MIYATA KIYOKO
Organization
Faculty of Medical Sciences Department of Clinical Medicine Assistant Professor
School of Medicine Department of Medicine（Concurrent）
Title
Assistant Professor
Homepage
External link
ORCID
Research Areas
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Life Science / Cell biology
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Life Science / Molecular biology
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Life Science / Hematology and medical oncology
Degree
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PhD
Research History
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Kyushu University 医学研究院 Assistant Professor
2023.8 - Present
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Kyushu University 医学研究院 Specially Appointed Assistant Professor
2019.2 - 2023.7
Education
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Kyushu University 理学部 生物科学専攻
2004.4 - 2007.3
Country：Japan
Research Interests・Research Keywords
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Research theme： Development of Synergistic Drug Combinations to Overcome Venetoclax Resistance in Acute Myeloid Leukemia
Keyword： apoptosis
Research period： 2023.4 - 2024.5
Papers
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The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells. Reviewed
Terasaki T, Semba Y, Sasaki K, Imanaga H, Setoguchi K, Yamauchi T, Hirabayashi S, Nakao F, Akahane K, Inukai T, Sanda T, Akashi K, Maeda T
Leukemia 38 ( 9 ) 1918 - 1928 2024.9 （ ISSN:0887-6924 ）
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Central role of the mTORC1 pathway in glucocorticoid activity against B-ALL cells. Reviewed
Imanaga H, Semba Y, Sasaki K, Setoguchi K, Maniriho H, Yamauchi T, Terasaki T, Hirabayashi S, Nakao F, Nogami J, Izraeli S, Akashi K, Maeda T
Blood neoplasia 1 ( 2 ) 100015 2024.6
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Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance Reviewed International journal
Nakao F, Setoguchi K, Semba Y, Yamauchi T, Nogami J, Sasaki K, Imanaga H, Terasaki T, Miyazaki M, Hirabayashi S, Miyawaki K, Kikushige Y, Masuda T, Akashi K, Maeda T
Leukemia 37 1028 - 1038 2023.5
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Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes Reviewed International journal
Setoguchi K, Cui L, Hachisuka N, Obchoei S, Shinkai K, Hyodo F, Kato K, Wada F, Yamamoto T, Harada-Shiba M, Obika S, Nakano K
Molecular therapy. Nucleic acids 9 170 - 181 2017.12 （ ISSN:2162-2531 ）
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Small Nucleolar Noncoding RNA SNORA23, Up-Regulated in Human Pancreatic Ductal Adenocarcinoma, Regulates Expression of Spectrin Repeat-Containing Nuclear Envelope 2 to Promote Growth and Metastasis of Xenograft Tumors in Mice.
Cui L, Nakano K, Obchoei S, Setoguchi K, Matsumoto M, Yamamoto T, Obika S, Shimada K, Hiraoka N
Gastroenterology 153 ( 1 ) 292 - 306.e2 2017.7 （ ISSN:0016-5085 ）
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P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells.
Setoguchi K, TeSlaa T, Koehler CM, Teitell MA
Journal of molecular biology 428 ( 7 ) 1465 - 75 2016.4 （ ISSN:0022-2836 ）
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A small molecule inhibitor of redox-regulated protein translocation into mitochondria.
Dabir DV, Hasson SA, Setoguchi K, Johnson ME, Wongkongkathep P, Douglas CJ, Zimmerman J, Damoiseaux R, Teitell MA, Koehler CM
Developmental cell 25 ( 1 ) 81 - 92 2013.4 （ ISSN:1534-5807 ）
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Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells.
Zhang J, Nuebel E, Wisidagama DR, Setoguchi K, Hong JS, Van Horn CM, Imam SS, Vergnes L, Malone CS, Koehler CM, Teitell MA
Nature protocols 7 ( 6 ) 1068 - 85 2012.5 （ ISSN:1754-2189 ）
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UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.
Zhang J, Khvorostov I, Hong JS, Oktay Y, Vergnes L, Nuebel E, Wahjudi PN, Setoguchi K, Wang G, Do A, Jung HJ, McCaffery JM, Kurland IJ, Reue K, Lee WN, Koehler CM, Teitell MA
The EMBO journal 30 ( 24 ) 4860 - 73 2011.11 （ ISSN:0261-4189 ）
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Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells.
Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K
The Journal of cell biology 191 ( 6 ) 1141 - 58 2010.12 （ ISSN:0021-9525 ）
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A novel insertion pathway of mitochondrial outer membrane proteins with multiple transmembrane segments.
Otera H, Taira Y, Horie C, Suzuki Y, Suzuki H, Setoguchi K, Kato H, Oka T, Mihara K
The Journal of cell biology 179 ( 7 ) 1355 - 63 2007.12 （ ISSN:0021-9525 ）
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Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins.
Setoguchi K, Otera H, Mihara K
The EMBO journal 25 ( 24 ) 5635 - 47 2006.12 （ ISSN:0261-4189 ）
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Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import.
Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y
Molecular and cellular biology 22 ( 6 ) 1639 - 55 2002.3 （ ISSN:0270-7306 ）
MISC
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Mitochondria in human pluripotent stem cell apoptosis Reviewed
TeSlaa T, Setoguchi K, Teitell MA
2016.4
Research Projects
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Bcl2阻害剤抵抗性AMLにおける新規薬剤併用療法の開発
2023.4 - 2026.3
Authorship：Principal investigator
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Grant number：23K07816 2023 - 2025
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
宮田 喜代子
Authorship：Principal investigator Grant type：Scientific research funding
白血病の治療成績は、化学療法、分子標的療法、造血幹細胞移植法の進歩にも関わらず、 長期生存率は30%に満たず、新規治療法の開発が急務である。白血病難治性を規定する要因として、患者体内での白血病クローンの多様性が挙げられる。このように多様性に富んだ多種の白血病クローンの根絶には、多剤併用療法が有効であるが、臨床上での薬剤併用療法は、ほぼ経験的に構築されているのが現状であり、革新的な分子標的薬の開発が望まれている。本研究では、細胞・個体レベルの遺伝子異常を背景とする難治性白血病を克服することを目的として、白血病治療のキード ラッグと併用する分子標的薬の開発と、その分子機序について解析する。
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臨床研究助成金
2023
Grant type：Donation
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研究助成金
2023
Grant type：Donation
Educational Activities
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主に、これまでの研究活動を通して習得した生化学的・細胞生物学的知識を、教育活動として指導している。