SHIBAHARA DAISUKE
Organization
Faculty of Medical Sciences Research Institute for Deseases of the Chest Assistant Professor
School of Medicine Department of Medicine（Joint Appointment）
Title
Assistant Professor
Profile
臨床：入院・外来診療
研究：肺癌基礎研究
教育：医学生への講義
External link
ORCID
Degree
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Doctor of Philosophy in Medicine
Research Interests・Research Keywords
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Research theme：Mechanisms of drug resistance in lung cancer Tumor immune microenvironment
Keyword：Lung cancer, resistance, tumor immune microenvironment
Research period： 2023.4 - 2024.4
Papers
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TIP60 is required for tumorigenesis in non-small cell lung cancer Reviewed International journal
Daisuke Shibahara, Naoki Akanuma, Ikei S. Kobayashi, Eunyoung Heo, Mariko Ando, Masanori Fujii, Feng Jiang, P. Nicholas Prin, Gilbert Pan, Kwok-Kin Wong, Daniel B. Costa, Deepak Bararia, Daniel G. Tenen, Hideo Watanabe, Susumu S. Kobayashi
Cancer Science 2023.6
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Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer Invited Reviewed International journal
Yukie Kashima, Daisuke Shibahara, Ayako Suzuki, Kyoko Muto, Ikei S. Kobayashi, David Plotnick, Hibiki Udagawa, Hiroki Izumi, Yuji Shibata, Kosuke Tanaka, Masanori Fujii, Akihiro Ohashi, Masahide Seki, Koichi Goto, Katsuya Tsuchihara, Yutaka Suzuki, Susumu S. Kobayashi
Cancer Research 2021.9
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Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non-Small Cell Lung Cancer Invited Reviewed International journal
Daisuke Shibahara, Kentaro Tanaka, Eiji Iwama, Naoki Kubo, Keiichi Ota, Koichi Azuma, Taishi Harada, Jiro Fujita, Yoichi Nakanishi, Isamu Okamoto
Journal of Thoracic Oncology 2018.7
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Bevacizumab for Brain Radiation Necrosis in Patients With Nonsquamous Nonsmall Cell Lung Cancer Reviewed International journal
Shibahara D., Tanaka K., Togao O., Shiraishi Y., Yoneshima Y., Iwama E., Yoshitake T., Ishigami K., Okamoto I.
Clinical Lung Cancer 25 ( 6 ) 581 - 586.e3 2024.9 （ ISSN:15257304 ）
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Osimertinib readministration for central nervous system metastases in non-small cell lung cancer positive for EGFR activating mutations Invited Reviewed International journal
Yu Inutsuka, Eiji Iwama, Yoshimasa Shiraishi, Yasuto Yoneshima, Daisuke Shibahara, Kentaro Tanaka, Isamu Okamoto
Respiratory Investigation 2024.5
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Tracheomediastinal fistula induced by concurrent chemoradiotherapy in small cell lung cancer: A case report and literature review Reviewed International journal
Yamamoto, Y; Shibahara, D; Mori, T; Otsubo, K; Shiraishi, Y; Yoneshima, Y; Iwama, E; Tanaka, K; Oda, Y; Okamoto, I
THORACIC CANCER 15 ( 13 ) 1106 - 1111 2024.5 （ ISSN:1759-7706 eISSN:1759-7714 ）
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YAP mediates resistance to EGF-induced apoptosis in EGFR-mutated non-small cell lung cancer cells Invited Reviewed International journal
Maako Nakajima, Kentaro Tanaka, Yasuto Yoneshima, Sho Yamashita, Daisuke Shibahara, Eiji Iwama, Isamu Okamoto
Biochemical and Biophysical Research Communications 2023.11
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Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer Invited Reviewed International journal
Shinichi Kimura, Taishi Harada, Kayo Ijichi, Kentaro Tanaka, Renpeng Liu, Daisuke Shibahara, Yuko Kawano, Kohei Otsubo, Yasuto Yoneshima, Eiji Iwama, Yoichi Nakanishi, Isamu Okamoto
Lung Cancer 2018.6
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CD44 variant-dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment Invited Reviewed International journal
Yuko Kawano, Eiji Iwama, Kenji Tsuchihashi, Daisuke Shibahara, Taishi Harada, Kentaro Tanaka, Osamu Nagano, Hideyuki Saya, Yoichi Nakanishi, Isamu Okamoto
Lung Cancer 2017.11
Books
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EGFR-Directed Therapy in Lung Cancer
So Yeon Kim, Daniel B. Costa, Daisuke Shibahara, Susumu Kobayashi and Balazs Halmos（ Role： Joint author）
Cambridge University Press 2023.1
Presentations
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EGFR遺伝子変異陽性肺癌におけるDrug tolerant persister細胞による耐性獲得のメカニズム
柴原大典
第92回日本呼吸器学会・日本結核 非結核性抗酸菌症学会 九州支部 春季学術講演会 2024.3
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非小細胞肺癌におけるTIP60の役割
第64回日本肺癌学会学術集会 2023.11
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TIP60 is required for tumorigenesis in non-small cell lung cancer
Daisuke Shibahara, Naoki Akanuma, Ikei S. Kobayashi, Eunyoung Heo, Mariko Ando, Masanori Fujii, Feng Jiang, P. Nicholas Prin, Gilbert Pan, Kwok-Kin Wong, Daniel B. Costa, Deepak Bararia, Daniel G. Tenen, Hideo Watanabe, and Susumu S. Kobayashi
2023.9
Research Projects
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EGFR遺伝子変異陽性肺癌におけるDrug tolerant persister細胞の新規遺伝子の同定
2023.4
九州大学大学院医学研究院
Authorship：Principal investigator
EGFR遺伝子変異陽性肺癌は、分子標的薬の治療に著効するが耐性獲得は必発であり、耐性獲得機序の解明及び新規治療薬の開発は急務である。分子標的薬による治療過程で癌細胞は様々な耐性を獲得するが、その前段階の状態としてDrug tolerant persister (DTP) 細胞という概念がある。治療開始して腫瘍は一旦縮小していくが、残存病変の中に細胞死を回避して生き残った細胞が存在する。この生き残った細胞をDTP細胞といい、DTP細胞が様々な耐性機序を獲得することで、最終的に臨床で問題となる腫瘍増大につながる。そこで本研究では、DTP細胞に発現する新規遺伝子を同定し、その機能を明らかにする。加えて、その遺伝子を阻害することによってより強力な治療効果を発揮し、ひいては耐性獲得の克服も目指す。
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EGFR遺伝子変異陽性肺癌におけるDrug tolerant persister細胞の新規遺伝子の同定
Grant number：23K19544 2023 - 2024
日本学術振興会 科学研究費助成事業 研究活動スタート支援
Authorship：Principal investigator Grant type：Scientific research funding
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新日本先進医療研究財団助成
2023
Grant type：Donation
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２０２３年度 日本イーライリリーイノベーション研究助成
2023
Grant type：Donation
Class subject
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人工呼吸器管理
2023.10 - 2024.3 Second semester
Travel Abroad
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2020.8 - 2023.3
Staying countory name 1：United States Staying institution name 1：Beth Israel Deaconess Medical Center/Harvard Medical School
Specialized clinical area
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Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Respiratory Medicine
Clinician qualification
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Specialist
The Japanese Respiratory Society
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Specialist
Japanese Association for Acute Medicine（JAAM）
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Specialist
The Japanese Society of Internal Medicine（JSIM）
Year of medical license acquisition
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2007