UMEYAMA TAICHI
Organization
Faculty of Medical Sciences Department of Stem Cell Biology and Medicine Assistant Professor
Title
Assistant Professor
External link
Papers
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Umeyama, T; Matsuda, T; Nakashima, K
CELLS 13 ( 8 ) 2024.4 （ eISSN:2073-4409 ）
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Takano J., Ito S., Dong Y., Sharif J., Nakajima-Takagi Y., Umeyama T., Han Y.W., Isono K., Kondo T., Iizuka Y., Miyai T., Koseki Y., Ikegaya M., Sakihara M., Nakayama M., Ohara O., Hasegawa Y., Hashimoto K., Arner E., Klose R.J., Iwama A., Koseki H., Ikawa T.
Nature Communications 13 ( 1 ) 2022.12
Research Projects
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腸内真菌による免疫系を介した社会性行動制御機構の解明と行動異常改善法の創出
Grant number：25K09596 2025.4 - 2028.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
梅山 大地
Grant type：Scientific research funding
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Grant number：21H02808 2021.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Matsuda Taito
Grant type：Scientific research funding
Neural stem cells in the subgranular zone of the hippocampal dentate gyrus of adult mammalian brains, including humans, have been observed to produce new neurons throughout life. However, recent reports have indicated that ectopic placement of some of these newborn neurons into the hilus may be epileptogenic. The detailed mechanism of this phenomenon remains unclear. In this study, we employed our own mouse model of increased seizure susceptibility to investigate the potential role of alterations in the intestinal microbiota in ectopic neurogenesis in the adult hippocampus. They demonstrated that elimination of specific intestinal bacteria through antimicrobial administration can effectively decrease the increased seizure susceptibility.
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Grant number：21K06141 2021.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Umeyama Taichi
Grant type：Scientific research funding
Fungi are not only rare in the microflora, but their genetic information is encoded on multiple chromosomes, making it impossible to reconstruct the entire genome from metagenomic data. For this reason, isolation culture is essential in conventional genome analysis, and the genomes of fungi that cannot be cultured cannot be analyzed. In this study, I aimed to establish a mini-metagenomic analysis method for genome analysis of fungi that cannot be cultured, by isolating and enriching fungi from the microflora, and I developed the following methods: (1) creation of probes for magnetic separation and FACS sorting and improvement of their affinity using protein engineering methods, (2) Optimization of conditions for fungal enrichment by density gradient centrifugation, and (3) Acquisition of bacteria-specific bacteriolysis enzymes and investigation of reaction conditions.
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Grant number：17H06305
伊藤 隆司, 梅山 大地, 荒木 啓充
Grant type：Scientific research funding
トランスオミクスにおいて重要なエピゲノム解析技術の高感度化および多重化に取り組み、独自のTACSライゲーションを開発してメチローム解析技術PBATを高度化するとともに、新規in vivoゲノムフットプリント法DMS-seqを開発した。更に、TACSライゲーションを利用して非定型的DNA構造に富む新規セルフリーDNAを発見した。また多重エピゲノム解析技術開発の基盤となる新規DNAメチル化酵素を同定した。