Updated on 2024/07/28

Information

 

写真a

 
AYUKAWA YASUNORI
 
Organization
Faculty of Dental Science Department of Dental Science Professor
Abolition organization Oral Rehabilitation(Joint Appointment)
School of Dentistry Department of Dentistry(Joint Appointment)
Graduate School of Dental Science (Joint Appointment)
Graduate School of Dental Science Department of Dental Science(Joint Appointment)
Graduate School of Engineering Department of Mechanical Engineering(Joint Appointment)
Title
Professor
Tel
0926426441
Profile
Oral implant is an artificial tooth placed in the jaw bone. Implant material requires both excellent mechanical property and histocompatibility. Hydroxyapatite and titanium are supposed to fulfill the requirements. On the contrary, it is not known how these materials obtain the histocompatible property. We have been studying the histocompatibility of these materials, especially protein distribution around the implant. We showed that there was a thin amorphous layer between the bone and the materials and now we analyze the function of this layer. In addition, possibility of accelerating bone formation around the material is also studied. In addition, we have studied the treatment method for medication-related osteonecrosis of the jaw.

Degree

  • PhD

Research Interests・Research Keywords

  • Research theme:A study of the bacterial adhesin to the oral implant materials

    Keyword:implant, biocompatibility, microorganism, dental plaque

    Research period: 2008.3

  • Research theme:A study of bone augmentation in relation to implant therapy

    Keyword:implant, bone augmentation, top down treatment

    Research period: 2005.4

  • Research theme:A study of the improvement of biocompatibility of oral implant

    Keyword:implant, biocompatibility, titanium

    Research period: 1995.4

Awards

  • 日本補綴歯科学会中堅優秀論文賞

    2011.5   日本補綴歯科学会   Simvastatin enhances bone formation around titanium implants in rat tibiae.

  • 日本補綴歯科学会奨励論文賞

    2005.5   日本補綴歯科学会   Simvastatin promotes osteogenesis around titanium implants. A histological and histometrical study in rats

  • Best Oral Award

    2004.9   European Association for Osseointegration  

  • 日本補綴歯科学会課題口演コンペティション

    2003.10   日本補綴歯科学会   骨粗鬆症ラットにおけるチタン周囲骨形成に対する高脂血症治療薬シンバスタチンの効果

Papers

  • Association Between Reduced Posterior Occlusal Contact and Alzheimer’s Disease Onset in Older Japanese Adults: Results from the LIFE Study Reviewed International journal

    Journal of Alzheimer’s Disease   97   871 - 881   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3233/JAD-230449

  • Relationship between the magnitude of immediate loading and peri-implant bone strength in dogs. Reviewed International journal

    Daisuke Esaki, Yasuyuki Matsushita, Yasunori AYUKAWA, NOBUO SAKAI, Yoshinori Sawae, kiyoshi koyano

    Clinical Oral Implants Research   23 ( 11 )   1290 - 1296   2012.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-0501.2011.02305.x

  • The Effect of Low-Magnitude, High-Frequency Vibration Stimuli on the Bone Healing of Rat Incisor Extraction Socket. Reviewed International journal

    Takashi Kono, Yasunori AYUKAWA, Moriyama Yasuko, Kosaku Kurata, Hiroshi Takamatsu, kiyoshi koyano

    Journal of Biomechanical Engineering   134 ( 9 )   091001-1 - 091001-6   2012.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Bacterial adhesion affinities of various implant abutment materials Reviewed International journal

    Koichi Yamane, Yasunori AYUKAWA, Toru Takeshita, Akihiro Furuhashi, Yoshihisa Yamashita, kiyoshi koyano

    Clinical Oral Implants Research   in press   2012.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-0501.2012.02574.x

  • Relationship between the bone density estimated by cone-beam computed tomography and the primary stability of dental implants Reviewed International journal

    Isoda K, Ayukawa Y, Tsukiyama Y, Sogo M, Matsushita Y, Koyano K.

    Clinical Oral Implants Research   23 ( 7 )   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-0501.2011.02203.x

  • Effect of titanium surface calcium and magnesium on adhesive activity of epithelial-like cells and fibroblasts Reviewed International journal

    Okawachi H, Ayukawa Y, Atsuta I, Furuhashi A, Sakaguchi M, Yamane K, Koyano K.

    Biointerphases   7   2012.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13758-012-0027-9

  • The difference of fibroblast behavior on titanium substrata with different surface characteristics Reviewed International journal

    Akihiro Furuhashi, Yasunori AYUKAWA, ATSUTA IKIRU, Hideyuki Okawachi, kiyoshi koyano

    Odontology   100 ( 2 )   199 - 205   2012.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Evaluations of epithelial sealing and peri-implant epithelial down-growth around “step-type” implants Reviewed International journal

    23 ( 4 )   2012.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-0501.2011.02163.x

  • インプラントアバットメント材料としてのジルコニアに対する上皮性付着および生物学的幅径の形成 Reviewed

    古橋明大、鮎川保則、熱田 生、坂口真実、山根晃一、Rakhmatia YD、大川内秀幸、古谷野 潔

    別冊Quintessence Year Book 2012   2012.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Tissue-response to calcium-bonded titanium surface. Reviewed International journal

    Journal of Biomedical Materials Research   95A ( 1 )   2010.5

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  • Local application of fluvastatin improves peri-implant bone quantity and mechanical property. A rodent study. Reviewed International journal

    Moriyama Y, Ayukawa Y, Ogino Y, Atsuta I, Todo M, Takao Y, Koyano K.

    Acta Biomaterialia   6 ( 4 )   2010.4

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  • The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia. Reviewed International journal

    Masuzaki T, Ayukawa Y, Moriyama Y, Jinno Y, Atsuta I, Ogino Y, Koyano K.

    Biomaterials   31 ( 12 )   2010.4

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  • Simvastatin enhances bone formation around titanium implants in rat tibiae. Reviewed International journal

    Ayukawa Y, Ogino Y, Moriyama Y, Atsuta I, Jinno Y, Kihara M, Tsukiyama Y, Koyano K.

    Journal of Oral Rehabilitation   37 ( 2 )   2009.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • The alteration of peri-implant bone response exposed to static lateral load Reviewed International journal

    Moriyama Y, Ayukawa Y, Kabemura K, Matsushita Y, Kihara M, Tsukiyama Y, Todo M, Takao Y, Koyano K.

    Journal of Biomechanical Science and Engineering   4 ( 3 )   2009.7

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  • Vertical bone augmentation with fluvastatin in an injectable delivery system: a rat study. Reviewed International journal

    Jinno Y, Ayukawa Y, Ogino Y, Atsuta I, Tsukiyama Y, Koyano K.

    Clinical Oral Implants Research   20 ( 8 )   2009.5

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  • Platelet-rich plasma suppresses osteoclastogenesis by promoting the secretion of osteoprotegerin in vitro. Reviewed International journal

    Ogino Y, Ayukawa Y, Kukita T, Atsuta I, Koyano K.

    Journal of Periodontal Research   44 ( 2 )   2009.4

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  • Local application of statin promoted bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats. Reviewed International journal

    Ayukawa Y, Yasukawa E, Moriyama Y, Ogino Y, Wada H, Atsuta I, Koyano K.

    Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology   107 ( 3 )   2009.3

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  • Topical application of statin affects the bone healing around implants Reviewed International journal

    Moriyama Y, Ayukawa Y, Ogino Y, Atsuta I, Koyano K.

    Clinical Oral Implants Research   19 ( 6 )   2008.5

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  • The contribution of platelet-derived growth factor, transforming growth factor-beta1 and insulin-like growth factor-I in platelet-rich plasma (PRP) to the proliferation of osteoblast-like cells. Reviewed International journal

    2006.6

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  • The effect of platelet-rich plasma on the cellular response of rat bone marrow cells in vitro. Reviewed International journal

    Ogino Y, Ayukawa, Y, Tsukiyama Y, Koyano K.

    Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology   100 ( 3 )   302 - 307   2005.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tripleo.2005.03.007

  • Effect of the difference of bone turnover on peri-titanium implant osteogenesis in ovariectomized rats Reviewed International journal

    Okamura A, Ayukawa Y, Iyama S, Koyano K

    Journal of Biomedical Materials Research   70A ( 3 )   497 - 505   2004.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jbm.a.30110

  • Simvastatin promotes osteogenesis around titanium implants. A histological and histometrical study in rats Reviewed International journal

    Ayukawa Y, Okamura A, Koyano K

    Clinical Oral Implants Research   15 ( 3 )   346 - 350   2004.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-0501.2004.01015.x

  • Difference in penetration of horseradish peroxidase tracer as a foreign substance into the peri-implant or junctional epitherium of rat gingivae Reviewed International journal

    H. Ikeda, M. Shiraiwa, T. Yamaza, M. Yoshinari, M.A. Kido, Y. Ayukawa, T. Inoue, K. Koyano, T. Tanaka

    Clin Oral Implants Res   13 ( 3 )   243 - 251   2002.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1034/j.1600-0501.2002.130303.x

  • Ultrastructural and immunoelectron microscopic studies of the peri-implant epitherium-implant (Ti-6Al-4V) interface of rat maxilla Reviewed International journal

    H. Ikeda, T. Yamaza, M. Yoshinari, Y. Ohsaki, Y. Ayukawa, M.A. Kido, T. Inoue, M. Shimono, K. Koyano, T. Tanaka

    J Periodontol   71 ( 6 )   961 - 973   2000.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1902/jop.2000.71.6.961

  • An immunmoelectron microscopic localization of noncollagenous bone proteins (osteocalcin and osteopontin) at the bone-titanium interface Reviewed International journal

    Y. Ayukawa, F. Takeshita, T. Inoue, M. Yoshinari, M. Shimono, T. Suetsugu, T. Tanaka

    J Biomed Mater Res   41 ( 1 )   111 - 119   1998.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/(SICI)1097-4636(199807)41:1<111::AID-JBM14>3.0.CO;2-Q

  • Synergistic Effect of Nano Strontium Titanate Coating and Ultraviolet C Photofunctionalization on Osteogenic Performance and Soft Tissue Sealing of poly(ether-ether-ketone)

    Tianjie Chen, Yohei Jinno, Ikiru Atsuta, Akira Tsuchiya, Sora Obinata, Riku Iimori, Takashi Kimura, Yasunori Ayukawa

    ACS Biomaterials Science and Engineering   10 ( 2 )   825 - 837   2024.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsbiomaterials.3c01684

  • Current surface modification strategies to improve the binding efficiency of emerging biomaterial polyetheretherketone (PEEK) with bone and soft tissue: A literature review. Reviewed

    Tianjie Chen, Yohei Jinno, Ikiru Atsuta, Akira Tsuchiya, Michele Stocchero, Eriberto Bressan, Yasunori Ayukawa

    Journal of prosthodontic research   67 ( 3 )   337 - 347   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2186/jpr.JPR_D_22_00138

  • Effects of Administration Route of Parathyroid Hormone on Bone Quantity around implants in Ovariectomized Rat Maxillae(タイトル和訳中) Reviewed

    Al-Omari Farah A., 黒嶋 伸一郎, 右藤 友督, 内田 悠介, 張 暁旭, 三田 公麿, 鮎川 保則, 澤瀬 隆

    日本口腔インプラント学会誌   36 ( 1 )   E30 - E31   2023.3

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  • Impact of number of functional teeth on independence of Japanese older adults Reviewed International journal

    Geriatrics & Gerontology International   22 ( 12 )   1032 - 1039   2022.11

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ggi.14508

  • Synergistic Effect of Carbonate Apatite and Autogenous Bone on Osteogenesis Reviewed International journal

    Ikiru Atsuta, Tokihisa Mizokami, Yohei Jinno, Bin Ji, Tingyu Xie, Yasunori Ayukawa

    Materials   15 ( 22 )   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ma15228100

  • Oral Health-Related Quality of Life Changes after Clinical Remounting of Existing Dentures. Reviewed International journal

    Chi-Hsiang Cheng, Ikiru Atsuta, Kiyoshi Koyano, Yasunori Ayukawa

    Healthcare (Basel, Switzerland)   10 ( 10 )   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/healthcare10101960

  • Therapeutic Effect of Benidipine on Medication-Related Osteonecrosis of the Jaw. Reviewed International journal

    Ken Matsunaka, Mikio Imai, Koma Sanda, Noriyuki Yasunami, Akihiro Furuhashi, Ikiru Atsuta, Hiroko Wada, Yasunori Ayukawa

    Pharmaceuticals (Basel, Switzerland)   15 ( 8 )   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ph15081020

  • Primary stability of different implant macrodesigns in a sinus floor elevation simulated model: an ex vivo study. Reviewed International journal

    Mikio Imai, Yoichiro Ogino, Hideaki Tanaka, Kiyoshi Koyano, Yasunori Ayukawa, Takeshi Toyoshima

    BMC oral health   22 ( 1 )   332 - 332   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12903-022-02345-5

  • Therapeutic effect of fluvastatin on medication-related osteonecrosis of the jaw. Reviewed International journal

    Koma Sanda, Yasunori Ayukawa, Noriyuki Yasunami, Naomi Adachi, Akihiro Furuhashi, Mikio Imai, Ken Matsunaka, Kiyoshi Koyano

    Journal of periodontology   93 ( 6 )   837 - 846   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/JPER.21-0294

  • 【インプラント治療の症型分類】エビデンスに基づいたインプラント治療難易度診断ツールの開発 Invited

    鮎川 保則, 會田 英紀, 秋山 謙太郎, 大島 正充, 佐藤 洋平, 廣安 一彦, 古屋 純一, 山田 陽一, 澤瀬 隆, 窪木 拓男

    日本口腔インプラント学会誌   35 ( 2 )   83 - 91   2022.6

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    本邦では口腔外科や補綴,歯周病のいずれかに軸足を置く歯科医師がインプラント治療を担当することが多いように思われる.そのため,特に自身がメインフィールドとする領域以外の治療において正確な難易度を判定する手法があれば,安心安全なインプラント治療を提供することができると考えられる.現在,いくつかのインプラント治療難易度判定ツールが提案されているが,これまでに用いられてきた種々の分類法では難易度をうまく表現できない問題も存在する.たとえば,骨の質,量ともに問題なく咬合にも問題ない下顎臼歯部1歯中間欠損などはイージーケースといっても差し支えないと思われるが,一方で未経験者にとっては,骨をドリリングすること自体が難しく感じられるだろう.このように,ある症例が簡単か難しいかは,術者の感じ方や経験で大きく異なる.また,このような術者間で感じ方に差がある技術的難易度とは別個に,全身状態や治療部位,患者の個性に基づく難易度が存在する.これらの項目に問題がある場合にインプラント治療の成功率が低下することは,多くの場合質が高いエビデンスで裏づけされている.日本口腔インプラント学会研究推進委員会では,Evidence-Based Difficulty Assessment Toolともいえる,術者の経験によらないインプラント治療の難易度分類を試みている.本稿ではその試案を提示する.(著者抄録)

  • Hypothetical Model of How a Clinical Remount Procedure Benefits Patients with Existing Dentures: A Narrative Literature Review. Reviewed International journal

    Chi-Hsiang Cheng, Ikiru Atsuta, Kiyoshi Koyano, Yasunori Ayukawa

    Healthcare (Basel, Switzerland)   10 ( 6 )   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/healthcare10061067

  • RANKL elevation activates the NIK/NF-κB pathway, inducing obesity in ovariectomized mice. Reviewed International journal

    254 ( 1 )   27 - 36   2022.5

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    Menopausal women are susceptible to visceral obesity, which increases the risk of metabolic disorders. However, the mechanisms of menopause-induced visceral fat accumulation are not fully understood. Circulating levels of receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL) are elevated in an animal model of menopause. RANKL, a multifunctional cytokine, activates the NF-κB pathway, which serves as a pivotal mediator of inflammatory responses. Here, we investigated whether RANKL-induced non-canonical NF-κB pathway activation induces inflammation and lipid accumulation in adipose tissues. RANKL induced Tnfa expression via the non-canonical NF-κB pathway in bone marrow cells. We therefore analyzed aly/aly mice, in which the non-canonical NF-κB pathway is not activated, owing to an inactive form of NF-κB-inducing kinase. A postmenopausal obesity model was generated by ovariectomy and subsequent high-fat and high-sucrose diet feeding. In aly/aly mice with postmenopausal obesity, serum RANKL levels were elevated, and hepatic lipid accumulation and adipocyte hypertrophy were suppressed, resulting in reduced macrophage infiltration and inflammatory cytokine mRNA expression in visceral adipose tissue. Furthermore, aly/aly mice showed protection from glucose intolerance and insulin resistance, which were observed in ovariectomized WT obese mice. These findings indicate that non-canonical NF-κB pathway activation via serum RANKL elevation contributes to postmenopausal obesity.

    DOI: 10.1530/JOE-21-0424

  • Oral Function Rehabilitation with the Simplified Lauritzen Clinical Remount Technique in a Patient with Bimaxillary Alveolar Exostoses: A Case Report. Reviewed International journal

    Chi-Hsiang Cheng, Ikiru Atsuta, Yuki Egashira, Kiyoshi Koyano, Yasunori Ayukawa

    Healthcare (Basel, Switzerland)   10 ( 4 )   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/healthcare10040682

  • Effect of carbonate apatite as a bone substitute on oral mucosal healing in a rat extraction socket: in vitro and in vivo analyses using carbonate apatite. Reviewed International journal

    Yuki Egashira, Ikiru Atsuta, Ikue Narimatsu, Xiaoxu Zhang, Ryosuke Takahashi, Kiyoshi Koyano, Yasunori Ayukawa

    International journal of implant dentistry   8 ( 1 )   11 - 11   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40729-022-00408-4

  • インプラント治療は高齢者の残存歯を守りQOLを高めるか? Invited

    窪木 拓男, 黒崎 陽子, 大野 彩, 三野 卓哉, 荒川 光, 小山 絵理, 中川 晋輔, Ha Thi Thu Nguyen, 逢坂 卓, 佐伯 真未子, 水口 一, 大野 充昭, 前川 賢治, 會田 英紀, 澤瀬 隆, 鮎川 保則, 秋山 謙太郎, 大島 正充, 佐藤 裕二, 佐藤 洋平, 廣安 一彦, 山田 陽一, 阪本 貴司, 宮崎 隆, 日本口腔インプラント学会研究推進委員会

    8020: はち・まる・にい・まる   2020 ( 21 )   153 - 155   2022.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    インプラント治療後の残存歯および口腔関連QOLを他の歯科補綴治療との比較から明らかにすることを目的に、過去にインプラント義歯(IP)、ブリッジ(BR)、床義歯(RPD)治療前後に口腔関連QOL評価を受けた患者105名(IP群58名、BR群27名、RPD群20名)を対象に、6年経過後の追跡調査時における対象補綴装置の6年累積生存率、残存歯数、および口腔関連QOLを評価した。その結果、6年累積生存率はIP群94.7%、BR群77.4%、RPD群33.3%で、IP群は他の2群に比べ有意に高かった。追跡調査時の残存歯数については、IP群がRPD群に比べ有意に多かった。また、口腔関連QOLについては、IP群では治療開始前後、および治療前・追跡調査時のいずれにおいても有意に高くなっていたのに対し、他の2群ではいずれも有意差は認めなかった。

  • Influence of osteoporosis and mechanical loading on bone around osseointegrated dental implants: A rodent study. Reviewed International journal

    Xi Chen, Yasuko Moriyama, Yoko Takemura, Maho Rokuta, Yasunori Ayukawa

    Journal of the mechanical behavior of biomedical materials   123   104771 - 104771   2021.11

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    DOI: 10.1016/j.jmbbm.2021.104771

  • Staged Sinus Floor Elevation Using Novel Low-Crystalline Carbonate Apatite Granules: Prospective Results after 3-Year Functional Loading. Reviewed International journal

    Yoichiro Ogino, Yasunori Ayukawa, Noriko Tachikawa, Masahiro Shimogishi, Youji Miyamoto, Keiko Kudoh, Naoyuki Fukuda, Kunio Ishikawa, Kiyoshi Koyano

    Materials (Basel, Switzerland)   14 ( 19 )   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ma14195760

  • Masticatory performance and other oral functions in community-dwelling elderly patients without posterior occlusal support by natural teeth. Reviewed

    Yoichiro Ogino, Hiroki Suzuki, Yasunori Ayukawa, Yoko Ueno, Akio Jinnouchi, Kiyoshi Koyano

    Journal of oral science   63 ( 4 )   330 - 333   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2334/josnusd.21-0265

  • Clinical effectiveness of implant support for distal extension removable partial dentures: functional evaluation using occlusal force measurement and masticatory efficiency. Reviewed International journal

    Kei Murakami, Yasunori Ayukawa, Yoichiro Ogino, Akinari Nakagawa, Tadashi Horikawa, Eishi Yamaguchi, Kimiyasu Takaki, Kiyoshi Koyano

    International journal of implant dentistry   7 ( 1 )   101 - 101   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40729-021-00381-4

  • Accuracy of the Intra- and Extra-Oral Scanning Technique for Transferring the Intaglio Surface of a Pontic of Provisional Restorations to Definitive Restorations. Reviewed International journal

    Koma Sanda, Noriyuki Yasunami, Maki Okada, Akihiro Furuhashi, Yasunori Ayukawa

    Materials (Basel, Switzerland)   14 ( 21 )   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ma14216489

  • Analyses of Swallowing Function and Its Related Factors in Community-Dwelling Elderly Patients: A Case-Control Study. Reviewed International journal

    Yoichiro Ogino, Hiroki Suzuki, Yasunori Ayukawa, Akio Jinnouchi, Kiyoshi Koyano

    Journal of clinical medicine   10 ( 15 )   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/jcm10153437

  • Replacement Process of Carbonate Apatite by Alveolar Bone in a Rat Extraction Socket Reviewed International journal

    Xiaoxu Zhang, Ikiru Atsuta, Ikue Narimatsu, Nobuyuki Ueda, Ryosuke Takahashi, Yuki Egashira, Jing-Qi Zhang, Jiong-Yan Gu, Kiyoshi Koyano, Yasunori Ayukawa

    Materials   14 ( 16 )   4457 - 4457   2021.8

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    DOI: 10.3390/ma14164457

  • Assessment of the Soft-Tissue Seal at the Interface between the Base of the Fixed Denture Pontic and the Oral Mucosa. Reviewed International journal

    Ikiru Atsuta, Ikue Narimatsu, Taichiro Morimoto, Chi-Hsiang Cheng, Kiyoshi Koyano, Yasunori Ayukawa

    Materials (Basel, Switzerland)   14 ( 14 )   2021.7

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    DOI: 10.3390/ma14143997

  • A Prospective Comparative Study of Mastication Predominance and Masticatory Performance in Kennedy Class I Patients. Reviewed International journal

    Kohei Kinoshita, Yoichiro Ogino, Kyosuke Oki, Yo Yamasaki, Yoshihiro Tsukiyama, Yasunori Ayukawa, Kiyoshi Koyano

    Healthcare (Basel, Switzerland)   9 ( 6 )   2021.6

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    DOI: 10.3390/healthcare9060660

  • The Significance of Posterior Occlusal Support of Teeth and Removable Prostheses in Oral Functions and Standing Motion. Reviewed International journal

    Kyosuke Oki, Yoichiro Ogino, Yuriko Takamoto, Mikio Imai, Yoko Takemura, Yasunori Ayukawa, Kiyoshi Koyano

    International journal of environmental research and public health   18 ( 13 )   2021.6

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    DOI: 10.3390/ijerph18136776

  • Soft Tissue Interface with Various Kinds of Implant Abutment Materials. Reviewed International journal

    Akihiro Furuhashi, Yasunori Ayukawa, Ikiru Atsuta, Yunia Dwi Rakhmatia, Kiyoshi Koyano

    Journal of clinical medicine   10 ( 11 )   2021.5

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    DOI: 10.3390/jcm10112386

  • The need for polishing and occlusal adjustment of zirconia prostheses for wear on antagonist teeth. Reviewed

    Keishu Tachibana, Ikiru Atsuta, Yoshihiro Tsukiyama, Rika Kuwatsuru, Takehiro Morita, Hiroya Yoshimatsu, Yasuyuki Matsushita, Ikue Narimatsu, Yasunori Ayukawa, Yoshinori Sawae, Kiyoshi Koyano

    Dental materials journal   40 ( 3 )   650 - 656   2021.5

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    DOI: 10.4012/dmj.2020-190

  • In Vitro Assessment of the Effect of Implant Position on Biomechanical Behaviors of Implant-Supported Removable Partial Dentures in Kennedy Class II Condition. Reviewed International journal

    Masafumi Kihara, Yoichiro Ogino, Yasuyuki Matsushita, Takehiro Morita, Yoshinori Sawae, Yasunori Ayukawa, Kiyoshi Koyano

    Materials (Basel, Switzerland)   14 ( 9 )   2021.4

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    DOI: 10.3390/ma14092145

  • ラット抜歯窩の治癒過程から見る炭酸アパタイト製骨補填材の有効性 Reviewed

    張 暁旭, 熱田 生, 鮎川 保則, 成松 生枝, 上田 将之, 高橋 良輔, 江頭 優希, 張 旌旗, 顧 炯炎, 古谷野 潔

    日本歯科理工学会誌   39 ( Special Issue76 )   38 - 38   2020.12

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  • Relationship between Maximum Tongue Pressure Value and Age, Occlusal Status, or Body Mass Index among the Community-Dwelling Elderly. Reviewed International journal

    Hiroki Suzuki, Yasunori Ayukawa, Yoko Ueno, Ikiru Atsuta, Akio Jinnouchi, Kiyoshi Koyano

    Medicina (Kaunas, Lithuania)   56 ( 11 )   2020.11

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    DOI: 10.3390/medicina56110623

  • Localization of Integrin Beta-4 Subunit at Soft Tissue-Titanium or Zirconia Interface. Reviewed International journal

    Yasunori Ayukawa, Ikiru Atsuta, Yasuko Moriyama, Yohei Jinno, Kiyoshi Koyano

    Journal of clinical medicine   9 ( 10 )   2020.10

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    DOI: 10.3390/jcm9103331

  • Factors associated with discontinuation and resumption of implant maintenance therapy. Reviewed International journal

    Chika Arimizu, Yasunori Ayukawa, Rika Kuwatsuru, Satoru Haresaku, Yasuyuki Matsushita, Kiyoshi Koyano

    Journal of oral science   62 ( 4 )   356 - 359   2020.9

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    DOI: 10.2334/josnusd.19-0318

  • 炭酸アパタイト製骨補填材が口腔粘膜の治癒に及ぼす影響について Invited Reviewed

    熱田 生, 江頭 優希, 鮎川 保則, 成松 生枝, 張 暁旭, 杉 友貴, 高橋 良輔, 古谷野 潔

    日本口腔インプラント学会誌   33 ( 特別号 )   307 - 307   2020.9

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  • ラット抜歯モデルを用いた炭酸アパタイト製骨補填材の有用性の検討

    張 暁旭, 熱田 生, 鮎川 保則, 成松 生枝, 上田 将之, 張 旌旗, 顧 炯炎, 古谷野 潔

    日本口腔インプラント学会誌   33 ( 特別号 )   331 - 331   2020.9

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  • The impact of surface alteration on epithelial tissue attachment after the mechanical cleaning of titanium or zirconia surface. Reviewed International journal

    Jiangqi Hu, Ikiru Atsuta, Yasunori Ayukawa, Xudiyang Zhou, Yunia Dwi Rakhmatia, Kiyoshi Koyano

    Journal of oral rehabilitation   47 ( 9 )   1065 - 1076   2020.9

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    DOI: 10.1111/joor.12920

  • Effect of Calcium Chloride Hydrothermal Treatment of Titanium on Protein, Cellular, and Bacterial Adhesion Properties Reviewed International journal

    Takuya Haraguchi, Yasunori Ayukawa, Yukie Shibata, Toru Takeshita, Ikiru Atsuta, Yoichiro Ogino, Noriyuki Yasunami, Yoshihisa Yamashita, Kiyoshi Koyano

    Journal of Clinical Medicine   9 ( 8 )   2020.8

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    DOI: 10.3390/jcm9082627

  • Effect of titanium or zirconia implant abutments on epithelial attachments after ultrasonic cleaning Reviewed International journal

    Jiangqi Hu, Ikiru Atsuta, Yasunori Ayukawa, Tianren Zhou, Ikue Narimatsu, Kiyoshi Koyano

    Journal of Oral Science   62 ( 3 )   331 - 334   2020.7

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    DOI: 10.2334/josnusd.19-0332

  • Number of functional teeth more strongly predicts all-cause mortality than number of present teeth in Japanese older adults. Reviewed

    Kenji Maekawa, Tomoko Ikeuchi, Shoji Shinkai, Hirohiko Hirano, Masahiro Ryu, Katsushi Tamaki, Hirofumi Yatani, Takuo Kuboki, Aya Kimura-Ono, Takeshi Kikutani, Takashi Suganuma, Yasunori Ayukawa, Tomoya Gonda, Toru Ogawa, Masanori Fujisawa, Shoichi Ishigaki, Yutaka Watanabe, Akihiko Kitamura, Yu Taniguchi, Yoshinori Fujiwara, Ayako Edahiro, Yuki Ohara, Junichi Furuya, Junko Nakajima, Kento Umeki, Kentaro Igarashi, Yasuhiro Horibe, Yoshihiro Kugimiya, Yasuhiko Kawai, Hideo Matsumura, Tetsuo Ichikawa, Shuji Ohkawa

    Geriatrics & gerontology international   20 ( 6 )   607 - 614   2020.6

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    DOI: 10.1111/ggi.13911

  • Effects of different divalent cation hydrothermal treatments of titanium implant surfaces for epithelial tissue sealing Reviewed

    Xudiyang Zhou, Ikiru Atsuta, Yasunori Ayukawa, Ikue Narimatsu, Tianren Zhou, Jiangqi Hu, Kiyoshi Koyano

    Materials   13 ( 9 )   2020.5

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    DOI: 10.3390/MA13092038

  • Preventive effect of fluvastatin on the development of medication-related osteonecrosis of the jaw. Reviewed International journal

    Naomi Adachi, Yasunori Ayukawa, Noriyuki Yasunami, Akihiro Furuhashi, Mikio Imai, Koma Sanda, Ikiru Atsuta, Kiyoshi Koyano

    Scientific reports   10 ( 1 )   5620 - 5620   2020.3

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    DOI: 10.1038/s41598-020-61724-6

  • 学生技能コンペティション「第1回JPS student clinical skills competition」 Reviewed

    峯 篤史, 疋田 一洋, 高場 雅之, 澤瀬 隆, 山下 秀一郎, 榎並 裕美子[田中], 鮎川 保則, 上田 貴之, 江草 宏, 馬場 俊輔, 笛木 賢治, 槙原 絵理, 横山 紗和子, 大川 周治, 馬場 一美, 市川 哲雄, 日本補綴歯科学会学術委員会

    日本補綴歯科学会誌   12 ( 1 )   5 - 15   2020.1

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    (公社)日本補綴歯科学会は、全国の歯学部学生を対象とした臨床技能コンペティション(課題:保険収載CAD/CAM冠を想定した支台歯形成、下顎右側第二小臼歯)を開催した。26校の代表者各1名が行った支台歯形成を審査し、上位6名の学生を選出した。これらの学生を対象としたオンサイトでの最終実技審査を行い、審査結果の公表および優秀者の表彰を同日に行った。審査は形成模型のデジタルスキャンデータを使用して算出されたテーパーと削除量を参考に、評価者による総括評価とした。事後アンケートでは肯定的な回答が寄せられ、特に参加学生にとって本企画が歯科技能向上に対する研鑽意欲を喚起するものであったことが明らかになった。(著者抄録)

  • Novel application method for mesenchymal stem cell therapy utilizing its attractant-responsive accumulation property Reviewed

    Nobuyuki Ueda, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Akihiro Furuhashi, Ikue Narimatsu, Yuri Matsuura, Ryosuke Kondo, Yu Watanabe, Xiaoxu Zhang, Kiyoshi Koyano

    Applied Sciences (Switzerland)   9 ( 22 )   2019.11

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    DOI: 10.3390/app9224908

  • Effect of post-osseointegration loading magnitude on the dynamics of peri-implant bone a finite element analysis and in vivo study Reviewed

    Tatsuya Matsuzaki, Yasunori Ayukawa, Yasuyuki Matsushita, Nobuo Sakai, Maki Matsuzaki, Tomohiro Masuzaki, Takuya Haraguchi, Yoichiro Ogino, Kiyoshi Koyano

    Journal of Prosthodontic Research   63 ( 4 )   453 - 459   2019.10

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    DOI: 10.1016/j.jpor.2018.10.009

  • Injectable Porous Bioresorbable Composite Containing Fluvastatin for Bone Augmentation. International journal

    Tianren Zhou, Yasuko Moriyama, Yasunori Ayukawa, Yunia Dwi Rakhmatia, Xudiyang Zhou, Jiangqi Hu, Kiyoshi Koyano

    ACS biomaterials science & engineering   5 ( 10 )   5422 - 5429   2019.10

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    DOI: 10.1021/acsbiomaterials.9b01045

  • Epithelial and Connective Tissue Sealing around Titanium Implants with Various Typical Surface Finishes. International journal

    Ikue Narimatsu, Ikiru Atsuta, Yasunori Ayukawa, Wakana Oshiro, Noriyuki Yasunami, Akihiro Furuhashi, Kiyoshi Koyano

    ACS biomaterials science & engineering   5 ( 10 )   4976 - 4984   2019.10

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    DOI: 10.1021/acsbiomaterials.9b00499

  • Effect of post-osseointegration loading magnitude on the dynamics of peri-implant bone: a finite element analysis and in vivo study. Reviewed

    Tatsuya Matsuzaki, Yasunori Ayukawa, Yasuyuki Matsushita, Nobuo Sakai, Maki Matsuzaki, Tomohiro Masuzaki, Takuya Haraguchi, Yoichiro Ogino, Kiyoshi Koyano

    Journal of prosthodontic research   63 ( 4 )   453 - 459   2019.10

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    DOI: 10.1016/j.jpor.2018.10.009

  • Injectable Porous Bioresorbable Composite Containing Fluvastatin for Bone Augmentation Reviewed International journal

    Tianren Zhou, Yasuko Moriyama, Yasunori Ayukawa, Yunia Dwi Rakhmatia, Xudiyang Zhou, Jiangqi Hu, Kiyoshi Koyano

    ACS Biomaterials Science and Engineering   5 ( 10 )   5422 - 5429   2019.10

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    DOI: 10.1021/acsbiomaterials.9b01045

  • Long Term Retention of Gingival Sealing around Titanium Implants with CaCl2 Hydrothermal Treatment: A Rodent Study. International journal

    Yasunori Ayukawa, Wakana Oshiro, Ikiru Atsuta, Akihiro Furuhashi, Ryosuke Kondo, Yohei Jinno, Kiyoshi Koyano

    Journal of clinical medicine   8 ( 10 )   2019.9

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    DOI: 10.3390/jcm8101560

  • Long Term Retention of Gingival Sealing around Titanium Implants with CaCl2 Hydrothermal Treatment A Rodent Study Reviewed

    Yasunori Ayukawa, Wakana Oshiro, Ikiru Atsuta, Akihiro Furuhashi, Ryosuke Kondo, Yohei Jinno, Kiyoshi Koyano

    Journal of Clinical Medicine   8 ( 10 )   2019.9

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    DOI: 10.3390/jcm8101560

  • Effect of Hydrothermal Treatment with Distilled Water on Titanium Alloy for Epithelial Cellular Attachment. International journal

    Yasushige Sakamoto, Yasunori Ayukawa, Akihiro Furuhashi, Michimasa Kamo, Junji Ikeda, Ikiru Atsuta, Takuya Haraguchi, Kiyoshi Koyano

    Materials (Basel, Switzerland)   12 ( 17 )   2019.8

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    DOI: 10.3390/ma12172748

  • Epithelial sealing effectiveness against titanium or zirconia implants surface. International journal

    Ikiru Atsuta, Yasunori Ayukawa, Akihiro Furuhashi, Ikue Narimatsu, Ryosuke Kondo, Wakana Oshiro, Kiyoshi Koyano

    Journal of biomedical materials research. Part A   107 ( 7 )   1379 - 1385   2019.7

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    DOI: 10.1002/jbm.a.36651

  • Investigation of a novel sterilization method for biofilms formed on titanium surfaces.

    Rei Nagao, Daisuke Esaki, Yukie Shibata, Satoshi Ikawa, Katsuhisa Kitano, Yasunori Ayukawa, Yasuyuki Matsushita, Toru Takeshita, Yoshihisa Yamashita, Masaaki Matsuzaki, Kiyoshi Koyano

    Dental materials journal   38 ( 4 )   654 - 662   2019.7

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    DOI: 10.4012/dmj.2018-274

  • 口腔粘膜上皮はブリッジのポンティック底部に対して接着性を有するか?

    熱田 生, 鮎川 保則, 森本 太一朗, 古橋 明大, 成松 生枝, 古谷野 潔

    日本補綴歯科学会誌   11 ( 特別号 )   252 - 252   2019.5

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  • ベニジピン含有マイクロスフィア単回投与が抜歯窩の骨および歯肉の治癒におよぼす影響

    今井 実喜生, 鮎川 保則, 安波 礼之, 古橋 明大, 冨田 陽子, 足立 奈織美, 森山 泰子, 熱田 生, 古谷野 潔

    日本補綴歯科学会誌   11 ( 特別号 )   268 - 268   2019.5

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  • Mechanical loading induced osteocyte apoptosis and connexin 43 expression in three-dimensional cell culture and dental implant model Reviewed

    Yoko Takemura, Yasuko Moriyama, Yasunori Ayukawa, Kosaku Kurata, Yunia D. Rakhmatia, Kiyoshi Koyano

    Journal of Biomedical Materials Research - Part A   107 ( 4 )   815 - 827   2019.4

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    DOI: 10.1002/jbm.a.36597

  • Mechanical loading induced osteocyte apoptosis and connexin 43 expression in three-dimensional cell culture and dental implant model. International journal

    Yoko Takemura, Yasuko Moriyama, Yasunori Ayukawa, Kosaku Kurata, Yunia D Rakhmatia, Kiyoshi Koyano

    Journal of biomedical materials research. Part A   107 ( 4 )   815 - 827   2019.4

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    DOI: 10.1002/jbm.a.36597

  • Effect of a Single Injection of Benidipine-Impregnated Biodegradable Microcarriers on Bone and Gingival Healing at the Tooth Extraction Socket Reviewed

    Mikio Imai, Yasunori Ayukawa, Noriyuki Yasunami, Akihiro Furuhashi, Yoko Takemura, Naomi Adachi, Jiangqi Hu, Xudiyang Zhou, Yasuko Moriyama, Atsuta Ikiru, Kosaku Kurata, Kiyoshi Koyano

    Advances in Wound Care   8 ( 3 )   108 - 117   2019.3

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    DOI: 10.1089/wound.2018.0834

  • Epithelial sealing effectiveness against titanium or zirconia implants surface Reviewed

    Atsuta Ikiru, Yasunori Ayukawa, Akihiro Furuhashi, Ikue Narimatsu, Ryosuke Kondo, Wakana Oshiro, Kiyoshi Koyano

    Journal of Biomedical Materials Research - Part A   2019.1

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    DOI: 10.1002/jbm.a.36651

  • Effect of hydrothermal treatment with distilled water on titanium alloy for epithelial cellular attachment Reviewed

    Yasushige Sakamoto, Yasunori Ayukawa, Akihiro Furuhashi, Michimasa Kamo, Junji Ikeda, Ikiru Atsuta, Takuya Haraguchi, Kiyoshi Koyano

    Materials   12 ( 7 )   2019.1

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    DOI: 10.3390/ma12172748

  • Generation and histomorphometric evaluation of a novel fluvastatin-containing poly(lactic-co-glycolic acid) membrane for guided bone regeneration Reviewed

    Haomiao Zhang, Yasuko Moriyama, Yasunori Ayukawa, Yunia Dwi Rakhmatia, Yoko Takemura, Noriyuki Yasunami, Kiyoshi Koyano

    Odontology   107 ( 1 )   37 - 45   2019.1

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    DOI: 10.1007/s10266-018-0376-z

  • Epithelial and Connective Tissue Sealing around Titanium Implants with Various Typical Surface Finishes Reviewed

    Ikue Narimatsu, Ikiru Atsuta, Yasunori Ayukawa, Wakana Oshiro, Noriyuki Yasunami, Akihiro Furuhashi, Kiyoshi Koyano

    ACS Biomaterials Science and Engineering   2019.1

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    DOI: 10.1021/acsbiomaterials.9b00499

  • Generation and histomorphometric evaluation of a novel fluvastatin-containing poly(lactic-co-glycolic acid) membrane for guided bone regeneration.

    Haomiao Zhang, Yasuko Moriyama, Yasunori Ayukawa, Yunia Dwi Rakhmatia, Yoko Tomita, Noriyuki Yasunami, Kiyoshi Koyano

    Odontology   107 ( 1 )   37 - 45   2019.1

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    DOI: 10.1007/s10266-018-0376-z

  • Investigation of a novel sterilization method for biofilms formed on titanium surfaces Reviewed

    Rei Nagao, Daisuke Esaki, Yukie Shibata, Satoshi Ikawa, Katsuhisa Kitano, Yasunori Ayukawa, Yasuyuki Matsushita, Toru Takeshita, Yoshihisa Yamashita, Masaaki Matsuzaki, Kiyoshi Koyano

    dental materials journal   38 ( 4 )   654 - 662   2019.1

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    DOI: 10.4012/dmj.2018-274

  • 組織再生と細胞・足場・生理活性物質

    鮎川 保則, 熱田 生, 古谷野 潔

    顎顔面補綴   41 ( 2 )   46 - 50   2018.12

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  • The Influence Of Topographical And Chemical Properties Of Dental Implants On Soft Tissue Integration. International journal

    Yasunori Ayukawa

    Journal of Indian Prosthodontic Society   18 ( Suppl 1 )   S5   2018.10

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    DOI: 10.4103/0972-4052.244585

  • A peptide that blocks the interaction of NF-B p65 subunit with Smad4 enhances BMP2-induced osteogenesis Reviewed International journal

    Urata Mariko, Kokabu Shoichiro, Matsubara Takuma, Sugiyama Goro, Nakatomi Chihiro, Takeuchi Hiroshi, Hirata-Tsuchiya Shizu, Aoki Kazuhiro, Tamura Yukihiko, Moriyama Yasuko, Ayukawa Yasunori, Matsuda Miho, Zhang Min, Koyano Kiyoshi, Kitamura Chiaki, Jimi Eijiro

    JOURNAL OF CELLULAR PHYSIOLOGY   233 ( 9 )   7356 - 7366   2018.9

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    A peptide that blocks the interaction of NF-B p65 subunit with Smad4 enhances BMP2-induced osteogenesis
    Bone morphogenetic protein (BMP) potentiates bone formation through the Smad signaling pathway in vitro and in vivo. The transcription factor nuclear factor κB (NF-κB) suppresses BMP-induced osteoblast differentiation. Recently, we identified that the transactivation (TA) 2 domain of p65, a main subunit of NF-κB, interacts with the mad homology (MH) 1 domain of Smad4 to inhibit BMP signaling. Therefore, we further attempted to identify the interacting regions of these two molecules at the amino acid level. We identified a region that we term the Smad4-binding domain (SBD), an amino-terminal region of TA2 that associates with the MH1 domain of Smad4. Cell-permeable SBD peptide blocked the association of p65 with Smad4 and enhanced BMP2-induced osteoblast differentiation and mineralization without affecting the phosphorylation of Smad1/5 or the activation of NF-κB signaling. SBD peptide enhanced the binding of the BMP2-inudced phosphorylated Smad1/5 on the promoter region of inhibitor of DNA binding 1 (Id-1) compared with control peptide. Although SBD peptide did not affect BMP2-induced chondrogenesis during ectopic bone formation, the peptide enhanced BMP2-induced ectopic bone formation in subcortical bone. Thus, the SBD peptide is useful for enabling BMP2-induced bone regeneration without inhibiting NF-κB activity.

    DOI: 10.1002/jcp.26571

  • アスピリンを用いたインプラント周囲上皮封鎖性に対する間葉系幹細胞効果の増強

    熱田 生, 鮎川 保則, 近藤 綾介, 松浦 由梨, 古橋 明大, 成松 生枝, 上田 将之, 古谷野 潔

    日本口腔インプラント学会誌   31 ( 3 )   E181 - E182   2018.9

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  • Carbonate apatite containing statin enhances bone formation in healing incisal extraction sockets in rats Reviewed

    Yunia Dwi Rakhmatia, Yasunori Ayukawa, Akihiro Furuhashi, Kiyoshi Koyano

    Materials   11 ( 7 )   2018.7

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    DOI: 10.3390/ma11071201

  • Influence of the wettability of different titanium surface topographies on initial cellular behavior.

    Tomoko Nishimura, Yoichiro Ogino, Yasunori Ayukawa, Kiyoshi Koyano

    Dental materials journal   37 ( 4 )   650 - 658   2018.7

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    DOI: 10.4012/dmj.2017-334

  • Carbonate Apatite Containing Statin Enhances Bone Formation in Healing Incisal Extraction Sockets in Rats. International journal

    Yunia Dwi Rakhmatia, Yasunori Ayukawa, Akihiro Furuhashi, Kiyoshi Koyano

    Materials (Basel, Switzerland)   11 ( 7 )   2018.7

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    DOI: 10.3390/ma11071201

  • The effective design of zirconia coping on titanium base in dental implant superstructure. Reviewed International journal

    #Mieda M, Atsuta I, Morita T, Ayukawa Y, Tsukiyama Y, Sawae Y, Koyano K.

    Dent Mater J   2018.6

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  • The influence of implant—abutment connection on the screw loosening and microleakage Reviewed International journal

    4   2018.6

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  • Generation and histomorphometric evaluation of a novel fluvastatin-containing poly(lactic-co-glycolic acid) membrane for guided bone regeneration Reviewed International journal

    2018.6

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  • The influence of implant-abutment connection on the screw loosening and microleakage. International journal

    Katsuhiro Tsuruta, Yasunori Ayukawa, Tatsuya Matsuzaki, Masafumi Kihara, Kiyoshi Koyano

    International journal of implant dentistry   4 ( 1 )   11 - 11   2018.4

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    DOI: 10.1186/s40729-018-0121-y

  • The influence of systemically or locally administered mesenchymal stem cells on tissue repair in a rat oral implantation model Reviewed International journal

    #Kanazawa M,Atsuta I,Ayukawa Y,Yamaza T,Kondo R,Matsuura Y,Koyano K

    International Journal of Implant Dentistry   4   2018.1

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  • The influence of systemically or locally administered mesenchymal stem cells on tissue repair in a rat oral implantation model. International journal

    Miya Kanazawa, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Ryosuke Kondo, Yuri Matsuura, Kiyoshi Koyano

    International journal of implant dentistry   4 ( 1 )   2 - 2   2018.1

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    DOI: 10.1186/s40729-017-0112-4

  • The effective design of zirconia coping on titanium base in dental implant superstructure Reviewed

    Maiko Mieda, Ikiru Atsuta, Yasuyuki Matsushita, Takehiro Morita, Yasunori Ayukawa, Yoshihiro Tsukiyama, Yoshinori Sawae, Kiyoshi Koyano

    dental materials journal   37 ( 2 )   237 - 243   2018.1

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    DOI: 10.4012/dmj.2017-022

  • Influence of the wettability of different titanium surface topographies on initial cellular behavior Reviewed

    Tomoko Nishimura, Yoichiro Ogino, Yasunori Ayukawa, Kiyoshi Koyano

    dental materials journal   37 ( 4 )   650 - 658   2018.1

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    DOI: 10.4012/dmj.2017-334

  • A peptide that blocks the interaction of NF-κB p65 subunit with Smad4 enhances BMP2-induced osteogenesis Invited Reviewed International journal

    233   7356 - 7366   2018.1

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    DOI: 10.1002/jcp.26571

  • Single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis Reviewed

    Norio Goto, Ken Okazaki, Yukio Akasaki, Kohei Ishihara, Koji Murakami, Kiyoshi Koyano, Yasunori Ayukawa, Noriyuki Yasunami, Tomohiro Masuzaki, Yasuharu Nakashima

    Journal of Orthopaedic Research   35 ( 11 )   2465 - 2475   2017.11

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    DOI: 10.1002/jor.23562

  • Single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis Reviewed International journal

    Norio Goto, Ken Okazaki, Yukio Akasaki, Kohei Ishihara, Koji Murakami, Kiyoshi Koyano, Yasunori Ayukawa, Noriyuki Yasunami, Tomohiro Masuzaki, Yasuharu Nakashima

    JOURNAL OF ORTHOPAEDIC RESEARCH   35 ( 11 )   2465 - 2475   2017.11

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    DOI: 10.1002/jor.23562

  • Micro-computed tomography analysis of early stage bone healing using micro-porous titanium mesh for guided bone regeneration: preliminary experiment in a canine model Reviewed

    Yunia Dwi Rakhmatia, Yasunori Ayukawa, Yohei Jinno, Akihiro Furuhashi, Kiyoshi Koyano

    ODONTOLOGY   105 ( 4 )   408 - 417   2017.10

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    DOI: 10.1007/s10266-017-0298-1

  • インプラント周囲組織における生物学的幅径および軟組織封鎖性の検討

    成松 生枝, 鮎川 保則, 熱田 生, 大城 和可奈, 安波 礼之, 古橋 明大, 古谷野 潔

    日本補綴歯科学会誌   9 ( 特別号 )   213 - 213   2017.6

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  • A comparison of the peri-implant bone stress generated by the preload with screw tightening between ‘bonded’ and ‘contact’ model Reviewed

    20 ( 4 )   393 - 402   2017.3

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    A number of finite element analyses (FEAs) for the dental implant were performed without regard for preload and with all interfaces ‘fixed-bonded’. The purpose of this study was comparing the stress distributions between the conventional FEA model with all contacting interfaces ‘fixed-bonded’ (bonded model) and the model with the interfaces of the components in ‘contact’ with friction simulated as a preloaded implant (contact model). We further verified the accuracy of the result of the FEA using model experiment. In the contact model, the stress was more widely distributed than in the bonded model. From the model study, the preload induced by screw tightening generated strain at the peri-implant bone, even before the application of external force. As a result, the bonded model could not reproduce the mechanical phenomena, whereas the contact model is considered to be appropriate for analysing mechanical problems.

    DOI: 10.1080/10255842.2016.1236370

  • Tissue reaction to a novel bone substitute material fabricated with biodegradable polymer-calcium phosphate nanoparticle composite Invited Reviewed International journal

    Hideo Shimizu, Yohei Jinno, Yasunori Ayukawa, Ikiru Atsuta, Takaaki Arahira, Mitsugu Todo, Kiyoshi Koyano

    Implant Dentistry   ( in press )   2016.10

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  • Medication-related osteonecrosis of the jaw; what should we do as prosthodontists?

    Shinichiro Kuroshima, Masaru Kaku, Takashi Matsuura, Ikiru Atsuta, Yasunori Ayukawa, Takashi Sawase

    Journal of prosthodontic research   60 ( 4 )   229 - 230   2016.10

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    DOI: 10.1016/j.jpor.2016.01.004

  • Medication-Related Osteonecrosis of the Jaw; What Should We Do as Prosthodontists? Invited Reviewed International journal

    Shinichiro Kuroshima, Masaru Kaku, Takashi Matsuura, Ikiru Atsuta, Yasunori Ayukawa, Takashi Sawase

    Journal of Prosthodontic Research   in press   2016.10

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  • A comparison of the peri-implant bone stress generated by the preload with screw tightening between 'bonded' and 'contact' model. Invited Reviewed International journal

    Matsuzaki M, Ayukawa Y, Sakai N, Matsuzaki T, Yasuyuki Matsushita, Koyano K

    Computer methods in biomechanics and biomedical engineering   20   393 - 402   2016.9

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  • Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw Reviewed

    Yuri Matsuura, Atsuta Ikiru, Yasunori Ayukawa, Takayoshi Yamaza, Ryosuke Kondo, akira takahashi, Nobuyuki Ueda, Wakana Oshiro, Yoshihiro Tsukiyama, Kiyoshi Koyano

    Stem Cell Research and Therapy   7 ( 1 )   2016.8

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    DOI: 10.1186/s13287-016-0367-3

  • Tissue Reaction to a Novel Bone Substitute Material Fabricated With Biodegradable Polymer-Calcium Phosphate Nanoparticle Composite. Reviewed International journal

    Shimizu H, Jinno Y, Ayukawa Y, Atsuta I, Arahira T, Todo M, Koyano K

    Implant dentistry   25 ( 5 )   567 - 574   2016.8

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    Tissue Reaction to a Novel Bone Substitute Material Fabricated With Biodegradable Polymer-Calcium Phosphate Nanoparticle Composite.
    PURPOSE: The aim of this study was to evaluate the effectiveness of a novel bone substitute material fabricated using a biodegradable polymer-calcium phosphate nanoparticle composite. METHODS: Porous structured poly-L-lactic acid (PLLA) and hydroxyapatite (HA) nanoparticle composite, which was fabricated using solid-liquid phase separation and freeze-drying methods, was grafted into bone defects created in rat calvarium or tibia. Rats were killed 4 weeks after surgery, and histological analyses were performed to evaluate new bone formation. RESULTS: Scanning electron microscopic observation showed the interconnecting pores within the material and the pore diameter was approximately 100 to 300 μm. HA nanoparticles were observed to be embedded into the PLLA beams. In the calvarial implantation model, abundant blood vessels and fibroblastic cells were observed penetrating into pores, and in the tibia model, newly formed bone was present around and within the composite. CONCLUSIONS: The PLLA-HA nanoparticle composite bone substitute developed in this study showed biocompatibility, elasticity, and operability and thus has potential as a novel bone substitute.

    DOI: 10.1097/ID.0000000000000447

  • Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw. Reviewed International journal

    Matsuura Y, Atsuta I, Ayukawa Y, Yamaza T, Kondo R, Takahashi A, Ueda N, Oshiro W, Tsukiyama Y, Koyano K

    Stem cell research & therapy   7 ( 1 )   119 - 119   2016.8

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    Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw.
    BACKGROUND: Mesenchymal stem cells (MSCs) have been isolated from a variety of tissues, including bone marrow, adipose, and mucosa. MSCs have the capacity for self-renewal and differentiation. Reports have been published on the systemic administration of MSCs leading to functional improvements by engraftment and differentiation, thus providing a new strategy to regenerate damaged tissues. Recently, it has become clear that MSCs possess immunomodulatory properties and can therefore be used to treat diseases. However, the therapeutic effect mechanisms of MSCs are yet to be determined. Here, we investigated these mechanisms using a medication-related osteonecrosis of the jaw (MRONJ)-like mouse model. METHODS: To generate MRONJ-like characteristics, mice received intravenous zoledronate and dexamethasone two times a week. At 1 week after intravenous injection, maxillary first molars were extracted, and at 1 week after tooth extraction, MSCs were isolated from the bone marrow of the mice femurs and tibias. To compare "diseased MSCs" from MRONJ-like mice (d-MSCs) with "control MSCs" from untreated mice (c-MSCs), the isolated MSCs were analyzed by differentiation and colony-forming unit-fibroblast (CFU-F) assays and systemic transplantation of either d-MSCs or c-MSCs into MRONJ-like mice. Furthermore, we observed the exchange of cell contents among d-MSCs and c-MSCs during coculture with all combinations of each MSC type. RESULTS: d-MSCs were inferior to c-MSCs in differentiation and CFU-F assays. Moreover, the d-MSC-treated group did not show earlier healing in MRONJ-like mice. In cocultures with any combination, MSC pairs formed cell-cell contacts and exchanged cell contents. Interestingly, the exchange among c-MSCs and d-MSCs was more frequently observed than other pairs, and d-MSCs were distinguishable from c-MSCs. CONCLUSIONS: The interaction of c-MSCs and d-MSCs, including exchange of cell contents, contributes to the treatment potential of d-MSCs. This cellular behavior might be one therapeutic mechanism used by MSCs for MRONJ.

    DOI: 10.1186/s13287-016-0367-3

  • 口腔インプラントの表面改質の現在と未来 (小特集 医療現場での表面処理)

    鮎川 保則, 熱田 生, 鶴田 勝大, 松下 恭之, 古谷野 潔

    表面技術 = Journal of the Surface Finishing Society of Japan   67 ( 6 )   297 - 301   2016.6

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    DOI: 10.4139/sfj.67.297

  • Soft tissue sealing around dental implants based on histological interpretation. Reviewed

    Atsuta I, Ayukawa Y, Kondo R, Oshiro W, Matsuura Y, Furuhashi A, Tsukiyama Y, Koyano K

    Journal of prosthodontic research   60 ( 1 )   3 - 11   2016.1

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    Soft tissue sealing around dental implants based on histological interpretation.
    PURPOSE: The aim of this study was to provide an overview on the biology and soft tissue sealing around dental implants and teeth. STUDY SELECTION: This is a narrative review performed through scientific articles published between 1977 and 2014, indexed in MEDLINE and PubMed databases. The study selected articles that focused on epithelial sealing around dental implant or teeth with cell biology and histology of soft tissue. RESULTS: Implant therapy has been widely applied in dental rehabilitation for many years, with predictable long-term results. The longevity and functionality of dental implants is dependent on both osseointegration around the implant body and the establishment of a soft tissue barrier that protects the underlying hard tissue structures and the implant itself. The health and stability of the peri-implant mucosa also affects the esthetics of the implant. The healing and maintenance of the epithelial and connective tissues around implants are increasingly recognized as being fundamental to implant success. However, there has been little research into the function or formation of the soft tissue seal around dental implants, and the roles of this unique mucosal interface remain unclear. CONCLUSIONS: This narrative review explores the extent of the current knowledge of soft tissue barriers around implants from both a basic and clinical perspective, and aims to consolidate this knowledge and highlight the most pertinent questions relating to this area of research.

    DOI: 10.1016/j.jpor.2015.07.001

  • 下顎大臼歯欠損に対しインプラント支持固定性補綴装置による治療介入時に付与すべき咬合様式

    近藤 尚知, 尾澤 昌悟, 澤瀬 隆, 横山 敦郎, 関根 秀志, 舞田 健夫, 鮎川 保則, 中野 環, 久保 隆靖, 細川 隆司, 友竹 偉則, 城戸 寛史, 越智 守生, 塩田 真, 尾関 雅彦, 西村 正宏, 前田 芳信, 會田 英紀, 玉置 勝司, 笛木 賢治, 塚崎 弘明, 小野 高裕, 松下 恭之, 松香 芳三, 水口 一, 桑鶴 利香, 山下 秀一郎, 飯塚 知明, 馬場 一美, 藤澤 政紀, 古谷野 潔, 矢谷 博文

    日本補綴歯科学会誌   8 ( 1 )   1 - 9   2016.1

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    インプラント治療が補綴歯科臨床の場で必要不可欠となった今日においても、未だ「インプラント支持固定性補綴装置に付与すべき咬合様式」のガイドラインまたは明確な基準は示されていない。本ポジションペーパーにおいては、その推奨されるべき一定の基準を示し、臨床上の指針として提案することを目的とした。本稿では、典型的な欠損形態である下顎大臼歯部欠損にインプラント支持補綴装置を装着した場合を想定している。口腔インプラントを適用した治療に関して経験豊富なエキスパートパネルを、(公社)日本補綴歯科学会会員から選出し、臨床の現場における事象を検証した結果として得られた意見を集積し、パネル会議で検討した。その結果、補綴装置の形態、咬合接触点の位置と数、側方運動時の咬合接触の有無、歯根膜の変位量の考慮、補綴装置咬合面の材料等に関する知見が得られ、推奨される一定の基準が示された。しかしながら、上記内容は明確な根拠に支持されるものではなく、治療効果と術後経過に関する研究が不十分であり、今後さらなる知見の集積と検証のもとに、ガイドラインを策定すべきである。(著者抄録)

    DOI: 10.2186/ajps.8.1

  • Acceleration of hard and soft tissue healing in the oral cavity by a single transmucosal injection of fluvastatin-impregnated poly (lactic-co-glycolic acid) microspheres. An in vitro and rodent in vivo study. Invited Reviewed International journal

    Noriyuki Yasunami, Yasunori Ayukawa, Akihiro Furuhashi, Ikiru Atsuta, Rakhmatia Yunia D, Yasuko Moriyama, Masuzaki Tomohiro, Kiyoshi Koyano

    Biomedical Materials   11 ( 1 )   015001   2015.12

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  • Additional Effects of Platelet-Rich Fibrin on Bone Regeneration in Sinus Augmentation With Deproteinized Bovine Bone Mineral: Preliminary Results. Reviewed International journal

    Tanaka H, Toyoshima T, Atsuta I, Ayukawa Y, Sasaki M, Matsushita Y, Hiraoka R, Koyano K, Nakamura S

    Implant dentistry   24 ( 6 )   669 - 674   2015.12

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    Additional Effects of Platelet-Rich Fibrin on Bone Regeneration in Sinus Augmentation With Deproteinized Bovine Bone Mineral: Preliminary Results.
    PURPOSE: Platelet-rich fibrin (PRF) has been reported to contribute to bone regeneration; however, little is known about details with deproteinized bovine bone mineral (DBBM). This study aims to evaluate additional effects of PRF on bone regeneration in sinus augmentation with DBBM. MATERIALS AND METHODS: Sinus augmentations were made with DBBM/PRF mixture as lateral approach for 4 sinuses from 4 patients. Bone biopsies were obtained from posterior maxilla at the implant placements 7 or 10 months after sinus augmentations. Histological observations and histomorphometric analyses from augmented areas were performed. RESULTS: The new bone formation was found around the DBBMs with very good contact while surfaces of DBBMs were partly resorbed. Osteoclasts recognized the DBBMs for remodeling, followed by new bone running. The histomorphometric analyses revealed that mean percentages of newly formed bone were 31.7 ± 1.2%, 21.0 ± 1.0%, 38.0 ± 0.6%, and 47.0 ± 0.6%, respectively (mean 34.5 ± 5.7%). CONCLUSIONS: Additional effects of PRF could be found because of higher percentages of newly bone formation by DBBM/PRF mixture than those by DBBM individual in previous reports.

    DOI: 10.1097/ID.0000000000000306

  • Acceleration of hard and soft tissue healing in the oral cavity by a single transmucosal injection of fluvastatin-impregnated poly (lactic-co-glycolic acid) microspheres. An in vitro and rodent in vivo study. Reviewed International journal

    Yasunami N, Ayukawa Y, Furuhashi A, Atsuta I, Rakhmatia YD, Moriyama Y, Masuzaki T, Koyano K

    Biomedical materials (Bristol, England)   11 ( 1 )   15001 - 015001   2015.12

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    Acceleration of hard and soft tissue healing in the oral cavity by a single transmucosal injection of fluvastatin-impregnated poly (lactic-co-glycolic acid) microspheres. An in vitro and rodent in vivo study.
    Antihyperlipidemic drug statins reportedly promote both bone formation and soft tissue healing. We examined the effect of sustained-release, fluvastatin-impregnated poly(lactic-co-glycolic acid) (PLGA) microspheres on the promotion of bone and gingival healing at an extraction socket in vivo, and the effect of fluvastatin on epithelial cells and fibroblasts in vitro. The maxillary right first molar was extracted in rats, then one of the following was immediately injected, as a single dose, into the gingivobuccal fold: control (no administration), PLGA microspheres without a statin (active control), or PLGA microspheres containing 20 or 40 μg kg(-1) of fluvastatin. At days 1, 3, 7, 14, and 28 after injection, bone and soft tissue healing were histologically evaluated. Cell proliferation was measured under the effect of fluvastatin at dosages of 0, 0.01, 0.1, 1.0, 10, and 50 μM. Cell migration and morphology were observed at dosages of 0 and 0.1 μM. Following tooth extraction, the statin significantly enhanced bone volume and density, connective tissue volume, and epithelial wound healing. In the in vitro study, it promoted significant proliferation and migration of epithelial cells and fibroblasts. A single dose of topically administered fluvastatin-impregnated PLGA microspheres promoted bone and soft tissue healing at the extraction site.

    DOI: 10.1088/1748-6041/11/1/015001

  • Additional effects of platelet rich fibrin on bone regeneration in sinus augmentation with deproteinized bovine bone mineral: preliminary results Reviewed International journal

    Hideaki Tanaka, Takeshi Toyoshima, Ikiru Atsuta, Yasunori Ayukawa, Masanori Sasaki, Yasuyuki Matsushita, Ryu Hiraoka, Kiyoshi Koyano, Seiji Nakamura

    Implant Dentistry   24 ( 6 )   669 - 674   2015.12

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  • Primary Stability of a Hybrid Implant Compared with Tapered and Cylindrical Implants in an Ex Vivo Model Reviewed International journal

    Takeshi Toyoshima, Hideaki Tanaka, Yasunori Ayukawa, Miori Howashi, Masuzaki Tomohiro, Takahiro Kiyosue, Kiyoshi Koyano, Seiji Nakamura

    Clinical Implant Dentistry andRelated Research   17 ( 5 )   950 - 956   2015.10

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    DOI: 10.1111/cid.12205

  • Primary Stability of a Hybrid Implant Compared with Tapered and Cylindrical Implants in an Ex Vivo Model. Reviewed International journal

    Toyoshima T, Tanaka H, Ayukawa Y, Howashi M, Masuzaki T, Kiyosue T, Koyano K, Nakamura S

    Clinical implant dentistry and related research   17 ( 5 )   950 - 956   2015.10

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    Primary Stability of a Hybrid Implant Compared with Tapered and Cylindrical Implants in an Ex Vivo Model.
    BACKGROUND: Hybrid implants are thought to offer good stability and bone-implant contact. PURPOSE: This study sought to evaluate the primary stability of a hybrid implant compared with tapered and cylindrical implants in an ex vivo model and compare undersized drilling with standard drilling in attaining primary stability. MATERIALS AND METHODS: Hybrid (Straumann® Bone Level; BL), tapered (Straumann® Tapered Effect; TE), and cylindrical (Straumann® Standard Plus; SP) implants were inserted into 15 mm-thick porcine iliac crest blocks using standard (corticocancellous or cancellous bone) or undersized (cancellous bone only) drilling (n = 7). Stability was evaluated using maximum insertion torque (MIT), implant stability quotient (ISQ), and push-out tests. RESULTS: The mean MIT for BL and TE was significantly higher than that for SP (p < 0.05). With standard drilling in corticocancellous bone, the mean ISQ for TE was significantly higher than that for SP (p < .05). The mean MIT, ISQ, and push-out test scores for BL, TE, and SP with standard drilling in corticocancellous bone were significantly higher than those with undersized or standard drilling in cancellous bone (p < .05). CONCLUSIONS: In this ex vivo model, the hybrid implant demonstrated promising primary stability compared with the cylindrical implant. The improved stability of the hybrid implant was especially evident in cancellous bone. The influence of the cortical layer should be recognized when selecting implants for primary stability.

    DOI: 10.1111/cid.12205

  • Promoting effect of CaCl2 hydrothermal treatment to titanium implant surface for early epithelial sealing. Invited Reviewed International journal

    Wakana Oshiro, Yasunori Ayukawa, Ikiru Atsuta, Akihiro Furuhashi, Junichi Yamazoe, Ryosuke Kondo, Mami Sakaguchi, Yuri Matsuura, Yoshihiro Tsukiyama, Kiyoshi Koyano

    Colloids and Surfaces B: Biointerfaces   131 ( 1 )   141 - 147   2015.10

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  • Histological comparison in rats between carbonate apatite fabricated from gypsum and sintered hydroxyapatite on bone remodeling. Invited Reviewed International journal

    Yasunori Ayukawa, Yumiko Suzuki, Kanji Tsuru, Kiyoshi Koyano, Kunio Ishikawa

    Biomed Research International   579541   2015.7

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  • Fibroblast attachment onto novel titanium mesh membranes for guided bone regeneration Reviewed International journal

    Odontology   103 ( 2 )   218 - 226   2015.5

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    DOI: 10.1007/s10266-014-0151-8

  • Effects of CaCl2 hydrothermal treatment of titanium implant surfaces on early epithelial sealing. Reviewed International journal

    Oshiro W, Ayukawa Y, Atsuta I, Furuhashi A, Yamazoe J, Kondo R, Sakaguchi M, Matsuura Y, Tsukiyama Y, Koyano K

    Colloids and surfaces. B, Biointerfaces   131   141 - 147   2015.4

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    Effects of CaCl2 hydrothermal treatment of titanium implant surfaces on early epithelial sealing.
    Improvement of oral epithelial adhesion to titanium (Ti) may significantly enhance the efficacy of dental implants. We aimed to investigate whether calcium chloride (CaCl2) hydrothermally treated (HT) Ti could promote sealing of the peri-implant epithelium (PIE) around the implant. Right maxillary first molars were extracted from rats and replaced with either CaCl2-HT implants (Ca-HT group), distilled water-HT implants (DW-HT group), or untreated implants (Cont group). After 4 weeks, the implant-PIE interface of the Ca-HT group exhibited a band of immunoreactive laminin-332, similar to the tooth-junctional epithelium interface, which was absent in the Cont and DW-HT groups at the upper portion. We also investigated the effect of Ca-HT on the attachment of rat oral epithelial cells (OECs). OEC adherence onto Ca-HT Ti plates was stronger with higher expression levels of adhesion proteins compared with Cont and DW-HT groups. These results indicate that HT with CaCl2 improves the integration of soft tissue cells with the Ti implant at 4 weeks after implantation, which might facilitate the development of a soft tissue barrier around the implant.

    DOI: 10.1016/j.colsurfb.2015.04.025

  • Additional effects of platelet-rich fibrin on bone regeneration in sinus augmentation with deproteinized bovine bone mineral Preliminary results Reviewed

    Hideaki Tanaka, Takeshi Toyoshima, Atsuta Ikiru, Yasunori Ayukawa, Masanori Sasaki, Yasuyuki Matsushita, Ryu Hiraoka, Kiyoshi Koyano, Seiji Nakamura

    Implant Dentistry   24 ( 6 )   669 - 674   2015.1

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    DOI: 10.1097/ID.0000000000000306

  • Micro-CT and histomorphometric analyses of novel titanium mesh membranes for guided bone regeneration: A study on rat calvarial defects Reviewed International journal

    International Journal of Oral and Maxillofacial Implants   2014.12

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  • Relationship between the CT Value and Cortical Bone Thickness at Implant Recipient Sites and Primary Implant Stability with Comparison of Different Implant Types Reviewed International journal

    Miori Howashi, Yoshihiro Tsukiyama, Yasunori Ayukawa, Kei Isoda-Akizuki, Masafumi Kihara, Yu Imai, Motofumi Sogo, Kiyoshi Koyano

    Clinical Implant Dentistry andRelated Research   18 ( 1 )   107 - 116   2014.11

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  • Prosthetic aspects in adult osteoporosis Reviewed International journal

    Yoichiro Ogino, Yasunori Ayukawa, Yoko TOMITA, Kiyoshi Koyano

    Journal of Prosthetic Dentistry   2014.10

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  • PROSTHETIC ASPECTS IN ADULT OSTEOPETROSIS Reviewed International journal

    Yoichiro Ogino, Yasunori Ayukawa, Yoko Tomita, Kiyoshi Koyano

    JOURNAL OF PROSTHETIC DENTISTRY   112 ( 4 )   736 - 740   2014.10

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    DOI: 10.1016/j.prosdent.2014.04.007

  • In vivo and in vitro studies of epithelial cell behavior around titanium implants with machined and rough surface Reviewed International journal

    Ikiru Atsuta, Yasunori Ayukawa, Akihiro Furuhashi, Yoichiro Ogino, Moriyama Yasuko, Yoshihiro Tsukiyama, Kiyoshi Koyano

    Clinical Implant Dentistry andRelated Research   16 ( 5 )   772 - 781   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cid.12043

  • Relationship between the CT Value and Cortical Bone Thickness at Implant Recipient Sites and Primary Implant Stability with Comparison of Different Implant Types. Reviewed International journal

    Howashi M, Tsukiyama Y, Ayukawa Y, Isoda-Akizuki K, Kihara M, Imai Y, Sogo M, Koyano K

    Clinical implant dentistry and related research   18 ( 1 )   107 - 16   2014.9

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    Relationship between the CT Value and Cortical Bone Thickness at Implant Recipient Sites and Primary Implant Stability with Comparison of Different Implant Types.
    BACKGROUND: Studies have shown that bone quality at the implant recipient site can influence primary stability. PURPOSE: The aims of this study were to explore the quantitative estimation of the primary stability of implants preoperatively using CT values and to examine the effect of different implant designs with recommended socket preparation on primary stability. MATERIALS AND METHODS: Forty-four fresh porcine femoral heads were prepared. The bone surrounding implant sockets was preoperatively evaluated by helical CT. Forty-four implants (φ 4.3 × 10 mm), 22 straight and 22 tapered, were placed according to the manufacturer's instructions. The insertion torque value (ITV), implant stability quotient (ISQ), and removal torque value (RTV) were recorded as indicators of primary implant stability. RESULTS: Significant correlations and linear relationships were found between the CT value and ITV, ISQ, and RTV for both straight and tapered implants (Spearman's correlation coefficient, p < .001; linear regression analysis, p < .01). Tapered implants had a significantly higher ITV than straight implants (analysis of covariance, p < .01). CONCLUSIONS: Obtained results suggest that the primary stability of implants could be quantitatively estimated using the CT value preoperatively, indicating the CT value of bone surrounding an implant can contribute considerably to implant planning and design choice in clinical situations.

    DOI: 10.1111/cid.12261

  • Microcomputed Tomographic and Histomorphometric Analyses of Novel Titanium Mesh Membranes for Guided Bone Regeneration: A Study in Rat Calvarial Defects Reviewed

    Yunia Dwi Rakhmatia, Yasunori Ayukawa, Akihiro Furuhashi, Kiyoshi Koyano

    INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS   29 ( 4 )   826 - 835   2014.7

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    DOI: 10.11607/jomi.3219

  • Implant treatment followed by living donor lung transplant: A follow-up case report Reviewed International journal

    Akinari Nakagawa, Naoki Shitara, Yasunori AYUKAWA, Kiyoshi Koyano, Kenji Nishimura

    Journal of Prosthodontic Research   58 ( 2 )   127 - 131   2014.4

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    DOI: http://dx.doi.org/10.1016/j.jpor.2013.11.001

  • Implant treatment followed by living donor lung transplant: A follow-up case report Reviewed

    Akinari Nakagawa, Naoki Shitara, Yasunori Ayukawa, Kiyoshi Koyano, Kenji Nishimura

    JOURNAL OF PROSTHODONTIC RESEARCH   58 ( 2 )   127 - 131   2014.4

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    DOI: 10.1016/j.jpor.2013.11.001

  • Mesenchymal Stem Cells Markedly Suppress Inflammatory Bone Destruction in Rats with Adjuvant-Induced Arthritis Reviewed International journal

    Toshio Takano, Yin-Ji Li, Akiko Kukita, Takayoshi Yamaza, Yasunori Ayukawa, Kanako Moriyama, Norihisa Uehara, Hisayuki Nomiyama, Kiyoshi Koyano, Toshio Kukita

    Laboratory Investigation   94   286 - 296   2014.3

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  • Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis Reviewed International journal

    Toshio Takano, Yin-Ji Li, Akiko Kukita, Takayoshi Yamaza, Yasunori Ayukawa, Kanako Moriyama, Norihisa Uehara, Hisayuki Nomiyama, Kiyoshi Koyano, Toshio Kukita

    LABORATORY INVESTIGATION   94 ( 3 )   286 - 296   2014.3

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    DOI: 10.1038/labinvest.2013.152

  • Fibroblast attachment onto novel titanium mesh membranes for guided bone regeneration. Reviewed

    Rakhmatia YD, Ayukawa Y, Atsuta I, Furuhashi A, Koyano K

    Odontology / the Society of the Nippon Dental University   103 ( 2 )   218 - 226   2014.3

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    Fibroblast attachment onto novel titanium mesh membranes for guided bone regeneration.
    Titanium mesh is used in orthopedic surgery as a barrier membrane, as it offers suitable characteristics, which allow mechanical support during the formation of new bone. An ideal membrane would facilitate cell attachment onto its surface, thereby helping to stabilize the blood clot and integrate the membrane into the tissue. However, currently available titanium mesh has millimeter-level pore sizes, which lead to soft tissue ingrowth through the pores. Therefore, the aim of this study was to investigate the fibroblast attachment and migration on different designs of novel titanium mesh with micrometer pore size for guided bone regeneration treatment. Six types of novel titanium mesh membrane and three groups of commercially available membranes were used in this study. Fibroblasts were isolated from 4-day-old green fluorescence protein rats and seeded onto membrane surfaces. At 24 h, the cells attached to the membrane surfaces were fixed and stained with DAPI. The blue-stained nuclei on membrane surfaces, and both upper and lower sides were counted. It was shown that different membrane materials, structure and design differ considerably in their capacity for cell attachment to the membrane surface. The novel membranes, especially mesh with 12 pores compared with mesh with multi-pores, allowed the fibroblast attachment on the membrane surface, but hindered the fibroblast migration through the pores into the lower side of the membrane, which is associated with the defect area in the clinical condition.

    DOI: 10.1007/s10266-014-0151-8

  • Therapeutic Interaction of Systemically-administered Mesenchymal Stem Cells with Peri-implant Mucosa Reviewed International journal

    Ryosuke Kondo, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Yuri Matsuura, Akihiro Furuhashi, Yoshihiro Tsukiyama, Kiyoshi Koyano

    PLoS One   9 ( 3 )   e90681   2014.3

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    DOI: 10.1371/journal.pone.0090681

  • Bacterial adhesion affinities of various implant abutment materials Reviewed International journal

    Koichi Yamane, Yasunori Ayukawa, Toru Takeshita, Akihiro Furuhashi, Yoshihisa Yamashita, Kiyoshi Koyano

    Clinical Oral Implants Research   24   1310 - 1315   2013.12

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  • Bacterial adhesion affinities of various implant abutment materials International journal

    Koichi Yamane, Yasunori Ayukawa, Toru Takeshita, Akihiro Furuhashi, Yoshihisa Yamashita, Kiyoshi Koyano

    Clinical Oral Implants Research   24 ( 12 )   1310 - 1315   2013.12

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    Bacterial adhesion affinities of various implant abutment materials
    Objectives: To investigate bacterial adhesion to various abutment materials. Material and methods: Thirty volunteers participated in this study. Resin splints were fabricated, and five types of disks were fabricated from pure titanium, gold-platinum alloy, zirconia, alumina, and hydroxyapatite with uniform surface roughness and attached to the buccal surface of each splint. After 4 days of use by the subjects, the plaque accumulated on the disk surfaces was analyzed. The bacterial community structure was evaluated using 16S rRNA gene profiling with terminal restriction fragment length polymorphism analysis. The total bacterial count on each disk was estimated using quantitative polymerase chain reaction. Results: Terminal restriction fragment length polymorphism profiles were more similar between tested materials than between subjects, suggesting that the bacterial community structures on the abutment material were influenced more by the individuals than by the type of material. However, the total number of bacteria attached to a disk was significantly different among five materials (P < 0.001, Brunner-Langer test for longitudinal data). Fewer bacteria were attached to the gold-platinum alloy than to the other materials. Conclusions: Gold-platinum alloy appears to be useful material for abutments when considering the accumulation of plaque. However, alternative properties of the abutment material, such as effects on soft tissue healing, should also be taken into consideration when choosing an abutment material. © 2012 John Wiley & Sons A/S.

    DOI: 10.1111/j.1600-0501.2012.02574.x

  • The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium Reviewed International journal

    Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Akihiro Furuhashi, Kiyoshi Koyano

    Archives of Oral Biology   2013.11

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  • The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium. Reviewed International journal

    Atsuta I, Ayukawa Y, Yamaza T, Furuhashi A, Koyano K

    Archives of oral biology   58 ( 11 )   1696 - 1708   2013.11

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    The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium.
    BACKGROUND: Oral epithelial cells (OECs) adhesion to titanium may improve the success rate of implant restoration. PURPOSE: We investigated the mechanism by which OECs adhere to titanium dental implants. MATERIALS AND METHODS: (1) After culturing rat OECs on titanium plates (Ti) or culture dishes in the presence or absence of a phosphoinositide 3-kinase (PI3K) activator or inhibitors and/or growth factors, and OEC morphology under these conditions were analyzed. (2) Right maxillary first molars were extracted and replaced with experimental implants. The rats were treated with or without growth factors. RESULTS: (1) Cell adherence was lower of OECs on Ti than in those on culture dishes, as were the levels of integrin β4 and the continuity of F-actin structures. After PI3K inhibition, markedly reducing adherence to both substrates. In contrast, PI3K activation with activator or insulin-like growth factor restored the OEC adherence and the expression of adhesion molecules on Ti to the levels seen in OECs cultured on dishes. Cell migration was inhibited by PI3K activation. (2) High expression of integrin β4 was observed in the peri-implant epithelia of PI3K-activated rats. CONCLUSION: These findings suggest that PI3K plays an important role in the adhesion of OECs to Ti.

    DOI: 10.1016/j.archoralbio.2013.07.013

  • The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium. Reviewed International journal

    Atsuta I, Ayukawa Y, Yamaza T, Furuhashi A, Koyano K

    Archives of oral biology   58 ( 11 )   1696 - 1708   2013.11

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    The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium.
    BACKGROUND: Oral epithelial cells (OECs) adhesion to titanium may improve the success rate of implant restoration. PURPOSE: We investigated the mechanism by which OECs adhere to titanium dental implants. MATERIALS AND METHODS: (1) After culturing rat OECs on titanium plates (Ti) or culture dishes in the presence or absence of a phosphoinositide 3-kinase (PI3K) activator or inhibitors and/or growth factors, and OEC morphology under these conditions were analyzed. (2) Right maxillary first molars were extracted and replaced with experimental implants. The rats were treated with or without growth factors. RESULTS: (1) Cell adherence was lower of OECs on Ti than in those on culture dishes, as were the levels of integrin β4 and the continuity of F-actin structures. After PI3K inhibition, markedly reducing adherence to both substrates. In contrast, PI3K activation with activator or insulin-like growth factor restored the OEC adherence and the expression of adhesion molecules on Ti to the levels seen in OECs cultured on dishes. Cell migration was inhibited by PI3K activation. (2) High expression of integrin β4 was observed in the peri-implant epithelia of PI3K-activated rats. CONCLUSION: These findings suggest that PI3K plays an important role in the adhesion of OECs to Ti.

    DOI: 10.1016/j.archoralbio.2013.07.013

  • Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants Reviewed International journal

    Ikiru Atsuta, Yasunori Ayukawa, Akihiro Furuhashi, Takayoshi Yamaza, Hideyuki Okwachi, Kiyoshi Koyano

    Journal of Biomedical MAterials Research A   101   2896 - 2904   2013.10

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  • Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants Reviewed International journal

    ATSUTA IKIRU, AYUKAWA Yasunori, Furuhashi Akihiko, Yamaza Takayoshi, TSUKIYAMA Yoshihiro, KOYANO Kiyoshi

    J Biomed Mater Res A   101 ( 10 )   2896 - 2904   2013.10

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    Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants
    Improvement of oral epithelial adhesion to titanium (Ti) may significantly enhance the efficacy of dental implants. Here, we investigated whether insulin-like growth factor-1 (IGF-1) improved the sealing of the peri-implant epithelium (PIE) around the implant. Right maxillary first molars were extracted from rats and replaced with experimental implants. After 4 weeks of IGF-1 treatment, the implant-PIE interface exhibited a band of immunoreactive laminin-332 (Ln-5), similar to the tooth-junctional epithelium interface, that was partially absent in the untreated group. Immunoelectron microscopy showed a characteristic Ln-5-positive band including hemidesmosomes at both the apical and upper portions of the implant-PIE interface in the IGF-1-treated group. We also investigated the effects of IGF-1/PI3K inhibitors on the dynamics of rat oral epithelial cells (OECs) grown on Ti plates. In OECs cultured with IGF-1, adhesion protein expression increased, cell adherence to Ti plates was higher, and proliferation was faster, whereas migration and apoptosis were induced in the absence of IGF-1 or in the presence of both IGF-1 and a PI3K inhibitor. These data suggest that PI3K mediates the promotive effects of IGF-1, and that IGF-1 is effective at enhancing epithelial integration around Ti implants.

    DOI: 10.1002/jbm.a.34608

  • Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants Reviewed International journal

    ATSUTA IKIRU, AYUKAWA Yasunori, Furuhashi Akihiko, Yamaza Takayoshi, TSUKIYAMA Yoshihiro, KOYANO Kiyoshi

    J Biomed Mater Res A   101 ( 10 )   2896 - 2904   2013.10

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    Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants
    Improvement of oral epithelial adhesion to titanium (Ti) may significantly enhance the efficacy of dental implants. Here, we investigated whether insulin-like growth factor-1 (IGF-1) improved the sealing of the peri-implant epithelium (PIE) around the implant. Right maxillary first molars were extracted from rats and replaced with experimental implants. After 4 weeks of IGF-1 treatment, the implant-PIE interface exhibited a band of immunoreactive laminin-332 (Ln-5), similar to the tooth-junctional epithelium interface, that was partially absent in the untreated group. Immunoelectron microscopy showed a characteristic Ln-5-positive band including hemidesmosomes at both the apical and upper portions of the implant-PIE interface in the IGF-1-treated group. We also investigated the effects of IGF-1/PI3K inhibitors on the dynamics of rat oral epithelial cells (OECs) grown on Ti plates. In OECs cultured with IGF-1, adhesion protein expression increased, cell adherence to Ti plates was higher, and proliferation was faster, whereas migration and apoptosis were induced in the absence of IGF-1 or in the presence of both IGF-1 and a PI3K inhibitor. These data suggest that PI3K mediates the promotive effects of IGF-1, and that IGF-1 is effective at enhancing epithelial integration around Ti implants.

    DOI: 10.1002/jbm.a.34608

  • Bone regeneration of tibial defects in rats with enzymatic hydrogelation of gelatin derivative and recombinant human platelet-derived growth factor-BB complex. Reviewed

    Kondo D, Ogino Y, Ayukawa Y, Sakai S, Kawakami K, Koyano K

    The International journal of oral & maxillofacial implants   28 ( 5 )   1377 - 1385   2013.9

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    Bone regeneration of tibial defects in rats with enzymatic hydrogelation of gelatin derivative and recombinant human platelet-derived growth factor-BB complex.

    DOI: 10.11607/jomi.2861

  • Bone regeneration of rat tibia defects with enzymatically hydrogelation of gelatin derivative and recombinant human platelet-derived growth factor-BB complex Reviewed International journal

    Daisuke Kondo, YOICHIRO OGINO, Yasunori AYUKAWA, Shinji Sakai, KOEI KAWAKAMI, kiyoshi koyano

    Int J Oral Maxillofac Implants   2013.8

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  • Tunneling Nanotube Formation is Essential for the Regulation of Osteoclastogenesis Reviewed International journal

    Akira Takahashi, Akiko Kukita, Li YinJi, Jing-qi Zhang, Hisayuki Nomiyama, Takayoshi Yamaza, Yasunori AYUKAWA, kiyoshi koyano, Toshio Kukita

    J Cellular Biochem   114 ( 6 )   1238 - 1247   2013.6

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  • Tunneling nanotube formation is essential for the regulation of osteoclastogenesis. Reviewed International journal

    Takahashi A, Kukita A, Li YJ, Zhang JQ, Nomiyama H, Yamaza T, Ayukawa Y, Koyano K, Kukita T

    Journal of cellular biochemistry   114 ( 6 )   1238 - 1247   2013.6

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    Tunneling nanotube formation is essential for the regulation of osteoclastogenesis.
    Osteoclasts are the multinucleated giant cells formed by cell fusion of mononuclear osteoclast precursors. Despite the finding of several membrane proteins involving DC-STAMP as regulatory proteins required for fusion among osteoclast precursors, cellular and molecular events concerning this process are still ambiguous. Here we identified Tunneling Nanotubes (TNTs), long intercellular bridges with small diameters, as the essential cellular structure for intercellular communication among osteoclast precursors in prior to cell fusion. Formation of TNTs was highly associated with osteoclastogenesis and it was accompanied with the significant induction of the M-Sec gene, an essential gene for TNT formation. M-Sec gene expression was significantly upregulated by RANKL-treatment in osteoclast precursor cell line. Blockage of TNT formation by Latrunclin B or by M-Sec siRNA significantly suppressed osteoclastogenesis. We have detected the rapid intercellular transport of not only the membrane phospholipids labeled with DiI but also the DC-STAMP-GFP fusion protein through TNTs formed among osteoclast precursors during osteoclastogenesis. Transportation of such regulatory molecules through TNTs would be essential for the process of the specific cell fusion among osteoclast precursors.

    DOI: 10.1002/jcb.24433

  • Tunneling nanotube formation is essential for the regulation of osteoclastogenesis. Reviewed International journal

    Takahashi A, Kukita A, Li YJ, Zhang JQ, Nomiyama H, Yamaza T, Ayukawa Y, Koyano K, Kukita T

    Journal of cellular biochemistry   114 ( 6 )   1238 - 1247   2013.6

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    Tunneling nanotube formation is essential for the regulation of osteoclastogenesis.
    Osteoclasts are the multinucleated giant cells formed by cell fusion of mononuclear osteoclast precursors. Despite the finding of several membrane proteins involving DC-STAMP as regulatory proteins required for fusion among osteoclast precursors, cellular and molecular events concerning this process are still ambiguous. Here we identified Tunneling Nanotubes (TNTs), long intercellular bridges with small diameters, as the essential cellular structure for intercellular communication among osteoclast precursors in prior to cell fusion. Formation of TNTs was highly associated with osteoclastogenesis and it was accompanied with the significant induction of the M-Sec gene, an essential gene for TNT formation. M-Sec gene expression was significantly upregulated by RANKL-treatment in osteoclast precursor cell line. Blockage of TNT formation by Latrunclin B or by M-Sec siRNA significantly suppressed osteoclastogenesis. We have detected the rapid intercellular transport of not only the membrane phospholipids labeled with DiI but also the DC-STAMP-GFP fusion protein through TNTs formed among osteoclast precursors during osteoclastogenesis. Transportation of such regulatory molecules through TNTs would be essential for the process of the specific cell fusion among osteoclast precursors.

    DOI: 10.1002/jcb.24433

  • Influence of titanium surface topography on peri-implant soft tissue integration Reviewed International journal

    Key Engineering Materials   529-530   559 - 564   2013.4

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  • Expression of Integrin alpha-3 and beta-4 subunits on the process of peri-implant epithelium formation Reviewed International journal

    ATSUTA IKIRU, Yasunori AYUKAWA, Takayoshi Yamaza, Akihiro Furuhashi, Ryosuke Kondo, kiyoshi koyano

    Key Engineering Materials   529-530   407 - 412   2013.4

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  • In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces Reviewed International journal

    ATSUTA IKIRU, AYUKAWA Yasunori, Furuhashi Akihiko, OGINO YOICHIRO, Moriyama Yasuko, Tsukiyama Yoshihiro, Koyano Kiyoshi

    Clin Implant Dent Relat Res   16 ( 5 )   772 - 81   2013.2

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    In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces
    BACKGROUND: The surface roughness of a dental implant affects the epithelial wound healing process and may significantly enhance implant prognosis. PURPOSE: We explored the influence of surface roughness on peri-implant epithelium (PIE) sealing and down-growth by comparing machine-surfaced (Ms) and rough-surfaced (Rs) implants. MATERIALS AND METHODS: (1) Maxillary first molars were extracted from rats and replaced with Ms or Rs implants. (2) We also compared changes in the morphology of cultured rat oral epithelial cells (OECs) grown on Ms or Rs titanium (Ti) plates. RESULTS: (1) After 4 weeks, the PIE around Ms and Rs implants showed a similar structure to junctional epithelium (JE). At 16 weeks, Rs implants appeared to form a weak epithelial seal at the tissue-implant interface and exhibited markedly less PIE down-growth than Ms implants but was deeper than that observed in natural teeth. (2) We observed less expression of adhesion proteins in OECs cultured on Rs plates than in cells grown on Ms plates. Additionally, cell adherence, migration, and proliferation on Rs plates were lower, whereas apoptosis was reduced on Ms plates. CONCLUSION: Ms implants are a better choice for integration with an epithelial wound healing process.

    DOI: 10.1111/cid.12043

  • In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces Reviewed International journal

    ATSUTA IKIRU, AYUKAWA Yasunori, Furuhashi Akihiko, OGINO YOICHIRO, Moriyama Yasuko, Tsukiyama Yoshihiro, Koyano Kiyoshi

    Clin Implant Dent Relat Res   16 ( 5 )   772 - 81   2013.2

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    In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces
    BACKGROUND: The surface roughness of a dental implant affects the epithelial wound healing process and may significantly enhance implant prognosis. PURPOSE: We explored the influence of surface roughness on peri-implant epithelium (PIE) sealing and down-growth by comparing machine-surfaced (Ms) and rough-surfaced (Rs) implants. MATERIALS AND METHODS: (1) Maxillary first molars were extracted from rats and replaced with Ms or Rs implants. (2) We also compared changes in the morphology of cultured rat oral epithelial cells (OECs) grown on Ms or Rs titanium (Ti) plates. RESULTS: (1) After 4 weeks, the PIE around Ms and Rs implants showed a similar structure to junctional epithelium (JE). At 16 weeks, Rs implants appeared to form a weak epithelial seal at the tissue-implant interface and exhibited markedly less PIE down-growth than Ms implants but was deeper than that observed in natural teeth. (2) We observed less expression of adhesion proteins in OECs cultured on Rs plates than in cells grown on Ms plates. Additionally, cell adherence, migration, and proliferation on Rs plates were lower, whereas apoptosis was reduced on Ms plates. CONCLUSION: Ms implants are a better choice for integration with an epithelial wound healing process.

    DOI: 10.1111/cid.12043

  • Current barrier membranes: titanium mesh and other membranes for guided bone regeneration in dental applications. Reviewed

    Rakhmatia YD, Ayukawa Y, Furuhashi A, Koyano K

    Journal of prosthodontic research   57 ( 1 )   3 - 14   2013.1

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    Current barrier membranes: titanium mesh and other membranes for guided bone regeneration in dental applications.
    Research on guided bone regeneration (GBR) is still ongoing, with evidence mainly from preclinical studies. Various current barrier membranes should fulfill the main design criteria for GBR, such as biocompatibility, occlusivity, spaciousness, clinical manageability and the appropriate integration with the surrounding tissue. These GBR characteristics are required to provide the maximum membrane function and mechanical support to the tissue during bone formation. In this review, various commercially available, resorbable and non-resorbable membranes with different characteristics are discussed and summarized for their usefulness in preclinical studies. Membranes offer promising solutions in animal models; however, an ideal membrane has not been established yet for clinical applications. Every membrane type presents both advantages and disadvantages. Titanium mesh membranes offer superb mechanical properties for GBR treatment and its current efficacy in trials will be a focus in this review. A thorough understanding of the benefits and limitations inherent to various materials in specific clinical applications will be of great value and aid in the selection of an optimal membrane for GBR.

    DOI: 10.1016/j.jpor.2012.12.001

  • Effect of titanium surface calcium and magnesium on adhesive activity of epithelial-like cells and fibroblasts. Reviewed International journal

    Okawachi H, Ayukawa Y, Atsuta I, Furuhashi A, Sakaguchi M, Yamane K, Koyano K

    Biointerphases   7 ( 1-4 )   27 - 27   2012.12

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    Effect of titanium surface calcium and magnesium on adhesive activity of epithelial-like cells and fibroblasts.
    In the present study, we investigated the hydrothermal treatment of titanium with divalent cation solutions and its effect in promoting the adhesion of gingival epithelial cells and fibroblasts in vitro. Gingival keratinocyte-like Sa3 cells or fibroblastic NIH3T3 cells were cultured for 1 h on experimental titanium plates hydrothermally-treated with CaCl(2) (Ca) or MgCl(2) (Mg) solution, or distilled water (DW). The number and adhesive strengths of attached cells on the substrata were then analyzed. The number of Sa3 cells adhering to the Ca- and Mg-treated plates was significantly larger than in the DW group, but the strength of this adhesion did not differ significantly between groups. In contrast, NIH3T3 cell adhesion number and strength were increased in both the Ca and Mg groups compared to the DW group. Fluorescent microscopic observation indicated that, in all groups, Sa3 had identical expression levels of integrin β4 and development of actin filaments, whereas NIH3T3 cells in the Ca and Mg groups displayed much stronger punctate cytoplasmic signals for vinculin and more bundle-shaped actin filaments than cells in the DW group. As a result, it was indicated that the hydrothermal treatment of titanium with Ca or Mg solution improved the integration of soft tissue cells with the substrata, which may facilitate the development of a soft tissue barrier around the implant.

    DOI: 10.1007/s13758-012-0027-9

  • Effect of titanium surface calcium and magnesium on adhesive activity of epithelial-like cells and fibroblasts. Reviewed International journal

    Okawachi H, Ayukawa Y, Atsuta I, Furuhashi A, Sakaguchi M, Yamane K, Koyano K

    Biointerphases   7 ( 1-4 )   27 - 27   2012.12

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    Effect of titanium surface calcium and magnesium on adhesive activity of epithelial-like cells and fibroblasts.
    In the present study, we investigated the hydrothermal treatment of titanium with divalent cation solutions and its effect in promoting the adhesion of gingival epithelial cells and fibroblasts in vitro. Gingival keratinocyte-like Sa3 cells or fibroblastic NIH3T3 cells were cultured for 1 h on experimental titanium plates hydrothermally-treated with CaCl(2) (Ca) or MgCl(2) (Mg) solution, or distilled water (DW). The number and adhesive strengths of attached cells on the substrata were then analyzed. The number of Sa3 cells adhering to the Ca- and Mg-treated plates was significantly larger than in the DW group, but the strength of this adhesion did not differ significantly between groups. In contrast, NIH3T3 cell adhesion number and strength were increased in both the Ca and Mg groups compared to the DW group. Fluorescent microscopic observation indicated that, in all groups, Sa3 had identical expression levels of integrin β4 and development of actin filaments, whereas NIH3T3 cells in the Ca and Mg groups displayed much stronger punctate cytoplasmic signals for vinculin and more bundle-shaped actin filaments than cells in the DW group. As a result, it was indicated that the hydrothermal treatment of titanium with Ca or Mg solution improved the integration of soft tissue cells with the substrata, which may facilitate the development of a soft tissue barrier around the implant.

    DOI: 10.1007/s13758-012-0027-9

  • Relationship between magnitude of immediate loading and peri-implant osteogenesis in dogs Reviewed International journal

    Daisuke Esaki, Yasuyuki Matsushita, Yasunori Ayukawa, Nobuo Sakai, Yoshinori Sawae, Kiyoshi Koyano

    CLINICAL ORAL IMPLANTS RESEARCH   23 ( 11 )   1290 - 1296   2012.11

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    DOI: 10.1111/j.1600-0501.2011.02305.x

  • Relationship between magnitude of immediate loading and peri-implant osteogenesis in dogs Reviewed International journal

    Daisuke Esaki, Yasuyuki Matsushita, Yasunori Ayukawa, Nobuo Sakai, Yoshinori Sawae, Kiyoshi Koyano

    CLINICAL ORAL IMPLANTS RESEARCH   23 ( 11 )   1290 - 1296   2012.11

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    DOI: 10.1111/j.1600-0501.2011.02305.x

  • Relationship between the bone density estimated by cone-beam computed tomography and the primary stability of dental implants. Reviewed International journal

    Isoda K, Ayukawa Y, Tsukiyama Y, Sogo M, Matsushita Y, Koyano K

    Clin Oral Implants Res   23 ( 7 )   832 - 826   2012.7

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    Relationship between the bone density estimated by cone-beam computed tomography and the primary stability of dental implants.
    OBJECTIVES: The aims of this study were to objectively assess bone quality with density values obtained by cone-beam computed tomography (CBCT) and to determine the correlations between bone density and primary stability of dental implants. MATERIAL AND METHODS: Eighteen Straumann implants were inserted into 18 fresh femoral heads of swine. The bone densities of implant recipient sites were preoperatively determined by the density value using CBCT. The maximum insertion torque value of each implant was recorded using a digital torque meter. Resonance frequency, which represented a quantitative unit called the implant stability quotient (ISQ), was measured using an Osstell Mentor immediately after the implant placement. Spearman's correlation coefficient was calculated to evaluate the correlations among density values, insertion torques, and ISQs at implant placement. RESULTS: The density values ranged from 98 to 902. The mean density value, insertion torque, and ISQ were 591 ± 226, 13.4 ± 5.2 Ncm, and 67.1 ± 8.1, respectively. Statistically significant correlations were found between the density values and insertion torque (r(s) =0.796, P<0.001), density values and ISQ (r(s) =0.529, P=0.024), and insertion torque and ISQ (r(s) =0.758, P<0.001). CONCLUSIONS: The bone quality evaluated by specific CBCT showed a high correlation with the primary stability of the implants. Hence, preoperative density value estimations by CBCT may allow clinicians to predict implant stability. Whether the density values obtained by the CBCT device used in the present study could be applied to other devices requires further elucidation.

    DOI: 10.1111/j.1600-0501.2011.02203.x

  • The difference of fibroblast behavior on titanium substrata with different surface characteristics. Reviewed

    Furuhashi A, Ayukawa Y, Atsuta I, Okawachi H, Koyano K

    Odontology / the Society of the Nippon Dental University   100 ( 2 )   199 - 205   2012.7

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    The difference of fibroblast behavior on titanium substrata with different surface characteristics.
    Connective tissue, one of the main components of peri-implant soft tissue, is key to the formation of the peri-implant mucosal seal and helping to prevent epithelial ingrowth. Rough surfaces (Rs), machined surfaces (Ms) or microgrooved surface (MG) are used in the neck area of commercially available titanium implants. In this paper, we aimed to evaluate the influence of surface topography of titanium substratum on connective tissue fibroblasts to gain a better understanding of this effect. Fibroblasts were cultured on titanium plates with Rs, Ms and MG. Adhesion cell number at day 3 was compared and protein distribution of both F-actin and vinculin was determined to observe cellular structure and adhesion. Cell adhesion strength was compared on each surface. At day 3, the number of fibroblasts attached on each substratum was in the order of MG ≈ Ms > Rs. Fibroblasts strongly expressed vinculin in the peripheral area on Ms and MG, and showed strong F-actin architecture. Decreased expression of vinculin and weaker continuity of F-actin were observed on Rs. Fibroblasts on MG were aligned along the grooves, with a significantly higher cell density, whereas cells on Ms and Rs had no clear orientation. The cell adhesion strength was significantly lower on Rs, and no significant difference was seen between MG and Ms. Both MG and Ms showed greater adhesion cell numbers and adhesion strength of fibroblasts when compared with Rs at day 3. The cell density on MG was greater than those on other substrata.

    DOI: 10.1007/s10266-011-0029-y

  • Relationship between the bone density estimated by cone-beam computed tomography and the primary stability of dental implants. Reviewed International journal

    Isoda K, Ayukawa Y, Tsukiyama Y, Sogo M, Matsushita Y, Koyano K

    Clin Oral Implants Res   23 ( 7 )   832 - 826   2012.7

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    Relationship between the bone density estimated by cone-beam computed tomography and the primary stability of dental implants.
    OBJECTIVES: The aims of this study were to objectively assess bone quality with density values obtained by cone-beam computed tomography (CBCT) and to determine the correlations between bone density and primary stability of dental implants. MATERIAL AND METHODS: Eighteen Straumann implants were inserted into 18 fresh femoral heads of swine. The bone densities of implant recipient sites were preoperatively determined by the density value using CBCT. The maximum insertion torque value of each implant was recorded using a digital torque meter. Resonance frequency, which represented a quantitative unit called the implant stability quotient (ISQ), was measured using an Osstell Mentor immediately after the implant placement. Spearman's correlation coefficient was calculated to evaluate the correlations among density values, insertion torques, and ISQs at implant placement. RESULTS: The density values ranged from 98 to 902. The mean density value, insertion torque, and ISQ were 591 ± 226, 13.4 ± 5.2 Ncm, and 67.1 ± 8.1, respectively. Statistically significant correlations were found between the density values and insertion torque (r(s) =0.796, P<0.001), density values and ISQ (r(s) =0.529, P=0.024), and insertion torque and ISQ (r(s) =0.758, P<0.001). CONCLUSIONS: The bone quality evaluated by specific CBCT showed a high correlation with the primary stability of the implants. Hence, preoperative density value estimations by CBCT may allow clinicians to predict implant stability. Whether the density values obtained by the CBCT device used in the present study could be applied to other devices requires further elucidation.

    DOI: 10.1111/j.1600-0501.2011.02203.x

  • The difference of fibroblast behavior on titanium substrata with different surface characteristics. Reviewed

    Furuhashi A, Ayukawa Y, Atsuta I, Okawachi H, Koyano K

    Odontology / the Society of the Nippon Dental University   100 ( 2 )   199 - 205   2012.7

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    The difference of fibroblast behavior on titanium substrata with different surface characteristics.
    Connective tissue, one of the main components of peri-implant soft tissue, is key to the formation of the peri-implant mucosal seal and helping to prevent epithelial ingrowth. Rough surfaces (Rs), machined surfaces (Ms) or microgrooved surface (MG) are used in the neck area of commercially available titanium implants. In this paper, we aimed to evaluate the influence of surface topography of titanium substratum on connective tissue fibroblasts to gain a better understanding of this effect. Fibroblasts were cultured on titanium plates with Rs, Ms and MG. Adhesion cell number at day 3 was compared and protein distribution of both F-actin and vinculin was determined to observe cellular structure and adhesion. Cell adhesion strength was compared on each surface. At day 3, the number of fibroblasts attached on each substratum was in the order of MG ≈ Ms > Rs. Fibroblasts strongly expressed vinculin in the peripheral area on Ms and MG, and showed strong F-actin architecture. Decreased expression of vinculin and weaker continuity of F-actin were observed on Rs. Fibroblasts on MG were aligned along the grooves, with a significantly higher cell density, whereas cells on Ms and Rs had no clear orientation. The cell adhesion strength was significantly lower on Rs, and no significant difference was seen between MG and Ms. Both MG and Ms showed greater adhesion cell numbers and adhesion strength of fibroblasts when compared with Rs at day 3. The cell density on MG was greater than those on other substrata.

    DOI: 10.1007/s10266-011-0029-y

  • Evaluations of epithelial sealing and peri-implant epithelial down-growth around "step-type" implants. Reviewed International journal

    Atsuta I, Ayukawa Y, Ogino Y, Moriyama Y, Jinno Y, Koyano K

    Clinical oral implants research   23 ( 4 )   459 - 466   2012.4

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    Evaluations of epithelial sealing and peri-implant epithelial down-growth around "step-type" implants.
    OBJECTIVE: Implant designs that can stimulate and integrate with an epithelial wound-healing process may significantly enhance the efficacy of dental implants. Here, we evaluated the potential of "step-type" implant systems to improve the sealing between the peri-implant epithelium (PIE) and the implant surface, and investigated the effect of implant structure on PIE down-growth. MATERIALS AND METHODS: Right maxillary first molars were extirpated from rats and implanted with either a straight-type or a step-type implant varying in step height and/or width (N(s): 0.8 mm height, 0.1 mm width; W(s): 0.8 mm height, 0.2 mm width; H(s): 0.4 mm height, 0.1 mm width). Maxillae were harvested at various time points over 16 weeks to evaluate laminin-5 distribution as an indicator of wound healing and PIE formation, horse-radish peroxidase (HRP) penetration as a measurement of epithelial sealing, and PIE down-growth formation. RESULTS: In all implant models, the PIE formed from the oral sulcular epithelium and spread apically along the implant surface. In the W(s) group, HRP penetration was detected only in the coronal region of the PIE at 4 weeks, whereas in the straight-type, it was observed in the apical region and the connective tissue. At 16 weeks, the W(s) implants exhibited markedly less PIE down-growth than the Con, N(s) or H(s) implants, and were equivalent to that observed in natural teeth. CONCLUSION: The step-type implant system may have the potential for improving epithelial sealing at the tissue-implant interface, as well as reducing apical PIE down-growth, thus enhancing dental implant efficacy.

    DOI: 10.1111/j.1600-0501.2011.02163.x

  • アテロコラーゲンをキャリアとして用いたスタチン局所投与によるインプラント周囲骨形成促進作用の検討

    益崎 与泰, 鮎川 保則, 森山 泰子, 神野 洋平, 古谷野 潔

    日本口腔インプラント学会誌   24 ( 特別号 )   284 - 284   2011.8

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  • アテロコラーゲンをキャリアとして用いたスタチン局所投与によるインプラント周囲骨形成促進作用の検討

    益崎 与泰, 鮎川 保則, 森山 泰子, 神野 洋平, 古谷野 潔

    日本口腔インプラント学会誌   24 ( 特別号 )   284 - 284   2011.8

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  • Local application of fluvastatin improves peri-implant bone quantity and mechanical properties: a rodent study. Reviewed International journal

    Moriyama Y, Ayukawa Y, Ogino Y, Atsuta I, Todo M, Takao Y, Koyano K

    Acta biomaterialia   6 ( 4 )   1610 - 1618   2010.4

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    Local application of fluvastatin improves peri-implant bone quantity and mechanical properties: a rodent study.
    Statins are known to stimulate osteoblast activity and bone formation. This study examines whether local application of fluvastatin enhances osteogenesis around titanium implants in vivo. Ten-week-old rats received a vehicle gel (propylene glycol alginate (PGA)) or PGA containing fluvastatin (3, 15, 75 or 300 microg) in their tibiae just before insertion of the implants. For both histological and histomorphometric evaluations undecalcified ground sections were obtained and the bone-implant contact (BIC), peri-implant osteoid volume and mineralized bone volume (MBV) were calculated after 1, 2 and 4 weeks. Using the same models mechanical push-in tests were also performed to evaluate the implant fixation strength. After 1 week the MBV and push-in strength were significantly lower in the 300 microg fluvastatin-treated group than in the other groups (P<0.01). At 2 weeks, however, the BIC and MBV were both significantly higher in the 75 microg fluvastatin-treated group than in the non-fluvastatin-treated groups (P<0.01). Similar tendencies were observed at week 4. Furthermore, the data showed a good correlation between the MBV and the push-in strength. These results demonstrate positive effects of locally applied fluvastatin on the bone around titanium implants and suggest that this improvement in osseointegration may be attributed to calcification of the peri-implant bone.

    DOI: 10.1016/j.actbio.2009.10.045

  • The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia. Reviewed International journal

    Masuzaki T, Ayukawa Y, Moriyama Y, Jinno Y, Atsuta I, Ogino Y, Koyano K

    Biomaterials   31 ( 12 )   3327 - 3334   2010.4

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    The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia.
    The aim of this study was to evaluate the effects of newly developed injectable poly (lactic-co-glycolic acid) (PLGA) microspheres containing fluvastatin on osteogenesis around titanium implants in the rat tibia. After confirmation of the sustained-release profile of fluvastatin from the microspheres by an in vitro assay, the microspheres were administered to the back skin of the rats by a single transdermal injection. At 2 and 4 weeks after the implant surgery, the fluvastatin groups showed enhanced new bone formation around the titanium implants without any influence on the serum biochemistry. In addition, the fluvastatin groups showed increased three-point bending strengths of their femurs. The results of this study indicate that a single remote injection of PLGA/fluvastatin microspheres safely and successfully stimulated bone formation around titanium implants and increased the mechanical properties of bone.

    DOI: 10.1016/j.biomaterials.2010.01.016

  • Simvastatin enhances bone formation around titanium implants in rat tibiae Reviewed

    Ayukawa Y, Ogino Y, Moriyama Y, Atsuta I, Jinno Y, Kihara M, Tsukiyama Y, Koyano K

    J Oral Rehabil   37 ( 2 )   123 - 130   2010.2

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    Simvastatin enhances bone formation around titanium implants in rat tibiae

    DOI: 10.1111/j.1365-2842.2009.02011.x

  • Simvastatin enhances bone formation around titanium implants in rat tibiae Reviewed

    Ayukawa Y, Ogino Y, Moriyama Y, Atsuta I, Jinno Y, Kihara M, Tsukiyama Y, Koyano K

    J Oral Rehabil   37 ( 2 )   123 - 130   2010.2

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    Simvastatin enhances bone formation around titanium implants in rat tibiae

    DOI: 10.1111/j.1365-2842.2009.02011.x

  • インプラント周囲骨形成に対するスタチン遠隔単回投与の効果 骨粗鬆症モデルラットを用いた組織学的研究

    益崎 与泰, 鮎川 保則, 森山 泰子, 熱田 生, 神野 洋平, 古谷野 潔

    日本再生歯科医学会誌   7 ( 1 )   86 - 86   2009.12

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  • インプラント周囲骨形成に対するスタチン遠隔単回投与の効果 骨粗鬆症モデルラットを用いた組織学的研究

    益崎 与泰, 鮎川 保則, 森山 泰子, 熱田 生, 神野 洋平, 古谷野 潔

    日本再生歯科医学会誌   7 ( 1 )   86 - 86   2009.12

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  • The alternation of peri-implant bone response exposed to static lateral load Reviewed

    Moriyama Y, Ayukawa Y, Kabemura K, Matsushita Y, Kihara M, Tsukiyama Y, Todo M, Takao Y, Koyano K

    J Biomech Sci Eng   4 ( 3 )   326 - 335   2009.9

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    The alternation of peri-implant bone response exposed to static lateral load

    DOI: 10.1299/jbse.4.326

  • The alternation of peri-implant bone response exposed to static lateral load Reviewed

    Moriyama Y, Ayukawa Y, Kabemura K, Matsushita Y, Kihara M, Tsukiyama Y, Todo M, Takao Y, Koyano K

    J Biomech Sci Eng   4 ( 3 )   326 - 335   2009.9

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    The alternation of peri-implant bone response exposed to static lateral load
    In the present study, peri-implant tissue alteration was studied histologically, and then differences in the gene expression pattern of certain proteins were analyzed using cDNA microarray analysis, under the influence of static lateral load. Beagle dogs were divided into two groups: control and load. Three months after the extraction of mandibular premolars, two implants were placed in each side of the mandible. Each group was further divided into subgroups for loading times of 1, 7 and 14 days. Immediately after the implant installation, a loading device was adhered between the abutments of neighboring implants. Afterward, the expansion screw of the load group was activated by 360-degree rotation, resulting in 0.7 mm horizontal expansion. After sacrificing the dogs, peri-implant tissue was collected, then microarray analysis for the detection of gene expression was performed, as well as histology. Histology indicated that the peri-implant tissue broke down under the influence of the load. Microarray analysis demonstrated the presence of load-sensitive gene expression even after 1 day. Differences in gene expression patterns in concert with static lateral load were demonstrated, even at an early stage post-operation. Further study may help in the diagnosis of pathological overload.

    DOI: 10.1299/jbse.4.326

  • [Mandibular unilateral free-end missing reconstructed by implant prosthesis].

    Yasunori Ayukawa

    Nihon Hotetsu Shika Gakkai zasshi   52 ( 4 )   586 - 9   2008.10

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  • [Mandibular unilateral free-end missing reconstructed by implant prosthesis].

    Yasunori Ayukawa

    Nihon Hotetsu Shika Gakkai zasshi   52 ( 4 )   586 - 9   2008.10

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  • プラットホームスイッチングシステムは上皮封鎖性の向上に有効か?

    熱田 生, 鮎川 保則, 荻野 洋一郎, 森山 泰子, 神野 洋平, 古橋 明大, 古谷野 潔

    日本口腔インプラント学会誌   21 ( 特別号 )   137 - 137   2008.8

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  • プラットホームスイッチングシステムは上皮封鎖性の向上に有効か?

    熱田 生, 鮎川 保則, 荻野 洋一郎, 森山 泰子, 神野 洋平, 古橋 明大, 古谷野 潔

    日本口腔インプラント学会誌   21 ( 特別号 )   137 - 137   2008.8

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  • 新規ドラッグデリバリーシステムを用いたスタチンによる骨増生

    神野 洋平, 鮎川 保則, 荻野 洋一郎, 熱田 生, 古谷野 潔

    日本口腔インプラント学会誌   21 ( 1 )   77 - 78   2008.3

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  • 新規ドラッグデリバリーシステムを用いたスタチンによる骨増生

    神野 洋平, 鮎川 保則, 荻野 洋一郎, 熱田 生, 古谷野 潔

    日本口腔インプラント学会誌   21 ( 1 )   77 - 78   2008.3

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  • Effect of the difference of bone turnover on peri-titanium implant osteogenesis in ovariectomized rats. International journal

    Akira Okamura, Yasunori Ayukawa, Shinji Iyama, Kiyoshi Koyano

    Journal of biomedical materials research. Part A   70 ( 3 )   497 - 505   2004.9

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  • Effect of the difference of bone turnover on peri-titanium implant osteogenesis in ovariectomized rats. International journal

    Akira Okamura, Yasunori Ayukawa, Shinji Iyama, Kiyoshi Koyano

    Journal of biomedical materials research. Part A   70 ( 3 )   497 - 505   2004.9

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  • 歯科インプラントと生体骨組織との界面 -表面構造の影響-

    井上 孝, 吉成 正雄, 鮎川 保則, 田中 輝男, 下野 正基

    表面技術 = The Journal of the Surface Finishing Society of Japan   49 ( 7 )   682 - 689   1998.7

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    DOI: 10.4139/sfj.49.682

  • Uncontrolled diabetes hinders bone formation around titanium implants in rat tibiae. A light and fluorescence microscopy, and image processing study Reviewed

    F Takeshita, K Murai, S Iyama, Y Ayukawa, T Suetsugu

    JOURNAL OF PERIODONTOLOGY   69 ( 3 )   314 - 320   1998.3

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  • Uncontrolled diabetes hinders bone formation around titanium implants in rat tibiae. A light and fluorescence microscopy, and image processing study Reviewed

    F Takeshita, K Murai, S Iyama, Y Ayukawa, T Suetsugu

    JOURNAL OF PERIODONTOLOGY   69 ( 3 )   314 - 320   1998.3

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  • Uncontrolled diabetes hinders bone formation around titanium implants in rat tibiae Reviewed International journal

    F. Takeshita, K. Murai, S. Iyama, Y. Ayukawa, T. Suetsugu

    A study using light, fluorescence microscopies and image processing, J Periodontol   69 ( 3 )   314 - 320   1998.1

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  • An immunocytochemical study for lysosomal cathepsins B and D related to the intracellular degradation of titanium at the bone-titanium interface Reviewed International journal

    Y. Ayukawa, F. Takeshita, M. Yoshinari, T. Inoue, Y. Ohtsuka, M. Shimono, T. Suetsugu, T. Tanaka

    J Periodontol   69 ( 1 )   62 - 68   1998.1

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  • インプラント周囲骨欠損部を被覆した3種類の膜の組織学的観察

    竹下 文隆, 鮎川 保則, 伊山 慎二, 曽根 寛之, 末次 恒夫

    日本補綴歯科學會雜誌 = The journal of the Japan Prosthodontic Society   41 ( 2 )   188 - 194   1997.4

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    The purpose of this study was to investigate the tissue reaction to three kinds of membranes, Gore-Tex Augmentation Material (GTAM), Vicryl, and Dura Mater, placed on bone defects around the titanium implants. Nine adult dogs weighing 15kg were used in this study. The dogs were sacrificed either 2, 4, or 12 weeks after placement. Vicryl was exposed 2 weeks after placement. Histologically, it was found that Vicryl was completely resorbed, Dura Mater was replaced with connective tissue at 12 weeks, and bone defects using GTAM and Dura Mater but not Vicryl were partially filled with newly-formed bone tissue. Active bone formation was observed in the space between membranes and pre-existing bone tissue.

    DOI: 10.2186/jjps.41.188

  • Abscess formation around a hydroxyapatite-coated implant placed into the extraction socket with autogenous bone graft. A histological study using light microscopy, image processing, and confocal laser scanning microscopy Reviewed

    F Takeshita, S Iyama, Y Ayukawa, T Suetsugu, M Oishi

    JOURNAL OF PERIODONTOLOGY   68 ( 3 )   299 - 305   1997.3

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  • Abscess formation around a hydroxyapatite-coated implant placed into the extraction socket with autogenous bone graft. A histological study using light microscopy, image processing, and confocal laser scanning microscopy Reviewed

    F Takeshita, S Iyama, Y Ayukawa, T Suetsugu, M Oishi

    JOURNAL OF PERIODONTOLOGY   68 ( 3 )   299 - 305   1997.3

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  • Study of bone formation around dense hydroxyapatite implants using light microscopy, image processing and confocal laser scanning microscopy Reviewed

    F Takeshita, S Iyama, Y Ayukawa, H Akedo, T Suetsugu

    BIOMATERIALS   18 ( 4 )   317 - 322   1997.2

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  • 糖尿病ラット脛骨におけるチタニウムインプラントに対する骨組織反応の組織形態学的研究

    村井 健二, 竹下 文隆, 伊山 慎二, 鮎川 保則, 末次 恒夫

    日本補綴歯科學會雜誌 = The journal of the Japan Prosthodontic Society   41 ( 1 )   94 - 99   1997.2

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    The influence of diabetes on the implant-bone interface of titanium (Ti) implants, inserted transcortically and extending into the medullary canal of rat tibiae, was examined, and the differences in bone reaction were quantitatively assessed using an image processing system. Thirty male Wister King A rats (aged 5 weeks) were used in this experiment, and they were divided into 2 groups, 15 for the control and 15 for the diabetes-induced (DI) group. They were sacrificed 7, 28 and 84 days after implant placement. Toluidine blue-stained undecalcified sections were prepared for histological observation and image analysis. The Ti implants in the bone marrow area had been almost encapsulated in a thick bone layer. The Ti implants in the DI group had been partially surrounded by a thin bone layer, but the thickness of the surrounding bone had decreased. Quantitative evaluation indicated that the control group showed an increase of the percent of bone contact, the thickness of surrounding bone and the area of surrounding bone throughout the experimental period, while the DI group showed a decrease of the thickness of surrounding bone and the area of surrounding bone except for the percent of bone contact.

    DOI: 10.2186/jjps.41.94

  • Study of bone formation around dense hydroxyapatite implants using light microscopy, image processing and confocal laser scanning microscopy Reviewed

    F Takeshita, S Iyama, Y Ayukawa, H Akedo, T Suetsugu

    BIOMATERIALS   18 ( 4 )   317 - 322   1997.2

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  • Long-term evaluation of bone-titanium interface in rat tibiae using light microscopy, transmission electron microscopy and image processing Reviewed International journal

    F. Takeshita, Y. Ayukawa, K. Murai, T. Suetsugu

    J Biomed Mater Res   37 ( 2 )   235 - 242   1997.1

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    DOI: 10.1002/(SICI)1097-4636(199711)37:2<235::AID-JBM13>3.0.CO;2-D

  • Histomorphometric analysis of the response of rat tibiae to shape memory alloy (nitinol) Reviewed International journal

    F. Takeshita, H. Takata, Y. Ayukawa, T. Suetsugu

    Biomaterials   18 ( 1 )   21 - 25   1997.1

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    DOI: 10.1016/S0142-9612(96)00051-8

  • Histological comparison of early wound healing following dense HA granule grafting and barrier placement in surgically-created bone defects neighboring implants Reviewed International journal

    F. Takeshita, Y. Ayukawa, S. Iyama, T. Suetsugu, M. Oishi

    J Periodontol   68 ( 10 )   924 - 932   1997.1

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  • A study of regional distribution of bone formed around hydroxyapatite implants in the tibiae of streptozotocin-induced diabetic rats using multiple fluorescent labeling and confocal laser scanning microscopy Reviewed International journal

    S. Iyama, F. Takeshita, Y. Ayukawa, M. A. Kido, T. Suetsugu, T. Tanaka

    J Periodontol   1997.1

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  • Effects of aging on titanium implants inserted into the tibiae of rats using light microscopy, SEM, and image processing, Reviewed International journal

    F. Takeshita, K. Murai, Y. Ayukawa, T. Suetsugu

    J Biomed Mater Res   34 ( 1 )   1 - 8   1997.1

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  • Light and electron microscopic studies of bone-titanium interface in the tibiae of young and mature rats Reviewed

    K Murai, F Takeshita, Y Ayukawa, T Kiyoshima, T Suetsugu, T Tanaka

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH   30 ( 4 )   523 - 533   1996.4

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  • Light and electron microscopic studies of bone-titanium interface in the tibiae of young and mature rats Reviewed

    K Murai, F Takeshita, Y Ayukawa, T Kiyoshima, T Suetsugu, T Tanaka

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH   30 ( 4 )   523 - 533   1996.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Fractures of hydroxyapatite-coated blade implants connected with natural teeth. A histological study using SEM, light microscopy, and an image processing system Reviewed

    F Takeshita, Y Matsushita, Y Ayukawa, T Suetsugu

    JOURNAL OF PERIODONTOLOGY   67 ( 2 )   86 - 92   1996.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Fractures of hydroxyapatite-coated blade implants connected with natural teeth. A histological study using SEM, light microscopy, and an image processing system Reviewed

    F Takeshita, Y Matsushita, Y Ayukawa, T Suetsugu

    JOURNAL OF PERIODONTOLOGY   67 ( 2 )   86 - 92   1996.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  • An ultrastructural study of the bone-titanium interface using pure titanium plastic and pure titanium rod implants Invited Reviewed International journal

    Y. Ayukawa, F. Takeshita, T. Inoue, M. Yoshinari, Y. Ohtsuka, K. Murai, M. Shimono, T. Suetsugu, T. Tanaka

    Acta Histochem Cytochem   29 ( 3 )   243 - 254   1996.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Light and electron microscopic studies of bone-titanium interface in the tibiae of young and mature rats Reviewed International journal

    K. Murai, F. Takeshita, Y. Ayukawa, T. Kiyoshima, T. Suetsugu, T. Tanaka

    J Biomed Mater Res   30 ( 4 )   523 - 533   1996.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/(SICI)1097-4636(199604)30:4<523::AID-JBM11>3.0.CO;2-I

  • Fractures of hydroxyapatite-coated blade implants connected with natural teeth. A histological study using SEM, light microscopy, and an image processing system Invited Reviewed International journal

    F. Takeshita, Y. Matsushita, Y. Ayukawa, T. Suetsugu

    J Periodontol   67 ( 2 )   86 - 92   1996.1

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  • A histologic evaluation of retrieved hydroxyapatite-coated blade form implants using scanning electron, light, and confocal laser scanning microscopies Invited Reviewed International journal

    F. Takeshita, Y. Ayukawa, S. Iyama, T. Suetsugu, M. A. Kido

    J Periodontol   67 ( 10 )   1034 - 1040   1996.1

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Books

  • 第4版 無歯顎補綴治療学

    鮎川保則他( Role: Joint author)

    医歯薬出版  2022.2 

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    Language:Japanese   Book type:Scholarly book

  • 月刊「歯界展望」別冊 10歯前後欠損症例の「読み」と「打つ手」

    鮎川保則他( Role: Joint author)

    医歯薬出版  2013.5 

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    Language:Japanese   Book type:Scholarly book

  • 審美歯科・インプラントワードブック

    古谷野潔・市川哲雄編 分担執筆者:鮎川保則他多数( Role: Joint author)

    医歯薬出版  2008.6 

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    Language:Japanese   Book type:Scholarly book

  • 目で見る咬合の基礎知識

    古谷野潔・矢谷博文・皆木省吾・佐々木啓一・渡邉誠編 分担執筆者:鮎川保則他多数( Role: Joint author)

    医歯薬出版  2002.6 

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    Language:Japanese   Book type:Scholarly book

Presentations

  • An establishment and persistence of osseointegration and peri-implant soft tissue sealing. An experimental study. Invited International conference

    Yasunori Ayukawa

    International Congress of Oral Implantologists Asia-Pacific Resion  2015.11 

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    Event date: 2015.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Cambodia  

  • インプラント埋入時の初期固定を確実にするためには? Invited

    鮎川 保則

    第45回日本口腔インプラント学会学術大会  2015.9 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:岡山市   Country:Japan  

  • The acquisition of secure peri-implant soft tissue sealing Invited International conference

    Yasunori Ayukawa

    2015 Joint Congress of JPS-CPS-KAP  2015.4 

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    Event date: 2015.4

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Temporal changes in the ultrastructural localization of bone proteins at the bone-titanium interface of rat International conference

    Ayukawa Y, Koyano K.

    Nano/Amorphous Materials and Interface Science Symposium  2009.8 

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    Event date: 2009.8

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 九州大学病院における病院情報システムリプレイスと歯科システムの評価 Invited

    鮎川 保則

    平成25年度大学病院マネジメント部門連絡会議  2014.2 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:徳島市   Country:Japan  

  • Bone engineering for dental implantology: which modalities are really potential? Invited International conference

    Ayukawa Y.

    The 6th Congress of the Asian academy of Osseointegration  2010.11 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Korea, Republic of  

  • 骨増生・骨再生の極近未来 -bench to clinic- Invited

    鮎川保則

    平成22年度日本補綴歯科学会九州支部学術講演会  2010.11 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • バイオエンジニアリングが拓く補綴歯科イノベーション -臨床ニーズに即した骨再生のストラテジー- Invited

    鮎川保則

    日本補綴歯科学会第120回記念学術大会  2011.5 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • 歯科領域におけるInterface 制御 -歯科インプラントにおけるインターフェース形成と制御- Invited

    鮎川保則

    第33回日本バイオマテリアル学会大会  2011.11 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • インプラント-生体界面の統合的理解と持続性ある界面獲得のストラテジー Invited

    鮎川 保則, 熱田 生, 古谷野 潔

    第29回歯科医学を中心とした総合的な研究を推進する集い  2013.1 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京都   Country:Japan  

  • Osseo-/Soft Tissue Integration.How Are They Established? Invited International conference

    Yasunori Ayukawa

    The First Joint Workshop on Prosthodontic Research between Shanghai JiaoTong U, Kyushu U, and Korea U  2013.4 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Korea, Republic of  

  • 上下顎臼歯部欠損に対してインプラントを用いた一症例

    鮎川保則

    第39回日本口腔インプラント学会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 高脂血症治療薬を用いた局所的骨形成の展望 Invited

    鮎川保則

    再生歯科医学シンポジウム  2007.4 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡市   Country:Japan  

  • 骨-インプラント界面の組織学的所見と生体力学的所見の関連

    鮎川保則、森山泰子、荻野洋一郎、熱田生、築山能大、古谷野潔

    日本補綴歯科学会九州支部  2007.11 

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    Presentation type:Oral presentation (general)  

    Venue:北九州市   Country:Japan  

  • 二価カチオン処理チタンに対する口腔上皮様細胞および線維芽細胞接着性の検討

    鮎川 保則, 大川内 秀幸, 古橋 明大, 熱田 生, 古谷野 潔

    第42回日本口腔インプラント学会  2012.9 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪市   Country:Japan  

  • インプラントインターフェースの構築と維持 Invited

    鮎川 保則

    第二回補綴若手研究会  2013.3 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山県倉敷市   Country:Japan  

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MISC

  • 集学的観点からインプラント治療を考える

    鮎川保則、@正木千尋、@辻光弘、@湯浅慶一郎、@武田孝之

    日本補綴歯科学会誌   2019.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: https://doi.org/10.2186/ajps.11.116

  • 組織再生と細胞・足場・生理活性物質

    鮎川保則

    顎顔面補綴   2018.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Hypothetical Model of How a Clinical Remount Procedure Benefits Patients with Existing Dentures: A Narrative Literature Review Reviewed

    #Chi-Hsiang Cheng, Ikiru Atsuta, Kiyoshi Koyano, Yasunori Ayukawa

    Healthcare (Basel)   2022.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.3390/healthcare10061067.

  • Medication-Related Osteonecrosis of the Jaw; What Should We Do as Prosthodontists?

    Shinichiro Kuroshima, Masaru Kaku, Ikiru Atsuta, Yasunori Ayukawa, Takashi Sawase

    J Prosthodont Res   2016.8

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: https://doi.org/10.1016/j.jpor.2016.01.004

  • 口腔インプラントの表面改質の現在と未来

    鮎川 保則, 熱田 生, 鶴田 勝大, 松下 恭之, 古谷野 潔

    表面技術   2016.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Soft tissue sealing around dental implants based on histological interpretation

    J Prosthodont Res   2016.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Current barrier membranes: The role and titanium mesh applications for guided bone regeneration.

    Yunia Dwi Rakhmatia, Yasunori Ayukawa, Akihiro Furuhashi, Kiyoshi Koyano

    J Prosthodont Res   2013.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Industrial property rights

Patent   Number of applications: 1   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • Asian Academy of Osseointegration

  • International Association for Dental Research

  • Japanese Association for Dental Research

  • 日本口腔インプラント学会

  • 日本補綴歯科学会

  • International Congress of Oral Implantologists

  • 日本歯科理工学会

  • 日本顎関節学会

  • 日本顎顔面補綴学会

  • 日本スポーツ歯科医学会

  • 日本口腔科学会

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Committee Memberships

  • Steering committee member   Domestic

    2023.6 - 2025.6   

  • Executive   Domestic

    2023.6 - 2025.6   

  • 日本補綴歯科学会   修練医・認定医・専門医制度委員長   Domestic

    2023.6 - 2025.6   

  • Executive   Domestic

    2022.8 - 2022.7   

  • International Congress of Oral Implantologists日本支部   専務理事   Domestic

    2022.8 - 2022.7   

  • Steering committee member   Domestic

    2022.7 - 2024.6   

  • 日本口腔インプラント学会   学術委員会副委員長   Domestic

    2022.7 - 2024.6   

  • 日本歯科理工学会   代議員   Domestic

    2022.6 - 2024.7   

  • Executive   Domestic

    2021.6 - 2023.6   

  • Steering committee member   Domestic

    2021.6 - 2023.6   

  • Steering committee member   Domestic

    2021.6 - 2023.6   

  • 日本補綴歯科学会   修練医・認定医・専門医認定委員   Domestic

    2021.6 - 2023.6   

  • 日本補綴歯科学会   教育問題検討委員長   Domestic

    2021.6 - 2023.6   

  • Steering committee member   Domestic

    2020.7 - 2022.6   

  • 日本口腔インプラント学会   学術委員会副委員長   Domestic

    2020.7 - 2022.6   

  • Steering committee member   Domestic

    2020.7 - 2020.9   

  • Steering committee member   Domestic

    2020.7 - 2020.9   

  • 日本口腔インプラント学会   優秀発表賞選考委員(ポスター)   Domestic

    2020.7 - 2020.9   

  • 日本口腔インプラント学会   優秀研究発表賞選考委員   Domestic

    2020.7 - 2020.9   

  • Steering committee member   Domestic

    2019.7 - 2020.6   

  • 日本補綴歯科学会第129回学術大会   プログラム委員   Domestic

    2019.7 - 2020.6   

  • 日本補綴歯科学会第129回学術大会   実行委員長   Domestic

    2019.7 - 2020.6   

  • Steering committee member   Domestic

    2019.6 - 2021.6   

  • 日本補綴歯科学会   学術委員会   Domestic

    2019.6 - 2021.6   

  • Steering committee member   Domestic

    2019.5   

  • 日本補綴歯科学会   第128回学術大会優秀ポスター賞審査委員   Domestic

    2019.5   

  • Steering committee member   Domestic

    2018.7 - 2020.6   

  • Steering committee member   Domestic

    2018.7 - 2020.6   

  • 日本口腔インプラント学会   研究推進委員会副委員長   Domestic

    2018.7 - 2020.6   

  • 日本口腔インプラント学会   編集委員   Domestic

    2018.7 - 2020.6   

  • Steering committee member   Domestic

    2018.6 - 2020.6   

  • 日本口腔インプラント学会   代議員   Domestic

    2018.6 - 2020.6   

  • Steering committee member   Domestic

    2017.7 - 2018.6   

  • 日本補綴歯科学会   第127回学術大会プログラム委員   Domestic

    2017.7 - 2018.6   

  • Steering committee member   Domestic

    2017.6 - 2019.6   

  • 日本補綴歯科学会   学術委員会   Domestic

    2017.6 - 2019.6   

  • Steering committee member   Domestic

    2017.6 - 2017.7   

  • 日本補綴歯科学会   課題講演優秀発表賞審査委員   Domestic

    2017.6 - 2017.7   

  • Steering committee member   Domestic

    2017.6 - 2016.7   

  • 日本補綴歯科学会   優秀ポスター賞審査委員   Domestic

    2017.6 - 2016.7   

  • Steering committee member   Domestic

    2016.7 - 2016.9   

  • 日本口腔インプラント学会   優秀発表賞選考委員   Domestic

    2016.7 - 2016.9   

  • Steering committee member   Domestic

    2016.7   

  • 日本補綴歯科学会   課題講演優秀発表賞審査委員   Domestic

    2016.7   

  • Asian Academy of Osseointegration   Councilor   Foreign country

    2016.1 - 2018.12   

  • Asian Academy of Osseointegration   Councilor   Foreign country

    2016.1 - 2018.12   

  • Steering committee member   Domestic

    2015.6 - 2017.6   

  • 日本補綴歯科学会   研究企画推進委員会   Domestic

    2015.6 - 2017.6   

  • International Congress of Oral Implantologists World Congress XXXI   Poster evaluation committee member   Foreign country

    2014.10   

  • The 9th Scientific Meeting of the Asian Academy of Osseointegration   Oral presentation evaluation committee member   Foreign country

    2014.7   

  • Steering committee member   Domestic

    2014.3 - 2018.6   

  • 日本口腔インプラント学会   学術委員   Domestic

    2014.3 - 2018.6   

  • Steering committee member   Domestic

    2013.5 - 2015.6   

  • 日本補綴歯科学会   学術委員会   Domestic

    2013.5 - 2015.6   

  • Steering committee member   Domestic

    2013.5   

  • 日本補綴歯科学会   ポスター発表優秀賞審査委員   Domestic

    2013.5   

  • Steering committee member   Domestic

    2012.5   

  • 日本補綴歯科学会   課題口演優秀賞審査委員   Domestic

    2012.5   

  • Councilor   Domestic

    2011.4 - Present   

  • Steering committee member   Domestic

    2011.4 - Present   

  • 日本補綴歯科学会   JPR編集委員会   Domestic

    2011.4 - Present   

  • Steering committee member   Domestic

    2011.4 - 2013.3   

  • 日本補綴歯科学会   ガイドライン委員会エキスパートパネル   Domestic

    2011.4 - 2013.3   

  • Steering committee member   Domestic

    2010.4 - 2013.5   

  • 日本補綴歯科学会   JPR編集委員会   Domestic

    2010.4 - 2013.5   

  • Councilor   Domestic

    2009.4 - 2013.5   

  • Steering committee member   Domestic

    2008.5 - 2012.3   

  • 日本口腔インプラント学会   査読委員   Domestic

    2008.5 - 2012.3   

  • Organizer   Domestic

    2005.4 - 2007.3   

  • 日本補綴歯科学会   国際渉外委員会   Domestic

    2005.4 - 2007.3   

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Academic Activities

  • シンポジスト

    第38回日本口腔インプラント学会中国・四国支部学術大会  ( 広島市 ) 2018.11

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    Type:Competition, symposium, etc. 

  • 特別講演演者 International contribution

    2018.11

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    Type:Competition, symposium, etc. 

  • 特別講演演者 International contribution

    2018.9

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    Type:Competition, symposium, etc. 

  • シンポジスト

    第48回日本口腔インプラント学会学術大会  ( 大阪市 ) 2018.9

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    Type:Competition, symposium, etc. 

  • シンポジスト、コーディネーター

    第60回歯科基礎医学会学術大会  ( 福岡市 ) 2018.9

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    Type:Competition, symposium, etc. 

  • 特別講演演者

    平成30年度日本補綴歯科学会九州支部学術大会  ( 熊本市 ) 2018.8

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    Type:Competition, symposium, etc. 

  • International Journal of Implant Dentistry International contribution

    2018.7 - 2020.6

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    Type:Academic society, research group, etc. 

  • シンポジスト

    第35回日本顎顔面補綴学会総会・学術大会  ( 徳島市 ) 2018.6

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    Type:Competition, symposium, etc. 

  • 課題口演審査委員

    日本補綴歯科学会第127回学術大会  ( 岡山市 ) 2018.6

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    Type:Competition, symposium, etc. 

    Number of participants:2,000

  • 座長

    日本補綴歯科学会第127回学術大会  ( 岡山市 ) 2018.6

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    Type:Competition, symposium, etc. 

    Number of participants:2,000

  • 座長(Chairmanship)

    第47回日本口腔インプラント学会  ( 仙台市 ) 2017.9

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    Type:Competition, symposium, etc. 

    Number of participants:4,000

  • 座長(Chairmanship)

    第46回日本口腔インプラント学会  ( 横浜市 ) 2016.9

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    Type:Competition, symposium, etc. 

    Number of participants:4,000

  • 座長(Chairmanship)

    第45回日本口腔インプラント学会  ( 岡山市 ) 2015.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2015.8

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本口腔インプラント学会九州支部学術大会  ( 長崎 ) 2015.1 - 2015.2

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2014.7

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    Type:Competition, symposium, etc. 

  • 運営

    第43回日本口腔インプラント学会学術大会  ( 福岡市 ) 2013.9

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    Type:Competition, symposium, etc. 

    Number of participants:4,163

  • 座長(Chairmanship)

    第43回日本口腔インプラント学会  ( 福岡市 ) 2013.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本口腔インプラント学会九州支部学術大会  ( 別府市 ) 2013.1

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第42回日本口腔インプラント学会  ( 大阪市 ) 2012.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    九州大学大学院歯学研究院プロジェクト「口腔健康科学」&「口腔組織の再生・再建医療」大学院生発表会  ( 福岡市 ) 2012.2

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第41回日本口腔インプラント学会  ( 名古屋 ) 2011.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( 福岡市 ) 2011.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第40回日本口腔インプラント学会  ( 札幌 ) 2010.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( 神戸市 ) 2007.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    「魅力ある大学院教育イニシアティブ」第2回 国際シンポジウム = 口腔顎顔面領域の発生と再生 =  ( 福岡市 ) 2007.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第29回日本口腔インプラント学会  ( 札幌 ) 1999.6 - Present

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    Type:Competition, symposium, etc. 

▼display all

Research Projects

  • 間葉系幹細胞関連疾患の概念構築と病因、治療法の解明

    Grant number:23H03092  2023 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 間葉系幹細胞由来エクソソームの解析と治療効果の検討

    Grant number:20H03879  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • インプラント治療とMesenchymal Stem Cell Aging

    Grant number:19H03843  2019 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 間葉系幹細胞を用いた自律反応型メカノセンサーの開発

    Grant number:16K15805  2016 - 2017

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • デンタルインターフェースにおける応力-セルシグナル変換の解明と個体差医療への展開

    Grant number:24249089  2015 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 未分化間葉系幹細胞を用いた力を起因とする歯科疾患の超早期自律診断と予防治療の開発

    Grant number:15H05029  2015 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • マイクロクラックから解明するオッセオインテグレーション獲得後の骨リモデリング機構

    2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • インプラントの細胞骨格制御能に注目したオッセオインテグレーションへのアプローチ

    2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • チタンをニッチとしたヒト歯肉由来間葉系幹細胞によるインプラント周囲組織の再生治療

    2014 - 2015

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 破骨細胞の分化制御を基盤としたインプラント周囲骨動態制御法の開発

    Grant number:25670823  2013 - 2014

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • チタン親和性を有する間葉系幹細胞の開発と歯科インプラント治療への応用

    Grant number:25670833  2013 - 2014

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • スタチンを応用した新規炭酸アパタイト骨補填材の開発

    2013

    科学研究費助成事業  JST研究成果最適展開支援プログラム(A-STEP)探索タイプ

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • インプラント界面成立機構の解明と機能的界面の維持に関する研究

    Grant number:24249089  2012 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • インプラント周囲軟組織封鎖性向上を目指した新規デザインの開発

    2012 - 2013

    科学研究費助成事業  JST研究成果最適展開支援プログラム(A-STEP)探索タイプ

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    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 再生医学と低結晶性炭酸アパタイトを応用した新規骨再生法の開発

    Grant number:23592889  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • チタンをニッチとした間葉系幹細胞による新規インプラント治療

    Grant number:23592888  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 骨増生の予知性を高める新規手法の開発とその効果の検討

    Grant number:23390445  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 応力によるインプラント周囲骨吸収メカニズムの解明と適切なインプラント形状の提案

    Grant number:23659903  2011 - 2012

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • ティッシュエンジニアリングの三要素から見た補綴前処置としてのテーラーメイド骨再生

    Grant number:23659902  2011 - 2012

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • チタン・生体双方へのアプローチによるインターフェースの構築・維持に関する研究

    Grant number:21390520  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 戦略的補綴治療としての補綴前骨増生を手術なしで行う手法の開発とその原理の検討

    Grant number:20390490  2008 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • インプラント周囲骨吸収に対する負担荷重の関与の解明-特に感染との関連について-

    Grant number:20659301  2008 - 2009

    科学研究費助成事業  萌芽研究

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 埋入トルク値に基づくインプラント補綴治療の新しいプロトコールの展開

    Grant number:19592247  2007 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • ドラッグデリバリーシステムを用いた新規骨再生法の開発とその細胞内メカニズムの解明

    Grant number:18390518  2006 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 接着性ペプチドの応用によるチタンの生体親和性を向上させる薬剤の開発

    Grant number:14704047  2002 - 2004

    科学研究費助成事業  若手研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

▼display all

Educational Activities

  • For undregraduate student:
    General prosthodontics and fixed prosthodontics (3rd grade); complete denture, removable partial denture and oral implantology (4th grade)
    Outline of dental sciences (1st grade) and introduction to dental sciences (6th grade)

    For graduate school student:
    Research for thesis preparation

Class subject

  • クラウンブリッジ補綴学(低年次) D

    2022.12 - 2023.2   Winter quarter

  • 部分床義歯補綴学

    2022.10 - 2023.3   Second semester

  • 口腔インプラント学

    2022.10 - 2023.3   Second semester

  • クラウンブリッジ補綴学(低年次) C

    2022.10 - 2022.12   Fall quarter

  • クラウンブリッジ補綴学(低年次) B

    2022.6 - 2022.8   Summer quarter

  • 口腔機能修復学臨床実習Ⅳ(インプラント・義歯補綴学)

    2022.4 - 2023.3   Full year

  • Integrated Dental Science(インプラント・義歯補綴学)

    2022.4 - 2023.3   Full year

  • Basic Dental Practice(インプラント・義歯補綴学)

    2022.4 - 2023.3   Full year

  • Introduction to Oral Biological Research(インプラント・義歯補綴学)

    2022.4 - 2023.3   Full year

  • Fixed Prosthodontics

    2022.4 - 2023.3   Full year

  • 歯冠補綴架工義歯学

    2022.4 - 2023.3   Full year

  • Implant and Rehabilitative Dentistry

    2022.4 - 2023.3   Full year

  • クラウンブリッジ補綴学

    2022.4 - 2023.3   Full year

  • クラウンブリッジ補綴学演習

    2022.4 - 2023.3   Full year

  • 口腔機能修復学特論(クラウンブリッジ補綴学)

    2022.4 - 2023.3   Full year

  • クラウンブリッジ補綴学臨床実習Ⅰ

    2022.4 - 2023.3   Full year

  • 口腔機能修復学臨床実習Ⅱ(クラウンブリッジ補綴学)

    2022.4 - 2023.3   Full year

  • 口腔機能修復学臨床実習Ⅳ(クラウンブリッジ補綴学)

    2022.4 - 2023.3   Full year

  • Advanced Dental Science Research(インプラント・義歯補綴学)

    2022.4 - 2023.3   Full year

  • 口腔機能修復学特論(インプラント・義歯補綴学)

    2022.4 - 2023.3   Full year

  • 口腔機能修復学臨床実習Ⅱ(インプラント・義歯補綴学)

    2022.4 - 2023.3   Full year

  • 口腔機能修復学臨床実習Ⅲ(インプラント・義歯補綴学)

    2022.4 - 2023.3   Full year

  • 全部床義歯補綴学

    2022.4 - 2022.9   First semester

  • クラウンブリッジ補綴学(低年次) A

    2022.4 - 2022.6   Spring quarter

  • 口腔インプラント学

    2021.10 - 2022.3   Second semester

  • 部分床義歯学

    2021.10 - 2022.3   Second semester

  • 歯科臨床実習

    2021.4 - 2022.3   Full year

  • 歯科臨床実習

    2021.4 - 2022.3   Full year

  • 歯冠補綴架工義歯学

    2021.4 - 2022.3   Full year

  • インプラント・義歯補綴学演習

    2021.4 - 2022.3   Full year

  • 全部床義歯学

    2021.4 - 2021.9   First semester

  • 部分床義歯学

    2018.10 - 2019.3   Second semester

  • 口腔インプラント学

    2018.10 - 2019.3   Second semester

  • 口腔機能修復学特論

    2018.4 - 2019.3   Full year

  • インプラント・義歯補綴学

    2018.4 - 2019.3   Full year

  • インプラント・義歯補綴学演習

    2018.4 - 2019.3   Full year

  • 歯科臨床実習

    2018.4 - 2019.3   Full year

  • 全部床義歯学

    2018.4 - 2018.9   First semester

  • 口腔インプラント学

    2017.10 - 2018.3   Second semester

  • 部分床義歯学

    2017.10 - 2018.3   Second semester

  • 口腔機能修復学特論

    2017.4 - 2018.3   Full year

  • インプラント・義歯補綴学

    2017.4 - 2018.3   Full year

  • インプラント・義歯補綴学演習

    2017.4 - 2018.3   Full year

  • 歯科臨床実習

    2017.4 - 2018.3   Full year

  • 全部床義歯学

    2017.4 - 2017.9   First semester

  • 部分床義歯学

    2016.10 - 2017.3   Second semester

  • 口腔インプラント学

    2016.10 - 2017.3   Second semester

  • 歯科臨床実習

    2016.4 - 2017.3   Full year

  • 口腔機能修復学特論

    2016.4 - 2017.3   Full year

  • インプラント・義歯補綴学

    2016.4 - 2017.3   Full year

  • インプラント・義歯補綴学演習

    2016.4 - 2017.3   Full year

  • 全部床義歯学

    2016.4 - 2016.9   First semester

  • 部分床義歯学

    2015.10 - 2016.3   Second semester

  • 口腔インプラント学

    2015.10 - 2016.3   Second semester

  • 歯科臨床実習

    2015.4 - 2016.3   Full year

  • 口腔機能修復学特論

    2015.4 - 2016.3   Full year

  • インプラント・義歯補綴学

    2015.4 - 2016.3   Full year

  • インプラント・義歯補綴学演習

    2015.4 - 2016.3   Full year

  • 全部床義歯学

    2015.4 - 2015.9   First semester

  • 口腔インプラント学

    2014.10 - 2015.3   Second semester

  • 部分床義歯学

    2014.10 - 2015.3   Second semester

  • 口腔機能修復学特論

    2014.4 - 2015.3   Full year

  • 歯科臨床実習

    2014.4 - 2015.3   Full year

  • インプラント・義歯補綴学演習

    2014.4 - 2015.3   Full year

  • インプラント・義歯補綴学

    2014.4 - 2015.3   Full year

  • 全部床義歯学

    2014.4 - 2014.9   First semester

  • 口腔インプラント学

    2013.10 - 2014.3   Second semester

  • 部分床義歯学

    2013.10 - 2014.3   Second semester

  • 口腔機能修復学特論

    2013.4 - 2014.3   Full year

  • 歯科臨床実習

    2013.4 - 2014.3   Full year

  • インプラント・義歯補綴学演習

    2013.4 - 2014.3   Full year

  • インプラント・義歯補綴学

    2013.4 - 2014.3   Full year

  • 生物科学II

    2013.4 - 2013.9   First semester

  • 全部床義歯学

    2013.4 - 2013.9   First semester

  • 口腔インプラント学

    2012.10 - 2013.3   Second semester

  • 部分床義歯学

    2012.10 - 2013.3   Second semester

  • 口腔機能修復学特論

    2012.4 - 2013.3   Full year

  • インプラント・義歯補綴学

    2012.4 - 2013.3   Full year

  • インプラント・義歯補綴学演習

    2012.4 - 2013.3   Full year

  • 歯科臨床実習

    2012.4 - 2013.3   Full year

  • 全部床義歯学

    2012.4 - 2012.9   First semester

  • 口腔インプラント学

    2011.10 - 2012.3   Second semester

  • 部分床義歯学

    2011.10 - 2012.3   Second semester

  • 歯科臨床実習

    2011.4 - 2012.3   Full year

  • インプラント・義歯補綴学演習

    2011.4 - 2012.3   Full year

  • インプラント・義歯補綴学

    2011.4 - 2012.3   Full year

  • 口腔機能修復学特論

    2011.4 - 2012.3   Full year

  • 全部床義歯学

    2011.4 - 2011.9   First semester

  • 部分床義歯学

    2010.10 - 2011.3   Second semester

  • 咀嚼機能再建学

    2010.4 - 2011.3   Full year

  • 咀嚼機能再建学演習

    2010.4 - 2011.3   Full year

  • 口腔機能修復学特論

    2010.4 - 2011.3   Full year

  • 歯科臨床実習

    2010.4 - 2011.3   Full year

  • 全部床義歯学

    2010.4 - 2010.9   First semester

  • 部分床義歯学

    2009.10 - 2010.3   Second semester

  • 歯科臨床実習

    2009.4 - 2010.3   Full year

  • 咀嚼機能再建学演習

    2009.4 - 2010.3   Full year

  • 口腔機能修復学特論

    2009.4 - 2010.3   Full year

  • 咀嚼機能再建学

    2009.4 - 2010.3   Full year

  • 部分床義歯学

    2008.10 - 2009.3   Second semester

  • 歯科臨床実習

    2008.4 - 2009.3   Full year

  • 口腔機能修復学特論

    2008.4 - 2009.3   Full year

  • 咀嚼機能再建学演習

    2008.4 - 2009.3   Full year

  • 咀嚼機能再建学

    2008.4 - 2009.3   Full year

  • 全部床義歯学

    2008.4 - 2008.9   First semester

  • 部分床義歯学

    2007.10 - 2008.3   Second semester

  • 歯科臨床実習

    2007.4 - 2008.3   Full year

  • 咀嚼機能再建学

    2007.4 - 2008.3   Full year

  • 口腔機能修復学特論

    2007.4 - 2008.3   Full year

  • 咀嚼機能再建学演習

    2007.4 - 2008.3   Full year

  • 全部床義歯学

    2007.4 - 2007.9   First semester

  • 部分床義歯学

    2006.10 - 2007.3   Second semester

  • 総合歯科学

    2006.10 - 2007.3   Second semester

  • 歯科臨床実習

    2006.4 - 2007.3   Full year

  • 口腔機能修復学特論

    2006.4 - 2007.3   Full year

  • 咀嚼機能再建学

    2006.4 - 2007.3   Full year

  • 咀嚼機能再建学演習

    2006.4 - 2007.3   Full year

  • 全部床義歯学

    2006.4 - 2006.9   First semester

▼display all

FD Participation

  • 2020.6   Role:Participation   Title:ジャーナルをめぐる世界的な動向と論文の投稿・入手

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.5   Role:Participation   Title:一斉技能試験について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.3   Role:Participation   Title:東京医歯大における国家試験対策の実践

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.6   Role:Participation   Title:国立大学改革プランへの対応・東医歯大歯学部改革への取り組み

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.12   Role:Participation   Title:歯学教育の認証評価

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.9   Role:Participation   Title:歯学教育の現状と課題/科学研究費改革の方向性

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.3   Role:Participation   Title:Comparisons between US and European Dental Schools – finances, research and clinical experience

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.2   Role:Participation   Title:誤飲・誤嚥のセミナー

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.10   Role:Participation   Title:プロフェッショナリズム教育 ―特に卒前教育について、授業を紹介しながら―

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.9   Role:Participation   Title:科研費獲得のポイント

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2013.10   Role:Participation   Title:PBLとチューターの役割―昭和大学の学部連携PBLの紹介―

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.9   Role:Participation   Title:PBLチュートリアル チューター講習会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.9   Role:Participation   Title:Active Learning とPBLチュートリアル教育

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.9   Role:Participation   Title:東日本大震災 歯科医療従事者派遣活動報告

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role:Participation   Title:昭和大学におけるPBL-チュートリアルの取り組み

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.12   Role:Participation   Title:カリキュラムプランニングの基礎 ―目標・方略・評価―

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.12   Role:Participation   Title:学び方を学ぶPBLチュートリアル

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.3   Role:Participation   Title:歯学研究院の次期中期目標・計画について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.1   Role:Participation   Title:化学物質の安全管理対策

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.9   Role:Participation   Title:歯学研究院QUEST-MAPの最終案について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.8   Role:Participation   Title:綱紀粛正について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.4   Role:Participation   Title:歯学研究院のQUEST-MAP(最終版)について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2008.10   Role:Participation   Title:患者の肖像権と個人情報保護

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2008.3   Role:Planning   Title:歯学研究院の現状と将来構想(QUEST-MAP)について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2008.1   Role:Participation   Title:歯科医療領域の政策・経営シンクタンク

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.12   Role:Planning   Title:歯学研究院の理念について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.12   Role:Participation   Title:香港大学歯学部のPBL教育の実際- External Examinerとしての経験から-

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.7   Role:Participation   Title:歯学研究院の課題とその解決策

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.5   Role:Participation   Title:歯学を取り巻く現状分析(その1)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.4   Role:Participation   Title:歯学研究院の将来を考えるプロジェクト設置について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.1   Role:Participation   Title:「新しい教員組織のあり方について」、「任期制について」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2006.7   Role:Participation   Title:任期制における中間評価について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2006.3   Role:Participation   Title:任期制の中間評価について、歯学研究院の現状について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2003.10   Role:Participation   Title:卒前・卒直後臨床実習について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2003.1   Role:Participation   Title:パネルディスカッション2

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2002.11   Role:Participation   Title:パネルディスカッション1

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2002.10   Role:Participation   Title:臨床能力評価法としてのOSCEの有用性について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2002.5   Role:Participation   Title:米国州立大学及び私立大学歯学部の教育・研究・臨床

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2002.4   Role:Participation   Title:九大歯学府におけるeラーニング

    Organizer:[Undergraduate school/graduate school/graduate faculty]

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2023  長崎大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2023  九州歯科大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2023  岡山大学歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期

  • 2023  北海道大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2023  徳島大学歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2022  徳島大学歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2022  岡山大学歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期

  • 2022  北海道大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  徳島大学歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2021  岡山大学歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期

  • 2020  徳島大学歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

▼display all

Other educational activity and Special note

  • 2021  Class Teacher 

  • 2021  Special Affairs 

  • 2020  Special Affairs 

  • 2019  Special Affairs 

Outline of Social Contribution and International Cooperation activities

  • 溝辺学園 大分県歯科技術専門学校 非常勤講師
    福岡医健専門学校 非常勤講師
    九州大学歯学部同窓会理事(学術担当)
    マルメ大学歯学部 共同研究

Social Activities

  • 歯科技工士国家試験委員

    2022

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    歯科技工士国家試験委員

  • 歯科技工士国家試験委員

    2021

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    歯科技工士国家試験委員

  • 歯科技工士国家試験委員

    2020

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    歯科技工士国家試験委員

  • 歯科技工士国家試験委員

    2019

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    歯科技工士国家試験委員

  • 歯科技工士国家試験委員

    2018

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    歯科技工士国家試験委員

Travel Abroad

  • 2016.3

    Staying countory name 1:Sweden   Staying institution name 1:Malmo University

  • 2012.6 - 2012.8

    Staying countory name 1:United States   Staying institution name 1:University of Iowa

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Dentistry / Prosthetic Science and Engineering Dentistry

Clinician qualification

  • Specialist

    日本口腔インプラント学会

  • Specialist

    日本補綴歯科学会

  • Preceptor

    日本補綴歯科学会

Year of medical license acquisition

  • 1993