Updated on 2024/10/01

Information

 

写真a

 
TOMIYAMA HIROFUMI
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Profile
Investigating genetic vulnerability to the obsessive-compulsive disorder
External link

Degree

  • Doctor of Medical Science

Research Interests・Research Keywords

  • Research theme:Investigating the neurobiological mechanism of Obsessive-compulsive disorder (cognitive dysfunction, neuroimaging)

    Keyword:Obsessive-compulsive disorder, cognitive function, neuroimaging, MRI

    Research period: 2020.6

Papers

  • No significant alteration in white matter microstructure in first-degree relatives of patients with obsessive-compulsive disorder Reviewed

    Tomiyama, H; Murayama, K; Nemoto, K; Kato, K; Matsuo, A; Kang, MG; Sashikata, K; Togao, O; Nakao, T

    Psychiatry Research: Neuroimaging   344   111884   2024.10   ISSN:0925-4927 eISSN:1872-7506

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Psychiatry Research - Neuroimaging  

    Obsessive-compulsive disorder (OCD) is characterized by structural alteration within white matter tissues of cortico-striato-thalamo-cortical, temporal and occipital circuits. However, the presence of microstructural changes in the white matter tracts of unaffected first-degree relatives of patients with OCD as a vulnerability marker remains unclear. Therefore, here, diffusion-tensor magnetic resonance imaging (DTI) data were obtained from 29 first-degree relatives of patients with OCD and 59 healthy controls. We investigated the group differences in FA using whole-brain analysis (DTI analysis). For additional regions of interest (ROI) analysis, we focused on the posterior thalamic radiation and sagittal stratum, shown in recent meta-analysis of patients with OCD. In both whole-brain and ROI analyses, using a strict statistical threshold (family-wise error rate [FWE] corrected p<.05 for whole-brain analyses, and p<.0125 (0.05/4) with Bonferroni correction for ROI analyses), we found no significant group differences in FA. Subtle reductions were observed in the anterior corona radiata, forceps minor, cingulum bundle, and corpus callosum only when a lenient statistical was applied (FWE corrected p<.20). These findings suggest that alterations in the white matter microstructure of first-degree relatives, as potential vulnerability markers for OCD, are likely subtle.

    DOI: 10.1016/j.pscychresns.2024.111884

    Web of Science

    Scopus

    PubMed

  • Posterior cingulate cortex spontaneous activity associated with motor response inhibition in patients with obsessive-compulsive disorder: A resting-state fMRI study Reviewed International journal

    Tomiyama.H, Murayama.K, Nemoto.K, Tomita.M, Hasuzawa.S, Mizobe.T, Kato.K, Matsuo.A, Ohno.A, Kan.M, Togao.O, Hiwatashi.A, Ishigami.K, Nakao.T

    Psychiatry Research: Neuroimaging   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pscychresns.2023.111669

  • Gyrification of the medial and lateral orbitofrontal cortex in first-degree relatives of patients with obsessive-compulsive disorder Reviewed International journal

    Tomiyama.H, Murayama.K, Nemoto.K, Kato.K, Matsuo. A, Ohno.A, Mingi.K, Togao.O, Ishigami.K, Nakao.T

    Cerebral Cortex   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/cercor/bhad170

  • The functional connectome in obsessive-compulsive disorder : resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium Reviewed International coauthorship International journal

    Molecular Psychiatry   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41380-023-02077-0

  • Functional connectivity between pre-supplementary motor area and inferior parietal lobule associated with impaired motor response inhibition in first-degree relatives of patients with obsessive-compulsive disorder Reviewed International journal

    Tomiyama.H, Murayama.K, Nemoto.K, Tomita.M, Kato.K, Matsuo.A, Ohno.A, Kang.M, Togao.O, Ishigami.K, Nakao.T

    Cerebral Cortex   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1093/cercor/bhad058

  • Alterations of default mode and cingulo-opercular salience network and frontostriatal circuit : A candidate endophenotype of obsessive-compulsive disorder Reviewed International journal

    Tomiyama.H, Murayama.K, Nemoto.K, Hasuzawa.S, Mizobe.T, Kato.K, Matsuo.A, Ohno.A, Kang.M, Togao.O, Hiwatashi.A, Ishigami.K, Nakao.T

    Progress in Neuropsychopharmacology & Biological Psychiatry   116 ( 8 )   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pnpbp.2022.110516

  • Increased functional connectivity between presupplementary motor area and inferior frontal gyrus associated with the ability of motor response inhibition in obsessive–compulsive disorder Reviewed International journal

    Human Brain Mapping   Feb ( 15 )   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hbm.25699

  • Dysfunction between dorsal caudate and salience network associated with impaired cognitive fl exibility in obsessive-compulsive disorder : A resting- state fMRI study Reviewed International journal

    Tomiyama.H, Nakao.T, Murayama.K, Nemoto.K, Ikari.K, Yamada.S, Kuwano.M, Hasuzawa.S, Togao.O, Hiwatashi.A, Kanba.S

    NeuroImage: Clinical   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.nicl.2019.102004

  • Reduced resting-state functional connectivity between insula and inferior frontal gyrus and superior temporal gyrus in hoarding disorder

    Kato, K; Tomiyama, H; Murayama, K; Mizobe, T; Matsuo, A; Nishida, N; Matukuma, K; Kang, MG; Sashikata, K; Kikuchi, K; Togao, O; Nakao, T

    FRONTIERS IN PSYCHIATRY   15   1399062   2024.6   ISSN:1664-0640

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    Language:English   Publisher:Frontiers in Psychiatry  

    Background: Hoarding disorder (HD) is characterized by cognitive control impairments and abnormal brain activity in the insula and anterior cingulate cortex (ACC) during disposal of personal items or certain executive function tasks. However, whether there are any changes in resting-state functional connectivity of the insula and ACC remains unclear. Methods: A total of 55 subjects, including 24 patients with HD and 31 healthy controls (HCs), participated in the study. We acquired resting-state functional magnetic resonance imaging data and examined group differences in functional connectivity from the insula and ACC in whole-brain voxels. Results: In patients with HD, functional connectivity was significantly lower between the right insula and right inferior frontal gyrus (IFG) and left superior temporal gyrus (STG) compared to HCs. There was no correlation between these connectivities and HD symptoms. Conclusions: Although the clinical implication is uncertain, our results suggest that patients with HD have resting-state functional alterations between the insula and IFG and STG, corresponding with the results of previous fMRI studies. These findings provide new insight into the neurobiological basis of HD.

    DOI: 10.3389/fpsyt.2024.1399062

    Web of Science

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    PubMed

  • Decision-making deficits in obsessive-compulsive disorder are associated with abnormality of recency and response consistency parameter in prospect valence learning model Reviewed International journal

    Murayama, K. Tomiyama, H. Ohno, A. Kato, K. Matsuo, A. Hasuzawa, S. Sashikata, K. Kang, M. Nakao, T.

    Front Psychiatry   14   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fpsyt.2023.1227057

  • Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects

    Hasuzawa, S; Tomiyama, H; Murayama, K; Ohno, A; Kang, MG; Mizobe, T; Kato, K; Matsuo, A; Kikuchi, K; Togao, O; Nakao, T

    FRONTIERS IN PSYCHIATRY   13   836965   2022.5   ISSN:1664-0640

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    Language:English   Publisher:Frontiers in Psychiatry  

    Background: Symptoms of obsessive-compulsive disorder (OCD) have been conceptualized as manifestations of decision-making deficits. Patients with OCD exhibit impairment during the decision-making process, as assessed by the Iowa Gambling Task (IGT). This impairment is independent of clinical severity and disease progression. However, the association between the decision-making deficit and resting-state brain activity of patients with OCD has not been examined. Methods: Fifty unmedicated patients with OCD and 55 matched control subjects completed IGT. Resting-state brain activity was examined using the fractional amplitude of low-frequency fluctuations (fALFFs). fALFF analysis focused on the slow-4 and 5 bands. Group comparisons were performed to determine the association between IGT performance and fALFFs. Results: There was a significant group difference in the association between the IGT total net score and slow-4 fALFFs in the left putamen (voxel height threshold of p < 0.001; cluster size threshold of p < 0.05; family wise error-corrected). Higher putamen slow-4 fALFFs were correlated with lower IGT scores for OCD patients (r = −0.485; p < 0.0005) and higher IGT scores for control subjects (r = 0.402; p < 0.005). There was no group difference in the association between the IGT total net score and slow-5 fALFFs. Conclusions: These findings in unmedicated patients demonstrate the importance of resting-state putamen activity for decision-making deficit associated with OCD, as measured by IGT. The inverse correlation may be explained by the hypersensitive response of the putamen in patients with OCD.

    DOI: 10.3389/fpsyt.2022.836965

    Web of Science

    Scopus

    PubMed

  • Abnormal white matter structure in hoarding disorder Reviewed International journal

    Mizobe.T, Ikari.K, Tomiyama.H, Murayama.K, Kato.K, Hasuzawa.S, Togao.O, Hiwatashi.A, Nakao.T

    Journal of Psychiatric Research   148   1 - 8   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jpsychires.2022.01.031

  • Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Unmedicated Patients With Obsessive-Compulsive Disorder Reviewed International journal

    Murayama, K., Tomiyama, H., Tsuruta, S., Ohono, A., Kang, M., Hasuzawa, S., Mizobe, T., Kato, K., Togao, O., Hiwatashi, A. & Nakao, T.

    Frontiers in Psychiatry   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI Reviewed International journal

    Momosaka, D., Togao, O., Hiwatashi, A., Yamashita, K., Kikuchi, K., Tomiyama, H., Nakao, T., Murayama, K., Suzuki, Y. & Honda, H.

    PLOS ONE   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Impacts of Stressful Life Events and Traumatic Experiences on Onset of Obsessive-Compulsive Disorder Reviewed International journal

    Murayama, K., Nakao, T., Ohno, A., Tsuruta, S., Tomiyama, H., Hasuzawa, S., Mizobe, T., Kato, K. & Kanba, S

    Frontiers in Psychiatry   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Clinical characteristics of hoarding disorder in Japanese patients Reviewed International journal

    Kuwano, M., Nakao, T., Yonemoto, K., Yamada, S., Murayama, K., Okada, K., Honda, S., Ikari, K., Tomiyama, H., Hasuzawa, S. & Kanba, S

    Heliyon   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  • A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder Reviewed International journal

    Yamada.S, Nakao.T, Ikari.K, Kuwano.M, Murayama.K, Tomiyama.H, Hasuzawa.S, Togao.O, Hiwatashi.A, Kanba.S

    PLOS ONE   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0200814

  • Morphologic and clinical differences between Early- and Late-onset obsessive-compulsive disorder: Voxel-based Morphometric study Reviewed International journal

    Keisuke Ikari, Tomohiro Nakao, Kiyotaka Nemoto, Kayo Okada, Keitaro Murayama, Shinichi Honda, Masumi Kuwano, Satoshi Yamada, Hirofumi Tomiyama, Mayumi Tomita, Osamu Togao, Akio Hiwatashi, Shigenobu Kanba

    Journal of Obsessive-Compulsive and Related Disorders   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jocrd.2017.02.005

  • Antipsychotic switching versus augmentation among early non-responders to risperidone or olanzapine in acute-phase schizophrenia Reviewed International journal

    Kotaro Hatta, Taro Otachi, Kiyoshi Fujita, Fumiyoshi Morikawa, Shin Ito, Hirofumi Tomiyama, Takayuki Abe, Yasuhiko Sudo, Hiroshi Takebayashi, ToruYamashita, Shigemasa Katayama, Reiko Nakase, Yutaka Shirai, Chie Usui,Hiroyuki Nakamura, Hiroto Ito, Toyoaki Hirata, Yutaka Sawa.

    Schizophrenia Research   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

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Presentations

  • 強迫症の脳神経基盤 Invited

    豊見山泰史

    第119回 日本精神神経学会学術総会  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 強迫症対策医療研修 認知行動療法コース 模擬カンファレンス Invited

    中尾智博、松尾陽、村山桂太郞、豊見山泰史

    強迫症対策医療研修 認知行動療法コース  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 強迫症の認知行動療法 治療マニュアルの解説 Invited

    豊見山泰史

    厚生労働省 研修事業 強迫症の認知行動療法研修会 一日研修  2023.2 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 認知行動療法マニュアルを用いた強迫症の治療 Invited

    村山桂太郞、豊見山泰史、中尾智博

    日本認知療法・認知行動療法学会 第22回大会  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 強迫症 総論 初診時面接 Invited

    豊見山泰史

    第1回 強迫症対策医療研修 認知行動療法コース  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 強迫症のCBT Invited

    中川彰子、中尾智博、豊見山泰史

    日本認知・行動療法学会 第48回大会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 行動活性化 Invited

    豊見山泰史

    厚生労働省研修事業 認知行動療法ワークショップ  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 認知行動療法ワークショップ 「不安症の認知行動療法 強迫症」 Invited

    豊見山泰史

    厚生労働省研修事業  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 思春期青年期の発達障害 発達障害の生物学的基盤 Invited

    豊見山泰史

    福岡県医師会発達障がい者地域包括支援研修 伝達研修  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 強迫症の認知行動療法 治療マニュアルの解説 Invited

    豊見山泰史

    日本認知・行動療法学会 第47回大会  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 「九州大学病院における認知行動療法の取り組み」第20回日本認知療法・認知行動療法学会 大会企画シンポジウム 2020.11.21 Invited

    豊見山泰史

    第20回日本認知療法・認知行動療法学会 大会企画シンポジウム 2020.11.21  2020.11 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 厚労省治療マニュアルを用いた強迫症の認知・行動療法 パート2 Invited

    豊見山泰史

    認知・行動療法学会  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • 薬物療法およびモデリングによる介入が奏功した強迫症の一例

    河村 健太郎, 加藤 研太, 豊見山 泰史, 村山 桂太郎, 中尾 智博

    九州神経精神医学  2023.8  九州精神神経学会

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    Language:Japanese  

  • 強迫症の認知行動療法における多様な治療形式と脳画像研究の展望 強迫症の脳画像研究と認知行動療法

    豊見山 泰史

    日本認知療法・認知行動療法学会プログラム・抄録集  2023.11  日本認知療法・認知行動療法学会

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    Language:Japanese  

  • 強迫症の理解と治療戦略のアップデート 強迫症の基本的な治療戦略と脳神経基盤

    豊見山 泰史

    精神神経学雑誌  2023.6  (公社)日本精神神経学会

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    Language:Japanese  

  • 強迫症における反応抑制障害は罹病期間と相関を認めるか? Stop Signal Taskを用いた反応抑制障害の研究

    村山 桂太郎, 豊見山 泰史, 指方 賢太, Kang Mingi, 加藤 研太, 松尾 陽, 大野 愛哉, 中尾 智博

    日本認知・行動療法学会大会プログラム・抄録集  2023.10  (一社)日本認知・行動療法学会

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    Language:Japanese  

  • 入院による認知行動療法及び薬物療法が奏功した強迫症の一例

    森口 浩史, 松尾 陽, 豊見山 泰史, 村山 桂太郎, 中尾 智博

    九州神経精神医学  2023.8  九州精神神経学会

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    Language:Japanese  

  • ためこみ症発症の臨床因子に関する検討 所有物への信念とライフイベント

    加藤 研太, 村山 桂太郎, 豊見山 泰史, 松尾 陽, 中尾 智博

    日本認知・行動療法学会大会プログラム・抄録集  2022.9  (一社)日本認知・行動療法学会

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    Language:Japanese  

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MISC

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Professional Memberships

  • The japanese society of psychiatry and neurology

Academic Activities

  • 精神神経学雑誌

    2022.6 - 2023.4

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    Type:Academic society, research group, etc. 

Research Projects

  • Abnormal cortical gyrification and executive function involvement in hoarding disorder.

    Grant number:24K10681  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

    CiNii Research

  • チック関連強迫性障害におけるendophenotypeの同定

    Grant number:22K07598  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    村山 桂太郎, 中尾 智博, 豊見山 泰史, 栂尾 理

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    Grant type:Scientific research funding

    強迫性障害(obsessive-compulsive disorder: OCD)の約30%はチック症を併存し、チック症関連のOCDはより遺伝的な要因の影響が強いことが知られている。
    本研究では、遺伝的な要因の関与がより大きいチック関連のOCD患者とその第一度近親者を対象とし、脳画像解析と神経心理機能検査を用いて、endophenotype(中間表現型)の調査を行い、OCDの臨床的異種性および脳画像と神経心理検査を用いた生物学的異種性を明らかにすることが目的である。

    CiNii Research

  • 注意欠如/多動性障害の反応抑制障害の基盤となる安静時の大域的脳ネットワークの検索

    Grant number:22K15766  2022 - 2026

    日本学術振興会  科学研究費助成事業  若手研究

    豊見山 泰史

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    Authorship:Principal investigator  Grant type:Scientific research funding

    注意欠如/多動性障害(ADHD)は、不注意、多動・衝動性を特徴とする神経発達症の一つであり、衝動性の基盤となる実行機能障害の一つに反応抑制障害がある。しかしADHDの反応抑制障害と関連する安静時の脳ネットワークは明らかではない。本研究は成人ADHDの反応抑制障害の基盤となる安静時大域的脳ネットワークを検索することを目的とする。本研究で得られる知見は、ADHDの病態の理解および衝動性をターゲットとした新たな治療法の開発につながる可能性がある。

    CiNii Research

  • Investigation of the brain structural abnormalities in Hoarding Disorder by using diffusionte

    Grant number:21K07547  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

    CiNii Research