Updated on 2024/07/28

Information

 

写真a

 
MIZUNO SHINICHI
 
Organization
Faculty of Medical Sciences Department of Health Sciences Professor
Kyushu University Hospital Department of Advanced Molecular and Cell Therapy(Joint Appointment)
School of Medicine Department of Health Sciences(Joint Appointment)
Graduate School of Medical Sciences Department of Health Sciences(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426745
Profile
教育活動では、専門科目として検査技術科学専攻学生に「血液検査学」、「血液検査学実習」、「形態検査学特論」、「組織病理検査学および実習III」「医用工学・情報概論」を担当しており、大学院では、修士課程で共通教育科目「国際社会とチーム医療」および専門科目「病態情報解析学」を、博士後期課程では、「病態情報解析学Ⅰ」、「病態情報解析学Ⅱ」を担当している。 研究活動では、血液疾患診断への遺伝子解析の応用、腫瘍免疫の誘導法および検査技術の開発を行っている。

Degree

  • Ph.D in Medicine

Research Interests・Research Keywords

  • Research theme:Genetic analysis of hematological disorders

    Keyword:Genetic analysis, hematological disorders

    Research period: 2015.4 - 2022.3

  • Research theme:Comprehensive analysis of tumor immunity

    Keyword:tumor immunity

    Research period: 2012.8 - 2022.3

  • Research theme:Basic research on genome editing

    Keyword:genome editing

    Research period: 2010.4 - 2022.3

Papers

  • Prognostic impact of HLA supertype mismatch in single-unit cord blood transplantation. Reviewed International journal

    Sugio T, Uchida N, Miyawaki K, Ohno Y, Eto T, Mori Y, Yoshimoto G, Kikushige Y, Kunisaki Y, Mizuno S, Nagafuji K, Iwasaki H, Kamimura T, Ogawa R, Miyamoto T, Taniguchi S, Akashi K, Kato K.

    Bone Marrow Transplant   59 ( 4 )   466 - 472   2024.10

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-023-02183-1

  • Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers. Reviewed International journal

    Kobayashi Y, Niida A, Nagayama S, Saeki K, Haeno H, Takahashi KK, Hayashi S, Ozato Y, Saito H, Hasegawa T, Nakamura H, Tobo T, Kitagawa A, Sato K, Shimizu D, Hirata H, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Mizuno S, Kawazu M, Kohsaka S, Ueno T, Mano H, Ishihara S, Uemura M, Mori M, Doki Y, Eguchi H, Oshima M, Suzuki Y, Shibata T, Mimori K.

    Br J Cancer   129 ( 7 )   1105 - 1118   2023.10

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41416-023-02395-8

  • Three-dimensional topological radiogenomics of epidermal growth factor receptor Del19 and L858R mutation subtypes on computed tomography images of lung cancer patients. Reviewed International journal

    Ninomiya K, Arimura H, Tanaka K, Chan WY, Kabata Y, Mizuno S, Gowdh NFM, Yaakup NA, Liam CK, Chai CS, Ng KH.

    Computer Methods and Programs in Biomedicine   2023.6

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cmpb.2023.107544

  • CT Image-Based Biopsy to Aid Prediction of HOPX Expression Status and Prognosis for Non-Small Cell Lung Cancer Patients. Reviewed International journal

    Jin Y, Arimura H, Cui Y, Kodama T, Mizuno S, Ansai S.

    Cancers   15 ( 8 )   2220   2023.4

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers15082220

  • RHAMM marks proliferative subpopulation of human colorectal cancer stem cells. Reviewed International journal

    Nakano M, Taguchi R, Kikushige Y, Isobe T, Miyawaki K, Mizuno S, Tsuruta N, Hanamura F, Yamaguchi K, Yamauchi T, Ariyama H, Kusaba H, Nakamura M, Maeda T, Kuo CJ, Baba E, Akashi K.

    Cancer Science   2023.3

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.15795

  • Translocation of nuclear chromatin distribution to the periphery reflects dephosphorylated threonine-821/826 of the retinoblastoma protein (pRb) in T24 cells treated with Bacillus Calmette-Guérin. Reviewed International journal

    75 ( 1 )   49 - 62   2023.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10616-022-00559-7

  • Prospective study of adoptive activated αβT lymphocyte immunotherapy for refractory cancers: development and validation of a response scoring system. Reviewed International journal

    25 ( 1 )   76 - 81   2023.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jcyt.2022.09.007

  • Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories. Reviewed International journal

    Mizuno S, Yamaguchi R, Hasegawa T, Hayashi S, Fujita M, Zhang F, Koh Y, Lee SY, Yoon SS, Shimizu E, Komura M, Fujimoto A, Nagai M, Kato M, Liang H, Miyano S, Zhang Z, Nakagawa H, Imoto S.

    Scientific Reports   11 ( 1 )   15713   2022.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Immunomodulatory Cell Therapy Using αGalCer-Pulsed Dendritic Cells Ameliorates Heart Failure in a Murine Dilated Cardiomyopathy Model. Reviewed International journal

    15 ( 12 )   e009366   2022.6

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/CIRCHEARTFAILURE.122.009366

  • Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions. Reviewed International journal

    Ito M, Nakano M, Ariyama H, Yamaguchi K, Tanaka R, Semba Y, Sugio T, Miyawaki K, Kikushige Y, Mizuno S, Isobe T, Tanoue K, Taguchi R, Ueno S, Kawano T, Murata M, Baba E, Akashi K.

    Cancer Letters   28 ( 532 )   215597   2022.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Optimization of lymphapheresis for manufacturing autologous CAR-T cells. Reviewed International journal

    Yamanaka I, Yamauchi T, Henzan T, Sakoda T, Miyamoto K, Mishima H, Ono H, Koga Y, Nakashima Y, Kato K, Miyamoto T, Mizuno S, Ogawa Y, Ohga S, Akashi K, Maeda T, Kunisaki Y.

    International Journal of Hematology   114 ( 4 )   449 - 458   2021.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Impaired tumor immune response in metastatic tumors is a selective pressure for neutral evolution in CRC cases. Invited Reviewed International journal

    Sakimura S, Nagayama S, Fukunaga M, Hu Q, Kitagawa A, Kobayashi Y, Hasegawa T, Noda M, Kouyama Y, Shimizu D, Saito T, Niida A, Tsuruda Y, Otsu H, Matsumoto Y, Uchida H, Masuda T, Sugimachi K, Sasaki S, Yamada K, Takahashi K, Innan H, Suzuki Y, Nakamura H, Totoki Y, Mizuno S, Ohshima M, Shibata T, Mimori K.

    PLoS Genetics   17   e1009113   2021.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Successful correction of factor V deficiency of patient-derived iPSCs by CRISPR/Cas9-mediated gene editing. Invited Reviewed International journal

    Nakamura T, Morishige S, Ozawa H, Kuboyama K, Yamasaki Y, Oya S, Yamaguchi M, Aoyama K, Seki R, Mouri F, Osaki K, Okamura T, Mizuno S, Nagafuji K.

    Haemophilia   26   826 - 833   2021.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Neoantimon: a multifunctional R package for identification of tumor-specific neoantigens. Invited Reviewed International journal

    Hasegawa T, Hayashi S, Shimizu E, Mizuno S, Niida A, Yamaguchi R, Miyano S, Nakagawa H, Imoto S.

    Bioinformatics   36   4813 - 4816   2021.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Robust radiogenomics approach to the identification of EGFR mutations among patients with NSCLC from three different countries using topologically invariant Betti numbers. Reviewed International journal

    Ninomiya K, Arimura H, Chan WY, Tanaka K, Mizuno S, Muhammad Gowdh NF, Yaakup NA, Liam CK, Chai CS, Ng KH.

    PLoS One   16 ( 1 )   e0244354   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0244354

  • Pan-cancer analysis of whole genomes. Invited Reviewed International journal

    ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium

    Nature   578   82 - 93   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • CRISPR/Cas9-mediated Gene Correction in Hemophilia B Patient-Derived iPSCs Reviewed International journal

    Satoshi Morishige, Shinichi Mizuno, Hidetoshi Ozawa, Takayuki Nakamura, Ahmad Mazahery, Kei Nomura, Ritsuko Seki, Fumihiko Mouri, Koichi Osaki, Kenichi Yamamura, Takashi Okamura, Koji Nagafuji

    International Journal of Hematology   111 ( 2 )   225 - 233   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-019-02765-0

  • ALPHLARD-NT: Bayesian Method for Human Leukocyte Antigen Genotyping and Mutation Calling through Simultaneous Analysis of Normal and Tumor Whole-Genome Sequence Data. Reviewed International journal

    Hayashi S, Moriyama T, Yamaguchi R, Mizuno S, Komura M, Miyano S, Nakagawa H, Imoto S.

    J Comput Biol.   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer. Reviewed International journal

    Nakano M, Kikushige Y, Miyawaki K, Kunisaki Y, Mizuno S, Takenaka K, Tamura S, Okumura Y, Ito M, Ariyama H, Kusaba H, Nakamura M, Maeda T, Baba E, Akashi K.

    Oncogene   2019.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • ALPHLARD: a Bayesian method for analyzing HLA genes from whole genome sequence data. Reviewed International journal

    Hayashi S, Yamaguchi R, Mizuno S, Komura M, Miyano S, Nakagawa H, Imoto S.

    BMC Genomics   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Notch1 expression is regulated at the post-transcriptional level by the 3' untranslated region in hematopoietic stem cell development. Reviewed International journal

    Mizuno S, Iino T, Ozawa H, Arinobu Y, Chong Y, Akashi K

    Int J Hematol   107   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell. Reviewed International journal

    Shima T, Miyamoto T, Kikushige Y, Yuda J, Tochigi T, Yoshimoto G, Kato K, Takenaka K, Iwasaki H, Mizuno S, Goto N, Akashi K

    Exp Hematol   42   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • A case of 8p11 myeloproliferative syndrome with BCR-FGFR1 gene fusion presenting with trilineage acute leukemia/lymphoma, successfully treated by cord blood transplantation. Reviewed International journal

    Morishige S, Oku E, Takata Y, Kimura Y, Arakawa F, Seki R, Imamura R, Osaki K, Hashiguchi M, Yakushiji K, Mizuno S, Yoshimoto K, Nagafuji K, Ohshima K, Okamura T

    Acta Haematol   129   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • p600 Plays Essential Roles in Fetal Development. Reviewed International journal

    Nakaya T, Ishiguro KI, Belzil C, Rietsch AM, Yu Q, Mizuno SI, Bronson RT, Geng Y, Nguyen MD, Akashi K, Sicinski P, Nakatani Y

    PLoS One   8   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Unrelated cord blood transplantation for patients with adult T-cell leukemia/lymphoma: experience at a single institute. Int J Hematol. 96: 657-63, 2012 Reviewed International journal

    Int J Hematol. 96(5): 657-663, 2012

    Int J Hematol   96   2012.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Reviewed International journal

    Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P

    Cell   138   2009.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • FLT3-ITD upregulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Reviewed International journal

    Yoshimoto G, Miyamoto T, Jabbarzadeh-Tabrizi S, Iino T, Rocnik JL, Kikushige Y, Mori Y, Shima T, Iwasaki H, Takenaka K, Nagafuji K, Mizuno S, Niiro H, Gilliland GD, Akashi K

    Blood   114   2009.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Reviewed International journal

    Arinobu Y, Mizuno S, Chong Y, Shigematsu H, Iino T, Iwasaki H, Graf T, Mayfield R, Chan S, Kastner P, Akashi K

    Cell Stem Cell   1   2007.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Reviewed International journal

    Iwasaki H, Mizuno S, Arinobu Y, Ozawa H, Mori Y, Shigematsu H, Takatsu K, Tenen DG, Akashi K

    Genes Dev   20   2006.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • C/EBPbeta is required for 'emergency' granulopoiesis. Reviewed International journal

    Hirai H, Zhang P, Dayaram T, Hetherington CJ, Mizuno S, Imanishi J, Akashi K, Tenen DG

    Nature Immunology   7   2006.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Reviewed International journal

    Opferman JT, Iwasaki H, Ong CC, Suh H, Mizuno S, Akashi K, Korsmeyer SJ

    Science   307   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Reviewed International journal

    Iwasaki H, Somoza C, Shigematsu H, Duprez EA, Iwasaki-Arai J, Mizuno S, Arinobu Y, Geary K, Zhang P, Dayaram T, Fenyus ML, Elf S, Chan S, Kastner P, Huettner CS, Murray R, Tenen DG, Akashi K

    Blood   106   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Identification of eosinophil lineage-committed progenitors in the murine bone marrow. J Exp Med. 201: 1891-7, 2005 Reviewed International journal

    Iwasaki H, Mizuno S, Mayfield R, Shigematsu H, Arinobu Y, Seed B, Gurish MF, Takatsu K, Akashi K

    Proc Natl Acad Sci U S A   102   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Reviewed International journal

    Huntly BJ, Shigematsu H, Deguchi K, Lee BH, Mizuno S, Duclos N, Rowan R, Amaral S, Curley D, Williams IR, Akashi K, Gilliland DG

    Cancer Cell   6   2004.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Reviewed International journal

    Shigematsu H, Reizis B, Iwasaki H, Mizuno S, Hu D, Traver D, Leder P, Sakaguchi N, Akashi K

    Immunity   21   2004.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages. Reviewed International journal

    Iwasaki H, Mizuno S, Wells RA, Cantor AB, Watanabe S, Akashi K

    Immunity   19   2003.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Expression of DNA methyltransferases DNMT1, 3A and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Reviewed International journal

    Mizuno S, Chijiwa T, Okamura T, Akashi K, Fukumaki Y, Niho Y, Sasaki H

    Blood   91   2001.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Epstein-Barr virus-infected natural killer cell leukemia. Reviewed International journal

    Akashi K, Mizuno S

    Leuk Lymphoma   40   2000.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hypercoagulable state following transfusions of granulocytes obtained from granulocyte colony- stimulating factor-stimulating donors. Reviewed International journal

    Mizuno S, Okamura T, Iwasaki H, Ohno Y, Akashi K, Inaba S, Niho Y

    Int J Hematol   72   2000.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinting region of mouse chromosome 7. Reviewed International journal

    Kato R, Shirohzu H, Yokomine T, Mizuno S, Mukai T, Sasaki H

    DNA Research   6   1999.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Interferon-gamma prevents apoptosis in Epstein-Barr virus-infected natural killer cell leukemia in an autocrine fashion. Reviewed International journal

    Mizuno S, Akashi K, Ohshima K, Iwasaki H, Miyamoto T, Uchida N, Shibuya T, Harada M, Kikuchi M, Niho Y

    Blood   93   1999.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Position-independent human beta-globin gene expression mediated by a recombinant adeno-associated virus vector carrying the chicken beta-globin insulator. Reviewed International journal

    Inoue T, Yamaza H, Sakai Y, Mizuno S, Ohno M, Hamasaki N, Fukumaki Y

    J Hum Genet   44   1999.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Increased incidence of cytomegalovirus(CMV) infection and CMV-associated disease after allogeneic bone marrow transplantation from unrelated donors. Reviewed International journal

    Takenaka K, Gondo H, Tanimoto K, Nagafuji K, FujisakiT, Mizuno S, Miyamoto T, Okamura T, Hayashi S, Eto T, Osaki K, Yamasaki K, Shibuya T, Harada N, Teshima T, Matuishi E, Minematus T, Minamishima Y, Harada M, Niho Y

    Bone Marrw Transplant   19   1997.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Autologous peripheral blood stem cell transplantation for acute myelogenous leukemia. Reviewed International journal

    Gondo H, Harada M, Miyamoto T, Takenaka K, Tanimoto K, Mizuno S, Fujisaki T, Nagafuji K, Hayashi S, Eto T, Taniguchi S, Akashi K, Harada N, Yamasaki K, Shibuya T, Matsuishi E, Ohno Y, Makino S, Takamatsu Y, Murakawa M, Teshima T, Hirota Y, Okamura T, Kinukawa N, Niho Y

    Bone Marrow Transplant   20   1997.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Granulocyte colony-stimulating factor-combined marrow-ablative chemotherapy and autologous blood cell transplantation for the treatment of patients with acute yelogenous leukemia in first remission. Reviewed International journal

    Harada M, Akashi K, Hayashi S, Eto T, Takamatsu Y, Teshima T, Hirota Y, Taniguchi S, Nagafuji K, Mizuno S, Gondo H, Niho Y

    Int J Hematol   66   1997.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Collection and transplantation of autologous peripheral blood stem cells in adults. Reviewed International journal

    Miyamoto T, Inaba S, Harada M, Makino S, Teshima T, Takamatsu Y, Eto T, Nagafuji K,Mizuno S, Gondo H, Niho Y

    Jap J Apheresis   16   1997.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • In vitro expansion of hematopoietic progenitor cells induces functional expression of Fas antigen(CD95). Reviewed International journal

    Takenaka T, Nagafuji K, Harada M, Mizuno S, Miyamoto T, Makino S, Gondo H, Okamura T, Niho Y

    Blood   88   1996.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • In vitro expansion of hematopoietic progenitor cells induces functional expression of Fas antigen(CD95). Reviewed International journal

    Takenaka T, Nagafuji K, Harada M, Mizuno S, Miyamoto T, Makino S, Gondo H, Okamura T, Niho Y

    Blood   88   1996.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • G-CSF-induced mobilization of peripheral blood stem cells from healthy adults for allogeneic transplantation. Reviewed International journal

    Harada M, Nagafuji K, Fujisaki T, Kubota A, Mizuno S, Takenaka K, Miyamoto T, Ohno Y, Gondo H, Kuroiwa M, Okamura T, Inaba S, Niho Y

    J Hematother   5   1996.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Persistence of multipotent progenitors expressing AML1 / ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia. Reviewed International journal

    Miyamoto T, Nagafuji K, Akashi K, Harada M, Kyo T, Akashi T, Takenaka K, Mizuno S, Gondo H, Okamura T, Dohy H, Niho Y

    Blood   87   1996.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Generation of human natural killer cells from peripheral blood CD34+cells mobilized by granulocyte colony-stimulating factor. Reviewed International journal

    Takenaka K, Mizuno S, Harada M, Nagafuji K, Miyamoto T, Iwasaki H, Fujisaki T, Kubota A, Ohno Y, Arima F, Shigematsu H, Gondo H, Okamura T, Okamura S, Inaba S, Niho Y

    Br J Haematol   92   1996.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Functional expression of Fas antigen(CD95) on hematopoietic progenitor cells. Reviewed International journal

    Nagafuji K, Shibuya T, Harada M, Mizuno S, Takenaka K, Miyamoto T, Okamura T, Gondo H, Niho Y

    Blood   86   1995.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hepatosinusoidal leukemia / lymphoma consisting of Epstein-Barr virus-containing natural killer cell leukemia / lymphoma and T-cell lymphoma; mimicking malignant histiocytosis. Reviewed International journal

    Ohshima K, Kikuchi M, Mizuno S, Akashi K, Moriyama K, Yoneda S, Takeshita M, Shibata T

    Hematological Oncol   13   1995.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Quantitative analysis of AML1 / ETO transcripts in peripheral blood stem cell harvests from patients with t(8;21) acute myelogenous leukemia. Reviewed International journal

    Miyamoto T, Nagafuji K, Harada M, Eto T, Fujisaki T, Kubota A, Akashi K, Mizuno S, Takenaka K, Kanaji T, Gondo H, Okamura T, Inaba S, Niho Y

    Br J Haematol   91   1995.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Characterization of blasts from a patient with eosinophilic blast crisis of chronic myelogenous leukaemia. Reviewed International journal

    Miyamoto T, Nagafuji K, Harad M, Yamasaki K, Shibuya T, Iwasaki H, Akashi K, Mizuno S, Eto T, Takenaka K, Gondo H, Okamura T, Niho Y

    Br J Haematol   89   1995.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • T lymphoid / myeloid bilineal crisis in chronic myelogenous leukemia. Reviewed International journal

    Akashi K, Mizuno S, Harada M, Kimura N, Kinjyo M, Shibuya T, Shimoda K, Takeshita M, Okamura S, Matsumoto I, Kikuchi M, Niho Y

    Exp Hematol   21   1993.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Filgrastim treatment of leukaemic transformation in myelodysplastic syndrome. Reviewed International journal

    Mizuno S, Akashi K, Hirota Y, Gyoten S, Matsumoto I, Harada M, Niho Y

    Lancet   341   1993.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Presentations

  • CRISPR/Cas9による一塩基改変iPSCを用いたアントラサイクリン関連心毒性とSNPの関連解析

    中村 剛之、水野 晋一、小澤 秀俊、森重 聡、山崎 嘉孝、大屋 周期、 山口 真紀、関 律子、毛利 文彦、大崎 浩一、長藤 宏司

    第81回日本血液学会学術集会  2019.10 

     More details

    Event date: 2019.10

    Language:Japanese  

    Country:Japan  

  • 先天性第V因子欠損症由来iPS細胞におけるCRISPR/Cas9システムの治療応用

    中村 剛之、水野 晋一、小澤 秀俊、森重 聡、岡村 孝、長藤 宏司

    第17回日本再生医療学会総会  2018.3 

     More details

    Event date: 2018.3

    Language:Japanese  

    Venue:パシフィコ横浜   Country:Japan  

MISC

  • 造血・免疫・止血のしくみ: 4.免疫担当細胞とその分化機構 3)B細胞 (専門医のための血液病学) Reviewed

    水野 晋一

    2022.4

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 急性骨髄性白血病のゲノム医療

    水野晋一

    血液内科   2021.8

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 造血幹細胞の分化と制御

    水野晋一

    2018.12

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 腫瘍免疫における遺伝子変異集積の意義−がん免疫療法臨床試験からのレッスン

    水野晋一

    遺伝子医学MOOK がん免疫療法   2017.11

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • HLAタイピング・TCRレパトア解析による免疫ゲノムプロファイリング

    井元清哉、山口類、水野晋一、中川英刀

    実験医学   2017.4

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 遺伝子診断の最先端-ゲノミクスの進歩と個別化医療

    水野晋一

    検査血液学会雑誌   2017.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 遺伝子検査の進歩-がんの遺伝子検査

    水野晋一

    臨床と研究   2016.8

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 造血器腫瘍における免疫療法の最先端

    水野晋一

    がん分子標的治療   2015.4

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 癌幹細胞における特異的腫瘍抗原をターゲットとした免疫療法

    水野晋一

    医学のあゆみ   2014.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • ゲノムインプリンティング—ヒトとマウスの分子遺伝学的研究からみたそのメカニズム.

    水野晋一、佐々木裕之

    遺伝子医学   1998.2

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 末梢血幹細胞採取時におけるCD34陽性細胞中のCDw90(Thy-1)陽性率測定の意義.

    宮本 京子、大塚 輝久、水野 晋一、船津 清香、稲葉 頌一

    臨床血液   1997.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • アポトーシスと疾患‐Fas抗原/ Fas ligandとアポトーシス.

    竹中克斗、水野晋一、仁保喜之

    現代医療   1997.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • MDSに対するlow-dose aclarubicinおよびvery low-dose Ara-C療法.

    渋谷恒文、長藤宏司、水野晋一、原田実根

    臨床血液   1996.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 末梢血幹細胞移植.

    水野晋一、原田実根

    総合臨床   1996.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Fas/ Fas ligandシステムとアポトーシス.

    水野晋一、長藤宏司

    臨床医   1996.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Fas遺伝子の変異とリンパ球の異常増殖.

    水野晋一、長藤宏司

    臨床医   1996.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 成人急性白血病に対する末梢血幹細胞移植.

    水野晋一、豊嶋崇徳

    臨床血液   1996.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 臨床医学と血液型.

    水野晋一、仁保喜之

    日常診療と血液   1995.5

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 自家末梢血幹細胞移植術の進歩.

    稲葉頌一、大野裕樹、水野晋一

    日本臨床   1995.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 成人急性骨髄性白血病第一寛解期症例に対する末梢血幹細胞移植.

    水野晋一、原田実根

    日本輸血学会雑誌   1995.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • NK細胞性白血病とアポトーシス.

    水野晋一

    医学のあゆみ   1995.1

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 骨髄異形成症候群の治療 B)RAEBの治療.

    仁保喜之、水野晋一、赤司浩一、広田雄一

    日常診療と血液   1994.4

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Industrial property rights

Patent   Number of applications: 1   Number of registrations: 3
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 日本分子生物学会

  • 日本がん免疫学会

  • 日本免疫学会

  • 日本血液疾患免疫療法学会

  • 日本感染症学会

  • 日本再生医療学会

  • 日本輸血・細胞治療学会

  • 日本血液学会

  • 日本内科学会

▼display all

Committee Memberships

  • Councilor   Domestic

    2018.9 - 2024.9   

  • Councilor   Domestic

    2010.4 - 2024.3   

Research Projects

  • マイクロアレイと次世代シーケンサーを用いた新規遺伝子発現解析のための解析技術開発

    2023

      More details

    Grant type:Donation

  • マイクロアレイと次世代シークエンサーを用いた新規遺伝子発現解析のための解析技術開発

    2022.6 - 2025.5

    共同研究

      More details

    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • クローン造血(CH)環境の腫瘍発生・進展への機序およびCH環境の免疫学的制御

    Grant number:21K07153  2021 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 中外製薬研究活動支援/ 血友病をはじめとする先天性凝固性疾患のCRISPR/Cas9ゲノム編集による遺伝子修復

    2020

      More details

    Grant type:Donation

  • 中外製薬研究活動支援/ 血友病をはじめとする先天性凝固性疾患におけるCRISPR/Cas9による遺伝子修復

    2019

      More details

    Grant type:Donation

  • 中外製薬研究活動支援/ 血友病におけるCRISPR/Cas9 システムによる遺伝子修復

    2018

      More details

    Grant type:Donation

  • 造血幹細胞移植への応用に向けた次世代シーケンサーによる新規マイナー組織抗原の解析

    Grant number:16K09883  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 造血幹細胞移植への応用に向けた次世代シーケンサーによる新規マイナー組織抗原の解析

    Grant number:15H02775  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 階層ベイズによる高多様性領域HLAゲノムシークンス解析法の開発

    Grant number:25461464  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • ドナー由来白血病を含む造血幹細胞移植後の白血病再発に潜在する分子生物学的発症 基盤

    Grant number:25461464  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • ドナー由来白血病を含む造血幹細胞移植後の白血病再発に潜在する分子生物学的発症基盤

    Grant number:25461464  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 腫瘍ゲノム解析として転座・逆位を含む包括的構造解析を可能とする新規システムの開発

    Grant number:25640078  2013 - 2014

    科学研究費助成事業  挑戦的萌芽研究

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 新規システムによる骨髄増殖性疾患における未知の染色体転座および遺伝子変異の探索

    Grant number:23390255  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • Notch遺伝子の転写後調節による造血幹細胞の自己複製およびT細胞分化機構の解明

    Grant number:22390196  2010 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 悪性腫瘍における未知の融合遺伝子の発見を可能とする新規ベクターシステムの開発

    Grant number:22650234  2010 - 2011

    科学研究費助成事業  挑戦的萌芽研究

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • インスレーターを応用した造血幹細胞への遺伝子治療:長期安定発現系の確立

    1999 - 2000

    日本学術振興会  特別研究員

      More details

    Authorship:Principal investigator  Grant type:Joint research

▼display all

Class subject

  • 血液検査学実習

    2024.10 - 2025.3   Second semester

  • 検査技術科学特別研究

    2024.4 - 2025.3   Full year

  • 国際プレゼンテーション

    2024.4 - 2025.3   Full year

  • 保健学特別研究

    2024.4 - 2025.3   Full year

  • 病態情報解析検査学演習

    2024.4 - 2024.9   First semester

  • 人体の構造と機能Ⅰ

    2024.4 - 2024.9   First semester

  • 血液検査学

    2024.4 - 2024.9   First semester

  • 医用工学・情報概論

    2024.4 - 2024.9   First semester

  • International Society and Multidisciplinary Care

    2024.4 - 2024.9   First semester

  • 国際社会とチーム医療

    2024.4 - 2024.9   First semester

  • 病態情報解析学Ⅰ

    2024.4 - 2024.9   First semester

  • 臨床検査学概論Ⅰ

    2024.4 - 2024.6   Spring quarter

  • 血液検査学実習

    2023.10 - 2024.3   Second semester

  • 血液検査学

    2023.10 - 2024.3   Second semester

  • 検査技術科学特別研究

    2023.4 - 2024.3   Full year

  • 国際プレゼンテーション

    2023.4 - 2024.3   Full year

  • 保健学特別研究

    2023.4 - 2024.3   Full year

  • 病態情報解析検査学演習

    2023.4 - 2023.9   First semester

  • 人体の構造と機能Ⅰ

    2023.4 - 2023.9   First semester

  • 医用工学・情報概論

    2023.4 - 2023.9   First semester

  • International Society and Multidisciplinary Care

    2023.4 - 2023.9   First semester

  • 国際社会とチーム医療

    2023.4 - 2023.9   First semester

  • 病態情報解析学Ⅰ

    2023.4 - 2023.9   First semester

  • 臨床検査学概論Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 血液検査学実習

    2022.10 - 2023.3   Second semester

  • 血液検査学

    2022.10 - 2023.3   Second semester

  • 検査技術科学特別研究

    2022.4 - 2023.3   Full year

  • 国際プレゼンテーション

    2022.4 - 2023.3   Full year

  • 保健学特別研究

    2022.4 - 2023.3   Full year

  • 病態情報解析検査学演習

    2022.4 - 2022.9   First semester

  • 医用工学・情報概論

    2022.4 - 2022.9   First semester

  • 人体の構造と機能Ⅰ

    2022.4 - 2022.9   First semester

  • International Society and Multidisciplinary Care

    2022.4 - 2022.9   First semester

  • 国際社会とチーム医療

    2022.4 - 2022.9   First semester

  • 病態情報解析学Ⅰ

    2022.4 - 2022.9   First semester

  • 臨床検査学概論Ⅰ

    2022.4 - 2022.6   Spring quarter

  • 血液検査学実習

    2021.10 - 2022.3   Second semester

  • 血液検査学

    2021.10 - 2022.3   Second semester

  • 検査技術科学特別研究

    2021.4 - 2022.3   Full year

  • 国際プレゼンテーション

    2021.4 - 2022.3   Full year

  • 保健学特別研究

    2021.4 - 2022.3   Full year

  • International Society and Multidisciplinary Care

    2021.4 - 2021.9   First semester

  • 人体の構造と機能Ⅰ

    2021.4 - 2021.9   First semester

  • 医用工学・情報概論

    2021.4 - 2021.9   First semester

  • 国際社会とチーム医療

    2021.4 - 2021.9   First semester

  • 病態情報解析検査学演習

    2021.4 - 2021.9   First semester

  • 病態情報解析学Ⅰ

    2021.4 - 2021.9   First semester

  • 臨床検査学概論Ⅰ

    2021.4 - 2021.6   Spring quarter

  • 血液検査学

    2020.10 - 2021.3   Second semester

  • 人体の構造と機能Ⅰ

    2020.4 - 2020.9   First semester

  • 病態情報解析学Ⅰ

    2020.4 - 2020.9   First semester

  • 病態情報解析検査学演習

    2020.4 - 2020.9   First semester

  • 国際社会とチーム医療

    2020.4 - 2020.9   First semester

  • 血液検査学

    2019.10 - 2020.3   Second semester

  • 病態情報解析学Ⅰ

    2019.4 - 2019.9   First semester

  • 人体の構造と機能Ⅰ

    2019.4 - 2019.9   First semester

  • 血液検査学実習

    2019.4 - 2019.9   First semester

  • 国際社会とチーム医療

    2019.4 - 2019.9   First semester

  • 病態情報解析検査学演習

    2019.4 - 2019.9   First semester

  • 病態情報解析学Ⅱ

    2018.10 - 2019.3   Second semester

  • 血液検査学

    2018.10 - 2019.3   Second semester

  • 組織・病理検査学および実習Ⅲ

    2018.10 - 2019.3   Second semester

  • 形態検査学特論

    2018.10 - 2019.3   Second semester

  • 病態情報解析検査学

    2018.10 - 2019.3   Second semester

  • 血液検査学実習

    2018.4 - 2018.9   First semester

  • 国際社会とチーム医療

    2018.4 - 2018.9   First semester

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  久留米大学医学部血液・腫瘍内科 客員教授  Classification:Affiliate faculty 

  • 2023  久留米大学医学部血液・腫瘍内科 客員教授  Classification:Affiliate faculty 

  • 2022  久留米大学医学部血液・腫瘍内科 客員教授  Classification:Affiliate faculty 

  • 2021  久留米大学医学部血液・腫瘍内科 客員教授  Classification:Affiliate faculty 

  • 2020  久留米大学医学部血液・腫瘍内科 客員教授  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2019  久留米大学医学部血液・腫瘍内科 客員教授  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2019  鹿児島大学大学院医歯学総合研究科システム血栓制御学講座 客員教授  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2018  鹿児島大学大学院医歯学総合研究科システム血栓制御学講座 客員教授  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2018  久留米大学医学部血液・腫瘍内科 客員教授  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2017  鹿児島大学大学院医歯学総合研究科システム血栓制御学講座 客員教授  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2017  久留米大学医学部血液・腫瘍内科 客員准教授  Classification:Affiliate faculty  Domestic/International Classification:Japan 

▼display all

Other educational activity and Special note

  • 2024  Class Teacher 

  • 2023  Class Teacher 

  • 2022  Class Teacher 

  • 2021  Class Teacher 

  • 2020  Class Teacher 

  • 2019  Class Teacher 

▼display all

Educational Activities for Highly-Specialized Professionals in Other Countries

  • 2021.8   バングラデシュ臨床検査センター臨床検査技師向け遠隔講義

    Main countries of student/trainee affiliation:Bangladesh

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Hematology

Clinician qualification

  • Certifying physician

    日本輸血学会

  • Preceptor

    The Japanese Society of Hematology

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

  • Certifying physician

    日本再生医療学会

  • Certifying physician

    日本輸血・細胞治療学会

Year of medical license acquisition

  • 1989

Notable Clinical Activities

  • 細胞免疫治療委員会、委員