記述言語：英語  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1053/j.gastro.2008.03.005

記述言語：英語  

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DOI： 10.1136/gut.2004.058818

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DOI： 10.1113/jphysiol.2004.063388

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DOI： 10.1002/hep.20158

記述言語：英語  

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記述言語：英語   出版者・発行元：Eating and Weight Disorders  

Purpose: The Eating Attitude Test-26 (EAT-26) is a screening tool for eating disorders (EDs) in clinical and non-clinical samples. The cut-off score was suggested to be varied according to target population. However, no studies have examined the appropriateness of the originally proposed score of 20 for screening DSM-5 eating disorders in Japan. This study aimed to identify an appropriate cut-off score to better differentiate clinical and non-clinical samples in Japan for EDs. Methods: The participants consisted of 54 patients with anorexia nervosa restricting type, 58 patients with anorexia nervosa binge-eating/purging type, 37 patients with bulimia nervosa diagnosed according to DSM-5 criteria, and 190 healthy controls (HCs). Welch’s t test was used to assess differences in age, body mass index (BMI), and total EAT-26 scores between HCs and patients with EDs. Receiver operating characteristic (ROC) analysis was conducted to identify the optimal cut-off score. Results: The HCs had significantly higher BMI and lower total EAT-26 mean scores than patients with EDs. The area under the ROC curve was 0.925, indicating that EAT-26 had excellent performance in discriminating patients with EDs from HCs. An optimal cut-off score of 17 was identified, with sensitivity and specificity values of 0.866 and 0.868, respectively. Conclusions: The result supports the suggestions that optimal cut-off score should be different according to target populations. The newly identified cut-off score of 17 would enable the identification of patients with EDs who have been previously classified as non-clinical samples in the EAT-26 test. Level of evidence: III: evidence obtained from case–control analytic study.

DOI： 10.1007/s40519-024-01669-1

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記述言語：英語   出版者・発行元：Frontiers in Pain Research  

Introduction: In psychotherapy, it is important to establish and deepen a therapeutic trusting relationship, but patients who have experienced extreme adversity in childhood tend to have difficulty in building such a relationship. This paper reports a case of fibromyalgia with adverse childhood experiences (ACEs) in which a nonverbal approach was successful in building a trusting relationship. Case and methods: The patient is a woman in her late 40s. She had strong anger rooted in ACEs, including neglect by her father, a feeling of unfair parenting by her mother compared to her younger brother, overcontrol of her life by her mother, and sexual abuse by her uncle. She was filled with strong interpersonal distrust and anger, and the experience of an unsuccessful surgery compounded her distrust of medical care. The therapist initially had severe difficulty in verbal interaction with the patient. When conducting “drawing” therapy, she ignored the therapist's comments and completely blacked out the drawing paper. However, the patient-therapist relationship gradually changed, and verbal interaction became possible through the use of nonverbal approaches such as framing her drawing paper and “Towel Baby Holding.” Results: The therapist was able to understand the patient's emotions through these nonverbal approaches and to communicate with the patient that she understood her feelings. This approach was also successful in the patient’s understanding of her own pathology. The patient became able to honestly express her feelings in words, which eventually enabled her to be introduced to mindfulness therapy, leading to a favorable treatment course. Conclusion: For patients with ACEs, a nonverbal approach helps build a therapeutic relationship and plays an important role in understanding the patient.

DOI： 10.3389/fpain.2024.1374324

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記述言語：英語   出版者・発行元：Journals of Gerontology - Series A Biological Sciences and Medical Sciences  

Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1 201 community-dwelling Japanese aged =65 years. Regional gray matter volumes (GMV) and intracranial volume (ICV) were estimated by applying voxel-based morphometry (VBM) methods. The associations of serum NT-proBNP with regional GMV/ICV were examined by analysis of covariance. The regional gray matter atrophy patterns associated with elevated serum NT-proBNP levels were investigated using VBM without a priori regions of interest. The multivariable-adjusted means of the frontal, temporal, hippocampal, parahippocampal, and entorhinal GMV/ICV decreased significantly with elevated serum NT-proBNP levels (all p for trend and q values of false discovery rate correction < .05). In VBM, elevated serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral entorhinal areas, bilateral fusiform gyri, left middle temporal gyrus, left inferior temporal gyrus, right central operculum, right posterior orbital gyrus, bilateral middle frontal gyri, anterior cingulate gyrus and bilateral medial frontal cortices. In a sensitivity analysis excluding 254 participants with mild cognitive impairment or dementia, serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral fusiform gyri, and left middle frontal gyrus. Our data suggest that elevated serum NT-proBNP levels are associated with gray matter atrophy in brain regions that play an important role in cognitive function.

DOI： 10.1093/gerona/glae075

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1093/gerona/glae075.

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/ejp.2224.

記述言語：英語   出版者・発行元：European Journal of Pain (United Kingdom)  

Background: Autonomic nervous system dysfunction has been reported to be associated with impaired activities of daily living (ADL) among patients with chronic pain, but the association has not been fully addressed in general populations. This study cross-sectionally investigated the association between autonomic nervous system function and the presence of subjective symptoms affecting ADL in community-dwelling residents with chronic pain. Methods: A total of 888 residents with chronic pain, aged 40–79 years, who underwent a health examination in 2017–2018 were included. Based on heart rate variability measured by fingertip pulse wave, the standard deviation of normal-to-normal intervals (SDNN), root mean square of successive RR interval differences (RMSSD), low frequency (LF) power, and high frequency (HF) power were calculated. Symptoms affecting ADL were defined as those scoring ≥1 on the modified Rankin Scale. Odds ratios (ORs) and their 95% confidence intervals (CIs) for symptoms affecting ADL were estimated using a logistic regression analysis. Results: The overall prevalence of symptoms affecting ADL was 39.4%. The ORs for symptoms affecting ADL increased significantly per 1-standard-deviation decrement in log-transformed SDNN (OR 1.23 [95% CI 1.06–1.44]), RMSSD (1.25 [1.08–1.45]), LF power (1.29 [1.11–1.52]), and HF power (1.29 [1.11–1.51]) after adjusting for age, sex, education, hypertension, diabetes, serum total cholesterol level, body mass index, past medical history, current smoking, current drinking, exercise, depressive symptoms, and pain intensity. Conclusions: Decreased heart rate variability was associated with the presence of symptoms affecting ADL among individuals with chronic pain in a Japanese community. Significance: Decrease in heart rate variability was associated with the presence of symptoms affecting ADL among individuals with chronic pain in a Japanese community. This article could help scientists understand the significance of autonomic nervous system dysfunction in the pathology of chronic pain. Approaches that target autonomic nervous system dysfunction may be an option to relieve or prevent symptoms affecting ADL for chronic pain sufferers.

DOI： 10.1002/ejp.2224

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記述言語：英語   出版者・発行元：PLoS ONE  

Recent evidence suggests a crucial role of the gut microbiota in the pathogenesis of anorexia nervosa (AN). In this study, we carried out a series of multiple analyses of the gut microbiota of hospitalized individuals with AN over three months using 16S or 23S rRNA-targeted reverse transcription-quantitative polymerase chain reaction (PCR) technology (YIF-SCAN®), which is highly sensitive and enables the precise quantification of viable microorganisms. Despite the weight gain and improvements in psychological features observed during treatment, individuals with AN exhibited persistent gut microbial dysbiosis over the three-month duration. Principal component analysis further underscored the distinct microbial profile of individuals with AN, compared with that of age-matched healthy women at all time points. Regarding the kinetics of bacterial detection, the detection rate of Lactiplantibacillus spp. significantly increased after inpatient treatment. Additionally, the elevation in the Bifidobacterium counts during inpatient treatment was significantly correlated with the subsequent body weight gain after one year. Collectively, these findings suggest that gut dysbiosis in individuals with AN may not be easily restored solely through weight gain, highlighting the potential of therapeutic interventions targeting microbiota via dietary modifications or live biotherapeutics. Copyright:

DOI： 10.1371/journal.pone.0296037

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.14814/phy2.15882.

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0296037.

記述言語：英語   出版者・発行元：Physiological Reports  

1-Kestose (KES), a dietary fiber and prebiotic carbohydrate, benefits various physiological functions. This study aimed to examine whether diets supplemented with KES over three consecutive generations could significantly affect some host physiological aspects, including behavioral phenotypes and gut microbial ecology. Mice that received KES-supplemented diets for three generations demonstrated increased activity compared with those fed diets lacking KES. Furthermore, the KES group showed increased striatal dopamine (DA) and serotonin (5-HT) levels. The observed increase in DA levels within the striatum was positively correlated with locomotor activity in the KES group but not in the control (CON) group. The α-diversities were significantly lower in the KES group compared to the CON group. The three-dimensional principal coordinate analysis revealed a substantial distinction between the KES and CON groups across each generation. At the genus level, most gut microbiota genera exhibited lower abundances in the KES group than in the CON group, except for Bifidobacteria and Akkermansia. Spearman's rank-order analysis indicated significant negative correlations between the striatal DA levels and α-diversity values. These findings suggest that prolonged supplementation with KES may stimulate increased locomotor activity along with elevated striatal DA levels, which are potentially associated with KES-induced alterations in the gut microbiota.

DOI： 10.14814/phy2.15882

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記述言語：英語   出版者・発行元：BMC Endocrine Disorders  

Following publication of the original article [1], the authors reported an error in the number of participants in Fig. 2. The original Fig. 2 was: The updated Fig. 2 should read: The original article [1] has been updated.

DOI： 10.1186/s12902-023-01513-0

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記述言語：英語   出版者・発行元：BioPsychoSocial Medicine  

Background: Previous studies have shown that patients with Coronavirus Disease 2019 (COVID-19) are likely to be affected by delirium and other psychiatric complications. We aimed to evaluate the relation between COVID-19 vaccination status and referral of patients hospitalized with COVID-19 for consultation–liaison psychiatry services. Method: From the medical records used for this retrospective, single hospital-based study, 576 patients were identified who were over 18 years-of-age and hospitalized with a diagnosis of COVID-19 between March 2020 and March 2022. The data of 531 for whom the vaccine history was obtained from the medical records were available for analysis: 455 without and 76 with referral to consultation–liaison psychiatry. A history of COVID-19 vaccination at least two times was used in the analysis of the odds for referral to liaison psychiatric consultation: 95% confidence interval (CI) in multivariable logistic regression. The adjustment factors included sex, age, body mass index (BMI), severity of COVID-19, C-reactive protein level, medical history, and therapeutic factors such as the use of remdesivir, steroids, or mechanical ventilation. Results: The prevalence of psychiatric consultation was 14.3%. Patients without vaccination had a 7-times greater OR (95%CI:2.08–23.58) than vaccinated patients for a referral for consultation–liaison psychiatry services after adjusting for confounding factors. Conclusion: Non-vaccination was associated with a greater likelihood of referral for consultation–liaison psychiatry service among these hospitalized Japanese patients with COVID-19, even after adjusting for clinical and therapeutic factors. It is possible that vaccination greatly lessens the need for the referral of COVID-19 patients for consultation–liaison psychiatry services.

DOI： 10.1186/s13030-023-00296-z

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13030-023-00296-z.

記述言語：英語   出版者・発行元：(一社)日本心身医学会  

記述言語：英語   出版者・発行元：BioPsychoSocial Medicine  

Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with psychiatric symptoms such as anxiety and depression. It has been reported that FM patients engage in pain catastrophizing. In this study, we investigated characteristics of the brain volume of female FM patients and the association between psychological indices and brain volume. Thirty-nine female FM patients and 25 female healthy controls (HCs) were recruited for the study, and five FM patients were excluded due to white matter lesions. The following analyses were performed: (1) T1-weighted MRI were acquired for 34 FM patients (age 41.6 ± 7.4) and 25 HCs (age 39.5 ± 7.4). SPM12 was used to compare their gray and white matter volumes. (2) Data from anxiety and depression questionnaires (State-Trait Anxiety Inventory and Hospital Anxiety and Depression Scale), the Pain Catastrophizing Scale (subscales rumination, helplessness, magnification), and MRI were acquired for 34 FM patients (age 41.6 ± 7.4). Correlation analysis was done of the psychological indices and brain volume. We found that (1) The white matter volume of the temporal pole was larger in the FM patient group than in the HC group. (2) Correlation analysis of the psychological indices and gray matter volume showed a negative correlation between trait anxiety and the amygdala. For the white matter volume, positive correlations were found between depression and the brainstem and between magnification and the postcentral gyrus. Changes in the brain volume of female FM patients may be related to anxiety, depression, and pain catastrophizing.

DOI： 10.1186/s13030-023-00293-2

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記述言語：英語   出版者・発行元：BMC Endocrine Disorders  

Objective: To investigate associations between parenting styles during childhood and diabetes in adulthood in a Japanese community. Methods: In 2011, 710 community-dwelling Japanese residents aged ≥ 40 years were assessed for the presence of diabetes and for their perceptions of the parenting style of their parents, as measured using the “care” and “overprotection” scales of the Parental Bonding Instrument. Care and overprotection scores for each parent were dichotomized by age-specific median values. Diabetes mellitus was defined as a fasting plasma glucose level of ≥ 7.0 mmol/L, a 2-h post-loaded glucose level of ≥ 11.1 mmol/L, HbA1c ≥ 6.5%, and/or the current use of insulin or oral glucose-lowering agents. The odds ratios (ORs) for prevalent diabetes were calculated using a logistic regression model. Results: The prevalence of diabetes was 14.9%. Subjects with a high paternal overprotection score had a significantly greater likelihood of prevalent diabetes than those with a low paternal overprotection score after adjusting for confounders (OR 1.71, 95% confidence interval [CI] 1.06–2.77), while there was no significant association between paternal care and diabetes. Additionally, the multivariable-adjusted ORs for the presence of diabetes were significantly higher in subjects with a low maternal care score (OR 1.61, 95%CI 1.00–2.60) or in subjects with a high maternal overprotection score (OR 1.73, 95%CI 1.08–2.80). Moreover, the subjects with a low care score and high overprotection score for both their father and mother had a significantly higher multivariable-adjusted OR of diabetes than those with a high care score and low overprotection score for both parents (OR 2,12, 95%CI 1.14–3.95). Conclusions: This study suggests that inadequate care and excessive overprotection during childhood may contribute to the development of diabetes in adulthood.

DOI： 10.1186/s12902-023-01474-4

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13030-023-00293-2.

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12902-023-01474-4.

記述言語：英語   出版者・発行元：(一社)日本心身医学会  

線維筋痛症(FM)の女性患者34名および女性健常対照25名を対象に、T1強調MRIと画像解析ソフトウェアSPM12を用いて灰白質および白質容積を測定した。FM患者の状態-特性不安尺度(STAI)、病院不安抑鬱尺度(HADS)および痛みの破局的思考尺度(PCS)を評価した。FM患者群の側頭極白質容積は対照群と比べて大きかった。心理学的指標と灰白質容積の相関分析の結果、特性不安と扁桃体の間に負相関がみられた。白質容積に関して、HADSで評価される抑鬱と脳幹の間、およびPCSで評価される拡大視と中心後回の間に正相関がみられた。以上の結果から、女性FM患者の脳容積変化が不安、抑鬱および痛みの破局化と関連すると考えられた。

記述言語：英語   出版者・発行元：Journal of Physiological Anthropology  

Background: Alexithymia, a personality trait characterized by difficulties in identifying and expressing their emotions despite having a range of emotional experiences, can impact individuals’ stress coping mechanisms. While many studies have investigated brain functions associated with specific tasks in relation to emotion processing, research focusing on resting-state brain functions has been limited. Thus, the aim of this study was to investigate the relationship between alexithymia and brain function by analyzing arterial spin labeling (ASL) data obtained during the resting state. Methods: A brain structural and functional imaging study was conducted on 42 healthy adult men and women using ASL and the 20-item Toronto Alexithymia Scale (TAS-20) questionnaire survey. Cerebral blood flow and functional connectivity values were calculated for regions of interest in the default mode network, saliency network, and central executive network from the ASL data. Correlation analysis was performed with TAS20 scores, and partial correlation analysis was conducted to control for anxiety and depression. Results: The functional connectivity analysis revealed a negative correlation between the functional connectivity of the right insular cortex and left anterior cingulate cortex and the total score of TAS, as well as difficulty identifying feelings and difficulty describing feeling subscores, indicating that the higher the scores, the weaker the functional connectivity between these regions (T = -3.830, p = 0.0013, R = -0.5180). This correlation remained significant even after controlling for anxiety and depression using partial correlation analysis. Conclusion: The present study revealed differences in the activity of the Saliency Network at rest as measured by ASL, which were independent of anxiety and depression, and varied depending on the severity of alexithymia. This functional change may underlie the neural basis of decreased emotional processing observed in alexithymia. These findings may contribute to the elucidation of the neural mechanisms of alexithymia, which can lead to social impairments, and suggest the usefulness of ASL measurement as a biomarker of alexithymia.

DOI： 10.1186/s40101-023-00336-1

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s40101-023-00336-1.

記述言語：英語   出版者・発行元：(一社)日本生理人類学会  

失感情症と脳機能の関係について安静時に取得した動脈スピンラベリング(ASL)データの解析による検討を行った。健常成人42人(男性14人、女性28人、平均31.2±9.5歳)を対象として、ASLと20-item Toronto Alexithymia Scale(TAS-20)アンケート調査を用いて脳の構造及び機能イメージング研究を行った。ASLデータから、デフォルトモードネットワーク、salience network及びセントラルエグゼクティブネットワークにおける関心領域に対する脳血流及び機能的結合の値を算出した。機能的結合分析により、右島皮質及び左前帯状皮質の機能的結合と、TAS-20のトータルスコア、感情を特定することの困難さ、感情を語ることの困難さのサブスコアに負の相関がみられた。これらのスコアが高いほどこれらの領域間の機能的結合は弱くなった。この相関は偏相関分析を用いて不安及び抑鬱を調整した後でも有意であった。

記述言語：英語   出版者・発行元：Journal of Eating Disorders  

Background: Few studies have examined the economic costs of outpatient care for eating disorders in Japan. This study aimed to clarify the reimbursement for outpatient treatment of eating disorders and compare the costs between the departments of Psychosomatic Medicine and Psychiatry in Japan. Method: A multicenter, prospective, observational study of patients with an eating disorder was conducted in the Psychosomatic Medicine departments of three centers and the Psychiatry departments of another three centers in Japan. We analyzed medical reimbursement for an outpatient revisit, time of clinical interviews, and the treatment outcome measured by the Eating Disorder Examination Questionnaire (EDE-Q) global scores and body mass index (BMI) at 3 months. Multivariate linear regression models were performed to adjust for covariates. Results: This study included 188 patients in the Psychosomatic Medicine departments and 68 in the Psychiatry departments. The average reimbursement cost for an outpatient revisit was 4670 yen. Even after controlling for covariates, the Psychosomatic Medicine departments had lower reimbursement points per minute of interviews than the Psychiatry departments (coefficient = − 23.86; 95% confidence interval = − 32.09 to − 15.63; P < 0.001). In contrast, EDE-Q global scores and BMI at 3 months were not significantly different between these departments. Conclusions: This study clarifies the economic costs of treating outpatients with eating disorders in Japan. The medical reimbursement points per interview minute were lower in Psychosomatic Medicine departments than in Psychiatry departments, while there were no apparent differences in the treatment outcomes. Addressing this issue is necessary to provide an adequate healthcare system for patients with eating disorders in Japan.

DOI： 10.1186/s40337-023-00864-2

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s40337-023-00864-2.

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13030-023-00279-0.

記述言語：英語   出版者・発行元：PLoS ONE  

The psychopathology of patients with anorexia nervosa has been hypothesized to involve inappropriate self-referential processing, disturbed interoceptive awareness, and excessive cognitive control, including distorted self-concern, disregard of their own starvation state, and extreme weight-control behavior. We hypothesized that the resting-state brain networks, including the default mode, salience and frontal-parietal networks, might be altered in such patients, and that treatment might normalize neural functional connectivity, with improvement of inappropriate self-cognition. We measured resting-state functional magnetic resonance images from 18 patients with anorexia nervosa and 18 healthy subjects before and after integrated hospital treatment (nourishment and psychological therapy). The default mode, salience, and frontal-parietal networks were examined using independent component analysis. Body mass index and psychometric measurements significantly improved after treatment. Before treatment, default mode network functional connectivity in the retrosplenial cortex and salience network functional connectivity in the ventral anterior insula and rostral anterior cingulate cortex were decreased in anorexia nervosa patients compared with those in controls. Interpersonal distrust was negatively correlated with salience network functional connectivity in the rostral anterior cingulate cortex. Default mode network functional connectivity in the posterior insula and frontal-parietal network functional connectivity in the angular gyrus were increased in anorexia nervosa patients compared with those in controls. Comparison between pre- and post-treatment images from patients with anorexia nervosa exhibited significant increases in default mode network functional connectivity in the hippocampus and retrosplenial cortex, and salience network functional connectivity in the dorsal anterior insula following treatment. Frontal-parietal network functional connectivity in the angular cortex showed no significant changes. The findings revealed that treatment altered the functional connectivity in several parts of default mode and salience networks in patients with anorexia nervosa. These alterations of neural function might be associated with improvement of self-referential processing and coping with sensations of discomfort following treatment for anorexia nervosa.

DOI： 10.1371/journal.pone.0283318

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記述言語：英語   出版者・発行元：BioPsychoSocial Medicine  

Background: The superiority of Enhanced Cognitive Behavior Therapy (CBT-E) with regard to weight gain and improvement of psychopathology of eating disorders for patients with anorexia nervosa (AN) over other psychotherapies and treatment as usual (TAU) has not been demonstrated in randomized controlled trials (RCTs). However, a previous RCT showed that patients with AN whose baseline body mass index (BMI) was less than 17.5 kg/m2 gained more weight when treated with CBT-E than with other psychotherapies. The aim of the study is to compare the efficacy of CBT-E and TAU for patients with AN. It was hypothesized that CBT-E would be superior to TAU, at least in terms of weight gain, as most patients with AN are likely to have a BMI lower than 17.5 kg/m2. Methods/design: A randomized parallel-group multicenter trial will be conducted in three teaching hospitals in Japan between January 2023 and March 2026. Patients with DSM-5 AN, aged 16 years and older, with a BMI equal to or above 14.0 and below 18.5 will be eligible to participate. 56 patients will be randomly and evenly assigned to two intervention groups (CBT-E and TAU). Those assigned to CBT-E will be offered 25–40 sessions in accordance with their initial BMI. Patients assigned to TAU will have at least one session every 2 weeks, with the number of sessions and treatment period not fixed in advance. The primary outcome is BMI at 40 weeks after treatment initiation. The secondary outcomes are the results from the Japanese version of the Eating Disorder Examination Questionnaire and Clinical Impairment Assessment questionnaire to measure eating disorder psychopathology and psychological impairment. The follow-up assessment will be performed 6 months after the 40-week assessment. Discussion: This multi-center randomized controlled study will probably evaluate the efficacy of CBT-E compared with TAU for patients with more severe AN than in previous studies since Japanese patients are likely to have a lower BMI than those in Western countries. While it may be difficult to generalize the results of a study conducted in Japan, it would be valuable to clarify the efficacy of CBT-E as a treatment package. Trial registration: UMIN, UMIN000048847. Registered 12 Sep 2022.

DOI： 10.1186/s13030-023-00277-2

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出版者・発行元：医歯薬出版(株)  

DOI： 10.32118/j01532.2023220961

CiNii Research

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0283318.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13030-023-00277-2.

記述言語：英語   出版者・発行元：BioPsychoSocial Medicine  

Background: Psychological distress has been frequently observed in frontline healthcare workers under stress during the coronavirus disease 2019 (COVID-19) epidemic; however, it is unclear if there are differences in the stress and symptoms experienced by staff members who work exclusively in a COVID-19 ward and support staff temporarily deployed to a COVID-19 ward. The present study investigated psychosocial stress specific to the care for patients with COVID-19 and psychological distress among ward staff working exclusively with COVID-19 and temporary support staff. Methods: The participants were full-time nurses and doctors working in COVID-19 wards or the ICU who provided face-to-face care to patients with COVID-19 during the COVID-19 outbreak in February of 2021. The data of 67 staff members (21 exclusively working with Covid-19 patients (group A) and 46 in the temporary support group (group B)) was available for study. Psychosocial stress specific to healthcare professionals during this COVID-19 outbreak (Tokyo Metropolitan Distress Scale for Pandemic [TMDP]) and general psychological distress (K6) were assessed. Results: The K6 score was significantly lower in group B than in group A (p =.006), but no significant difference was found in the total score of TMDP or its subscales. Positive correlations were found between TMDP and K6 for group B (p =.011), as was the number of days of care on TMDP-social (rs =.456, p =.001). Conclusion: Even though support staff members experienced lower psychological distress than staff working exclusively with COVID-19, COVID-19-related psychosocial stress specific to HCWs was comparable. The support staff also presented psychological distress associated with psychosocial stress specific to healthcare professionals during this COVID-19 outbreak, and the COVID-19-related social stress was enhanced as the number of working days increased. Our results show that all staff, not only those working exclusively with COVID-19 patients but also other support staff should be provided with care focusing on COVID-19-related psychosocial occupational stress.

DOI： 10.1186/s13030-023-00272-7

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13030-023-00272-7.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/ejp.2076.

記述言語：英語   出版者・発行元：(一社)日本心身医学会  

COVID-19患者のケアに特異的な心理社会的ストレス、COVID-19専属病棟従事者と支援従事者の精神的苦痛について調査した。被験者は2021年2月のCOVID-19流行下におけるCOVID-19病棟の看護師と医師で、専任従事者67名(A群)と一時的なサポート従事者46名(B群)であった。COVID-19流行における医療従事者に特有な心理社会的ストレス(Tokyo Metropolitan Distress Scale for Pandemic[TMDP])とgeneral psychological distress(K6)を評価した。K6スコアはA群よりもB群で有意に低かったが、TMDPの総合スコアと下位尺度で有意差はなかった。B群ではTMDPとK6に正相関が認められ、TMDP-社会項目に対するケア日数でも正相関が認められた。COVID-19専属従事者よりも支援従事者のほうが精神的苦痛は弱かったが、心理社会的ストレスはほぼ同等であった。支援従事者でも精神的苦痛が認められ、従事日数増加とともに社会的ストレスが増大した。

記述言語：英語   出版者・発行元：European Journal of Pain (United Kingdom)  

Background: Poor family functioning has been reported to be associated with the severity of chronic pain in outpatients, but the association has not been fully addressed in general populations. The present study aimed to examine the association between family dysfunction levels and the presence of chronic pain in a community-dwelling Japanese population. Methods: A total of 2598 participants aged ≥40 years were classified as having healthy, borderline or unhealthy family functioning. Chronic pain was defined as subjective pain for three months or longer, and further classified by pain intensity, the number of chronic pain sites, pain duration and the extent of pain spread. A logistic regression model was used to compute the odds ratios (ORs) for chronic pain outcomes. Results: The prevalence of chronic pain was 49%. The age- and sex-adjusted prevalence of total and severe chronic pain were increased significantly with increasing family dysfunction levels (all p for trend <0.01). After adjusting for sociodemographic, physical, social and family structure factors, the ORs (95% confidence intervals [CI]) for having chronic pain among borderline and unhealthy groups were 1.20 (1.01–1.44) and 1.43 (1.15–1.79), respectively, as compared with a healthy family function group. The association was stronger among people who were employed and those who were living with their children. In addition, the ORs for severe chronic pain increased significantly with increasing levels of family dysfunction. Conclusions: The family dysfunction level was positively associated with the presence as well as the severity of chronic pain in a community-dwelling population. Significance: A biopsychosocial burden due to family relationships could worsen the clinical presentation of pain. Social support or family therapy for dysfunctional families would be a potential initiative for the prevention or management of chronic pain.

DOI： 10.1002/ejp.2076

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記述言語：英語   出版者・発行元：Medicine (United States)  

This study aimed to identify occupational stress, psychosomatic symptoms, psychological distress, and their correlations among frontline nurses during and after the first peak of the coronavirus disease 2019 (COVID-19) outbreak in Japan. Sixteen frontline nurses, aged 25 to 52 years, working in a ward with COVID-19 patients participated in this study. Two months after the peak of the first wave of the COVID-19 outbreak in Japan, the COVID-19-related occupational stress scale (COS; questionnaire items: fear of infection and increased workload) and physical symptom scale (PS; questionnaire items: gastrointestinal symptoms, pain, appetite loss, and insomnia) were assessed. The degree of general psychological distress was evaluated using the 6-item Kessler Scale (K6). Simultaneously, participants were asked to recall their condition during the peak period of the first wave and rate it using the same scale. K6 was positively correlated with COS and PS during the peak period (rs=0.574, P=.020 and rs=0.587, P=.017, respectively). Increased workload was positively correlated with the K6 score both during and after the peak period (rs=0.869, P<.001 and rs=0.732, P = <.001, respectively) and was positively correlated with insomnia during the peak period (rs=0.498, P<.05). The COS, PS, and K6 scores during the peak period were significantly higher than those after the peak period. Psychological distress at the peak was associated with PS and occupational stress. An increased workload during peak periods can cause psychological distress and insomnia. The occupational stress, PS, and psychological distress of nurses working in COVID-19 wards improved after the peak of COVID-19.

DOI： 10.1097/MD.0000000000031687

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/MD.0000000000031687.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s40519-022-01492-6.

記述言語：日本語   出版者・発行元：日本慢性疼痛学会  

【背景】「慢性疼痛のアクセプタンス」は慢性疼痛の理解や治療のための重要な概念とされている。その測定にはChronic Pain Acceptance Questionnaireが最も使用されている。本研究の目的はCPAQ日本語版(CPAQ-J)の作成,その妥当性の検討であった。【方法】慢性疼痛患者243人を対象とし,CPAQ-Jおよび痛みの強度,機能障害,不安,抑うつ,痛みの破局化,生活の質,生活満足度につき回答してもらった。【結果】CPAQ-Jはスクリープロット,主因子法により英語原版と同様の2因子構造を示し,十分な内的整合性(Cronbach α係数0.83)と再検査信頼性(級内相関係数0.88)が示された。また,痛みの強度,機能障害,不安,抑うつ,痛みの破局化,生活の質,生活満足度と有意な関連を認めた。【結論】本研究でCPAQ-Jは我が国の慢性疼痛患者において,十分な信頼性と妥当性が示された。(著者抄録)

記述言語：英語   出版者・発行元：Eating and Weight Disorders  

Purpose: Patients with anorexia nervosa (AN) require appropriate nutrient therapy and physical activity management. Eating disorder treatment guidelines do not include safe, evidence-based intensity criteria for exercise. This study used cardiopulmonary exercise testing (CPX) to evaluate the exercise tolerance of patients with AN. Methods: CPX was performed with 14 female patients with AN admitted to a specialized eating disorder unit between 2015 and 2019. Their anaerobic threshold (AT) was determined by assessing their exercise tolerance using CPX and compared with 14 healthy controls (HC). The metabolic equivalents (AT-METS) were compared when AT was reached. We examined factors related to AT (AN-AT) in the AN group, including age, body mass index (BMI), previous lowest weight, minimum BMI, past duration of BMI < 15, exercise history, and ΔHR (heart rate at the AT—resting heart rate). Results: The AT of the AN group (BMI: 15.7 [Mean] ± 1.8 standard deviation [SD]) was significantly lower than that of the HC group (BMI: 19.7 ± 1.8) (AN: 10.0 ± 1.8 vs. HC: 15.2 ± 3.0 ml/kg/min, P < 0.001). AT-METS was also significantly lower in the AN group than in the HC group (AN: 2.9 ± 0.52 vs. HC: 4.4 ± 0.91, P < 0.001). AN-AT was highly influenced by ΔHR. Conclusions: This study showed that AT and AT-METS were lower in patients with AN than in HC. Patients with AN should be prescribed light-intensity aerobic exercise, and the current findings may help develop future physical management guidelines for patients with AN. Level of evidence: III: Evidence obtained from case–control analytic studies.

DOI： 10.1007/s40519-022-01492-6

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出版者・発行元：Scientific Reports  

Vaccines that efficiently target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease (COVID-19), are the best means for controlling viral spread. This study evaluated the efficacy of the COVID-19 vaccine S-268019-b, which comprises the recombinant full-length SARS-CoV-2 spike protein S-910823 (antigen) and A-910823 (adjuvant). In addition to eliciting both Th1-type and Th2-type cellular immune responses, two doses of S-910823 plus A-910823 induced anti-spike protein IgG antibodies and neutralizing antibodies against SARS-CoV-2. In a SARS-CoV-2 challenge test, S-910823 plus A-910823 mitigated SARS-CoV-2 infection-induced weight loss and death and inhibited viral replication in mouse lungs. S-910823 plus A-910823 promoted cytokine and chemokine at the injection site and immune cell accumulation in the draining lymph nodes. This led to the formation of germinal centers and the induction of memory B cells, antibody-secreting cells, and memory T cells. These findings provide fundamental property of S-268019-b, especially importance of A-910823 to elicit humoral and cellular immune responses.

DOI： 10.1038/s41598-022-25418-5

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記述言語：英語   出版者・発行元：Pain  

Chronic low back pain (CLBP) is the leading cause of years lived with disability. Recently, it has been reported that CLBP is associated with alterations in the central nervous system. The present study aimed to investigate the association between CLBP and regional brain atrophy in an older Japanese population. A total of 1106 community-dwelling participants aged ≥65 years underwent brain magnetic resonance imaging scans and a health examination in 2017 to 2018. We used the FreeSurfer software for the analysis of brain magnetic resonance imaging. Chronic pain was defined as subjective pain for ≥3 months. Participants were divided into 3 groups according to the presence or absence of chronic pain and the body part that mainly suffered from pain: a "no chronic pain (NCP)" group (n = 541), "CLBP" group (n = 189), and "chronic pain in body parts other than the lower back (OCP)" group (n = 376). The brain volumes of the ventrolateral and dorsolateral prefrontal cortex, the posterior cingulate gyrus, and the amygdala were significantly lower in the CLBP group than in the NCP group after adjustment for sociodemographic, physical, and lifestyle factors and depressive symptoms. In addition, the left superior frontal gyrus was identified as a significant cluster by the Query, Design, Estimate, Contrast interface. There were no significant differences in the brain volumes of pain-related regions between the NCP and the OCP groups. The present study suggests that CLBP is associated with lower brain volumes of pain-related regions in a general older population of Japanese.

DOI： 10.1097/j.pain.0000000000002612

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記述言語：日本語   出版者・発行元：(NPO)日本心療内科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本心療内科学会  

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記述言語：英語   出版者・発行元：Frontiers in Psychiatry  

Background: Cognitive behavioral therapy (CBT) has become one of the most commonly used psychotherapeutic treatments for obesity. It stems from CBT for bulimia nervosa and binge eating disorder, which focuses on amelioration of the eating behavior and body image dissatisfaction (BID), but usually does not focus on weight loss. In contrast, CBT for obesity focuses on weight loss, as well as eating behavior and BID. It is at present unclear whether the improvement of BID during CBT for obesity is associated with improvement of factors other than weight loss. Objective: The purpose of this study was to determine whether improvement of BID during CBT for obesity was associated with improvement of factors other than weight loss. Methods: One hundred and sixty-five women (BMI 31.8 ± 5.2 kg/m2, age 49.3 ± 10.5 years) with overweight or obesity completed a 7-month CBT-based weight loss intervention. BID, depression, anxiety, binge eating, and perfectionism were assessed at both baseline and the end of the intervention through the use of psychological questionnaires. Results: Percent total weight loss, baseline BID, baseline binge eating disorder (BED), change in depression (Δdepression), Δstate anxiety, Δtrait anxiety, Δbinge eating, and Δperfectionism were significantly correlated with ΔBID. Multiple regression analysis showed that baseline BID, baseline BED, percent total weight loss, Δbinge eating, and Δdepression were independently associated with ΔBID. Conclusion: Improvement of binge eating, and improvement of depression, as well as weight loss, were independently associated with amelioration of BID. Clinical trial registration: [https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000008052], identifier [UMIN000006803] and [https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R0000 55850], identifier [UMIN000049041].

DOI： 10.3389/fpsyt.2022.1025946

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fpsyt.2022.1025946.

記述言語：日本語   出版者・発行元：(NPO)日本心療内科学会  

摂食障害は強迫性との関連が指摘されている。神経性過食症患者に対して,公認心理師が摂食障害に特化した治療法である拡大版認知行動療法(Enhanced Cognitive Behavior Therapy:CBT-E)を実施し,症状改善とともに強迫性にも改善が見られた1症例を報告する。症例は20代女性。CBT-Eのプロトコルに基づき,セルフモニタリングや規則正しい食事の確立等により過食症状は改善した。また,中核の精神病理を扱う中で,自身の完全主義的な傾向に気づき,「肩の力を抜くように」と生活にも変化が生じた。摂食障害評価質問票(EDE-Q),臨床的障害評価法(CIA)による自己評価でも,治療前後でスコアが改善した。CBT-Eは摂食障害の過食嘔吐の症状改善に有効であるだけでなく,治療による行動変容を通して,強迫性に苦慮していた患者が自身の生活や生き方を見直す契機にもなり得る。CBT-Eの実施にあたっては,公認心理師がCBT-Eを行い,それに併せて主治医が通常診療を行うという構造が現実的であり,また治療を促進するメリットもあると考えられる。(著者抄録)

出版者・発行元：Vaccine  

To control the coronavirus disease 2019 (COVID-19) pandemic, there is a need to develop vaccines to prevent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. One candidate is a nasal vaccine capable of inducing secretory IgA antibodies in the mucosa of the upper respiratory tract, the initial site of infection. However, regarding the development of COVID-19 vaccines, there is concern about the potential risk of inducing lung eosinophilic immunopathology as a vaccine-associated enhanced respiratory disease as a result of the T helper 2 (Th2)-dominant adaptive immune response. In this study, we investigated the protective effect against virus infection induced by intranasal vaccination of recombinant trimeric spike protein derived from SARS-CoV-2 adjuvanted with CpG oligonucleotides, ODN2006, in mouse model. The intranasal vaccine combined with ODN2006 successfully induced not only systemic spike-specific IgG antibodies, but also secretory IgA antibodies in the nasal mucosa. Secretory IgA antibodies showed high protective ability against SARS-CoV-2 variants (Alpha, Beta and Gamma variants) compared to IgG antibodies in the serum. The nasal vaccine of this formulation induced a high number of IFN-γ-secreting cells in the draining cervical lymph nodes and a lower spike-specific IgG1/IgG2a ratio compared to that of subcutaneous vaccination with alum as a typical Th2 adjuvant. These features are consistent with the induction of the Th1 adaptive immune response. In addition, mice intranasally vaccinated with ODN2006 showed less lung eosinophilic immunopathology after viral challenge than mice subcutaneously vaccinated with alum adjuvant. Our findings indicate that intranasal vaccine adjuvanted with ODN2006 could be a candidate that can prevent the infection of antigenically different variant viruses, reducing the risk of vaccine-associated enhanced respiratory disease.

DOI： 10.1016/j.vaccine.2022.08.049

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記述言語：日本語   出版者・発行元：(公社)日本精神神経学会  

わが国の矯正施設では近年摂食障害(ED)の受刑者が増加し,女子刑務所などの現場では対応に大変苦慮している.重篤で一般刑務所では対応困難な症例は,医療刑務所に移送される.北九州医療刑務所(以下,当所)では,患者の受け入れを2012年5月より開始し集約的な治療を行ってきた.【目的】当所に入所した100人の神経性やせ症(AN)女性患者を分類し比較することにより,その病態理解を進める.【方法】矯正施設初回入所以前の,EDの病歴と覚醒剤乱用歴の有無により,「ED病歴(+)覚醒剤歴(-)」群,「ED病歴(-)覚醒剤歴(-)」群,「覚醒剤歴(+)ED病歴(+)」群,「覚醒剤歴(+)ED病歴(-)」群に分類し,人口統計学的,臨床的,心理社会的データの比較を行った.【結果】大多数を占めたのは「ED病歴(+)覚醒剤歴(-)」群(n=74)であり,若くして典型的なEDを発症しきわめて長い病歴をもった,重症遷延性神経性やせ症(SEAN)であった.「ED病歴(-)覚醒剤歴(-)」群(n=13)は,中高年になり逮捕や収容を契機にEDを出現させていた.「覚醒剤歴(+)ED病歴(-)」群(n=9)は,矯正施設収容以後に,ほぼ矯正施設内限定でEDの症状を出現させていた.「ED病歴(-)覚醒剤歴(-)」群と「覚醒剤歴(+)ED病歴(-)」群は非典型的なEDの病像を示し,やせ願望は比較的軽度であった.重篤で長いED病歴をもつ「ED病歴(+)覚醒剤歴(-)」群においても,矯正施設初回入所以前にED治療を受けた者は,約半数にすぎなかった.【考察】ANの女性受刑者は均一の集団ではなく,治療や対応はそれぞれの病態に適合させる必要があるため,これらの分類は治療のために有益である.「ED病歴(+)覚醒剤歴(-)」群は,数の多さからもEDの典型性や重篤性からも臨床的に特に重要である.医療刑務所のAN患者の病態や治療について,今後も系統的多面的に研究を進め,報告する予定である.(著者抄録)

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2337/dc21-1911.

記述言語：英語   出版者・発行元：Diabetes Care  

OBJECTIVE To examine the association between diabetes and gray matter atrophy patterns in a general older Japanese population. RESEARCH DESIGN AND METHODS In 2012, a total of 1,189 community-dwelling Japanese aged ≥65 years underwent brain MRI scans. Regional gray matter volumes (GMV) and intracranial volume (ICV) were measured by applying voxel-based morphometry (VBM) methods. The associations of diabetes and related parameters with the regional GMV/ICV were examined using an ANCOVA. The regional gray matter atrophy patterns in the subjects with diabetes or elevated fasting plasma glucose (FPG) or 2-h postload glucose (2hPG) levels were investigated using VBM. RESULTS Subjects with diabetes had significantly lower mean values of GMV/ICV in the frontal lobe, temporal lobe, insula, deep gray matter structures, and cerebellum than subjects without diabetes after adjusting for potential confounders. A longer duration of diabetes was also significantly associated with lower mean values of GMV/ICV in these brain regions. The multivariable-adjusted mean values of the temporal, insular, and deep GMV/ICV decreased significantly with elevating 2hPG levels, whereas higher FPG levels were not significantly associated with GMV/ICV of any brain regions. In the VBM analysis, diabetes was associated with gray matter atrophy in the bilateral superior temporal gyri, right middle temporal gyrus, left inferior temporal gyrus, right middle frontal gyrus, bilateral thalami, right caudate, and right cerebellum. CONCLUSIONS The current study suggests that a longer duration of diabetes and elevated 2hPG levels are significant risk factors for gray matter atrophy in various brain regions.

DOI： 10.2337/dc21-1911

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記述言語：日本語   出版者・発行元：日本交流分析学会  

慢性疲労症候群(CFS)患者のエゴグラムと精神症状の関連について明らかにすることを目的に、A病院心療内科に入院したCFS患者34名(男性8名、女性26名、平均年齢34.6±14.7歳)を対象に、東大式エゴグラムバージョンII(TEGII)、抑うつ状態自己評価尺度(CES-D)、症状チェックリスト(SCL-90-R)を実施した。TEGIIのFC(自由な子どもの自我状態)の得点と抑うつ、強迫症状、対人過敏の得点との関連を検討した結果、FCと強迫症状、FCと対人過敏のそれぞれの間で、有意な負の相関がみられたほか、FCと抑うつの間にも負の相関が認められ、有意ではないものの、有意傾向にあった。また、TEGIIのAC(適応的な子どもの自我状態)の得点と抑うつ、強迫症状、対人過敏の得点との関連を検討した結果、ACと抑うつ、ACと強迫症状、ACと対人過敏のそれぞれの間で、有意な正の相関がみられた。

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/j.pain.0000000000002612.

記述言語：英語   出版者・発行元：Frontiers in Psychiatry  

Background: Modern-Type Depression (MTD) is a category of depression that has been studied mainly in Japan; however, no study has attempted to determine its relation to chronic pain. Aim: To determine possible associations between psychological traits related to MTD and the chronic pain of patients at psychiatric clinics. Method: Two hundred and twenty-one first time patients who visited the psychiatric clinic at a Japanese university medical center or an associated clinic were enrolled. The Hamilton Depression Rating Scale was used to measure depressive symptoms. The 22-item Tarumi's Modern-Type Depression Trait Scale (TACS-22), Achievement Motive, and 20-item Toronto Alexithymia Scale were used to assess psychological traits related to depression and chronic pain. The clinical diagnosis of each patient was confirmed by use of the Structured Clinical Interview for DSM-IV Axis I Disorders, administered by experienced specialists. The medians of the psychological traits identified were compared between patients with or without chronic pain. Analysis was also done of patients with Major Depressive Disorder (MDD). Result: Of the 221 patients, 139 had chronic pain. Patients with chronic pain had more severe depressive symptoms, Alexithymia, and high scores for the complaint trait of MTD. Seventy-three of the 221 patients met the criteria for MDD (53 had chronic pain). Patients with MDD comorbid with chronic pain had a higher competitive achievement score, severe depression, and difficulty identifying feelings. Conclusion: Complaint and competitive traits were shown to be related to chronic pain in psychiatric settings. Further study will allow us to design multidimensional approach for patients suffering from depression.

DOI： 10.3389/fpsyt.2022.825422

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Physiology and Behavior  

Important precursors of monoaminergic neurotransmitters, dietary tryptophan (TRP), tyrosine, and phenylalanine (all referred to as TTP), play crucial roles in a wide range of behavioral and emotional functions. In the current study, we investigated whether diets devoid of TTP or diets deficient in TRP alone can affect body weight, behavioral characteristics, and gut microbiota, by comparing mice fed on these amino acids-depleted diets to mice fed on diets containing regular levels of amino acids. Both dietary TTP- and TRP-deprived animals showed a reduction in food intake and body weight. In behavioral analyses, the mice fed TTP-deprived diets were more active than mice fed diets containing regular levels of amino acids. The TRP-deprived group exhibited a reduction in serum TRP levels, concomitant with a decrease in serotonin and 5-hydroxyindoleacetic acid levels in some regions of the brain. The TTP-deprived group showed a reduction in TTP levels in the serum, concomitant with decreases in both phenylalanine and tyrosine levels in the hippocampus, as well as serotonin, norepinephrine, and dopamine concentrations in some regions of the brain. Regarding the effects of TRP or TTP deprivation on gut microbial ecology, the relative abundance of genus Roseburia was significantly reduced in the TTP-deprived group than in the dietary restriction control group. Interestingly, TTP was found even in the feces of mice fed TTP- and TRP-deficient diets, suggesting that TTP is produced by microbial or enzymatic digestion of the host-derived proteins. However, microbe generated TTP did not compensate for the systemic TTP deficiency induced by the lack of dietary TTP intake. Collectively, these results indicate that chronic dietary TTP deprivation induces decreased monoamines and their metabolites in a brain region-specific manner. The altered activities of the monoaminergic systems may contribute to increased locomotor activity.

DOI： 10.1016/j.physbeh.2021.113653

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fpsyt.2022.825422.

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.physbeh.2021.113653.

記述言語：英語   出版者・発行元：BioPsychoSocial Medicine  

Following publication of the original article [1], the authors identified an error in Fig. 3 and Table 6. In the old Fig. 3, there was a layout problem in the upper right part of the figure. The word “tests” in the sentence “7 were fit. But it had completed outpatient PRISM and pain-related tests” was out of the box. In the old Table 6, eight respondents were shown for the two questions, each person’s comment consisted of two comment parts before (T0) and after (T1). The old table cannot distinguish between them. The author put the replaced shapes in the table in the extended metafile so that it wouldn’t get out of shape. The correct figure and table have been included in this correction, and the original article has been corrected.

DOI： 10.1186/s13030-021-00230-1

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PubMed

記述言語：英語   出版者・発行元：BioPsychoSocial Medicine  

Background: The COVID-19 pandemic and associated lockdown had a considerable impact on eating disorders (EDs). We evaluated the clinical features of Japanese ED patients before and after the first COVID-19 outbreak-related state of emergency (April 7, 2020). Methods: We studied 148 patients who were divided into two groups based on when they arrived at our clinic: before (Before group: n = 86) or after (After group: n = 62) the start of the first state of emergency. All patients completed the Japanese versions of the Eating Disorder Inventory (EDI) and Parental Bonding Instrument (PBI). Results: The After group was substantially younger than the Before group (p =.0187). Regardless of the ED type, patients who developed an ED during the first state of emergency tended to be significantly younger than those who developed one before. Differences in EDI characteristics were observed between the two groups. The PBI care subscale was notably higher (p =.0177) in the After group. The PBI maternal care subscale was the only statistically significant factor associated with age (β = -0.35, p <.0001). Conclusions: Home confinement associated with the COVID-19 pandemic and the ensuing increase in parent-child closeness may have influenced the decreased age of ED patients at their initial consultation. Treatment interventions should consider the differences in the clinical features of EDs.

DOI： 10.1186/s13030-021-00232-z

Web of Science

Scopus

PubMed

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13030-021-00232-z.

記述言語：英語   出版者・発行元：(一社)日本心身医学会  

COVID-19パンデミックといろいろな制限による摂食障害(ED)患者への影響を調べるため、第1回緊急事態宣言発出(2020年4月7日)前後のED患者の臨床的特徴を比較した。宣言前に九州大学心療内科に来院した患者86名(前群)とその後に来院した患者62名(後群)を比較した。Eating Disorder Inventory(EDI)とParental Bonding Instrument(PBI)を用いた自己記入調査を行った。後群は前群よりもかなり若かった。EDの型に関係なく、宣言発出前にED発症した患者よりも宣言中に発症した患者のほうが有意に若い傾向があった。両群でEDIの特徴に相異が観察された。PBI養育サブスケールが後群でかなり高かった。PBI母性保護サブスケールのみが、年齢と関連する因子であった。

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： doi: 10.1186/s13030-021-00223-0.

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/GME.0000000000001840.

記述言語：英語  

DOI： 10.1016/j.jpsychores.2021.110422

記述言語：英語  

DOI： 10.1016/j.physbeh.2020.113204.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.physbeh.2020.113004

記述言語：英語  

DOI： 10.1186/s13030-020-00192-w

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13030-020-00194-8

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/MD.0000000000021230

記述言語：英語  

DOI： 10.1186/s13030-020-00186-8

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13030-020-0174-z

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DOI： 10.1186/s13030-019-0173-0

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DOI： 10.1159/000502236

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記述言語：英語  

DOI： 10.12938/bmfh.19-006

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DOI： 10.1186/s13030-017-0099-3

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DOI： 10.1016/j.neuroimage.2016.04.040

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DOI： 10.1016/j.neuroimage.2012.07.025

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DOI： 10.1111/j.1399-5448.2010.00708.x

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DOI： 10.1016/j.ics.2005.12.019

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DOI： 10.1016/S0006-3223(96)00499-4

記述言語：英語  

記述言語：日本語  

記述言語：日本語   著書種別：学術書

記述言語：日本語   著書種別：一般書・啓蒙書

記述言語：英語   著書種別：学術書

記述言語：日本語   著書種別：学術書

記述言語：日本語   著書種別：学術書

記述言語：日本語   著書種別：学術書

記述言語：日本語   著書種別：学術書

記述言語：日本語   著書種別：学術書

記述言語：日本語   著書種別：学術書

記述言語：日本語   著書種別：学術書

記述言語：英語   著書種別：学術書

開催年月日： 2022年5月

記述言語：日本語   会議種別：口頭発表（招待・特別）  

開催地：東京都   国名：日本国  

開催年月日： 2022年3月

記述言語：日本語  

国名：インドネシア共和国  

開催年月日： 2021年11月

記述言語：日本語  

開催地：岡崎市   国名：日本国  

開催年月日： 2021年9月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：秋田県秋田市   国名：日本国  

開催年月日： 2021年3月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡市   国名：日本国  

開催年月日： 2020年11月

記述言語：日本語  

開催地：岡崎市   国名：日本国  

記述言語：日本語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

開催地：オンライン   国名：日本国  

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：オンライン   国名：日本国  

記述言語：日本語  

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記述言語：日本語  

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記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   出版者・発行元：(株)先端医学社  

摂食障害のひとつである神経性やせ症(AN)は,極端な体重減少と体重増加への恐怖を特徴とする.ANの発症と進行には心理社会的要因が重要な役割を果たしていると考えられているが,近年,宿主の代謝機能などの生物学的要因もその病態に関与していると推定されている.近年,ANでは,腸内細菌の異常,いわゆるdysbiosis,が認められることが報告され,病態形成においても重要な役割を果たしていることが示されている.本稿では,最新の研究成果をもとに,ANの発症と持続における腸内細菌の役割について概説した.(著者抄録)

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   出版者・発行元：(株)日本臨床社  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   出版者・発行元：医歯薬出版(株)  

＜Key Point＞・うつ病・うつ状態では腸内細菌叢の異常(ディスバイオーシス)が認められる.・うつ病・うつ状態患者の腸内細菌叢は,健常者と比較し,Faecalibacterium属の減少が認められることが多い.・腸内細菌がうつ病・うつ状態に影響を及ぼすメカニズムとして,迷走神経や短鎖脂肪酸,トリプトファン代謝産物の関与が想定されている.(著者抄録)

記述言語：英語   出版者・発行元：(一社)日本心身医学会  

記述言語：日本語   出版者・発行元：(株)自然科学社  

記述言語：日本語   出版者・発行元：日本自律訓練学会  

記述言語：日本語   出版者・発行元：大道学館出版部  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   出版者・発行元：(公社)日本精神神経学会  

記述言語：日本語   出版者・発行元：大道学館出版部  

記述言語：日本語   出版者・発行元：(一社)日本肥満学会  

肥満人口は世界的に増加しており、本邦でも成人の4人に1人がBMI≧25kg/m2である。肥満は糖尿病を始め、脂質異常症、高血圧症、非アルコール性脂肪肝炎などの合併症を引き起こす。内科的治療が効果を示さなかった高度肥満症に対しては減量・代謝改善手術が適応となる。しかし、術後において長期的にみると約30%の症例が目標体重に達しないか、または体重再増加が起こる。その背景には種々の心理的行動的要因が関与しているといわれる。中でも食事療法の非遵守、2つ以上の精神疾患の併存、過食性障害、だらだら食いといった食行動異常などが挙げられている。したがって、術後の目標体重の未達成、体重再増加の防止のためには、その心理的行動的要因に対する評価と治療的介入が必要となる。介入方法として、認知行動療法、対人関係療法、弁証法的行動療法、アクセプタンス&コミットメント・セラピー(Acceptance and commitment therapy:ACT)、マインドフルネスに基づく食観トレーニング(Mindfulness-based eating awareness training:MB-EAT)などの心理的行動的アプローチが報告されている。減量・代謝改善手術においては、心理的行動的要因に対する術前の慎重な診断・評価とともに、心理療法を含む集学的治療が必要であると考える。(著者抄録)

記述言語：日本語   出版者・発行元：大道学館出版部  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：英語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語  

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

参加者数：200

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

参加者数：350

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：査読等 

外国語雑誌　査読論文数：5

日本語雑誌　査読論文数：10

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

参加者数：1,000

種別：大会・シンポジウム等 

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種別：学会・研究会等 

種別：査読等 

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種別：大会・シンポジウム等 

種別：学会・研究会等 

種別：査読等 

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種別：査読等 

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