Updated on 2024/12/08

Information

 

写真a

 
UEHARA NORIHISA
 
Organization
Faculty of Dental Science Department of Dental Science Assistant Professor
School of Dentistry Department of Dentistry(Concurrent)
Graduate School of Dental Science Department of Dental Science(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926426307
Profile
1. 細胞外小胞を介した癌細胞ー骨代謝細胞間コミュニケーション機序の解明。 2. 老化骨細胞の力学的刺激応答:特異的分泌因子を介した骨・臓器ネットワークの解明。 3. 歯学部学生・大学院生対象の講義・実習。
External link

Research Areas

  • Life Science / Cell biology

Degree

  • Ph.D.

Research History

  • Kyushu University Assistant Professor

    2013.1 - Present

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    Country:Japan

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  • Lawrence Berkeley National Laboratory Life Sciences Division (Dr. Shyamala Harris Lab) Academic Researcher

  • 関西医科大学 病理学第二講座 講師

Research Interests・Research Keywords

  • Research theme:Alterations in mechanosensitivity during osteocyte senescence:

    Keyword:cellular senescence, osteocyte, mechanosensitivity, intercellular communication

    Research period: 2021.1

  • Research theme:Roles of cancer cell-derived extracellular vesicles in the regulation of differentiation and function of bone resident cells.

    Keyword:extracellular vesicles, microRNA, bone metastasis, osteoclasts, osteoblasts

    Research period: 2015.4

  • Research theme:Identification of tumor suppressive miRNAs induced by histone deacetylase inhibitor vorinostat in human breast cancer cells

    Keyword:HDAC inhibitor, Cancer, microRNA

    Research period: 2007.4 - 2016.3

Awards

  • 福井敏がん・医療研究

    2011.4   大阪コミュニティ財団  

  • 平成20年度 大阪対ガン協会研究奨励賞

    2008.3   大阪対ガン協会  

  • 平成19年度 大阪対ガン協会研究奨励賞

    2007.3   大阪対ガン協会  

  • 平成18年度 大阪対ガン協会研究奨励賞

    2006.3   大阪対ガン協会  

Papers

  • Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling Reviewed International journal

    Norihisa Uehara, Nobuhide Shibusawa, Yoshikazu Mikami, Yukari Kyumoto-Nakamura, Soichiro Sonoda, Hiroki Kato, Takayoshi Yamaza, Toshio Kukita

    Archives of Biochemistry and Biophysics   750   109821   2023.12   ISSN:0003-9861 eISSN:1096-0384

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.abb.2023.109821

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  • miR-92a-3p encapsulated in bone metastatic mammary tumor cell-derived extracellular vesicles modulates mature osteoclast longevity Reviewed International journal

    Norihisa Uehara, Yukari Kyumoto-Nakamura, Yoshikazu Mikami, Manabu Hayatsu, Soichiro Sonoda, Takayoshi Yamaza, Akiko Kukita, Toshio Kukita

    Cancer Science   113 ( 12 )   4219 - 4229   2022.12   ISSN:1347-9032 eISSN:1349-7006

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    Aberrant osteoclast formation and activation are the hallmarks of osteolytic metastasis. Extracellular vesicles (EVs), released from bone metastatic tumor cells, play a pivotal role in the progression of osteolytic lesions. However, the mechanisms through which tumor cell–derived EVs regulate osteoclast differentiation and function have not been fully elucidated. In this study, we found that 4T1 bone metastatic mouse mammary tumor cell–derived EVs (4T1-EVs) are taken up by mouse bone marrow macrophages to facilitate osteoclastogenesis. Furthermore, treatment of mature osteoclasts with 4T1-EVs promoted bone resorption, which was accompanied by enhanced survival of mature osteoclasts through the negative regulation of caspase-3. By comparing the miRNA content in 4T1-EVs with that in 67NR nonmetastatic mouse mammary tumor cell–derived EVs (67NR-EVs), miR-92a-3p was identified as one of the most enriched miRNAs in 4T1-EVs, and its transfer into mature osteoclasts significantly reduced apoptosis. Bioinformatic and Western blot analyses revealed that miR-92a-3p directly targeted phosphatase and tensin homolog (PTEN) in mature osteoclasts, resulting in increased levels of phospho-Akt. Our findings provide novel insights into the EV-mediated regulation of osteoclast survival through the transfer of miR-92a-3p, which enhances mature osteoclast survival via the Akt survival signaling pathway, thus promoting bone resorption.

    DOI: 10.1111/cas.15557

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  • Osteoblast-derived Laminin-332 is a novel negative regulator of osteoclastogenesis in bone microenvironments Reviewed

    Norihisa Uehara, Akiko Kukita, Yukari Kyumoto, Takayoshi Yamaza, Hisataka Yasuda, Toshio Kukita

    Laboratory Investigation   97 ( 10 )   1235 - 1244   2017.10

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    DOI: 10.1038/labinvest.2017.55

  • Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells Reviewed

    Norihisa Uehara, Katsuhiko Yoshizawa, Airo Tsubura

    Oncology Reports   28 ( 1 )   105 - 110   2012.7

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    DOI: 10.3892/or.2012.1758

  • Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells Reviewed

    Hisanori Miki, Norihisa Uehara, Ayako Kimura, Tomo Sasaki, Takashi Yuri, Katsuhiko Yoshizawa, Airo Tsubura

    International Journal of Oncology   40 ( 4 )   1020 - 1028   2012.4

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    DOI: 10.3892/ijo.2012.1325

  • Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells Reviewed

    Norihisa Uehara, Sayaka Kanematsu, Hisanori Miki, Katsuhiko Yoshizawa, Airo Tsubura

    Cancer Letters   315 ( 2 )   112 - 121   2012.2

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    DOI: 10.1016/j.canlet.2011.07.032

  • ヒストン脱アセチル化酵素阻害剤vorinostatによるp38MAPキナーゼシグナルを介した乳癌細胞死誘導機序 Reviewed

    上原範久, 兼松清果, 三城弥範, 義澤克彦, 螺良愛郎

    乳癌基礎研究   20   17 - 21   2011.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells Reviewed

    Sayaka Kanematsu, Norihisa Uehara, Hisanori Miki, Katsuhiko Yoshizawa, Ayako Kawanaka, Takashi Yuri, Airo Tsubura

    Anticancer Research   30 ( 9 )   3381 - 3390   2010.9

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  • Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells Reviewed

    Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura

    Molecular Cancer Research   6 ( 2 )   186 - 193   2008.2

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    DOI: 10.1158/1541-7786.MCR-07-0254

  • Mesothelin過剰発現乳癌細胞株における足場非依存的増殖促進とERKシグナル経路を介したアノイキス抑制機序 Reviewed

    上原範久、松岡洋一郎、螺良愛郎

    乳癌基礎研究   17   21 - 25   2008.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Parous mammary glands exhibit distinct alterations in gene expression and proliferation responsiveness to carcinogenic stimuli in Lewis rats Reviewed

    Norihisa Uehara, Akira Unami, Yasuhiko Kiyozuka, Nobuaki Shikata, Yuji Oishi, Airo Tsubura

    Oncology Reports   15 ( 4 )   903 - 911   2006.4

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  • Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADP-ribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition Reviewed

    Norihisa Uehara, Katsuaki Miki, Reiko Tsukamoto, Yoichiro Matsuoka, Airo Tsubura

    Experimental Eye Research   82 ( 3 )   488 - 495   2006.3

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    DOI: 10.1016/j.exer.2005.08.006

  • Id-1 is not expressed in the luminal epithelial cells of mammary glands Reviewed

    Norihisa Uehara, Yu Chien Chou, Jose J. Galvez, Paola de-Candia, Robert D. Cardiff, Robert Benezra, Gopalan Shyamala

    Breast Cancer Research   5 ( 2 )   2003.4

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    DOI: 10.1186/bcr560

  • Mammary epithelial cells of PR-A transgenic mice exhibit distinct alterations in gene expression and growth potential associated with transformation Reviewed

    Yu Chien Chou, Norihisa Uehara, Jason R. Lowry, G. Shyamala

    Carcinogenesis   24 ( 3 )   403 - 409   2003.3

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    DOI: 10.1093/carcin/24.3.403

  • Subtractive screening of genes involved in cellular senescence Reviewed

    Norihisa Uehara, Yoshinori Katakura, Takumi Miura, Sanetaka Shirahata

    Cytotechnology   35 ( 1 )   35 - 42   2001.1

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    DOI: 10.1023/A:1008103230335

  • Identification of specific genes involved in cellular senescence by using human lung adenocarcinoma derived cells Invited Reviewed International journal

    Uehara, N. Katakura, Y. Nishimoto, S. Teruya, K. Shirahata, S.

    Animal Cell Technology: Basic & Applied Aspects   Vol 10   375 - 379   1999.1

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  • Molecular cloning and characterization of specific genes involved in cellular senescence Invited Reviewed International journal

    Uehara, N. Katakura, Y. Miura, T. Shirahata, S.

    Animal Cell Technology: Challenges for the 21st Century   1999.1

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  • NaV1.1 contributes to the cell cycle of human mesenchymal stem cells by regulating AKT and CDK2

    Zakaria, MF; Kato, H; Sonoda, S; Kato, K; Uehara, N; Kyumoto-Nakamura, Y; Sharifa, MM; Yu, LT; Dai, LS; Yamaza, H; Kajioka, S; Nishimura, F; Yamaza, T

    JOURNAL OF CELL SCIENCE   137 ( 19 )   2024.10   ISSN:0021-9533 eISSN:1477-9137

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    Non-excitable cells express sodium voltage-gated channel alpha subunit 1 gene and protein (known as SCN1A and NaV1.1, respectively); however, the functions of NaV1.1 are unclear. In this study, we investigated the role of SCN1A and NaV1.1 in human mesenchymal stem cells (MSCs). We found that SCN1A was expressed in MSCs, and abundant expression of NaV1.1 was observed in the endoplasmic reticulum; however, this expression was not found to be related to Na+ currents. SCN1A-silencing reduced MSC proliferation and delayed the cell cycle in the S phase. SCN1A silencing also suppressed the protein levels of CDK2 and AKT (herein referring to total AKT), despite similar mRNA expression, and inhibited AKT phosphorylation in MSCs. A cycloheximide-chase assay showed that SCN1A-silencing induced CDK2 but not AKT protein degradation in MSCs. A proteolysis inhibition assay using epoxomicin, bafilomycin A1 and NH4Cl revealed that both the ubiquitin–proteasome system and the autophagy and endo-lysosome system were irrelevant to CDK2 and AKT protein reduction in SCN1A-silenced MSCs. The AKT inhibitor LY294002 did not affect the degradation and nuclear localization of CDK2 in MSCs. Likewise, the AKT activator SC79 did not attenuate the SCN1A-silencing effects on CDK2 in MSCs. These results suggest that NaV1.1 contributes to the cell cycle of MSCs by regulating the post-translational control of AKT and CDK2.

    DOI: 10.1242/jcs.261732

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  • Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease

    Zakaria MHD. Fouad, Sonoda Soichiro, Kato Hiroki, Ma Lan, Uehara Norihisa, Kyumoto Yukari, Sharifa M. Majd, Yu Liting, Dai Lisha, Yamauchi Erika, Aijima Reona, Yamaza Haruyoshi, Nishimura Fusanori, Yamaza Takayoshi

    Scientific Reports   14   6719   2024.3   eISSN:20452322

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    Alveolar bone loss caused by periodontal disease eventually leads to tooth loss. Periodontal ligament stem cells (PDLSCs) are the tissue-specific cells for maintaining and repairing the periodontal ligament, cementum, and alveolar bone. Here, we investigated the role of erythropoietin receptor (EPOR), which regulates the microenvironment-modulating function of mesenchymal stem cells, in PDLSC-based periodontal therapy. We isolated PDLSCs from patients with chronic periodontal disease and healthy donors, referred to as PD-PDLSCs and Cont-PDLSCs, respectively. PD-PDLSCs exhibited reduced potency of periodontal tissue regeneration and lower expression of EPOR compared to Cont-PDLSCs. EPOR-silencing suppressed the potency of Cont-PDLSCs mimicking PD-PDLSCs, whereas EPO-mediated EPOR activation rejuvenated the reduced potency of PD-PDLSCs. Furthermore, we locally transplanted EPOR-silenced and EPOR-activated PDLSCs into the gingiva around the teeth of ligament-induced periodontitis model mice and demonstrated that EPOR in PDLSCs participated in the regeneration of the periodontal ligament, cementum, and alveolar bone in the ligated teeth. The EPOR-mediated paracrine function of PDLSCs maintains periodontal immune suppression and bone metabolic balance via osteoclasts and osteoblasts in the periodontitis model mice. Taken together, these results suggest that EPOR signaling is crucial for PDLSC-based periodontal regeneration and paves the way for the development of novel options for periodontal therapy.

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  • Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease. Reviewed International journal

    Mhd Fouad Zakaria, Soichiro Sonoda, Hiroki Kato, Lan Ma, Norihisa Uehara, Yukari Kyumoto-Nakamura, M Majd Sharifa, Liting Yu, Lisha Dai, Erika Yamauchi-Tomoda, Reona Aijima, Haruyoshi Yamaza, Fusanori Nishimura, Takayoshi Yamaza

    Scientific reports   14 ( 1 )   6719 - 6719   2024.3   ISSN:2045-2322

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    Alveolar bone loss caused by periodontal disease eventually leads to tooth loss. Periodontal ligament stem cells (PDLSCs) are the tissue-specific cells for maintaining and repairing the periodontal ligament, cementum, and alveolar bone. Here, we investigated the role of erythropoietin receptor (EPOR), which regulates the microenvironment-modulating function of mesenchymal stem cells, in PDLSC-based periodontal therapy. We isolated PDLSCs from patients with chronic periodontal disease and healthy donors, referred to as PD-PDLSCs and Cont-PDLSCs, respectively. PD-PDLSCs exhibited reduced potency of periodontal tissue regeneration and lower expression of EPOR compared to Cont-PDLSCs. EPOR-silencing suppressed the potency of Cont-PDLSCs mimicking PD-PDLSCs, whereas EPO-mediated EPOR activation rejuvenated the reduced potency of PD-PDLSCs. Furthermore, we locally transplanted EPOR-silenced and EPOR-activated PDLSCs into the gingiva around the teeth of ligament-induced periodontitis model mice and demonstrated that EPOR in PDLSCs participated in the regeneration of the periodontal ligament, cementum, and alveolar bone in the ligated teeth. The EPOR-mediated paracrine function of PDLSCs maintains periodontal immune suppression and bone metabolic balance via osteoclasts and osteoblasts in the periodontitis model mice. Taken together, these results suggest that EPOR signaling is crucial for PDLSC-based periodontal regeneration and paves the way for the development of novel options for periodontal therapy.

    DOI: 10.1038/s41598-024-57361-y

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  • Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease Reviewed International journal

    Mhd Fouad Zakaria, Soichiro Sonoda, Hiroki Kato, Lan Ma, Norihisa Uehara, Yukari Kyumoto-Nakamura, M Majd Sharifa, Liting Yu, Lisha Dai, Erika Yamauchi-Tomoda, Reona Aijima, Haruyoshi Yamaza, Fusanori Nishimura, Takayoshi Yamaza

    Scientific Reports   6719 ( 14 )   2024.3

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    DOI: 10.1038/s41598-024-57361-y.

  • 骨転移乳癌細胞由来細胞外小胞に封入されたmiR-92a-3pは成熟破骨細胞の寿命を調節する(miR-92a-3p encapsulated in bone metastatic mammary tumor cell-derived extracellular vesicles modulates mature osteoclast longevity)

    Uehara Norihisa, Kyumoto-Nakamura Yukari, Mikami Yoshikazu, Hayatsu Manabu, Sonoda Soichiro, Yamaza Takayoshi, Kukita Akiko, Kukita Toshio

    Cancer Science   113 ( 12 )   4219 - 4229   2022.12   ISSN:1347-9032

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    骨転移乳癌細胞由来細胞外小胞(EV)が破骨細胞の分化や機能に及ぼす影響とそのメカニズムについて検討した。マウス乳癌細胞株4T1由来EV(4T1-EV)がマウス骨髄マクロファージに取り込まれ、破骨細胞形成を促進することを見出した。成熟破骨細胞を4T1-EVで処理すると、骨吸収が促進され、カスパーゼ3を負に制御して成熟破骨細胞の生存が促進された。4T1-EVと非転移性マウス乳癌細胞株67NR由来EV(67NR-EV)におけるmiRNAの内容を比較した。その結果、miR-92a-3pが4T1-EVに最も濃縮されたmiRNAの一つとして特定され、miR-92a-3pの成熟破骨細胞への移入によりアポトーシスが著しく抑制された。さらに、miR-92a-3pは成熟破骨細胞においてphosphatase and tensin homolog(PTEN)を直接標的とし、リン酸化Aktのレベルを増加させた。以上より、マウス乳癌細胞株4T1由来EVに存在するmiR-92a-3pは、Akt生存シグナル経路を介して成熟破骨細胞の生存を高め、骨吸収を促進させることが示された。

  • Modulation of Osteoclastogenesis through Adrenomedullin Receptors on Osteoclast Precursors: Initiation of Differentiation by Asymmetric Cell Division Reviewed International journal

    Toshio Kukita, Hidenobu Hiura, Jiong-Yan Gu, Yukari Kyumoto-Nakamura, Jing-Qi Zhang, Norihisa Uehara, Sara Murata, Soichiro Sonoda, Takayoshi Yamaza, Ichiro Takahashi, and Akiko Kukita

    Laboratory Investigation   101 ( 11 )   1449 - 1457   2021.9

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  • Exosomes Derived from Fisetin-treated Keratinocytes Mediate Hair Growth Promotion Invited Reviewed International journal

    Mizuki Ogawa, Miyako Udono, Kiichiro Teruya, Norihisa Uehara, Yoshinori Katakura

    Nutrients   13 ( 6 )   2087   2021.6

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  • Targeting of Deciduous Tooth Pulp Stem Cell-Derived Extracellular Vesicles on Telomerase-Mediated Stem Cell Niche and Immune Regulation in Systemic Lupus Erythematosus Invited Reviewed International journal

    Soichiro Sonoda, Sara Murata, Hiroki Kato, Fouad Zakaria, Yukari Kyumoto-Nakamura, Norihisa Uehara, Haruyoshi Yamaza, Toshio Kukita, Takayoshi Yamaza

    The Journal of Immunology   206 ( 12 )   3053 - 3063   2021.4

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  • In vitro and in vivo detection of tunneling nanotubes in normal and pathological osteoclastogenesis involving osteoclast fusion Invited Reviewed International journal

    Jing-Qi Zhang, Akira Takahashi, Jiong-Yan Gu, Xiaoxu Zhang, Yukari Kyumoto-Nakamura, Akiko Kukita, Norihisa Uehara, Hidenobu Hiura, Takayoshi Yamaza, and Toshio Kukita

    Laboratory Investigation   101 ( 12 )   1571 - 1584   2021.4

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  • Fisetin Promotes Hair Growth by Augmenting TERT Expression Reviewed International journal

    Chisato Kubo, Mizuki Ogawa, Norihisa Uehara, Yoshinori Katakura

    Frontiers in Cell and Developmental Biology   8   2020.10

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    DOI: 10.3389/fcell.2020.566617

  • Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model Reviewed

    Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita, Takayoshi Yamaza

    Stem Cell Research and Therapy   11 ( 1 )   2020.7

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    DOI: 10.1186/s13287-020-01818-0

  • Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model Invited Reviewed International journal

    Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita, Takayoshi Yamaza

    Stem Cell Research and Therapy   11 ( 1 )   296   2020.7

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    DOI: 10.1186/s13287-020-01818-0

  • Osteoblast lineage-specific cell-surface antigen (A7) regulates osteoclast recruitment and calcification during bone remodeling Reviewed International journal

    Badawy, T. Kyumoto-Nakamura, Y. Uehara, N. Zhang, J. Sonoda, S. Hiura, H. Yamaza, T. Kukita, A. Kukita, T.

    Laboratory Investigation   99 ( 6 )   866 - 884   2019.6

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    DOI: 10.1038/s41374-018-0179-4

  • Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla Reviewed

    Yosuke Tanaka, Soichiro Sonoda, Haruyoshi Yamaza, Sara Murata, Kento Nishida, Yukari Kyumoto-Nakamura, Norihisa Uehara, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza

    Journal of Endodontics   45 ( 5 )   591 - 598.e6   2019.5

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    DOI: 10.1016/j.joen.2019.01.016

  • Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla Reviewed International journal

    Tanaka, Y. Sonoda, S. Yamaza, H. Murata, S. Nishida, K. Hama, S. Kyumoto-Nakamura, Y. Uehara, N. Nonaka, K. Kukita, T. Yamaza, T.

    Stem Cell Res Ther   9 ( 1 )   334   2018.11

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    DOI: 10.1186/s13287-018-1077-9

  • Unique Osteoblast-Specific Cell-Surface Antigen Useful for Odontoblast Ontology and Dentin Regeneration Reviewed International journal

    Badawy, T. Kyumoto-Nakamura, Y. Uehara, N. Zhang, J. Hiura, H. Sonoda, S. Yamaza, T. Kukita, A. Kukita, T.

    Oral Health & Dental Science   2018.11

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    DOI: 10.1038/s41374-018-0179-4

  • Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells Reviewed

    Soichiro Sonoda, Yu Feng Mei, Atsuta Ikiru, Atsushi Danjo, Haruyoshi Yamaza, Shion Hama, Kento Nishida, Ronghao Tang, Yukari Kyumoto, Norihisa Uehara, Toshio Kukita, Fusanori Nishimura, Takayoshi Yamaza

    Scientific Reports   8 ( 1 )   2018.2

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    DOI: 10.1038/s41598-018-21183-6

  • IL-1β induces pathologically activated osteoclasts bearing extremely high levels of resorbing activity A possible pathological subpopulation of osteoclasts, accompanied by suppressed expression of kindlin-3 and Talin-1 Reviewed

    200 ( 1 )   218 - 228   2018.1

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    DOI: 10.4049/jimmunol.1602035

  • Correction MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma (PLoS ONE (2017) 12:6 (e0180317) DOI: 10.1371/journal.pone.0085935) Reviewed

    Ombretta Melaiu, Justin Stebbing, Ylenia Lombardo, Elisa Bracci, Norihisa Uehara, Alessandra Bonotti, Alfonso Cristaudo, Rudy Foddis, Luciano Mutti, Roberto Barale, Federica Gemignani, Georgios Giamas, Stefano Landi

    PLoS One   12 ( 6 )   2017.6

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    DOI: 10.1371/journal.pone.0180317

  • Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis Reviewed

    Toshio Takano, Yin Ji Li, Akiko Kukita, Takayoshi Yamaza, Yasunori Ayukawa, Kanako Moriyama, Norihisa Uehara, Hisayuki Nomiyama, Kiyoshi Koyano, Toshio Kukita

    Laboratory Investigation   94 ( 3 )   286 - 296   2014.3

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    DOI: 10.1038/labinvest.2013.152

  • MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma Reviewed

    Ombretta Melaiu, Justin Stebbing, Ylenia Lombardo, Elisa Bracci, Norihisa Uehara, Alessandra Bonotti, Alfonso Cristaudo, Rudy Foddis, Luciano Mutti, Roberto Barale, Federica Gemignani, Georgios Giamas, Stefano Landi

    PLoS One   9 ( 1 )   2014.1

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    DOI: 10.1371/journal.pone.0085935

  • Regulation of osteoclastogenesis through Tim-3 Possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction Reviewed

    Kanako Moriyama, Akiko Kukita, Yin Ji Li, Norihisa Uehara, Jing Qi Zhang, Ichiro Takahashi, Toshio Kukita

    Laboratory Investigation   94 ( 11 )   1200 - 1211   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/labinvest.2014.107

  • Curcumin suppresses n-methyl-n-nitrosourea-induced photoreceptor apoptosis in sprague-dawley rats Reviewed

    Yuko Emoto, Katsuhiko Yoshizawa, Norihisa Uehara, Yuichi Kinoshita, Takashi Yuri, Nobuaki Shikata, Airo Tsubura

    In Vivo   27 ( 5 )   583 - 590   2013.9

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  • N-Methyl-N-nitrosourea-induced renal tumors in rats Immunohistochemical comparison to human Wilms tumors Reviewed

    Katsuhiko Yoshizawa, Yuichi Kinoshita, Yuko Emoto, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Airo Tsubura

    Journal of Toxicologic Pathology   26 ( 2 )   141 - 148   2013.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1293/tox.26.141

  • Histopathological and immunohistochemical characterization of spontaneously occurring uterine deciduomas in young adult rats Reviewed International journal

    Katsuhiko Yoshizawa, Yuko Emoto, Yuichi Kinoshita, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Airo Tsubura

    Journal of Toxicologic Pathology   26 ( 1 )   61 - 66   2013.6

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    DOI: 10.1293/tox.26.61

  • Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal Preneoplastic lesions in young Lewis rats Reviewed

    Katsuhiko Yoshizawa, Yuko Emoto, Yuichi Kinoshita, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Tomohito Hamazaki, Airo Tsubura

    Oncology Letters   5 ( 4 )   1112 - 1116   2013.4

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    DOI: 10.3892/ol.2013.1162

  • Arachidonic acid supplementation during gestational, lactational and post-weaning periods prevents retinal degeneration induced in a rodent model Reviewed

    Katsuhiko Yoshizawa, Tomo Sasaki, Maki Kuro, Norihisa Uehara, Hideho Takada, Akiko Harauma, Naoki Ohara, Toru Moriguchi, Airo Tsubura

    British Journal of Nutrition   109 ( 8 )   1424 - 1432   2013.4

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    DOI: 10.1017/S0007114512003327

  • Two cases of malignant peritoneal mesothelioma without asbestos exposure Cytologic and immunohistochemical features Reviewed

    Yuichi Kinoshita, Kosho Takasu, Takashi Yuri, Katsuhiko Yoshizawa, Norihisa Uehara, Ayako Kimura, Hisanori Miki, Airo Tsubura, Nobuaki Shikata

    Annals of Diagnostic Pathology   17 ( 1 )   99 - 103   2013.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.anndiagpath.2012.05.007

  • Promoting effect of arachidonic acid supplementation on N-methyl-N-nitrosourea--induced pancreatic acinar cell hyperplasia in young Lewis rats Reviewed

    Katsuhiko Yoshizawa, Norihisa Uehara, Ayako Kimura, Yuko Emoto, Yuichi Kinoshita, Takashi Yuri, Hideho Takada, Toru Moriguchi, Tomohito Hamazaki, Airo Tsubura

    Oncology Letters   5 ( 1 )   76 - 82   2013.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ol.2012.1009

  • N-methyl-N-nitrosourea-induced changes in epithelial rests of Malassez and the development of odontomas in rats Reviewed

    Ayako Kimura, Katsuhiko Yoshizawa, Tomo Sasaki, Norihisa Uehara, Yuichi Kinoshita, Hisanori Miki, Takashi Yuri, Takashi Uchida, Airo Tsubura

    Experimental and Therapeutic Medicine   4 ( 1 )   15 - 20   2012.7

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    DOI: 10.3892/etm.2012.559

  • Spontaneously occurring intracranial lipomatous hamartoma in a young BALB/c mouse and a literature review Reviewed

    Tomo Sasaki, Katsuhiko Yoshizawa, Yuichi Kinoshita, Hisanori Miki, Ayako Kimura, Takashi Yuri, Norihisa Uehara, Airo Tsubura

    Journal of Toxicologic Pathology   25 ( 2 )   179 - 182   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1293/tox.25.179

  • N-ethyl-N-nitrosourea induces retinal photoreceptor damage in adult rats Reviewed

    Katsuhiko Yoshizawa, Tomo Sasaki, Norihisa Uehara, Maki Kuro, Ayako Kimura, Yuichi Kinoshita, Hisanori Miki, Takashi Yuri, Airo Tsubura

    Journal of Toxicologic Pathology   25 ( 1 )   27 - 35   2012.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1293/tox.25.27

  • Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice Reviewed

    Sayaka Kanematsu, Katsuhiko Yoshizawa, Norihisa Uehara, Hisanori Miki, Tomo Sasaki, Maki Kuro, Yen Chang Lai, Ayako Kimura, Takashi Yuri, Airo Tsubura

    Oncology Reports   26 ( 3 )   603 - 608   2011.9

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    DOI: 10.3892/or.2011.1311

  • Calpain inhibition restores basal autophagy and suppresses MNU-induced photoreceptor cell death in mice Reviewed

    Maki Kuro, Katsuhiko Yoshizawa, Norihisa Uehara, Hisanori Miki, Kanji Takahashi, Airo Tsubura

    In Vivo   25 ( 4 )   617 - 623   2011.7

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  • Corneal damage induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea Reviewed

    Katsuhiko Yoshizawa, Tomo Sasaki, Maki Kuro, Hisanori Miki, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Airo Tsubura

    In Vivo   25 ( 4 )   609 - 615   2011.7

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  • Retinal degeneration induced in adult mice by a single intraperitoneal injection of N-Ethyl-N-nitrosourea Reviewed

    Katsuhiko Yoshizawa, Maki Kuro-Kuwata, Tomo Sasaki, Yen Chang Clark Lai, Sayaka Kanematsu, Hisanori Miki, Ayako Kimura-Kawanaka, Norihisa Uehara, Takashi Yuri, Airo Tsubura

    Toxicologic Pathology   39 ( 4 )   606 - 613   2011.6

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    DOI: 10.1177/0192623311402221

  • Anticancer effects of garlic and garlic-derived compounds for breast cancer control Reviewed

    Airo Tsubura, Yen Chang Lai, Maki Kuwata, Norihisa Uehara, Katsuhiko Yoshizawa

    Anti-Cancer Agents in Medicinal Chemistry   11 ( 3 )   249 - 253   2011.3

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  • Animal models of N-methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials Reviewed

    Airo Tsubura, Yen Chang Lai, Hisanori Miki, Tomo Sasaki, Norihisa Uehara, Takashi Yuri, Katsuhiko Yoshizawa

    In Vivo   25 ( 1 )   11 - 22   2011.1

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  • Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese macaque (Macaca fuscata). Reviewed

    Katsuhiko Yoshizawa, Kazuko Nakao, Mayu Habiro, Kazuko Hayashi, Maki Kuwata, Norihisa Uehara, Takashi Yuri, Kae Nakamura, Airo Tsubura

    Toxicologic Pathology   38 ( 7 )   1058 - 1063   2010.12

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    DOI: 10.1177/0192623310382561

  • Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials Reviewed

    A. Tsubura, K. Yoshizawa, M. Kuwata, Norihisa Uehara

    Histology and Histopathology   25 ( 7 )   933 - 944   2010.7

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  • N-methyl-N-nitrosourea-induced retinal degeneration in mice is independent of the p53 gene. Reviewed

    Katsuhiko Yoshizawa, Maki Kuwata, Ayako Kawanaka, Norihisa Uehara, Takashi Yuri, Airo Tsubura

    Molecular Vision   15   2919 - 2925   2009.12

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  • Biphasic effect of short-term pregnancy hormone treatment on N-methyl-N-nitrosourea-induced mammary carcinogenesis in young and old rats Reviewed

    Yen Chang Lai, Takashi Yuri, Norihisa Uehara, Yoichiro Matsuoka, Sayaka Kanematsu, Airo Tsubura

    Molecular Medicine Reports   2 ( 2 )   213 - 220   2009.3

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    DOI: 10.3892/mmr-00000086

  • Role of fatty acids in malignancy and visual impairment Epidemiological evidence and experimental studies Reviewed

    Airo Tsubura, T. Yuri, K. Yoshizawa, Norihisa Uehara, H. Takada

    Histology and Histopathology   24 ( 2 )   223 - 234   2009.2

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  • Estrogen and progesterone treatment mimicking pregnancy for protection from breast cancer Reviewed

    Airo Tsubura, Norihisa Uehara, Yoichiro Matsuoka, Katsuhiko Yoshizawa, Takashi Yuri

    In Vivo   22 ( 2 )   191 - 202   2008.3

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  • Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis Reviewed

    Yoichiro Matsuoka, Katsumi Fukamachi, Norihisa Uehara, Hiroyuki Tsuda, Airo Tsubura

    Cancer Science   99 ( 2 )   309 - 315   2008.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1349-7006.2007.00689.x

  • hnRNP U interacts with the c-Myc-Max complex on the E-box promoter region inducing the ornithine decarboxylase gene Reviewed

    Yoichiro Matsuoka, Norihisa Uehara, Airo Tsubura

    Oncology Reports   22 ( 2 )   249 - 255   2008.2

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    DOI: 10.3892/or_00000431

  • Effects of prepubertal indole-3-carbinol treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Sprague-Dawley rats Reviewed

    Naoto Shimano, Norihisa Uehara, Yasuhiko Kiyozuka, Nobuaki Shikata, Airo Tsubura

    In Vivo   21 ( 6 )   983 - 988   2007.11

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  • PARP inhibitors accelerate N-methyl-N-nitrosourea-induced cataractogenesis in Sprague-Dawley rats Reviewed

    Katsuaki Miki, Katsuhiko Yoshizawa, Norihisa Uehara, Takashi Yuri, Yoichiro Matsuoka, Airo Tsubura

    In Vivo   21 ( 5 )   739 - 744   2007.9

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  • N-methyl-N-nitrosourea-induced mammary carcinogenesis is promoted by short-term treatment with estrogen and progesterone mimicking pregnancy in aged female Lewis rats Reviewed

    Reiko Tsukamoto, Takako Mikami, Katsuaki Miki, Norihisa Uehara, Takashi Yuri, Yoichiro Matsuoka, Kazuichi Okazaki, Airo Tsubura

    Oncology Reports   18 ( 2 )   337 - 342   2007.8

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  • TAK1 represses transcription of the human telomerase reverse transcriptase gene Reviewed

    T. Fujiki, T. Miura, M. Maura, H. Shiraishi, S. Nishimura, Y. Imada, Norihisa Uehara, Kosuke Tashiro, S. Shirahata, Yoshinori Katakura

    Oncogene   26 ( 36 )   5258 - 5266   2007.8

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    DOI: 10.1038/sj.onc.1210331

  • Multistep mouse mammary tumorigenesis through preneoplasia to neoplasia and acquisition of metastatic potential Reviewed

    Airo Tsubura, Katsuhiko Yoshizawa, Norihisa Uehara, Takashi Yuri, Yoichiro Matsuoka

    Medical Molecular Morphology   40 ( 1 )   9 - 17   2007.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00795-006-0351-6

  • Poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide rescues N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in Sprague-Dawley rats through preservation of nuclear factor-κB activity Reviewed

    84 ( 2 )   285 - 292   2007.2

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    DOI: 10.1016/j.exer.2006.09.023

  • Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells Reviewed

    Takashi Yuri, Reiko Tsukamoto, Katsuaki Miki, Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura

    Oncology Reports   16 ( 6 )   1307 - 1312   2006.12

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  • Effects of different durations of estrogen and progesterone treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats Reviewed

    Takashi Yuri, Reiko Tsukamoto, Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura

    In Vivo   20 ( 6 B )   829 - 836   2006.11

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  • Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions Reviewed

    19 ( 6 )   959 - 964   2005.11

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  • Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress Reviewed

    Yoshinori Katakura, Kaichi Yoshizaki, Tomoharu Yasuda, Takahiro Tsunematsu, Norihisa Uehara, Takumi Miura, Tsukasa Fujiki, Sanetaka Shirahata

    Biochemical and Biophysical Research Communications   334 ( 2 )   450 - 459   2005.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2005.06.109

  • Effects of prepubertal exposure to xenoestrogen on development of estrogen target organs in female CD-1 mice Reviewed

    Yasuyoshi Nikaido, Naoyuki Danbara, Miki Tsujita-Kyutoku, Takashi Yuri, Norihisa Uehara, Airo Tsubura

    In Vivo   19 ( 3 )   487 - 494   2005.5

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  • Enterolactone induces apoptosis and inhibits growth of colo 201 human colon cancer cells both in vitro and in vivo Reviewed

    Naoyuki Danbara, Takashi Yuri, Miki Tsujita-Kyutoku, Reiko Tsukamoto, Norihisa Uehara, Airo Tsubura

    Anticancer Research   25 ( 3 B )   2269 - 2276   2005.5

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  • Dietary factors modifying breast cancer risk and relation to time of intake Reviewed

    Airo Tsubura, Norihisa Uehara, Yasuhiko Kiyozuka, Nobuaki Shikata

    Journal of Mammary Gland Biology and Neoplasia   10 ( 1 )   87 - 100   2005.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10911-005-2543-4

  • Dietary effects of conjugated docosahexaenoic acid on N-methyl-N- nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats Reviewed

    Naoyuki Danbara, Norihisa Uehara, Nobuaki Shikata, Hideho Takada, Takahiko Hada, Airo Tsubura

    Oncology Reports   12 ( 5 )   1079 - 1085   2004.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Effects of prepubertal zeranol exposure on estrogen target organs and N-methyl-N-nitrosourea-induced mammary tumorigenesis in female Sprague-Dawley rats Reviewed

    Takashi Yuri, Yasuyoshi Nikaido, Naoto Shimano, Norihisa Uehara, Nobuaki Shikata, Airo Tsubura

    In Vivo   18 ( 6 )   755 - 762   2004.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring Reviewed

    Yasuyoshi Nikaido, Katsuhiko Yoshizawa, Naoyuki Danbara, Miki Tsujita-Kyutoku, Takashi Yuri, Norihisa Uehara, Airo Tsubura

    Reproductive Toxicology   18 ( 6 )   803 - 811   2004.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.reprotox.2004.05.002

  • Conjugated docosahexaenoic acid suppresses KPL-1 human breast cancer cell growth in vitro and in vivo potential mechanisms of action. Reviewed

    Miki Tsujita-Kyutoku, Takashi Yuri, Naoyuki Danbara, Hideto Senzaki, Yasuhiko Kiyozuka, Norihisa Uehara, Hideho Takada, Takahiko Hada, Teruo Miyazawa, Yutaka Ogawa, Airo Tsubura

    Breast Cancer Research   6 ( 4 )   2004.4

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  • Neural stem cells lose telomerase activity upon differentiating into astrocytes Reviewed

    Takumi Miura, Yoshinori Katakura, Katsuhiko Yamamoto, Norihisa Uehara, Toshie Tsuchiya, Eun Ho Kim, Sanetaka Shirahata

    Cytotechnology   36 ( 1-3 )   137 - 144   2001.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1023/A:1014016315003

  • Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma Reviewed

    Yoshinori Katakura, Katsuhiko Yamamoto, Osamu Miyake, Tomoharu Yasuda, Norihisa Uehara, Eriko Nakata, Seiji Kawamoto, Sanetaka Shirahata

    Biochemical and Biophysical Research Communications   237 ( 2 )   313 - 317   1997.8

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    DOI: 10.1006/bbrc.1997.7104

▼display all

Books

  • 病気の分子形態学

    上原 範久( Role: Joint author)

    学際企画  2011.9 

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    Responsible for pages:290-292   Language:Japanese   Book type:Scholarly book

Presentations

  • 骨転移癌細胞—破骨細胞間コミニュケーションツールとしてのエクソソームの役割 Invited

    上原 範久, 久本 由香里, 三上剛和, 山座 孝義

    第66回 歯科基礎医学会  2024.11  歯科基礎医学会

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    Event date: 2024.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:長崎   Country:Japan  

  • 骨転移性乳癌細胞由来細胞外小胞に内包されるmiR-92a-3pは成熟破骨細胞の生存を促進する

    上原 範久,久本 由香里,三上 剛和, 園田 聡一朗, 山座 孝義, 久木田敏夫

    第82回日本癌学会学術総会  2023.9 

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    Event date: 2023.9

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • Breast cancer cell-derived extracellular vesicle-mediating transfer of miRNAs regulates osteoclast function Invited

    Norihisa Uehara, Yukari Kyumoto, Akiko Kukita, Toshio Kukita

    Cutting Edge of Bone and Mineral Research  2019.12 

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    Event date: 2019.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 骨転移性乳癌細胞由来細胞外小胞に内包されるmicroRNAと破骨細胞間コミュニケーション

    上原 範久、久本 由香里、久木田 明子、久木田 敏夫

    第37回骨代謝学会  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • 骨転移性乳癌細胞由来細胞外小胞を介した破骨細胞制御

    上原 範久、久本由香里、久木田明子、山座孝義、久木田敏夫

    日本解剖学会第74回九州支部学術集会  2018.10 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:佐賀大学   Country:Japan  

  • 骨転移癌細胞—破骨細胞間コミニュケーションツールとしてのエクソソームの役割 Invited

    上原 範久, 久本 由香里, 久木田 明子, 久木田 敏夫

    日本解剖学会  2018.3 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • ラミニン-332は骨芽細胞で発現し、破骨細胞形成を負に制御する

    上原 範久, 久木田 明子, 久本 由香里, 保田 尚孝, 久木田 敏夫

    歯科基礎医学会  2017.9 

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    Event date: 2017.9

    Language:Japanese  

    Venue:松本   Country:Japan  

    researchmap

  • Extracellular vesicles from bone metastatic mammary tumor cells facilitate osteoclast formation and bone resorption in vitro.

    2017.7 

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    Event date: 2017.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • ラミニン-332の骨芽細胞での発現と破骨細胞分化制御

    上原 範久, 久木田 明子, 久本 由香里, 保田 尚孝, 久木田 敏夫

    日本解剖学会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:長崎大学   Country:Japan  

  • 骨転移性乳癌細胞由来エクソソームを介した破骨細胞分化制御メカニズム

    上原 範久, 久本 由香里, 久木田 明子, 久木田 敏夫

    日本分子生物学会  2016.12 

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    Event date: 2016.11 - 2016.12

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • Metastatic mammary tumor-derived exosomes promote osteoclast differentiation

    2016.7 

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    Event date: 2016.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • ニコチンアミドはヒストン脱アセチル化酵素阻害剤vorinostat誘導細胞死を増強する

    上原 範久, 義澤 克彦

    日本分子生物学会  2014.11 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:パシフィコ横浜   Country:Japan  

  • Inhibition of in vitro cell motility and invasive potential by microRNA-148a in human breast cancer cells

    2013.10 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 分泌型miRNAを介した骨転移性癌細胞-破骨細胞間コミュニケーション Invited

    上原 範久, 久本 由香里, 久木田 明子, 久木田 敏夫

    日本解剖学会  2016.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:ビッグパレット福島   Country:Japan  

  • Molecular cloning and characterization of specific genes possibly involved in cellular senescence International conference

    N. Uehara, Y. Katakura, K. Teruya, S. Shirahata

    The Joint Meeting of the Japanese Association for Animal Cell Technology and the Europian Society for Animal Cell Technology  1998.11 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Subtractive screening of genes involved in cellular senescence International conference

    N. Uehara, Y. Katakura, T. Miura, S. Shirahata

    World Congress on In Vitro Biology  2000.6 

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    Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • Involvement of mitochondrial DNA in cellular senescence International conference

    N. Uehara, Y. Katakura, T. Miura, S. Shirahata

    Annual and International Meeting of the Japanese Association for Animal Cell Technology  2001.11 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Involvement of Id genes in mammary development and its implications to carcinogenesis. International conference

    N. Uehara, YC. Chou, J. Galvez, R. Cardiff, G. Shyamala

    American association of cancer research annual meeting  2002.4 

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    Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • 経産後乳腺における発癌抑制能の獲得とその機構解明に向けた網羅的遺伝子発現解析

    上原範久,清塚康彦,四方伸明,螺良愛郎

    日本癌学会  2004.9 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • ニコチンアミドによるpoly (ADP-ribose) polymerase (PARP)-1を介したラット視細胞アポトーシスの抑制機序

    上原範久,清塚康彦,四方伸明,螺良愛郎

    日本病理学会  2004.4 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:札幌   Country:Japan  

  • Nicotinamideによるpoly(ADP-ribose)polymerase-1を介したラット視細胞アポトーシスの抑制

    上原範久,清塚康彦,四方伸明,螺良愛郎

    日本組織細胞化学会  2004.10 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:鹿児島   Country:Japan  

  • 経産後乳腺における発癌剤刺激応答と発癌抑制機構の解析

    上原範久,清塚康彦,松岡洋一郎,四方伸明,螺良愛郎

    日本病理学会  2005.4 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 経産後乳腺における発癌剤刺激応答と発癌抑制機構解明に向けた網羅的遺伝子発現解析

    上原範久、清塚康彦、四方伸明、螺良愛郎

    日本分子生物学会  2005.12 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 経産乳腺における発癌抑制機序解明に向けた特異的制御遺伝子の単離とその機能解析

    上原範久, 清塚康彦, 松岡洋一郎, 螺良愛郎

    日本病理学会  2006.4 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 経産乳腺特異的遺伝子の単離とヒト乳癌細胞株増殖に及ぼす影響

    上原範久, 清塚康彦, 松岡洋一郎, 螺良愛郎

    日本癌学会  2006.9 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Alterations in gene expression before and after carcinogenic stimuli on parous mammary glands in Lewis rats International conference

    A. Tsubura, N. Uehara, Y. Kiyozuka, T. Yuri, Y. Matsuoka

    International association of breast cancer research annual meeting  2006.9 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Canada  

  • Mesothelin過剰発現乳癌細胞株における足場非依存的増殖促進とanoikis抑制機構の解明

    上原範久、松岡洋一郎、螺良愛郎

    日本病理学会  2007.3 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • Mesothelin過剰発現乳癌細胞株における足場非依存的増殖促進とERKシグナル経路を介したanoikis抑制機序

    上原範久、松岡洋一郎、螺良愛郎

    乳癌基礎研究会  2007.7 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • Mesothelin promotes anchorage independent growth and prevents anoikis via ERK signaling pathway in human breast cancer cells

    N. Uehara, Y. Matsuoka, A. Tsubura

    2007.10 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ヒストン脱アセチル化酵素阻害剤の乳癌細胞増殖抑制におけるp38MAPK活性化の関与

    上原範久、兼松清果、松岡洋一郎、螺良愛郎

    日本分子生物学会  2007.12 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • ヒストン脱アセチル化酵素阻害剤の乳癌細胞増殖抑制機序とp38MAPK活性化の関与

    上原範久、兼松清果、松岡洋一郎、螺良愛郎

    日本病理学会  2008.5 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:金沢   Country:Japan  

  • Molecular mechanisms of suberoylanilide hydroxamic acid-induced G2/M arrest in human breast cancer (MDA-MB-231) cells

    2008.10 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ヒストン脱アセチル化酵素阻害剤によるSkp2, Cks1発現制御とp27の安定化

    上原範久、兼松清果、松岡洋一郎、螺良愛郎

    日本分子生物学会  2008.12 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • ヒストン脱アセチル化酵素阻害剤によるMAPキナーセシグナルを介した乳癌細胞死誘導機序

    上原範久、兼松清果、松岡洋一郎、螺良愛郎

    日本病理学会  2009.5 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 妊娠を契機とした乳腺発癌耐性獲得の分子基盤

    上原範久、螺良愛郎

    日本臨床分子形態学会  2009.9 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • Role of p38MAPK in a cell-death pathway triggered by suberoylanilide hydroxamic acid (SAHA) in human breast cancer cells

    N. Uehara, Y. Matsuoka, A. Tsubura

    2009.10 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ヒストン脱アセチル化酵素阻害剤による乳癌細胞アポトーシス誘導 〜p38活性化シグナル経路の解析〜

    上原範久、兼松清果、三城弥範、義澤克彦、螺良愛郎

    日本病理学会  2010.4 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Role of p38MAPK in a cell-death pathway triggered by vorinostat in human breast cancer MDA-MB-231 cells

    N. Uehara, S. Kanematsu, H. Miki, K. Yoshizawa, A. Tsubura

    2010.7 

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    Country:Japan  

  • Vorinostat induces H2AX phosphorylation through p38 MAPK pathway in human breast cancer cells

    N. Uehara, Y. Matsuoka, A. Tsubura

    2010.9 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • HDAC阻害剤vorinostatのヒト乳癌細胞株に対するDNA損傷応答シグナルへの影響

    上原範久, 三城弥範, 義澤克彦, 螺良愛郎

    日本病理学会  2011.4 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • Vorinostat enhances protein stability of p27 through negative regulatin of Skp2 and Cks1 in human breast cancer cells

    N. Uehara, Yoshizawa, A. Tsubura

    2011.10 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Identification of tumor suppressive miRNAs induced by histone deacetlase inhibitor vorinostat in human breast cancver cells.

    N. Uehara, Yoshizawa, A. Tsubura

    2011.12 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Vorinostat誘導乳癌細胞増殖抑制におけるSkp2、Cks1発現抑制とp27、p21の安定化

    上原範久, 義澤克彦, 螺良愛郎

    日本病理学会  2012.4 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Vorinostat誘導乳癌細胞増殖抑制におけるmiR-148a発現とその役割

    上原範久

    日本がん分子標的治療学会  2012.6 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:北九州   Country:Japan  

  • MicroRNA-148a suppresses cell migration and invasion in human breast cancer cells: possible involvement of epithelial-mesenchimal transition pathway

    Norihisa Uehara*, Katsuhiko Yoshizawa, Ayako Kimura, Airo Tsubura

    2012.12 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 細胞外マトリックス分子ラミニン332による破骨細胞分化制御とJNKシグナルの関与

    上原 範久, 久木田 明子, 保田 尚孝, 久木田 敏夫

    日本骨代謝学会  2014.7 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • 細胞外マトリックス分子ラミニン332は破骨細胞形成を負に制御する

    上原 範久, 久木田 明子, 久本 由香里, 保田 尚孝, 久木田 敏夫

    歯科基礎医学会  2014.9 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • ラミニン-332によるRANK発現調節とマクロファージ-破骨細胞分化転換

    上原 範久, 久木田明子, 久本 由香里, 保田尚孝, 久木田 敏夫

    日本骨代謝学会学術集会  2015.7 

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    Language:Japanese  

    Venue:京王プラザホテル   Country:Japan  

  • 細胞外マトリックス分子ラミニン332の破骨細胞形成抑制作用

    上原 範久, 久木田 明子, 久本 由香里, 保田 尚孝, 久木田 敏夫

    西日本骨・関節関連疾患懇話会  2015.7 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 骨芽細胞特異的な骨改造制膜表面分子の同定:アルカリ 微小環境による石灰化制御の可能性について

    日浦 秀暢、久本 由香里,顧 炯炎、張 旌旗、上原 範久、山座 孝義、久木田明子、高橋 一郎、久木田敏夫

    第39回日本骨代謝学会  2021.10 

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    Event date: 2021.10

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 骨吸収および炎症性骨破壊における破骨細胞形成と細胞膜ナノチューブの関与

    張 旌旗、顧 炯炎、久本 由香里、久木田 明子、張 暁旭、上原 範久、日浦 秀暢、山座 孝義、久木田 敏夫

    第62回歯科基礎医学会  2020.9 

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    Event date: 2020.9 - 2020.10

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 胆道閉鎖症患児由来乳歯幹細胞の細胞移植治療効果を制御する機序の解析

    園田 聡一朗、村田 早羅、加藤 大樹、久本 由香里、上原 範久、久木田 敏夫、山座 孝義

    第62回歯科基礎医学会  2020.9 

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    Event date: 2020.9 - 2020.10

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 骨芽細胞特異的な骨改造制御膜表面分子の同定と機能解析

    日浦 秀暢、久本 由香里、上原 範久、張 旌旗、顧 炯炎、山座 孝義、久木田 明子、高橋 一郎、久木田 敏夫

    第62回歯科基礎医学会  2020.9 

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    Event date: 2020.9 - 2020.10

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 免疫調節膜表面分子Tim-3の破骨細胞での発現と炎症性骨破壊制御

    森山 加奈子, 久木田 明子, 上原 範久, 久本 由香里, 張 旌旗, 髙橋 一郎, 久木田 敏夫

    歯科基礎医学会  2014.9 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場   Country:Japan  

  • Id-3 is a potential mediator of progesterone receptor dependent proliferation and apoptosis in mammary glands of PR-A transgenic mice. International conference

    YC. Chou, N. Uehara, G. Shyamala

    Endocrine society annual meeting  2002.6 

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    Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • 炎症抑制性因子ガレクチン 9 の膜表面受容体 Tim3 を介した破骨細胞形成制御

    森山 加奈子, 久木田 明子, 上原 範久, 張 旌旗, 高橋 一郎, 久木田 敏夫

    歯科基礎医学会  2013.9 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:岡山   Country:Japan  

  • 膜ナノチューブを介する破骨前駆細胞間融合の走査電顕的解析

    張 旌旗、高橋 良、久木田 明子、成松 加奈子、上原 範久、山座 孝義、城戸 瑞穂、久木田 敏夫

    歯科基礎医学会  2013.9 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:岡山   Country:Japan  

  • 炎症抑制因子ガレクチン9の膜表面受容体Tim-3を介した破骨細胞形成制御

    森山 加奈子, 久木田 明子, 上原 範久, 張 旌旗, 高橋 一郎, 久木田 敏夫

    西日本骨・関節関連疾患懇話会  2014.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 免疫制御膜表面分子Tim-3を介する炎症性骨破壊制御

    森山 加奈子, 久木田 明子, 上原 範久, 久本 由香里, 高橋 一郎, 久木田 敏夫

    日本骨代謝学会  2014.7 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • 骨転移性乳癌細胞由来細胞外小胞に内包されるmiR-92a-3pは成熟破骨細胞の生存を促進する(Bone metastatic mammary tumor cell-derived extracellular vesicles promote mature osteoclast longevity)

    上原 範久, 久本 由香里, 三上 剛和, 園田 聡一朗, 山座 孝義, 久木田 敏夫

    日本癌学会総会記事  2023.9  (一社)日本癌学会

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    Language:English  

  • 胸腺間葉系ストロマ細胞による内在性制御性T細胞の産生メカニズムの解明

    園田 聡一朗, 久本 由香里, 加藤 大樹, 上原 範久, 山座 孝義

    Journal of Oral Biosciences Supplement  2023.9  (一社)歯科基礎医学会

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  • 根尖歯乳頭組織由来幹細胞に発現する転写因子PITX2の機能解析

    久本 由香里, 園田 聡一朗, 加藤 大樹, 上原 範久, 山座 孝義

    Journal of Oral Biosciences Supplement  2023.9  (一社)歯科基礎医学会

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    Language:Japanese  

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MISC

  • Anticancer effects of garlic and garlic-derived compounds for breast cancer control.

    A. Tsubura, Y.C. Lai, M. Kuwata, N. Uehara, K. Yoshizawa

    Anticancer Agents Med Chem   2011.3

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  • Animal Models of N-Methyl-N-nitrosourea-induced Mammary Cancer and Retinal Degeneration with Special Emphasis on Therapeutic Trials.

    A. Tsubura, Y.C. Lai, H. Miki, T. Sasaki, N. Uehara, T. Yuri, K. Yoshizawa

    In Vivo   2011.1

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  • Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials.

    A. Tsubura, K. Yoshizawa, M. Kuwata, N. Uehara

    Histol Histopathol   2010.7

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  • Role of fatty acids in malignancy and visual impairment: epidemiological evidence and experimental studies.

    A. Tsubura, T. Yuri, K. Yoshizawa, N. Uehara, H. Takada

    Histol Histopathol   2009.2

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  • Estrogen and progesterone treatment mimicking pregnancy for protection from breast cancer.

    A. Tsubura, N. Uehara, Y. Matsuoka, K. Yoshizawa, T. Yuri

    In Vivo   2008.3

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  • Multistep mouse mammary tumorigenesis through pre-neoplasia to neoplasia and acquisition of metastatic potential.

    A. Tsubura, K. Yoshizawa, N. Uehara, T. Yuri, Y. Matsuoka

    Med Mol Morphol   2007.3

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Dietary factors modifying breast cancer risk and relation to time of intake.

    A. Tsubura, N. Uehara, Y. Kiyozuka, N. Shikata

    J Mammary Gland Biol Neoplasia   2005.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Professional Memberships

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Committee Memberships

  • Organizer   Domestic

    2013.7 - 2015.7   

  • Organizer   Domestic

    2011.7 - 2016.7   

  • 第41回日本臨床分子形態学会総会・学術集会   実行委員   Domestic

    2009.9   

Academic Activities

  • シンポジスト

    第66回 歯科基礎医学会シンポジウム  2024.11

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    Type:Competition, symposium, etc. 

  • シンポジスト International contribution

    2019.12

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    Type:Competition, symposium, etc. 

  • シンポジウムオーガナイザー

    日本解剖学会  ( 東京 ) 2018.3

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    Type:Competition, symposium, etc. 

  • シンポジスト

    日本解剖学会  ( 福島 ) 2016.3

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    Type:Competition, symposium, etc. 

  • シンポジスト

    日本臨床分子形態学会  ( 神戸国際会議場 ) 2009.9

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    Type:Competition, symposium, etc. 

  • Screening of academic papers International contribution

    Role(s): Peer review

    2024

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:22

  • Screening of academic papers International contribution

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:12

  • Screening of academic papers International contribution

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:19

  • Screening of academic papers International contribution

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • Screening of academic papers International contribution

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:14

  • Screening of academic papers International contribution

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:11

  • Screening of academic papers International contribution

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:13

  • Screening of academic papers International contribution

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:11

  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:15

  • 幹事

    老化研究会  ( 九州大学 大阪オフィス ) 2013.12

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  • 幹事

    老化研究会  ( 九州大学 ) 2012.12

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    Type:Competition, symposium, etc. 

  • 幹事

    老化研究会  ( 順天堂大学 ) 2011.9

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Research Projects

  • Mechanical stress response of senescent osteocytes: an intercellular communication between bone resident cells mediated by specific secreted factors.

    Grant number:22K09403  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

    CiNii Research

  • タンパク質分解酵素阻害因子(SLPI)によるがん病態の悪性化誘導機構の検討

    Grant number:18K07226  2018 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 骨細胞を基軸とした骨吸収トリガーエクソソームの探索と骨破壊制御への展開

    Grant number:18K09522  2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 分泌型miRNAを介した骨転移癌細胞-骨代謝細胞間コミュニケーションと骨破壊制御

    Grant number:15K11014  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • アラキドン酸によるMNU誘発網膜色素変性症動物モデルの病態制御とその分子機構

    Grant number:24592661  2012 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • HDAC・PARP制御を介した合成致死誘導の分子基盤と乳癌治療へのアプローチ

    Grant number:24591923  2012 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • HDAC制御を介した癌抑制における新規標的マイクロRNAの探索と治療への展開

    2011

    大阪コミュニティ財団 がん研究助成

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    Authorship:Principal investigator  Grant type:Contract research

  • MNU誘発網膜色素変性症動物モデルにおけるオートファジーの関与とその分子制御

    Grant number:22591954  2010 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • HDAC制御を介した癌抑制における新規標的マイクロRNAの探索と治療への展開

    Grant number:22791263  2010 - 2011

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • スルフォラファンのオートファジーを介する乳癌細胞死滅機構の同定と癌治療への応用

    Grant number:21591683  2009 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • アセチル化修飾による細胞周期制御の分子機構と乳癌抑制に向けた新規標的分子の探索

    Grant number:20790940  2008 - 2009

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • HDAC阻害剤によるSCFユビキチンリガーゼ複合体制御の分子基盤と乳癌治療への応用

    2008

    大阪対ガン協会

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    Authorship:Principal investigator  Grant type:Contract research

  • 未産・経産ラット乳腺のDNAメチル化状態の網羅的比較による乳癌予防

    Grant number:19591522  2007 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • アセチル化修飾を介したヒト乳癌細胞増殖抑制における細胞質分裂制御の役割

    2007

    大阪対ガン協会

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    Authorship:Principal investigator  Grant type:Contract research

  • 経産乳腺の発癌抵抗性獲得におけるエピジェネティクスと遺伝子発現制御機構の解明

    Grant number:18790947  2006 - 2007

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 経産後乳腺における発癌刺激応答と癌抑制機構の分子生物学的解明

    2006

    藤田記念医学研究研究振興基金

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    Authorship:Principal investigator  Grant type:Contract research

  • Mesothelinによる足場非依存的増殖促進とanoikis耐性獲得機構の解明

    2006

    大阪対ガン協会

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    Authorship:Principal investigator  Grant type:Contract research

  • 妊娠期ホルモン環境を模倣した乳癌予防プロトコールの確立とその分子基盤の解明

    Grant number:17591361  2005 - 2006

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 周生期Zeranol摂取による発育・発癌への影響

    Grant number:16510047  2004 - 2005

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 経産後乳腺における発癌抑制能の獲得とその機構解明に向けた分子生物学的アプローチ

    Grant number:16790766  2004 - 2005

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

▼display all

Class subject

  • 口腔組織学3

    2023.12 - 2024.2   Winter quarter

  • 口腔組織学2

    2023.10 - 2023.12   Fall quarter

  • 口腔組織学1

    2023.6 - 2023.8   Summer quarter

  • 分子口腔解剖学

    2023.4 - 2024.3   Full year

  • 口腔解剖学

    2023.4 - 2024.3   Full year

  • 解剖学

    2023.4 - 2024.3   Full year

  • 発生学

    2023.4 - 2023.6   Spring quarter

  • 口腔組織学3

    2022.12 - 2023.2   Winter quarter

  • 口腔組織学2

    2022.10 - 2022.12   Fall quarter

  • 口腔組織学1

    2022.6 - 2022.8   Summer quarter

  • 分子口腔解剖学

    2022.4 - 2023.3   Full year

  • 口腔解剖学

    2022.4 - 2023.3   Full year

  • 解剖学

    2022.4 - 2023.3   Full year

  • リサーチエクスポージャー

    2022.4 - 2022.6   Spring quarter

  • 発生学

    2022.4 - 2022.6   Spring quarter

  • 口腔組織学II

    2021.10 - 2022.3   Second semester

  • リサーチエクスポージャー

    2021.4 - 2022.3   Full year

  • 分子口腔解剖学演習

    2021.4 - 2022.3   Full year

  • 分子口腔解剖学

    2021.4 - 2022.3   Full year

  • 解剖学

    2021.4 - 2022.3   Full year

  • 口腔組織学I

    2021.4 - 2021.9   First semester

  • アーリーエクスポージャー

    2021.4 - 2021.6   Spring quarter

  • 口腔組織学II 実習

    2020.10 - 2021.3   Second semester

  • 分子口腔解剖学演習

    2020.4 - 2021.3   Full year

  • 分子口腔解剖学

    2020.4 - 2021.3   Full year

  • 解剖学

    2020.4 - 2020.9   First semester

  • 口腔組織学I

    2020.4 - 2020.9   First semester

  • 口腔組織学II 実習

    2019.10 - 2020.3   Second semester

  • 口腔組織学II

    2019.10 - 2020.3   Second semester

  • 分子口腔解剖学演習

    2019.4 - 2020.3   Full year

  • 分子口腔解剖学

    2019.4 - 2020.3   Full year

  • 硬組織研究法

    2019.4 - 2020.3   Full year

  • リサーチエクスポージャー

    2019.4 - 2020.3   Full year

  • 解剖学

    2019.4 - 2019.9   First semester

  • 口腔組織学I

    2019.4 - 2019.9   First semester

  • 口腔組織学II

    2018.10 - 2019.3   Second semester

  • 口腔組織学II 実習

    2018.10 - 2019.3   Second semester

  • リサーチエクスポージャー

    2018.4 - 2019.3   Full year

  • 分子口腔解剖学演習

    2018.4 - 2019.3   Full year

  • 分子口腔解剖学

    2018.4 - 2019.3   Full year

  • 硬組織研究法

    2018.4 - 2019.3   Full year

  • アーリーエクスポージャー

    2018.4 - 2018.9   First semester

  • 口腔組織学I

    2018.4 - 2018.9   First semester

  • 解剖学

    2018.4 - 2018.9   First semester

  • アーリーエクスポージャー

    2018.4 - 2018.9   First semester

  • 口腔組織学II

    2017.10 - 2018.3   Second semester

  • 口腔組織学II 実習

    2017.10 - 2018.3   Second semester

  • 分子口腔解剖学演習

    2017.4 - 2018.3   Full year

  • 硬組織研究法

    2017.4 - 2018.3   Full year

  • 分子口腔解剖学

    2017.4 - 2018.3   Full year

  • 口腔組織学I

    2017.4 - 2017.9   First semester

  • 解剖学

    2017.4 - 2017.9   First semester

  • 口腔組織学II 実習

    2016.10 - 2017.3   Second semester

  • 口腔組織学II (舌・味蕾)

    2016.10 - 2017.3   Second semester

  • 硬組織研究法

    2016.4 - 2017.3   Full year

  • 分子口腔解剖学演習

    2016.4 - 2017.3   Full year

  • 分子口腔解剖学

    2016.4 - 2017.3   Full year

  • 解剖学

    2016.4 - 2016.9   First semester

  • 発生学(骨格系)

    2016.4 - 2016.9   First semester

  • 口腔組織学I

    2016.4 - 2016.9   First semester

  • 口腔組織学I (舌・味蕾)

    2015.10 - 2016.3   Second semester

  • 口腔組織学II 実習

    2015.10 - 2016.3   Second semester

  • 分子口腔解剖学演習

    2015.4 - 2016.3   Full year

  • 硬組織研究法

    2015.4 - 2016.3   Full year

  • 分子口腔解剖学

    2015.4 - 2016.3   Full year

  • 口腔組織学I

    2015.4 - 2015.9   First semester

  • 解剖学

    2015.4 - 2015.9   First semester

  • 発生学(骨格系)

    2015.4 - 2015.9   First semester

  • 硬組織研究法

    2014.4 - 2015.3   Full year

  • 解剖学

    2014.4 - 2015.3   Full year

  • 分子口腔解剖学演習

    2014.4 - 2015.3   Full year

  • 分子口腔解剖学

    2014.4 - 2015.3   Full year

  • 口腔組織学II

    2014.4 - 2014.9   First semester

  • 口腔細胞生物学

    2014.4 - 2014.9   First semester

  • 硬組織研究法

    2013.4 - 2014.3   Full year

  • 解剖学

    2013.4 - 2014.3   Full year

  • 分子口腔解剖学演習

    2013.4 - 2014.3   Full year

  • 分子口腔解剖学

    2013.4 - 2014.3   Full year

  • 口腔組織学II

    2013.4 - 2013.9   First semester

  • アーリーエクスポージャII

    2013.4 - 2013.9   First semester

  • 口腔細胞生物学

    2013.4 - 2013.9   First semester

▼display all

FD Participation

  • 2024.3   Role:Participation   Title:有体物管理センターの業務および成果有体物収入の配分率の変更について

    Organizer:University-wide

  • 2022.12   Role:Participation   Title:〈オンライン〉リベラルサイエンス教育開発FD 「環境省『ぐぐるプロジェクト』とのコラボレーションでつくる学際的な授業」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.7   Role:Participation   Title:廃棄物の分別と正しい廃棄の仕方について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.3   Role:Participation   Title:学習支援システム(M2B)講習会(オンライン開催)◇初級編・中・上級編◇13:00~15:00

    Organizer:University-wide

  • 2021.3   Role:Participation   Title:M2B(みつば)講習会

    Organizer:University-wide

  • 2020.6   Role:Participation   Title:電子ジャーナルをめぐる現状と今後に向けた対応について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.9   Role:Participation   Title:科研費申請のススメ

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.8   Role:Participation   Title:歯学研究院FD 「SciVal及びPureに関する説明会」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.7   Role:Participation   Title:平成33年度入学者選抜改革【九州大学新入試QUBE】

    Organizer:University-wide

  • 2017.10   Role:Participation   Title:平成29年度 病院地区4部局合同男女共同参画FD 「無意識のバイアスからの開放:ダイバーシティのススメ」

    Organizer:University-wide

  • 2016.12   Role:Participation   Title:歯学教育の現状と課題

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.2   Role:Participation   Title:ルーブリック作成に関するFD研修会

    Organizer:Undergraduate school department

  • 2014.9   Role:Participation   Title:科研費獲得のポイント

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.8   Role:Participation   Title:新GPA制度実施のためのFD

    Organizer:University-wide

  • 2013.4   Role:Participation   Title:新任教員の研修

    Organizer:University-wide

▼display all

Social Activities

  • サマースクール2024/高校生、受験生を対象とした九州大学歯学部の公開講座

    Role(s): Lecturer

    九州大学歯学部  九州大学  2024.8

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 九州大学テクノロジーフォーラム 2014/産学官連携を目的とした研究シーズ発表

    九州大学  東京国際フォーラム  2014.12

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • サマースクール2014/高校生、受験生を対象とした九州大学歯学部の公開講座

    九州大学歯学部  九州大学  2014.8

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

Travel Abroad

  • 2001.4 - 2003.4

    Staying countory name 1:United States   Staying institution name 1:Lawrence Berkeley National Laboratory, Life Sciences Division