hashizume

    Scientific reports   7 ( 1 )   17170 - 17170   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-17447-2

  • Clinical characteristics of type A acute aortic dissection with CNS symptom. International journal

    Yuji Shono, Tomohiko Akahoshi, Satomi Mezuki, Kenta Momii, Noriyuki Kaku, Jun Maki, Kentaro Tokuda, Tetsuro Ago, Takanari Kitazono, Yoshihiko Maehara

    The American journal of emergency medicine   35 ( 12 )   1836 - 1838   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajem.2017.06.011

  • Noninvasive mapping of the redox status of dimethylnitrosamine-induced hepatic fibrosis using in vivo dynamic nuclear polarization-magnetic resonance imaging Reviewed

    Takahito Kawano, Masaharu Murata, Fuminori Hyodo, Hinako Eto, Nuttavut Kosem, Ryosuke Nakata, Nobuhito Hamano, Jing Shu Piao, Sayoko Narahara, Tomohiko Akahoshi, Makoto Hashizume

    SCIENTIFIC REPORTS   6   32604   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep32604

  • Splenectomy enhances the therapeutic effect of adipose tissue-derived mesenchymal stem cell infusion on cirrhosis rats Reviewed

    Wei-Ping Tang, Tomohiko Akahoshi, Jing-Shu Piao, Sayoko Narahara, Masaharu Murata, Takahito Kawano, Nobuhito Hamano, Tetsuo Ikeda, Makoto Hashizume

    LIVER INTERNATIONAL   36 ( 8 )   1151 - 1159   2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/liv.12962

  • Integrated Endoscopic System Based on Optical Imaging and Hyperspectral Data Analysis for Colorectal Cancer Detection Reviewed

    Ryuichi Kumashiro, Kozo Konishi, Tohru Chiba, Tomohiko Akahoshi, Shotaro Nakamura, Masaharu Murata, Morimasa Tomikawa, Takayuki Matsumoto, Yoshihiko Maehara, Makoto Hashizume

    ANTICANCER RESEARCH   36 ( 8 )   3925 - 3932   2016.8

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  • Basic fibroblast growth factor-treated adipose tissue-derived mesenchymal stem cell infusion to ameliorate liver cirrhosis via paracrine hepatocyte growth factor Reviewed

    Wei-Ping Tang, Tomohiko Akahoshi, Jing-Shu Piao, Sayoko Narahara, Masaharu Murata, Takahito Kawano, Nobuhito Hamano, Tetsuo Ikeda, Makoto Hashizume

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30 ( 6 )   1065 - 1074   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.12893

  • Intraoperative visualization of cerebral oxygenation using hyperspectral image data: a two-dimensional mapping method Reviewed

    Megumu Mori, Toru Chiba, Akira Nakamizo, Ryuichi Kumashiro, Masaharu Murata, Tomohiko Akahoshi, Morimasa Tomikawa, Yuichiro Kikkawa, Koji Yoshimoto, Masahiro Mizoguchi, Tomio Sasaki, Makoto Hashizume

    INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY   9 ( 6 )   1059 - 1072   2014.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11548-014-0989-9

  • Comparison of recombinant human thrombomodulin and gabexate mesylate for treatment of disseminated intravascular coagulation(DIC) with sepsis following emergent Gastrointestinal surgery: a retrospective study. International journal

    20   2014.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00068-014-0478-4

  • [Optimum hepatic parenchymal dissection to prevent bile leak: a comparative study using electrosurgical and stapling devices in swine]. Reviewed

    Tetsuo Ikeda, Tomohiko Akahoshi, Hirofumi Kawanaka, Hideaki Uchiyama, Yo-ichi Yamashita, Masaru Morita, Eiji Oki, Hiroshi Saeki, Keishi Sugimachi, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Ken Shirabe, Koshi Mimori, Masayuki Watanabe, Makoto Hashizume, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   104 ( 12 )   507 - 14   2013.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.15017/1440929

  • The Effect of Proton Pomp Inhibitor(PPI : Rabeprazole) on Reflux Esophagitis after Endoscopic Injection Sclerotherapy(EIS), a Randomized Control Study(24 hour-pH monitoring)

    Tomohiko Akahoshi, Hirofumi Kawanaka, MORIMASA TOMIKAWA, Hiroshi Saeki, Hideaki Uchiyama, Tetsuo Ikeda, Ken Shirabe, Makoto Hashizume, Yoshihiko Maehara

    104 ( 12 )   483 - 489   2013.12

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  • Effect of proton pomp inhibitor (PPI : Rabeprazole) on reflux esophagitis after endoscopic injection sclerotherapy (EIS), a randomized control study (24 hour-pH monitoring). Reviewed

    Tomohiko Akahoshi, Hirofumi Kawanaka, Morimasa Tomikawa, Hiroshi Saeki, Hideaki Uchiyama, Tetsuo Ikeda, Ken Shirabe, Makoto Hashizume, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   104 ( 12 )   483 - 9   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.15017/1440926

  • Evaluation of a transection method for distal pancreatectomy: A comparative study on the use of electrosurgical and stapling devices in swine. Reviewed

    Tetsuo Ikeda, Tomohiko Akahoshi, Hirofumi Kawanaka, Hideaki Uchiyama, Yo-ichi Yamashita, Masaru Morita, Eiji Oki, Hiroshi Saeki, Keishi Sugimachi, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Ken Shirabe, Koshi Mimori, Masayuki Watanabe, Makoto Hashizume, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   104 ( 12 )   515 - 22   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.15017/1440930

  • [Total laparoscopic splenectomy for a patient with multiple surgeries including living donor liver transplantation]. Reviewed

    Hiroko Yano, Toru Ikegami, Tomoharu Yoshizumi, Tomohiko Akahoshi, Morimasa Tomikawa, Hideaki Uchiyama, Yuji Soejima, Ken Shirabe, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   104 ( 3 )   64 - 7   2013.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.15017/26659

  • Treatment of Bleeding Rectal Varices With Transumbilical Venous Obliteration of the Inferior Mesenteric Vein

    Hashimoto N, Akahoshi T, Kamori M, Tomikawa M, Yoshida,D, Nagao Y, Morita K, Kayashima H, Ikegami T, Yoshizumi T, Taketomi A, Shirabe K, Maehara Y.

    Surg Laparosc Endosc Percutan Tech, In press   2013.2

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  • Rigid and flexible endoscopic rendezvous in spatium peritonealis may be an effective tactic for laparoscopic megasplenectomy: significant implications for pure natural orifice translumenal endoscopic surgery.

    Tomikawa M, Akahoshi T, Kinjo N, Uehara H, Hashimoto N, Nagao Y, Kamori M, Kumashiro R, Maehara Y, Hashizume M.

    Surg Endosc   26 ( 12 )   2012.12

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  • Effect of laparoscopic splenectomy in patients with Hepatitis C and cirrhosis carrying IL28B minor genotype Reviewed

    Takashi Motomura, Ken Shirabe, Norihiro Furusyo, Tomoharu Yoshizumi, Toru Ikegami, Yuji Soejima, Tomohiko Akahoshi, Morimasa Tomikawa, Takasuke Fukuhara, Jun Hayashi, Yoshihiko Maehara

    BMC GASTROENTEROLOGY   12   158   2012.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1471-230X-12-158

  • Endothelin-1 derived from spleen-activated Rho-kinase pathway in rats with secondary biliary cirrhosis Reviewed

    Hideo Uehara, Tomohiko Akahoshi, Hirohumi Kawanaka, Naotaka Hashimoto, Yoshihiro Nagao, Morimasa Tomikawa, Akinobu Taketomi, Ken Shirabe, Makoto Hashizume, Yoshihiko Maehara

    HEPATOLOGY RESEARCH   42 ( 10 )   1039 - 1047   2012.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1872-034X.2012.01021.x

  • Quality of life after laparoscopy-assisted pylorus-preserving gastrectomy: an evaluation using a questionnaire mailed to the patients.

    Tomikawa M, Korenaga D, Akahoshi T, Kohshi K, Sugimachi K, Nagao Y, Tsutsumi N, Takenaka K, Kakeji Y, Hashizume M, Maehara Y.

    Surg Today   42 ( 7 )   2012.7

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  • 小児における腹腔鏡下虫垂切除の有用性およびnterval appendectomyの必要性について

    村守 克己、宗崎 良太, 家入 里志, 松浦 俊治, 永田 公二, 林田 真, 木下 義晶, 富川 盛雅, 橋爪 誠, 田口 智章

    臨牀と研究   89 ( 4 )   2012.4

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  • Roles of Vascular Endothelial Growth Factor and Endothelial Nitric Oxide Synthase During Revascularization and Regeneration After Partial Hepatectomy in a Rat Model Reviewed

    Daisuke Yoshida, Tomohiko Akahoshi, Hirofumi Kawanaka, Shohei Yamaguchi, Nao Kinjo, Akinobu Taketomi, Morimasa Tomikawa, Ken Shirabe, Yoshihiko Maehara, Makoto Hashizume

    SURGERY TODAY   41 ( 12 )   1622 - 1629   2011.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-010-4484-9

  • Rupture of jejunal varices treated by percutaneous transhepatic obliteration and endoscopic injection sclerotherapy with n-butyl-2-cyanoacrylate. International journal

    Akahoshi T, Tanoue K, Tomikawa M, Hashizume M, Sugimachi K.

    Endoscopy   33 ( 11 )   998 - 998   2001.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-2001-17919

  • Portal-systemic encephalopathy due to a congenital extrahepatic portosystemic shunt: three cases and literature review. International journal

    AkahoshiT, Nishizaki T, Wakasugi K, Mastuzaka T, Kume K, Yamamoto I, Sugimachi K.

    Hepatogastroenterology   47 ( 34 )   1113 - 1116   2000.7

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Books

  • 「手術」最新肝胆膵脾手術アトラス: Ⅳ.脾臓 5 門脈圧亢進症に対するシャント手術

    赤星 朋比古, 橋爪 誠( Role: Joint author)

    金原出版(株)  2013.5 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • 肝臓専門医テキスト (日本肝臓学会編)

    赤星 朋比古, 橋爪 誠( Role: Joint author)

    南江堂  2013.3 

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    Language:Japanese   Book type:Scholarly book

  • バルーン閉塞下逆行性経静脈塞栓術(B-RTO)

    赤星 朋比古

    2012.7 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • 腹腔鏡下Hassab手術「改訂版第2版」食道・胃静脈瘤

    赤星 朋比古( Role: Joint author)

    日本メディカルセンター  2001.1 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • 門脈圧亢進症の病態 門脈圧亢進症取り扱い規約 第 4 版

    赤星 朋比古

    金原出版  2022 

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    Total pages:8  

    CiNii Research

  • 消化器腹腔鏡下手術 肝臓・胆道・膵臓・脾臓 イラストと動画で理解する内視鏡外 科解剖と手技のコツ

    赤星 朋比古

    学研出版  2022 

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    Total pages:9  

    CiNii Research

  • 「手術」最新 肝胆膵脾手術アトラス: Ⅳ.脾臓 1 肝移植における脾臓摘出術

    吉住 朋晴, 池上 徹, 播本 憲史, 赤星 朋比古, 調 憲, 前原 喜彦( Role: Joint author)

    金原出版(株)  2013.5 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • 【手術前に必読 局所解剖】肝・胆・膵・脾の手術 胃・食道静脈瘤の手術に必要な局所解剖

    長尾吉泰, 赤星朋比古, 富川盛雅, 橋爪誠

    2012.11 

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    Language:Japanese   Book type:General book, introductory book for general audience

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Presentations

  • 消化管術後敗血症性DICに対するリコモジュリン投与の現状と治療成績

    赤星 朋比古

    第40回日本救急医学会総会  2012.11 

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    Event date: 2012.11

    Language:Others  

    Venue:京都   Country:Japan  

  • ワークショップ4 : 多発外傷のAcute care surgeryにおける消化器外科治療 「外傷初期診療における消化器外科医の関わりにおける諸問題と対策」

    赤星 朋比古, 永田 高志, 橋爪 誠

    第67回日本消化器外科学会総会  2012.7 

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    Event date: 2012.7

    Language:Japanese  

    Venue:富山   Country:Japan  

  • 肝硬変合併脾機能亢進症に対する腹腔鏡下脾臓摘出術と合併症についての検討

    赤星朋比古, 富川盛雅, 家守雅大, 長尾吉泰, 前原喜彦

    第65回日本消化器外科学会  2011.7 

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    Event date: 2011.7

    Language:Others   Presentation type:Symposium, workshop panel (public)  

    Venue:下関市   Country:Japan  

  • 食道胃静脈瘤出血に対する当院における救急体制

    赤星朋比古 杉森 宏, 橋爪 誠

    第38回日本救急医学会総会  2010.10 

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    Event date: 2010.10

    Language:Others   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 当科における食道静脈瘤に対する治療戦略と成績

    赤星朋比古, 富川盛雅, 家守雅大, 長尾吉泰, 橋爪 誠, 前原喜彦

    第17回日本門脈圧亢進症学会総会  2010.9 

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    Event date: 2010.9

    Language:Others   Presentation type:Symposium, workshop panel (public)  

    Venue:富山   Country:Japan  

  • 肝癌合併食道・胃静脈瘤に対する治療戦略

    赤星朋比古, 富川盛雅, 家守雅大, 長尾吉泰, 前原喜彦

    2010.8 

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    Event date: 2010.8

    Language:Others   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜市   Country:Japan  

  • 腔鏡手術に有用なOpen MRIを用いたリアルタイムナビゲーションシステムの開発

    赤星朋比古, 富川盛雅, 金城 直, 上原英雄, 橋本直隆, 長尾吉泰, 前原喜彦

    第110日本外科学会  2010.4 

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    Event date: 2010.4 - 2011.4

    Language:Others   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 難治性消化管静脈瘤に対する外科治療の意義

    赤星朋比古, 富川盛雅, 家守雅大, 長尾吉泰, 前原喜彦

    第46回日本腹部救急医学会総会  2010.3 

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    Event date: 2010.3

    Language:Others   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  • Laparoscopic splenectomy as a breakthrough of completion of peginterferon and ribavirin therapy in patients with HCV cirrhosis and hypersplenism International conference

    Tomohiko Akahoshi, MD, Hirofumi Kawanaka, MD, Morimasa Tomikawa, MD, Nao Kinjo, MD, Naotaka Hashimoto MD, Hideo Uehara MD, Yasutoshi Nagao MD, Yoshihiko Maehara, MD, FACS

    American sugical society congress  2009.5 

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    Event date: 2009.5

    Language:Others  

    Country:Japan  

  • 消化管術後敗血症性DICに対するリコモジュリン投与の現状と治療成績

    赤星 朋比古, 川中 博文, 森田 勝, 調 憲, 前原 喜彦, 橋爪 誠

    第50回日本腹部救急医学会総会  2014.3 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 内視鏡外科手術における客観的消化管縫合技術評価シュミレータの開発

    富川 盛雅, 植村 宗則, 布施 健一, 大内田 研宙, 赤星 朋比古, 宗﨑 良太, 家入 里志, 是永 大輔, 竹中 賢治, 橋爪 誠

    第26回日本内視鏡外科学会総会  2013.11 

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    Event date: 2013.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 腹腔鏡下袖状胃切除術における3D内視鏡・ViKYシステム・循環式気腹装置(エアシール)の有用性の検討

    富川 盛雅, 神代 竜一, 長尾 吉泰, 赤星 朋比古, 大内田 研宙, 家入 里志, 池田 哲夫, 是永 大輔

    第26回日本内視鏡外科学会総会  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 次世代内視鏡手術システムによる腹腔鏡下脾臓摘出術の経験

    赤星 朋比古, 川中 博文, 富川 盛雅, 池田 哲夫, 前原 喜彦, 橋爪 誠

    第26回日本内視鏡外科学会総会  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 九州大学病院における肥満手術の工夫-立体映像表示システムを用いた腹腔鏡下袖状胃切除術

    富川 盛雅, 神代 竜一, 長尾 吉泰, 赤星 朋比古, 田井 耕二, 大内田 研宙, 家入 里志, 是永 大輔, 竹中 賢治, 橋爪 誠

    第26回日本内視鏡外科学会総会  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • MDCTによる下部食道側副血行路の評価とEVL治療法後再発に関する検討

    赤星 朋比古, 富川 盛雅, 川中 博文, 前原 喜彦, 橋爪 誠

    第20回日本門脈圧亢進症学会総会  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 肝硬変症における脾機能制御の意義について

    川中 博文, 赤星 朋比古, 富川 盛雅, 調 憲, 橋爪 誠, 前原 喜彦

    第20回日本門脈圧亢進症学会総会  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 生体肝移植後に憎悪する食道胃静脈瘤に関する検討

    松本佳大, 赤星 朋比古, 調 憲, 川中 博文, 吉住 朋晴, 山下洋市, 二宮 瑞樹, 井口 友宏, 前原 喜彦

    第20回日本門脈圧亢進症学会総会  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 腹腔鏡下脾臓定期出術における合併症予防の工夫

    堤 敬文, 山口 翔平, 富川 盛雅, 赤星 朋比古, 杉山 雅彦, 太田 光彦, 木村 和恵, 楠本 哲也, 橋爪 誠, 前原 喜彦, 池尻 公二

    第20回日本門脈圧亢進症学会総会  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 腹腔鏡下脾臓定期出術における工夫―軟性内視鏡併用の試み

    富川 盛雅, 赤星 朋比古, 金城 直, 上原 英雄, 橋本 直隆, 長尾 吉泰, 橋爪 誠

    第20回日本門脈圧亢進症学会総会  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 重傷腹部外傷診療における消化器外科医のかかわりにおける問題と提言 ~我が国の重傷外傷診療には消化器外科医の力が不可欠である~

    赤星 朋比古, 永田 高志, 杉森 宏, 橋爪 誠

    第32回福岡救急医学会  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:北九州   Country:Japan  

  • 消化管術後敗血症性DICに対するリコモジュリン投与の現状と治療成績

    赤星 朋比古, 永田 高志, 杉森 宏, 橋爪 誠

    第68回日本消化器外科学会総会  2013.7 

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    Event date: 2013.7

    Language:Japanese  

    Venue:宮崎市   Country:Japan  

  • Modified observed-expected chart (modified O-E chart) を用いた小児救急患者の診療成績比較

    賀耒 典之, 六車 崇, 平田 悠一郎, 李 守永, 馬場 晴久, 藤﨑 毅一郎, 徳田 健太郎, 野田 英一郎, 漢那 朝雄, 赤星 朋比古, 藤村 直幸, 谷山 卓郎, 杉森 宏, 前原 喜彦

    日本集中治療医学会 九州地方会  2013.7 

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    Event date: 2013.7

    Language:Japanese  

    Venue:宮崎市   Country:Japan  

  • 成人間生体肝移植後の術後食道胃静脈瘤の危険因子と対策

    松本 佳大, 調 憲, 副島 雄二, 吉住 朋晴, 池上 徹, 赤星 朋比古, 播本 憲史, 戸島 剛男, 古屋 匠平, 中川原 英和, 木村 光一, 前原 喜彦

    第31回日本肝移植研究会  2013.7 

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    Event date: 2013.7

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • Clinical Application of the Diagnostic and Therapeutic Model Assisted by the Computational Anatomy International conference

    35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society  2013.7 

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    Event date: 2013.7

    Language:English  

    Country:Japan  

  • 術者あるいは指導的助手として内視鏡外科手術を経験していることの客観的評価とトレーニング指針

    富川 盛雅, 植村 宗則, 長尾 吉泰, 神代 竜一, 宗﨑 良太, 赤星 朋比古, 大内田 研宙, 家入 里志, 田上 和夫, 大平 猛, 橋爪 誠

    第25回 日本内視鏡外科学会総会  2012.12 

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    Event date: 2012.12

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 門脈圧亢進症および肝硬変患者における脾臓摘出術後の長期合併症に関する検討

    赤星朋比古, 富川盛雅, 長尾吉泰, 橋爪 誠, 前原喜彦

    第19回日本門脈圧亢進症学会  2012.9 

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    Event date: 2012.9

    Language:Others  

    Venue:東京   Country:Japan  

  • 流体力学的解析を応用した門脈圧推定の試み

    富川 盛雅, 長尾 吉泰, 赤星 朋比古, 橋爪 誠

    第19回日本門脈圧亢進症学会総会  2012.9 

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    Event date: 2012.9

    Language:Others  

    Venue:東京   Country:Japan  

  • 単孔式鼠径ヘルニア修復術に対するドーム型立体映像表示システムの有用性

    富川 盛雅, 長尾吉泰, 植村 宗則, 吉田正樹, 堀 淳一, 石井裕之, 大内田 研宙, 赤星 朋比古, 家入 里志, 大平 猛, 橋爪 誠

    第6回単孔式内視鏡手術研究会  2012.8 

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    Event date: 2012.8

    Language:Japanese  

    Venue:札幌   Country:Japan  

  • HMGB-1(high mobility group box1)が肝線維化におよぼす影響の検討

    橋本 直隆, 長尾 吉泰, 森田 和豊, 萱嶋 寛人, 増田 捻郎, 赤星朋比古, 池上 徹, 吉住 朋晴, 富川 盛雅, 調 憲, 前原 喜彦

    第67回日本消化器外科学会総会  2012.7 

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    Event date: 2012.7

    Language:Others  

    Venue:富山   Country:Japan  

  • ハイパースペクトルカメラを用いた大腸病変における酸化/還元型ヘモグロビンの濃度変化に関する検討

    神代 竜一, 赤星 朋比古, 武谷 憲二, 安藤 幸滋, 佐伯 浩司, 沖 英次, 富川 盛雅, 森田 勝, 掛地 吉弘, 前原 喜彦, 橋爪 誠

    第67回日本消化器外科学会総会  2012.7 

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    Event date: 2012.7

    Language:Japanese  

    Venue:富山   Country:Japan  

  • コンピューター診断支援システムNewVESを応用した消化器外科領域の治療シミュレーション

    富川 盛雅, 小田 昌宏, 神代 竜一, 赤星 朋比古, 橋本 直隆, 長尾 吉泰, 森 健策, 前原 喜彦, 橋爪 誠

    第67回日本消化器外科学会総会  2012.7 

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    Event date: 2012.7

    Language:Others  

    Venue:富山   Country:Japan  

  • PSE(partial splenic arterial embolization)無効例にに対する腹腔鏡下脾臓摘出術の有用性の検討

    橋本 直隆, 長尾 吉泰, 森田 和豊, 増田 稔朗, 赤星朋比古, 池上 徹, 吉住 朋晴, 富川 盛雅, 調 憲, 前原 喜彦

    第37回日本外科系連合学会学術集会  2012.6 

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    Event date: 2012.6

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    Venue:福岡   Country:Japan  

  • 止血・組織修復に対する手術手技 腹腔鏡下脾臓摘出術における術後合併症予防の工夫

    堤 敬文, 山口 将平, 赤星 朋比古, 長尾 吉泰, 家守 雅大, 楠元 英次, 櫻井 眞人, 遠藤 和也, 池尻 公二, 橋爪 誠, 前原 喜彦

    第37回日本外科系連合学会学術集会  2012.6 

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    Language:Japanese  

    Venue:福岡   Country:Japan  

  • Novel portal vein pressure monitoring method for patient with portal hypertension using computational fluid dynamics. International conference

    Yasuhiro Nagao, Munenori Uemura, Tomohiko Akahoshi, MORIMASA TOMIKAWA, Makoto Hashizume

    CARS 2012 - Computer Assisted Radiology and Surgery  2012.6 

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    Event date: 2012.6

    Language:English  

    Country:Italy  

  • 門脈圧亢進症 肝性脳症に対するバルーン閉塞下逆行性経静脈的塞栓術とその治療成績の向上を目指した新たな工夫

    富川 盛雅, 赤星 朋比古, 橋本 直隆, 長尾 吉泰, 前原 喜彦, 橋爪 誠

    第48回日本肝臓学会総会  2012.6 

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    Event date: 2012.6

    Language:Japanese  

    Venue:金沢   Country:Japan  

  • 腹腔鏡脾臓摘出術のLatest modern technique

    赤星朋比古, 富川盛雅, 橋本直隆, 家守雅大, 長尾吉泰, 調 憲, 橋爪 誠, 前原喜彦

    第66回 日本手術手技研究会  2012.5 

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    Event date: 2012.5

    Language:Others  

    Venue:福岡   Country:Japan  

  • Endoscopic management of esophago-gastric variceal bleeding The Impact of Balloon-occluded Retrograde Transvenous Obliteration on Management of Gastric Variceal Bleeding International conference

    Tomohiko Akahoshi, Makoto Hashizume, Yoshihiko Maehara

    2012.5 

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    Language:Others  

    Country:Japan  

  • 胆汁鬱帯性肝硬変症の食道静脈瘤に対する予防的EVLの適応限界に関する検討 International conference

    橋本 直隆, 赤星朋比古, 富川 盛雅, 長尾 吉泰, 家守 雅大, 森田 和豊, 萱島 寛人, 池上 徹, 吉住 朋晴, 調 憲, 前原 喜彦

    第83回日本消化器内視鏡学会総会  2012.5 

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    Event date: 2012.5

    Language:Others  

    Venue:東京   Country:Japan  

  • 単孔式鼠径ヘルニア修復術に対するドーム型立体映像表示システムの有用性

    富川 盛雅, 長尾吉泰, 植村 宗則, 吉田正樹, 堀 淳一, 石井裕之, 大内田 研宙, 赤星 朋比古, 家入 里志, 大平 猛, 橋爪 誠

    第10回日本ヘルニア学会学術集会  2012.4 

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    Event date: 2012.4

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • ハイパースペクトル内視鏡を用いた大腸腫瘍性病変における酸素飽和度の可視化

    神代 竜一, 赤星 朋比古, 長尾 吉泰, 安藤 幸滋, 佐伯 浩司, 沖 英次, 大賀 丈史, 富川 盛雅, 掛地 吉弘, 前原 喜彦, 橋爪 誠

    第112回日本外科学会定期学術集会  2012.4 

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    Event date: 2012.4

    Language:Japanese  

    Venue:千葉   Country:Japan  

  • Natural Orifice Translumenal Endoscopic Surgeryを想定した脾摘術の意義と新しい先端医療機器開発への取り組み

    富川 盛雅, 赤星 朋比古, 堤 敬文, 長尾 吉泰, 家守 雅大, 神代 竜一, 橋本 直隆, 大内田 研宙, 家入 里志, 大平 猛, 前原 喜彦, 橋爪 誠

    第112回日本外科学会定期学術集会  2012.4 

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    Event date: 2012.4

    Language:Japanese  

    Venue:千葉   Country:Japan  

  • 腹腔鏡下脾摘術におけるフィブリン糊+ポリグリコール酸シートを用いた術後合併症予防法

    堤 敬文, 山口 将平, 富川 盛雅, 赤星 朋比古, 長尾 吉泰, 家守 雅大, 楠元 英次, 櫻井 眞人, 遠藤 和也, 橋爪 誠, 前原 喜彦, 池尻 公二

    第112回日本外科学会定期学術集会  2012.4 

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    Event date: 2012.4

    Language:Japanese  

    Venue:千葉   Country:Japan  

  • 胃静脈瘤出血例に対するBalloon-occluded retrograde transvenous obliterationの意義

    赤星朋比古, 富川盛雅, 長尾吉泰, 橋爪 誠, 前原喜彦

    第48回日本腹部救急医学会総会  2012.3 

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    Event date: 2012.3

    Language:Others   Presentation type:Oral presentation (general)  

    Venue:石川   Country:Japan  

  • Rigid and flexible endoscopic rendezvous in spatium peritonealis may be an effective tactic for laparoscopic megasplenectomy: significant implications for pure NOTES. International conference

    MORIMASA TOMIKAWA, Tomohiko Akahoshi, Yoshihiro Nagao, Makoto Hashizume

    SAGES  2012.3 

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    Event date: 2012.3

    Language:English  

    Country:United States  

  • 再発性鼠径ヘルニアに対し、ComposixTM EX Meshを用い腹腔鏡下修復術を行なった一例

    長尾 吉泰, 赤星 朋比古, 富川 盛雅, 橋爪 誠

    第6回九州ヘルニア研究会  2012.2 

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    Event date: 2012.2

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • Acute care surgeryにおける消化器外科医の関わりにおける諸問題と対策

    赤星 朋比古, 永田 高志, 杉森 宏, 橋爪 誠

    第39回日本救急医学会総会・学術集会  2011.10 

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    Event date: 2011.10

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 腹腔鏡下脾臓摘出術のlatest modern technique

    赤星 朋比古, 富川 盛雅, 堤 敬文, 長尾 吉泰, 家守 雄大, 調 憲, 橋爪 誠, 前原 喜彦

    第21回九州内視鏡下外科手術研究会  2011.9 

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    Event date: 2011.9

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • Laparoscopic splenectomy in one hundred HCV-cirrhosis patients with hypersplenisum and thrombocytopenia International conference

    Tomohiko Akahoshi, MORIMASA TOMIKAWA, Yoshihiko Maehara

    International Surgical Week 2011  2011.8 

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    Event date: 2011.8

    Language:English  

    Country:Japan  

  • A laparoendoscopic redezvous in spatium peritonealis on medasplenectomy for cirrhotic patients with slim chance: a feasibility study International conference

    MORIMASA TOMIKAWA, Tomohiko Akahoshi, Kinjyo N, Yoshihiro Nagao, Naotaka Hashimoto, Uehara H, Makoto Hashizume

    International Surgical Week 2011  2011.8 

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    Event date: 2011.8

    Language:English  

    Country:Japan  

  • 治療内視鏡の有効性評価:得られたエビデンスと今後の展望食道・胃静脈瘤硬化療法の治療と変遷

    赤星 朋比古, 富川 盛雅, 堤 敬文, 長尾 吉泰, 家守 雄大, 橋爪 誠, 前原 喜彦

    第81回日本消化器内視鏡学会総会  2011.8 

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    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 消化器外科医に求められる救急医療の教育プログラム―救急医療における外科医の関わりにおける諸問題と対策

    赤星 朋比古, 永田 高志, 橋爪 誠

    第66回日本消化器外科学会総会  2011.7 

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    Event date: 2011.7

    Language:Japanese  

    Venue:名古屋   Country:Japan  

    近年消化器外科医は、専門分化され、外傷診療を担える外科医は減りつつある。よって重症外傷に伴う腹部臓器損傷に対して無力となっており、助けれるはずの患者を救命できない現状が存在する。その問題点と方策について検討した。

  • 難治性静脈瘤に対する腹腔鏡下Hassab手術

    赤星 朋比古, 富川 盛雅, 堤 敬文, 長尾 吉泰, 家守 雄大

    第47回日本腹部救急医学会総会  2011.3 

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    Event date: 2011.3

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • The major role of COX-1 in increased portal vein pressure of portal hypertensive rats. International conference

    American association for the study of liver disease meeting (Digestive disease week)  2004.5 

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    Country:United States  

  • Are selective COX-1 or COX-2 NSAIDs injurious to the portal hypertensive gastric mucosa? To what extent and why? International conference

    Portal hyper tension in the 21th Century  2004.4 

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    Country:Canada  

  • COVID-19重症肺炎を合併した妊婦に対して腹臥位療法を行った1例

    畠山 究, 徳田 賢太郎, 安藤 太一, 高橋 慶多, 十時 崇彰, 彌永 武史, 西原 正章, 生野 雄二, 牧 盾, 赤星 朋比古

    日本集中治療医学会雑誌  2022.11  (一社)日本集中治療医学会

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  • 高度肥満の敗血症患者に対するICUでの早期離床が奏功した一例

    奈須 勇樹, 根津 智之, 草葉 隆一, 川口 謙一, 桑門 想, 山本 悠造, 徳田 賢太郎, 赤星 朋比古

    理学療法福岡  2022.2  (公社)福岡県理学療法士会

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  • 高エネルギー外傷患者における集中治療と逸脱酵素との関連についての検討

    崎村 正太郎, 大屋 皆既, 高森 信乃介, 高橋 慶多, 大澤 さやか, 牧 盾, 徳田 賢太郎, 赤星 朋比古, 山浦 健

    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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  • 骨盤骨折治療に併用した持続局所抗菌薬灌流(CLAP)の治療成績

    籾井 健太, 赤星 朋比古

    日本外傷学会雑誌  2022.6  (一社)日本外傷学会

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  • 頭部外傷を合併した胸椎脱臼骨折に対する脊椎固定術後に頭蓋内血腫が増大した1例

    河野 通仁, 籾井 健太, 木原 大護, 田丸 哲弥, 牧 盾, 小早川 和, 川口 謙一, 赤星 朋比古, 中島 康晴

    整形外科と災害外科  2022.5  西日本整形・災害外科学会

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  • 院外心停止に対するECPRにおける経食道心エコーの有用性についての検討

    高橋 慶多, 高森 信之介, 大屋 皆既, 崎村 正太郎, 畠山 究, 彌永 武史, 西原 正章, 赤星 朋比古, 牧 盾, 山浦 健

    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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  • 脂肪塞栓症候群に合併した循環不全に一酸化窒素吸入が奏功した一例

    陣林 秀紀, 畠山 究, 籾井 健太, 吉本 将和, 桑原 正成, 彌永 武史, 西原 正章, 生野 雄二, 牧 盾, 中島 康晴, 赤星 朋比古

    日本救急医学会雑誌  2022.10  (一社)日本救急医学会

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    日本外科学会定期学術集会抄録集  2023.4  (一社)日本外科学会

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    日本集中治療医学会雑誌  2022.11  (一社)日本集中治療医学会

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    理学療法福岡  2022.2  (公社)福岡県理学療法士会

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  • 高エネルギー外傷患者における集中治療と逸脱酵素との関連についての検討

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    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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    籾井 健太, 赤星 朋比古

    日本外傷学会雑誌  2022.6  (一社)日本外傷学会

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  • 頭部外傷を合併した胸椎脱臼骨折に対する脊椎固定術後に頭蓋内血腫が増大した1例

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    整形外科と災害外科  2022.5  西日本整形・災害外科学会

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    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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  • 門脈圧亢進症の治療 門脈血行異常症における診療ネットワーク構築

    赤星 朋比古, 大藤 さとこ, 橋爪 誠, 鹿毛 政義

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    日本救急医学会雑誌  2022.10  (一社)日本救急医学会

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  • 病的骨折に対する髄内釘とプレートを併用した治療成績

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    整形外科と災害外科  2023.10  西日本整形・災害外科学会

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  • 災害と医療~病院としての災害への備え 災害にそなえる病院BCPの作成とそのあり方について

    赤星 朋比古

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  • 減量・代謝改善手術ネクストステージ 減量・代謝改善手術の対象患者における,新規肝機能推定装置の開発

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    日本外科学会定期学術集会抄録集  2023.4  (一社)日本外科学会

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  • 気胸を合併したCOVID-19重症肺炎の臨床的特徴についての検討

    山本 悠造, 畠山 究, 彌永 武史, 西原 正章, 生野 雄二, 賀来 典之, 牧 盾, 徳田 賢太郎, 赤星 朋比古, 北園 孝成

    日本集中治療医学会雑誌  2022.11  (一社)日本集中治療医学会

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  • 最新内視鏡外科ガイドラインのポイント-「知」なしで内視鏡外科手術を行うべからず- 内視鏡外科ガイドライン2023版 膵・脾部門

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    日本内視鏡外科学会雑誌  2023.12  (一社)日本内視鏡外科学会

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  • 心停止蘇生後患者における心停止原因別の体温管理療法と神経学的転帰の関連についての検討

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    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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  • 循環器救急医療入院患者における新規発症心房細動または心房粗動の実態調査(JROAD-DPC研究)

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    日本救急医学会雑誌  2023.12  (一社)日本救急医学会

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  • 小児救急症例対応高機能シミュレータを用いた医学部学生への教育効果

    白澤 彩, 賀来 典之, 赤星 朋比古

    日本小児科学会雑誌  2024.2  (公社)日本小児科学会

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  • 多診療科合同の腹部救急領域疾患に対する教育体制 重症体幹部外傷における多診療科連携 当院でのこれまでの取り組み・成果と問題点

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  • 冠血流異常がないにも関わらず、対側性変化を伴うST上昇を呈し、STEMIとの鑑別を要した気腫性腎盂腎炎の一例

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    日本救急医学会雑誌  2023.12  (一社)日本救急医学会

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    日本消化器外科学会総会  2022.7  (一社)日本消化器外科学会

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    日本DDS学会学術集会プログラム予稿集  2023.7  日本DDS学会

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    日本救急医学会雑誌  2023.12  (一社)日本救急医学会

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    日本集中治療医学会雑誌  2022.11  (一社)日本集中治療医学会

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MISC

  • Electromagnetic thermoablation to treat thrombocytopenia in cirrhotic and hypersplenic rats. J Gastroenterol Hepatol

    Akahoshi T. Hashizume M

    2011.7

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  • 脾臓摘出術ー安全確実な手術を行うための工夫

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    2009.7

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  • 【一次救急における初期対応】救急医療の現場と課題

    赤星 朋比古

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    赤星 朋比古

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  • 【一次救急における初期対応】救急医療の現場と課題

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  • 【抗菌薬の理解と臨床】抗菌薬とアレルギー

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    腸内フローラシンポジウム   30   19 - 32   2023.9

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  • 【早わかり消化器内視鏡関連ガイドライン2023】消化器全般におよぶもの 門脈血行異常症ガイドライン

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    消化器内視鏡   35 ( 9 )   1295 - 1302   2023.9   ISSN:0915-3217

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  • 頭部外傷を合併した胸椎脱臼骨折に対する脊椎固定術後に頭蓋内血腫が増大した1例

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    researchmap

  • 術後膵液瘻に関する迅速診断を目的としたForster resonance energy transfer(FRET)標識ナノプローブの開発

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    日本外科学会定期学術集会抄録集   2018.4

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  • THE PRESEPSIN LEVEL ON ICU ADMISSION IS A MARKER OF THE SEVERITY OF ICU PATIENTS

    Kentaro Tokuda, Jun Maki, Noriyuki Kaku, Soichi Mizuguchi, Mitsuhiro Fukata, Tomohiko Akahoshi, Sumio Hoka, Yoshihiko Maehara

    CRITICAL CARE MEDICINE   2016.12

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  • 一本の経皮的な経路が経口内視鏡操作を安全で有効な治療に変える、胆道Rendezvous Techniqueの基本と応用

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    2015.4

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  • 肝葉切除術に対する完全腹腔鏡下切除の功罪 肝葉切除術に対する完全腹腔鏡下切除の利点と課題

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    日本内視鏡外科学会雑誌   2014.10

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  • 異常側副血行路に対するIVR治療の方法と成績 B-RTOにおけるHVPG変化率の意義

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    日本門脈圧亢進症学会雑誌   2014.8

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  • 腹腔鏡下腹壁ヘルニア修復術の手技の工夫と治療成績

    川中 博文, 赤星 朋比古, 伊藤 心二, 日吉 幸晴, 山下 洋市, 池上 徹, 杉町 圭史, 佐伯 浩司, 内山 秀昭, 沖 英次, 吉住 朋晴, 副島 雄二, 三森 功士, 渡邊 雅之, 富川 盛雅, 森田 勝, 調 憲, 池田 哲夫, 是永 大輔, 竹中 賢治, 前原 喜彦

    臨牀と研究   2013.12

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    2005年から2013年8月までに行った腹腔鏡下腹壁ヘルニア修復術65例を対象とし、再発や合併症を低減するための手技の工夫とその治療成績を報告した。当科では、腹壁ヘルニアの治療の基本はメッシュを用いた腹腔鏡下修復術と考え、ポート挿入位置、癒着剥離、メッシュのサイズの決定と固定部位のマーキング、メッシュの固定、seromaの予防、術後などの手技を工夫している。自験例では平均ヘルニア門長径8.3cm、平均手術時間177分、平均出血量23g、平均術後入院日数12.1日で開腹移行は4例(6.2&#37;)であった。合併症は遅発性腸管損傷1例(1.5&#37;)で、メッシュ感染やメッシュの癒着に伴う腸管瘻はなく、再発は傍ストーマヘルニアの1例(1.5&#37;)のみで平均観察期間は2年であった。腹腔鏡下腹壁ヘルニア修復術は腹壁ヘルニア治療の第一選択になり得ると考えられた。

  • 慢性C型肝炎/肝硬変患者における脾摘後の門脈血行動態と肝機能改善に関する検討

    金城 直, 川中 博文, 赤星 朋比古, 長尾 吉泰, 家守 雅大, 橋本 直隆, 上原 英雄, 富川 盛雅, 山下 洋市, 内山 秀昭, 佐伯 浩司, 森田 勝, 杉町 圭史, 三森 功士, 渡邉 雅之, 調 憲, 池田 哲夫, 橋爪 誠, 前原 喜彦

    臨牀と研究   2013.12

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    脾摘術または腹腔鏡下脾摘術を行った慢性C型肝炎/肝硬変患者36人について、脾摘前後の肝機能と門脈血行動態の変化を調査し、脾摘の意義を検討した。平均脾重量396g、平均白血球数3,945/μl、Child Pugh分類はA 16例、B 19例、C 1例、術前の肝静脈波型はI型18例、II型18例であり、術前、術後6ヵ月、1年の肝機能検査値、肝硬変の重症度診断、ならびに術前、術後7日目の門脈血流量や血流速度、肝静脈波型を評価した。その結果、慢性C型肝炎/肝硬変患者では脾摘後に門脈血流量や血流速度が低下しており、肝静脈波型がII型からI型に改善した14例では肝機能の改善がみられた。今回、脾摘による門脈血流量および門脈血流速度の低下が肝機能改善に関与している可能性が示唆され、肝静脈波型の変化によって脾摘後の肝機能改善に違いがあることが明らかとなった。

  • 鼠径部ヘルニアに対する腹膜の解剖を意識したtotally extra-peritoneal pre-peritoneal repair(TEPP)法の実際

    川中 博文, 赤星 朋比古, 山下 洋市, 池上 徹, 杉町 圭史, 佐伯 浩司, 内山 秀昭, 沖 英次, 吉住 朋晴, 副島 雄二, 三森 功士, 渡邊 雅之, 森田 勝, 調 憲, 池田 哲夫, 前原 喜彦

    臨牀と研究   2013.11

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  • 特集 災害時の経口補水療法 災害時における脱水・低栄養回避―感染症アウトブレイク対策.

    赤星 朋比古, 橋爪 誠

    2013.9

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    Language:Japanese  

  • 医用画像に基づく計算解剖学の消化器外科領域への応用

    赤星 朋比古, 富川 盛雅, 橋爪 誠

    2013.7

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    Language:Japanese  

  • 肝硬変症における肝脾相関ー脾臓摘出術, 部分的脾動脈塞栓術の視点からー

    赤星朋比古, 橋爪誠

    2012.10

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    Language:Japanese  

  • 消化器疾患の医療ニーズ バッドキアリ症候群

    赤星朋比古, 橋爪誠

    2012.10

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    Language:Others  

  • 特集 ; 外科医が知っておきたい救急処置 : S-Bチューブ挿入

    赤星朋比古, 神代竜一, 富川盛雅, 橋爪誠

    2012.9

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  • 〔治療ー内視鏡治療の最先端〕食道・胃静脈瘤に対する内視鏡治療の現状

    赤星朋比古, 橋本直隆, 家守雄大, 長尾吉泰, 富川盛雅, 前原喜彦, 橋爪誠

    2011.12

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  • 門脈圧亢進症患者に対する腹腔鏡下脾臓摘出術

    赤星朋比古, 富川盛雅, 川中博文, 前原喜彦, 橋爪誠

    2011.9

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  • 巨大肝嚢胞に対するエタノール硬化療法併用腹腔鏡下肝嚢胞開窓術

    赤星朋比古, 矢加部 茂, 江見 泰徳, 池尻 公二, 才津 秀樹

    2008.8

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  • バッドキアリ症候群の重症度分類と新治療指針

    3. 赤星朋比古, 橋爪 誠

    2003.9

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  • 手術支援ロボテイックシステムの現状と問題点

    赤星朋比古, 橋爪誠, 金城 直, 小西晃造, 村垣善浩

    2002.10

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  • 腹腔鏡下脾臓摘出術.消化器外科

    赤星朋比古, 橋爪 誠

    2002.8

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  • 血液疾患に対する腹腔鏡下脾臓摘出術

    赤星朋比古, 橋爪 誠, 杉町圭蔵

    2001.6

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  • 食道静脈瘤に対する硬化療法とEVL

    赤星朋比古, 橋爪誠, 森田真, 田上和夫, 漢那朝雄, 杉町圭蔵

    1999.10

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    Language:Japanese  

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Professional Memberships

  • Japanese Association for Acute Medicine

    2010.4 - Present

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  • 日本集中治療医学会

    2014.4 - Present

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  • Japanese Association for sugery

    1997.5 - Present

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  • 日本肝臓学会

  • 日本門脈圧亢進症学会

  • 日本再生医療学会

  • 日本消化器外科学会

  • Japanese Association for sugery

  • 日本集中治療医学会

  • Japanese Association for Acute Medicine

  • 日本コンピュータ外科学会

  • 日本消化器内視鏡学会

  • 日本炎症・再生医学会

  • 日本門脈圧亢進症学会

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  • 日本肝臓学会

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  • 日本炎症・再生医学会

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  • 日本消化器外科学会

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  • 日本消化器内視鏡学会

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  • 日本コンピュータ外科学会

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Committee Memberships

  • 九州大学   心肺蘇生サポート委員会 委員長  

    2020.7 - 2022.4   

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    Committee type:Other

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  • 日本外科学会   臨床研究推進委員会 救急医学部門  

    2020.4 - Present   

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    Committee type:Academic society

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  • Councilor   Domestic

    2014.1 - 2019.1   

  • Councilor   Domestic

    2010.1 - 2015.1   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:5

    Number of peer-reviewed articles in Japanese journals:5

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

    Number of peer-reviewed articles in Japanese journals:4

  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:5

    Number of peer-reviewed articles in Japanese journals:4

  • 座長(Chairmanship)

    第113回日本外科学会定期学術集会  ( 福岡国際会議場 ) 2013.4

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第49回日本腹部救急医学会  ( 福岡 ) 2013.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第18回日本門脈圧亢進症学会総会  ( 福岡 ) 2011.9

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    Type:Competition, symposium, etc. 

  • 事務局

    九州内視鏡外科研究会  ( 沖縄コンベンションセンター ) 2010.9

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 座長(Chairmanship)

    第19回九州内視鏡下外科手術研究会  ( 大分コンパルホール ) 2009.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第18回九州内視鏡下外科手術研究会  ( 熊本県民交流会館パレア ) 2008.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( パシフィコ横浜 ) 2008.9

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    Type:Competition, symposium, etc. 

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Research Projects

  • Inflammasome-Responsive Nanomedicine for treatment of acute respiratory distress syndrome (ARDS)

    Grant number:24K21342  2024.6 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Pioneering)

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    Grant type:Scientific research funding

    CiNii Research

  • Development of education, transport, and centralization models for pediatric ECMO cases.

    Grant number:24K13391  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

    CiNii Research

  • 臨床エビデンスに基づくミトコンドリア代謝高感度診断法の開発

    Grant number:23K27312  2023.4 - 2027.3

    科学研究費助成事業  基盤研究(B)

    兵藤 文紀, 新井 泰央, 赤星 朋比古, 松尾 政之, 森 崇, 富田 弘之

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    Grant type:Scientific research funding

    エネルギー合成や脂質代謝を担うミトコンドリアは様々な疾患に深く関与しており、申請者は 目(形態)では判断できない異常をミトコンドリア機能で診る新たな機能診断技術の開発を目的として研究を進めている。本研究では、高精度で臨床応用可能な新たなミトコンドリア代謝情報に基づく新たな高感度診断法を開発する。

    CiNii Research

  • ICU患者におけるせん妄発症に関連した口腔状態の危険因子の解明

    Grant number:23K09506  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    神野 哲平, 赤星 朋比古, 和田 尚久

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    Grant type:Scientific research funding

    せん妄は ICU 患者の予後不良因子の 1つとして知られている。ICUでのせん妄発症は、ICU在室日数および入院期間の延長、医療費の増大、死亡率の上昇、ICU 退室後も続く認知機能の低下などに関連するため、患者のせん妄発症リスクから発症予測を行うことは、重要な視点となりうる。本研究では、せん妄発症に関連する口腔状態の危険因子を解明する。予備研究において、舌細菌数がせん妄の発症予測因子であることが示唆されており、口腔細菌叢とせん妄との関連性についても解析を行う。ICU患者の早期回復と退院後のQOLの向上へ、口腔から始める新たなせん妄対策を提案することを目指す。

    CiNii Research

  • The effecacy of phosphasil serine nanocareer for acute respiratory distress syndrome

    Grant number:23K24434  2022.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant type:Scientific research funding

    CiNii Research

  • 急性肝不全に対する硫化水素キノン酸化還元酵素(SQOR)の効果の検討

    Grant number:22K09097  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    白水 和宏, 赤星 朋比古

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    Grant type:Scientific research funding

    ・急性肝不全は未だに難治性の病態である。近年ウイルス性肝炎からの急性肝不全を発症する患者は減少傾向である一方、自己免疫性急性肝炎、非アルコール性脂肪肝炎が増加傾向にある。
    ・Concanavalin A(Con A)によって自己免疫性急性肝炎に類似した病態を誘発することができる。
    ・本申請研究では、Con Aによって引き起こされる急性肝不全モデルに対するSQORの効果を検証する。アデノ随伴ウイルスベクター (AAV)は肝臓に集積することが以前より広く知られており、SQORの過剰発現マウスを作成し、AAV-GFP(コントロール)とAAV-GFP-SQOR(過剰発現)の2群により検討する。

    CiNii Research

  • ホスファチジルセリンナノキャリアを用いた急性呼吸促拍症候群に対する治療法の開発

    Grant number:22H03175  2022 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • Development of cell signal-responsive contrast agent for diagnosis of NASH

    Grant number:21K18325  2021.7 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Pioneering)

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    Grant type:Scientific research funding

    CiNii Research

  • 重篤小児患者の筋力低下の実態とリスク因子の解明

    Grant number:21K11215  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    松岡 若利, 賀来 典之, 赤星 朋比古, 鉄原 健一

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    Grant type:Scientific research funding

    小児の集中治療後に持続する運動機能障害は、小児の集中治療後症候群(PICS-p:postintensive care syndrome - pediatrics)の重要な要素である。しかし、PICS-pの実態は十分には把握されておらず、従ってリハビリテーションの効果も定まっていない。本研究は、重篤小児患者における小児集中治療室(PICU:pediatric intensive care unit)入室後の運動機能障害の実態とそのリスク因子の把握を行うことを第一とする。その上でリハビリテーションが重篤小児患者において身体的な長期機能予後の改善に結びつくかどうかを検討する。

    CiNii Research

  • Mitochondrial protection in cardiomyocytes by thiosulfate

    Grant number:20K09198  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    TOKUDA Kentaro

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    Grant type:Scientific research funding

    Doxorubicin (DOX) induces cardiac toxicity predominantly due to reactive oxygen species (ROS)-mediated oxidative stress. Previously, we have shown that sodium thiosulfate attenuates DOX-induced cardiotoxicity by suppressing oxidative stress. Based on the finings, we would try to validate the hypothesis if sodium thiosulfate could protect hearts mainly by preserving mitochondrial function in cardiomyocytes. We applied a novel imaging assay Dynamic Nuclear Polirization(DNP)-MRI, which visualizes the redox status in hearts. DNP-MRI revealed that DOX decreased the reduction rates of redox probe in hearts compared to the control. However, it was not shown that sodium thiosulfate attenuated reducing mitochondrial dysfunction in the DOX-induced cardiac dysfunction model. Further research would be needed to solve the hypothesis.

    CiNii Research

  • Development of innovative surgical education program beyond point of technical view

    Grant number:20K12693  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Tomikawa Morimasa

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    Grant type:Scientific research funding

    The Kyushu University Training Center for Minimally Invasive Surgery has been regularly held minimally invasive surgery training programs for more than 18 years. In a comparative study of the participants who later obtained certification of endoscopic surgical skill qualification system and those who did not, the qualified surgeons had fewer years of post-graduation and scored higher on accuracy than on speed in the post-training evaluation 1), and admitted multiple participants from the same institution 2).
    It may be possible to set training programs suitable for each individual by clarifying these characteristics.
    In order to pass on endoscopic surgical techniques, it is necessary to stabilize forceps movement as an individual through Box training from the early stage of post-graduation, and it is also necessary to standardize the technique at each institution.

    CiNii Research

  • The effectiveness of remote training with ABC approach simulation in pediatric emergency cases for nurses.

    Grant number:20K10832  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KAKU NORIYUKI

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    Nurses rather than pediatricians encounter most of the in-hospital pediatric emergency cases at first. In this study, we performed simulation-based medical education of pediatric emergency cases for nurses. The remote education using teleconference session on the Internet was performed for the participant to become able to receive practical training from a facilitator in the distant place. To evaluate the effectiveness of the education, we performed the simulation test of the pediatric respiratory emergency case before and after simulation-based education. We assessed the each factor of ABCDE approach (A: Airway, B: Breathing, C: Circulation, D: Dysfunction of CNS, E: Exposure) to evaluate the performance objectively. There was not the difference between remote and direct group, and the efficacy of the in-hospital remote simulation-based education was shown. Whereas enough achievement was not obtained, and the remote control of the inter-facility simulation became the future problem.

    CiNii Research

  • Investigating the Effects of Farnesylation on an Autoimmune Hepatitis Model

    Grant number:19K09374  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Shirozu Kazuhiro

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    A mouse model of acute liver failure was created to demonstrate that the farnesyltransferase inhibitor studied as a therapeutic agent had a protective effect. Specifically, the study demonstrated that the inhibitor suppressed the elevation of liver enzymes caused by acute liver failure, suppressed the areas of necrosis in liver tissue, and suppressed the elevation of pro-inflammatory cytokines. As the mechanism of the inhibition, we proved that it inhibits the secretion of IFN-γ from CD4 Tcells by inhibiting the phosphorylation of STAT1 via CD4 Tcells.

    CiNii Research

  • Identification of the relationship and its mechanism between cardiac arrest and underlying sarcopenia

    Grant number:17K11577  2017.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Mitsuhiro Fukata

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    In patients with non-traumatic cardiac arrest, the presence of sarcopenia, as estimated by skeletal muscle area, was significantly associated with survival at 24 hours. In patients with atrial fibrillation who underwent catheter ablation, pectoral muscle area/body surface area was associated with an increased rate of the recurrence of atrial fibrillation in women. Serum myokine was measured in patients with atrial fibrillation, and somatomedin C was significantly correlated with 5m walking speed, but age was considered a confounding factor; Myostatin was significantly associated with 5m walking speed after age correction and may be useful as a marker of sarcopenia in patients with cardiac disease.

    CiNii Research

  • 肝内微小循環改善と脾機能制御による肝硬変症に対する革新的集学的治療法の確立

    2015.4 - 2016.3

    共同研究

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    Authorship:Coinvestigator(s)  Grant type:Other funds from industry-academia collaboration

  • 腹腔鏡下超音波検査を簡単操作に変える手首運動を再現した遠隔回転中心を有する多自由度自在電動アームの開発

    2014.6 - 2015.6

    共同研究

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    Authorship:Coinvestigator(s)  Grant type:Other funds from industry-academia collaboration

  • 皮下脂肪由来間葉系幹細胞による肝硬変に対する革新的治療法の開発

    2014.4 - 2016.3

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    Authorship:Principal investigator 

    現在、治療法のない肝硬変に対して、比較的採取しやすい脂肪由来間葉系幹細胞をもちいて治療することを目的とする。臨床での応用を目指してまずはラット肝硬変での実験を行っている。

  • 自己皮下脂肪由来間葉系幹細胞を用いた肝硬変症に対する革新的治療法の開発

    Grant number:25462096  2013 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 自己皮下脂肪由来間葉系幹細胞を用いた肝硬変症に対する革新的治療法の開発

    2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 肝硬変における肝微小循環の改善

    2009.5 - 2011.5

    日本 

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  • 肝硬変症における肝内微小循環障害の分子機序の解明と肝機能改善のための治療法の開発

    Grant number:21591755  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 「門脈圧亢進症におけるシグナルトランスダクションの研究」

    2004 - 2005

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Class subject

  • 救急医療

    2021.4 - 2022.3   Full year

  • 感染症・中毒

    2021.4 - 2021.9   First semester

  • 救急医学総論、災害救急医学

    2013.4 - 2014.3   Full year

  • 意識障害とショック

    2013.4 - 2014.3   Full year

  • 医学部1年 コアセミナー災害救急医学

    2013.4 - 2013.9   First semester

  • 医学部1年 医学生命科 コアセミナー

    2010.4 - 2010.9   First semester

  • 外科 縫合結紮講習

    2010.4 - 2010.9   First semester

  • 脾門脈分野

    2008.4 - 2008.9   First semester

  • 脾門脈分野

    2008.4 - 2008.9   First semester

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Participation in international educational events, etc.

  • 2018.7

    九州大学決断科学プログラム

    The 2nd International symposium on decision science for future earth

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    Venue:Fukuoka, Japan

    Number of participants:200

Other educational activity and Special note

  • 2023  Coaching of Students' Association 

  • 2018  Coaching of Students' Association 

Outline of Social Contribution and International Cooperation activities

  • 平成23年度より、九州大学における外傷初期診療コース(年2回開催)の講師および外傷手術トレーニングコース(ATOMコース)(年2回)においての実行のスタッフおよび講師として、他大学の医師、研修医を対象に教育をおこなっている。
    また、内視鏡手術トレーニングコースのインストラクターとして月に2回のドライラボおよびウェットラボでの内視鏡外科手術トレーニングを開催している。

Social Activities

  • Heat shock

    Role(s): Appearance, Lecturer, Informant

    2022.12

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    Type:TV or radio program

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  • 福岡あん・あん塾

    福岡市  福岡市防災会館  2021.10

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

    福岡市民を対象に毎年、災害の基礎知識、救命処置、災害時の医療等についての講演会

  • 九州支援団として北部九州豪雨災害の被災地において九州大学の学生とともに避難所での支援活動を行う。

    2017

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    九州支援団として北部九州豪雨災害の被災地において九州大学の学生とともに避難所での支援活動を行う。

  • 九州支援団として北部九州豪雨災害の被災地において九州大学の学生とともに避難所での支援活動を行う。

    2017

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    Type:Other

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  • とっても健康ランド 「熱中症」

    KBCテレビ  2016.7

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:TV or radio program

  • ときめきサイエンス  これからの外科はどうなるの?

    文部科学省  2016.7

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • ときめきサイエンス これからの外科はどうなるの?

    文部科学省  2016.7

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    Type:Seminar, workshop

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  • とっても健康ランド 「熱中症」

    KBCテレビ  2016.7

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    Type:TV or radio program

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  • 世の中のしくみがわかる本 (小学館)

    2008.9

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Other

  • 世の中のしくみがわかる本 (小学館)

    2008.9

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    Type:Other

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Media Coverage

  • 平成6年能登地震 災害関連死の予防 クラッシュ症候群、エコノミークラス症候群、低体温症にていてその予防と対策について解説 Newspaper, magazine

    西日本新聞  2022.1

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    平成6年能登地震 災害関連死の予防
    クラッシュ症候群、エコノミークラス症候群、低体温症にていてその予防と対策について解説

  • 北部豪雨災害 における熱中症およびエコノミークラス症候群 対策 TV or radio program

    NHK  2017.8

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    北部豪雨災害 における熱中症およびエコノミークラス症候群 対策

Educational Activities for Highly-Specialized Professionals in Other Countries

  • 2002.4 - 2003.4   海外派遣留学生の基礎研究従事 「門脈圧亢進症胃粘膜におけるNOとエストロゲンの発言の意義についての検討」

    Main countries of student/trainee affiliation:China

Specialized clinical area

  • Comprehensive and New Fields / Comprehensive Fields / Informatics / Fundamentals of Informatics

    コンピュータ外科学、内視鏡学

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / General Surgery

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Emergency Medicine

    腹部救急医学, 救急医学、災害救急医学、外傷外科学、門脈圧亢進症

Clinician qualification

  • Specialist

    The Japan Society of Hepatology(JSH)

  • Preceptor

    Japan Surgical Society(JSS)

  • Preceptor

    The Japanese Society of Gastroenterological Surgery

  • Preceptor

    Japan Gastroenterological Endoscopy Society(JGES)

  • Preceptor

    Japanese Association for Acute Medicine(JAAM)

  • Preceptor

    日本消化器外科学会、日本肝臓学会、日本門脈圧亢進症学会

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Year of medical license acquisition

  • 1995

Notable Clinical Activities

  • 門脈血行異常症の成因と治療に関する研究 ,急性期外傷診療(JATEC) 腹腔鏡下脾臓摘出術、Acute care surgery 厚生労働省 門脈血行異常症調査研究班 研究協力者 大学病院におけるBCP作成 WG長 院内ドナーコーディネート委員会 委員長