Degree
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ー
Research History
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Kyushu University Lecturer
2025.4
Country:Japan
Research Interests・Research Keywords
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Research theme: dermatology
Keyword: dermatology
Research period: 2014.8
Professional Memberships
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日本皮膚科学会
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日本アレルギー学会
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日本皮膚免疫アレルギー学会
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日本研究皮膚科学会
Research Projects
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Grant number:24K19176 2024 - 2026
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Early-Career Scientists
冬野 洋子
Authorship:Principal investigator Grant type:Scientific research funding
全身性エリテマトーデス(SLE)の治療は、これまでステロイド内服などの免疫抑制剤が治療の主体であったが、近年ステロイドを減薬させることができるような、長期的に安全な新規治療薬の開発が望まれている。炎症性皮膚疾患の新たな治療ターゲットとして、AHR(Aryl hydrocarbon receptor; 芳香族炭化水素受容体)が注目されている。本研究ではAHRをターゲットとしたSLE皮疹に対する新たな治療法の開発を目指す。
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Novel therapy targeting autophagy/LAP balance in SLE skin eruption
Grant number:22K16265 2022 - 2023
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Early-Career Scientists
Fuyuno Yoko
Authorship:Principal investigator Grant type:Scientific research funding
The activation kinetics of the AHR, NRF2, and EGFR pathways were examined in NHEK when autophagy was induced, inhibited, or LAP inhibited. It was determined that CYP1A1 tended to increase regardless of autophagy/LAP, which may be due to reagent characteristics, and that autophagy/LAP balance and activation of the AHR could not be evaluated with autophagy inducers/inhibitors or LAP inhibitors. Stimulation of keratinocytes with synthetic nucleic acid and IFNα resulted in the appearance of SLE skin rash-like signals. Further treatment with AHR ligand showed suppression of some of the above SLE-like skin rash signals.
Clinician qualification
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Specialist
Japanese Society of Allergology
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Specialist
The Japanese Dermatological Association
Year of medical license acquisition
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2006