記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 1007/s00464-012-2737

DOI： 10.1111/j.1872-034X.2011.00939.x. Epub 2011 Dec 19.PMID:22176386

記述言語：英語  

Laparoscopic splenectomy with peginterferon and ribavirin therapy for patients with hepatitis C virus cirrhosis and hypersplenism.

記述言語：英語  

記述言語：英語  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1046/j.1440-1746.2002.02667.x

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1067/msy.2002.119501

記述言語：英語   出版者・発行元：Asian Journal of Endoscopic Surgery  

DOI： 10.1111/ases.13370

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記述言語：英語   出版者・発行元：Journal of Intensive Care  

Background: Sympathetic nerve activity (SNA) plays a central role in the pathogenesis of several diseases such as sepsis and chronic kidney disease (CKD). Activation of microglia in the paraventricular nucleus of the hypothalamus (PVN) has been implicated in SNA. The mechanisms responsible for the adverse prognosis observed in sepsis associated with CKD remain to be determined. Therefore, we aimed to clarify the impact of increased SNA resulting from microglial activation on hemodynamics and organ damage in sepsis associated with CKD. Methods and results: In protocol 1, male Sprague–Dawley rats underwent either nephrectomy (Nx) or sham surgery followed by cecal ligation and puncture (CLP) or sham surgery. After CLP, Nx-CLP rats exhibited decreased blood pressure, increased heart rate, elevated serum creatinine and bilirubin levels, and decreased platelet count compared to Nx-Sham rats. Heart rate variability analysis revealed an increased low to high frequency (LF/HF) ratio in Nx-CLP rats, indicating increased SNA. Nx-CLP rats also had higher creatinine and bilirubin levels and lower platelet counts than sham-CLP rats after CLP. In protocol 2, Nx-CLP rats were divided into two subgroups: one received minocycline, an inhibitor of microglial activation, while the other received artificial cerebrospinal fluid (CSF) intracerebroventricularly via an osmotic minipump. The minocycline-treated group (Nx-mino-CLP) showed attenuated hypotensive and increased heart rate responses compared to the CSF-treated group (Nx-CSF-CLP), and the LF/HF ratio was also decreased. Echocardiography showed larger left ventricular dimensions and inferior vena cava in the Nx-mino-CLP group. In addition, creatinine and bilirubin levels were lower and platelet counts were higher in the Nx-mino-CLP group compared to the Nx-CSF-CLP group. Conclusions: In septic rats with concomitant CKD, SNA was significantly enhanced and organ dysfunction was increased. It has been suggested that the mechanism of exacerbated organ dysfunction in these models may involve abnormal systemic hemodynamics, possibly triggered by activation of the central sympathetic nervous system through activation of microglia in the PVN.

DOI： 10.1186/s40560-024-00742-2

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記述言語：英語   出版者・発行元：The Japanese Society of Physical Fitness and Sports Medicine  

<p>Pelvic fractures, accounting for 2–8% of skeletal injuries, present a significant burden in patients with trauma. High-energy incidents often result in severe pelvic trauma accompanied by comorbidities leading to high mortality rates. Managing these complications adds complexity to the treatment process, particularly in older patients who experience longer recovery times and higher injury severity. To improve the long-term quality of life, a multidisciplinary approach is essential. However, rehabilitation feasibility is influenced by the patient’s condition and pelvic fixation stability, necessitating individualized treatment. This study investigated the rehabilitation status and long-term outcomes of older patients with severe polytrauma and pelvic ring fractures caused by high-energy trauma. The results revealed that 79.2% of the patients achieved full weight-bearing, with a median time of 41.5 days, and eventually 58.3% were discharged home. Complications were observed in 83.3% of the patients, with various challenges affecting successful home discharge. Multidisciplinary rehabilitation programs are promising for optimizing outcomes and facilitating recovery in vulnerable patient populations. Still, larger, more focused studies are needed to gain more comprehensive insights into the treatment and recovery of older patients with pelvic ring fractures and severe polytrauma. Understanding these factors is crucial for guiding clinical decision-making and improving long-term outcomes in this population.</p>

DOI： 10.7600/jpfsm.13.131

CiNii Research

記述言語：英語   出版者・発行元：Pediatric Critical Care Medicine  

OBJECTIVES: To develop an equation for defining a low skeletal muscle mass (SMM) in children and to investigate risk factors and outcomes associated with low SMM in critically ill pediatric patients. DESIGN: Single-center retrospective pediatric cohorts, 2011-2018. SETTING: Tertiary Emergency and Critical Care Center of Kyushu University Hospital in Japan. PATIENTS: We studied two cohorts of pediatric patients 1-15 years old who underwent abdominal CT at the level of the third lumbar vertebra (L3). First a cohort of trauma patients presented to the emergency department in whom we developed an SMM regression equation. Second, a cohort of patients who had undergone abdominal CT within 3 days of PICU admission. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The equation for estimating normal SMM used sex, age, and weight. Low SMM was defined as less than 80% of normal. In the 112 patients in the PICU cohort, median (range) age was 68 (13-191) months, and 83 (74.1%) had underlying disease. There was low SMM in 54 patients (48.2%). Regarding associations, using odds ratio (OR) and 95% CI, we found that low dietary intake (OR 4.33 [95% CI, 1.37-13.70]; p = 0.013) and the presence of underlying disease (OR 7.44 [95% CI, 2.10-26.30]; p = 0.002) were independently associated with greater odds of low SMM. Low SMM, compared with normal SMM, was also associated with longer hospital stays (42.5 d vs. 20.5 d; p = 0.007; β, 1.59; 95% CI, 1.09-2.33; p = 0.016). CONCLUSIONS: In this retrospective PICU cohort from a single center in Japan, we found that low SMM at PICU admission was present in almost half the cases. Low SMM, as defined by being less than 80% of the normal, was associated with greater odds of low dietary intake and underlying chronic disease. Furthermore, low SMM was associated with longer hospital stays.

DOI： 10.1097/PCC.0000000000003511

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Shock  

Background: Histidine-rich glycoprotein (HRG), a potential prognostic factor in sepsis, lacks clarity regarding its relevance in septic-induced shock, disseminated intravascular coagulation (DIC), and acute respiratory distress syndrome (ARDS) pathogenesis. This study investigated the association between HRG concentrations and these critical conditions. Methods: Blood samples were collected from 53 critically ill patients on days 1, 3, 5, and 7 after ICU admission at the Kyushu University Hospital. Daily clinical and laboratory data were recorded, and patient survival was assessed 28 days after ICU admission. Results: Serum HRG concentrations were significantly reduced on days 3, 5, and 7 in patients with septic shock and DIC but not in those with ARDS. While initial HRG levels on day one were not correlated with survival, nonsurvivors displayed decreased HRG levels, notably on days 3, 5, and 7 post-ICU admissions. The HRG levels remained stable in survivors. A progressive decrease was associated with higher mortality rates, particularly on days 5 and 7. On day 5, an HRG level with a cutoff of 25.5 μg/mL showed a sensitivity of 0.77 and a specificity of 0.75, indicating significantly lower survival rates (log-rank test, P < 0.05). Conclusion: HRG presents a potential intervention for critically ill sepsis patients, providing a novel strategy to enhance outcomes. Further research is needed to explore the therapeutic potential of HRG in sepsis management.

DOI： 10.1097/SHK.0000000000002406

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記述言語：日本語   出版者・発行元：大道学館出版部  

出版者・発行元：東京医学社  

DOI： 10.24479/ps.0000000805

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Advanced Robotics  

Early detection and treatment of intraluminal diseases enable minimally invasive surgery and can lead to a high cure rate. Advanced devices with multiple degrees of freedom (DOFs) make narrow intraluminal procedures easier and safer. In a previous study, we developed a multi-DOF compliant endoluminal forceps with a tendon-sheath mechanism. The maximum bending stress of this design was reduced by changing the thickness of a compliant hinge in each segment, and the forceps achieved a wide range of motion. However, its deformed shapes with a non-constant curvature, due to a compliant inhomogeneous-thickness hinge structure, hinder fine manipulation in a narrow lumen. Here, we construct an accurate model of this compliant inhomogeneous-thickness hinge structure using pseudo-rigid-body model. In the proposed method, each compliant hinge is represented by a torsion spring and rotational joint, and the deformed shape is estimated from the bending angle caused by the tensile force. We derive the coefficient of dynamic friction by considering the friction between the wire and compliant joint based on a belt friction model. These novel calculations allow to consider individual differences in material properties and surface roughness. We experimentally confirm the feasibility of constructing a highly accurate model with a lower calculation cost than the finite element method. Our proposal seems suitable for developing dexterous forceps and other endoluminal devices, such as catheters, which mitigate operation errors and help approach lesions in narrow lumens.

DOI： 10.1080/01691864.2023.2291137

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出版者・発行元：東京医学社  

DOI： 10.24479/endo.0000000894

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記述言語：英語  

Patients with infectious diseases including sepsis can develop ST segment changes on an electrocardiogram (ECG) in the absence of coronary artery disease. However, ST elevation with "reciprocal ST segment depression (RSTD)", which is recognized as a specific finding for ST-elevated myocardial infarction, is rare in such patients. Although a small number of cases have reported ST-segment elevation in gastritis, cholecystitis, and sepsis, regardless of coronary artery disease, none presented with reciprocal changes. Here, we describe a rare case of a patient with emphysematous pyelonephritis complicating septic shock who developed ST elevation accompanied by reciprocal changes with no coronary occlusion. Emergency physicians should consider the possibility of acute coronary syndrome mimicking, and choose non-invasive diagnostic procedures when investigating the causes of ECG abnormalities associated with critically ill patients.

DOI： 10.1016/j.ajem.2023.06.038

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DOI： 10.1016/j.ajem.2023.06.038

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掲載種別：研究論文（学術雑誌）  

Patients with infectious diseases including sepsis can develop ST segment changes on an electrocardiogram (ECG) in the absence of coronary artery disease. However, ST elevation with “reciprocal ST segment depression (RSTD)”, which is recognized as a specific finding for ST-elevated myocardial infarction, is rare in such patients. Although a small number of cases have reported ST-segment elevation in gastritis, cholecystitis, and sepsis, regardless of coronary artery disease, none presented with reciprocal changes. Here, we describe a rare case of a patient with emphysematous pyelonephritis complicating septic shock who developed ST elevation accompanied by reciprocal changes with no coronary occlusion. Emergency physicians should consider the possibility of acute coronary syndrome mimicking, and choose non-invasive diagnostic procedures when investigating the causes of ECG abnormalities associated with critically ill patients.

DOI： 10.1016/j.ajem.2023.06.038

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記述言語：日本語   出版者・発行元：(一社)日本集中治療医学会  

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記述言語：日本語   出版者・発行元：(一社)日本集中治療医学会  

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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出版者・発行元：Visual Journal of Emergency Medicine  

DOI： 10.1016/j.visj.2023.101649

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記述言語：日本語   出版者・発行元：西日本整形・災害外科学会  

<p>【はじめに】脊椎術後の頭蓋内出血はまれではあるが報告されている．しかし，頭部外傷を合併した脊椎外傷の術後合併症としてのテント上硬膜下血腫の報告はない．【症例】29歳，男性．4階から墜落して，右急性硬膜下血腫，第12胸椎脱臼骨折を含む胸腰椎多発骨折を受傷した．頭部外傷は保存的治療を選択し，CTによる厳密な評価を行った．血腫の増大はなく脳浮腫が改善した第7病日に，脊椎後方固定術を行った．第10病日に意識障害を来たし，CTで右慢性硬膜下血腫による鉤ヘルニアと診断した．穿頭血腫除去術を行い，速やかに意識は改善した．【考察】脊椎手術後合併症として，小脳出血の報告は多いが，テント上の頭蓋内出血はまれである．過去の頭部外傷が危険因子と考えられているが，報告は少ない．頭部外傷を合併した患者における脊椎手術では，術後に頭蓋内出血を合併する可能性を考慮し，意識の変容の有無を慎重に観察する必要がある．</p>

DOI： 10.5035/nishiseisai.72.128

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記述言語：日本語   出版者・発行元：西日本整形・災害外科学会  

【はじめに】脊椎術後の頭蓋内出血はまれではあるが報告されている.しかし,頭部外傷を合併した脊椎外傷の術後合併症としてのテント上硬膜下血腫の報告はない.【症例】29歳,男性.4階から墜落して,右急性硬膜下血腫,第12胸椎脱臼骨折を含む胸腰椎多発骨折を受傷した.頭部外傷は保存的治療を選択し,CTによる厳密な評価を行った.血腫の増大はなく脳浮腫が改善した第7病日に,脊椎後方固定術を行った.第10病日に意識障害を来たし,CTで右慢性硬膜下血腫による鉤ヘルニアと診断した.穿頭血腫除去術を行い,速やかに意識は改善した.【考察】脊椎手術後合併症として,小脳出血の報告は多いが,テント上の頭蓋内出血はまれである.過去の頭部外傷が危険因子と考えられているが,報告は少ない.頭部外傷を合併した患者における脊椎手術では,術後に頭蓋内出血を合併する可能性を考慮し,意識の変容の有無を慎重に観察する必要がある.(著者抄録)

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：International Journal of Computer Assisted Radiology and Surgery  

Purpose: Gastrointestinal cancer can be treated using a flexible endoscope through a natural orifice. However, treatment instruments with limited degrees of freedom (DOFs) require a highly skilled operator. Articulated devices useful for endoluminal procedures, such as endoscopic submucosal dissection and biopsy, have been developed. These devices enable dexterous operation in a narrow lumen; however, they suffer from limitations such as large size and high cost. To overcome these limitations, we developed a 2.5-mm articulated forceps that can be inserted into a standard endoscope channel based on a compliant mechanism. Methods: The compliant mechanism allows the device to be compact and affordable, which is possible due to its monolithic structure. The proposed mechanism consists of two segments, 1-DOF grasping and 2-DOF bending, that are actuated by tendon-sheath mechanisms. A prototype was designed based on finite element analysis results. Results: To confirm the effectiveness of the proposed mechanism, we fabricated the prototype using a 3D printer. A series of mechanical performance tests on the prototype revealed that it achieved the following specifications: (1) DOF: 1-DOF grasping + 2-DOF bending, (2) outer diameter: 2.5 mm, (3) length of the bending segment: 30 mm, and (4) range of motion: 0 ∘ to 20 ∘ (grasping) and -90∘ to +90∘ (bending). Finally, we performed a tissue manipulation test on an excised porcine colon and found that a piece of mucous membrane tissue was successfully resected using an electric knife while being lifted with the developed forceps. Conclusion: The results of the evaluation experiment demonstrated a positive feasibility of the proposed mechanism, which has a simpler structure compared to those of other conventional mechanisms; furthermore, it is potentially more cost-effective and is disposable. The mechanical design, prototype implementation, and evaluations are reported in this paper.

DOI： 10.1007/s11548-022-02726-9

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その他リンク： https://link.springer.com/article/10.1007/s11548-022-02726-9/fulltext.html

記述言語：英語   出版者・発行元：Chest  

Background: Telemonitoring the use of CPAP devices and remote feedback on device data effectively optimizes CPAP adherence in patients with OSA. Research Question: Can expanding the scope of telemonitoring and remote feedback to body weight (BW), BP, and physical activity enhance efforts for BW reduction in Patients with OSA receiving CPAP? Study Design and Methods: Participants were recruited from patients at 16 sleep centers in Japan with OSA and obesity who were receiving CPAP therapy. Obesity was defined as a BMI of ≥ 25 kg/m2, based on Japanese obesity guidelines. Implementation of CPAP telemonitoring was enhanced with electronic scales, BP monitors, and pedometers that could transmit data from devices wirelessly. Participants were randomized to the multimodal telemonitoring group or the usual CPAP telemonitoring group and were followed up for 6 months. Attending physicians provided monthly telephone feedback calls to the usual CPAP telemonitoring group on CPAP data obtained remotely. In the multimodal telemonitoring group, physicians additionally encouraged participants to reduce their BW, after sharing the remotely obtained data on BW, BP, and step count. The primary outcome was set as ≥ 3% BW reduction from baseline. Results: One hundred sixty-eight participants (BMI, 31.7 ± 4.9 kg/m2) completed the study, and ≥ 3% BW reduction occurred in 33 of 84 participants (39.3%) and 21 of 84 participants (25.0%) in the multimodal telemonitoring and usual CPAP telemonitoring groups, respectively (P = .047). Whereas no significant differences were found between the two groups in the change in office and home BP, daily step counts during the study period were significantly higher in the multimodal telemonitoring group than in the usual CPAP telemonitoring group (4,767 steps/d [interquartile range (IQR), 2,864-6,617 steps/d] vs 3,592 steps/d [IQR, 2,117-5,383 steps/d]; P = .02) Interpretation: Multimodal telemonitoring may enhance BW reduction efforts in patients with OSA and obesity. Trial Registry: UMIN Clinical Trials Registry; No.: UMIN000033607; URL: www.umin.ac.jp/ctr/index.htm

DOI： 10.1016/j.chest.2022.07.032

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記述言語：日本語   出版者・発行元：(一社)日本救急医学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of International Medical Research  

Objective: This study was performed to evaluate the correlation between parameters measured by bedside ultrasonography and detection of intracranial organic lesions in patients with impaired consciousness in an intensive care unit (ICU) setting. Methods: We retrospectively reviewed the medical records of patients who were admitted to our ICU from April 2017 to July 2019. Patients who underwent computed tomography or magnetic resonance imaging examination and measurement of the flow velocity of the carotid and intracranial arteries and the optic nerve sheath diameter by ultrasonography were selected for analysis. Results: In total, 64 patients were analyzed in this study. Of these, intracranial lesions were detected by computed tomography or magnetic resonance imaging in 17 (27%) patients. The left:right ratio of the end-diastolic velocity of the bilateral common carotid artery (CCA-ED ratio) and the pulsatility index of the middle cerebral artery (MCA-PI) were significantly higher in patients with than in those without intracranial lesions. The cut-off value of the CCA-ED ratio was 1.55 (sensitivity, 66.7%; specificity, 81.6%), and that of the MCA-PI was 1.21 (sensitivity, 57.1%; specificity, 76.7%). Conclusion: Bedside ultrasonography is useful for predicting intracranial lesions requiring therapeutic intervention in ICU patients with impaired consciousness.

DOI： 10.1177/03000605221119358

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Antioxidants  

Doxorubicin (DOX) induces dose-dependent cardiotoxicity via oxidative stress and abnormal mitochondrial function in the myocardium. Therefore, a noninvasive in vivo imaging procedure for monitoring the redox status of the heart may aid in monitoring diseases and developing treatments. However, an appropriate technique has yet to be developed. In this study, we demonstrate a technique for detecting and visualizing the redox status of the heart using in vivo dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) with 3-carbamoyl-PROXYL (CmP) as a molecular imaging probe. Male C57BL/6N mice were administered DOX (20 mg/kg) or saline. DNP-MRI clearly showed a slower DNP signal reduction in the DOX group than in the control group. Importantly, the difference in the DNP signal reduction rate between the two groups occurred earlier than that detected by physiological examination or clinical symptoms. In an in vitro experiment, KCN (an inhibitor of complex IV in the mitochondrial electron transport chain) and DOX inhibited the electron paramagnetic resonance change in H9c2 cardiomyocytes, suggesting that the redox metabolism of CmP in the myocardium is mitochondrion-dependent. Therefore, this molecular imaging technique has the potential to monitor the dynamics of redox metabolic changes in DOX-induced cardiomyopathy and facilitate an early diagnosis of this condition.

DOI： 10.3390/antiox11081454

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記述言語：英語   出版者・発行元：John Wiley & Sons Australia, Ltd  

症例は1歳男児で、竹串による上顎顔面損傷のため救急搬送された。竹串は口腔前庭上部に約5cm穿通していると考えられた。鼻血を除き、バイタルサインや検査値は正常であった。CTにて、竹串が篩骨を貫通し頭蓋内腔に達していたが、明らかな頭蓋内出血や脳損傷はなかった。髄膜脳炎予防のため抗生物質投与を開始し、経鼻ファイバースコープを用いて鎮静下で竹串を抜去した。鼻性髄液漏や出血は認められなかった。処置後のCTにて気頭症を認め、抗生物質を継続した。入院中、体温は39.8℃に達し、白血球数とC反応性蛋白が増加したが、2日目の髄液検査では髄膜脳炎を認めなかった。徐々に発熱と検査値が改善し、3日目に経口摂取を開始した。静脈内抗生物質療法を2週間継続し、14日目に症状なく退院した。

掲載種別：研究論文（学術雑誌）   出版者・発行元：Applied Sciences (Switzerland)  

Gastrointestinal cancer, when detected early, is treated by accessing the lesion through the natural orifice using flexible endoscopes. However, the limited degree-of-freedom (DOF) of conventional treatment devices and the narrow surgical view through the endoscope demand advanced techniques. In contrast, multi-DOF forceps systems are an excellent alternative; however, these systems often involve high fabrication costs because they require a large number of micro-parts. To solve this problem, we designed compact multi-DOF endoluminal forceps with a monolithic structure comprising compliant hinges. To allow an efficient stress dispersion at the base end when the hinge bends, we proposed a novel design method to obtain the hinge parameters using the beam of uniform strength theory. This method does not involve a high computational cost. The results show that the improved design with a variable hinge thickness can reduce the maximum bending stress, dispersing the stress in a larger area than that of the previous design considering a constant thickness of the hinge. Moreover, the experiments conducted in a prototype confirm that the radius of the curvature was significantly improved. The proposed method could aid in designing other continuum robots relying on compliant hinges.

DOI： 10.3390/app12052480

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記述言語：英語   出版者・発行元：Disaster Medicine and Public Health Preparedness  

Objective: Based on experiences following the Great East Japan Earthquake and nuclear power plant accident in 2011, Nuclear Emergency Core Hospitals (NECHs) were designated as centers for radiation disaster management in Japan. This study aimed to investigate their current status and identify areas for improvement. Methods: This cross-sectional study was conducted in October 2018. Demographic data were collected by a questionnaire with free text responses about attitudes toward NECHs. Considerations regarding risk communications during a radiation disaster were analyzed using qualitative text mining analysis. Results: A total of 36 hospitals participated in this study. Only 31% of NECHs anticipated a radiation disaster. The importance of business continuity plans and risk communications was shown. Text analysis identified 7 important categories for health care workers during a radiation disaster, including media response, communications to hospital staff, risk communications, radiation effects on children, planning for a radiation disaster in the region, rumors, and the role in the region. Conclusion: The radiation disaster medical system and NECHs in Japan were surveyed. The importance of risk communications, planning for a radiation disaster in each region, and the role in the region are identified as issues that need to be addressed.

DOI： 10.1017/dmp.2021.348

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記述言語：英語   出版者・発行元：Pediatrics International  

DOI： 10.1111/ped.15018

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Clinical and Applied Thrombosis/Hemostasis  

Recombinant antithrombin gamma (rAT) is reported as an effective drug for patients with disseminated intravascular coagulation (DIC) in Japan. As the appropriate dose and targeted AT activity remain unknown, this study aimed to determine these aspects for sepsis-induced DIC. Thirty-one patients with septic shock and DIC with AT levels <70% were treated with rAT between May 2018 and December 2020. The recovery rates from DIC were 32.2% and 63.3% on day 3 and 5 post administration, respectively. Recovery and survival rates were significantly higher in patients who achieved AT activity ≥70% or 80% on day 3 post administration. Receiver operating characteristic curve analysis revealed that the cutoff values of post-treatment AT activity on day 3 for 28-day survival and 5-day recovery from DIC were 79.5% and 81.5%, respectively. Patients who did not achieve AT activity ≥80% on day 3 presented a lower base level of AT activity and lower dose supplementation. Our results suggest that targeted AT activity should be at least 70%, and ideally 80%, and sufficient doses to maintain this activity are required to achieve better outcomes.

DOI： 10.1177/10760296221135790

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmermd.2022.1p1-m10

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.4251/wjgo.v13.i8.822

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Antioxidants and Redox Signaling  

Significance: In vivo molecular and metabolic imaging is an emerging field in biomedical research that aims to perform noninvasive detection of tissue metabolism in disease states and responses to therapeutic agents. The imbalance in tissue oxidation/reduction (Redox) states is related to the onset and progression of several diseases. Tissue redox metabolism provides biomarkers for early diagnosis and drug treatments. Thus, noninvasive imaging of redox metabolism could be a useful, novel diagnostic tool for diagnosis of redox-related disease and drug discovery. Recent Advances: In vivo dynamic nuclear polarization magnetic resonance imaging (DNP-MRI) is a technique that enables the imaging of free radicals in living animals. DNP enhances the MRI signal by irradiating the target tissue or solution with the free radical molecule's electron paramagnetic resonance frequency before executing pulse sequence of the MRI. In vivo DNP-MRI with redox-sensitive nitroxyl radicals as the DNP redox contrast agent enables the imaging of the redox metabolism on various diseases. Moreover, nitroxyl radicals show antioxidant effects that suppress oxidative stress. Critical Issues: To date, considerable progress has been documented preclinically in the development of animal imaging systems. Here, we review redox imaging of in vivo DNP-MRI with a focus on the recent progress of this system and its uses in patients with redox-related diseases. Future Directions: This technique could have broad applications in the study of other redox-related diseases, such as cancer, inflammation, and neurological disorders, and facilitate the evaluation of treatment response as a theranostic tool.

DOI： 10.1089/ars.2021.0087

Web of Science

Scopus

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/lt.25960

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Tissue redox metabolism is involved in various diseases, and an understanding of the spatio-temporal dynamics of tissue redox metabolism could be useful for diagnosis of progression and treatment. In in vivo dynamic nuclear polarization (DNP)-MRI, electron paramagnetic resonance (EPR) irradiation at the resonance frequency of nitroxyl radicals administered as a redox probe for induction of DNP, increases the intensity of MRI signals. For electron spin, it is necessary to apply a resonant frequency 658 times higher than that required for nuclear spin because of the higher magnetic moment of unpaired electrons. Previous studies using a disease model of small animals and in vivo DNP-MRI have revealed that an abnormal redox status is involved in many diseases, and that it could be used to visualize the dynamics of alterations in redox metabolism. To use the current methods in clinical practice, the development of a prototype DNP-MRI system for preclinical examinations of large animals is indispensable for clarifying the problems peculiar to the increase in size of the DNP-MRI device. Therefore, we developed a in vivo DNP-MRI system with a sample bore size of 20 cm and a 16-mT magnetic field using a U-shaped permanent magnet. Because the NMR frequency is very low, we adopted a digital radiofrequency transmission/reception system with excellent filter and dynamic range characteristics and equipped with a digital eddy current compensation system to suppress large eddy currents. The pulse sequence was based on the fast spin-echo sequence, which was improved for low frequency and large-eddy current equipment. The in vivo DNP-MRI system developed was used to non-invasively image the redox reaction of a carbamoyl-PROXYL probe in the livers of large rats weighing 800 g. Furthermore, DNP-MRI analysis was able to capture significant changes in redox metabolism in hepatitis-model rats.

DOI： 10.1016/j.freeradbiomed.2021.04.017

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/MD.0000000000026313

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1080/10715762.2020.1859109

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/SLE.0000000000000929

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/MD.0000000000024929

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s41927-020-00164-1

記述言語：英語  

DOI： 10.1016/j.jiac.2020.08.001

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13287-020-02015-9

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/s41598-020-73336-1

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.lfs.2020.118074

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.intimp.2020.106462

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s40792-019-0762-y

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s10147-019-01499-7

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1055/a-0990-9189

記述言語：英語  

DOI： 10.1002/ams2.438

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/hepr.13343

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s00464-018-6408-5

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s00464-018-6188-y

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/s41598-017-17447-2

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.ajem.2017.06.011

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/srep32604

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/liv.12962

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/jgh.12893

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s11548-014-0989-9

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s00068-014-0478-4

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.15017/1440929

記述言語：英語  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.15017/1440926

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.15017/1440930

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.15017/26659

記述言語：英語  

記述言語：英語  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/1471-230X-12-158

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/j.1872-034X.2012.01021.x

記述言語：英語  

記述言語：日本語  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s00595-010-4484-9

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1055/s-2001-17919

記述言語：英語   掲載種別：研究論文（学術雑誌）  

総ページ数：9  

CiNii Research

記述言語：日本語   著書種別：一般書・啓蒙書

記述言語：日本語   著書種別：一般書・啓蒙書

開催年月日： 2010年8月

記述言語：その他   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：横浜市   国名：日本国  

開催年月日： 2010年4月 - 2011年4月

記述言語：その他   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：東京   国名：日本国  

開催年月日： 2010年3月

記述言語：その他   会議種別：口頭発表（一般）  

開催地：富山   国名：日本国  

開催年月日： 2009年5月

記述言語：その他  

国名：日本国  

開催年月日： 2014年3月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：東京   国名：日本国  

開催年月日： 2013年11月

記述言語：日本語  

開催地：福岡   国名：日本国  

開催年月日： 2013年11月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：福岡   国名：日本国  

開催年月日： 2013年11月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：福岡   国名：日本国  

開催年月日： 2013年11月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：福岡   国名：日本国  

開催年月日： 2013年9月

記述言語：日本語  

開催地：名古屋   国名：日本国  

開催年月日： 2013年9月

記述言語：日本語  

開催地：名古屋   国名：日本国  

開催年月日： 2013年9月

記述言語：日本語  

開催地：名古屋   国名：日本国  

開催年月日： 2013年9月

記述言語：日本語  

開催地：名古屋   国名：日本国  

開催年月日： 2013年9月

記述言語：日本語  

開催地：名古屋   国名：日本国  

開催年月日： 2013年9月

記述言語：日本語  

開催地：北九州   国名：日本国  

開催年月日： 2013年7月

記述言語：日本語  

開催地：宮崎市   国名：日本国  

開催年月日： 2013年7月

記述言語：日本語  

開催地：宮崎市   国名：日本国  

開催年月日： 2013年7月

記述言語：日本語  

開催地：熊本   国名：日本国  

開催年月日： 2013年7月

記述言語：英語  

国名：日本国  

開催年月日： 2012年12月

記述言語：日本語  

開催地：横浜   国名：日本国  

開催年月日： 2012年9月

記述言語：その他  

開催地：東京   国名：日本国  

開催年月日： 2012年9月

記述言語：その他  

開催地：東京   国名：日本国  

開催年月日： 2012年8月

記述言語：日本語  

開催地：札幌   国名：日本国  

開催年月日： 2012年7月

記述言語：その他  

開催地：富山   国名：日本国  

開催年月日： 2012年7月

記述言語：日本語  

開催地：富山   国名：日本国  

開催年月日： 2012年7月

記述言語：その他  

開催地：富山   国名：日本国  

開催年月日： 2012年6月

記述言語：その他  

開催地：福岡   国名：日本国  

開催年月日： 2012年6月

記述言語：日本語  

開催地：福岡   国名：日本国  

開催年月日： 2012年6月

記述言語：英語  

国名：イタリア共和国  

開催年月日： 2012年6月

記述言語：日本語  

開催地：金沢   国名：日本国  

開催年月日： 2012年5月

記述言語：その他  

開催地：福岡   国名：日本国  

開催年月日： 2012年5月

記述言語：その他  

国名：日本国  

開催年月日： 2012年5月

記述言語：その他  

開催地：東京   国名：日本国  

開催年月日： 2012年4月

記述言語：日本語  

開催地：名古屋   国名：日本国  

開催年月日： 2012年4月

記述言語：日本語  

開催地：千葉   国名：日本国  

開催年月日： 2012年4月

記述言語：日本語  

開催地：千葉   国名：日本国  

開催年月日： 2012年4月

記述言語：日本語  

開催地：千葉   国名：日本国  

開催年月日： 2012年3月

記述言語：その他   会議種別：口頭発表（一般）  

開催地：石川   国名：日本国  

開催年月日： 2012年3月

記述言語：英語  

国名：アメリカ合衆国  

開催年月日： 2012年2月

記述言語：日本語  

開催地：福岡   国名：日本国  

開催年月日： 2011年10月

記述言語：日本語  

開催地：東京   国名：日本国  

開催年月日： 2011年9月

記述言語：日本語  

開催地：福岡   国名：日本国  

開催年月日： 2011年8月

記述言語：英語  

国名：日本国  

開催年月日： 2011年8月

記述言語：英語  

国名：日本国  

開催年月日： 2011年8月

記述言語：日本語  

開催地：名古屋   国名：日本国  

開催年月日： 2011年7月

記述言語：日本語  

開催地：名古屋   国名：日本国  

近年消化器外科医は、専門分化され、外傷診療を担える外科医は減りつつある。よって重症外傷に伴う腹部臓器損傷に対して無力となっており、助けれるはずの患者を救命できない現状が存在する。その問題点と方策について検討した。

開催年月日： 2011年3月

記述言語：日本語  

開催地：福岡   国名：日本国  

記述言語：その他   会議種別：口頭発表（一般）  

国名：アメリカ合衆国  

記述言語：その他   会議種別：口頭発表（一般）  

国名：カナダ  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語   出版者・発行元：東京臨床出版(株)  

記述言語：日本語   出版者・発行元：(公財)ヤクルト・バイオサイエンス研究財団  

記述言語：日本語   出版者・発行元：(株)東京医学社  

記述言語：日本語   出版者・発行元：西日本整形・災害外科学会  

J-GLOBAL

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記述言語：日本語  

記述言語：英語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

2005年から2013年8月までに行った腹腔鏡下腹壁ヘルニア修復術65例を対象とし、再発や合併症を低減するための手技の工夫とその治療成績を報告した。当科では、腹壁ヘルニアの治療の基本はメッシュを用いた腹腔鏡下修復術と考え、ポート挿入位置、癒着剥離、メッシュのサイズの決定と固定部位のマーキング、メッシュの固定、seromaの予防、術後などの手技を工夫している。自験例では平均ヘルニア門長径8.3cm、平均手術時間177分、平均出血量23g、平均術後入院日数12.1日で開腹移行は4例(6.2&#37;)であった。合併症は遅発性腸管損傷1例(1.5&#37;)で、メッシュ感染やメッシュの癒着に伴う腸管瘻はなく、再発は傍ストーマヘルニアの1例(1.5&#37;)のみで平均観察期間は2年であった。腹腔鏡下腹壁ヘルニア修復術は腹壁ヘルニア治療の第一選択になり得ると考えられた。

記述言語：日本語  

脾摘術または腹腔鏡下脾摘術を行った慢性C型肝炎/肝硬変患者36人について、脾摘前後の肝機能と門脈血行動態の変化を調査し、脾摘の意義を検討した。平均脾重量396g、平均白血球数3,945/μl、Child Pugh分類はA 16例、B 19例、C 1例、術前の肝静脈波型はI型18例、II型18例であり、術前、術後6ヵ月、1年の肝機能検査値、肝硬変の重症度診断、ならびに術前、術後7日目の門脈血流量や血流速度、肝静脈波型を評価した。その結果、慢性C型肝炎/肝硬変患者では脾摘後に門脈血流量や血流速度が低下しており、肝静脈波型がII型からI型に改善した14例では肝機能の改善がみられた。今回、脾摘による門脈血流量および門脈血流速度の低下が肝機能改善に関与している可能性が示唆され、肝静脈波型の変化によって脾摘後の肝機能改善に違いがあることが明らかとなった。

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：その他  

記述言語：日本語  

記述言語：その他  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

参加者数：200

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

対象： 幼稚園以下,　小学生,　中学生,　高校生

種別：セミナー・ワークショップ

種別：セミナー・ワークショップ

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種別：テレビ・ラジオ番組

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対象： 幼稚園以下,　小学生,　中学生,　高校生

種別：その他

種別：その他

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