Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance Reviewed

Science   354 ( 6316 )   1156 - 1160   2016.12

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells International journal

Yoshiko Matsumoto Ikushima, Fumio Arai, Kentaro Hosokawa, Hirofumi Toyama, Keiyo Takubo, Tomoyuki Furuyashiki, Shuh Narumiya, Toshio Suda

Blood   121 ( 11 )   1995 - 2007   2013.3

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells Reviewed

Yuka Nakamura, Fumio Arai, Hiroko Iwasaki, Kentaro Hosokawa, Isao Kobayashi, Yumiko Gomei, Yoshiko Matsumoto, Hiroki Yoshihara, Toshio Suda

Blood   116 ( 9 )   1422 - 1432   2010.9

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells Reviewed

Kentaro Hosokawa, Fumio Arai, Hiroki Yoshihara, Hiroko Iwasaki, Yuka Nakamura, Yumiko Gomei, Toshio Suda

Blood   116 ( 4 )   554 - 563   2010.7

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow Reviewed

Kentaro Hosokawa, Fumio Arai, Hiroki Yoshihara, Hiroko Iwasaki, Mark Hembree, Tong Yin, Yuka Nakamura, Yumiko Gomei, Keiyo Takubo, Haruko Shiama, Sahoko Matsuoka, Linheng Li, Toshio Suda

Cell stem cell   6 ( 3 )   194 - 198   2010.3

Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche Reviewed

Hiroki Yoshihara, Fumio Arai, Kentaro Hosokawa, Tetsuya Hagiwara, Keiyo Takubo, Yuka Nakamura, Yumiko Gomei, Hiroko Iwasaki, Sahoko Matsuoka, Kana Miyamoto, Hiroshi Miyazaki, Takao Takahashi, Toshio Suda

Cell stem cell   1 ( 6 )   685 - 697   2007.12

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche Reviewed

Fumio Arai, Atsushi Hirao, Masako Ohmura, Hidetaka Sato, Sahoko Matsuoka, Keiyo Takubo, Keisuke Ito, Gou Young Koh, Toshio Suda

Cell   118 ( 2 )   149 - 161   2004.7

POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis. International journal

Kentaro Nakashima, Yuya Kunisaki, Kentaro Hosokawa, Kazuhito Gotoh, Hisayuki Yao, Ryosuke Yuta, Yuichiro Semba, Jumpei Nogami, Yoshikane Kikushige, Patrick S Stumpf, Ben D MacArthur, Dongchon Kang, Koichi Akashi, Shouichi Ohga, Fumio Arai

Communications biology   6 ( 1 )   996 - 996   2023.9   （ eISSN:2399-3642 ）

MBTD1 preserves adult hematopoietic stem cell pool size and function. International journal

Keiyo Takubo, Phyo Wai Htun, Takeshi Ueda, Yasuyuki Sera, Masayuki Iwasaki, Miho Koizumi, Kohei Shiroshita, Hiroshi Kobayashi, Miho Haraguchi, Shintaro Watanuki, Zen-Ichiro Honda, Norimasa Yamasaki, Ayako Nakamura-Ishizu, Fumio Arai, Noboru Motoyama, Tomohisa Hatta, Tohru Natsume, Toshio Suda, Hiroaki Honda

Proceedings of the National Academy of Sciences of the United States of America   120 ( 32 )   e2206860120   2023.8   （ ISSN:0027-8424 eISSN:1091-6490 ）

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis. International journal

Yaeko Nakajima-Takagi, Motohiko Oshima, Junichiro Takano, Shuhei Koide, Naoki Itokawa, Shun Uemura, Masayuki Yamashita, Shohei Andoh, Kazumasa Aoyama, Yusuke Isshiki, Daisuke Shinoda, Atsunori Saraya, Fumio Arai, Kiyoshi Yamaguchi, Yoichi Furukawa, Haruhiko Koseki, Tomokatsu Ikawa, Atsushi Iwama

eLife   12   2023.6

Generation of functional oocytes from male mice in vitro. International journal

Kenta Murakami, Nobuhiko Hamazaki, Norio Hamada, Go Nagamatsu, Ikuhiro Okamoto, Hiroshi Ohta, Yoshiaki Nosaka, Yukiko Ishikura, Tomoya S Kitajima, Yuichiro Semba, Yuya Kunisaki, Fumio Arai, Koichi Akashi, Mitinori Saitou, Kiyoko Kato, Katsuhiko Hayashi

Nature   615 ( 7954 )   900 - +   2023.3   （ ISSN:0028-0836 eISSN:1476-4687 ）

POT1a IS ESSENTIAL FOR MESENCHYMAL NICHES SUPPORTING B CELL DEVELOPMENT

Nakashima, K; Kunisaki, Y; Hosokawa, K; Yao, H; Yuta, R; Akashi, K; Ohga, S; Arai, F

PEDIATRIC BLOOD & CANCER   69   2022.11   （ ISSN:1545-5009 eISSN:1545-5017 ）

MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis. Reviewed International journal

Yasutaka Hayashi, Kimihito C Kawabata, Yosuke Tanaka, Yasufumi Uehara, Yo Mabuchi, Koichi Murakami, Akira Nishiyama, Shigeru Kiryu, Yusuke Yoshioka, Yasunori Ota, Tatsuki Sugiyama, Keiko Mikami, Moe Tamura, Tsuyoshi Fukushima, Shuhei Asada, Reina Takeda, Yuya Kunisaki, Tomofusa Fukuyama, Kazuaki Yokoyama, Tomoyuki Uchida, Masao Hagihara, Nobuhiro Ohno, Kensuke Usuki, Arinobu Tojo, Yoshio Katayama, Susumu Goyama, Fumio Arai, Tomohiko Tamura, Takashi Nagasawa, Takahiro Ochiya, Daichi Inoue, Toshio Kitamura

Cell reports   39 ( 6 )   110805 - 110805   2022.5   （ ISSN:2211-1247 ）

Hematopoietic Cell Isolation by Antibody-Free Flow Cytometry in the Zebrafish Embryo Reviewed

Katsuhiro Konno, Jingjing Kobayashi-Sun, Fumio Arai, Isao Kobayashi, Daisuke Sugiyama

Methods in molecular biology   2520   171 - 180   2022.5   （ ISSN:1064-3745 ISBN:9781071624364, 9781071624371 eISSN:1940-6029 ）

A novel method to purify neutrophils enables functional analysis of zebrafish hematopoiesis. Reviewed International journal

Katsuhiro Konno, Kasem Kulkeaw, Manabu Sasada, Takenobu Nii, Ayako Kaneyuki, Tohru Ishitani, Fumio Arai, Daisuke Sugiyama

Genes to cells : devoted to molecular & cellular mechanisms   25 ( 12 )   770 - 781   2020.12

Heterogeneity and 'memory' in stem cell populations. Reviewed International journal

Patrick S Stumpf, Fumio Arai, Ben D MacArthur

Physical biology   17 ( 6 )   065013 - 065013   2020.11

Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS

Yasutaka Hayashi, Kimihito Cojin Kawabata, Yosuke Tanaka, Yasufumi Uehara, Shigeru Kiryu, Yasunori Ota, Yusuke Yoshioka, Yo Mabuchi, Tatsuki Sugiyama, Keiko Mikami, Moe Tamura, Tsuyoshi Fukushima, Shuhei Asada, Reina Takeda, Yuya Kunisaki, Tomofusa Fukuyama, Susumu Goyama, Kazuaki Yokoyama, Arinobu Tojo, Yoshio Katayama, Fumio Arai, Takashi Nagasawa, Takahiro Ochiya, Daichi Inoue

BLOOD   136   2020.11

Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45- TER119-Erythroid and Lymphoid Progenitors. Reviewed International journal

Kazuhito Gotoh, Yuya Kunisaki, Soichi Mizuguchi, Daiki Setoyama, Kentaro Hosokawa, Hisayuki Yao, Yuya Nakashima, Mikako Yagi, Takeshi Uchiumi, Yuichiro Semba, Jumpei Nogami, Koichi Akashi, Fumio Arai, Dongchon Kang

iScience   23 ( 11 )   101654 - 101654   2020.11

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis Reviewed

Hiroyasu Kidoya, Fumitaka Muramatsu, Teppei Shimamura, Weizhen Jia, Takashi Satoh, Yumiko Hayashi, Hisamichi Naito, Yuya Kunisaki, Fumio Arai, Masahide Seki, Yutaka Suzuki, Tsuyoshi Osawa, Shizuo Akira, Nobuyuki Takakura

Nature communications   10 ( 1 )   2019.12

概日リズム制御分子を標的とした新規白血病治療薬の開発

國崎 祐哉, 後藤 和人, 廣田 毅, 康 東天, 新井 文用

臨床病理   67 ( 補冊 )   149 - 149   2019.10

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo Reviewed

Hiroshi Kobayashi, Takayuki Morikawa, Ayumi Okinaga, Fumie Hamano, Tomomi Hashidate-Yoshida, Shintaro Watanuki, Daisuke Hishikawa, Hideo Shindou, Fumio Arai, Yasuaki Kabe, Makoto Suematsu, Takao Shimizu, Keiyo Takubo

Cell Reports   28 ( 1 )   145 - 158.e9   2019.7

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth Reviewed

Tsuyoshi Oshima, Yoshimi Niwa, Keiko Kuwata, Ashutosh Srivastava, Tomoko Hyoda, Yoshiki Tsuchiya, Megumi Kumagai, Masato Tsuyuguchi, Teruya Tamaru, Akiko Sugiyama, Natsuko Ono, Norjin Zolboot, Yoshiki Aikawa, Shunsuke Oishi, Atsushi Nonami, Fumio Arai, Shinya Hagihara, Junichiro Yamaguchi, Florence Tama, Yuya Kunisaki, Kazuhiro Yagita, Masaaki Ikeda, Takayoshi Kinoshita, Steve A. Kay, Kenichiro Itami, Tsuyoshi Hirota

Science Advances   5 ( 1 )   eaau9060 - eaau9060   2019.1

The role of telomere binding molecules for normal and abnormal hematopoiesis Reviewed

Kentaro Hosokawa, Fumio Arai

International Journal of Hematology   107 ( 6 )   646 - 655   2018.6

Guest editorial Regulatory signaling in normal and abnormal hematopoiesis Reviewed

Fumio Arai

International Journal of Hematology   1 - 3   2018.5

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress Reviewed

Yuko Tadokoro, Takayuki Hoshii, Satoshi Yamazaki, Koji Eto, Hideo Ema, Masahiko Kobayashi, Masaya Ueno, Kumiko Ohta, Yuriko Arai, Eiji Hara, Kenichi Harada, Masanobu Oshima, Hiroko Oshima, Fumio Arai, Akihiko Yoshimura, Hiromitsu Nakauchi, Atsushi Hirao

Cell Stem Cell   22 ( 5 )   713 - 725.e8   2018.5

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS Reviewed International journal

Takuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Yuichiro Semba, Mohammad Shboul, Mohammed Al-Raqad, Manami Maeda, Vivien A.C. Schoonenberg, Mitchel A. Cole, Claudio Macias-Trevino, Yuichi Ishikawa, Qiuming Yao, Michitaka Nakano, Fumio Arai, Stuart H. Orkin, Bruno Reversade, Silvia Buonamici, Luca Pinello, Koichi Akashi, Daniel E. Bauer, Takahiro Maeda

Cancer Cell   33 ( 3 )   386 - 400.e5   2018.3

Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression Reviewed

Mohamed A.E. Ali, Kyoko Fuse, Yuko Tadokoro, Takayuki Hoshii, Masaya Ueno, Masahiko Kobayashi, Naho Nomura, Ha Thi Vu, Hui Peng, Ahmed M. Hegazy, Masayoshi Masuko, Hirohito Sone, Fumio Arai, Atsushi Tajima, Atsushi Hirao

Scientific Reports   7 ( 1 )   2017.12

Stem Cell Differentiation as a Non-Markov Stochastic Process Reviewed

Cell Systems   5 ( 3 )   268 - 282.e7   2017.9

造血幹細胞の自己複製・分化制御 Reviewed

新井文用

臨床血液   57 ( 10 )   2016.10

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes Reviewed

Shuhei Koide, Motohiko Oshima, Keiyo Takubo, Satoshi Yamazaki, Eriko Nitta, Atsunori Saraya, Kazumasa Aoyama, Yuko Kato, Satoru Miyagi, Yaeko Nakajima-Takagi, Tetsuhiro Chiba, Hirotaka Matsui, Fumio Arai, Yutaka Suzuki, Hiroshi Kimura, Hiromitsu Nakauchi, Toshio Suda, Yoichi Shinkai, Atsushi Iwama

Blood   128 ( 5 )   638 - 649   2016.8

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes Reviewed

Hiroshi Sakamoto, Naoki Takeda, Fumio Arai, Kentaro Hosokawa, Paloma Garcia, Toshio Suda, Jon Frampton, Minetaro Ogawa

Stem Cells   33 ( 2 )   479 - 490   2015.1

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells Reviewed

Masayuki Yamashita, Eriko Nitta, Go Nagamatsu, Yoshiko Matsumoto Ikushima, Kentaro Hosokawa, Fumio Arai, Toshio Suda

Biochemical and Biophysical Research Communications   441 ( 1 )   196 - 201   2013.11

OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets Reviewed

Yumiko Matsubara, Yukako Ono, Hidenori Suzuki, Fumio Arai, Toshio Suda, Mitsuru Murata, Yasuo Ikeda

PLoS One   8 ( 3 )   2013.3

Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells Reviewed

Yoshiko Matsumoto Ikushima, Fumio Arai, Yuka Nakamura, Kentaro Hosokawa, Yoshiaki Kubota, Masanori Hirashima, Hirofumi Toyama, Toshio Suda

Biochemical and Biophysical Research Communications   430 ( 1 )   20 - 25   2013.1

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs Reviewed

Hirofumi Toyama, Fumio Arai, Kentaro Hosokawa, Yoshiko Matsumoto Ikushima, Toshio Suda

Biochemical and Biophysical Research Communications   428 ( 3 )   354 - 359   2012.11

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance Reviewed

18 ( 9 )   1350 - 1358   2012.9

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Fumio Arai, Kentaro Hosokawa, Hirofumi Toyama, Yoshiko Matsumoto, Toshio Suda

Annals of the New York Academy of Sciences   1266 ( 1 )   72 - 77   2012.8

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche Reviewed

Ryohichi Sugimura, Xi C. He, Aparna Venkatraman, Fumio Arai, Andrew Box, Craig Semerad, Jeffrey S. Haug, Lai Peng, Xiao Bo Zhong, Toshio Suda, Linheng Li

Cell   150 ( 2 )   351 - 365   2012.7

Gene expression profiling and regulatory networks in single cells

Fumio Arai, Kentaro Hosokawa, Yoshiko Matsumoto, Hirofumi Toyama, Toshio Suda

New Frontiers of Network Analysis in Systems Biology   1 - 13   2012.2

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation Reviewed

Blood   118 ( 13 )   3613 - 3621   2011.9

Telomerase reverse transcriptase protectsATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism Reviewed

Eriko Nitta, Masayuki Yamashita, Kentaro Hosokawa, Ming Ji Xian, Keiyo Takubo, Fumio Arai, Shinichiro Nakada, Toshio Suda

Blood   117 ( 16 )   4169 - 4180   2011.4

Acquisition of G₀ state by CD34-positive cord blood cells after bone marrow transplantation Reviewed

Haruko Shima, Keiyo Takubo, Naoko Tago, Hiroko Iwasaki, Fumio Arai, Takao Takahashi, Toshio Suda

Experimental Hematology   38 ( 12 )   1231 - 1240   2010.12

TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool Reviewed

Hideaki Nakajima, Miyuki Ito, David S. Smookler, Fumi Shibata, Yumi Fukuchi, Yoshihiro Morikawa, Yuichi Ikeda, Fumio Arai, Toshio Suda, Rama Khokha, Toshio Kitamura

Blood   116 ( 22 )   4474 - 4482   2010.11

Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver Reviewed

Hiroko Iwasaki, Fumio Arai, Yoshiaki Kubota, Maria Dahl, Toshio Suda

Blood   116 ( 4 )   544 - 553   2010.7

Erratum Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (Nature Medicine (2006)12 (446-451)) Reviewed

Keisuke Ito, Atsushi Hirao, Fumio Arai, Keiyo Takubo, Sahoko Matsuoka, Kana Miyamoto, Masako Ohmura, Kazuhito Naka, Kentaro Hosokawa, Yasuo Ikeda, Toshio Suda

Nature medicine   16 ( 1 )   2010.1

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells Reviewed

Yumiko Gomei, Yuka Nakamura, Hiroki Yoshihara, Kentaro Hosokawa, Hiroko Iwasaki, Toshio Suda, Fumio Arai

Experimental Hematology   38 ( 2 )   2010.1

Niche Regulation of Hematopoietic Stem Cells in the Endosteum

Fumio Arai, Hiroki Yoshihara, Kentaro Hosokawa, Yuka Nakamura, Yumiko Gomei, Hiroko Iwasaki, Toshio Suda

Annals of the New York Academy of Sciences   1176 ( 1 )   36 - 46   2009.9

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion

15 ( 6 )   696 - 700   2009.6

Angiopoietins contribute to lung development by regulating pulmonary vascular network formation Reviewed

Tai Hato, Yoshishige Kimura, Tohru Morisada, Gou Young Koh, Keishi Miyata, Mitsuhisa Tabata, Tsuyoshi Kadomatsu, Motoyoshi Endo, Takashi Urano, Fumio Arai, Kimi Araki, Toshio Suda, Koichi Kobayashi, Yuichi Oike

Biochemical and Biophysical Research Communications   381 ( 2 )   218 - 223   2009.4

Niche regulation of hematopoietic stem cells in the endosteum The role of thrombopoietinmpl signaling in the maintenance of quiescent Hematopoietic Stem Cells

Fumio Arai, Hiroki Yoshihara, Kentaro Hosokawa, Yuka Nakamura, Yumiko Gomei, Hiroko Iwasaki, Toshio Suda

Hematopoietic Stem Cells VII   36 - 46   2009.1

Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice Reviewed

Haruko Shima, Keiyo Takubo, Hiroko Iwasaki, Hiroki Yoshihara, Yumiko Gomei, Kentaro Hosokawa, Fumio Arai, Takao Takahashi, Toshio Suda

Biochemical and Biophysical Research Communications   378 ( 3 )   467 - 472   2009.1

Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity Reviewed

Masako Ohmura, Kazuhito Naka, Takayuki Hoshii, Teruyuki Muraguchi, Haruhiko Shugo, Akira Tamase, Noriyuki Uema, Takako Ooshio, Fumio Arai, Keiyo Takubo, Go Nagamatsu, Isao Hamaguchi, Minoru Takagi, Masahiko Ishihara, Kazuhiro Sakurada, Hiromasa Miyaji, Toshio Suda, Atsushi Hirao

STEM CELLS   26 ( 12 )   3237 - 3246   2008.12

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL Reviewed

Sahoko Matsuoka, Yuichi Oike, Ichiro Onoyama, Atsushi Iwama, Fumio Arai, Keiyo Takubo, Yoichi Mashimo, Hideyuki Oguro, Eriko Nitta, Keisuke Ito, Kana Miyamoto, Hiroki Yoshiwara, Kentaro Hosokawa, Yuka Nakamura, Yumiko Gomei, Hiroko Iwasaki, Yasuhide Hayashi, Yumi Matsuzaki, Keiko Nakayama, Yasuo Ikeda, Akira Hata, Shigeru Chiba, Keiichi I. Nakayama, Toshio Suda

Genes and Development   22 ( 8 )   986 - 991   2008.4

Wnt Signaling in the Niche Reviewed

Toshio Suda, Fumio Arai

Cell   132 ( 5 )   729 - 730   2008.3

Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest Reviewed

Keiyo Takubo, Masako Ohmura, Masaki Azuma, Go Nagamatsu, Wakako Yamada, Fumio Arai, Atsushi Hirao, Toshio Suda

Cell stem cell   2 ( 2 )   170 - 182   2008.2

Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction Reviewed

Kentaro Hosokawa, Fumio Arai, Hiroki Yoshihara, Yuka Nakamura, Yumiko Gomei, Hiroko Iwasaki, Kana Miyamoto, Haruko Shima, Keisuke Ito, Toshio Suda

Biochemical and Biophysical Research Communications   363 ( 3 )   578 - 583   2007.11

Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool Reviewed

Kana Miyamoto, Kiyomi Y. Araki, Kazuhito Naka, Fumio Arai, Keiyo Takubo, Satoshi Yamazaki, Sahoko Matsuoka, Takeshi Miyamoto, Keisuke Ito, Masako Ohmura, Chen Chen, Kentaro Hosokawa, Hiromitsu Nakauchi, Keiko Nakayama, Keiichi I. Nakayama, Mine Harada, Noboru Motoyama, Toshio Suda, Atsushi Hirao

Cell stem cell   1 ( 1 )   101 - 112   2007.6

Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche

Fumio Arai, Toshio Suda

Hematopoietic Stem Cells VI   41 - 53   2007.6

Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice Reviewed

M. Ninomiya, A. Abe, A. Katsumi, J. Xu, M. Ito, F. Arai, T. Suda, M. Ito, H. Kiyoi, T. Kinoshita, T. Naoe

Leukemia   21 ( 1 )   136 - 142   2007.4

精子形成におけるNucleosteminの役割

大村 昌子, 仲 一仁, 吉田 松生, 新井 文用, 木下 雅史, 玉瀬 玲, 田久保 圭誉, 澤田 元, 須田 年生, 平尾 敦

解剖学雑誌   82 ( Suppl. )   249 - 249   2007.3

Role of Stem Cell Niche in the Maintenance of Hematopoietic Stem Cells

Arai Fumio, Suda Toshio

27 ( 2 )   117 - 123   2007.3

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes Reviewed

Keisuke Ito, Keiyo Takubo, Fumio Arai, Hitoshi Satoh, Sahoko Matsuoka, Masako Ohmura, Kazuhito Naka, Masaki Azuma, Kana Miyamoto, Kentaro Hosokawa, Yasuo Ikeda, Tak W. Mak, Toshio Suda, Atsushi Hirao

Journal of Immunology   178 ( 1 )   103 - 110   2007.1

Premeiotic germ cell defect in seminiferous tubules of Atm-null testis Reviewed

Keiyo Takubo, Atsushi Hirao, Masako Ohmura, Masaki Azuma, Fumio Arai, Go Nagamatsu, Toshio Suda

Biochemical and Biophysical Research Communications   351 ( 4 )   993 - 998   2006.12

組織幹細胞マーキング法の開発

大村 昌子, 仲 一仁, 新井 文用, 木下 雅史, 玉瀬 玲, 松岡 佐保子, 伊藤 圭介, 宮本 佳奈, 田久保 圭誉, 須田 年生, 平尾 敦

臨床血液   47 ( 9 )   1036 - 1036   2006.9

造血ニッチによる幹細胞制御 Reviewed

新井文用

臨床血液   47 ( 5 )   2006.5

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells Reviewed

Keisuke Ito, Atsushi Hirao, Fumio Arai, Keiyo Takubo, Sahoko Matsuoka, Kana Miyamoto, Masako Ohmura, Kazuhito Naka, Kentaro Hosokawa, Yasuo Ikeda, Toshio Suda

Nature medicine   12 ( 4 )   446 - 451   2006.4

Regulation of Hematopoietic Stem Cells and Interactions with Stem Cell Niche

ARAI Fumio

Journal of oral biosciences   48 ( 1 )   22 - 29   2006.2

Regulation of Hematopoiesis and Its Interaction with Stem Cell Niches

Fumio Arai, Atsushi Hirao, Toshio Suda

International Journal of Hematology   82 ( 5 )   371 - 376   2005.12

Regulation of stem cells in the niche Reviewed

Toshio Suda, Fumio Arai, Shigeto Shimmura

Cornea   24 ( 8 SUPPL. )   S12 - S17   2005.11

Hematopoietic stem cells and their niche Reviewed

Toshio Suda, Fumio Arai, Atsushi Hirao

Trends in Immunology   26 ( 8 )   426 - 433   2005.8

Regulation of hematopoiesis by the osteoblastic niche Reviewed

Arai, F.

Clinical calcium   15 ( 7 )   2005.8

Regulation of self-renewal of hematopoietic stem cells in the niche Reviewed

Hirao, A., Arai, F., Ito, K., Suda, T.

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   50 ( 7 )   2005.6

Regulation of hematopoietic stem cells by the niche Reviewed

Fumio Arai, Atsushi Hirao, Toshio Suda

Trends in Cardiovascular Medicine   15 ( 2 )   75 - 79   2005.1

Regulation of cell cycle in hematopoietic stem cells by the niche Reviewed

Atsushi Hirao, Fumio Arai, Toshio Suda

Cell Cycle   3 ( 12 )   1481 - 1483   2004.12

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells Reviewed

Keisuke Ito, Atsushi Hirao, Fumio Arai, Sahoko Matsuoka, Keiyo Takubo, Isao Hamaguchi, Kana Nomiyama, Kentaro Hosokawa, Kazuhiro Sakurada, Naomi Nakagata, Yasuo Ikeda, Tak W. Mak, Toshio Suda

Nature   431 ( 7011 )   997 - 1002   2004.10

Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration

Y. Oike, K. Yasunaga, Y. Ito, S.-i. Matsumoto, H. Maekawa, T. Morisada, F. Arai, N. Nakagata, M. Takeya, Y. Masuho, T. Suda

Proceedings of the National Academy of Sciences   100 ( 16 )   9494 - 9499   2003.8

Mast cell-released novel angiopoietin-related growth factor (AGF) promotes angiogenesis and epidermal proliferation Reviewed

Y Oike, Y Ito, K Yasunaga, S Matsumoto, H Maekawa, F Arai, K Hamada, K Miyata, Y Masuho, T Suda

CIRCULATION   106 ( 19 )   276 - 277   2002.11

Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells Reviewed

Yuichi Oike, Yasuhiro Ito, Koichi Hamada, Xiu Qin Zhang, Keishi Miyata, Fumio Arai, Tomohisa Inada, Kimi Araki, Naomi Nakagata, Motohiro Takeya, Yaz Y. Kisanuki, Masashi Yanagisawa, Nicholas W. Gale, Toshio Suda

Blood   100 ( 4 )   1326 - 1333   2002.8

Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation Reviewed

Fumio Arai, Osamu Ohneda, Takeshi Miyamoto, Xiu Qin Zhang, Toshio Suda

Journal of Experimental Medicine   195 ( 12 )   1549 - 1563   2002.6

Bifurcation of osteoclasts and dendritic cells from common progenitors Reviewed

Takeshi Miyamoto, Osamu Ohneda, Fumio Arai, Katsuya Iwamoto, Seiji Okada, Katsumasa Takagi, Dirk M. Anderson, Toshio Suda

Blood   98 ( 8 )   2544 - 2554   2001.10

ALCAM (CD166) Its role in hematopoietic and endothelial development Reviewed

Osamu Ohneda, Kinuko Ohneda, Fumio Arai, James Lee, Takeshi Miyamoto, Yoshimi Fukushima, Donald Dowbenko, Laurence A. Lasky, Toshio Suda

Blood   98 ( 7 )   2134 - 2142   2001.10

An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor KB ligand Reviewed

Takeshi Miyamoto, Fumio Arai, Osamu Ohneda, Katsumasa Takagi, Dirk M. Anderson, Toshio Suda

Blood   96 ( 13 )   4335 - 4343   2000.12

WECHE: A novel hematopoietic regulatory factor Reviewed

Osamu Ohneda, Kinuko Ohneda, Hisayuki Nomiyama, Zhong Zheng, Steven A. Gold, Fumio Arai, Takeshi Miyamoto, Bruce E. Taillon, Richard A. McIndoe, Richard A. Shimkets, David A. Lewin, Toshio Suda, Laurence A. Lasky

Immunity   12 ( 2 )   141 - 150   2000.2

WECHE A novel hematopoietic regulatory factor Reviewed

Osamu Ohneda, Kinuko Ohneda, Hisayuki Nomiyama, Zhong Zheng, Steven A. Gold, Fumio Arai, Takeshi Miyamoto, Bruce E. Taillon, Richard A. McIndoe, Richard A. Shimkets, David A. Lewin, Toshio Suda, Laurence A. Lasky

Journal of Cultural Heritage   1 ( 2 )   141 - 150   2000.1

Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor κB (RANK) receptors Reviewed

190 ( 12 )   1741 - 1754   1999.12

Macrophage-stimulating protein (MSP) and its receptor, RON, stimulate human osteoclast activity but not proliferation: Effect of MSP distinct from that of hepatocyte growth factor Reviewed

N. Kurihara, J. Tatsumi, F. Arai, A. Iwama, T. Suda

Experimental Hematology   26 ( 11 )   1080 - 1085   1998.10

23(S)25(R)-1,25-Dihydroxyvitamin D_3-lactone, a naturally occurring metabolite of1,25-dihydroxyvitamin D_3, inhibits osteoclast-like cell formation in human bone marrow cultures Reviewed

KURIHARA Noriyoshi, ISHIZUKA Seiichi, TATSUMI Junichi, ARAI Fumio, IKEDA Katsumi, ROODMAN G. David

Journal of bone and mineral metabolism   16 ( 1 )   5 - 10   1998.8

The N-terminal fragment of osteocalcin is released during osteoclastic bone resorption in vitro Reviewed

KURIHARA Noriyoshi, HOSODA Kenji, TATSUMI Junichi, YAMAJI Teizo, HOSHIHARA Eiyoshi, ARAI Fumio, IKEDA Katsumi

Journal of bone and mineral metabolism   16 ( 1 )   11 - 16   1998.8

Regulation of hematopoietic stem cells in the niche Invited International conference

Arai, Fumio

Hematopoietic Stem Cells VII.  2011.9 

Maintenance of stem cells in the niche Invited International conference

Arai, Fumio

International Conference and Workshop. Hematopoietic Stem Cells VI.  2006.9 

Regulation of hematopoietic stem cell and its interaction with stem cell niche. Invited International conference

Arai, Fumio

Hiroshima conference on education and science in dentistry  2006.1 

幹細胞のニッチ制御 Invited

新井文用

第7回日本再生医療学会総会 

Hematopoietic stem cells and their niche. Invited International conference

Arai, Fumio, Ito, Keisuke, Suda, Toshio

The International Society on Thrombosis & Haemostasis 20th Congress. 

Regulation of hematopoietic stem cells in the osteoblastic niche Invited International conference

Arai, Fumio

1st International Conference on Osteoimmunology: Interaction of the Immune and Skeletal Systems. 

Regulation of the hematopoietic stem cell and its interaction with the osteoblastic niche Invited International conference

Arai, Fumio

Gordon Research Conference, Bone & Teeth 

Niche regulation of hematopoietic stem cells in the endosteum Invited International conference

Arai, Fumio

International Conference and Workshop. Hematopoietic Stem Cells VII. 

Hematopoietic Stem Cell Niche in Bone Marrow Invited

Arai, Fumio

2nd Annual Congress of Regenerative Medicine & Stem Cell at CMBF 2009 

Hematopoietic Stem Cells in the Niche Invited International conference

Arai, Fumio

2009 World Stem Cell Summit 

Regulation of Hematopoietic Stem Cells in the Niche Invited International conference

Arai, Fumio

International Society of Inflammation and Regeneration  2011.6 

Hematopoietic stem cells and their niche. Invited International conference

Arai, Fumio, Ito, Keisuke, Suda, Toshio

The International Society on Thrombosis & Haemostasis 20th Congress. 

幹細胞のニッチ制御 Invited

新井文用

第7回日本再生医療学会総会 

Regulation of the hematopoietic stem cell and its interaction with the osteoblastic niche Invited International conference

Arai, Fumio

Gordon Research Conference, Bone & Teeth 

Regulation of hematopoietic stem cells in the osteoblastic niche Invited International conference

Arai, Fumio

1st International Conference on Osteoimmunology: Interaction of the Immune and Skeletal Systems. 

Niche regulation of hematopoietic stem cells in the endosteum Invited International conference

Arai, Fumio

International Conference and Workshop. Hematopoietic Stem Cells VII. 

Hematopoietic Stem Cells in the Niche Invited International conference

Arai, Fumio

2009 World Stem Cell Summit 

間葉系幹細胞におけるテロメア保護因子Pot1aは、B細胞分化に重要である(POT1a is essential for mesenchymal niches supporting B cell development)

Nakashima Kentaro, Kunisaki Yuya, Hosokawa Kentaro, Yao Hisayuki, Yuta Ryosuke, Akashi Koichi, Ohga Shouichi, Arai Fumio

日本小児血液・がん学会雑誌  2022.10  (一社)日本小児血液・がん学会

白血病幹細胞の維持と白血病細胞の増殖における骨髄ニッチの役割(The role of the bone marrow niche in leukemic stem cell maintenance and leukemic cell progression)

Nguyen Ngan, Yao Hisayuki, Hosokawa Kentaro, Yuta Ryosuke, Esaki Yuki, Arai Fumio

日本血液学会学術集会  2023.10  (一社)日本血液学会

PROTECTION OF TELOMERES 1 (POT1) REGULATES HEMATOPOIETIC STEM CELL ACTIVITY DURING AGEING

Kentaro Hosokawa, Ben D. MacArthur, Shigemasa Hanazawa, Toshio Suda, Fumio Arai

EXPERIMENTAL HEMATOLOGY   2015.9

造血ニッチ分子研究の現状と展望

新井 文用

血液内科   2015.2

POT1 REGULATES SELF-RENEWAL ACTIVITY OF CORD BLOOD HEMATOPOIETIC STEM CELLS

Kentaro Hosokawa, Yoshiko Ikushima, Benjamin MacArthur, Toshio Suda, Fumio Arai

EXPERIMENTAL HEMATOLOGY   2014.8

造血幹細胞・白血病幹細胞とニッチ制御 (第1土曜特集 癌幹細胞) -- (造血系癌幹細胞)

新井 文用

医学のあゆみ   2014.7

トップランナーに聞く : 最先端の医療に挑む若手研究者への直撃インタビュー(40)細胞の対称・非対称分裂制御による造血幹細胞の増幅

新井 文用

最新医学   2014.4

SHELTERIN COMPONENT PROTECTION OF TELOMERES 1 (POT1) PLAYS A CRITICAL ROLE IN THE SELF-RENEWAL OF HSCS

Kentaro Hosokawa, Toshio Suda, Fumio Arai

EXPERIMENTAL HEMATOLOGY   2013.8

A PML-PPAR-delta Pathway for Fatty Acid Oxidation Regulates Hematopoietic Stem Cell Maintenance Through the Control of Asymmetric Division.

Keisuke Ito, Arkaitz Carracedo, Fumio Arai, Ugo Ala, David Avigan, Zachary Schafer, Ron M. Evans, Toshio Suda, Chih-Hao Lee, Pier Paolo Pandolfi

BLOOD   2012.11

FUNCTIONAL ANALYSIS OF POT1 IN THE MAINTENANCE OF HEMATOPOIETIC STEM CELLS

Kentaro Hosokawa, Fumio Arai, Yumiko Nojima, Toshio Suda

EXPERIMENTAL HEMATOLOGY   2012.8

Prostaglandin E2 Signaling Through the EP4 Receptor Regulates the Proliferation of Hematopoietic Stem/Progenitor Cells Under Stress Conditions

Fumio Arai, Yoshiko Matsumoto, Toshio Suda

BLOOD   2011.11

Role of Protection of Telomeres 1A (Pot1a) In the Regulation of Hematopoietic Stem Cells

Fumio Arai, Kentaro Hosokawa, Yumiko Nojima, Toshio Suda

BLOOD   2010.11

境界領域 知っておきたい 造血幹細胞ニッチと骨芽細胞

新井 文用

臨床整形外科   2010.5

造血幹細胞とニッチ制御 : 最近の展開

新井 文用

血液・腫瘍科   2010.3

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (vol 12, pg 446, 2006)

Keisuke Ito, Atsushi Hirao, Fumio Arai, Keiyo Takubo, Sahoko Matsuoka, Kana Miyamoto, Masako Ohmura, Kazuhito Naka, Kentaro Hosokawa, Yasuo Ikeda, Toshio Suda

NATURE MEDICINE   2010.1

Fractionated Osteoblastic Niche Cells Enhances the Homing Activity of Hematopoietic Stem Cells

Fumio Arai, Yuka Nakamura, Kentaro Hosokawa, Isao Kobayashi, Hiroko Iwasaki, Yumiko Gomei, Hiroki Yoshihara, Toshio Suda

BLOOD   2009.11

トロンボポエチントランスジェニックマウスモデルを用いた骨髄線維症の発症機構の解析

咸 明姫, 久保田 義顕, 田久保 圭誉, 鄒 鵬, 中村 由香, 吉原 宏樹, 細川 健太郎, 五明 由美子, 新井 文用, 須田 年生

臨床血液   2009.9

幹細胞ニッチ (第5土曜特集 細胞医療Update) -- (幹細胞の基礎研究)

新井 文用

医学のあゆみ   2009.5

幹細胞ニッチにおけるWntシグナルの意義

新井 文用

血液・腫瘍科   2008.12

Functional Difference of Two Tie2 Ligands, Angiopoietin-1 and-2, in the Regulation of the Adult Bone Marrow Hematopoietic Stem Cells

Yumiko Gomei, Fumio Arai, Hiroki Yoshihara, Hiroko Iwasaki, Kentaro Hosokawa, Yuka Nakamura, Toshio Suda

BLOOD   2008.11

Control of the HSC Niche Signaling for the Efficient Long-Term Engraftment of Hematopoietic Stem Cells without Irradiation or High-Dose Chemotherapy.

Hiroki Yoshihara, Fumio Arai, Kentaro Hosokawa, Takao Takahashi, Hiroshi Miyazaki, Toshio Suda

BLOOD   2008.11

造血幹細胞の内骨膜ニッチ (特集 ベールを脱ぐニッチ--見えてきた幹細胞の居場所)

新井 文用

細胞工学   2008.7

Role of cyclin-dependent kinase inhibitor p57(kip2) in the regulation of hematopoietic stem cell quiescence

Hiroki Yoshihara, Peng Zou, Fumio Arai, Kentaro Hosokawa, Keiyo Takubo, Takao Takahashi, Toshio Suda

EXPERIMENTAL HEMATOLOGY   2008.7

幹細胞のニッチ制御とがん幹細胞 (特集 がん幹細胞研究の進展)

新井 文用

血液・腫瘍科   2008.6

造血幹細胞のニッチ制御 (特集 造血細胞におけるシグナル伝達)

新井 文用

細胞   2007.11

Expression of endothelial protein C receptor confines hematopoietic stem cell in murine fetal liver

Hiroko Iwasaki, Fumio Arai, Yoshiaki Kubota, Toshio Suda

BLOOD   2007.11

HIF-1αを介した骨髄低酸素環境における造血幹細胞の静止期維持

田久保 圭誉, 平尾 敦, 合田 亘人, 新井 文用, 細川 健太郎, 吉原 宏樹, Johnson Randall, 末松 誠, 須田 年生

臨床血液   2007.9

造血幹細胞と骨芽細胞ニッチ (あゆみ 幹細胞とニッチ)

新井 文用, 須田 年生

医学のあゆみ   2007.5

造血幹細胞とニッチ

新井 文用, 須田 年生

生体の科学   2007.5

Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche Reviewed

Fumio Arai, Toshio Suda

Annals of the New York Academy of Sciences   2007.4

Ubiquitin ligase component fbw7 regulates the quiescence of hematopoietic stem cells.

Sahoko Matsuoka, Yuichi Oike, Ichiro Onoyama, Keiyo Takubo, Keisuke Ito, Fumio Arai, Yasuo Ikeda, Keiko Nakayama, Keiichi Nakayama, Toshio Suda

BLOOD   2006.11

Anti-oxidant NAC prevents hypersensitivity, immunodeficiency and lymphomagenesis in Atm(-/-) mice.

Keisuke Ito, Fumio Arai, Sahoko Matsuoka, Yasuo Ikeda, Toshio Suda, Atsushi Hirao

BLOOD   2006.11

Foxo3a is essential for the quiescence and self-renewal of hematopoietic stem cells.

Kana Miyamoto, Atsushi Hirao, Kiyomi Y. Araki, Fumio Arai, Kazuhito Naka, Keiyo Takubo, Sahoko Matsuoka, Satoshi Yamazaki, Keisuke Ito, Masako Ohmura, Kentaro Hosokawa, Mine Harada, Noboru Motoyama, Toshio Suda

BLOOD   2006.11

Reactive oxygen species control hematopoietic stem cell-niche interaction through the regulation of N-cadherin.

Kentaro Hosokawa, Fumio Arai, Hiroki Yoshihara, Keiyo Takubo, Keisuke Ito, Sahoko Matsuoka, Toshio Suda

BLOOD   2006.11

Thrombopoietin-MpI signal induces hematopoietic stem cells into quiescent state in the bone marrow niche.

Hiroki Yoshihara, Fumio Arai, Kentaro Hosokawa, Takao Takahashi, Hiroshi Miyazaki, Toshio Suda

BLOOD   2006.11

骨髄低酸素ニッチにおけるHIF-1αを介した静止期造血幹細胞の制御機構

田久保 圭誉, 平尾 敦, 合田 亘人, 新井 文用, Randall Johnson, 末松 誠, 須田 年生

臨床血液   2006.9

ユビキチンリガーゼコンポーネントFbw7は造血幹細胞の静止状態を制御する

松岡 佐保子, 尾池 雄一, 小野山 一郎, 田久保 圭誉, 伊藤 圭介, 新井 文用, 岩間 厚志, 池田 康夫, 中山 啓子, 中山 敬一, 須田 年生

臨床血液   2006.9

活性酸素種(ROS)の接着制御による造血幹細胞のニッチからの離脱機構の解析

細川 健太郎, 新井 文用, 伊藤 圭介, 田久保 圭誉, 吉原 宏樹, 松岡 佐保子, 須田 年生

臨床血液   2006.9

転写因子FOXO3a欠損による造血幹細胞の自己複製能の低下

宮本 佳奈, 平尾 敦, 新井 文用, 松岡 佐保子, 伊藤 圭介, 田久保 圭誉, 仲 一仁, 大村 昌子, 細川 健太郎, 原田 実根, 本山 昇, 須田 年生

臨床血液   2006.9

Rb plays an essential role in erythroid differentiation through inhibition of apoptosis mediated by NFKB.

S Matsuoka, A Hirao, F Arai, K Takubo, K Miyamoto, K Hosokawa, T Suda

BLOOD   2005.11

Inactivation of p38 MAPK extends self-renewal capacity of haematopoietic stem

K Ito, A Hirao, F Arai, S Matsuoka, K Takubo, Y Ikeda, T Suda

BLOOD   2005.11

Special Review ニッチにある造血幹細胞とその細胞周期制御

須田 年生, 新井 文用

細胞工学   2005.10

酸化ストレスによるp38MAPKを介した造血幹細胞枯渇誘導

伊藤 圭介, 田久保 圭誉, 新井 文用, 松岡 佐保子, 須田 年生, 平尾 敦

日本血液学会・日本臨床血液学会総会プログラム・抄録集   2005.9

造血幹細胞のニッチと自己複製制御機構

平尾 敦, 新井 文用, 伊藤 圭介

蛋白質核酸酵素   2005.6

2等賞 ニッチにおける静止期造血幹細胞の制御 (ベルツ賞 2004年度受賞論文抄録紹介)

須田 年生, 新井 文用, 平尾 敦

日本医師会雑誌   2005.3

特報 第41回ベルツ賞受賞論文:ニッチにおける静止期造血幹細胞の制御

須田 年生, 新井 文用, 平尾 敦

最新医学   2005.2

造血幹細胞の微小環境｢ニッチ｣

新井 文用, 平尾 敦, 須田 年生

生物物理化学 = Journal of Electrophoresis   2004.12

Role of cell adhesion in the maintenance of hematopoietic stem cells in the bone marrow niche.

F Arai, A Hirao, K Hosokawa, T Suda

BLOOD   2004.11

Identification of non-hematopoietic stem cells in mouse bone marrow osteoblastic zone.

H Sato, F Arai, M Shibata, A Hirao, T Suda, K Sakurada

BLOOD   2004.11

Rb regulates erythroid differentiation through Bcl-XL-dependent anti-apoptotic effect.

S Matsuoka, A Hirao, F Arai, K Ito, K Takubo, K Nomiyama, Hamaguchi, I, Y Ikeda, T Suda

BLOOD   2004.11

Regulation of oxidative stress by ATM is required for the self-renewal of haematopoietic stem cells

K Ito, A Hirao, F Arai, S Matsuoka, TW Mak, T Suda

BLOOD   2004.11

幹細胞とそのニッチ(微小環境)について

須田 年生, 宮本 健史, 新井 文用, 平尾 敦

日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association   2004.9

ATM(Ataxia telangiectasia mutated)の造血幹細胞の再構築能における役割 レドックスと自己複製

伊藤 圭介, 平尾 敦, 新井 文用, 松岡 佐保子, 田久保 圭誉, 須田 年生

日本血液学会・日本臨床血液学会総会プログラム・抄録集   2004.9

Rb欠損にみられる赤血球分化異常は,Bcl-XLによって回復する

松岡 佐保子, 平尾 敦, 新井 文用, 濱口 功, 伊藤 圭介, 田久保 圭誉, 野見山 佳奈, 池田 康夫, 須田 年生

日本血液学会・日本臨床血液学会総会プログラム・抄録集   2004.9

Tie2/angiopoietin-1 regulates quiescence of hematopoietic stem cells in a niche.

A Hirao, F Arai, T Suda

BLOOD   2003.11

Identification of quiescent hematopoietic stem cells in side population

A Hirao, F Arai, T Suda

EXPERIMENTAL HEMATOLOGY   2003.7

Ang1/Tie2 signaling regulates quiescence of hematopoietic stem cell in niche

F Arai, A Hirao, T Suda

EXPERIMENTAL HEMATOLOGY   2003.7

Role of EphB4 in the vasculogenesis in bone development

XQ Zhang, N Takakura, F Arai, T Miyamoto, H Sokamoto, T Suda

BLOOD   2001.11

Ephrin-Eph signaling between endothelial cells and surrounding mesenchymal cells plays an essential role in vasculo-angiogenesis

Y Oike, XQ Zhang, Y Ito, K Hamada, K Miyata, F Arai, S Suenobu, N Takakura, T Suda

CIRCULATION   2000.10

European Hematology Association

The Japanese Society of Hematology

Stem Cell Research Symposium

International Society for Stem Cell Research

International Society for Experimental Hematology

American Society of Hematology

シェルタリン因子による造血微小環境（ニッチ）の機能制御メカニズムの解明

Grant number：20H03711  2020 - 2023

日本学術振興会  科学研究費助成事業  基盤研究(B)

シェルタリン因子による造血微小環境（ニッチ）の機能制御メカニズムの解明

Grant number：20H03711  2020 - 2022

日本学術振興会  科学研究費助成事業  基盤研究(B)

老化ニッチによる造血幹細胞の分裂制御異常の分子機構

2020

上原記念生命科学財団研究助成金

シェルタリン因子を用いた造血幹細胞の機能再生と増幅系の確立

2019 - 2021

再生医療実現拠点ネットワークプログラム技術開発個別課題

白血病幹細胞におけるシェルタリン因子TIN2の機能解明と新規治療法開発への応用

Grant number：19K22638  2019 - 2020

日本学術振興会  科学研究費助成事業  挑戦的研究（萌芽）

次世代型人工ニッチを用いた造血幹細胞の非対称分裂制御機構の解明と体外増幅

Grant number：17H04208  2017 - 2019

日本学術振興会  科学研究費助成事業  基盤研究(B)

造血幹細胞の未分化性維持に対する転写因子Foxp2の機能解析

Grant number：17K09907  2017 - 2019

日本学術振興会  科学研究費助成事業  基盤研究(C)

幹細胞の非対称分裂を規定する微小環境(ニッチ)シグナル経路の解明

2017 - 2018

武田科学振興財団生命科学研究助成

造血幹細胞の非対称分裂機構の解明 International coauthorship

2014.4

九州大学大学院医学研究院(日本) 

テロメアDNA損傷回避による造血幹細胞の老化抑制と体外増幅

Grant number：26293228  2014 - 2016

日本学術振興会  科学研究費助成事業  基盤研究(B)

造血幹細胞の対称性分裂制御子の機能解析と細胞分裂操作への応用

Grant number：26670471  2014 - 2015

科学研究費助成事業  挑戦的萌芽研究

細胞分裂制御(対称・非対称分裂)の操作による造血幹細胞増幅

2010 - 2013

最先端・次世代研究開発支援プログラム

人工幹細胞ニッチ:造血ニッチ複合体の再構成による幹細胞増幅

Grant number：21679004  2009 - 2010

科学研究費助成事業  若手研究(S)

造血幹細胞-骨芽細胞ニッチ相互作用の成立・維持の分子機構

Grant number：18689024  2006 - 2008

科学研究費助成事業  若手研究(A)

造血幹細胞ニッチと細胞分裂制御

Grant number：16002011  2004 - 2008

日本学術振興会  科学研究費助成事業  特別推進研究

造血幹細胞の支持細胞「ニッチ細胞」としての骨芽細胞の機能解析

Grant number：16790542  2004 - 2005

科学研究費助成事業  若手研究(B)

M-CSF,RANKLによる破骨細胞の分化誘導と機能発現に関する研究

Grant number：00J04597  2000 - 2002

日本学術振興会  科学研究費助成事業  特別研究員奨励費

M-CSF,RANKLによる破骨細胞の分化誘導と機能発現に関する研究

2000 - 2002

日本学術振興会  特別研究員

分子生物学概論

2019.4 - 2019.9   First semester

生命の科学Ａ

2019.4 - 2019.6   Spring quarter

生命の科学Ａ

2018.4 - 2018.6   Spring quarter

2015.12   Role：Participation   Title：大学院FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2015.8   Role：Participation   Title：医学科・生命科学科FD

Organizer：Undergraduate school department

2014.8   Role：Participation   Title：医学科・生命科学科FD

Organizer：[Undergraduate school/graduate school/graduate faculty]