Updated on 2024/07/28

Information

 

写真a

 
AGO TETSURO
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Associate Professor
School of Medicine Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medical Sciences(Joint Appointment)
Title
Associate Professor
Contact information
メールアドレス
Profile
基礎研究 微小血管レベルにおける血管と神経・グリアの相互作用(Neurovascular unit)を念頭に, 脳血管障害・認知症・てんかん・頭痛の発生機序や脳傷害後の組織修復・機能回復の分子細胞機序に関する研究を行っている. また, 生体内における活性酸素種の産生および消去メカニズムとそれらによって生じる心血管病(動脈硬化・心肥大・心不全・脳血管障害・認知症)発症制御機構についての研究を行っている. 臨床研究 福岡県内脳血管障害急性期主要関連7施設と共同で脳卒中データベース研究(The Fukuoka Stroke Registry, FSR)を行っている。 脳血管障害の疫学研究に加え, ゲノムならびに血漿の採取を行い脳血管障害に関連する遺伝子の探索, バイオマーカー研究を行っている. 機能転帰を決定しうる臨床的因子の同定に力を入れている. 臨床 大学病院における脳血管障害の急性期・慢性期診療を行っている. 脳卒中のみならず, 認知症, てんかん, 頭痛などの主要脳疾患, また脳血管障害にならないための生活習慣病の管理を得意とする. 学内では救急ホットライン, 他科コンサルトにも積極的に対応している.
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Degree

  • MD, PhD

Research Interests・Research Keywords

  • Research theme:Molecular mechanisms of repair and regeneration in brain after cerebrovascular diseases

    Keyword:brain infarction, neural repair/regeneration, endothelial cells, pericytes, glia, macrophages

    Research period: 2008.4

  • Research theme:Exploration of genetic factors and biomarkers of cerebrovascular diseases

    Keyword:brain infarction, biomarker, genes, proteins

    Research period: 2008.4

  • Research theme:Multicenter hospital-based prospective study of acute stroke (Acute stroke cohort study; Fukuoka stroke Registry).

    Keyword:stroke database, multi-centered trial

    Research period: 2008.4

  • Research theme:Roles of Redox (oxidative stress) in regulating cardiovascular diseases

    Keyword:redox, NADPH oxidase, antioxidants, atherosclerosis

    Research period: 2001.4

  • Research theme:Elucidation of activation mechanisms of phagocyte NADPH oxidase

    Keyword:Phagocyte NADPH oxidase

    Research period: 1996.4 - 2002.3

Awards

  • 日本脳循環代謝学会・学会賞

    2018.11   日本脳循環代謝学会  

  • The Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigators

    2007.11   American Heart Association  

  • 上原記念生命科学財団・海外留学リサーチフェローシップ

    2007.3   上原記念生命科学財団  

  • AHA postdoctoral fellowship

    2006.10   AHA  

  • Oxygen Club of Greater Washington DC Young Investigator Award

    2006.10  

  • 上原記念生命科学財団・海外留学リサーチフェローシップ

    2005.3   上原記念生命科学財団  

  • 貝原守一医学振興財団・研究助成賞

    2005.3   貝原守一医学振興財団  

  • 動脈硬化update・研究奨励賞

    2004.10   日本心臓財団「動脈硬化update2004」  

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Papers

  • PDGFRβ-positive cell-mediated post-stroke remodeling of fibronectin and laminin α 2 for tissue repair and functional recovery. Reviewed International journal

    43 ( 4 )   518 - 530   2023.4

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  • Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice Reviewed International journal

    @Yamanaka K, @Nakamura K, @Shibahara T, @Takashima M, @Takaki H, @Hidaka M, @Komori M, @Yoshikawa Y, @Wakisaka Y, @Ago T, @Kitazono T

    Glia   2023.3

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  • beta-Cell Function and Clinical Outcome in Nondiabetic Patients With Acute Ischemic Stroke Invited Reviewed International journal

    @Kiyohara T, @Matsuo R, @Hata J, @Nakamura K, @Wakisaka Y, @Kamouchi M, @Kitazono T, @Ago T

    STROKE   52 ( 8 )   2621 - 2628   2021.8

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    DOI: 10.1161/STROKEAHA.120.031392

  • Reciprocal Interaction Between Pericytes and Macrophage in Poststroke Tissue Repair and Functional Recovery Invited Reviewed International journal

    Shibahara T, Ago T, et al.

    STROKE   51 ( 10 )   3095 - 3106   2020.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.120.029827

  • Pericyte-Mediated Tissue Repair through PDGFRbeta Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke Reviewed International journal

    Shibahara T, Ago T, et al.

    eNeuro   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/ENEURO.0474-19.2020

  • Smoking Status and Functional Outcomes After Acute Ischemic Stroke Invited Reviewed International journal

    Matsuo R, Ago T, et al.

    STROKE   51 ( 3 )   846 - 852   2020.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.119.027230

  • Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier Reviewed

    Kuniyuki Nakamura, Tomoko Ikeuchi, Kazuki Nara, Craig S. Rhodes, Peipei Zhang, Yuta Chiba, Saiko Kazuno, Yoshiki Miura, Tetsuro Ago, Eri Arikawa-Hirasawa, Yoh Suke Mukouyama, Yoshihiko Yamada

    The Journal of cell biology   218 ( 10 )   3506 - 3525   2019.10

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    DOI: 10.1083/jcb.201807178

  • Early initiation of a factor Xa inhibitor can attenuate tissue repair and neurorestoration after middle cerebral artery occlusion Reviewed

    Motohiro Komori, Tetsuro Ago, Yoshinobu Wakisaka, Kuniyuki Nakamura, Masaki Tachibana, Yoji Yoshikawa, Tomoya Shibahara, Kei Yamanaka, Junya Kuroda, Takanari Kitazono

    Brain Research   1718   201 - 211   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.brainres.2019.05.020

  • Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury Reviewed

    Yoji Yoshikawa, Tetsuro Ago, Junya Kuroda, Yoshinobu Wakisaka, Masaki Tachibana, Motohiro Komori, Tomoya Shibahara, Hideyuki Nakashima, Kinichi Nakashima, Takanari Kitazono

    Neuroscience   398   193 - 205   2019.2

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    DOI: 10.1016/j.neuroscience.2018.11.046

  • ペリサイトは脳機能にとってなぜ重要なのか? Reviewed

    59 ( 11 )   707 - 715   2019.1

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    Pericytes are mural cells embedded in the basal membrane surrounding endothelial cells in capillary and small vessels (from precapillary arterioles to postcapillary venules). They exist with a high coverage ratio to endothelial cells in the brain and play crucial roles in the formation and maintenance of the blood-brain barrier and the control of blood flow through a close interaction with endothelial cells. Thus, intactness of pericyte is absolutely needed for neuronal/ brain functions. Ageing, life-style diseases, hypoperfusion/ischemia, drugs, and genetic factors can primarily cause pericyte dysfunctions, thereby leading to the development or progression of various brain disorders, including cerebrovascular diseases. Because pericytes also play an important role in tissue repair after brain injuries, they have received much attention as a therapeutic target even from the standpoint of functional recovery.

    DOI: 10.5692/clinicalneurol.cn-001357

  • Insulin resistance and clinical outcomes after ischemic stroke. Reviewed International journal

    Ago T, Matsuo R, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M. Insulin resistance and clinical outcomes after ischemic stroke.

    Neurology   90 ( 17 )   1470 - 1477   2018.5

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  • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes Reviewed

    Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne Katrin Giese, Sander W. Van Der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H.H. Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Adam S. Butterworth, Caty Carrera, Cara L. Carty, Daniel I. Chasman, Wei Min Chen, John W. Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul I.W. De Bakker, Anita L. Destefano, Marcel Den Hoed, Qing Duan, Stefan T. Engelter, Guido J. Falcone, Rebecca F. Gottesman, Raji P. Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B. Harris, Ahamad Hassan, Aki S. Havulinna, Susan R. Heckbert, Elizabeth G. Holliday, George Howard, Fang Chi Hsu

    Nature genetics   50 ( 4 )   524 - 537   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41588-018-0058-3

  • Early reperfusion after brain ischemia has beneficial effects beyond rescuing neurons Reviewed International journal

    Tachibana M, Ago T, Wakisaka Y, Kuroda J, Kitazono T

    Stroke   2017.8

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  • Detrimental role of pericyte Nox4 in the acute phase of brain ischemia. Reviewed International journal

    Nishimura A, Ago T, Kuroda J, et al.

    J Cereb Blood Flow Metab   36 ( 6 )   1143 - 1154   2016.6

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  • Possible involvement of basic FGF in the upregulation of PDGFR beta in pericytes after ischemic stroke Reviewed International journal

    Nakamura K, Arimura K, Ago T, et al.

    BRAIN RESEARCH   1630   98 - 108   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.brainres.2015.11.003

  • Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke

    2015.2

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    Language:English  

  • Brain pericyte in health and cerebrovascular diseases.

    Ago T, Kitazono T

    2014.6

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    Language:Japanese  

  • Neurotrophin production in brain pericytes during hypoxia: a role of pericytes for neuroprotection Reviewed International journal

    Ishitsuka K, Ago T(Corresponding author), Arimura K, Nakamura K, Tokami H, Makihara N, Kuroda J, Kamouchi M, Kitazono T.

    Microvascular Research   83 ( 3 )   2012.5

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  • PDGF receptor β signaling in pericytes following ischemic brain injury Reviewed International journal

    9 ( 1 )   2012.2

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  • NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Reviewed International journal

    Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD, Sadoshima J

    PNAS   107 ( 35 )   2010.8

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  • Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes. Reviewed International journal

    Ago T, Kuroda J, Pain J, Fu C, Li H, Sadoshima J.

    Circulation Research   2010.4

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  • A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Reviewed International journal

    Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, Vatner SF, Sadoshima J.

    Cell   2008.6

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  • NAD(P)H oxidases in rat basilar arterial endothelial cells Reviewed International journal

    Ago T, Kitazono T, Kuroda J, Kumai Y, Kamouchi M, Ooboshi H, Wakisaka M, Kawahara T, Rokutan K, Ibayashi S, Iida M

    Stroke   36 ( 5 )   1040 - 1046   2005.5

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    DOI: 10.1161/01.STR.0000163111.05825.0b

  • Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase. Reviewed International journal

    Ago T, Kitazono T, Ooboshi H, Iyama T, Han YH, Takada J, Wakisaka M, Ibayashi S, Utsumi H, Iida M.

    Circulation   109 ( 2 )   227 - 233   2004.1

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    DOI: 10.1161/01.CIR.0000105680.92873.70

  • Phosphorylation of p47phox directs PX domain from SH3 domain towards phosphoinositides, leading to phagocyte NADPH oxidase activation. Reviewed International journal

    Ago T, Kuribayashi F, Hiroaki H, Takeya R, Ito T, Kohda D, Sumimoto H.

    PNAS   100 ( 8 )   4474 - 4479   2003.4

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    DOI: 10.1073/pnas.0735712100

  • Solution structure of the PX domain, a target of the SH3 domain. International journal

    Hiroaki H, Ago T, Ito T, Sumimoto H, Kohda D.

    Nature Structural Biology   8 ( 6 )   526 - 530   2001.8

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    DOI: 10.1038/88591

  • Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47phox. Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47phox, thereby activating the oxidase. Reviewed International journal

    Ago T, Nunoi H, Ito T, Sumimoto H.

    J Biol Chem   274 ( 47 )   33644 - 33653   1999.11

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    DOI: 10.1074/jbc.274.47.33644

  • Body temperature in the acute phase and clinical outcomes after acute ischemic stroke. Reviewed International journal

    Mezuki S, Matsuo R, Irie F, Shono Y, Kuwashiro T, Sugimori H, Wakisaka Y, Ago T, Kamouchi M, Kitazono T

    PLoS One   19 (1) ( e0296639 )   1 - 16   2024.1

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    DOI: 10.1371/journal.pone.0296639

  • Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke. Reviewed International journal

    Wakisaka K, Matsuo R, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T.

    PLoS One   19 (1) ( e0296833 )   1 - 16   2024.1

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    DOI: doi.org/10.1371/journal.pone.0296833

  • Sex Differences in Long-Term Functional Decline after Ischemic Stroke: A Longitudinal Observational Study from the Fukuoka Stroke Registry. Reviewed International journal

    @Irie F, @Matsuo R, @Nakamura K, @Wakisaka Y, @Ago T, @Kitazono T, @Kamouchi M

    Cerebrovascular diseases (Basel, Switzerland)   1 - 8   2023.9

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    DOI: 10.1159/000526940

  • Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke. Reviewed International journal

    Nakamura K, Ueki K, Matsuo R, Kiyohara T, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T.

    PLoS One   18 (6) ( e0287721 )   1 - 17   2023.6

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    DOI: doi.org/10.1371/journal.pone.0287721

  • Decreased estimated glomerular filtration rate and proteinuria and long-term outcomes after ischemic stroke: a longitudinal observational cohort study. Reviewed International journal

    @Ueki K, @Matsuo R, @Kuwashiro T, @Irie F, @Wakisaka Y, @Ago T, @Kamouchi M, @Kitazono T.

    Stroke   2023.5

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  • Non-linear association between body weight and functional outcome after acute ischemic stroke. Reviewed International journal

    Wakisaka K, Matsuo R, Matsumoto K, Nohara Y, Irie F, Wakisaka Y, Ago T, Nakashima N, Kamouchi M, Kitazono T.

    Sci Rep   13 ( 8697 )   1 - 10   2023.3

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    DOI: 10.1038/s41598-023-35894-y

  • Modification of the effects of age on clinical outcomes through management of lifestyle-related factors in patients with acute ischemic stroke Reviewed International journal

    Ohya Y, Matsuo R, Sato N, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T.

    J Neurol Sci   446 ( 120589 )   1 - 7   2023.3

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    DOI: 10.1016/j.jns.2023.120589

  • Stroke genetics informs drug discovery and risk prediction across ancestries. Reviewed International journal

    Mishra A, Malik R, Hachiya T, Ago T, et al.

    Nature   2022.9

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  • Causes of ischemic stroke in young adults versus non-young adults: a multicenter hospital-based observational study. Reviewed International journal

    @Ohya Y, @Matsuo R, @Sato N, @Irie F, @Nakamura K, @Wakisaka Y, @Ago T, @Kamouchi M, @Kitazono T.

    PLoS One   2022.7

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  • Low-dose sodium-glucose cotransporter 2 inhibitor ameliorates ischemic brain injury in mice through pericyte protection without glucose-lowering effects. Reviewed International journal

    @Takashima M, @Nakamura K, @Kiyohara T, @Wakisaka Y, @Hidaka M, @Takaki H, @Yamanaka K, @Shibahara T, @Wakisaka M, @Ago T, @Kitazono T

    Commun Biol   5 ( 1 )   653 - 653   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-022-03605-4

  • Association between Early Cognitive Impairment and Short-Term Functional Outcome in Acute Ischemic Stroke Invited Reviewed International journal

    Kiyohara T, Kumai Y, Yubi T, Ishikawa E, Wakisaka Y, Ago T, Kitazono T.

    Cerebrovasc Dis   2022.6

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  • Filamin A Variant as a Possible Second-Hit Gene Promoting Moyamoya Disease-Like Vascular Formation associated with RNF213 p.R4810K Variant. Reviewed International journal

    @Ikeuchi Y, @Kitayama J, @Sahara N, @Okata T, @Miyake N,@Matsumoto N, @Kitazono T, @Ago T

    Neurology:Genetics   8 ( 5 )   2022.5

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  • Long-Term Trends in The 5-Year Risk of Recurrent Stroke over A Half Century in A Japanese Community: The Hisayama Study. Reviewed International journal

    Nakanishi Y, Furuta Y, Hata J, Yubi T, Oishi E, Sakata S, Hirakawa Y, Wakisaka Y, Ago T, Kitazono T, Ninomiya T.

    J Atheroscler Thromb   29   2022.2

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  • Day-by-day blood pressure variability in the subacute stage of ischemic stroke and long-term recurrence Invited Reviewed International journal

    Fukuda K, Matsuo R, Kamouchi M, Kiyuna F, Sato N, Hata J, Ago T, Imaizumi T, Kai H, Kitazono T.

    STROKE   2021.10

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  • Sex differences in the risk of 30-day death after acute ischemic stroke Invited Reviewed International journal

    Irie F, Matsuo R, Nakamura K, Wakisaka Y, Ago T, Kamouchi M, Kitazono T

    Neurol Clin Pract   2021.10

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  • Pre-stroke cholinesterase inhibitor treatment is beneficially associated with functional outcome in patients with acute ischemic stroke and pre-stroke dementia: the Fukuoka Stroke Registry. Invited Reviewed International journal

    Wakisaka Y, Matsuo R, Nakamura K, Ago T, Kamouchi M, Kitazono T

    Cerebrovasc Dis   50 ( 4 )   390 - 396   2021.4

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  • Nationwide temporal trend analysis of reperfusion therapy utilization and mortality in acute ischemic stroke patients in Japan Invited Reviewed International journal

    Maeda M, Fukuda H, Matsuo R, Kiyuna F, Ago T, Kitazono T, Kamouchi M

    MEDICINE   100 ( 1 )   2021.1

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    DOI: 10.1097/MD.0000000000024145

  • Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia-reperfusion injury Invited Reviewed International journal

    Okahara A, Koga J, Matoba T, Fujiwara M, Tokutome M, Ikeda G, Nakano K, Tachibana M, Ago T, Kitazono T, Tsutsui H, Egashira K

    SCIENTIFIC REPORTS   10 ( 1 )   2020.9

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    DOI: 10.1038/s41598-020-71326-x

  • Association between anticoagulation therapy and risk of stroke recurrence in ESUS patients without potential embolic source identified Invited Reviewed International journal

    Sato N, Matsuo R, Kiyuna F, Nakamura K, Hata J, Wakisaka Y, Ago T, Kamouchi M, Kitazono T

    Cerebrovasc Dis   49 ( 6 )   601 - 608   2020.6

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  • An Embolic Stroke in a Patient With PROC p.Lys193del Reviewed

    Kana Ueki, Kuniyuki Nakamura, Yoshinobu Wakisaka, Shinichi Wada, Yoji Yoshikawa, Shinya Matsumoto, Taeko Hotta, Dongchong Kang, Takanari Kitazono, Tetsuro Ago

    Journal of Stroke and Cerebrovascular Diseases   29 ( 5 )   2020.5

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    DOI: 10.1016/j.jstrokecerebrovasdis.2019.104597

  • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes due to m.3243A > G mutation in a 76-year-old woman Reviewed

    Kana Ueki, Yoshinobu Wakisaka, Kuniyuki Nakamura, Yuji Shono, Shinichi Wada, Yoji Yoshikawa, Yuta Matsukuma, Takeshi Uchiumi, Dongchong Kang, Takanari Kitazono, Tetsuro Ago

    Journal of the Neurological Sciences   412   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jns.2020.116791

  • Attenuation of Angiotensin II–Induced Hypertension in BubR1 Low-Expression Mice Via Repression of Angiotensin II Receptor 1 Overexpression Reviewed

    8 ( 23 )   2019.12

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    Background: Angiotensin II (Ang II) can cause hypertension and tissue impairment via AGTR1 (Ang II receptor type 1), particularly in renal proximal tubule cells, and can cause DNA damage in renal cells via nicotinamide adenine dinucleotide phosphate oxidase. BubR1 (budding uninhibited by benzimidazole-related 1) is a multifaceted kinase that functions as a mitotic checkpoint. BubR1 expression can be induced by Ang II in smooth muscle cells in vitro, but the relationship between systemic BubR1 expression and the Ang II response is unclear. Methods and Results: Twenty 24-week-old male BubR1 low-expression mice (BubR1L/L mice) and age-matched BubR1+/+ mice were used in this study. We investigated how Ang II stimulation affects BubR1L/L mice. The elevated systolic blood pressure caused by Ang II stimulation in BubR1+/+ mice was significantly attenuated in BubR1L/L mice. Additionally, an attenuated level of Ang II–induced perivascular fibrosis was observed in the kidneys of BubR1L/L mice. Immunohistochemistry revealed that the overexpression of AGTR1 induced by Ang II stimulation was repressed in BubR1L/L mice. We evaluated AGTR1 and Nox-4 (nicotinamide adenine dinucleotide phosphate oxidase-4) levels to determine the role of BubR1 in the Ang II response. Results from in vitro assays of renal proximal tubule cells suggest that treatment with small interfering RNA targeting BubR1 suppressed Ang II-induced overexpression of AGTR1. Similarly, the upregulation in Nox4 and Jun N-terminal kinase induced by Ang II administration was repressed by treatment with small interfering RNA targeting BubR1. Conclusions: Ang II–induced hypertension is caused by AGTR1 overexpression in the kidneys via the upregulation of BubR1 and Nox4.

    DOI: 10.1161/JAHA.118.011911

  • Upregulation of annexin A1 in reactive astrocytes and its subtle induction in microglia at the boundaries of human brain infarcts Reviewed

    Masahiro Shijo, Hideomi Hamasaki, Hiroyuki Honda, Satoshi O. Suzuki, Masaki Tachibana, Tetsuro Ago, Takanari Kitazono, Koji Iihara, Toru Iwaki

    Journal of neuropathology and experimental neurology   78 ( 10 )   961 - 970   2019.10

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    DOI: 10.1093/jnen/nlz079

  • Quality Management Program of Stroke Rehabilitation Using Adherence to Guidelines A Nationwide Initiative in Japan Reviewed

    S. Miura, R. Miyata, S. Matsumoto, Takahiro Higashi, Yoshinobu Wakisaka, Tetsuro Ago, Takanari Kitazono, Koji Iihara, Megumi Shimodozono

    Journal of Stroke and Cerebrovascular Diseases   28 ( 9 )   2434 - 2441   2019.9

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    DOI: 10.1016/j.jstrokecerebrovasdis.2019.06.028

  • Arterial Spin Labeling Magnetic Resonance Imaging for Differentiating Acute Ischemic Stroke from Epileptic Disorders Reviewed

    Yuka Kanazawa, Shuji Arakawa, Takafumi Shimogawa, Noriko Hagiwara, Sei Haga, Takato Morioka, Hiroaki Ooboshi, Tetsuro Ago, Takanari Kitazono

    Journal of Stroke and Cerebrovascular Diseases   28 ( 6 )   1684 - 1690   2019.6

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    DOI: 10.1016/j.jstrokecerebrovasdis.2019.02.020

  • Poor glycemic control and posterior circulation ischemic stroke Reviewed

    Junya Kuroda, Ryu Matsuo, Yuko Yamaguchi, Noriko Sato, Masahiro Kamouchi, Jun Hata, Yoshinobu Wakisaka, Tetsuro Ago, Takanari Kitazono

    Neurology: Clinical Practice   9 ( 2 )   129 - 139   2019.4

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    DOI: 10.1212/CPJ.0000000000000608

  • Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis Reviewed

    Circulation   139 ( 2 )   295 - 298   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/CIRCULATIONAHA.118.038439

  • Usefulness of Transesophageal Echocardiography for Predicting Covert Paroxysmal Atrial Fibrillation in Patients with Embolic Stroke of Undetermined Source Reviewed

    Yuichiro Ohya, Masato Osaki, Shigeru Fujimoto, Juro Jinnouchi, Takayuki Matsuki, Satomi Mezuki, Masaya Kumamoto, Makoto Kanazawa, Naoki Tagawa, Tetsuro Ago, Takanari Kitazono, Shuji Arakawa

    Cerebrovascular diseases extra   9 ( 3 )   98 - 106   2019.1

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    DOI: 10.1159/000502713

  • Subacute Methotrexate Encephalopathy Mimicking Ischemic Stroke With Dynamic Changes on Magnetic Resonance Imaging Reviewed

    Kei Yamanaka, Takuya Okata, Yoshiki Sambongi, Ikumi Yamanaka, Kazuki Tanimoto, Tetsuro Ago, Takanari Kitazono, Jiro Kitayama

    Journal of Stroke and Cerebrovascular Diseases   27 ( 11 )   e233 - e235   2018.11

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    DOI: 10.1016/j.jstrokecerebrovasdis.2018.06.007

  • Safety of antithrombotic therapy for patients with acute ischemic stroke harboring unruptured intracranial aneurysm Reviewed

    Yuji Shono, Hiroshi Sugimori, Ryu Matsuo, Yoshihisa Fukushima, Yoshinobu Wakisaka, Junya Kuroda, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    International Journal of Stroke   13 ( 7 )   734 - 742   2018.10

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    DOI: 10.1177/1747493018765263

  • Association between stroke-like episodes and neuronal hyperexcitability in MELAS with m.3243A>G A case report Reviewed

    Shota Sakai, Masato Osaki, Masaoki Hidaka, Shunsuke Kimura, Yuichiro Ohya, Tetsuro Ago, Takanari Kitazono, Shuji Arakawa

    eNeurologicalSci   12   39 - 41   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ensci.2018.08.003

  • Association of Embolic Sources With Cause-Specific Functional Outcomes Among Adults With Cryptogenic Stroke Reviewed

    Fumi Kiyuna, Noriko Sato, Ryu Matsuo, Masahiro Kamouchi, Jun Hata, Yoshinobu Wakisaka, Junya Kuroda, Tetsuro Ago, Takanari Kitazono

    JAMA network open   1 ( 5 )   e182953   2018.9

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    DOI: 10.1001/jamanetworkopen.2018.2953

  • Paradoxical Brain Embolism in Elderly Subjects with Small Atrial Septal Defects Reviewed

    Taisuke Kitamura, Shuji Arakawa, Kei Murao, Takanari Kitazono, Tetsuro Ago

    Journal of Stroke and Cerebrovascular Diseases   27 ( 7 )   1987 - 1991   2018.7

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    DOI: 10.1016/j.jstrokecerebrovasdis.2018.02.053

  • Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community Reviewed

    Tomohiro Yubi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Seiji Gotoh, Naoki Hirabayashi, Yoshihiko Furuta, Tetsuro Ago, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Neurology: Clinical Practice   8 ( 3 )   223 - 231   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/CPJ.0000000000000464

  • NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells Reviewed International journal

    Sakai Y, Yamamori T, Yoshikawa Y, Bo T, Suzuki M, Yamamoto K, Ago T, Inanami O.

    Free Radic Res   52 ( 1 )   92 - 102   2018.1

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  • Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation A case report Reviewed

    Satomi Mezuki, Kenji Fukuda, Tomonaga Matsushita, Yoshihisa Fukushima, Ryu Matsuo, Yu ichi Goto, Takehiro Yasukawa, Takeshi Uchiumi, Dongchon Kang, Takanari Kitazono, Tetsuro Ago

    BMC neurology   17 ( 1 )   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12883-017-1001-4

  • Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke Reviewed International journal

    Matsuo R, Yamaguchi Y, Matsushita T, Hata J, Kiyuna F, Fukuda K, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Kamouchi M

    Stroke   48 ( 11 )   3049 - 3056   2017.11

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  • Left Atrial Size and Long-Term Risk of Recurrent Stroke After Acute Ischemic Stroke in Patients with Nonvalvular Atrial Fibrillation. Reviewed International journal

    J Am Heart Assoc   6 ( 8 )   e006402   2017.8

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  • Adverse Influence of Pre-Stroke Dementia on Short-Term Functional Outcomes in Patients with Acute Ischemic Stroke: The Fukuoka Stroke Registry Reviewed International journal

    Wakisaka Y, Matsuo R, Kuroda J, Ago T, Kitazono T, Kamouchi M

    Cerebrovascular diseases   43 ( 1-2 )   82 - 89   2017.6

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  • Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score. Reviewed International journal

    Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Sasaki M, Sakata K, Kobayashi S, Ogasawara K, Nakamura M, Hitomi J, Kita Y, Tanaka K, Iso H, Kitazono T, Kubo M, Tanaka H, Tsugane S, Kiyohara Y, Yamamoto M, Sobue K, Shimizu A.

    Stroke   48 ( 2 )   253 - 258   2017.2

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  • Short-Term Exposure to Fine Particulate Matter and Risk of Ischemic Stroke Reviewed International journal

    Matsuo R, Ago T, Kitazono T, Kamouchi M

    Stroke   47 ( 12 )   3032 - 3034   2016.12

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  • Influence of Statin Pretreatment on Initial Neurological Severity and Short-Term Functional Outcome in Acute Ischemic Stroke Patients: The Fukuoka Stroke Registry Reviewed International journal

    Ishikawa H, Wakisaka Y, Matsuo R, Ago T, Kitazono T

    Cerebrovasc diseases   42 ( 5-6 )   395 - 403   2016.5

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  • Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase Reviewed International journal

    Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, et al.

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   92   30 - 40   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.yjmcc.2016.01.020

  • Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia Reviewed International journal

    Tong X, Khandelwal AR, Qin Z, Wu X, Chen L, Ago T, et al.

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   89   185 - 194   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.yjmcc.2015.11.013

  • From Contractile Enhancement to Pathological Hypertrophy Angiotensin II-Induced Nox2-Mediated Reactive Oxygen Species Invited Reviewed International journal

    Ago T, Sadoshima J.

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   66 ( 3 )   273 - 277   2015.7

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    DOI: 10.1016/j.jacc.2015.05.058

  • Nox4 is a major source of superoxide production in human brain pericytes

    Kuroda J, Ago T

    J Vasc Res   2014.12

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  • Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines

    Chen L, Xiao J, Kuroda J, Ago T

    Biochim Biophys Acta   2014.12

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  • Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS).

    Kuwashiro T, Ago T

    Metabolism   2014.9

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  • Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke.

    Wakisaka Y, Ago T

    J Neurol Sci.   2014.5

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  • A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation.

    Shao D, Oka S, Liu T, Zhai P, Ago T

    Cell Metab   2014.2

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  • Impact of the 1425G/A Polymorphism of PRKCH on the Recurrence of Ischemic Stroke: Fukuoka Stroke Registry.

    Matsuo R, Ago T

    J Stroke Cerebrovasc Dis   2014.2

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  • Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke: Fukuoka Stroke Registry.

    Matsuo R, Kamouchi M, Ago T

    Geriatr Gerontol Int.   2013.12

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  • Predictive role of C reactive protein in stroke recurrence after cardioembolic stroke: the Fukuoka Stroke Registry.

    Kuwashiro T, Sugimori H, Ago T

    BMJ open   2013.11

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  • Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke: the Fukuoka Stroke Registry.

    Nakamura A, Ago T

    Stroke   2013.11

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  • The impact of predisposing factors on long-term outcome after stroke in diabetic patients: the Fukuoka Stroke Registry.

    Kuwashiro T, Sugimori H, Ago T

    Eur J Neurol.   2013.6

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  • RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke.

    Tokami H, Ago T

    Brain Research   2013.6

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  • Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study.

    Matsuo R, Ago T

    BMC Neurology   2013.4

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  • Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-inducible Factor-1α and Upregulation of Peroxisome Proliferator-activated Receptor-α. Reviewed International journal

    2013.4

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  • Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Reviewed International journal

    Matsushima S, Kuroda J, Ago T

    Circulation Research   2013.2

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  • Risk factors predisposing to stroke recurrence within one year of non-cardioembolic stroke onset: the Fukuoka Stroke Registry Reviewed International journal

    Kuwashiro T, Sugimori H, Ago T, Kamouchi M, Kitazono T; FSR Investigators

    Cerebrovasc Dis   33 ( 2 )   2012.2

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  • The factors associated with a functional outcome after ischemic stroke in diabetic patients: the Fukuoka Stroke Registry Reviewed International journal

    Kuwashiro T, Kamouchi M, Ago T, Hata J, Sugimori H, Kitazono T

    J Neurol Sci   313 ( 1-2 )   2012.2

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  • Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; FSR Investigators

    Stroke   42 ( 10 )   2011.10

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  • Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7. International journal

    Yang Y, Ago T, Zhai P, Abdellatif M, Sadoshima J.

    Circ Res   2011.2

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  • Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload. International journal

    Ago T, Yang Y, Zhai P, Sadoshima J.

    J Cardiovasc Transl Res.   2010.8

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  • Midkine gene transfer protects against focal brain ischemia and augments neurogenesis. Reviewed International journal

    Ishikawa E, Ooboshi H, Kumai Y, Takada J, Nakamura K, Ago T, Sugimori H, Kamouchi M, Kitazono T, Ibayashi S, Iida M.

    J Neurol Sci.   285   2009.5

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  • Elucidation of thioredoxin target protein networks in mouse. International journal

    Fu C, Wu C, Liu T, Ago T, Zhai P, Sadoshima J, Li H.

    8   2009.5

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  • Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes. International journal

    Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Shono Y, Hagiwara N, Ago T, Ooboshi H, Ibayashi S, Iida M.

    Microvasc Res.   77   2009.5

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  • Thioredoxin1 Upregulates Mitochondrial Proteins Related to Oxidative Phosphorylation and TCA Cycle in the Heart. Reviewed International journal

    Ago T, Yeh I, Yamamoto M, Schinke-Braun M, Brown JA, Tian B, Sadoshima J.

    Antioxid Redox Signal   2006.9

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  • The PX domain as a novel phosphoinositide-binding module. Reviewed International journal

    Ago T, Takeya R, Hiroaki H, Kuribayashi F, Ito T, Kohda D, Sumimoto H.

    Biochem Biophys Res Commun   287 ( 3 )   733 - 738   2001.9

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    DOI: 10.1006/bbrc.2001.5629

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Books

  • 必携脳卒中ハンドブック(改訂第4版)

    吉野文隆, 吾郷哲朗( Role: Joint author)

    診断と治療社  2024.3 

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    Language:Japanese   Book type:Scholarly book

  • 高血圧性脳出血に対する降圧は, いつ, どれくらいまで, どのように行うべきか?

    @大屋祐一郎,@吾郷哲朗( Role: Joint author)

    中外医学社  2023.3 

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    Language:Japanese   Book type:Scholarly book

  • 血管への感染と血液脳関門の破綻.COVID-19 神経ハンドブック ―急性期,後遺症からワクチン副反応まで―

    @日高壮意, @吾郷哲朗( Role: Joint author)

    中外医学社  2022.5 

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    Language:Japanese   Book type:Scholarly book

  • Annual Review 神経2020 「脳梗塞のバイオマーカー」

    吾郷哲朗( Role: Joint author)

    中外医学社  2020.4 

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    Language:Japanese   Book type:Scholarly book

  • マスター脳卒中学 「脳卒中と遺伝子」

    吾郷哲朗( Role: Joint author)

    西村書店  2019.7 

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    Language:Japanese   Book type:Scholarly book

  • 脳卒中病態学のススメ 血液脳関門とneurovascular unit

    吾郷哲朗( Role: Joint author)

    南山堂  2018.3 

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    Language:Japanese   Book type:Scholarly book

  • 脳神経外科診療プラクティス6

    吾郷 哲朗( Role: Joint author)

    文光堂  2015.9 

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    Language:Japanese   Book type:Scholarly book

  • 脳神経外科診療プラクティス5

    吾郷 哲朗( Role: Joint author)

    文光堂  2015.4 

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  • 脳梗塞診療読本

    豊田一則, 吾郷 哲朗( Role: Joint author)

    2014.3 

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    Language:Japanese   Book type:General book, introductory book for general audience

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Presentations

  • The Fukuoka Stroke Registry. Invited International conference

    Ago T, Matsuo R, Kamouchi M, Kitazono T.

    International Conference STROKE UPDATE 2023 & 11th Japan-Korea Joint Stroke Conference.  2023.11 

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    Event date: 2023.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Korea, Republic of  

  • 活性酸素産生酵素NOXファミリーNADPHオキシダーゼ〜発見から半世紀、現状、そして未来へ〜Nox4遺伝子修飾による動物疾患モデルにおける表現型変化. Invited

    吾郷哲朗

    第96回日本生化学会  2023.11 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Roles of Pericyte in brain health and cerebrovascular diseases (Pericytes -Functional diversity and commonality in health and disease) Invited

    Tetsuro Ago

    2023.3 

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    Event date: 2023.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 意外と知らない脳梗塞の基本病態〜基礎研究から学ぶ. Invited

    吾郷哲朗

    第5回 日本神経学会特別教育研修会:脳卒中コース  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎   Country:Japan  

  • Reciprocal interaction between pericytes and macrophage in post-stroke tissue repair and functional recovery. “High Impact Articles in Post-stroke Outcomes 2020 International conference

    2021.3 

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    Event date: 2021.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • 脳虚血病態におけるペリサイトの役割 Invited

    吾郷 哲朗

    第56回日本神経学会学術大会  2015.5 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:新潟   Country:Japan  

  • Role of pericytes in neuroprotection during brain ischemia Invited International conference

    Ago T

    BRI International Symposium 2012  2012.3 

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    Event date: 2012.3

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Neuroprotective Roles of Brain Pericytes through PDGFRβ-Akt Signaling in Ischemic Stroke International conference

    2012.2 

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    Event date: 2012.2

    Presentation type:Oral presentation (general)  

    Venue:New Orleans   Country:United States  

  • Role of NADPH oxidase 4 in Brain Endothelial Cells after Ischemic Stroke International conference

    Arimura K, Ago T

    International Stroke Conference 2012  2012.2 

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    Event date: 2012.2

    Presentation type:Oral presentation (general)  

    Country:United States  

  • Roles of PDGF–PDGF-Rβ Signaling in Brain Pericytes in Ischemic Stroke International conference

    2011.2 

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    Event date: 2011.2

    Venue:LA   Country:United States  

  • Nox4 is a major source of ROS in the failing heart Invited International conference

    Ago T

    Gordon Research Conference on Nox family NADPH oxidases 2010  2010.6 

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    Event date: 2010.6

    Presentation type:Oral presentation (general)  

    Country:Switzerland  

    Gordon Research Conference on Nox family NADPH oxidases 2010

    Other Link: http://www.grc.org/programs.aspx?year=2010&program=nox

  • Redox-mediated regulation of HDAC4, a class II HDAC, by Thioredoxin1 through interaction with DnaJb5, a Heat Shock Protein 40. International conference

    Ago T, Liu T, Li H, Molkentin J, Sadoshima J

    AHA Scientific Session 2007  2007.11 

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    Event date: 2007.11

    Country:United States  

    Other Link: http://www.med.kyushu-u.ac.jp/stroke/PDF/Katz%20issue.pdf

  • 活性酸素種産生酵素Nox4による内皮・周皮細胞の分子制御とその意義 Invited International conference

    吾郷 哲朗

    脳心血管抗加齢研究会  2014.12 

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    Venue:大阪   Country:Japan  

  • 既存分類を用いたFukuoka Stroke Registryにおける病型頻度. Invited

    吾郷哲朗, 松尾龍, 佐藤倫子, 喜友名扶弥, 脇坂義信,鴨打正浩, 北園孝成

    第49回日本脳卒中学会学術総会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • Macrophage infiltration is required for pericyte recruitment in poststroke tissue repair. International conference

    Hidaka Masaoki, Nakamura Kuniyuki, Yoshino Fumitaka, Takashima Masamitsu, Kiyohara Takuya, Wakisaka Yoshinobu, Kitazono Takanari, Ago Tetsuro

    Neuroscience 2023  2023.11 

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    Event date: 2023.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • NOX4 plays crucial role in angiogenic responses and in recruitment of pericytes and macrophages in poststroke tissue repair. International conference

    Nakamura Kuniyuki, Hidaka Masaoki, Yoshino Fumitaka, Takashima Masamitsu, Kiyohara Takuya, Wakisaka Yoshinobu, Kitazono Takanari, Ago Tetsuro

    Neuroscience 2023  2023.11 

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    Event date: 2023.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 人生100年時代!健康寿命延伸と急性期脳梗塞における抗凝固療法. Invited

    吾郷哲朗

    第82回日本脳神経外科学会学術総会  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:横浜   Country:Japan  

  • 「どうすれば脳梗塞後機能回復を向上させることができるか?」 Invited

    吾郷哲朗, 中村晋之, 清原卓也, 脇坂義信, 北園孝成.

    第48回日本脳卒中学会学術総会. 2023.3.16 横浜(シンポジウム)  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 「脳虚血におけるペリサイトの役割」 Invited

    吾郷哲朗

    第65回日本脳循環代謝学術学会  2022.10 

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    Event date: 2022.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:山梨   Country:Japan  

  • Polyvascular Atherosclerotic Disease-脳梗塞におけるトピックス- Invited

    吾郷哲朗

    第54回日本動脈硬化学会総会学術集会  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:久留米   Country:Japan  

  • 超高齢化社会における脳卒中発症予防のための抗血栓療法. Invited

    吾郷哲朗

    第47回日本脳卒中学会学術集会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 人生100年時代の脳卒中発症予防–健康寿命の延伸を目指して–. Invited

    吾郷哲朗

    第37回日本脳神経血管内治療学会. 2021.11.26 福岡  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 低酸素と自律神経」脳虚血病態における細胞間連関と臓器連関- 新たな治療標的は何か?-. Invited

    吾郷哲朗

    第74回日本自律神経学会総会.  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 「脳卒中ハイリスク患者への血圧管理と診療のキモ:目から鱗の90分」脳血管障害ハイリスク患者再発予防のキモ. Invited

    吾郷哲朗

    第43回日本高血圧学会総会  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • 脳卒中発症予防のためのリスク管理. Invited

    吾郷哲朗

    第65回日本内科学会信越支部主催 生涯教育講演会  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:新潟   Country:Japan  

  • てんかんと脳血管障害 Invited

    吾郷哲朗

    第46回日本脳卒中学会学術集会.  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 「頭蓋内狭窄症治療の今」 頭蓋内アテローム性動脈硬化症の自然経過と内科治療 Invited

    吾郷哲朗

    第45回日本脳卒中学会学術集会.  2020.8 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • ペリサイトの立場からみた認知症発症機構:アルツハイマー型と脳血管性のオーバーラップ. Invited

    吾郷哲朗

    第52回日本動脈硬化学会総会学術集会  2020.7 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • 脳梗塞のバイオマーカー Invited

    吾郷哲朗

    第37回日本神経治療学会学術集会  2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 高齢者脳疾患発症予防の立場から生活習慣病の管理を考える. Invited

    吾郷哲朗

    第19回日本NO学会学術集会  2019.6 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:久留米   Country:Japan  

  • 脳卒中患者における血圧管理の重要性. Invited

    吾郷哲朗, 北園孝成

    第44回日本脳卒中学会学術集会.  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 脳虚血の治療標的としてのペリサイトの重要性. Invited

    吾郷哲朗

    第44回日本脳卒中学会学術集会.  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 「脳循環代謝の基礎 脳虚血の病態生理」 Invited

    吾郷哲朗

    第1回 日本神経学会特別教育研修会:脳卒中コース  2018.7 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • 脳血管障害における脂質異常症管理の意義. Invited

    吾郷哲朗

    第5回日本心血管脳卒中学会学術集会.  2018.6 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • ESUSの定義 Invited

    吾郷哲朗

    第5回日本心血管脳卒中学会学術集会  2018.6 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 脳虚血病態におけるペリサイトの多様な役割 Invited

    吾郷哲朗

    第59回日本神経学会学術大会  2018.5 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:札幌   Country:Japan  

  • 「Oxidative stress and disease」Nox4 promotes neural stem/precursor cell proliferation and neurogenesis in the hippocampus. Invited

    第95回日本生理学会大会  2018.3 

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    Event date: 2018.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:高松   Country:Japan  

  • Redefinition of vascular dementia. Pericyte in health and cerebrovascular diseases. Invited

    Ago T

    ConBio 2017  2017.12 

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    Event date: 2017.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 「Brain Science を探る:血液脳関門を中心に」脳梗塞病態における周皮細胞の多様な作用. Invited

    吾郷哲朗

    第60回日本脳循環代謝学術学会  2017.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • RA系阻害薬の「臓器保護作用」を再検証する Beyond BP lowering effectsは是か非か?」Stroke and Hypertension: Benefits of the RA system regulation in preventing development and progression of Stroke? Invited

    吾郷哲朗

    第40回日本高血圧学会総会  2017.10 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛   Country:Japan  

  • 「未破裂脳動脈瘤と抗血栓療法,危険因子」急性期脳梗塞患者における未破裂脳動脈瘤と抗血栓療法の実態. Invited

    吾郷哲朗

    第26回日本脳ドック学会総会.  2017.6 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 「心血管病における脂質異常管理」脳梗塞発症予防および神経保護における脂質管理の意義と可能性. Invited

    吾郷哲朗

    第4回日本心血管脳卒中学会学術集会  2017.6 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • ”The diverse functions and phenotypes of pericyte – from bench to bedside” Role and significance of pericyte in cerebrovascular diseases. Invited

    第94回日本生理学会大会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松   Country:Japan  

  • 「基礎と臨床を渡す脳血管障害の新研究」脳梗塞後の組織修復における再灌流治療の有用性に関する基礎的研究. Invited

    吾郷哲朗

    第42回日本脳卒中学会学術集会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Neuroprotective Role of Brain Pericytes through PDGFRb after Ischemic Stroke Invited International conference

    Tetsuro Ago

    Transpasific Workshop on Stroke  2012.10 

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    Event date: 2012.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Clinical Characteristics Of Acute Brain Infarction During Anti-coagulation Therapy With Warfarin -the Fukuoka Stroke Registry (FSR)- International conference

    Nakamura A, Ago T, et al

    International Stroke Conference 2011  2011.2 

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    Event date: 2011.2

    Country:United States  

  • Significance of VEGF in Ischemic Stroke - Research for Biomarkers in Ischemic Stroke (REBIOS) - International conference

    Matsuo R, Ago T, et al.

    International Stroke Conference 2011  2011.2 

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    Event date: 2011.2

    Country:United States  

  • 脳梗塞におけるバイオマーカー探索(REBIOS):網羅的なサイトカインの動態解析

    吾郷 哲朗,ほか

    第51回日本神経学会総会  2010.5 

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    Event date: 2010.5

    Country:Japan  

  • 脳梗塞バイオマーカーとしてのG-CSF -Research for Biomarkers in Ischemic Stroke(REBIOS)-

    吾郷哲朗,ほか

    2010.4 

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    Event date: 2010.4

    Venue:岩手   Country:Japan  

  • 脳梗塞におけるバイオマーカー探索・解析に関する研究(REBIOS):脳梗塞発症後のサイトカイン動態

    吾郷哲朗,鴨打正浩,牧原典子,緒方利安,湧川佳幸,矢坂正弘,岡田靖,秦 淳,粟野秀人,磯村哲,渡部和加子,鈴木一夫,北園孝成,清原裕,飯田三雄

    日本脳循環代謝学会  2009.11 

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    Event date: 2009.11 - 2010.11

    Venue:大阪   Country:Japan  

  • 穿通枝脳梗塞の臨床的背景-Fukuoka Stroke Registry (FSR)-

    吾郷哲朗、杉森宏、鴨打正浩、大星博明、北園孝成、飯田三雄

    第50回日本神経学会総会  2009.5 

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    Event date: 2009.5

    Venue:仙台   Country:Japan  

  • ワルファリン内服患者の脳卒中発症状況に関する研究-Fukuoka Stroke Registry (FSR)-

    吾郷哲朗、杉森宏、桑城貴弘、吉村壮平、後藤聖司、鴨打正浩、大星博明、井林雪郎、北園孝成、飯田三雄

    第34回日本脳卒中学会総会  2009.4 

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    Event date: 2009.3

    Venue:島根   Country:Japan  

  • 脳卒中診療に役立つ分子マーカー Invited

    吾郷 哲朗

    第40回日本脳卒中学会総会  2015.3 

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    Language:Japanese  

    Venue:広島   Country:Japan  

  • Roles of pericytes during brain ischemia Invited

    2012.4 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • Pathophysiological roles of ROS derived from the Nox family proteins in cerebral blood vessels Invited

    2012.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 臨床現場のアンメットニーズー脳血管障害ー Invited

    吾郷 哲朗

    第31回日本DDS学会学術集会  2014.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Roles of pericyte Nox4 in acute brain ischemia International conference

    Nishimura A, Ago T

    Sfn  2014.11 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • 脳虚血により微小血管細胞に発現誘導されるNox4の意義 Invited

    吾郷 哲朗

    第26回脳循環代謝学会  2014.11 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:岡山   Country:Japan  

  • 心・脳血管病から見える活性酸素種産生酵素Nox4の功罪 Invited

    吾郷 哲朗

    第31回臨床フリーラジカル会議  2014.12 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

▼display all

MISC

  • Pericyte-Mediated Molecular Mechanisms Underlying Tissue Repair and Functional Recovery after Ischemic Stroke. Reviewed

    Nakamura K, Ago T

    J Atheroscler Thromb   2023.9

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: doi.org/10.5551/jat.RV22007

  • 「発展する脳卒中診療の最前線」Neurovascular unit - 脳梗塞発症から機能回復まで.

    吾郷哲朗

    医学のあゆみ   2022.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳血管障害のリスクコントロール

    吾郷哲朗

    診断と治療   2021.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • ペリサイトは脳機能にとってなぜ重要なのか? Reviewed

    吾郷哲朗

    臨床神経   2019.11

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  • ペリサイトを標的とした脳血管障害治療の可能性.

    吾郷哲朗

    日本臨床   2019.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • The neurovascular unit in health and ischemic stroke

    2016.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • なぜ周皮細胞か?—脳梗塞病対における周皮細胞の挙動とその重要性—

    吾郷 哲朗

    脳循環代謝   2016.2

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 虚血性脳卒中治療の基礎的研究の進歩

    吾郷 哲朗

    動脈硬化予防   2016.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳梗塞のバイオマーカー

    吾郷 哲朗

    2015.12

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  • 血液脳関門/Neurovascular unitの 形成・維持における脳ペリサイトの重要性

    吾郷 哲朗

    2013.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • The possible roles of brain pericytes in brain ischemia and stroke

    Kamouchi M, Ago T, Kuroda J, Kitazono T.

    Cell Mol Neurobiol   2012.3

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Pathophysiological Roles of NADPH Oxidase/Nox Family Proteins in the Vascular System – Review and Perspective –

    2011.7

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    Other Link: http://www.jstage.jst.go.jp/article/circj/75/8/75_1791/_article

  • Brain pericytes: emerging concepts and functional roles in brain homeostasis.

    Kamouchi M, Ago T, Kitazono T.

    Cell Mol Neurobiol.   2011.3

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  • The NADPH oxidase Nox4 and aging in the heart

    Ago T, Matsushima S, Kuroda J, Zablocki D, Kitazono T, Sadoshima J.

    Aging   2010.12

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  • Thioredoxin1 as a negative regulator of cardiac hypertrophy.

    Ago T, Sadoshima J.

    2007.6

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  • 脳梗塞と血液検査

    立花 正輝, 吾郷 哲朗

    日本臨床   1900

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  • 脳微小循環とneurovascular unit. 内皮細胞・周皮細胞の立場から

    中村 晋之, 吾郷 哲朗

    日本臨床   1900

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  • 神経内科専門医試験問題 解答と解説

    吾郷哲朗

    神経内科専門医試験問題 解答と解説 第2集   2024.2

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  • 脳静脈洞血栓症.

    横井美央, 吾郷哲朗

    日本臨床   2024.2

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  • (症例に学ぶ臨床検査データの診かた–専門医はこう読む–) 二次性高血圧.

    @井上美奈子,@吾郷哲朗

    臨床と研究   2023.5

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  • 単なる壁細胞ではない –脳機能遂行の鍵を握るペリサイト–

    @日高壮意, @吾郷哲朗.

    2022.12

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  • 脳虚血病態におけるペリサイト機能の重要性

    吾郷哲朗

    日本臨牀   2022.6

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  • 血管への感染と血液脳関門の破綻.

    日高壮意, 吾郷哲朗

    COVID-19 神経ハンドブック ―急性期,後遺症からワクチン副反応まで― 中外医薬社   2022.5

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  • (特集Ⅱ/脳卒中と社会背景) 気候・大気汚染と脳卒中

    @松尾龍, @吾郷哲朗

    脳神経内科   2022.4

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  • Can calcium channel blockers prevent ischemic stroke in nonvalvular atrial fibrillation patients?—the optimal choice of antihypertensive drug for subtype-specific stroke prevention. Reviewed

    2022.3

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  • 脳微小循環とNeurovascular Unit

    吾郷哲朗

    日本臨牀   2022.1

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  • 急性期脳出血の血圧管理

    吾郷哲朗

    臨床と研究   2021.8

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  • 脳血管障害の診断

    植木香奈, 松尾龍, 吾郷哲朗

    臨床透析   2020.6

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  • 高血圧と脳血管障害

    吾郷哲朗

    臨床と研究   2020.1

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  • 合併症の管理はどう変わったか−脳血管障害−血清尿酸値と脳卒中

    中村晋之, 吾郷哲朗, 北園孝成

    診断と治療   2019.12

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  • てんかんはなぜ高齢者・脳卒中患者に多いのか?その発生機序を考察する.

    吾郷哲朗

    臨床と研究   2019.6

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  • 「抗血小板薬の特性を理解する」アスピリンの適応と使用法.

    吾郷哲朗

    2019.2

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  • 脳血管障害外来患者の診療に役立つ高血圧症の管理.

    吾郷哲朗

    脳神経外科   2019.1

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  • 脳血管障害における先制医療

    植木香奈,吾郷哲朗,北園孝成.

    臨床検査   2019.1

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  • 脳卒中と高血圧:脳卒中の発症・進展におけるRA系制御の有益性

    和田晋一, 吾郷哲朗

    血圧   2018.11

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 外来で必要な脳卒中診療のエッセンス,脳卒中慢性期のリスク管理「糖尿病」

    吾郷哲朗

    臨床と研究   2018.10

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳虚血病態におけるペリサイトの役割.

    吾郷哲朗

    分子脳血管病   2018.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • NADPH Oxidase-Related Pathophysiology in Experimental Models of Stroke

    Yao H, Ago T, Kitazono T, Nabika T

    Int J Mol Sci   2017.10

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 「意識障害患者を診る」脳血管障害

    吾郷哲朗

    臨床と研究   2017.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Wallenberg症候群とOpalski症候群

    入江ひろみ,北山次郎,吾郷哲朗

    2017.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 活性酸素と動脈硬化

    吉川容司,吾郷哲朗

    日本臨牀   2017.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • The role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy.

    Oka S, Ago T, Kitazono T, Zablocki D, Sadoshima J.

    J Mol Med   2009.8

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Worsening of Ipsilateral Hemiparesis After Recurrent Stroke.

    Ago T

    Journal Watch Neurology   2007.9

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Thioredoxin and ventricular remodeling.

    Ago T, Sadoshima J.

    J Mol Cell Cardiol   2006.11

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • GDF15, a cardioprotective TGF-beta superfamily protein.

    Ago T, Sadoshima J.

    Circ Res   2006.2

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Industrial property rights

Patent   Number of applications: 3   Number of registrations: 3
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • International Society of Cerebral Blood Flow & Metabolism

  • American Heart Association, Stroke council & Basic CardioVascular Science council

  • 日本老年学会

  • 日本神経学会

  • 日本再生医療学会

  • 日本認知症学会

  • Cardiovascular Stroke Society of Japan

  • 日本脳循環代謝学会

  • 日本脳卒中学会

  • 日本内科学会

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Committee Memberships

  • 日本神経学会   学術大会学術委員   Domestic

    2021.6 - 2023.5   

  • The Mt. Fuji Workshop on CVD   Organizer   Domestic

    2019.8 - Present   

  • Organizer   Domestic

    2017.11 - 2021.5   

  • 日本脳循環代謝学会   国際委員, 基礎研究推進委員   Domestic

    2017.11 - 2021.5   

  • Councilor   Domestic

    2017.6 - Present   

  • 日本心血管脳卒中学会   学術評議員   Domestic

    2017.6 - Present   

  • International Society of Cerebral Blood Flow and Metabolism   Membership   Foreign country

    2016.4 - Present   

  • Councilor   Domestic

    2015.4 - 2021.5   

  • 日本脳卒中学会   代議員   Domestic

    2015.4 - 2021.5   

  • Stroke (AHA)   Steering committee member   Foreign country

    2012.7 - 2021.5   

  • Stroke (AHA)   Assistant editor   Foreign country

    2012.7 - 2021.5   

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Academic Activities

  • プログラム委員, 座長, 講演

    第49回日本脳卒中学会学術集会  ( 横浜 ) 2024.3

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    Type:Competition, symposium, etc. 

  • 講演

    第96回日本生化学会大会  ( 福岡 ) 2023.10 - 2023.11

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    Type:Competition, symposium, etc. 

  • 座長

    第66回日本脳循環代謝学会総会  ( 福岡 ) 2023.10

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    Type:Competition, symposium, etc. 

  • 座長

    第41回 The Mt. Fuji Workshop on CVD  ( 京都 ) 2023.8

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    Type:Competition, symposium, etc. 

  • 年次学術委員, 査読委員, 座長

    第64回日本神経学会学術大会  ( 千葉 ) 2023.5 - 2022.6

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    Type:Competition, symposium, etc. 

  • プログラム委員, 座長, 講演

    第48回日本脳卒中学会学術集会  ( 横浜 ) 2023.3

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    Type:Competition, symposium, etc. 

  • 講演

    日本生理学会 第100回記念大会  ( 京都 ) 2023.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:26

    Proceedings of International Conference Number of peer-reviewed papers:30

    Proceedings of domestic conference Number of peer-reviewed papers:46

  • 座長

    第65回日本脳循環代謝学会総会  ( 山梨 ) 2022.10

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    Type:Competition, symposium, etc. 

  • 座長

    第40回 The Mt. Fuji Workshop on CVD  ( 東京 ) 2022.8

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    Type:Competition, symposium, etc. 

  • 年次学術委員, 査読委員, 座長

    第63回日本神経学会学術大会  ( 東京 ) 2022.5

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    Type:Competition, symposium, etc. 

  • 講演

    第47回日本脳卒中学会学術集会  ( 大阪 ) 2022.3

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    Type:Competition, symposium, etc. 

  • 座長

    第32回日本老年医学会九州地方会  ( 大分 ) 2022.2

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    Type:Competition, symposium, etc. 

  • 座長

    第47回日本脳卒中学会学術集会  ( 大阪 ) 2022.1

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:23

    Proceedings of International Conference Number of peer-reviewed papers:30

    Proceedings of domestic conference Number of peer-reviewed papers:60

  • 講演

    第37回日本脳神経血管内治療学会  ( 福岡 ) 2021.11

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    Type:Competition, symposium, etc. 

  • シンポジスト

    第74回日本自律神経学会総会  ( 東京 ) 2021.10

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    Type:Competition, symposium, etc. 

  • シンポジスト

    第43回日本高血圧学会総会  ( 沖縄 ) 2021.10

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    Type:Competition, symposium, etc. 

  • 講演

    第65回日本内科学会信越支部主催生涯教育講演会  ( 新潟 ) 2021.10

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    Type:Competition, symposium, etc. 

  • 査読委員

    第62回日本神経学会学術大会  ( 京都 ) 2021.5

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    Type:Competition, symposium, etc. 

  • シンポジスト International contribution

    2021.3

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    Type:Competition, symposium, etc. 

  • 座長

    第46回日本脳卒中学会学術集会  ( 福岡 ) 2021.3

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    Type:Competition, symposium, etc. 

  • シンポジスト

    第46回日本脳卒中学会学術集会  ( 福岡 ) 2021.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

    Proceedings of International Conference Number of peer-reviewed papers:20

    Proceedings of domestic conference Number of peer-reviewed papers:56

  • Stroke (AHA) International contribution

    2020.7 - Present

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    Type:Academic society, research group, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:29

    Proceedings of domestic conference Number of peer-reviewed papers:48

  • シンポジスト, 座長 International contribution

    2019.11

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    Type:Competition, symposium, etc. 

  • 座長

    第62回日本脳循環代謝学会総会  ( 仙台 ) 2019.10

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    Type:Competition, symposium, etc. 

  • 座長

    第44回日本脳卒中学会学術集会  ( 横浜 ) 2019.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • シンポジスト

    第95回日本生理学会大会  ( 高松 ) 2018.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第29回日本老年医学会九州地方会  2018.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:24

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2017.12 - 2020.11

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    Type:Scientific advice/Review 

  • シンポジスト

    第94回日本生理学会大会  ( 浜松 ) 2017.3

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    Type:Competition, symposium, etc. 

  • シンポジスト

    第42回日本脳卒中学会学術集会  ( 大阪 ) 2017.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:24

    Proceedings of International Conference Number of peer-reviewed papers:20

  • 特別公演

    第20回眼創傷治癒研究会  ( 福岡 ) 2016.8

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    Type:Competition, symposium, etc. 

  • シンポジスト

    ( 金沢 ) 2016.8

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    Type:Competition, symposium, etc. 

  • シンポジスト

    ( 神戸 ) 2015.12

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    Type:Competition, symposium, etc. 

  • シンポジウム

    第27回日本脳循環代謝学会総会  ( 富山 ) 2015.10

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    Type:Competition, symposium, etc. 

  • シンポジスト

    第74回日本脳神経外科学会学術総会  ( 札幌 ) 2015.10

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    Type:Competition, symposium, etc. 

  • 教育講演

    ( 福岡 ) 2015.7

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    Type:Competition, symposium, etc. 

  • シンポジスト

    第31回日本DDS学会学術集会  ( 東京 ) 2015.7

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    Type:Competition, symposium, etc. 

  • 教育講演

    第56回日本神経学会学術大会  ( 新潟,日本 ) 2015.5

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    Type:Competition, symposium, etc. 

  • Journal of Stroke and Cerebrovascular Disease International contribution

    Role(s): Peer review

    2015.4 - 2020.3

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    Type:Academic society, research group, etc. 

  • 教育講演

    日本脳卒中学会総会2015  ( 広島,日本 ) 2015.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第25回日本老年学会九州地方会  ( 福岡 ) 2015.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第308回日本内科学会九州地方会  ( 福岡 ) 2015.1

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    Type:Competition, symposium, etc. 

  • シンポジスト

    脳心血管抗加齢研究会  ( 大阪,日本 ) 2014.12

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    Type:Competition, symposium, etc. 

  • シンポジスト

    第26回日本脳循環代謝学会総会  ( 岡山,日本 ) 2014.11

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    Type:Competition, symposium, etc. 

  • シンポジスト

    第24回脳血管シンポジウム  ( 大阪,日本 ) 2014.9

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    Type:Competition, symposium, etc. 

  • シンポジスト

    第34回脳神経外科コングレス総会  ( 大阪,日本 ) 2014.5

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    Type:Competition, symposium, etc. 

  • シンポジスト

    日本脳卒中学会総会2014  ( 大阪,日本 ) 2014.3

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    Type:Competition, symposium, etc. 

    Number of participants:100

  • 座長(Chairmanship)

    第39回日本脳卒中学会総会 Stroke2014  ( 大阪 ) 2014.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第304回日本内科学会九州地方会  ( 福岡 ) 2014.1

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第25回日本脳循環代謝学会総会  ( 札幌 ) 2013.11 - 2014.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第54回日本神経学会学術大会  ( 東京 ) 2013.5 - 2013.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第23回日本老年医学会九州地方会  2013.3

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    Type:Competition, symposium, etc. 

  • シンポジスト International contribution

    第44回日本動脈硬化学会総会: 脳動脈硬化から脳虚血へ~その分子メカニズムを探る~  ( 福岡,日本 ) 2012.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第37回日本脳卒中学会総会 Stroke2012  ( 福岡 ) 2012.4

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    Type:Competition, symposium, etc. 

  • シンポジスト

    日本脳卒中学会総会2012(福岡) 脳卒中最先端の基礎研究から  ( 福岡,日本 ) 2012.4

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    Type:Competition, symposium, etc. 

    Number of participants:100

  • シンポジスト International contribution

    第2回新潟大学脳研究所共同研究拠点国際シンポジウム  ( 新潟,日本 ) 2012.3

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    Type:Competition, symposium, etc. 

    Number of participants:80

  • American Journal of Physiology - Heart and Circulatory Physiology International contribution

    Role(s): Peer review

    2011.1 - 2019.12

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    Type:Academic society, research group, etc. 

  • 座長(Chairmanship)

    第21回日本脳循環代謝学会総会  ( 大阪 ) 2009.11

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    Type:Competition, symposium, etc. 

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Research Projects

  • 脳梗塞機能回復治療への挑戦 - ペリサイトをいかに再動員させるか?

    Grant number:24K02556  2024 - 2027

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 炎症惹起シグナルIL-33/ST2による脳梗塞内ペリサイト動員と組織修復の分子機構

    2023

    先進医薬研究振興財団 循環医学分野 一般研究者助成

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    Authorship:Principal investigator  Grant type:Contract research

  • マクロファージ機能制御による脳梗塞後組織修復および機能回復促進治療の確立

    2023

    ベーリンガーインゲルハイム・ライフサイエンス・リサーチサポート

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    Authorship:Principal investigator  Grant type:Contract research

  • 脳卒中精密医療の基盤構築に関する研究

    Grant number:21K19648  2021 - 2023

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 医師主導治験AMCAD試験の体制整備事業

    2021 - 2023

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 脳梗塞巣におけるペリサイトを介した創傷治癒と内因性機能回復機構の解明

    Grant number:20H03791  2020 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 脳虚血病態におけるペリサイトの細胞死にフェロトーシスは関与するか?

    Grant number:20K09373  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 脳梗塞組織修復ならびに組織修復による神経機能回復誘導に関する分子細胞機構の解明

    2019

    ブリストル・マイヤーズスクイブ研究助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 脳血管障害におけるSGLT2の役割

    2018.4 - 2022.3

    受託研究

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Other funds from industry-academia collaboration

  • 脳梗塞後の修復応答により誘導される梗塞周囲再髄鞘化および機能回復の分子細胞機構についての研究

    2018

    先進医薬研究振興財団 循環医学分野 一般研究者助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 喫煙が虚血性脳卒中の発症と転帰に及ぼす影響についての基礎ならびに臨床疫学研究

    2017 - 2021

    喫煙科学財団 特定研究

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    Authorship:Principal investigator  Grant type:Contract research

  • ペリサイト機能に基づく脳梗塞後組織修復と神経機能回復誘導メカニズムの解明

    Grant number:16H05439  2016 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 認知機能障害が脳卒中再発に与える影響およびその早期対策法についての研究

    Grant number:15K09354  2015 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • Can rivaroxaban, an inhibitor of Xa, attenuate pericyte-mediated inflammation and fibrosis after ischemic stroke?

    2015 - 2016

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    Authorship:Principal investigator  Grant type:Contract research

  • 内皮細胞におけるNox4による低酸素応答増強メカニズムの解明

    Grant number:26461145  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • pH強調MR画像の開発と急性期脳梗塞における組織予後推定への応用

    Grant number:26293278  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • アルツハイマー病・脳血管性認知症に対する脳機能改善薬の開発

    2014 - 2016

    研究開発施設共用等促進費補助金(橋渡し研究加速ネットワークプログラム)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 脳梗塞後に生じる線維化応答の是非に関する検討

    2014 - 2015

    先進医薬研究振興財団 循環医学分野

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    Authorship:Principal investigator  Grant type:Contract research

  • 脳梗塞病態における酸化ストレスによる血液凝固反応亢進機構の 解明

    2012

    第20回(2012年度)バイエル循環器病研究助成

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    Authorship:Principal investigator  Grant type:Contract research

  • レドックスナビ研究拠点 若手育成事業

    2010.4 - 2017.3

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    Authorship:Principal investigator 

    脳梗塞におけるペリサイトの役割解明

  • 脳梗塞機能回復過程におけるペリサイトの役割とレドックスによる制御

    2010 - 2016

    レドックスナビ若手育成事業

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 脳梗塞後の神経再生における脳血管ペリサイトの機能に関する研究

    Grant number:22590937  2010 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Scientific research funding

  • レドックスによる血管内皮細胞の機能および病態の制御

    2009.4 - 2013.3

      More details

    Authorship:Principal investigator 

  • レドックスによる血管内皮細胞機能制御に関する研究

    Grant number:21390243  2009 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 動脈硬化発症における血管内皮細胞レドックスの役割.

    2009 - 2011

    武田科学振興財団 医学系研究奨励(生活習慣病)

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    Authorship:Principal investigator  Grant type:Contract research

  • 脳梗塞・修復機構の解明と再生治療の探索

    2008.4

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    Authorship:Principal investigator 

  • 脳・心疾患におけるNox4の役割解明 International coauthorship

    2008.4

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    心血管疾患におけるNox4の役割解明

  • Fukuoka Stroke Registry

    2007.4

  • 活性酸素種による心血管疾患発症機構の解明

    2005 - 2007

    上原記念生命科学財団 リサーチフェローシップ

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    Authorship:Principal investigator  Grant type:Contract research

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Class subject

  • 老年病学 高齢者の脳血管障害の特徴と病態

    2023.10 - 2024.3   Second semester

  • 頭頸部の診察

    2023.4 - 2024.3   Full year

  • ゲノム薬理学とEBM 脳血管疾患のエビデンス構築状況

    2023.4 - 2024.3   Full year

  • 老年病学 高齢者の脳血管障害の特徴と病態

    2022.10 - 2023.3   Second semester

  • 頭頸部の診察

    2022.4 - 2023.3   Full year

  • ゲノム薬理学とEBM 脳血管疾患のエビデンス構築状況

    2022.4 - 2023.3   Full year

  • 神経(脳血管障害総論)

    2021.10 - 2022.3   Second semester

  • ゲノム薬理学とEBM 脳血管疾患のエビデンス構築状況

    2021.10 - 2022.3   Second semester

  • 老年病学 高齢者の脳血管障害の特徴と病態

    2021.10 - 2022.3   Second semester

  • 頭頸部の診察

    2021.10 - 2022.3   Second semester

  • 頭頸部の診察

    2020.10 - 2021.3   Second semester

  • 神経(脳血管障害総論)

    2020.10 - 2021.3   Second semester

  • ゲノム薬理学とEBM 脳血管疾患のエビデンス構築状況

    2020.10 - 2021.3   Second semester

  • 老年病学 高齢者の脳血管障害の特徴と病態

    2020.10 - 2021.3   Second semester

  • ゲノム薬理学とEBM 脳血管疾患のエビデンス構築状況

    2019.10 - 2020.3   Second semester

  • 老年病学 高齢者の脳血管障害の特徴と病態

    2019.10 - 2020.3   Second semester

  • 頭頸部の診察

    2019.10 - 2020.3   Second semester

  • 神経(脳血管障害総論)

    2018.10 - 2019.3   Second semester

  • ゲノム薬理学とEBM 脳血管疾患のエビデンス構築状況

    2018.10 - 2019.3   Second semester

  • 老年病学 高齢者の脳血管障害の特徴と病態

    2018.10 - 2019.3   Second semester

  • 頭頸部の診察

    2018.10 - 2019.3   Second semester

  • 神経(脳血管障害総論)

    2017.10 - 2018.3   Second semester

  • ゲノム薬理学とEBM 脳血管疾患のエビデンス構築状況

    2017.10 - 2018.3   Second semester

  • 神経(脳血管障害総論)

    2016.10 - 2017.3   Second semester

  • 神経(脳血管障害総論)

    2015.10 - 2016.3   Second semester

  • 神経(脳血管障害総論)

    2014.10 - 2015.3   Second semester

  • 神経(脳血管障害総論)

    2013.10 - 2014.3   Second semester

  • 神経(脳梗塞各論)

    2012.10 - 2013.3   Second semester

  • 神経(脳梗塞各論)

    2011.10 - 2012.3   Second semester

  • 神経(脳出血各論)

    2010.10 - 2011.3   Second semester

  • 神経(脳出血各論)

    2009.10 - 2010.3   Second semester

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Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2023  名古屋市立大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2022  名古屋市立大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  名古屋市立大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2020  名古屋市立大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2019  名古屋市立大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2018  名古屋市立大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

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Participation in international educational events, etc.

  • 2024.1

    九州大学・漢陽大学

    日韓学生交流プログラム

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    Venue:福岡

Social Activities

  • 脳梗塞発症予防に関する啓発活動

    日本脳卒中協会  エルガーラホール,福岡  2019.5

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

    年に一度,5月末の脳卒中週間に,市民啓発活動として,市民公開講座を継続的に行っている.

  • 脳梗塞発症予防に関する啓発活動

    日本脳卒中協会  エルガーラホール,福岡  2018.5

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

    年に一度,5月末の脳卒中週間に,市民啓発活動として,市民公開講座を継続的に行っている.

  • 脳梗塞発症予防に関する啓発活動

    日本脳卒中協会  エルガーラホール,福岡  2017.5

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 脳梗塞発症予防に関する啓発活動

    日本脳卒中協会  エルガーラホール,福岡  2016.5

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 脳梗塞発症予防に関する啓発活動

    日本脳卒中協会  エルガーラホール,福岡  2015.5

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 脳梗塞発症予防に関する啓発活動

    日本脳卒中協会  エルガーラホール,福岡  2014.5

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 脳梗塞発症予防に関する啓発活動

    日本脳卒中協会  エルガーラホール,福岡  2013.5

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 脳梗塞発症予防に関する啓発活動

    日本脳卒中協会  エルガーラホール,福岡  2012.5

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

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Travel Abroad

  • 2005.4 - 2008.3

    Staying countory name 1:United States   Staying institution name 1:UMDNJ-New Jersey Medical School

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / General Internal Medicine (including psychosomatic medicine)

    脳血管障害の臨床を得意とする

Clinician qualification

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

  • Specialist

    The Japan Stroke Society

  • Preceptor

    The Japanese Society of Internal Medicine(JSIM)

  • 評議員

    日本脳循環代謝学会

Year of medical license acquisition

  • 1993

Notable Clinical Activities

  • 大学病院における脳血管障害の,急性期ホットライン,他科コンサルト,に対応している