Updated on 2024/12/27

Information

 

写真a

 
SUDO NOBUYUKI
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Professor
School of Medicine Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medical Sciences(Concurrent)
Title
Professor
Contact information
メールアドレス
Tel
0926425316
Profile
Our recent research targets the effects of environmental factor on neuro-immuno-endocrine interaction.
Homepage
External link

Degree

  • Doctor of Medicine

Research History

  • 飯塚病院(2年間), 壱岐公立病院(1年間)等

    飯塚病院(2年間), 壱岐公立病院(1年間)等

Research Interests・Research Keywords

  • Research theme:Clarification of Anorexia Nervosa patients condition by Microbiota gut-brain axis

    Keyword:Anorexia Nervosa, Microbiota gut-brain axis

    Research period: 2016.4 - 2019.3

  • Research theme:Stress causes bacterial trans location.

    Keyword:stress, bacterial trans location

    Research period: 2016.4 - 2018.3

  • Research theme:Talks with bacteria and the host through catecholamine:Creation of a new paradigm of the mind and body correlation

    Keyword:Inter-kingdom signaling, catecholamine, stress

    Research period: 2014.4 - 2015.3

  • Research theme:The whole aspect and elucidation of the mechanism of the host action change due to intestinal bacteria

    Keyword:Intestinal bacteria, stress, metabolic loam

    Research period: 2013.4 - 2015.3

  • Research theme:How does the stress bring about the fortunetelling infectiousness of the host?

    Keyword:Inter-kingdom signaling, catecholamine, stress, infectious disease

    Research period: 2012.4 - 2014.3

  • Research theme:Does enteral Flora influence the weight gain of the anorexic?

    Keyword:Enteral Flora, adiposity, anorexia nervosa, eating disorder

    Research period: 2010.4 - 2011.3

  • Research theme:The Gut Microbiome Derived From Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Female Mice.

    Keyword:Microbiome

    Research period: 2000.1

  • Research theme:Psychoneuoimmunology

    Keyword:stress, nervous system, endocrine system, immune system, interaction

    Research period: 1997.4

Papers

  • The Gut Microbiome Derived from Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Female Mice Reviewed International journal

    Hata T,Miyata N,Takakura S, Yoshihara K,Asano Y, Kimura-Todani T, Yamashita M, Xue Ting Zhang, Watanabe N, Mikami K, Koga Y,Sudo N.

    Endocrinology   160 ( 10 )   2441 - 2452   2019.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2019-00408

  • QseC inhibition as an antivirulence approach for colitis-associated bacteria Reviewed International journal

    Michelle G. Rooks, Patrick Veiga, Analise Z. Reeve, Sydney Lavoie, Yasuda K, Asano Y, Yoshihara K, Michaud M, Leslie Wardwell-Scott, Carey Ann Gallini, Jonathan N. Glickman, Sudo N, Curtis Huttenhower, Cammie F. Lesser, Wendy S. Garretta

    Proceedings of the National Academy of Sciences of the United States of America   114 ( 1 )   142 - 147   2017.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.1612836114

  • Gut Dysbiosis in Patients with Anorexia Nervosa Reviewed International journal

    Morita C, Tsuji H, Hata T, Gondo M, Takakura S, Kawa Ki,Yoshihara K, Ogata K, Nomoto K, Miyazaki K, Sudo N.

    PloS one   10 ( 12 )   e0145274   2015.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0145274

  • Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods Reviewed

    Nishino R, Mikami K, Takahashi H, Tomonaga S, Hiramoto T, Aiba Y, Koga Y, Sudo N.

    Neurogastroenterology and Motility   25 ( 6 )   521 - e371   2013.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/nmo.12110

  • Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice Reviewed International journal

    Asano Y,Hiramoto T, Nishino R, Aiba Y, Kimura T, Yoshihara K, Koga Y, Sudo N.

    American Journal of Physiology - Gastrointestinal and Liver Physiology   303 ( 11 )   G1288 - G1295   2012.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpgi.00341.2012

  • Mood and gut feelings Reviewed International journal

    Forsythe P, Sudo N, Dinan T, Taylor VH, Bienenstock J

    Brain Behav Immun.   24 ( 1 )   2010.1

     More details

    Language:English  

  • The hepatic vagus nerve attenuates Fas-induced apoptosis in the mouse liver via alpha7 nicotinic acetylcholine receptor. Reviewed International journal

    Hiramoto T, Chida Y, Sonoda J, Yoshihara K,Sudo K,Kubo C.

    Gastroenterology   134 ( 7 )   2122 - 31   2008.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.gastro.2008.03.005

  • Early-life psychological stress exacerbates adult mouse asthma via the hypothalamus-pituitary-adrenal axis. Reviewed International journal

    Chida Y, Sudo N, Sonoda J, Hiramoto T, Kubo C.

    Am J Respir Crit Care Med.   2007.2

     More details

    Language:English  

  • The hepatic sympathetic nerve plays a critical role in preventing Fas induced liver injury in mice. Reviewed International journal

    Chida Y, Sudo N, Takaki A, Kubo C.

    Gut   54 ( 7 )   994 - 1002   2005.7

     More details

    Language:English  

    DOI: 10.1136/gut.2004.058818

  • Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system fo stress response in mice. Reviewed International journal

    Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, Kubo C, Koga Y.

    Journal of Physiology (London)   558 ( 1 )   263 - 275   2004.7

     More details

    Language:English  

    DOI: 10.1113/jphysiol.2004.063388

  • Electric foot-shock stress-induced excerbation of alpha-galactosylceramide-triggered apoptosis in the mouse liver. Reviewed International journal

    Chida Y, Sudo N, Sonoda J, Sogawa H, Kubo C.

    Hepatology   39 ( 4 )   1131 - 1140   2004.3

     More details

    Language:English  

    DOI: 10.1002/hep.20158

  • The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction Reviewed International journal

    Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y.

    Journal of Immunology   159 ( 4 )   1739 - 1745   1997.8

     More details

    Language:English  

  • Possible contribution of gut dysbiosis to the pathology of anorexia nervosa

    Sudo, N

    PSYCHOTHERAPY AND PSYCHOSOMATICS   93   24 - 24   2024.8   ISSN:0033-3190 eISSN:1423-0348

     More details

  • Neural correlates of psychotherapy: focusing on perspective-taking

    Izuno, S; Koike, T; Tsuchimoto, S; Ogasawara, K; Hashiguchi, M; Yoshioka, A; Yoshihara, K; Sudo, N; Fukunaga, M; Sadato, N

    PSYCHOTHERAPY AND PSYCHOSOMATICS   93   36 - 36   2024.8   ISSN:0033-3190 eISSN:1423-0348

     More details

  • Energy requirements for weight gain in patients with anorexia nervosa: a study from a Japanese medical prison

    Suzuyama, CA; Takakura, S; Takii, M; Toda, K; Yamashita, M; Hata, T; Sudo, N

    PSYCHOTHERAPY AND PSYCHOSOMATICS   93   149 - 149   2024.8   ISSN:0033-3190 eISSN:1423-0348

     More details

  • Association between the white matter microstructure and psychological factors in patients with fibromyalgia

    Izuno, S; Yoshihara, K; Hosoi, M; Eto, S; Hirabayashi, N; Todani, T; Gondo, M; Hayaki, C; Anno, K; Sudo, N

    PSYCHOTHERAPY AND PSYCHOSOMATICS   93   74 - 74   2024.8   ISSN:0033-3190 eISSN:1423-0348

     More details

  • The optimal cut-off score of the Eating Attitude Test-26 for screening eating disorders in Japan

    Nohara, N; Hiraide, M; Horie, T; Takakura, S; Hata, T; Sudo, N; Yoshiuchi, K

    EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY   29 ( 1 )   42   2024.6   ISSN:1124-4909 eISSN:1590-1262

     More details

    Language:English   Publisher:Eating and Weight Disorders  

    Purpose: The Eating Attitude Test-26 (EAT-26) is a screening tool for eating disorders (EDs) in clinical and non-clinical samples. The cut-off score was suggested to be varied according to target population. However, no studies have examined the appropriateness of the originally proposed score of 20 for screening DSM-5 eating disorders in Japan. This study aimed to identify an appropriate cut-off score to better differentiate clinical and non-clinical samples in Japan for EDs. Methods: The participants consisted of 54 patients with anorexia nervosa restricting type, 58 patients with anorexia nervosa binge-eating/purging type, 37 patients with bulimia nervosa diagnosed according to DSM-5 criteria, and 190 healthy controls (HCs). Welch’s t test was used to assess differences in age, body mass index (BMI), and total EAT-26 scores between HCs and patients with EDs. Receiver operating characteristic (ROC) analysis was conducted to identify the optimal cut-off score. Results: The HCs had significantly higher BMI and lower total EAT-26 mean scores than patients with EDs. The area under the ROC curve was 0.925, indicating that EAT-26 had excellent performance in discriminating patients with EDs from HCs. An optimal cut-off score of 17 was identified, with sensitivity and specificity values of 0.866 and 0.868, respectively. Conclusions: The result supports the suggestions that optimal cut-off score should be different according to target populations. The newly identified cut-off score of 17 would enable the identification of patients with EDs who have been previously classified as non-clinical samples in the EAT-26 test. Level of evidence: III: evidence obtained from case–control analytic study.

    DOI: 10.1007/s40519-024-01669-1

    Web of Science

    Scopus

    PubMed

  • Case Report: Nonverbal approaches in the treatment of a patient with fibromyalgia with anger rooted in adverse childhood experiences

    Adachi, Y; Hosoi, M; Nishihara, T; Hirabayashi, N; Sawa, T; Matsushita, T; Tatsushima, K; Anno, K; Tomioka, M; Sudo, N

    FRONTIERS IN PAIN RESEARCH   5   1374324   2024.5   ISSN:2673-561X eISSN:2673-561X

     More details

    Language:English   Publisher:Frontiers in Pain Research  

    Introduction: In psychotherapy, it is important to establish and deepen a therapeutic trusting relationship, but patients who have experienced extreme adversity in childhood tend to have difficulty in building such a relationship. This paper reports a case of fibromyalgia with adverse childhood experiences (ACEs) in which a nonverbal approach was successful in building a trusting relationship. Case and methods: The patient is a woman in her late 40s. She had strong anger rooted in ACEs, including neglect by her father, a feeling of unfair parenting by her mother compared to her younger brother, overcontrol of her life by her mother, and sexual abuse by her uncle. She was filled with strong interpersonal distrust and anger, and the experience of an unsuccessful surgery compounded her distrust of medical care. The therapist initially had severe difficulty in verbal interaction with the patient. When conducting “drawing” therapy, she ignored the therapist's comments and completely blacked out the drawing paper. However, the patient-therapist relationship gradually changed, and verbal interaction became possible through the use of nonverbal approaches such as framing her drawing paper and “Towel Baby Holding.” Results: The therapist was able to understand the patient's emotions through these nonverbal approaches and to communicate with the patient that she understood her feelings. This approach was also successful in the patient’s understanding of her own pathology. The patient became able to honestly express her feelings in words, which eventually enabled her to be introduced to mindfulness therapy, leading to a favorable treatment course. Conclusion: For patients with ACEs, a nonverbal approach helps build a therapeutic relationship and plays an important role in understanding the patient.

    DOI: 10.3389/fpain.2024.1374324

    Web of Science

    Scopus

    PubMed

  • Association Between Serum NT-proBNP and Gray Matter Atrophy Patterns in an Older Japanese Population: The Hisayama Study

    Hirabayashi, N; Hata, J; Furuta, Y; Nakazawa, T; Ohara, T; Shibata, M; Yamashita, F; Kitazono, T; Sudo, N; Ninomiya, T

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES   79 ( 5 )   2024.5   ISSN:1079-5006 eISSN:1758-535X

     More details

    Language:English   Publisher:Journals of Gerontology - Series A Biological Sciences and Medical Sciences  

    Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1 201 community-dwelling Japanese aged =65 years. Regional gray matter volumes (GMV) and intracranial volume (ICV) were estimated by applying voxel-based morphometry (VBM) methods. The associations of serum NT-proBNP with regional GMV/ICV were examined by analysis of covariance. The regional gray matter atrophy patterns associated with elevated serum NT-proBNP levels were investigated using VBM without a priori regions of interest. The multivariable-adjusted means of the frontal, temporal, hippocampal, parahippocampal, and entorhinal GMV/ICV decreased significantly with elevated serum NT-proBNP levels (all p for trend and q values of false discovery rate correction < .05). In VBM, elevated serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral entorhinal areas, bilateral fusiform gyri, left middle temporal gyrus, left inferior temporal gyrus, right central operculum, right posterior orbital gyrus, bilateral middle frontal gyri, anterior cingulate gyrus and bilateral medial frontal cortices. In a sensitivity analysis excluding 254 participants with mild cognitive impairment or dementia, serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral fusiform gyri, and left middle frontal gyrus. Our data suggest that elevated serum NT-proBNP levels are associated with gray matter atrophy in brain regions that play an important role in cognitive function.

    DOI: 10.1093/gerona/glae075

    Web of Science

    Scopus

    PubMed

  • Association Between Serum NT-proBNP and Gray Matter Atrophy Patterns in an Older Japanese Population: The Hisayama Study. Reviewed International journal

    Hirabayashi N, Hata J, Furuta Y, Nakazawa T, Ohara T, Shibata M, Yamashita F, Kitazono T, Sudo N, Ninomiya T.

    J Gerontol A Biol Sci Med Sci.   2024.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/gerona/glae075.

  • Autonomic nervous system function assessed by heart rate variability and the presence of symptoms affecting activities of daily living in community-dwelling residents with chronic pain: The Hisayama Study. Reviewed International journal

    Nakamura Y, Shibata M, Morisaki Y, Hirabayashi N, Higashioka M, Hata J, Hosoi M, Sudo N, Yamaura K, Ninomiya T.

    Eur J Pain.   28 ( 5 )   831 - 844   2024.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ejp.2224.

  • Autonomic nervous system function assessed by heart rate variability and the presence of symptoms affecting activities of daily living in community-dwelling residents with chronic pain: The Hisayama Study

    Nakamura, Y; Shibata, M; Morisaki, Y; Hirabayashi, N; Higashioka, M; Hata, J; Hosoi, M; Sudo, N; Yamaura, K; Ninomiya, T

    EUROPEAN JOURNAL OF PAIN   28 ( 5 )   831 - 844   2024.5   ISSN:1090-3801 eISSN:1532-2149

     More details

    Language:English   Publisher:European Journal of Pain (United Kingdom)  

    Background: Autonomic nervous system dysfunction has been reported to be associated with impaired activities of daily living (ADL) among patients with chronic pain, but the association has not been fully addressed in general populations. This study cross-sectionally investigated the association between autonomic nervous system function and the presence of subjective symptoms affecting ADL in community-dwelling residents with chronic pain. Methods: A total of 888 residents with chronic pain, aged 40–79 years, who underwent a health examination in 2017–2018 were included. Based on heart rate variability measured by fingertip pulse wave, the standard deviation of normal-to-normal intervals (SDNN), root mean square of successive RR interval differences (RMSSD), low frequency (LF) power, and high frequency (HF) power were calculated. Symptoms affecting ADL were defined as those scoring ≥1 on the modified Rankin Scale. Odds ratios (ORs) and their 95% confidence intervals (CIs) for symptoms affecting ADL were estimated using a logistic regression analysis. Results: The overall prevalence of symptoms affecting ADL was 39.4%. The ORs for symptoms affecting ADL increased significantly per 1-standard-deviation decrement in log-transformed SDNN (OR 1.23 [95% CI 1.06–1.44]), RMSSD (1.25 [1.08–1.45]), LF power (1.29 [1.11–1.52]), and HF power (1.29 [1.11–1.51]) after adjusting for age, sex, education, hypertension, diabetes, serum total cholesterol level, body mass index, past medical history, current smoking, current drinking, exercise, depressive symptoms, and pain intensity. Conclusions: Decreased heart rate variability was associated with the presence of symptoms affecting ADL among individuals with chronic pain in a Japanese community. Significance: Decrease in heart rate variability was associated with the presence of symptoms affecting ADL among individuals with chronic pain in a Japanese community. This article could help scientists understand the significance of autonomic nervous system dysfunction in the pathology of chronic pain. Approaches that target autonomic nervous system dysfunction may be an option to relieve or prevent symptoms affecting ADL for chronic pain sufferers.

    DOI: 10.1002/ejp.2224

    Web of Science

    Scopus

    PubMed

  • Psychosomatic Correlates in Obesity

    Nozaki Takehiro, Yokoyama Hiroaki, Nishihara Tomoe, Sawamoto Ryoko, Takakura Shu, Komaki Gen, Sudo Nobuyuki

    Japanese Journal of Psychosomatic Medicine   64 ( 6 )   516 - 525   2024   ISSN:03850307 eISSN:21895996

     More details

    Language:Japanese   Publisher:Japanese Society of Psychosomatic Medicine  

    <p>Obesity is considered to be a complex, multifactorial disease resulting from the interaction of genetic, environmental, physiological, biochemical, psychosocial, and behavioral factors. Although obesity is a physical disease, it can be considered a classic psychosomatic disorder because psychosocial factors are involved in its onset and course. Obesity is closely related to lifestyle habits, including eating behavior, which is particularly affected by stress in daily life. In addition, a high percentage of patients suffer from comorbid psychiatric disorders, such as depression and anxiety, eating, and sleep disorders. Recently, it has become clear that social prejudice and discrimination against people with obesity (obesity stigma) have more negative effects on mental health than obesity itself. Therefore, it is essential to evaluate not only the physical but also the psychosocial aspects of obesity and understand the interrelationship between the two, i. e., the psychosomatic correlation. It is also important to adopt a psychosomatic approach in the treatment of obesity.</p>

    DOI: 10.15064/jjpm.64.6_516

    CiNii Research

  • Persistence of gut dysbiosis in individuals with anorexia nervosa

    Morisaki, Y; Miyata, N; Nakashima, M; Hata, T; Takakura, S; Yoshihara, K; Suematsu, T; Nomoto, K; Miyazaki, K; Tsuji, H; Sudo, N

    PLOS ONE   18 ( 12 )   e0296037   2023.12   ISSN:1932-6203

     More details

    Language:English   Publisher:PLoS ONE  

    Recent evidence suggests a crucial role of the gut microbiota in the pathogenesis of anorexia nervosa (AN). In this study, we carried out a series of multiple analyses of the gut microbiota of hospitalized individuals with AN over three months using 16S or 23S rRNA-targeted reverse transcription-quantitative polymerase chain reaction (PCR) technology (YIF-SCAN®), which is highly sensitive and enables the precise quantification of viable microorganisms. Despite the weight gain and improvements in psychological features observed during treatment, individuals with AN exhibited persistent gut microbial dysbiosis over the three-month duration. Principal component analysis further underscored the distinct microbial profile of individuals with AN, compared with that of age-matched healthy women at all time points. Regarding the kinetics of bacterial detection, the detection rate of Lactiplantibacillus spp. significantly increased after inpatient treatment. Additionally, the elevation in the Bifidobacterium counts during inpatient treatment was significantly correlated with the subsequent body weight gain after one year. Collectively, these findings suggest that gut dysbiosis in individuals with AN may not be easily restored solely through weight gain, highlighting the potential of therapeutic interventions targeting microbiota via dietary modifications or live biotherapeutics. Copyright:

    DOI: 10.1371/journal.pone.0296037

    Web of Science

    Scopus

    PubMed

  • Dietary supplementation with 1-kestose induces altered locomotor activity and increased striatal dopamine levels with a change in gut microbiota in male mice. Reviewed International journal

    Altaisaikhan A, Yoshihara K, Hata T, Miyata N, Asano Y, Suematsu T, Kadota Y, Sudo N.

    Physiol Rep.   2023.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.14814/phy2.15882.

  • Persistence of gut dysbiosis in individuals with anorexia nervosa. Reviewed International journal

    Morisaki Y, Miyata N, Nakashima M, Hata T, Takakura S, Yoshihara K, Suematsu T, Nomoto K, Miyazaki K, Tsuji H, Sudo N.

    PLoS One.   2023.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0296037.

  • Dietary supplementation with 1-kestose induces altered locomotor activity and increased striatal dopamine levels with a change in gut microbiota in male mice

    Altaisaikhan, A; Yoshihara, K; Hata, T; Miyata, N; Asano, Y; Suematsu, T; Kadota, Y; Sudo, N

    PHYSIOLOGICAL REPORTS   11 ( 23 )   e15882   2023.12   ISSN:2051-817X

     More details

    Language:English   Publisher:Physiological Reports  

    1-Kestose (KES), a dietary fiber and prebiotic carbohydrate, benefits various physiological functions. This study aimed to examine whether diets supplemented with KES over three consecutive generations could significantly affect some host physiological aspects, including behavioral phenotypes and gut microbial ecology. Mice that received KES-supplemented diets for three generations demonstrated increased activity compared with those fed diets lacking KES. Furthermore, the KES group showed increased striatal dopamine (DA) and serotonin (5-HT) levels. The observed increase in DA levels within the striatum was positively correlated with locomotor activity in the KES group but not in the control (CON) group. The α-diversities were significantly lower in the KES group compared to the CON group. The three-dimensional principal coordinate analysis revealed a substantial distinction between the KES and CON groups across each generation. At the genus level, most gut microbiota genera exhibited lower abundances in the KES group than in the CON group, except for Bifidobacteria and Akkermansia. Spearman's rank-order analysis indicated significant negative correlations between the striatal DA levels and α-diversity values. These findings suggest that prolonged supplementation with KES may stimulate increased locomotor activity along with elevated striatal DA levels, which are potentially associated with KES-induced alterations in the gut microbiota.

    DOI: 10.14814/phy2.15882

    Web of Science

    Scopus

    PubMed

  • Inadequate care and excessive overprotection during childhood are associated with the presence of Diabetes Mellitus in adulthood in a general Japanese population: a cross-sectional analysis from the Hisayama Study

    Shibata, M; Hosoi, M; Anno, K; Hirabayashi, N; Hirakawa, Y; Kawata, H; Iwaki, R; Sawamoto, R; Sudo, N; Ninomiya, T

    BMC ENDOCRINE DISORDERS   23 ( 1 )   253   2023.11   eISSN:1472-6823

     More details

    Language:English   Publisher:BMC Endocrine Disorders  

    Following publication of the original article [1], the authors reported an error in the number of participants in Fig. 2. The original Fig. 2 was: The updated Fig. 2 should read: The original article [1] has been updated.

    DOI: 10.1186/s12902-023-01513-0

    Web of Science

    Scopus

    PubMed

  • The relation between vaccination status and referral to a consultation-liaison psychiatry service for hospitalized patients with COVID-19

    Nishihara, T; Shibata, M; Ohashi, A; Hiyama, K; Yamashita, T; Kuroiwa, M; Sudo, N

    BIOPSYCHOSOCIAL MEDICINE   17 ( 1 )   40   2023.11   ISSN:1751-0759

     More details

    Language:English   Publisher:BioPsychoSocial Medicine  

    Background: Previous studies have shown that patients with Coronavirus Disease 2019 (COVID-19) are likely to be affected by delirium and other psychiatric complications. We aimed to evaluate the relation between COVID-19 vaccination status and referral of patients hospitalized with COVID-19 for consultation–liaison psychiatry services. Method: From the medical records used for this retrospective, single hospital-based study, 576 patients were identified who were over 18 years-of-age and hospitalized with a diagnosis of COVID-19 between March 2020 and March 2022. The data of 531 for whom the vaccine history was obtained from the medical records were available for analysis: 455 without and 76 with referral to consultation–liaison psychiatry. A history of COVID-19 vaccination at least two times was used in the analysis of the odds for referral to liaison psychiatric consultation: 95% confidence interval (CI) in multivariable logistic regression. The adjustment factors included sex, age, body mass index (BMI), severity of COVID-19, C-reactive protein level, medical history, and therapeutic factors such as the use of remdesivir, steroids, or mechanical ventilation. Results: The prevalence of psychiatric consultation was 14.3%. Patients without vaccination had a 7-times greater OR (95%CI:2.08–23.58) than vaccinated patients for a referral for consultation–liaison psychiatry services after adjusting for confounding factors. Conclusion: Non-vaccination was associated with a greater likelihood of referral for consultation–liaison psychiatry service among these hospitalized Japanese patients with COVID-19, even after adjusting for clinical and therapeutic factors. It is possible that vaccination greatly lessens the need for the referral of COVID-19 patients for consultation–liaison psychiatry services.

    DOI: 10.1186/s13030-023-00296-z

    Web of Science

    Scopus

    PubMed

  • The relation between vaccination status and referral to a consultation-liaison psychiatry service for hospitalized patients with COVID-19. Reviewed International journal

    Nishihara T, Shibata M, Ohashi A, Hiyama K, Yamashita T, Kuroiwa M, Sudo N.

    Biopsychosoc Med.   17 ( 1 )   40   2023.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13030-023-00296-z.

  • The relation between vaccination status and referral to a consultation-liaison psychiatry service for hospitalized patients with COVID-19(タイトル和訳中)

    Nishihara Tomoe, Shibata Mao, Ohashi Ayako, Hiyama Kazutoshi, Yamashita Takafumi, Kuroiwa Mika, Sudo Nobuyuki

    Biopsychosocial Medicine   17   1 of 7 - 7 of 7   2023.11

     More details

    Language:English   Publisher:(一社)日本心身医学会  

    2020年3月~2022年3月の一病院における18歳以上のCOVID-19入院患者576名を後ろ向きに検討した。ワクチン接種歴が判明した531名のうち76名がコンサルテーション・リエゾン精神科に紹介された。2回以上のワクチン接種歴を、紹介のオッズ解析に採用した。性別、年齢、BMI、COVID-19重症度、C反応性蛋白質、病歴および治療要因(レムデシビル、ステロイド、人工呼吸器)を調整因子とした。コンサルテーション・リエゾン精神科紹介率は14.3%であった。交絡因子を調整後に、接種歴のある患者と比べて接種歴のない患者のコンサルテーション・リエゾン精神科紹介のオッズ比は7.00であった。以上の結果から、ワクチン接種はCOVID-19入院患者のコンサルテーション・リエゾン精神科紹介の必要を減らすと考えられた。

  • Psychological characteristics associated with the brain volume of patients with fibromyalgia

    Izuno, S; Yoshihara, K; Hosoi, M; Eto, S; Hirabayashi, N; Todani, T; Gondo, M; Hayaki, C; Anno, K; Hiwatashi, A; Sudo, N

    BIOPSYCHOSOCIAL MEDICINE   17 ( 1 )   36   2023.10   ISSN:1751-0759

     More details

    Language:English   Publisher:BioPsychoSocial Medicine  

    Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with psychiatric symptoms such as anxiety and depression. It has been reported that FM patients engage in pain catastrophizing. In this study, we investigated characteristics of the brain volume of female FM patients and the association between psychological indices and brain volume. Thirty-nine female FM patients and 25 female healthy controls (HCs) were recruited for the study, and five FM patients were excluded due to white matter lesions. The following analyses were performed: (1) T1-weighted MRI were acquired for 34 FM patients (age 41.6 ± 7.4) and 25 HCs (age 39.5 ± 7.4). SPM12 was used to compare their gray and white matter volumes. (2) Data from anxiety and depression questionnaires (State-Trait Anxiety Inventory and Hospital Anxiety and Depression Scale), the Pain Catastrophizing Scale (subscales rumination, helplessness, magnification), and MRI were acquired for 34 FM patients (age 41.6 ± 7.4). Correlation analysis was done of the psychological indices and brain volume. We found that (1) The white matter volume of the temporal pole was larger in the FM patient group than in the HC group. (2) Correlation analysis of the psychological indices and gray matter volume showed a negative correlation between trait anxiety and the amygdala. For the white matter volume, positive correlations were found between depression and the brainstem and between magnification and the postcentral gyrus. Changes in the brain volume of female FM patients may be related to anxiety, depression, and pain catastrophizing.

    DOI: 10.1186/s13030-023-00293-2

    Web of Science

    Scopus

    PubMed

  • Inadequate care and excessive overprotection during childhood are associated with the presence of diabetes mellitus in adulthood in a general Japanese population: a cross-sectional analysis from the Hisayama Study

    Shibata, M; Hosoi, M; Anno, K; Hirabayashi, N; Hirakawa, Y; Kawata, H; Iwaki, R; Sawamoto, R; Sudo, N; Ninomiya, T

    BMC ENDOCRINE DISORDERS   23 ( 1 )   222   2023.10   eISSN:1472-6823

     More details

    Language:English   Publisher:BMC Endocrine Disorders  

    Objective: To investigate associations between parenting styles during childhood and diabetes in adulthood in a Japanese community. Methods: In 2011, 710 community-dwelling Japanese residents aged ≥ 40 years were assessed for the presence of diabetes and for their perceptions of the parenting style of their parents, as measured using the “care” and “overprotection” scales of the Parental Bonding Instrument. Care and overprotection scores for each parent were dichotomized by age-specific median values. Diabetes mellitus was defined as a fasting plasma glucose level of ≥ 7.0 mmol/L, a 2-h post-loaded glucose level of ≥ 11.1 mmol/L, HbA1c ≥ 6.5%, and/or the current use of insulin or oral glucose-lowering agents. The odds ratios (ORs) for prevalent diabetes were calculated using a logistic regression model. Results: The prevalence of diabetes was 14.9%. Subjects with a high paternal overprotection score had a significantly greater likelihood of prevalent diabetes than those with a low paternal overprotection score after adjusting for confounders (OR 1.71, 95% confidence interval [CI] 1.06–2.77), while there was no significant association between paternal care and diabetes. Additionally, the multivariable-adjusted ORs for the presence of diabetes were significantly higher in subjects with a low maternal care score (OR 1.61, 95%CI 1.00–2.60) or in subjects with a high maternal overprotection score (OR 1.73, 95%CI 1.08–2.80). Moreover, the subjects with a low care score and high overprotection score for both their father and mother had a significantly higher multivariable-adjusted OR of diabetes than those with a high care score and low overprotection score for both parents (OR 2,12, 95%CI 1.14–3.95). Conclusions: This study suggests that inadequate care and excessive overprotection during childhood may contribute to the development of diabetes in adulthood.

    DOI: 10.1186/s12902-023-01474-4

    Web of Science

    Scopus

    PubMed

  • Psychological characteristics associated with the brain volume of patients with fibromyalgia. Reviewed International journal

    Izuno S, Yoshihara K, Hosoi M, Eto S, Hirabayashi N, Todani T, Gondo M, Hayaki C, Anno K, Hiwatashi A, Sudo N.

    Biopsychosoc Med.   17 ( 1 )   36   2023.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13030-023-00293-2.

  • Inadequate care and excessive overprotection during childhood are associated with the presence of diabetes mellitus in adulthood in a general Japanese population: a cross-sectional analysis from the Hisayama Study. Reviewed International journal

    Shibata M, Hosoi M, Anno K, Hirabayashi N, Hirakawa Y, Kawata H, Iwaki R, Sawamoto R, Sudo N, Ninomiya T.

    BMC Endocr Disord.   23 ( 1 )   222   2023.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12902-023-01474-4.

  • 線維筋痛症患者の脳容積と関連する心理的特性(Psychological characteristics associated with the brain volume of patients with fibromyalgia)

    Izuno Satoshi, Yoshihara Kazufumi, Hosoi Masako, Eto Sanami, Hirabayashi Naoki, Todani Tae, Gondo Motoharu, Hayaki Chie, Anno Kozo, Hiwatashi Akio, Sudo Nobuyuki

    Biopsychosocial Medicine   17   1 of 10 - 10 of 10   2023.10

     More details

    Language:English   Publisher:(一社)日本心身医学会  

    線維筋痛症(FM)の女性患者34名および女性健常対照25名を対象に、T1強調MRIと画像解析ソフトウェアSPM12を用いて灰白質および白質容積を測定した。FM患者の状態-特性不安尺度(STAI)、病院不安抑鬱尺度(HADS)および痛みの破局的思考尺度(PCS)を評価した。FM患者群の側頭極白質容積は対照群と比べて大きかった。心理学的指標と灰白質容積の相関分析の結果、特性不安と扁桃体の間に負相関がみられた。白質容積に関して、HADSで評価される抑鬱と脳幹の間、およびPCSで評価される拡大視と中心後回の間に正相関がみられた。以上の結果から、女性FM患者の脳容積変化が不安、抑鬱および痛みの破局化と関連すると考えられた。

  • Alexithymia characteristics are associated with salience network activity in healthy participants: an arterial spin labeling study

    Motomura, Y; Fukuzaki, A; Eto, S; Hirabayashi, N; Gondo, M; Izuno, S; Togao, O; Yamashita, K; Kikuchi, K; Sudo, N; Yoshihara, K

    JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY   42 ( 1 )   18   2023.9   ISSN:1880-6805

     More details

    Language:English   Publisher:Journal of Physiological Anthropology  

    Background: Alexithymia, a personality trait characterized by difficulties in identifying and expressing their emotions despite having a range of emotional experiences, can impact individuals’ stress coping mechanisms. While many studies have investigated brain functions associated with specific tasks in relation to emotion processing, research focusing on resting-state brain functions has been limited. Thus, the aim of this study was to investigate the relationship between alexithymia and brain function by analyzing arterial spin labeling (ASL) data obtained during the resting state. Methods: A brain structural and functional imaging study was conducted on 42 healthy adult men and women using ASL and the 20-item Toronto Alexithymia Scale (TAS-20) questionnaire survey. Cerebral blood flow and functional connectivity values were calculated for regions of interest in the default mode network, saliency network, and central executive network from the ASL data. Correlation analysis was performed with TAS20 scores, and partial correlation analysis was conducted to control for anxiety and depression. Results: The functional connectivity analysis revealed a negative correlation between the functional connectivity of the right insular cortex and left anterior cingulate cortex and the total score of TAS, as well as difficulty identifying feelings and difficulty describing feeling subscores, indicating that the higher the scores, the weaker the functional connectivity between these regions (T = -3.830, p = 0.0013, R = -0.5180). This correlation remained significant even after controlling for anxiety and depression using partial correlation analysis. Conclusion: The present study revealed differences in the activity of the Saliency Network at rest as measured by ASL, which were independent of anxiety and depression, and varied depending on the severity of alexithymia. This functional change may underlie the neural basis of decreased emotional processing observed in alexithymia. These findings may contribute to the elucidation of the neural mechanisms of alexithymia, which can lead to social impairments, and suggest the usefulness of ASL measurement as a biomarker of alexithymia.

    DOI: 10.1186/s40101-023-00336-1

    Web of Science

    Scopus

    PubMed

  • Alexithymia characteristics are associated with salience network activity in healthy participants: an arterial spin labeling study. Reviewed International journal

    Motomura Y, Fukuzaki A, Eto S, Hirabayashi N, Gondo M, Izuno S, Togao O, Yamashita K, Kikuchi K, Sudo N, Yoshihara K.

    J Physiol Anthropol.   42 ( 1 )   18   2023.9

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40101-023-00336-1.

  • 健常者における失感情症の特徴はsalience network活動性と関連する 動脈スピンラベリング研究(Alexithymia characteristics are associated with salience network activity in healthy participants: an arterial spin labeling study)

    Motomura Yuki, Fukuzaki Ayaka, Eto Sanami, Hirabayashi Naoki, Gondo Motoharu, Izuno Satoshi, Togao Osamu, Yamashita Koji, Kikuchi Kazufumi, Sudo Nobuyuki, Yoshihara Kazufumi

    Journal of Physiological Anthropology   42   1 of 13 - 13 of 13   2023.9   ISSN:1880-6791

     More details

    Language:English   Publisher:(一社)日本生理人類学会  

    失感情症と脳機能の関係について安静時に取得した動脈スピンラベリング(ASL)データの解析による検討を行った。健常成人42人(男性14人、女性28人、平均31.2±9.5歳)を対象として、ASLと20-item Toronto Alexithymia Scale(TAS-20)アンケート調査を用いて脳の構造及び機能イメージング研究を行った。ASLデータから、デフォルトモードネットワーク、salience network及びセントラルエグゼクティブネットワークにおける関心領域に対する脳血流及び機能的結合の値を算出した。機能的結合分析により、右島皮質及び左前帯状皮質の機能的結合と、TAS-20のトータルスコア、感情を特定することの困難さ、感情を語ることの困難さのサブスコアに負の相関がみられた。これらのスコアが高いほどこれらの領域間の機能的結合は弱くなった。この相関は偏相関分析を用いて不安及び抑鬱を調整した後でも有意であった。

  • Economic costs for outpatient treatment of eating disorders in Japan

    Kurisu, K; Nohara, N; Inada, S; Otani, M; Noguchi, H; Endo, Y; Sato, Y; Fukudo, S; Nakazato, M; Yamauchi, T; Harada, T; Inoue, K; Hata, T; Takakura, S; Sudo, N; Iida, N; Mizuhara, Y; Wada, Y; Ando, T; Yoshiuchi, K

    JOURNAL OF EATING DISORDERS   11 ( 1 )   136   2023.8   ISSN:2050-2974

     More details

    Language:English   Publisher:Journal of Eating Disorders  

    Background: Few studies have examined the economic costs of outpatient care for eating disorders in Japan. This study aimed to clarify the reimbursement for outpatient treatment of eating disorders and compare the costs between the departments of Psychosomatic Medicine and Psychiatry in Japan. Method: A multicenter, prospective, observational study of patients with an eating disorder was conducted in the Psychosomatic Medicine departments of three centers and the Psychiatry departments of another three centers in Japan. We analyzed medical reimbursement for an outpatient revisit, time of clinical interviews, and the treatment outcome measured by the Eating Disorder Examination Questionnaire (EDE-Q) global scores and body mass index (BMI) at 3 months. Multivariate linear regression models were performed to adjust for covariates. Results: This study included 188 patients in the Psychosomatic Medicine departments and 68 in the Psychiatry departments. The average reimbursement cost for an outpatient revisit was 4670 yen. Even after controlling for covariates, the Psychosomatic Medicine departments had lower reimbursement points per minute of interviews than the Psychiatry departments (coefficient = − 23.86; 95% confidence interval = − 32.09 to − 15.63; P < 0.001). In contrast, EDE-Q global scores and BMI at 3 months were not significantly different between these departments. Conclusions: This study clarifies the economic costs of treating outpatients with eating disorders in Japan. The medical reimbursement points per interview minute were lower in Psychosomatic Medicine departments than in Psychiatry departments, while there were no apparent differences in the treatment outcomes. Addressing this issue is necessary to provide an adequate healthcare system for patients with eating disorders in Japan.

    DOI: 10.1186/s40337-023-00864-2

    Web of Science

    Scopus

    PubMed

  • Economic costs for outpatient treatment of eating disorders in Japan. Reviewed International journal

    Kurisu K, Nohara N, Inada S, Otani M, Noguchi H, Endo Y, Sato Y, Fukudo S, Nakazato M, Yamauchi T, Harada T, Inoue K, Hata T, Takakura S, Sudo N, Iida N, Mizuhara Y, Wada Y, Ando T, Yoshiuchi K.

    J Eat Disord.   11 ( 1 )   136   2023.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40337-023-00864-2.

  • Assessment of nutritional status and psychopathology in the treatment of eating disorders with different duration of illness

    Takakura, S; Morita, C; Miyata, N; Hata, T; Sudo, N

    ANNALS OF NUTRITION AND METABOLISM   79   78 - 78   2023.8   ISSN:0250-6807 eISSN:1421-9697

     More details

  • A nationwide questionnaire survey of physicians regarding the impact of the COVID-19 pandemic on patients and treatment system of psychosomatic medicine. Reviewed International journal

    Yamanaka Y, Yoshiuchi K, Kubo C, Fukudo S; Japanese Society of Psychosomatic Medicine.

    Biopsychosoc Med.   17 ( 1 )   21   2023.6

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13030-023-00279-0.

  • Effects of integrated hospital treatment on the default mode, salience, and frontal-parietal networks in anorexia nervosa: A longitudinal resting-state functional magnetic resonance imaging study

    Gondo, M; Kawai, K; Moriguchi, Y; Hiwatashi, A; Takakura, S; Yoshihara, K; Morita, C; Yamashita, M; Eto, S; Sudo, N

    PLOS ONE   18 ( 5 )   e0283318   2023.5   ISSN:1932-6203

     More details

    Language:English   Publisher:PLoS ONE  

    The psychopathology of patients with anorexia nervosa has been hypothesized to involve inappropriate self-referential processing, disturbed interoceptive awareness, and excessive cognitive control, including distorted self-concern, disregard of their own starvation state, and extreme weight-control behavior. We hypothesized that the resting-state brain networks, including the default mode, salience and frontal-parietal networks, might be altered in such patients, and that treatment might normalize neural functional connectivity, with improvement of inappropriate self-cognition. We measured resting-state functional magnetic resonance images from 18 patients with anorexia nervosa and 18 healthy subjects before and after integrated hospital treatment (nourishment and psychological therapy). The default mode, salience, and frontal-parietal networks were examined using independent component analysis. Body mass index and psychometric measurements significantly improved after treatment. Before treatment, default mode network functional connectivity in the retrosplenial cortex and salience network functional connectivity in the ventral anterior insula and rostral anterior cingulate cortex were decreased in anorexia nervosa patients compared with those in controls. Interpersonal distrust was negatively correlated with salience network functional connectivity in the rostral anterior cingulate cortex. Default mode network functional connectivity in the posterior insula and frontal-parietal network functional connectivity in the angular gyrus were increased in anorexia nervosa patients compared with those in controls. Comparison between pre- and post-treatment images from patients with anorexia nervosa exhibited significant increases in default mode network functional connectivity in the hippocampus and retrosplenial cortex, and salience network functional connectivity in the dorsal anterior insula following treatment. Frontal-parietal network functional connectivity in the angular cortex showed no significant changes. The findings revealed that treatment altered the functional connectivity in several parts of default mode and salience networks in patients with anorexia nervosa. These alterations of neural function might be associated with improvement of self-referential processing and coping with sensations of discomfort following treatment for anorexia nervosa.

    DOI: 10.1371/journal.pone.0283318

    Web of Science

    Scopus

    PubMed

  • A multi-center, randomized, parallel-group study to compare the efficacy of enhanced cognitive behavior therapy (CBT-E) with treatment as usual (TAU) for anorexia nervosa: study protocol

    Nohara, N; Yamanaka, Y; Matsuoka, M; Yamazaki, T; Kawai, K; Takakura, S; Sudo, N; Ando, T; Matsuyama, Y; Byrne, S; Grave, RD; Cooper, Z; Yoshiuchi, K

    BIOPSYCHOSOCIAL MEDICINE   17 ( 1 )   20   2023.5   ISSN:1751-0759

     More details

    Language:English   Publisher:BioPsychoSocial Medicine  

    Background: The superiority of Enhanced Cognitive Behavior Therapy (CBT-E) with regard to weight gain and improvement of psychopathology of eating disorders for patients with anorexia nervosa (AN) over other psychotherapies and treatment as usual (TAU) has not been demonstrated in randomized controlled trials (RCTs). However, a previous RCT showed that patients with AN whose baseline body mass index (BMI) was less than 17.5 kg/m2 gained more weight when treated with CBT-E than with other psychotherapies. The aim of the study is to compare the efficacy of CBT-E and TAU for patients with AN. It was hypothesized that CBT-E would be superior to TAU, at least in terms of weight gain, as most patients with AN are likely to have a BMI lower than 17.5 kg/m2. Methods/design: A randomized parallel-group multicenter trial will be conducted in three teaching hospitals in Japan between January 2023 and March 2026. Patients with DSM-5 AN, aged 16 years and older, with a BMI equal to or above 14.0 and below 18.5 will be eligible to participate. 56 patients will be randomly and evenly assigned to two intervention groups (CBT-E and TAU). Those assigned to CBT-E will be offered 25–40 sessions in accordance with their initial BMI. Patients assigned to TAU will have at least one session every 2 weeks, with the number of sessions and treatment period not fixed in advance. The primary outcome is BMI at 40 weeks after treatment initiation. The secondary outcomes are the results from the Japanese version of the Eating Disorder Examination Questionnaire and Clinical Impairment Assessment questionnaire to measure eating disorder psychopathology and psychological impairment. The follow-up assessment will be performed 6 months after the 40-week assessment. Discussion: This multi-center randomized controlled study will probably evaluate the efficacy of CBT-E compared with TAU for patients with more severe AN than in previous studies since Japanese patients are likely to have a lower BMI than those in Western countries. While it may be difficult to generalize the results of a study conducted in Japan, it would be valuable to clarify the efficacy of CBT-E as a treatment package. Trial registration: UMIN, UMIN000048847. Registered 12 Sep 2022.

    DOI: 10.1186/s13030-023-00277-2

    Web of Science

    Scopus

    PubMed

  • 特集 脳腸相関UPDATE-疾患の予防と健康長寿のための食・栄養・腸環境 (Part 2)脳腸相関と疾患 うつ

    須藤 信行

    臨床栄養   142 ( 6 )   863 - 869   2023.5   ISSN:04851412

     More details

    Publisher:医歯薬出版(株)  

    DOI: 10.32118/j01532.2023220961

    CiNii Research

  • Effects of integrated hospital treatment on the default mode, salience, and frontal-parietal networks in anorexia nervosa: A longitudinal resting-state functional magnetic resonance imaging study. Reviewed International journal

    Gondo M, Kawai K, Moriguchi Y, Hiwatashi A, Takakura S, Yoshihara K, Morita C, Yamashita M, Eto S, Sudo N.

    PLoS One.   2023.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0283318.

  • A multi-center, randomized, parallel-group study to compare the efficacy of enhanced cognitive behavior therapy (CBT-E) with treatment as usual (TAU) for anorexia nervosa: study protocol. Reviewed International journal

    Nohara N, Yamanaka Y, Matsuoka M, Yamazaki T, Kawai K, Takakura S, Sudo N, Ando T, Matsuyama Y, Byrne S, Dalle Grave R, Cooper Z, Yoshiuchi K.

    Biopsychosoc Med.   2023.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13030-023-00277-2.

  • Differences in the presentation of COVID-19-related psychosocial stress and general psychological distress and the relation between the number of care days and these symptoms among Japanese ward staff working exclusively with COVID-19 and support staff

    Nishihara, T; Yoshihara, K; Ohashi, A; Kuroiwa, M; Sudo, N

    BIOPSYCHOSOCIAL MEDICINE   17 ( 1 )   17   2023.4   ISSN:1751-0759

     More details

    Language:English   Publisher:BioPsychoSocial Medicine  

    Background: Psychological distress has been frequently observed in frontline healthcare workers under stress during the coronavirus disease 2019 (COVID-19) epidemic; however, it is unclear if there are differences in the stress and symptoms experienced by staff members who work exclusively in a COVID-19 ward and support staff temporarily deployed to a COVID-19 ward. The present study investigated psychosocial stress specific to the care for patients with COVID-19 and psychological distress among ward staff working exclusively with COVID-19 and temporary support staff. Methods: The participants were full-time nurses and doctors working in COVID-19 wards or the ICU who provided face-to-face care to patients with COVID-19 during the COVID-19 outbreak in February of 2021. The data of 67 staff members (21 exclusively working with Covid-19 patients (group A) and 46 in the temporary support group (group B)) was available for study. Psychosocial stress specific to healthcare professionals during this COVID-19 outbreak (Tokyo Metropolitan Distress Scale for Pandemic [TMDP]) and general psychological distress (K6) were assessed. Results: The K6 score was significantly lower in group B than in group A (p =.006), but no significant difference was found in the total score of TMDP or its subscales. Positive correlations were found between TMDP and K6 for group B (p =.011), as was the number of days of care on TMDP-social (rs =.456, p =.001). Conclusion: Even though support staff members experienced lower psychological distress than staff working exclusively with COVID-19, COVID-19-related psychosocial stress specific to HCWs was comparable. The support staff also presented psychological distress associated with psychosocial stress specific to healthcare professionals during this COVID-19 outbreak, and the COVID-19-related social stress was enhanced as the number of working days increased. Our results show that all staff, not only those working exclusively with COVID-19 patients but also other support staff should be provided with care focusing on COVID-19-related psychosocial occupational stress.

    DOI: 10.1186/s13030-023-00272-7

    Web of Science

    Scopus

    PubMed

  • Differences in the presentation of COVID-19-related psychosocial stress and general psychological distress and the relation between the number of care days and these symptoms among Japanese ward staff working exclusively with COVID-19 and support staff. Reviewed International journal

    Nishihara T, Yoshihara K, Ohashi A, Kuroiwa M, Sudo N.

    Biopsychosoc Med.   2023.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13030-023-00272-7.

  • Family dysfunction is associated with chronic pain in a community-dwelling Japanese population: The Hisayama study. Reviewed International journal

    Saito T, Shibata M, Hirabayashi N, Honda T, Morisaki Y, Anno K, Sudo N, Hosoi M, Ninomiya T.

    Eur J Pain.   4   518 - 529   2023.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ejp.2076.

  • Family dysfunction is associated with chronic pain in a community-dwelling Japanese population: The Hisayama study

    Saito, T; Shibata, M; Hirabayashi, N; Honda, T; Morisaki, Y; Anno, K; Sudo, N; Hosoi, M; Ninomiya, T

    EUROPEAN JOURNAL OF PAIN   27 ( 4 )   518 - 529   2023.4   ISSN:1090-3801 eISSN:1532-2149

     More details

    Language:English   Publisher:European Journal of Pain (United Kingdom)  

    Background: Poor family functioning has been reported to be associated with the severity of chronic pain in outpatients, but the association has not been fully addressed in general populations. The present study aimed to examine the association between family dysfunction levels and the presence of chronic pain in a community-dwelling Japanese population. Methods: A total of 2598 participants aged ≥40 years were classified as having healthy, borderline or unhealthy family functioning. Chronic pain was defined as subjective pain for three months or longer, and further classified by pain intensity, the number of chronic pain sites, pain duration and the extent of pain spread. A logistic regression model was used to compute the odds ratios (ORs) for chronic pain outcomes. Results: The prevalence of chronic pain was 49%. The age- and sex-adjusted prevalence of total and severe chronic pain were increased significantly with increasing family dysfunction levels (all p for trend <0.01). After adjusting for sociodemographic, physical, social and family structure factors, the ORs (95% confidence intervals [CI]) for having chronic pain among borderline and unhealthy groups were 1.20 (1.01–1.44) and 1.43 (1.15–1.79), respectively, as compared with a healthy family function group. The association was stronger among people who were employed and those who were living with their children. In addition, the ORs for severe chronic pain increased significantly with increasing levels of family dysfunction. Conclusions: The family dysfunction level was positively associated with the presence as well as the severity of chronic pain in a community-dwelling population. Significance: A biopsychosocial burden due to family relationships could worsen the clinical presentation of pain. Social support or family therapy for dysfunctional families would be a potential initiative for the prevention or management of chronic pain.

    DOI: 10.1002/ejp.2076

    Web of Science

    Scopus

    PubMed

  • COVID-19関連心理社会的ストレスとgeneral psychological distress表出の相違および日本人のCOVID-19専属病棟スタッフと支援スタッフにおけるケア日数と症状との関係(Differences in the presentation of COVID-19-related psychosocial stress and general psychological distress and the relation between the number of care days and these symptoms among Japanese ward staff working exclusively with COVID-19 and support staff)

    Nishihara Tomoe, Yoshihara Kazufumi, Ohashi Ayako, Kuroiwa Mika, Sudo Nobuyuki

    Biopsychosocial Medicine   17   1 of 7 - 7 of 7   2023.4

     More details

    Language:English   Publisher:(一社)日本心身医学会  

    COVID-19患者のケアに特異的な心理社会的ストレス、COVID-19専属病棟従事者と支援従事者の精神的苦痛について調査した。被験者は2021年2月のCOVID-19流行下におけるCOVID-19病棟の看護師と医師で、専任従事者67名(A群)と一時的なサポート従事者46名(B群)であった。COVID-19流行における医療従事者に特有な心理社会的ストレス(Tokyo Metropolitan Distress Scale for Pandemic[TMDP])とgeneral psychological distress(K6)を評価した。K6スコアはA群よりもB群で有意に低かったが、TMDPの総合スコアと下位尺度で有意差はなかった。B群ではTMDPとK6に正相関が認められ、TMDP-社会項目に対するケア日数でも正相関が認められた。COVID-19専属従事者よりも支援従事者のほうが精神的苦痛は弱かったが、心理社会的ストレスはほぼ同等であった。支援従事者でも精神的苦痛が認められ、従事日数増加とともに社会的ストレスが増大した。

  • Occupational stress, psychological distress, physical symptoms, and their interrelationships among frontline nurses caring for COVID-19 patients in Japan

    Nishihara, T; Yoshihara, K; Ohashi, A; Kuroiwa, M; Sudo, N

    MEDICINE   101 ( 48 )   e31687   2022.12   ISSN:0025-7974 eISSN:1536-5964

     More details

    Language:English   Publisher:Medicine (United States)  

    This study aimed to identify occupational stress, psychosomatic symptoms, psychological distress, and their correlations among frontline nurses during and after the first peak of the coronavirus disease 2019 (COVID-19) outbreak in Japan. Sixteen frontline nurses, aged 25 to 52 years, working in a ward with COVID-19 patients participated in this study. Two months after the peak of the first wave of the COVID-19 outbreak in Japan, the COVID-19-related occupational stress scale (COS; questionnaire items: fear of infection and increased workload) and physical symptom scale (PS; questionnaire items: gastrointestinal symptoms, pain, appetite loss, and insomnia) were assessed. The degree of general psychological distress was evaluated using the 6-item Kessler Scale (K6). Simultaneously, participants were asked to recall their condition during the peak period of the first wave and rate it using the same scale. K6 was positively correlated with COS and PS during the peak period (rs=0.574, P=.020 and rs=0.587, P=.017, respectively). Increased workload was positively correlated with the K6 score both during and after the peak period (rs=0.869, P<.001 and rs=0.732, P = <.001, respectively) and was positively correlated with insomnia during the peak period (rs=0.498, P<.05). The COS, PS, and K6 scores during the peak period were significantly higher than those after the peak period. Psychological distress at the peak was associated with PS and occupational stress. An increased workload during peak periods can cause psychological distress and insomnia. The occupational stress, PS, and psychological distress of nurses working in COVID-19 wards improved after the peak of COVID-19.

    DOI: 10.1097/MD.0000000000031687

    Web of Science

    Scopus

    PubMed

  • Occupational stress, psychological distress, physical symptoms, and their interrelationships among frontline nurses caring for COVID-19 patients in Japan. Reviewed International journal

    Nishihara T, Yoshihara K, Ohashi A, Kuroiwa M, Sudo N.

    Medicine (Baltimore).   2022.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MD.0000000000031687.

  • Cardiopulmonary exercise testing for patients with anorexia nervosa: a case-control study. Reviewed International journal

    Yamashita M, Kawai K, Toda K, Aso C, Suematsu T, Yokoyama H, Hata T, Takakura S, Sudo N.

    Eat Weight Disord.   8   3553 - 3560   2022.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s40519-022-01492-6.

  • Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice

    Homma T., Nagata N., Hashimoto M., Iwata-Yoshikawa N., Seki N.M., Shiwa-Sudo N., Ainai A., Dohi K., Nikaido E., Mukai A., Ukai Y., Nakagawa T., Shimo Y., Maeda H., Shirai S., Aoki M., Sonoyama T., Sato M., Fumoto M., Nagira M., Nakata F., Hashiguchi T., Suzuki T., Omoto S., Hasegawa H.

    Scientific Reports   12 ( 1 )   2022.12

     More details

    Publisher:Scientific Reports  

    Vaccines that efficiently target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease (COVID-19), are the best means for controlling viral spread. This study evaluated the efficacy of the COVID-19 vaccine S-268019-b, which comprises the recombinant full-length SARS-CoV-2 spike protein S-910823 (antigen) and A-910823 (adjuvant). In addition to eliciting both Th1-type and Th2-type cellular immune responses, two doses of S-910823 plus A-910823 induced anti-spike protein IgG antibodies and neutralizing antibodies against SARS-CoV-2. In a SARS-CoV-2 challenge test, S-910823 plus A-910823 mitigated SARS-CoV-2 infection-induced weight loss and death and inhibited viral replication in mouse lungs. S-910823 plus A-910823 promoted cytokine and chemokine at the injection site and immune cell accumulation in the draining lymph nodes. This led to the formation of germinal centers and the induction of memory B cells, antibody-secreting cells, and memory T cells. These findings provide fundamental property of S-268019-b, especially importance of A-910823 to elicit humoral and cellular immune responses.

    DOI: 10.1038/s41598-022-25418-5

    Scopus

  • Chronic Pain Acceptance Questionnaire日本語版(CPAQ-J)の作成と信頼性・妥当性の検討

    安野 広三, 岩城 理恵, 村上 匡史, 藤本 晃嗣, 田中 佑, 早木 千絵, 須藤 信行, 細井 昌子

    慢性疼痛   41 ( 1 )   83 - 90   2022.12   ISSN:1340-2331

     More details

    Language:Japanese   Publisher:日本慢性疼痛学会  

    【背景】「慢性疼痛のアクセプタンス」は慢性疼痛の理解や治療のための重要な概念とされている。その測定にはChronic Pain Acceptance Questionnaireが最も使用されている。本研究の目的はCPAQ日本語版(CPAQ-J)の作成,その妥当性の検討であった。【方法】慢性疼痛患者243人を対象とし,CPAQ-Jおよび痛みの強度,機能障害,不安,抑うつ,痛みの破局化,生活の質,生活満足度につき回答してもらった。【結果】CPAQ-Jはスクリープロット,主因子法により英語原版と同様の2因子構造を示し,十分な内的整合性(Cronbach α係数0.83)と再検査信頼性(級内相関係数0.88)が示された。また,痛みの強度,機能障害,不安,抑うつ,痛みの破局化,生活の質,生活満足度と有意な関連を認めた。【結論】本研究でCPAQ-Jは我が国の慢性疼痛患者において,十分な信頼性と妥当性が示された。(著者抄録)

  • Cardiopulmonary exercise testing for patients with anorexia nervosa: a case-control study

    Yamashita, M; Kawai, K; Toda, K; Aso, C; Suematsu, T; Yokoyama, H; Hata, T; Takakura, S; Sudo, N

    EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY   27 ( 8 )   3553 - 3560   2022.12   ISSN:1124-4909 eISSN:1590-1262

     More details

    Language:English   Publisher:Eating and Weight Disorders  

    Purpose: Patients with anorexia nervosa (AN) require appropriate nutrient therapy and physical activity management. Eating disorder treatment guidelines do not include safe, evidence-based intensity criteria for exercise. This study used cardiopulmonary exercise testing (CPX) to evaluate the exercise tolerance of patients with AN. Methods: CPX was performed with 14 female patients with AN admitted to a specialized eating disorder unit between 2015 and 2019. Their anaerobic threshold (AT) was determined by assessing their exercise tolerance using CPX and compared with 14 healthy controls (HC). The metabolic equivalents (AT-METS) were compared when AT was reached. We examined factors related to AT (AN-AT) in the AN group, including age, body mass index (BMI), previous lowest weight, minimum BMI, past duration of BMI < 15, exercise history, and ΔHR (heart rate at the AT—resting heart rate). Results: The AT of the AN group (BMI: 15.7 [Mean] ± 1.8 standard deviation [SD]) was significantly lower than that of the HC group (BMI: 19.7 ± 1.8) (AN: 10.0 ± 1.8 vs. HC: 15.2 ± 3.0 ml/kg/min, P < 0.001). AT-METS was also significantly lower in the AN group than in the HC group (AN: 2.9 ± 0.52 vs. HC: 4.4 ± 0.91, P < 0.001). AN-AT was highly influenced by ΔHR. Conclusions: This study showed that AT and AT-METS were lower in patients with AN than in HC. Patients with AN should be prescribed light-intensity aerobic exercise, and the current findings may help develop future physical management guidelines for patients with AN. Level of evidence: III: Evidence obtained from case–control analytic studies.

    DOI: 10.1007/s40519-022-01492-6

    Web of Science

    Scopus

    PubMed

  • 心理検査のフィードバックと自律訓練法が不眠を合併した書痙に有効であった一例

    永江 悠子, 吉原 一文, 富岡 光直, 宮田 典幸, 須藤 信行

    日本心療内科学会誌   26 ( 別冊 )   116 - 116   2022.11   ISSN:1342-9558

     More details

    Language:Japanese   Publisher:(NPO)日本心療内科学会  

    researchmap

  • Association between chronic low back pain and regional brain atrophy in a Japanese older population: the Hisayama Study

    Asada, M; Shibata, M; Hirabayashi, N; Ohara, T; Furuta, Y; Nakazawa, T; Honda, T; Hata, J; Hosoi, M; Sudo, N; Yamaura, K; Ninomiya, T

    PAIN   163 ( 11 )   2185 - 2193   2022.11   ISSN:0304-3959 eISSN:1872-6623

     More details

    Language:English   Publisher:Pain  

    Chronic low back pain (CLBP) is the leading cause of years lived with disability. Recently, it has been reported that CLBP is associated with alterations in the central nervous system. The present study aimed to investigate the association between CLBP and regional brain atrophy in an older Japanese population. A total of 1106 community-dwelling participants aged ≥65 years underwent brain magnetic resonance imaging scans and a health examination in 2017 to 2018. We used the FreeSurfer software for the analysis of brain magnetic resonance imaging. Chronic pain was defined as subjective pain for ≥3 months. Participants were divided into 3 groups according to the presence or absence of chronic pain and the body part that mainly suffered from pain: a "no chronic pain (NCP)" group (n = 541), "CLBP" group (n = 189), and "chronic pain in body parts other than the lower back (OCP)" group (n = 376). The brain volumes of the ventrolateral and dorsolateral prefrontal cortex, the posterior cingulate gyrus, and the amygdala were significantly lower in the CLBP group than in the NCP group after adjustment for sociodemographic, physical, and lifestyle factors and depressive symptoms. In addition, the left superior frontal gyrus was identified as a significant cluster by the Query, Design, Estimate, Contrast interface. There were no significant differences in the brain volumes of pain-related regions between the NCP and the OCP groups. The present study suggests that CLBP is associated with lower brain volumes of pain-related regions in a general older population of Japanese.

    DOI: 10.1097/j.pain.0000000000002612

    Web of Science

    Scopus

    PubMed

  • 自律訓練法が耳鳴症状に効果的であった一例

    富岡 光直, 吉原 一文, 永江 悠子, 須藤 信行

    日本心療内科学会誌   26 ( 別冊 )   135 - 135   2022.11   ISSN:1342-9558

     More details

    Language:Japanese   Publisher:(NPO)日本心療内科学会  

    researchmap

  • Factors associated with the improvement of body image dissatisfaction of female patients with overweight and obesity during cognitive behavioral therapy

    Yokoyama, H; Nozaki, T; Nishihara, T; Sawamoto, R; Komaki, G; Sudo, N

    FRONTIERS IN PSYCHIATRY   13   1025946   2022.10   ISSN:1664-0640

     More details

    Language:English   Publisher:Frontiers in Psychiatry  

    Background: Cognitive behavioral therapy (CBT) has become one of the most commonly used psychotherapeutic treatments for obesity. It stems from CBT for bulimia nervosa and binge eating disorder, which focuses on amelioration of the eating behavior and body image dissatisfaction (BID), but usually does not focus on weight loss. In contrast, CBT for obesity focuses on weight loss, as well as eating behavior and BID. It is at present unclear whether the improvement of BID during CBT for obesity is associated with improvement of factors other than weight loss. Objective: The purpose of this study was to determine whether improvement of BID during CBT for obesity was associated with improvement of factors other than weight loss. Methods: One hundred and sixty-five women (BMI 31.8 ± 5.2 kg/m2, age 49.3 ± 10.5 years) with overweight or obesity completed a 7-month CBT-based weight loss intervention. BID, depression, anxiety, binge eating, and perfectionism were assessed at both baseline and the end of the intervention through the use of psychological questionnaires. Results: Percent total weight loss, baseline BID, baseline binge eating disorder (BED), change in depression (Δdepression), Δstate anxiety, Δtrait anxiety, Δbinge eating, and Δperfectionism were significantly correlated with ΔBID. Multiple regression analysis showed that baseline BID, baseline BED, percent total weight loss, Δbinge eating, and Δdepression were independently associated with ΔBID. Conclusion: Improvement of binge eating, and improvement of depression, as well as weight loss, were independently associated with amelioration of BID. Clinical trial registration: [https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000008052], identifier [UMIN000006803] and [https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R0000 55850], identifier [UMIN000049041].

    DOI: 10.3389/fpsyt.2022.1025946

    Web of Science

    Scopus

    PubMed

  • Factors associated with the improvement of body image dissatisfaction of female patients with overweight and obesity during cognitive behavioral therapy. Reviewed International journal

    Yokoyama H, Nozaki T, Nishihara T, Sawamoto R, Komaki G, Sudo N.

    Front Psychiatry.   2022.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fpsyt.2022.1025946.

  • 公認心理師による拡大版認知行動療法(CBT-E)が強迫性に著効した神経性過食症の1症例

    永江 悠子, 高倉 修, 富岡 光直, 須藤 信行

    日本心療内科学会誌   26 ( 3 )   147 - 151   2022.10   ISSN:1342-9558

     More details

    Language:Japanese   Publisher:(NPO)日本心療内科学会  

    摂食障害は強迫性との関連が指摘されている。神経性過食症患者に対して,公認心理師が摂食障害に特化した治療法である拡大版認知行動療法(Enhanced Cognitive Behavior Therapy:CBT-E)を実施し,症状改善とともに強迫性にも改善が見られた1症例を報告する。症例は20代女性。CBT-Eのプロトコルに基づき,セルフモニタリングや規則正しい食事の確立等により過食症状は改善した。また,中核の精神病理を扱う中で,自身の完全主義的な傾向に気づき,「肩の力を抜くように」と生活にも変化が生じた。摂食障害評価質問票(EDE-Q),臨床的障害評価法(CIA)による自己評価でも,治療前後でスコアが改善した。CBT-Eは摂食障害の過食嘔吐の症状改善に有効であるだけでなく,治療による行動変容を通して,強迫性に苦慮していた患者が自身の生活や生き方を見直す契機にもなり得る。CBT-Eの実施にあたっては,公認心理師がCBT-Eを行い,それに併せて主治医が通常診療を行うという構造が現実的であり,また治療を促進するメリットもあると考えられる。(著者抄録)

  • Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology

    Hemmi T., Ainai A., Hashiguchi T., Tobiume M., Kanno T., Iwata-Yoshikawa N., Iida S., Sato Y., Miyamoto S., Ueno A., Sano K., Saito S., Shiwa-Sudo N., Nagata N., Tamura K., Suzuki R., Hasegawa H., Suzuki T.

    Vaccine   40 ( 41 )   5892 - 5903   2022.9   ISSN:0264410X

     More details

    Publisher:Vaccine  

    To control the coronavirus disease 2019 (COVID-19) pandemic, there is a need to develop vaccines to prevent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. One candidate is a nasal vaccine capable of inducing secretory IgA antibodies in the mucosa of the upper respiratory tract, the initial site of infection. However, regarding the development of COVID-19 vaccines, there is concern about the potential risk of inducing lung eosinophilic immunopathology as a vaccine-associated enhanced respiratory disease as a result of the T helper 2 (Th2)-dominant adaptive immune response. In this study, we investigated the protective effect against virus infection induced by intranasal vaccination of recombinant trimeric spike protein derived from SARS-CoV-2 adjuvanted with CpG oligonucleotides, ODN2006, in mouse model. The intranasal vaccine combined with ODN2006 successfully induced not only systemic spike-specific IgG antibodies, but also secretory IgA antibodies in the nasal mucosa. Secretory IgA antibodies showed high protective ability against SARS-CoV-2 variants (Alpha, Beta and Gamma variants) compared to IgG antibodies in the serum. The nasal vaccine of this formulation induced a high number of IFN-γ-secreting cells in the draining cervical lymph nodes and a lower spike-specific IgG1/IgG2a ratio compared to that of subcutaneous vaccination with alum as a typical Th2 adjuvant. These features are consistent with the induction of the Th1 adaptive immune response. In addition, mice intranasally vaccinated with ODN2006 showed less lung eosinophilic immunopathology after viral challenge than mice subcutaneously vaccinated with alum adjuvant. Our findings indicate that intranasal vaccine adjuvanted with ODN2006 could be a candidate that can prevent the infection of antigenically different variant viruses, reducing the risk of vaccine-associated enhanced respiratory disease.

    DOI: 10.1016/j.vaccine.2022.08.049

    Scopus

  • 医療刑務所における神経性やせ症女性患者に関する研究(第一報) 特徴的な諸群への分類

    瀧井 正人, 岸本 淳司, 遠山 岳詩, 海原 美香, 須藤 信行, 迎 伸彦

    精神神経学雑誌   124 ( 9 )   601 - 622   2022.9   ISSN:0033-2658

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    わが国の矯正施設では近年摂食障害(ED)の受刑者が増加し,女子刑務所などの現場では対応に大変苦慮している.重篤で一般刑務所では対応困難な症例は,医療刑務所に移送される.北九州医療刑務所(以下,当所)では,患者の受け入れを2012年5月より開始し集約的な治療を行ってきた.【目的】当所に入所した100人の神経性やせ症(AN)女性患者を分類し比較することにより,その病態理解を進める.【方法】矯正施設初回入所以前の,EDの病歴と覚醒剤乱用歴の有無により,「ED病歴(+)覚醒剤歴(-)」群,「ED病歴(-)覚醒剤歴(-)」群,「覚醒剤歴(+)ED病歴(+)」群,「覚醒剤歴(+)ED病歴(-)」群に分類し,人口統計学的,臨床的,心理社会的データの比較を行った.【結果】大多数を占めたのは「ED病歴(+)覚醒剤歴(-)」群(n=74)であり,若くして典型的なEDを発症しきわめて長い病歴をもった,重症遷延性神経性やせ症(SEAN)であった.「ED病歴(-)覚醒剤歴(-)」群(n=13)は,中高年になり逮捕や収容を契機にEDを出現させていた.「覚醒剤歴(+)ED病歴(-)」群(n=9)は,矯正施設収容以後に,ほぼ矯正施設内限定でEDの症状を出現させていた.「ED病歴(-)覚醒剤歴(-)」群と「覚醒剤歴(+)ED病歴(-)」群は非典型的なEDの病像を示し,やせ願望は比較的軽度であった.重篤で長いED病歴をもつ「ED病歴(+)覚醒剤歴(-)」群においても,矯正施設初回入所以前にED治療を受けた者は,約半数にすぎなかった.【考察】ANの女性受刑者は均一の集団ではなく,治療や対応はそれぞれの病態に適合させる必要があるため,これらの分類は治療のために有益である.「ED病歴(+)覚醒剤歴(-)」群は,数の多さからもEDの典型性や重篤性からも臨床的に特に重要である.医療刑務所のAN患者の病態や治療について,今後も系統的多面的に研究を進め,報告する予定である.(著者抄録)

  • Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study. Reviewed International journal

    Hirabayashi N, Hata J, Furuta Y, Ohara T, Shibata M, Hirakawa Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Ninomiya T.

    Diabetes Care   45 ( 6 )   1364 - 1371   2022.6

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc21-1911.

  • 慢性疲労症候群患者のエゴグラムと精神症状との関連

    野口 敬蔵, 吉原 一文, 富岡 光直, 須藤 信行

    交流分析研究   47 ( 1 )   17 - 19   2022.6   ISSN:0285-7774

     More details

    Language:Japanese   Publisher:日本交流分析学会  

    慢性疲労症候群(CFS)患者のエゴグラムと精神症状の関連について明らかにすることを目的に、A病院心療内科に入院したCFS患者34名(男性8名、女性26名、平均年齢34.6±14.7歳)を対象に、東大式エゴグラムバージョンII(TEGII)、抑うつ状態自己評価尺度(CES-D)、症状チェックリスト(SCL-90-R)を実施した。TEGIIのFC(自由な子どもの自我状態)の得点と抑うつ、強迫症状、対人過敏の得点との関連を検討した結果、FCと強迫症状、FCと対人過敏のそれぞれの間で、有意な負の相関がみられたほか、FCと抑うつの間にも負の相関が認められ、有意ではないものの、有意傾向にあった。また、TEGIIのAC(適応的な子どもの自我状態)の得点と抑うつ、強迫症状、対人過敏の得点との関連を検討した結果、ACと抑うつ、ACと強迫症状、ACと対人過敏のそれぞれの間で、有意な正の相関がみられた。

  • Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study

    Hirabayashi, N; Hata, J; Furuta, Y; Ohara, T; Shibata, M; Hirakawa, Y; Yamashita, F; Yoshihara, K; Kitazono, T; Sudo, N; Ninomiya, T

    DIABETES CARE   45 ( 6 )   1364 - 1371   2022.6   ISSN:0149-5992 eISSN:1935-5548

     More details

    Language:English   Publisher:Diabetes Care  

    OBJECTIVE To examine the association between diabetes and gray matter atrophy patterns in a general older Japanese population. RESEARCH DESIGN AND METHODS In 2012, a total of 1,189 community-dwelling Japanese aged ≥65 years underwent brain MRI scans. Regional gray matter volumes (GMV) and intracranial volume (ICV) were measured by applying voxel-based morphometry (VBM) methods. The associations of diabetes and related parameters with the regional GMV/ICV were examined using an ANCOVA. The regional gray matter atrophy patterns in the subjects with diabetes or elevated fasting plasma glucose (FPG) or 2-h postload glucose (2hPG) levels were investigated using VBM. RESULTS Subjects with diabetes had significantly lower mean values of GMV/ICV in the frontal lobe, temporal lobe, insula, deep gray matter structures, and cerebellum than subjects without diabetes after adjusting for potential confounders. A longer duration of diabetes was also significantly associated with lower mean values of GMV/ICV in these brain regions. The multivariable-adjusted mean values of the temporal, insular, and deep GMV/ICV decreased significantly with elevating 2hPG levels, whereas higher FPG levels were not significantly associated with GMV/ICV of any brain regions. In the VBM analysis, diabetes was associated with gray matter atrophy in the bilateral superior temporal gyri, right middle temporal gyrus, left inferior temporal gyrus, right middle frontal gyrus, bilateral thalami, right caudate, and right cerebellum. CONCLUSIONS The current study suggests that a longer duration of diabetes and elevated 2hPG levels are significant risk factors for gray matter atrophy in various brain regions.

    DOI: 10.2337/dc21-1911

    Web of Science

    Scopus

    PubMed

  • Association between chronic low back pain and regional brain atrophy in a Japanese older population: the Hisayama Study. Reviewed International journal

    Asada M, Shibata M, Hirabayashi N, Ohara T, Furuta Y, Nakazawa T, Honda T, Hata J, Hosoi M, Sudo N, Yamaura K, Ninomiya T.

    Pain   2022.3

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/j.pain.0000000000002612.

  • Psychological Traits of Patients With Depression Comorbid With Chronic Pain: Are Complaint and Competitive Tendency Related to Pain?

    Fujimoto, K; Hosoi, M; Katsuki, R; Matsushima, T; Matsuo, K; Nakao, T; Sudo, N; Kato, TA

    FRONTIERS IN PSYCHIATRY   13   825422   2022.2   ISSN:1664-0640

     More details

    Language:English   Publisher:Frontiers in Psychiatry  

    Background: Modern-Type Depression (MTD) is a category of depression that has been studied mainly in Japan; however, no study has attempted to determine its relation to chronic pain. Aim: To determine possible associations between psychological traits related to MTD and the chronic pain of patients at psychiatric clinics. Method: Two hundred and twenty-one first time patients who visited the psychiatric clinic at a Japanese university medical center or an associated clinic were enrolled. The Hamilton Depression Rating Scale was used to measure depressive symptoms. The 22-item Tarumi's Modern-Type Depression Trait Scale (TACS-22), Achievement Motive, and 20-item Toronto Alexithymia Scale were used to assess psychological traits related to depression and chronic pain. The clinical diagnosis of each patient was confirmed by use of the Structured Clinical Interview for DSM-IV Axis I Disorders, administered by experienced specialists. The medians of the psychological traits identified were compared between patients with or without chronic pain. Analysis was also done of patients with Major Depressive Disorder (MDD). Result: Of the 221 patients, 139 had chronic pain. Patients with chronic pain had more severe depressive symptoms, Alexithymia, and high scores for the complaint trait of MTD. Seventy-three of the 221 patients met the criteria for MDD (53 had chronic pain). Patients with MDD comorbid with chronic pain had a higher competitive achievement score, severe depression, and difficulty identifying feelings. Conclusion: Complaint and competitive traits were shown to be related to chronic pain in psychiatric settings. Further study will allow us to design multidimensional approach for patients suffering from depression.

    DOI: 10.3389/fpsyt.2022.825422

    Web of Science

    Scopus

    PubMed

  • Dietary tryptophan, tyrosine, and phenylalanine depletion induce reduced food intake and behavioral alterations in mice. International journal

    Xueting Zhang, Kazufumi Yoshihara, Noriyuki Miyata, Tomokazu Hata, Altanzul Altaisaikhan, Shu Takakura, Yasunari Asano, Satoshi Izuno, Nobuyuki Sudo

    Physiology & behavior   244   113653 - 113653   2022.2   ISSN:0031-9384 eISSN:1873-507X

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Important precursors of monoaminergic neurotransmitters, dietary tryptophan (TRP), tyrosine, and phenylalanine (all referred to as TTP), play crucial roles in a wide range of behavioral and emotional functions. In the current study, we investigated whether diets devoid of TTP or diets deficient in TRP alone can affect body weight, behavioral characteristics, and gut microbiota, by comparing mice fed on these amino acids-depleted diets to mice fed on diets containing regular levels of amino acids. Both dietary TTP- and TRP-deprived animals showed a reduction in food intake and body weight. In behavioral analyses, the mice fed TTP-deprived diets were more active than mice fed diets containing regular levels of amino acids. The TRP-deprived group exhibited a reduction in serum TRP levels, concomitant with a decrease in serotonin and 5-hydroxyindoleacetic acid levels in some regions of the brain. The TTP-deprived group showed a reduction in TTP levels in the serum, concomitant with decreases in both phenylalanine and tyrosine levels in the hippocampus, as well as serotonin, norepinephrine, and dopamine concentrations in some regions of the brain. Regarding the effects of TRP or TTP deprivation on gut microbial ecology, the relative abundance of genus Roseburia was significantly reduced in the TTP-deprived group than in the dietary restriction control group. Interestingly, TTP was found even in the feces of mice fed TTP- and TRP-deficient diets, suggesting that TTP is produced by microbial or enzymatic digestion of the host-derived proteins. However, microbe generated TTP did not compensate for the systemic TTP deficiency induced by the lack of dietary TTP intake. Collectively, these results indicate that chronic dietary TTP deprivation induces decreased monoamines and their metabolites in a brain region-specific manner. The altered activities of the monoaminergic systems may contribute to increased locomotor activity.

    DOI: 10.1016/j.physbeh.2021.113653

    Web of Science

    Scopus

    PubMed

    researchmap

  • Psychological Traits of Patients With Depression Comorbid With Chronic Pain: Are Complaint and Competitive Tendency Related to Pain? Reviewed International journal

    Fujimoto K, Hosoi M, Katsuki R, Matsushima T, Matsuo K, Nakao T, Sudo N, Kato TA.

    Front Psychiatry   2022.2

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fpsyt.2022.825422.

  • Dietary tryptophan, tyrosine, and phenylalanine depletion induce reduced food intake and behavioral alterations in mice. Reviewed International journal

    Zhang X, Yoshihara K, Miyata N, Hata T, Altaisaikhan A, Takakura S, Asano Y, Izuno S, Sudo N.

    Physiol Behav   2022.2

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.physbeh.2021.113653.

  • The effectiveness of Pictorial Representation of Illness and Self Measure (PRISM) for the assessment of the suffering and quality of interpersonal relationships of patients with chronic pain (vol 15, 22, 2021)

    Tomioka, M; Hosoi, M; Okuzawa, T; Anno, K; Iwaki, R; Kawata, H; Kubo, C; Sudo, N

    BIOPSYCHOSOCIAL MEDICINE   16 ( 1 )   4   2022.1   ISSN:1751-0759

     More details

    Language:English   Publisher:BioPsychoSocial Medicine  

    Following publication of the original article [1], the authors identified an error in Fig. 3 and Table 6. In the old Fig. 3, there was a layout problem in the upper right part of the figure. The word “tests” in the sentence “7 were fit. But it had completed outpatient PRISM and pain-related tests” was out of the box. In the old Table 6, eight respondents were shown for the two questions, each person’s comment consisted of two comment parts before (T0) and after (T1). The old table cannot distinguish between them. The author put the replaced shapes in the table in the extended metafile so that it wouldn’t get out of shape. The correct figure and table have been included in this correction, and the original article has been corrected.

    DOI: 10.1186/s13030-021-00230-1

    Web of Science

    Scopus

    PubMed

  • Potential impact of the COVID-19 pandemic on japanese patients with eating disorders -a cross-sectional study

    Takakura, S; Toda, K; Yamashita, M; Kitajima, T; Suematsu, T; Yokoyama, H; Asou, CS; Hata, T; Sudo, N

    BIOPSYCHOSOCIAL MEDICINE   16 ( 1 )   2   2022.1   ISSN:1751-0759

     More details

    Language:English   Publisher:BioPsychoSocial Medicine  

    Background: The COVID-19 pandemic and associated lockdown had a considerable impact on eating disorders (EDs). We evaluated the clinical features of Japanese ED patients before and after the first COVID-19 outbreak-related state of emergency (April 7, 2020). Methods: We studied 148 patients who were divided into two groups based on when they arrived at our clinic: before (Before group: n = 86) or after (After group: n = 62) the start of the first state of emergency. All patients completed the Japanese versions of the Eating Disorder Inventory (EDI) and Parental Bonding Instrument (PBI). Results: The After group was substantially younger than the Before group (p =.0187). Regardless of the ED type, patients who developed an ED during the first state of emergency tended to be significantly younger than those who developed one before. Differences in EDI characteristics were observed between the two groups. The PBI care subscale was notably higher (p =.0177) in the After group. The PBI maternal care subscale was the only statistically significant factor associated with age (β = -0.35, p <.0001). Conclusions: Home confinement associated with the COVID-19 pandemic and the ensuing increase in parent-child closeness may have influenced the decreased age of ED patients at their initial consultation. Treatment interventions should consider the differences in the clinical features of EDs.

    DOI: 10.1186/s13030-021-00232-z

    Web of Science

    Scopus

    PubMed

  • Potential impact of the COVID-19 pandemic on japanese patients with eating disorders -a cross-sectional study. Reviewed International journal

    Takakura S, Toda K, Yamashita M, Kitajima T, Suematsu T, Yokoyama H, Asou CS, Hata T, Sudo N.

    Biopsychosoc Med   2022.1

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13030-021-00232-z.

  • 摂食障害の日本人患者におけるCOVID-19パンデミックの潜在的影響 横断的研究(Potential impact of the COVID-19 pandemic on japanese patients with eating disorders -a cross-sectional study)

    Takakura Shu, Toda Kenta, Yamashita Makoto, Kitajima Tomoko, Suematsu Takafumi, Yokoyama Hiroaki, Suzuyama Asou Chie, Hata Tomokazu, Sudo Nobuyuki

    Biopsychosocial Medicine   16   1 of 6 - 6 of 6   2022.1

     More details

    Language:English   Publisher:(一社)日本心身医学会  

    COVID-19パンデミックといろいろな制限による摂食障害(ED)患者への影響を調べるため、第1回緊急事態宣言発出(2020年4月7日)前後のED患者の臨床的特徴を比較した。宣言前に九州大学心療内科に来院した患者86名(前群)とその後に来院した患者62名(後群)を比較した。Eating Disorder Inventory(EDI)とParental Bonding Instrument(PBI)を用いた自己記入調査を行った。後群は前群よりもかなり若かった。EDの型に関係なく、宣言発出前にED発症した患者よりも宣言中に発症した患者のほうが有意に若い傾向があった。両群でEDIの特徴に相異が観察された。PBI養育サブスケールが後群でかなり高かった。PBI母性保護サブスケールのみが、年齢と関連する因子であった。

  • The effectiveness of Pictorial Representation of Illness and Self Measure (PRISM) for the assessment of the suffering and quality of interpersonal relationships of patients with chronic pain. Reviewed International journal

    Tomioka M, Hosoi M, Okuzawa T, Anno K, Iwaki R, Kawata H, Kubo C, Sudo N.

    Biopsychosoc Med   2021.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1186/s13030-021-00223-0.

  • Association of lifestyle factors with osteoporosis and fracture in postmenopausal women: a Japanese cohort study. Reviewed International journal

    Otonari J, Ikezaki H, Furusyo N, Sudo N.

    Menopause   28 ( 11 )   1254 - 1263   2021.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/GME.0000000000001840.

  • Do neuroticism and extraversion personality traits influence disease-specific risk factors for mortality from cancer and cardiovascular disease in a Japanese population? Reviewed

    Otonari J, Ikezaki H, Furusyo N, Sudo N.

    Journal of Psychosomatic Research   144   110422   2021.5

     More details

    Language:English  

    DOI: 10.1016/j.jpsychores.2021.110422

  • Metabolomics profile of Japanese female patients with restricting-type anorexia nervosa. Reviewed

    Miyata N, Hata T,Takakura S, Yoshihara K, Morita C, Mikami K, Nomoto K, Miyazak Ki, Tsuji H, Sudo N.

    Physiology and Behavior   228   113204   2021.1

     More details

    Language:English  

    DOI: 10.1016/j.physbeh.2020.113204.

  • Dietary delivery of acetate to the colon using acylated starches as a carrier exerts anxiolytic effects in mice Reviewed International journal

    Kimura-Todani T, Hata T, Miyata N, Takakura S, Yoshihara K, Xue Ting Zhang, Asano Y, Altanzul Altaisaikhan, Tsukahara T, Sudo N.

    Physiology and Behavior   223   113004 - 113004   2020.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.physbeh.2020.113004

  • Correction to Very long chain fatty acids are an important marker of nutritional status in patients with anorexia nervosa: a case control study Reviewed

    Shimizu M, Kawai K, Yamashita M, Shoji M, Takakura S, Hata T, Nakashima M,Tatsushima K, Tanaka K, Sudo N.

    BioPsychoSocial Medicine   14   18   2020.8

     More details

    Language:English  

    DOI: 10.1186/s13030-020-00192-w

  • Development of a new Japanese version of the Clinical Impairment Assessment Questionnaire Reviewed International journal

    Horie T, Hiraide M, Takakura S, Hata T, Sudo N, Yoshiuchi k.

    BioPsychoSocial Medicine   14   19 - 19   2020.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13030-020-00194-8

  • Parenting style during childhood is associated with the development of chronic pain and a patient's need for psychosomatic treatment in adulthood A case-control study Reviewed International journal

    Shibata M, Ninomiya T, Anno K,Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M.

    Medicine   99 ( 29 )   e21230   2020.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MD.0000000000021230

  • Very long chain fatty acids are an important marker of nutritional status in patients with anorexia nervosa a case control study Reviewed

    Shimizu M, Kawai K, Yamashita M, Shoji M, Takakura S, Hata T, Nakashima M, Tatsushima K, Tanaka K,Sudo N.

    BioPsychoSocial Medicine   14 ( 1 )   2020.7

     More details

    Language:English  

    DOI: 10.1186/s13030-020-00186-8

  • Effectiveness of enhanced cognitive behavior therapy for bulimia nervosa in Japan A randomized controlled trial protocol Reviewed International journal

    Ohara C, Sekiguch Ai, Takakura S, Endo Y, Tamura N, Kikuchi H, Maruo K, Sugawara N, Hatano K, Kawanishi H, Funaba M, Sugawara A, Nohara N, Kawa Ki, Fukudo S, Sudo N, Zafra Cooper, Yoshiuchi K, Ando T.

    BioPsychoSocial Medicine   14 ( 1 )   2 - 2   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13030-020-0174-z

  • Physical and psychological aspects of anorexia nervosa based on duration of illness A cross-sectional study Reviewed

    Takakura S, Suzuyama Aso C, Toda K, Hata T, Yamashita M,Sudo N.

    BioPsychoSocial Medicine   13 ( 1 )   2019.12

     More details

    Language:English  

    DOI: 10.1186/s13030-019-0173-0

  • Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome An explorative pilot study Reviewed

    BioPsychoSocial Medicine   13 ( 1 )   2019.12

     More details

    Language:English  

    DOI: 10.1186/s13030-019-0171-2

  • Physical and psychological aspects of anorexia nervosa based on duration of illness: a cross-sectional study. Invited Reviewed International journal

    Takakura S, Suzuyama Aso C, Sudo N, et al.

    BIOPSYCHOSOCIAL MEDICINE   13   32   2019.12

     More details

    Language:English  

  • Effects of Weight Loss on Sweet Taste Preference and Palatability following Cognitive Behavioral Therapy for Women with Obesity Reviewed

    Nishihara T, Nozaki T, Sawamoto R, Komaki G, Miyata N, Hosoi M, Sudo N.

    Obesity Facts   12 ( 5 )   529 - 542   2019.10

     More details

    Language:English  

    DOI: 10.1159/000502236

  • Biogenic Amines Signals Between Commensal Microbiota and Gut Physiology Reviewed

    Sudo N.

    Frontiers in Endocrinology   10   504   2019.7

     More details

    Language:English  

    DOI: 10.3389/fendo.2019.00504

  • Predictors of objectively measured snoring in a working population Reviewed

    Furukawa T, Nakano H, Yoshihara K, Sudo N.

    Sleep and Biological Rhythms   17 ( 3 )   349 - 354   2019.4

     More details

    Language:English  

  • Role of gut microbiota in brain function and stress-related pathology Reviewed

    Sudo N.

    Bioscience of Microbiota, Food and Health   38 ( 3 )   75 - 80   2019.3

     More details

    Language:English  

    DOI: 10.12938/bmfh.19-006

  • Protective Role of the Hepatic Vagus Nerve against Liver Metastasis in Mice Reviewed International journal

    Hiramoto T, Yoshihara K, Asano Y, Sudo N.

    NeuroImmunoModulation   24 ( 6 )   341 - 347   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000487483

  • Changes in fatigue, autonomic functions, and blood biomarkers due to sitting isometric yoga in patients with chronic fatigue syndrome Reviewed

    Oka T, Tanahashi T, Sudo N, Battuvshin Lkhagvasuren,Yamada Y.

    BioPsychoSocial Medicine   12 ( 1 )   2018.4

     More details

    Language:English  

    DOI: 10.1186/s13030-018-0123-2

  • Fibromyalgia and microglial TNF-α Translational research using human blood induced microglia-like cells Reviewed

    7 ( 1 )   2017.12

     More details

    Language:English  

    DOI: 10.1038/s41598-017-11506-4

  • Regulation of gut luminal serotonin by commensal microbiota in mice Reviewed International journal

    Hata T, Asano Y, Yoshihara K, Kimura-Todani T, Miyata N, Xue Ting Zhang, Takakura S, Aiba Y, Koga Y, Sudo N.

    PloS one   12 ( 7 )   e0180745   2017.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0180745

  • Predictors of successful long-term weight loss maintenance A two-year follow-up Reviewed

    Sawamoto R, Nozaki T, Nishihara T,Furukawa T, Hata , Komaki G, Sudo N.

    BioPsychoSocial Medicine   11 ( 1 )   2017.6

     More details

    Language:English  

    DOI: 10.1186/s13030-017-0099-3

  • Cross-talk between immune system and brain Reviewed

    Sudo N.

    Japanese Journal of Allergology   6 ( 3 )   147 - 152   2017.5

     More details

    Language:English  

  • Ghrelin activation and neuropeptide Y elevation in response to medium chain triglyceride administration in anorexia nervosa patients Reviewed

    Kawai K, Nakashima M, Kojima M, Yamashita S, Takakura S, Shimizu M, Kubo C, Sudo N.

    Clinical Nutrition ESPEN   17   100 - 104   2017.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.clnesp.2016.10.001

  • Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants Reviewed International journal

    Koga Y, Tokunaga S, Nagano J, Sato F, Konishi K, Tochio T, Murakam Yi, Masumoto N, Tezuka J, Sudo N, Kubo C, Shibata R.

    Pediatric Research   80 ( 6 )   844 - 851   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/pr.2016.167

  • The relationship between snoring sound intensity and morning blood pressure in workers Reviewed International journal

    Furukawa T, Nakano H, Yoshihara K, Sudo N.

    Journal of Clinical Sleep Medicine   12 ( 12 )   1601 - 1606   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5664/jcsm.6340

  • Family dysfunction A comparison of chronic widespread pain and chronic localized pain Reviewed

    Hayaki C, Anno K, Shibata M, Iwaki R, Kawata H, Sudo N, Hosoi M.

    Medicine (United States)   95 ( 49 )   e5495   2016.12

     More details

    Language:English  

    DOI: 10.1097/MD.0000000000005495

  • Association between diabetes and hippocampal atrophy in Elderly Japanese The Hisayama study Reviewed International journal

    Hirabayashi N,Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T.

    Diabetes care   39 ( 9 )   1543 - 1549   2016.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc15-2800

  • Inhibition of emotional needs and emotional wellbeing predict disease progression of chronic hepatitis C patients An 8-year prospective study Reviewed International journal

    Sawamoto R, Nagano J, Kajiwara E, Sonoda J, Hiramoto T,Sudo N.

    BioPsychoSocial Medicine   10 ( 1 )   24 - 24   2016.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13030-016-0075-3

  • Perceived inadequate care and excessive overprotection during childhood are associated with greater risk of sleep disturbance in adulthood The Hisayama Study Reviewed

    Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M.

    BMC Psychiatry   16 ( 1 )   2016.7

     More details

    Language:English  

    DOI: 10.1186/s12888-016-0926-2

  • Neural correlates of fear-induced sympathetic response associated with the peripheral temperature change rate Reviewed International journal

    Yoshihara K, C. Tanabe H, Kawamichi H, Koike T, Yamazaki M, Sudo N, Sadato N.

    NeuroImage   134   522 - 531   2016.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuroimage.2016.04.040

  • A change in objective sleep duration is associated with a change in the serum adiponectin level of women with overweight or obesity undergoing weight loss intervention Reviewed

    Sawamoto R, Nozaki T,Furukawa T, Tanahashi T, Morita C, Hata T, Nakashima M, Komaki G, Sudo N.

    Obesity Science and Practice   2 ( 2 )   180 - 188   2016.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/osp4.32

  • The Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota A Target for Dietary Intervention?

    Sudo N.

    The Gut-Brain Axis Dietary, Probiotic, and Prebiotic Interventions on the Microbiota   293 - 304   2016.6

     More details

    Language:English  

    DOI: 10.1016/B978-0-12-802304-4.00013-X

  • Effects of gut microbiota on stress response and behavioral phenotype of the host Reviewed

    Sudo N.

    Brain and Nerve   68 ( 6 )   595 - 605   2016.6

     More details

    Language:English  

  • Predictors of dropout by female obese patients treated with a group cognitive behavioral therapy to promote weight loss Reviewed

    Sawamoto R, Nozaki T, Furukawa T, Tanahashi T, Morita C, Hata T, Komaki G, Sudo N.

    Obesity Facts   9 ( 1 )   29 - 38   2016.3

     More details

    Language:English  

    DOI: 10.1159/000442761

  • Three cases of appendicitis with anorexia nervosa under inpatient care Reviewed

    Takakura S, Yokoyama H, Suzuyama C,Tatsushima K, Yamashita M, Gondou M, Morita C, Hata T, Takii M, Kawai K, Sudo N.

    Journal of Eating Disorders   3 ( 1 )   2015.11

     More details

    Language:English  

    DOI: 10.1186/s40337-015-0076-9

  • Prior chronic stress induces persistent polyI C-induced allodynia and depressive-like behavior in rats: Possible involvement of glucocorticoids and microglia Reviewed International journal

    Chijiwa T,Oka T, Battuvshin Lkhagvasuren, Yoshihara K, Sudo N.

    Physiology and Behavior   147   264 - 273   2015.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.physbeh.2015.04.050

  • Paternal and maternal bonding styles in childhood are associated with the prevalence of chronic pain in a general adult population The Hisayama Study Reviewed

    Anno K, Shibata M, Ninomiya T, Iwaki R, Kawata H, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M.

    BMC Psychiatry   15 ( 1 )   2015.7

     More details

    Language:English  

    DOI: 10.1186/s12888-015-0574-y

  • Life events, emotional responsiveness, and the functional prognosis of patients with rheumatoid arthritis Reviewed International journal

    Nagano J, Sudo N, Nagaoka S, Yukioka M, Kondo M.

    BioPsychoSocial Medicine   9 ( 1 )   15 - 15   2015.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13030-015-0043-3

  • Brain-gut axis and gut microbiota Possible role of gut microbiota in childhood mental health and diseases Reviewed

    Sudo N.

    Journal of Pediatric Biochemistry   5 ( 2 )   77 - 80   2015.6

     More details

    Language:English  

    DOI: 10.1055/s-0035-1564579

  • Isometric yoga improves the fatigue and pain of patients with chronic fatigue syndrome who are resistant to conventional therapy A randomized, controlled trial Reviewed

    Oka T, Tanahashi T, Chijiwa T, Battuvshin Lkhagvasuren, Sudo N, Oka K.

    BioPsychoSocial Medicine   8 ( 1 )   2014.12

     More details

    Language:English  

    DOI: 10.1186/s13030-014-0027-8

  • Higher sleep fragmentation predicts a lower magnitude of weight loss in overweight and obese women participating in a weight-loss intervention Reviewed

    Sawamoto R, Nozaki T, Furukawa T, Tanahashi T, Morita C , Hata T, Komaki G, Sudo N.

    Nutrition and Diabetes   4   e144   2014.10

     More details

    Language:English  

    DOI: 10.1038/nutd.2014.41

  • Characteristics of the orthostatic cardiovascular response in adolescent patients with psychogenic fever Reviewed

    Battuvshin Lkhagvasuren, Tanaka H, Sudo N, Kubo C, Oka T.

    Psychotherapy and Psychosomatics   83 ( 5 )   318 - 319   2014.8

     More details

    Language:English  

    DOI: 10.1159/000360999

  • [Cognitive behavioral treatment of obesity--psychosomatic approach of lifestyle modification] Reviewed

    Nozaki T, Sawamoto R, Sudo N.

    Fukuoka igaku zasshi = Hukuoka acta medica   105 ( 7 )   139 - 147   2014.7

     More details

    Language:English  

  • Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment Reviewed

    B. Lkhagvasuren,Oka T, Nakamura Y, Hayashi H, Sudo N,Nakamura K.

    Neuroscience   272   34 - 57   2014.7

     More details

    Language:English  

    DOI: 10.1016/j.neuroscience.2014.04.047

  • Microbiome, HPA axis and production of endocrine hormones in the gut Reviewed

    Sudo N.

    Advances in experimental medicine and biology   817   177 - 194   2014.6

     More details

    Language:English  

    DOI: 10.1007/978-1-4939-0897-4_8

  • Alexithymia is associated with greater risk of chronic pain and negative affect and with lower life satisfaction in a general population The Hisayama study Reviewed International journal

    Shibata M, Ninomiya T, Mark P. Jensen, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T,Imada Y, Kubo C, Kiyohara Y, Sudo N, Hosoi M.

    PloS one   9 ( 3 )   e90984   2014.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0090984

  • The outcome of treatment for anorexia nervosa inpatients who required urgent hospitalization Reviewed

    Kawai K, Yamashita M, Komaki G, Shimizu M, Nakashima M, Etou S, Takakura S, Takii M, Kubo C, Sudo N.

    BioPsychoSocial Medicine   8 ( 1 )   2014.3

     More details

    Language:English  

    DOI: 10.1186/1751-0759-8-20

  • Effect of 12 weeks of yoga training on the somatization, psychological symptoms, and stress-related biomarkers of healthy women Reviewed International journal

    Yoshihara K, Hiramoto T,Oka T, Kubo C, Sudo N.

    BioPsychoSocial Medicine   8 ( 1 )   1 - 1   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1751-0759-8-1

  • Higher sleep fragmentation predicts a lower magnitude of weight loss in overweight and obese women participating in a weight-loss intervention Reviewed

    Sawamoto R, Nozaki T, Furukawa T,Tanahashi T, Morita C,Hata T,Komaki G, Sudo N.

    Nutrition and Diabetes   4 ( 10 )   2014.1

     More details

    Language:English  

    DOI: 10.1038/nutd.2014.41

  • Regulation of host stress response by gut microbiota Reviewed

    Sudo N.

    Skin Research   12 ( SUPPL. 20 )   37 - 41   2013.10

     More details

    Language:English  

  • The reliability and validity of a newly developed scale for measuring a negative cognition towards diabetes Reviewed

    Takii M, Uchigata Y, Kishimoto J, Okada A, Matsumoto M,Morita C, Hata T, Nozak Ti,Kawai K,Sudo N.

    Journal of the Japan Diabetes Society   56 ( 8 )   560 - 569   2013.8

     More details

    Language:English  

  • Increased prevalence of postural orthostatic tachycardia syndrome in psychogenic fever patients Reviewed

    Battuvshin Lkhagvasuren,Masuno T, Kanemitsu Y, Sudo N, Kubo C, Oka T.

    Psychotherapy and Psychosomatics   82 ( 4 )   269 - 270   2013.6

     More details

    Language:English  

    DOI: 10.1159/000345171

  • Alexithymia and chronic pain The role of negative affectivity Reviewed

    Makino S, Mark P. Jensen, Arimura T, Obata T, Anno K,Iwaki R, Kubo C, Sudo N, Hosoi M.

    Clinical Journal of Pain   29 ( 4 )   354 - 361   2013.4

     More details

    Language:English  

    DOI: 10.1097/AJP.0b013e3182579c63

  • Chronic psychological stress exaggerates the compound 48/80-induced scratching behavior of mice Reviewed

    Peng Z, Hiramoto T, Asano Y, Kubo C, Sudo N.

    Pharmacology Biochemistry and Behavior   105   173 - 176   2013.4

     More details

    Language:English  

    DOI: 10.1016/j.pbb.2013.02.014

  • Psychological stress contributed to the development of low-grade fever in a patient with chronic fatigue syndrome A case report Reviewed

    Oka T, Kanemitsu Y, Sudo N, Hayashi H, Oka K.

    BioPsychoSocial Medicine   7 ( 1 )   2013.3

     More details

    Language:English  

    DOI: 10.1186/1751-0759-7-7

  • Role of microbiome in regulating the HPA axis and its relevance to allergy. Reviewed

    Sudo N.

    Chemical immunology and allergy   98   163 - 175   2012.12

     More details

    Language:English  

  • Daily physical complaints and hippocampal function An fMRI study of pain modulation by anxiety Reviewed

    Gondo M, Moriguchi Y, Kodama N, Sato N, Sudo N, Kubo C, Komaki G.

    NeuroImage   63 ( 3 )   1011 - 1019   2012.11

     More details

    Language:English  

    DOI: 10.1016/j.neuroimage.2012.07.025

  • Role of microbiome in regulating the HPA axis and its relevance to allergy. Reviewed International journal

    Sudo N.

    Chem Immunol Allerg   98   2012.6

     More details

    Language:English  

  • Global Catastrophizing vs Catastrophizing Subdomains Assessment and Associations with Patient Functioning Reviewed

    Iwaki R, Arimura T, Mark P. Jensen, Nakamura T, Yamashiro K, Makino S, Obata T, Sudo N, Kubo C, Hosoi M.

    Pain Medicine (United States)   13 ( 5 )   677 - 687   2012.5

     More details

    Language:English  

    DOI: 10.1111/j.1526-4637.2012.01353.x

  • Pain Questionnaire Development Focusing on Cross-Cultural Equivalence to the Original Questionnaire The Japanese Version of the Short-Form McGill Pain Questionnaire Reviewed

    Arimura T, Hosoi M, Tsukiyama Y, Yoshida T, Fujiwara D, Tanaka M, Tamura R, Nakashima Y, Sudo N, Kubo C.

    Pain Medicine   13 ( 4 )   541 - 551   2012.4

     More details

    Language:English  

    DOI: 10.1111/j.1526-4637.2012.01333.x

  • Factors that predict adherence to continuous positive airway pressure treatment in obstructive sleep apnea patients A prospective study in Japan Reviewed

    Tanahashi T, Nagano J, Yamaguchi Y, Kubo C, Sudo N.

    Sleep and Biological Rhythms   10 ( 2 )   126 - 135   2012.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1479-8425.2011.00533.x

  • The outcome of Japanese anorexia nervosa patients treated with an inpatient therapy in an internal medicine unit Reviewed

    Amemiya N, Taki Mi, Hata T, Morita C, Takakura S, Oshikiri K,Urabe H, Tokunaga S, Nozaki T, Kawai K, Sudo N, Kubo C.

    Eating and Weight Disorders   17 ( 1 )   e1 - e8   2012.3

     More details

    Language:English  

    DOI: 10.3275/8034

  • [Health consequences of snoring and obstructive sleep apnea]. Reviewed

    Furukawa T, Sudo N.

    Fukuoka igaku zasshi = Hukuoka acta medica   103 ( 1 )   1 - 11   2012.1

     More details

    Language:English  

  • The longitudinal BMI pattern and body composition of patients with anorexia nervosa who require urgent hospitalization A case control study Reviewed

    Kawai K,Yamashita S, Yamanaka T, Gondo M, Morita C, Nozaki T, Takakura S, Hata T, Yamada Y, Matsubayashi S, Takii M, Kubo C,Sudo N.

    BioPsychoSocial Medicine   ( 5 )   14(1) - 14(8)   2011.12

     More details

    Language:English  

  • Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region Reviewed

    Battuvshin L, Nakamura Y, Oka T, Sudo N, Nakamura K.

    European Journal of Neuroscience   34 ( 9 )   1442 - 1452   2011.11

     More details

    Language:English  

    DOI: 10.1111/j.1460-9568.2011.07863.x

  • Profile of mood states and stress-related biochemical indices in long-term yoga practitioners Reviewed International journal

    Yoshihara K, Hiramoto T, Sudo N, Kubo C.

    BioPsychoSocial Medicine   5 ( 1 )   6 - 6   2011.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1751-0759-5-6

  • The relationship between the age of onset of type 1 diabetes and the subsequent development of a severe eating disorder by female patients Reviewed

    Takii M, Uchigata Y, Kishimoto J, Morita C, Hata T, Nozaki T, Kawai K, Iwamoto Y, Sudo N,Kubo C.

    Pediatric Diabetes   12 ( 4 PART 2 )   396 - 401   2011.6

     More details

    Language:English  

    DOI: 10.1111/j.1399-5448.2010.00708.x

  • Predictors of menstrual resumption by patients with anorexia nervosa Reviewed

    Arimura C, Nozaki T, Takakura S,Kawai K, Takii M, Sudo N, Kubo C.

    Eating and Weight Disorders   15 ( 4 )   e226 - e233   2010.12

     More details

    Language:English  

    DOI: 10.3275/7039

  • The parenting attitudes and the stress of mothers predict the asthmatic severity of their children A prospective study Reviewed

    Nagano J, Kakuta C, Motomura C, Odajima H, Sudo N, Nishima S, Kubo C.

    BioPsychoSocial Medicine   4   2010.11

     More details

    Language:English  

    DOI: 10.1186/1751-0759-4-12

  • Relationship between snoring sound intensity and daytime blood pressure Reviewed

    Furukawa T, Nakano H, Hirayama K, Tanahashi T, Yoshihara K, Sudo N, Kubo C, Nishima S.

    Sleep and Biological Rhythms   8 ( 4 )   245 - 253   2010.10

     More details

    Language:English  

    DOI: 10.1111/j.1479-8425.2010.00455.x

  • Microbiota and brain-gut axis Reviewed

    Sudo N.

    Fukuoka igaku zasshi = Hukuoka acta medica   100 ( 9 )   298 - 304   2009.9

     More details

    Language:English  

  • [Functional somatic syndromes in the treatment of allergic diseases and their related disorders]. Reviewed

    Sudo N.

    Nippon rinsho. Japanese journal of clinical medicine   67 ( 9 )   1755 - 1758   2009.9

     More details

    Language:English  

  • Relationship between the body position-specific apnea-hypopnea index and subjective sleepiness Reviewed

    Tanaka F, Nakano H, Sudo N, Kubo C.

    Respiration   78 ( 2 )   185 - 190   2009.7

     More details

    Language:English  

    DOI: 10.1159/000208727

  • Influence of maternal bifidobacteria on the establishment of bifidobacteria colonizing the gut in infants Reviewed

    Mikami K, Takahashi H, Kimura M, Isozaki M, Izuchi K, Shibata R, Sudo N, Matsumoto H, Koga Y.

    Pediatric Research   65 ( 6 )   669 - 674   2009.6

     More details

    Language:English  

    DOI: 10.1203/PDR.0b013e31819ed7a8

  • The effects of psychological intervention on atopic dermatitis A systematic review and meta-analysis Reviewed

    Chida Y, Steptoe A, Hirakawa N, Sudo N, Kubo C.

    International Archives of Allergy and Immunology   144 ( 1 )   1 - 9   2007.8

     More details

    Language:English  

    DOI: 10.1159/000101940

  • Stress and gut microbiota Does postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response? Reviewed

    Sudo N.

    International Congress Series   1287   350 - 354   2006.4

     More details

    Language:English  

    DOI: 10.1016/j.ics.2005.12.019

  • A prospective Japanese study of the association between personality and the progression of lung cancer. Reviewed International journal

    Nagano J, Ichinose Y, Asoh H, Ikeda J, Ohshima A, Sudo N, Kubo C.

    Intern Med   45 ( 2 )   57 - 63   2006.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.45.1453

  • Social isolation stress impairs passive avoidance learning in senescence-accelerated mouse (SAM). Reviewed International journal

    Chida Y, Sudo N, Mori J, Kubo C.

    Brain Res   2006.1

     More details

    Language:English  

  • Does stress exacerbate liver diseases? Reviewed

    Chida Y, Sudo N, Kubo C.

    Journal of Gastroenterology and Hepatology (Australia)   21 ( 1 PART2 )   202 - 208   2006.1

     More details

    Language:English  

    DOI: 10.1111/j.1440-1746.2006.04110.x

  • Social disruption stress exacerbates alpha-galactosylceramide-induced hepatitis in mice. Reviewed International journal

    Sonoda J, Chida Y, Sudo N, Kubo C.

    Neuroimmunomodulation   12 ( 6 )   375 - 379   2005.12

     More details

    Language:English  

    DOI: 10.1159/000091131

  • Psychological stress impairs hepatic blood flow via central CRF receptors in mice. Reviewed International journal

    Chida Y, Sudo N, Kubo C.

    Life Sci   76 ( 15 )   1707 - 1712   2005.2

     More details

    Language:English  

    DOI: 10.1016/j.lfs.2004.08.032

  • Social isolation stress exacerbates autoimmune disease in MRL/lpr mice Reviewed International journal

    Chida Y, Sudo N, Kubo C.

    Journal of Neuroimmunology   158 ( 1-2 )   138 - 144   2005.1

     More details

    Language:English  

    DOI: 10.1016/j.jneuroim.2004.09.002

  • Electric foot-shock stress drives TNF-α production in the liver of IL-6-deficient mice Reviewed

    11 ( 6 )   419 - 424   2004.11

     More details

    Language:English  

    DOI: 10.1159/000080153

  • Dietary nucleic acid and intestinal microbiota synergistically promote a shift in the Th1/Th2 balance toward Th1-skewed immunity Reviewed International journal

    Sudo N, Aiba Y, Oyama N, Yu XN, Matsunaga M, Koga Y, Kubo C.

    International Archives of Allergy and Immunology   135 ( 2 )   132 - 135   2004.10

     More details

    Language:English  

    DOI: 10.1159/000080655

  • Psychosocial Stress, Personality, and the Severity of Chronic Hepatitis C Reviewed

    Nagano J, Nagase S, Sudo N, Kubo C.

    Psychosomatics   45 ( 2 )   100 - 106   2004.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1176/appi.psy.45.2.100

  • Endogenous glucocorticoids inhibit scratching behavior induced by the administration of compound 48/80 in mice Reviewed International journal

    Hirayama K, Sudo N, Sueyasu M, Sonoda J, Chida Y, Oishi R, Kubo C

    European Journal of Pharmacology   481 ( 1 )   59 - 65   2003.11

     More details

    Language:English  

    DOI: 10.1016/j.ejphar.2003.09.003

  • An oral introduction of intestinal bacteria prevents the development of a long-term Th2-skewed immunological memory induced by neonatal antibiotic treatment in mice Reviewed International journal

    Sudo N, Yu XN, Aiba Y, Oyama N, Sonoda J, Koga Y, Kubo C

    Clinical and Experimental Allergy   32 ( 7 )   1112 - 1116   2002.7

     More details

    Language:English  

    DOI: 10.1046/j.1365-2222.2002.01430.x

  • Restraint stress-induced elevation of endogenous glucocorticoids decreases Peyer's patch cell numbers via mechanisms that are either dependent or independent on apoptotic cell death Reviewed International journal

    Sudo N, Oyama N, Yu XN, Kubo C

    Neuroimmunomodulation   9 ( 6 )   333 - 339   2001.12

     More details

    Language:English  

    DOI: 10.1159/000059391

  • Dehydroepiandrosterone attenuates the spontaneous elevation of serum IgE level in NC/Nga mice Reviewed

    Sudo N, X. N. Yu, Kubo C.

    Immunology Letters   79 ( 3 )   177 - 179   2001.12

     More details

    Language:English  

    DOI: 10.1016/S0165-2478(01)00285-1

  • Lung cancer, myocardial infarction, and the Grossarth-Maticek personality types a case-control study in Fukuoka, Japan. Reviewed

    Nagano J, Sudo N, Kubo C, Kono S.

    Journal of Epidemiology   11 ( 6 )   281 - 287   2001.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.11.281

  • Central and peripheral catecholamines regulate the exercise-induced elevation of plasma interleukin 6 in rats Reviewed International journal

    Yu XN, Komaki G, Sudo N, Kubo C

    Life Sciences   69 ( 2 )   167 - 174   2001.6

     More details

    Language:English  

    DOI: 10.1016/S0024-3205(01)01107-9

  • Restraint stress elevates the plasma interleukin-6 levels in germ-free mice Reviewed

    Nukina H, Sudo N, Aiba Y, Oyama N, Koga Y, Kubo C.

    Journal of Neuroimmunology   115 ( 1-2 )   46 - 52   2001.4

     More details

    Language:English  

    DOI: 10.1016/S0165-5728(01)00260-0

  • Antibiotic use during infancy promotes a shift in the T(H)1/T(H)2 balance toward T(H)2-dominant immunity in mice Reviewed International journal

    Oyama N, Sudo N, Sogawa H, Kubo C

    Journal of Allergy and Clinical Immunology   107 ( 1 )   153 - 159   2001.1

     More details

    Language:English  

    DOI: 10.1067/mai.2001.111142

  • Dietary nucleic acids promote a shift in Th1/Th2 balance toward Th1-dominant immunity Reviewed International journal

    Sudo N, Aiba Y, Takaki A, Tanaka K, Yu XN, Oyama N, Koga Y, Kubo C

    Clinical and Experimental Allergy   30 ( 7 )   979 - 987   2000.7

     More details

    Language:English  

  • The restraint stress-induced elevation in plasma interleukin-6 negatively regulates the plasma TNF-alpha level Reviewed International journal

    Nukina H, Sudo N, Komaki G, Yu XN, Mine K, Kubo C

    Neuroimmunomodulation   5 ( 6 )   323 - 327   1998.11

     More details

    Language:English  

    DOI: 10.1159/000026352

  • The restraint stress-induced reduction in lymphocyte cell number in lymphoid organs correlates with the suppression of in vivo antibody production Reviewed International journal

    Fukui Y, Sudo N, Yu XN, Nukina H, Sogawa H, Kubo C

    Journal of Neuroimmunology   79 ( 2 )   211 - 217   1997.11

     More details

    Language:English  

    DOI: 10.1016/S0165-5728(97)00126-4

  • Restraint stress causes tissue-specific changes in the immune cell distribution Reviewed International journal

    Sudo N, Yu XN, Sogawa H, Kubo C

    Neuroimmunomodulation   4 ( 3 )   113 - 119   1997.5

     More details

    Language:English  

  • The serotonin-induced elevation of intracellular Ca2+ in human platelets is enhanced by total fasting Reviewed International journal

    Sudo N, Sogawa H, Komaki G, Kubo C

    Biological Psychiatry   41 ( 5 )   618 - 620   1997.3

     More details

    Language:English  

    DOI: 10.1016/S0006-3223(96)00499-4

  • Extracellular ATP activates mast cells via a mechanism that is different from the activation induced by the cross-linking of Fc receptors Reviewed International journal

    Sudo N, Tanaka K, Koga Y, Okumura Y, Kubo C, Nomoto K

    Journal of Immunology   156 ( 10 )   3970 - 3979   1996.5

     More details

    Language:English  

▼display all

Books

  • プロバイオティクスとバイオジェニクス—科学的根拠と今後の開発展望

    須藤信行( Role: Joint author)

    エヌ・ティー・エス  2007.3 

     More details

    Language:Japanese   Book type:Scholarly book

  • 臨床プレ/プロバイオティクス学入門

    古賀泰裕,須藤 信行( Role: Joint author)

    南山堂  2022.7 

     More details

    Language:Japanese  

  • 「心療内科学ーその診断から治療まで」「6.腸内細菌と脳・神経機能」

    須藤 信行( Role: Joint author)

    朝倉書店  2022.6 

     More details

    Language:Japanese  

  • 臨床プレ/プロバイオティクス学入門

    古賀 泰裕, 須藤 信行

    南山堂  2022    ISBN:9784525161217

     More details

    Language:Japanese  

    CiNii Books

  • 「BRAIN and NERVE」「脳腸相関――脳-身体の双方向性制御」

    須藤 信行( Role: Joint author)

    医学書院  2021.8 

     More details

    Language:Japanese  

  • 講座 精神疾患の臨床 第4巻 身体的苦痛症群 解離症群 心身症 食行動症または摂食症群

    須藤 信行( Role: Joint author)

    中山書店  2021.7 

     More details

    Language:Japanese  

  • 「腸内微生物叢最前線」「 5.脳腸相関と腸内微生物叢」

    須藤 信行( Role: Joint author)

    診断と治療社  2021.1 

     More details

    Language:Japanese   Book type:Scholarly book

  • 「腸内細菌と摂食障害」

    須藤 信行( Role: Joint author)

    株式会社自然科学社  2020.9 

     More details

    Language:Japanese   Book type:General book, introductory book for general audience

  • The Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota: A Target for Dietary Intervention? . The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota.

    ( Role: Joint author)

    Academic Press.  2016.6 

     More details

    Language:English   Book type:Scholarly book

  • ヒトマイクロバイオーム研究最前線

    須藤 信行(服部正平・監修), 服部 正平( Role: Joint author)

    株式会社エヌ・ティー・エス  2016.3 

     More details

    Language:Japanese   Book type:Scholarly book

  • 医科プロバイオティクス学

    須藤 信行(古賀 泰裕編)( Role: Joint author)

    シナジー  2009.10 

     More details

    Language:Japanese   Book type:Scholarly book

  • 心身医学標準テキスト(第3版)

    須藤信行( Role: Joint author)

    医学書院  2009.10 

     More details

    Language:Japanese   Book type:Scholarly book

  • プロバイオティクス・プレバイオティクス・バイオジェニックス:腸内細菌の関わりを中心としたその研究と意義.

    須藤 信行(光岡 知足編)( Role: Joint author)

    財団法人日本ビフィズス菌センター  2009.6 

     More details

    Language:Japanese   Book type:Scholarly book

  • 現代心療内科学

    須藤信行, 千田要一( Role: Joint author)

    永井書店  2003.10 

     More details

    Language:Japanese   Book type:Scholarly book

  • 心身医学標準テキスト

    須藤信行( Role: Joint author)

    医学書院  2002.7 

     More details

    Language:Japanese   Book type:Scholarly book

  • 脳機能の解明

    久保千春, 須藤信行( Role: Joint author)

    ガイア出版  2002.2 

     More details

    Language:Japanese   Book type:Scholarly book

  • Plasma IL-6 and its pyrogenicity during noninflammatory stress

    Takaki A, Hori T, Yagi S, Oka K, Kanemitsu Y, Sudo N, Shioda S, Arimura A( Role: Joint author)

    Elsevier Science  1999.1 

     More details

    Language:English   Book type:Scholarly book

▼display all

Presentations

▼display all

MISC

  • Author Correction: Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice (Scientific Reports, (2022), 12, 1, (20861), 10.1038/s41598-022-25418-5)

    Homma T., Nagata N., Hashimoto M., Iwata-Yoshikawa N., Seki N.M., Shiwa-Sudo N., Ainai A., Dohi K., Nikaido E., Mukai A., Ukai Y., Nakagawa T., Shimo Y., Maeda H., Shirai S., Aoki M., Sonoyama T., Sato M., Fumoto M., Nagira M., Nakata F., Hashiguchi T., Suzuki T., Omoto S., Hasegawa H.

    Scientific Reports   14 ( 1 )   2024.12

     More details

    Publisher:Scientific Reports  

    Correction to: Scientific Reports, published online 02 December 2022 The original version of this Article contained an error in Figure 6 where panel (e) was omitted. The original Figure 6 and accompanying legend appear below. (Figure presented.) Induction of long-term immunity in mice administered S-910823 plus A-910823. (a) Study schedule schematic. On Day 0 and Day 14, female mice were intramuscularly administered 1 μg of S-910823 with or without A-910823 (n = 5/group). Spleens and bone marrow were collected on Day 83. (b) Flow cytometric analysis of the percentage of receptor-binding domain (RBD)-specific B-cells among CD73+CD19+ B-cells. Each circle represents the percentage of cells in an individual mouse. The bars represent mean values, while error bars indicate standard deviation. (c) Detection of vaccine-induced antibody-secreting cells (ASCs) in bone marrow. Bone marrow cells were cultured for 2.5 h in an enzyme-linked immunospot (ELISPOT) assay plate wells which had been coated with SARS-CoV-2 spike protein. Results indicate the number of antigen-specific ASCs among 106 bone marrow cells. (d, e) Percentage of cytokine-producing T cells in the spleen. Splenocytes were restimulated ex vivo with or without SARS-CoV-2 spike-protein-derived peptides for 16 h. Levels of IL-2, IFN-γ, TNF-α, IL-4, and IL-5 from CD44+CD4+ T cells (d) and levels of IFN-γ from CD44+CD8+ T cells (e) were evaluated using cell-surface and intracellular staining and examined using flow cytometry. The open bars indicate non-stimulated splenocytes [peptide (−)], while the solid bars indicate splenocytes stimulated with SARS-CoV-2 spike protein peptides [peptide (+)]. The gray bars represent mice administered vehicle or S-910823 without adjuvant A-910823, while the rose bars represent mice administered S-910823 with A-910823. The open and solid circles represent the results of individual mice. The error bars indicate the standard deviation. The original Article has been corrected.

    DOI: 10.1038/s41598-024-52772-3

    Scopus

  • 内分泌代謝疾患における心身相関 肥満症における心身相関

    野崎 剛弘, 横山 寛明, 西原 智恵, 澤本 良子, 高倉 修, 小牧 元, 須藤 信行

    心身医学   64 ( 6 )   516 - 525   2024.11   ISSN:0385-0307

     More details

    Language:Japanese   Publisher:(一社)日本心身医学会  

    肥満症は,遺伝的,環境的,生理生化学的,および心理社会的・行動的要因の相互作用から生じる複雑な多因子疾患であるとみなされている.肥満症は身体疾患であるが,その発症と経過において心理社会的因子の関与が少なからずみられるため,典型的な心身症といっても過言ではない.実際,肥満症は,食行動を含む生活習慣が深く関与し,特に食行動は日常生活のストレスの影響が大きい.またうつ病,不安障害,摂食障害,睡眠障害などの精神疾患が併存する割合も高い.最近では,肥満者に対する偏見や差別(オベシティスティグマ)が肥満自体よりも,メンタルヘルスにとって悪影響を及ぼすことがわかってきている.したがって,肥満症においては,身体的側面のみならず心理社会的側面の評価とともに,両者の相互関係,すなわち心身相関への理解が不可欠となる.また肥満症の治療に当たっても心身両面からのアプローチが欠かせない.(著者抄録)

  • 【栄養を科学するイラスト解説 腸内細菌と疾患のメカニズムを探る!】脳と腸のカンケイは?

    須藤 信行

    Nutrition Care   17 ( 10 )   940 - 944   2024.10   ISSN:1882-3343

     More details

    Language:Japanese   Publisher:(株)メディカ出版  

  • 【病態生理仮説が切り開くうつ病治療の未来】脳腸相関から見たうつ病

    須藤 信行

    臨床精神薬理   27 ( 7 )   707 - 714   2024.7   ISSN:1343-3474

     More details

    Language:Japanese   Publisher:(株)星和書店  

    脳と腸は相互に影響を及ぼしあっており,この関係を脳腸相関と呼ぶ。近年,この過程に腸内細菌が重要な役割を果たしていることが明らかにされている。腸内細菌はストレス応答や行動特性に影響を及ぼすばかりでなく,精神疾患の病態形成における役割が示唆されている。うつ病の病態における腸内細菌の直接的な関与は証明されていないが,うつ病患者の腸内細菌叢は健常者と異なることが示されている。腸内細菌が神経機能に影響するメカニズムとして,神経系経路,グリア細胞,生理活性アミンなどの関与が明らかにされている。本稿では,以上の知見を基に,腸内細菌とうつ病の関連について概説した。(著者抄録)

  • 治療法の再整理とアップデートのために 専門家による私の治療 身体症状症

    須藤 信行

    日本医事新報   ( 5226 )   52 - 53   2024.6   ISSN:0385-9215

     More details

    Language:Japanese   Publisher:(株)日本医事新報社  

  • 神経科学の素朴な疑問 緊張すると咳が出るのはなぜですか?

    吉原 一文, 須藤 信行

    Clinical Neuroscience   41 ( 12 )   1652 - 1653   2023.12   ISSN:0289-0585

     More details

    Language:Japanese   Publisher:(株)中外医学社  

  • 【身体症状症 レジデントが知っておきたい診断や治療のコツ!】診断と評価 心身症

    須藤 信行

    精神科Resident   4 ( 4 )   286 - 288   2023.11   ISSN:2435-8762

     More details

    Language:Japanese   Publisher:(株)先端医学社  

  • 【心身の健康と腸内細菌の関係を探る】Dysbiosisは神経性やせ症に影響を与える

    須藤信行

    2023.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【心身の健康と腸内細菌の関係を探る】Dysbiosisは神経性やせ症に影響を与える

    須藤 信行

    Microbiome Science   2 ( 4 )   224 - 229   2023.10   ISSN:2758-2094

     More details

    Language:Japanese   Publisher:(株)先端医学社  

    摂食障害のひとつである神経性やせ症(AN)は,極端な体重減少と体重増加への恐怖を特徴とする.ANの発症と進行には心理社会的要因が重要な役割を果たしていると考えられているが,近年,宿主の代謝機能などの生物学的要因もその病態に関与していると推定されている.近年,ANでは,腸内細菌の異常,いわゆるdysbiosis,が認められることが報告され,病態形成においても重要な役割を果たしていることが示されている.本稿では,最新の研究成果をもとに,ANの発症と持続における腸内細菌の役割について概説した.(著者抄録)

  • 【性差医療の最新知識】長寿社会における性差医療各論 摂食障害と肥満

    野崎剛弘,小牧元,須藤信行

    日本臨床   2023.7

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【性差医療の最新知識】長寿社会における性差医療各論 摂食障害と肥満

    野崎 剛弘, 小牧 元, 須藤 信行

    日本臨床   81 ( 7 )   1046 - 1052   2023.7   ISSN:0047-1852

     More details

    Language:Japanese   Publisher:(株)日本臨床社  

  • 【脳腸相関UPDATE-疾患の予防と健康長寿のための食・栄養・腸環境】(Part 2)脳腸相関と疾患 うつ

    須藤信行

    臨床栄養   2023.5

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【心身症】摂食障害

    髙倉修,須藤信行

    医学と薬学   2023.5

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【脳腸相関UPDATE-疾患の予防と健康長寿のための食・栄養・腸環境】(Part 2)脳腸相関と疾患 うつ

    須藤 信行

    臨床栄養   142 ( 6 )   863 - 869   2023.5   ISSN:0485-1412

     More details

    Language:Japanese   Publisher:医歯薬出版(株)  

    <Key Point>・うつ病・うつ状態では腸内細菌叢の異常(ディスバイオーシス)が認められる.・うつ病・うつ状態患者の腸内細菌叢は,健常者と比較し,Faecalibacterium属の減少が認められることが多い.・腸内細菌がうつ病・うつ状態に影響を及ぼすメカニズムとして,迷走神経や短鎖脂肪酸,トリプトファン代謝産物の関与が想定されている.(著者抄録)

  • 神経性食欲不振症に対する強化型認知行動療法(CBT-E)と通常治療(TAU)の有効性を比較する多施設共同無作為化並行群間試験 試験実施計画書(A multi-center, randomized, parallel-group study to compare the efficacy of enhanced cognitive behavior therapy(CBT-E) with treatment as usual(TAU) for anorexia nervosa: study protocol)

    Nohara Nobuhiro, Yamanaka Yukari, Matsuoka Mikiko, Yamazaki Tadahiro, Kawai Keisuke, Takakura Shu, Sudo Nobuyuki, Ando Tetsuya, Matsuyama Yutaka, Byrne Susan, Grave Riccardo Dalle, Cooper Zafra, Yoshiuchi Kazuhiro

    Biopsychosocial Medicine   17   1 of 8 - 8 of 8   2023.5

     More details

    Language:English   Publisher:(一社)日本心身医学会  

  • 【心身症】摂食障害

    高倉 修, 須藤 信行

    医学と薬学   80 ( 5 )   483 - 489   2023.4   ISSN:0389-3898

     More details

    Language:Japanese