YAO HISAYUKI
Organization
Faculty of Medical Sciences Department of Stem Cell Biology and Medicine Assistant Professor
School of Medicine Department of Medicine（Joint Appointment）
Title
Assistant Professor
Contact information
Tel
0926424836
External link
Degree
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Ph.D
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M.D.
Research Interests・Research Keywords
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Research theme：Bone Marrow Microenvironment of Hematopoietic Malignancies
Keyword：Leukemia, Multiple Myeloma
Research period： 2019.9 - 2024.9
Papers
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POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis. Invited Reviewed International journal
Kentaro Nakashima, Yuya Kunisaki, Kentaro Hosokawa, Kazuhito Gotoh, Hisayuki Yao, Ryosuke Yuta, Yuichiro Semba, Jumpei Nogami, Yoshikane Kikushige, Patrick S Stumpf, Ben D MacArthur, Dongchon Kang, Koichi Akashi, Shouichi Ohga, Fumio Arai
Communications Biology 6 ( 1 ) 996 - 1009 2023.9 （ eISSN:2399-3642 ）
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POT1a IS ESSENTIAL FOR MESENCHYMAL NICHES SUPPORTING B CELL DEVELOPMENT
Nakashima, K; Kunisaki, Y; Hosokawa, K; Yao, H; Yuta, R; Akashi, K; Ohga, S; Arai, F
PEDIATRIC BLOOD & CANCER 69 2022.11 （ ISSN:1545-5009 eISSN:1545-5017 ）
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Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45 - TER119 - Erythroid and Lymphoid Progenitors. Reviewed International journal
Kazuhito Gotoh, Yuya Kunisaki, Soichi Mizuguchi, Daiki Setoyama, Kentaro Hosokawa, Hisayuki Yao, Yuya Nakashima, Mikako Yagi, Takeshi Uchiumi, Yuichiro Semba, Jumpei Nogami, Koichi Akashi, Fumio Arai, Dongchon Kang
iScience 23 ( 22 ) 101654 2021.11
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Pan-PI3Ki targets multiple B-ALL microenvironment interactions that fuel systemic and CNS relapse. Reviewed International journal
Sarah M Ridge, Andrew E Whiteley, Hisayuki Yao, Trevor T Price, Maegan L Brockman, Andrew S Murray, Brennan G Simon, Prioty Islam, Dorothy A Sipkins
Leukemia and Lymphoma 62 ( 11 ) 2690 - 2702 2021.8
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Leukaemia hijacks a neural mechanism to invade the central nervous system Reviewed
Hisayuki Yao, Trevor T. Price, Gaia Cantelli, Brandon Ngo, Matthew J. Warner, Lindsey Olivere, Sarah M. Ridge, Elizabeth M. Jablonski, Joseph Therrien, Stacey Tannheimer, Chad M. McCall, Anjen Chenn, Dorothy A. Sipkins
Nature 560 ( 7716 ) 55 - 60 2018.8
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496 ( 2 ) 490 - 496 2018.2
Presentations
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急性リンパ性白血病の中枢神経浸潤 Invited
八尾尚幸
第81回日本血液学会学術集会 2019.10
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Acute lymphoblastic leukemia cells invade the central nervous system by secret paths to avoid blood brain barrier
Hisayuki Yao, Trevor T. Price, Matthew J. Warner, Gaia Cantelli, Lindsey Olivere, Brandon Ngo, Sarah Ridge, Joe Therrien, Stacey Tannheimer, Chad McCall, Anjen Chenn & Dorothy A. Sipkins
2018.10
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急性リンパ性白血病の中枢神経浸潤経路 Invited
八尾尚幸
第41回日本炎症・再生医学会 2020.7
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急性リンパ性白血病の中枢神経浸潤経路の解明と中枢神経浸潤の新規予防療法の可能性 Invited
八尾尚幸
第61回日本小児血液・がん学会学術集会 2019.11
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Nakashima Kentaro, Kunisaki Yuya, Hosokawa Kentaro, Yao Hisayuki, Yuta Ryosuke, Akashi Koichi, Ohga Shouichi, Arai Fumio
日本小児血液・がん学会雑誌 2022.10 (一社)日本小児血液・がん学会
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Nguyen Ngan, Yao Hisayuki, Hosokawa Kentaro, Yuta Ryosuke, Esaki Yuki, Arai Fumio
日本血液学会学術集会 2023.10 (一社)日本血液学会
MISC
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急性リンパ性白血病の中枢神経浸潤経路
八尾尚幸
血液内科 2021.12
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間葉系幹細胞の基礎研究と臨床応用
八尾尚幸
生体の科学 2021.4
Professional Memberships
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The Japanese Society of Internal Medicine
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The Japanese Society of Hematology
Academic Activities
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Screening of academic papers
Role(s)： Peer review
2022
Research Projects
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UBE学術振興財団 第64回学術奨励賞
2024
Grant type：Donation
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Grant number：23K27626 2023.4 - 2026.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Grant type：Scientific research funding
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化学療法後の白血病再発における骨髄微小環境の解析
Grant number：22K08478 2022 - 2024
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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令和3年度 新日本先進医療研究財団 助成金
2021
Grant type：Donation
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Grant number：20H03711 2020.4 - 2023.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Arai Fumio
Grant type：Scientific research funding
This study investigated the function and aging regulation of mesenchymal stem cells (MSCs), the primary niche cells of hematopoietic stem cells (HSCs). We focused on the functional role of the shelterin factor POT1a in regulating MSC. MSC function, which declines with aging, is postulated to be involved in the functional decline of HSCs. This study found that POT1a maintains the stem cell activity of MSCs and their capacity to differentiate into osteoblasts and suppresses their functional decline with aging. In addition, the study showed that loss of POT1a reduced the hematopoietic supportive capacity of MSCs and impaired HSC function. These findings suggest that POT1a is essential in maintaining MSCs and their function as niche cells. The results of this study may be a crucial step toward establishing methods for the prevention and treatment of aging-related hematologic diseases.
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2020年度日本血液学会研究助成事業
2020
Grant type：Donation
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多発性骨髄腫の骨髄微小環境と新規治療法の開発
2019.6 - 2022.9
Authorship：Principal investigator
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多発性骨髄腫の微小環境の病態解明と治療法の開発
Grant number：19158012 2019 - 2021
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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2019年度持田記念研究助成金 加齢に伴う多発性骨髄腫発症メカニズムの解明
2019
Grant type：Donation
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2019年金原一郎記念医学医療振興財団基礎医学医療研究助成金
2019
Grant type：Donation
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2019年度武田科学振興財団医学系研究助成
2019
Grant type：Donation
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令和元年度新日本先進医療研究財団助成金 骨髄微小環境の加齢性変化と多発性骨髄腫発症の関連性についての基礎的研究
2019
Grant type：Donation
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Grant number：19K08841
八尾 尚幸
Grant type：Scientific research funding
多発性骨髄腫は近年相次ぐ分子標的治療薬の登場により、治療成績が大幅に向上したが、未だ再発難治性の疾患である。骨髄腫の進展は、骨髄腫とそれを取り巻く骨髄微小環境との相互作用が大きく関与しており、これまで骨芽細胞や破骨細胞の役割については知られているが、間葉系幹細胞については不明な点が多い。本研究では骨髄腫を支持する間葉系幹細胞をはじめとした骨髄微小環境を構成する細胞を同定し、それらの骨髄腫細胞の進展や再発に対する役割を解明する。さらに化学療法による骨髄微小環境の変化についても解析を行い、骨髄腫と間葉系幹細胞の相互作用を治療標的とした新たな骨髄腫治療法開発を目指す。