Increased Lung Uric Acid Deteriorates Pulmonary Arterial Hypertension. Reviewed International journal

Watanabe T, Ishikawa M, Abe K, Ishikawa T, Imakiire S, Masaki K, Hosokawa K, Fukuuchi T, Kaneko K, Ohtsubo T, Hirano M, Hirano K, Tsutsui H.

J Am Heart Assoc.   10 ( 23 )   e022712   2021.10

A ‘Mille-Feuille’-like giant dissecting aneurysmof the pulmonary artery in Eisenmenger syndrome. Reviewed International journal

42 ( 1 )   137   2021.5

Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats. Reviewed International journal

Ishikawa T, Abe K, Takana-Ishikawa M, Yoshida K, Watanabe T, Imakiire S, Hosokawa K, Hirano M, Hirano K, Tsutsui H.

J Am Heart Assoc.   10 ( 7 )   e019247   2021.3

Right Ventricular Extracellular Volume with Dual-Layer Spectral Detector CT: Value in Chronic Thromboembolic Pulmonary Hypertension. Reviewed International journal

Yamasaki Y, Abe K, Kamitani T, Sagiyama K, Hida T, Hosokawa K, Matsuura Y, Hioki K, Nagao M, Yabuuchi H, Ishigami K.

Radiology.   26   203719   2021.3

Japan Pulmonary Hypertension Registry (JAPHR) Network.Improvements in French risk stratification score were correlated with reductions in mean pulmonary artery pressure in pulmonary arterial hypertension: a subanalysis of the Japan Pulmonary Hypertension Registry (JAPHR). Reviewed International journal

Tamura Y, Kumamaru H, Abe K, Satoh T, Miyata H, Ogawa A, Tanabe N, Hatano M, Yao A, Tsujino I, Fukuda K, Kimura H, Kuwana M, Matsubara H, Tatsumi K

BMC Pulm Med.   14   21(1):28   2021.1

Multistage Strategy With Perfusion SPECT and CT Pulmonary Angiogram in Balloon Pulmonary Angioplasty for Totally Occluded Lesions in CTEPH. Reviewed International journal

Hosokawa K, Abe K, Yamasaki Y, Tsutsui H.

EuroIntervention.   EIJ-D-20-00652   2020.5

Balloon Pulmonary Angioplasty Improves Right Atrial Reservoir and Conduit Functions in Chronic Thromboembolic Pulmonary Hypertension. Reviewed International journal

Yamasaki Y, Abe K, Kamitani T, Hosokawa K, Kawakubo M, Sagiyama K, Hida T, Matsuura Y, Murayama Y, Funatsu R, Tsutsui H, Yabuuchi H.

Eur Heart J Cardiovasc Imaging.   2020.4

A Novel Pulmonary Circulation Imaging using Dynamic Digital Radiography for Chronic Thromboembolic Pulmonary Hypertension. Invited Reviewed International journal

Yamasaki Y, Abe K, Hosokawa K, Kamitani T.

Eur Heart J.   2020.2

Use of direct oral anticoagulants prevents increase in pulmonary vascular resistance and incidence of clinical worsening in patients with chronic thromboembolic pulmonary hypertension. Reviewed International journal

Hosokawa K, Abe K, Tsutsui H.

Thromb Res.   2019.6

Japanese Circulation Society and the Japanese Pulmonary Circulation and Pulmonary Hypertension Society Joint Working Group. Guidelines for the Treatment of Pulmonary Hypertension (JCS 2017/JPCPHS 2017). Invited Reviewed International journal

Fukuda K, Date H, Doi S, Fukumoto Y, Fukushima N, Hatano M, Ito H, Kuwana M, Matsubara H, Momomura SI, Nishimura M, Ogino H, Satoh T, Shimokawa H, Yamauchi-Takihara K, Tatsumi K, Ishibashi-Ueda H, Yamada N, Yoshida S, Abe K, Ogawa A, Ogo T, Kasai T, Kataoka M, Kawakami T, Kogaki S, Nakamura M, Nakayama T, Nishizaki M, Sugimura K, Tanabe N, Tsujino I, Yao A, Akasaka T, Ando M, Kimura T, Kuriyama T, Nakanishi N, Nakanishi T, Tsutsui H

Circ J.   25 ( 83(4) )   842 - 945   2019.6

Traditional Screening Tool in the Era of Modern Treatment for Chronic Thromboembolic Pulmonary Hypertension. Invited Reviewed International journal

Abe K, Hosokawa K, Tsutsui H.

Int J Cardiol.   280 ( 182 )   183   2019.4

Proteinase-activated Receptor 1 Antagonism Ameliorates Experimental Pulmonary Hypertension. Invited Reviewed International journal

Kuwabara Y, Tanaka-Ishikawa M, Abe K, Hirano M, Hirooka Y, Tsutsui H, Sunagawa K, Hirano K.

Cardiovasc Res.   2019.1

Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension. Reviewed International journal

Yoshida K, Saku K, Kamada K, Abe K, Tanaka-Ishikawa M, Tohyama T, Nishikawa T, Kishi T, Sunagawa K, Tsutsui H.

JACC Basic Transl Sci.   12 ( 3 )   657 - 671   2018.8

Inhibition of TLR9-NF-kB‒Mediated Sterile Inflammation Improves Pressure Overload‒Induced Right Ventricular Dysfunction in Rats. Reviewed International journal

115 ( 3 )   658 - 668   2018.6

Balloon Pulmonary Angioplasty Relieves Hemodynamic Stress towards Untreated-Side Pulmonary Vasculature and Ameliorates Its Resistance in Patients with Chronic Thromboembolic Pulmonary Hypertension. Reviewed International journal

Hosokawa K, Abe K, Horimoto K, Yamasaki Y, Nagao M, Tsutsui H.

EuroIntervention.   13 ( 17 )   2069 - 2076   2018.5

A Pro - Con debate: Current Controversies in PAH Pathogenesis at the American Thoracic Society International Meeting in 2017. Invited Reviewed International journal

Kuebler WM, Nicolls MR, Olschewski A, Abe K, Rabinovitch M, Stewart DJ, Chan SY, Morrell NW, Archer SL, Spiekerkoetter E.

Am J Physiol Lung Cell Mol Physiol.   315 ( 4 )   L502 - L516   2018.3

Three Dimensional SPECT/CT Fusion Imaging Guided Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension. Reviewed International journal

Hosokawa K, Abe K, Kashihara S, Tsutsui H.

JACC Cardiovasc Interv.   10 ( 20 )   e193 - e194   2017.10

Inhibition of Nitric Oxide Synthase Unmasks Vigorous Vasoconstriction in Established Pulmonary Arterial Hypertension. Invited Reviewed International journal

Tanaka M, Abe K, Oka M, Saku K, Yoshida K, Ishikawa T, McMurtry IF, Sunagawa K, Hoka S, Tsutsui H.

Physiol Rep.   5 ( 23 )   2017.5

Delayed-onset Lung Injury After Balloon Pulmonary Angioplasty. Reviewed International journal

Hosokawa K, Yamamoto T, Abe K, Tsutsui H.

Eur Heart J Cardiovasc Imaging.   18 ( 12 )   1426   2017.5

Optical Frequency Domain Imaging of Covered Stent-Graft for Pulmonary Artery Pseudoaneurysm after Balloon Pulmonary Angioplasty. Invited Reviewed International journal

Koshin Horimoto, Kohtaro Abe, Kisho Ohtani, Yusuke Takahara, Kazuya Hosokawa, keiji Oi, Yasushi Mukai, Takashi Kubo, Tetsuya Matoba, Hiroyuki Tsutsui

JACC Cardiovasc Interv.   14 ( 9(21) )   2255 - 2256   2016.11

Hemodynamic unloading reserses occlusive vascular lesions in severe pulmonary hypertension. Reviewed International journal

Abe K, Shinoda M, Tanaka M, Kuwabara Y, Yoshida K, Hirooka Y, Sunagawa K

Cardiovasc Res.   2016.3

Balloon pulmonary angioplasty-related complications and therapeutic strategy in patients with chronic thromboembolic pulmonary hypertension. Reviewed International journal

Hosokawa K, Abe K, Oi K, Mukai Y, Hirooka Y, Sunagawa K

Int J Cardiol.   15 ( 197 )   224 - 226   2015.6

Negative acute hemodynamic response to balloon pulmonary angioplasty does not predicate the long-term outcome in patients with chronic thromboembolic pulmonary hypertension. Reviewed International journal

Hosokawa K, Abe K, Oi K, Mukai Y, Hirooka Y, Sunagawa K

Int J Cardiol.   188   81 - 83   2015.4

Switching from Beraprost to Selexipag in the Treatment of Pulmonary Arterial Hypertension: Insights from a Phase IV Study of the Japanese Registry (The EXCEL Study: EXChange from bEraprost to seLexipag Study) Reviewed International journal

Tamura Y, Kumamaru H, Tsujino I, Suda R, Abe K, Inami T, Horimoto K, Adachi S, Yasuda S, Sera F, Taniguchi Y, Kuwana M, Tatsumi K; Japan Pulmonary Hypertension Registry Network.

Pharmaceuticals (Basel)   17 ( 5 )   555   2024.4

Recognition, diagnosis, and operability assessment of chronic thromboembolic pulmonary hypertension (CTEPH): A global cross-sectional scientific survey (CLARITY). Reviewed International journal

Pulm Circ.   14 ( 1 )   e12330   2024.3

Dynamic chest radiography for pulmonary vascular diseases: clinical applications and correlation with other imaging modalities. Reviewed International journal

Yamasaki Y, Kamitani T, Sagiyama K, Hino T, Kisanuki M, Tabata K, Isoda T, Kitamura Y, Abe K, Hosokawa K, Toyomura D, Moriyama S, Kawakubo M, Yabuuchi H, Ishigami K.

Jpn J Radiol.   42 ( 2 )   126 - 144   2024.1

Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases Reviewed International journal

Kuwabara M, Fukuuchi T, Aoki Y, Mizuta E, Ouchi M, Kurajoh M, Maruhashi T, Tanaka A, Morikawa N, Nishimiya K, Akashi N, Tanaka Y, Otani N, Morita M, Miyata H, Takada T, Tsutani H, Ogino K, Ichida K, Hisatome I, Abe K.

Biomolecules .   13 ( 10 )   1519   2023.10

Technical Considerations for Performing Safe and Effective Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension Reviewed International journal

Hosokawa K, Yamasaki Y, Abe K.

Interv Cardiol Clin .   12 ( 3 )   367 - 380   2023.7

SATISFY-JP, a phase II multicenter open-label study on Satralizumab, an anti-IL-6 receptor antibody, use for the treatment of pulmonary arterial hypertension in patients with an immune-responsive-phenotype: Study protocol. Reviewed International journal

Tamura Y, Takeyasu R, Takata T, Miyazaki N, Takemura R, Wada M, Tamura Y, Abe K, Shigeta A, Taniguchi Y, Adachi S, Inami T, Tsujino I, Tahara N, Kuwana M

Pulm Circ.   13 ( 2 )   e12251   2023.6

Beneficial Effects of Pulmonary Vasodilators on Pre-Capillary Pulmonary Hypertension in Patients with Chronic Kidney Disease on Hemodialysis. Reviewed International journal

Kimuro K, Hosokawa K, Abe K, Masaki K, Imakiire S, Sakamoto T, Tsutsui H.

Life (Basel).   24 ( 12 )   780   2023.6

Visibility of Pulmonary Valve and Pulmonary Regurgitation on Intracardiac Echocardiography in Adult Patients with Tetralogy of Fallot Reviewed International journal

Sakamoto I, Yamamura K, Ishikita A, Ohtani K, Umemoto S, Kaku H, Yamasaki Y, Abe K, Ide T, Tsutsui H.

J Cardiovasc Dev Dis.   10 ( 7 )   24   2023.6

Efficacy, safety, and pharmacokinetics of inhaled treprostinil in Japanese patients with pulmonary arterial hypertension. Reviewed International journal

Kuwana M, Abe K, Kinoshita H, Matsubara H, Minatsuki S, Murohara T, Sakao S, Shirai Y, Tahara N, Tsujino I, Takahashi K, Kanda S, Ogo T.

Pulm Circ.   13 ( 1 )   e12198   2022.12

Efficacy and Safety of Edoxaban in Patients with Chronic Thromboembolic Pulmonary Hypertension: Study Protocol of A Multicenter, Randomized, Warfarin-Controlled Trial; KABUKI Trial. Invited Reviewed International journal

Hosokawa K, Abe K, Kishimoto J, Inami T, Ikeda N, Taniguchi Y, Minatsuki S, Muyohara T, Yasuda S, Tamura Y, Tatsumi K, Kobayakawa Y, Todaka K, Tsutsui H.

BMJ Open.   in press   2022.12

Increased Pulmonary Arterial Compliance after Balloon Pulmonary Angioplasty Predicts Exercise Tolerance Improvement in Inoperable CTEPH Patients with Lower Pulmonary Arterial Pressure Reviewed International journal

Umemoto S, Abe K, Hosokawa K, Horimoto K, Saku K, Sakamoto T, Tsutsui H.

Heart Lung   52   8 - 15   2022.4

Diagnosis of Pulmonary Hypertension Using Dynamic Chest Radiography Reviewed International journal

Yamasaki Y, Kamitani T, Abe K, Hosokawa K, Sagiyama K, Hida T, Matsuura Y, Kitamura Y, Maruoka Y, Isoda T, Baba S, Yoshikawa H, Kuramoto T, Yabuuchi H, Ishigami K.

Am J Respir Crit Care Med.   204 ( 11 )   1336 - 1337   2021.12

Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension Reviewed International journal

Hiraishi K, Kurahara LH, Feng J, Yamamura A, Cui Y, Yahiro E, Yokomise H, Go T, Ishikawa K, Yokota N, Fujiwara A, Onitsuka M, Abe K, Ohga S, Satoh T, Okada Y, Yue L, Inoue R, Hirano K.

Transl Res .   233   127 - 143   2021.5

Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension. Reviewed International journal

Hiraishi K, Kurahara LH, Feng J, Yamamura A, Cui Y, Yahiro E, Yokomise H, Go T, Ishikawa K, Yokota N, Fujiwara A, Onitsuka M, Abe K, Ohga S, Satoh T, Okada Y, Yue L, Inoue R, Hirano K.

Transl Res.   7   S1931   2021.4

Preoperative Threshold for Normalizing Right Ventricular Volume after Transcatheter Closure of Adult Atrial Septal Defect. Reviewed International journal

Umemoto S, Sakamoto I, Abe K, Ishikita A, Yamasaki Y, Hiasa K, Ide T, Tsutsui H

Circ J.   84 ( 8 )   1312 - 1319   2020.5

Genetic knockout and pharmacologic inhibition of NCX1 attenuate hypoxia-induced pulmonary arterial hypertension. Reviewed International journal

Nagata A, Tagashira H, Kita S, Kita T, Nakajima N, Abe K, Iwasaki A, Iwamoto T.

Biochem Biophys Res Commun.   529 ( 3 )   793 - 798   2020.5

Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn. Reviewed International journal

Kurahara LH, Hiraishi K, Yamamura A, Zhang Y, Abe K, Yahiro E, Aoki M, Koga K, Yokomise H, Go T, Ishikawa K, Bo Z, Kishi H, Kobayashi S, Aoki-Shoi N, Toru S, Inoue R, Hirano K.

J Mol Cell Cardiol.   148   50 - 62   2020.5

Psychometric Validation of a Japanese Version of the emPHasis-10 Questionnaire, a Patient-Reported Outcome Measure for Pulmonary Hypertension -Multicenter Study in Japan- Reviewed International journal

Takeyasu R, Tamura, Y, Abe K, Goda A, Satoh, T, Suda R, Tanabe N, Tsujino I, Yamazaki T, Tatsumi K.

Circulation Reports.   2020.3

Multicentre randomised controlled trial of balloon pulmonary angioplasty and riociguat in patients with chronic thromboembolic pulmonary hypertension: protocol for the MR BPA study. Reviewed International journal

Kawakami T, Matsubara H, Abe K, Kataoka M, Kohsaka S, Sato Y, Shinke T, Fukuda K.

BMJ Open.   6 ( 10(2) )   e028831   2020.2

Peripheral pulmonic stenosis in SAPHO syndrome. Reviewed International journal

Kamada K, Hosokawa K, Abe K, Tsutsui H.

Eur Heart J.   21 ( 41(4) )   518a   2020.1

Aneurysm-type plexiform lesions form in supernumerary arteries in pulmonary arterial hypertension: potential therapeutic implications Reviewed International journal

Oshima K, Crockett ES, Joshi SR, McLendon JM, Matsumoto Y, McMurtry IF, Abe K, Oka M.

Am J Physiol Lung Cell Mol Physiol.   17 ( 6 )   L806   2019.12

Suppressed baroreflex peripheral arc overwhelms augmented neural arc and incapacitates baroreflex function in pulmonary arterial hypertension rats. Reviewed International journal

Shinoda M, Saku K, Oga Y, Tohyama T, Nishikawa T, Abe K, Yoshida K, Kuwabara Y, Fujii K, Ishikawa T, Kishi T, Sunagawa K, Tsutsui H.

Exp Physiol.   2019.6

Right ventricular area strain with routine cine MRI after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: Comparison with 2D feature tracking MRI. Reviewed International journal

Kawakubo M, Yamasaki Y, Kamitani T, Sagiyama K, Abe K, Hosokawa K, Uabuuchi H, Honda H.

Eur Radiol.   2019.3

Pulmonary arterial input impedance reflects the mechanical properties of pulmonary arterial remodeling in rats with pulmonary hypertension. Invited Reviewed International journal

Nishikawa T., Saku K., Kishi T., Tohyama T., Abe K, Oga Y., Arimura T., Sakamoto T., Yoshida K., Sunagawa K., Tsutsui H.

Life Sci.   1 ( 212 )   225 - 232   2018.6

Three-dimensional fractal analysis of 99mTc-MAA SPECT images in chronic thromboembolic pulmonary hypertension for evaluation of response to balloon pulmonary angioplasty: association with pulmonary arterial pressure. Reviewed International journal

Yasuhiro Maruoka, Michinobu Nagao, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Yuzo Yamasaki, Koichiro Abe, Masayuki Sasaki, Kohtaro Abe, Hiroshi Honda

Nucl Med Commun.   38 ( 6 )   480 - 486   2017.6

Japan PH Registry (JAPHR) Network. Effectiveness and Outcome of Pulmonary Arterial Hypertension-Specific Therapy in Japanese Patients With Pulmonary Arterial Hypertension. Reviewed International journal

Tamura Y, Kumamaru H, Satoh T, Miyata H, Ogawa A, Tanabe N, Hatano M, Yao A, Abe K, Tsujino I, Fukuda K, Kimura H, Kuwana M, Matsubara H, Tatsumi K

Circ J.   25 ( 1 )   275 - 282   2017.5

Balloon pulmonary angioplasty improves interventricular dyssynchrony in patients with inoperable chronic thromboembolic pulmonary hypertension: a cardiac MR imaging study. Reviewed International journal

Yamasaki Y, Nagao M, Abe K, Hosokawa K, Kawanami S, Kamitani T, Yamanouchi T, Horimoto K, Yabuuchi H, Honda H.

Int J Cardiovasc Imaging.   33 ( 2 )   229-239   2017.5

Subcutaneous treprostinil was effective and tolerable in a patient with severe pulmonary hypertension associated with chronic kidney disease on hemodialysis. Reviewed International journal

Takanori Watanabe, Kohtaro Abe, Koshin Horimoto, Kazuya Hosokawa, Kisho Ohtani, Hiroyuki Tsutsui

Heart Lung.   46 ( 2 )   129 - 130   2017.3

Energy efficiency and pulmonary artery flow after balloon pulmonary angioplasty for inoperable, chronic thromboembolic pulmonary hypertension: Analysis by phase-contrast MRI. Reviewed International journal

Michinobu Nagao, Yuzo Yamasaki, Kohtaro Abe, Kazuya Hosokawa, satoshi Kawanami, Takeshi Kamitani, Hidetake Yabuuchi, Kenji Fukushima, Hiroshi Honda

European Journal of Radiology   87   99 - 104   2017.2

Three-dimensional phase contrast magnetic resonance imaging validated to assess pulmonary artery flow in patients with chronic thromboembolic pulmonary hypertension Reviewed International journal

Masateru Kawakubo, Hiroshi Akamine, Yuzo Yamasaki, Atsushi Takemura, Kohtaro Abe, Kazuya Hosokawa, Junji Morishita, Michinobu Nagao

Radiological Physics and Technology   10   249 - 255   2016.10

Pulmonary Arterial Hypertension Associated with Hereditary Hemorrhagic Telangiectasia Successfully Treated with Sildenafil. Reviewed International journal

Miyake R, Fujino T, Abe K, Hosokawa K, Ohtani K, Morisaki H, Yamada O, Higo T, Ide T

Int J Cardiol.   2016.4

Reversal of diffuse patchy pattern in lung perfusion scan in a case of severe pulmonary arterial hypertension. Reviewed International journal

Kodama Y, Abe K, Hosokawa K, Ohtani K, Nagao M, Hirooka Y, Sunagawa K

Heart Lung.   44 ( 5 )   451 - 452   2015.1

(Scientific Symposium PRO/CON DEBATE) CONTROVERSIES IN PAH PATHOGENESIS Hemodynamic Stress Is the Most Important Driver in the Pathogenesis of Occlusive Neointimal Lesions in PAH. Invited International conference

2017 American Thoracic Society International Conference  2017.5 

(Plenary Session) Update on management of Pulmonary Hypertension (ASMIHA-JCS Joint Symposium) Balloon Pulmonary Angioplasty in Patients with CTEPH Invited International conference

The 26th Annual Scientific meeting of the Indonesian Heart Association  2017.4 

(Symposium)Hemodynamic Unloading Reverses Occlusive Vascular Lesions in Severe PAH by inhibiting perivascular inflammation.

2017.3 

Dynamic chest radiography is a novel modality to detect pulmonary perfusion defects in patients with CTEPH

Abe K, Hosokwa K, Yamasaki K.

2024.3 

Lung Uric Acid is a Novel Therapeutic Target for Pulmonary Arterial Hypertension

2022.5 

(Symposium)TLR9による無菌性炎症は肺高血圧症と右室不全の進展に重要な役割を担う Invited

阿部　弘太郎、石川　智一、吉田　賢明、石川　真理子、渡邊　高徳、細川　和也、筒井　裕之

第22回日本心不全学会学術集会  2018.10 

(Symposium)血行動態ストレスと肺血管病変・右心不全進展機序 Invited

阿部　弘太郎、宮里　幸、樋口　妙、永富 祐太、吉田　賢明、石川　智一、渡邊　高徳、肥後　太基、井手　友美、筒井　裕之

第24回日本心臓リハビリテーション学会学術集会  2018.7 

(Symposium)Hemodynamic Unloading Reverses Occlusive Vascular Lesions in Severe PAH by inhibiting perivascular inflammation Invited

2018.3 

(会長特別企画　Symposium)Hemodynamic Stress is Essential to the Development of Occlusive Lesions in PAH Invited

阿部弘太郎

第3回 日本肺高血圧・肺循環学会学術総会  2017.5 

Temporal Changes in Functional Roles of Endogenous Nitric Oxide in a Rat Model of Pulmonary Arterial Hypertension.

2017.3 

Inhibition of TLR9-NF-κB-mediated Inflammation Reverses Fibrosis and Improves Right Ventricular Function in Pulmonary Artery Banding

吉田　賢明, 阿部 弘太郎

2017.3 

Inhibition of Nuclear Factor-kappaB-mediated Inflammation Reverses Fibrosis and Improves Right Ventricular Function in Rats with Pulmonary Artery Banding International conference

Annual Scientific Meeting of the American Heart Association 2016  2016.11 

Specific and Increased Expression of Thrombin Receptor PAR1 in Pulmonary Artery Plays a Key Role in the Pathogenesis of Monocrotaline-induced Pulmonary Hypertension in Rats International conference

Annual Scientific Meeting of the American Heart Association 2016  2016.11 

肺高血圧に対する薬物治療の進歩 Invited

阿部 弘太郎

第20回日本心不全学会学術集会  2016.10 

Upfront治療～基礎と臨床双方の観点から Invited

阿部 弘太郎, 筒井 裕之

第1回日本肺高血圧・肺循環学会学術集会  2016.9 

治療という観点から見た肺高血圧人体病理情報の限界と動物モデルの重要性 Invited

阿部 弘太郎

第1回日本肺高血圧・肺循環学会学術集会  2017.10 

PAHの発症と進展機序 Invited

阿部 弘太郎

第1回日本肺高血圧・肺循環学会学術集会  2016.10 

急速に進歩した肺高血圧症治療のupdate Invited

阿部 弘太郎, 筒井 裕之

第1回日本肺高血圧・肺循環学会学術集会  2016.10 

新規PAHモデルにおける閉塞性肺血管病変進展・維持に関する研究 Invited

阿部 弘太郎, 筒井 裕之

第1回日本肺高血圧・肺循環学会学術集会  2016.9 

末期PAHに特徴的なplexiform病変の解析 Invited

阿部 弘太郎

第1回日本肺高血圧・肺循環学会学術集会  2016.9 

血行動態ストレス軽減を標的としたPAH治療機序の解明 Invited

阿部 弘太郎

第64回日本心臓病学会学術集会  2016.9 

Inhibition of Nuclear Factor-kappaB-mediated Inflammation Improves RV Function in Rats with Pulmonary Artery Banding. International conference

European Society Cardiology Congress 2016  2016.8 

Balloon Pulmonary Angioplasty Improves Right Ventricular-Pulmonary Arterial Coupling and Energetic Efficiency without Changing Right Ventricular Contractility in Patients with Chronic Thromboembolic Pulmonary Hypertension International conference

European Society Cardiology Congress 2016  2016.9 

肺高血圧症患者に対する心リハ時の低酸素状態の検討 Invited

阿部 弘太郎

第22回日本心臓リハビリテーション学会  2016.7 

Protective Role of Endogenous Nitric Oxide in Established Pulmonary Arterial Hypertension. Invited International conference

The 16th Annual Scientific Meeting of the nitric Oxide Society of Japan  2016.5 

Nitric oxide and beyond: new insights and therapies for pulmonary hypertension Invited International conference

The 9th International conference on the Biology, Chemistry, and Therapeutic Applications of nitric Oxide  2016.5 

Hemodynamic Unloading Rapidly Reverses Perivascular Inflammation in a Rat Model of PAH. International conference

American Thoracic Society  2016.5 

American Thoracic Society

American Heart Association

European Society of Cardiology

International Society of Heart Reserch

日本痛風・尿酸核酸学会

Councilor   Domestic

2018.4 - Present   

Councilor   Domestic

2016.4 - 2018.3   

Steering committee member   Domestic

2013.4 - 2019.3   

日本呼吸器学会   肺循環・肺損傷学術部会 将来計画委員   Domestic

2013.4 - 2019.3   

Screening of academic papers

Role(s)： Peer review

2022

座長(Chairmanship)

第85回日本循環器学会総会  2021.3

Screening of academic papers

Role(s)： Peer review

2021

座長(Chairmanship)

第84回日本循環学会総会  2020.3

Screening of academic papers

Role(s)： Peer review

2020

プログラム委員、座長

第4回日本肺循環肺高血圧学会  （ 静岡 ） 2019.6

座長（Chairmanship）

第83回日本循環学会総会  （ 東京 ） 2019.3

Screening of academic papers

Role(s)： Peer review

2019

プログラム委員　座長

第3回日本肺高血圧・肺循環学会学術集会  （ 大阪 ） 2018.6

座長（Chairmanship）

第82回日本循環器学会総会  （ 大阪 ） 2018.3

Screening of academic papers

Role(s)： Peer review

2018

プログラム委員

第2回日本肺循環肺高血圧学会  （ 北海道 ） 2017.6

座長（Chairmanship）

第81回日本循環器学会総会  （ 石川 ） 2017.3

Screening of academic papers

Role(s)： Peer review

2017

プログラム委員

第１回日本肺循環肺高血圧学会  （ 東京 ） 2016.9 - 2017.10

難治性呼吸器疾患・肺高血圧症に関する調査研究

2020 - 2024

科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

レジストリを活用した慢性血栓塞栓性肺高血圧症に対するエドキサバンの適応拡大のための第III相医師主導治験

Grant number：20lk0201125h0001  2020 - 2023

科学研究費助成事業  日本医療研究開発機構　臨床研究・治験推進研究事業

領域別基盤研究分野における難病の医療水準の向上や患者のQOL 向上に資する研究難治性呼吸器疾患・肺高血圧症に関する調査研究

2020 - 2023

科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

難治性心血管疾患におけるマルチオミックス解析による病態解明と精密医療

2020 - 2023

科学研究費助成事業  日本医療研究開発機構　臨床研究・治験推進研究事業

ミトコンドリア分解を起点とした肺高血圧症の病態解明と新規治療法の開発

Grant number：20K08425  2020 - 2022

日本学術振興会  科学研究費助成事業  基盤研究(C)

全国患者レジストリJapan PH Registryのデータを利活用し肺動脈性肺高血圧症に対するPrecision Medicineを実施するためのコンセプト策定研究

2020 - 2022

科学研究費助成事業  日本医療研究開発機構　臨床研究・治験推進研究事業

多施設レジストリを活用し、慢性血栓塞栓性肺高血圧症に対するエドキサバンの適応拡大を目指すコンセプト策定研究

Grant number：19lk0201102h0001  2019 - 2020

科学研究費助成事業  日本医療研究開発機構 臨床研究・治験推進事業

慢性血栓塞栓性肺高血圧症に関する多施設レジストリ構築研究

2018.4 - 2025.3

九州大学病院 

慢性血栓塞栓性肺高血圧症に関する多施設共同レジストリ研究

Grant number：18ek0109371h0001  2018 - 2021

科学研究費助成事業  平成30年度日本医療研究開発機構　難治性疾患実用化研究事業 診療に直結するエビデンス創出研究

産学官連携を加速する肺高血圧症患者レジストリJapan PH Registryの活用研究

Grant number：18lk1601003h0001  2018 - 2020

科学研究費助成事業  平成30年度日本医療研究開発機構　クリニカル・イノベーション・ネットワーク推進支援事業

肺高血圧症の閉塞性病変進展における炎症誘導機構の解明および新規治療法の開発

Grant number：17K09591  2017 - 2020

日本学術振興会  科学研究費助成事業  基盤研究(C)

呼吸不全に関する調査研究

2016 - 2020

科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

疾患予後と医療の質の改善を目的とし多領域横断的な難治性肺高血圧症症例登録研究

2016 - 2018

科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

重症肺高血圧症に対するエビデンスを構築する新規戦略的研究

2015 - 2017

科学研究費助成事業  日本医療研究開発機構研究費　難治性疾患実用化研究事業

肺高血圧症の閉塞性血管病変形成と維持における血行動態ストレスの役割解明

Grant number：26461146  2014 - 2017

日本学術振興会  科学研究費助成事業  基盤研究(C)

成人発症型末梢性肺動脈狭窄症の全国的実態把握と効果的診断治療法の研究

2013 - 2015

科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

新しい肺高血圧症モデルを用いた骨髄由来内皮前駆細胞の病態学的役割の解明

Grant number：24790764  2012 - 2014

科学研究費助成事業  若手研究(B)

肺高血圧症の閉塞性肺血管病変および右心不全進展における血行動態ストレスの役割解明

2010.4

肺動脈性肺高血圧症進展における血管過収縮機序の解明

2010.4

九州大学 

OSCE胸部.

2020.4 - 2020.9   First semester

医学部3年生「循環器内科」肺高血圧症　授業

2019.10 - 2020.3   Second semester

医学部3年生「循環器内科」肺高血圧症　授業

2018.10 - 2019.3   Second semester

2021  Special Affairs 

2020  Class Teacher 

2020  Special Affairs 

2019  Class Teacher 

2019  Special Affairs 

2018  Class Teacher 

2018  Special Affairs