Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells Reviewed

Norihisa Uehara, Sayaka Kanematsu, Hisanori Miki, Katsuhiko Yoshizawa, Airo Tsubura

Cancer Letters   315 ( 2 )   112 - 121   2012.2

ヒストン脱アセチル化酵素阻害剤vorinostatによるp38MAPキナーゼシグナルを介した乳癌細胞死誘導機序 Reviewed

上原範久, 兼松清果, 三城弥範, 義澤克彦, 螺良愛郎

乳癌基礎研究   20   17 - 21   2011.1

Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells Reviewed

Sayaka Kanematsu, Norihisa Uehara, Hisanori Miki, Katsuhiko Yoshizawa, Ayako Kawanaka, Takashi Yuri, Airo Tsubura

Anticancer Research   30 ( 9 )   3381 - 3390   2010.9

Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells Reviewed

Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura

Molecular Cancer Research   6 ( 2 )   186 - 193   2008.2

Mesothelin過剰発現乳癌細胞株における足場非依存的増殖促進とERKシグナル経路を介したアノイキス抑制機序 Reviewed

上原範久、松岡洋一郎、螺良愛郎

乳癌基礎研究   17   21 - 25   2008.1

Parous mammary glands exhibit distinct alterations in gene expression and proliferation responsiveness to carcinogenic stimuli in Lewis rats Reviewed

Norihisa Uehara, Akira Unami, Yasuhiko Kiyozuka, Nobuaki Shikata, Yuji Oishi, Airo Tsubura

Oncology Reports   15 ( 4 )   903 - 911   2006.4

Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADP-ribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition Reviewed

Norihisa Uehara, Katsuaki Miki, Reiko Tsukamoto, Yoichiro Matsuoka, Airo Tsubura

Experimental Eye Research   82 ( 3 )   488 - 495   2006.3

Id-1 is not expressed in the luminal epithelial cells of mammary glands Reviewed

Norihisa Uehara, Yu Chien Chou, Jose J. Galvez, Paola de-Candia, Robert D. Cardiff, Robert Benezra, Gopalan Shyamala

Breast Cancer Research   5 ( 2 )   2003.4

Mammary epithelial cells of PR-A transgenic mice exhibit distinct alterations in gene expression and growth potential associated with transformation Reviewed

Yu Chien Chou, Norihisa Uehara, Jason R. Lowry, G. Shyamala

Carcinogenesis   24 ( 3 )   403 - 409   2003.3

Subtractive screening of genes involved in cellular senescence Reviewed

Norihisa Uehara, Yoshinori Katakura, Takumi Miura, Sanetaka Shirahata

Cytotechnology   35 ( 1 )   35 - 42   2001.1

Identification of specific genes involved in cellular senescence by using human lung adenocarcinoma derived cells Invited Reviewed International journal

Uehara, N. Katakura, Y. Nishimoto, S. Teruya, K. Shirahata, S.

Animal Cell Technology: Basic & Applied Aspects   Vol 10   375 - 379   1999.1

Molecular cloning and characterization of specific genes involved in cellular senescence Invited Reviewed International journal

Uehara, N. Katakura, Y. Miura, T. Shirahata, S.

Animal Cell Technology: Challenges for the 21st Century   1999.1

Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease Reviewed International journal

Mhd Fouad Zakaria, Soichiro Sonoda, Hiroki Kato, Lan Ma, Norihisa Uehara, Yukari Kyumoto-Nakamura, M Majd Sharifa, Liting Yu, Lisha Dai, Erika Yamauchi-Tomoda, Reona Aijima, Haruyoshi Yamaza, Fusanori Nishimura, Takayoshi Yamaza

Scientific Reports   6719 ( 14 )   2024.3

Modulation of Osteoclastogenesis through Adrenomedullin Receptors on Osteoclast Precursors: Initiation of Differentiation by Asymmetric Cell Division Reviewed International journal

Toshio Kukita, Hidenobu Hiura, Jiong-Yan Gu, Yukari Kyumoto-Nakamura, Jing-Qi Zhang, Norihisa Uehara, Sara Murata, Soichiro Sonoda, Takayoshi Yamaza, Ichiro Takahashi, and Akiko Kukita

Laboratory Investigation   101 ( 11 )   1449 - 1457   2021.9

Exosomes Derived from Fisetin-treated Keratinocytes Mediate Hair Growth Promotion Invited Reviewed International journal

Mizuki Ogawa, Miyako Udono, Kiichiro Teruya, Norihisa Uehara, Yoshinori Katakura

Nutrients   13 ( 6 )   2087   2021.6

Targeting of Deciduous Tooth Pulp Stem Cell-Derived Extracellular Vesicles on Telomerase-Mediated Stem Cell Niche and Immune Regulation in Systemic Lupus Erythematosus Invited Reviewed International journal

Soichiro Sonoda, Sara Murata, Hiroki Kato, Fouad Zakaria, Yukari Kyumoto-Nakamura, Norihisa Uehara, Haruyoshi Yamaza, Toshio Kukita, Takayoshi Yamaza

The Journal of Immunology   206 ( 12 )   3053 - 3063   2021.4

In vitro and in vivo detection of tunneling nanotubes in normal and pathological osteoclastogenesis involving osteoclast fusion Invited Reviewed International journal

Jing-Qi Zhang, Akira Takahashi, Jiong-Yan Gu, Xiaoxu Zhang, Yukari Kyumoto-Nakamura, Akiko Kukita, Norihisa Uehara, Hidenobu Hiura, Takayoshi Yamaza, and Toshio Kukita

Laboratory Investigation   101 ( 12 )   1571 - 1584   2021.4

Fisetin Promotes Hair Growth by Augmenting TERT Expression Reviewed International journal

Chisato Kubo, Mizuki Ogawa, Norihisa Uehara, Yoshinori Katakura

Frontiers in Cell and Developmental Biology   8   2020.10

Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model Reviewed

Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita, Takayoshi Yamaza

Stem Cell Research and Therapy   11 ( 1 )   2020.7

Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model Invited Reviewed International journal

Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita, Takayoshi Yamaza

Stem Cell Research and Therapy   11 ( 1 )   296   2020.7

Osteoblast lineage-specific cell-surface antigen (A7) regulates osteoclast recruitment and calcification during bone remodeling Reviewed International journal

Badawy, T. Kyumoto-Nakamura, Y. Uehara, N. Zhang, J. Sonoda, S. Hiura, H. Yamaza, T. Kukita, A. Kukita, T.

Laboratory Investigation   99 ( 6 )   866 - 884   2019.6

Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla Reviewed

Yosuke Tanaka, Soichiro Sonoda, Haruyoshi Yamaza, Sara Murata, Kento Nishida, Yukari Kyumoto-Nakamura, Norihisa Uehara, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza

Journal of Endodontics   45 ( 5 )   591 - 598.e6   2019.5

Unique Osteoblast-Specific Cell-Surface Antigen Useful for Odontoblast Ontology and Dentin Regeneration Reviewed International journal

Badawy, T. Kyumoto-Nakamura, Y. Uehara, N. Zhang, J. Hiura, H. Sonoda, S. Yamaza, T. Kukita, A. Kukita, T.

Oral Health & Dental Science   2018.11

Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla Reviewed International journal

Tanaka, Y. Sonoda, S. Yamaza, H. Murata, S. Nishida, K. Hama, S. Kyumoto-Nakamura, Y. Uehara, N. Nonaka, K. Kukita, T. Yamaza, T.

Stem Cell Res Ther   9 ( 1 )   334   2018.11

Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells Reviewed

Soichiro Sonoda, Yu Feng Mei, Atsuta Ikiru, Atsushi Danjo, Haruyoshi Yamaza, Shion Hama, Kento Nishida, Ronghao Tang, Yukari Kyumoto, Norihisa Uehara, Toshio Kukita, Fusanori Nishimura, Takayoshi Yamaza

Scientific Reports   8 ( 1 )   2018.2

IL-1β induces pathologically activated osteoclasts bearing extremely high levels of resorbing activity A possible pathological subpopulation of osteoclasts, accompanied by suppressed expression of kindlin-3 and Talin-1 Reviewed

200 ( 1 )   218 - 228   2018.1

Correction MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma (PLoS ONE (2017) 12:6 (e0180317) DOI: 10.1371/journal.pone.0085935) Reviewed

Ombretta Melaiu, Justin Stebbing, Ylenia Lombardo, Elisa Bracci, Norihisa Uehara, Alessandra Bonotti, Alfonso Cristaudo, Rudy Foddis, Luciano Mutti, Roberto Barale, Federica Gemignani, Georgios Giamas, Stefano Landi

PLoS One   12 ( 6 )   2017.6

Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis Reviewed

Toshio Takano, Yin Ji Li, Akiko Kukita, Takayoshi Yamaza, Yasunori Ayukawa, Kanako Moriyama, Norihisa Uehara, Hisayuki Nomiyama, Kiyoshi Koyano, Toshio Kukita

Laboratory Investigation   94 ( 3 )   286 - 296   2014.3

MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma Reviewed

Ombretta Melaiu, Justin Stebbing, Ylenia Lombardo, Elisa Bracci, Norihisa Uehara, Alessandra Bonotti, Alfonso Cristaudo, Rudy Foddis, Luciano Mutti, Roberto Barale, Federica Gemignani, Georgios Giamas, Stefano Landi

PLoS One   9 ( 1 )   2014.1

Regulation of osteoclastogenesis through Tim-3 Possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction Reviewed

Kanako Moriyama, Akiko Kukita, Yin Ji Li, Norihisa Uehara, Jing Qi Zhang, Ichiro Takahashi, Toshio Kukita

Laboratory Investigation   94 ( 11 )   1200 - 1211   2014.1

Curcumin suppresses n-methyl-n-nitrosourea-induced photoreceptor apoptosis in sprague-dawley rats Reviewed

Yuko Emoto, Katsuhiko Yoshizawa, Norihisa Uehara, Yuichi Kinoshita, Takashi Yuri, Nobuaki Shikata, Airo Tsubura

In Vivo   27 ( 5 )   583 - 590   2013.9

N-Methyl-N-nitrosourea-induced renal tumors in rats Immunohistochemical comparison to human Wilms tumors Reviewed

Katsuhiko Yoshizawa, Yuichi Kinoshita, Yuko Emoto, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Airo Tsubura

Journal of Toxicologic Pathology   26 ( 2 )   141 - 148   2013.7

Histopathological and immunohistochemical characterization of spontaneously occurring uterine deciduomas in young adult rats Reviewed International journal

Katsuhiko Yoshizawa, Yuko Emoto, Yuichi Kinoshita, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Airo Tsubura

Journal of Toxicologic Pathology   26 ( 1 )   61 - 66   2013.6

Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal Preneoplastic lesions in young Lewis rats Reviewed

Katsuhiko Yoshizawa, Yuko Emoto, Yuichi Kinoshita, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Tomohito Hamazaki, Airo Tsubura

Oncology Letters   5 ( 4 )   1112 - 1116   2013.4

Arachidonic acid supplementation during gestational, lactational and post-weaning periods prevents retinal degeneration induced in a rodent model Reviewed

Katsuhiko Yoshizawa, Tomo Sasaki, Maki Kuro, Norihisa Uehara, Hideho Takada, Akiko Harauma, Naoki Ohara, Toru Moriguchi, Airo Tsubura

British Journal of Nutrition   109 ( 8 )   1424 - 1432   2013.4

Two cases of malignant peritoneal mesothelioma without asbestos exposure Cytologic and immunohistochemical features Reviewed

Yuichi Kinoshita, Kosho Takasu, Takashi Yuri, Katsuhiko Yoshizawa, Norihisa Uehara, Ayako Kimura, Hisanori Miki, Airo Tsubura, Nobuaki Shikata

Annals of Diagnostic Pathology   17 ( 1 )   99 - 103   2013.2

Promoting effect of arachidonic acid supplementation on N-methyl-N-nitrosourea--induced pancreatic acinar cell hyperplasia in young Lewis rats Reviewed

Katsuhiko Yoshizawa, Norihisa Uehara, Ayako Kimura, Yuko Emoto, Yuichi Kinoshita, Takashi Yuri, Hideho Takada, Toru Moriguchi, Tomohito Hamazaki, Airo Tsubura

Oncology Letters   5 ( 1 )   76 - 82   2013.1

N-methyl-N-nitrosourea-induced changes in epithelial rests of Malassez and the development of odontomas in rats Reviewed

Ayako Kimura, Katsuhiko Yoshizawa, Tomo Sasaki, Norihisa Uehara, Yuichi Kinoshita, Hisanori Miki, Takashi Yuri, Takashi Uchida, Airo Tsubura

Experimental and Therapeutic Medicine   4 ( 1 )   15 - 20   2012.7

Spontaneously occurring intracranial lipomatous hamartoma in a young BALB/c mouse and a literature review Reviewed

Tomo Sasaki, Katsuhiko Yoshizawa, Yuichi Kinoshita, Hisanori Miki, Ayako Kimura, Takashi Yuri, Norihisa Uehara, Airo Tsubura

Journal of Toxicologic Pathology   25 ( 2 )   179 - 182   2012.7

N-ethyl-N-nitrosourea induces retinal photoreceptor damage in adult rats Reviewed

Katsuhiko Yoshizawa, Tomo Sasaki, Norihisa Uehara, Maki Kuro, Ayako Kimura, Yuichi Kinoshita, Hisanori Miki, Takashi Yuri, Airo Tsubura

Journal of Toxicologic Pathology   25 ( 1 )   27 - 35   2012.3

Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice Reviewed

Sayaka Kanematsu, Katsuhiko Yoshizawa, Norihisa Uehara, Hisanori Miki, Tomo Sasaki, Maki Kuro, Yen Chang Lai, Ayako Kimura, Takashi Yuri, Airo Tsubura

Oncology Reports   26 ( 3 )   603 - 608   2011.9

Calpain inhibition restores basal autophagy and suppresses MNU-induced photoreceptor cell death in mice Reviewed

Maki Kuro, Katsuhiko Yoshizawa, Norihisa Uehara, Hisanori Miki, Kanji Takahashi, Airo Tsubura

In Vivo   25 ( 4 )   617 - 623   2011.7

Corneal damage induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea Reviewed

Katsuhiko Yoshizawa, Tomo Sasaki, Maki Kuro, Hisanori Miki, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Airo Tsubura

In Vivo   25 ( 4 )   609 - 615   2011.7

Retinal degeneration induced in adult mice by a single intraperitoneal injection of N-Ethyl-N-nitrosourea Reviewed

Katsuhiko Yoshizawa, Maki Kuro-Kuwata, Tomo Sasaki, Yen Chang Clark Lai, Sayaka Kanematsu, Hisanori Miki, Ayako Kimura-Kawanaka, Norihisa Uehara, Takashi Yuri, Airo Tsubura

Toxicologic Pathology   39 ( 4 )   606 - 613   2011.6

Anticancer effects of garlic and garlic-derived compounds for breast cancer control Reviewed

Airo Tsubura, Yen Chang Lai, Maki Kuwata, Norihisa Uehara, Katsuhiko Yoshizawa

Anti-Cancer Agents in Medicinal Chemistry   11 ( 3 )   249 - 253   2011.3

Animal models of N-methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials Reviewed

Airo Tsubura, Yen Chang Lai, Hisanori Miki, Tomo Sasaki, Norihisa Uehara, Takashi Yuri, Katsuhiko Yoshizawa

In Vivo   25 ( 1 )   11 - 22   2011.1

Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese macaque (Macaca fuscata). Reviewed

Katsuhiko Yoshizawa, Kazuko Nakao, Mayu Habiro, Kazuko Hayashi, Maki Kuwata, Norihisa Uehara, Takashi Yuri, Kae Nakamura, Airo Tsubura

Toxicologic Pathology   38 ( 7 )   1058 - 1063   2010.12

Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials Reviewed

A. Tsubura, K. Yoshizawa, M. Kuwata, Norihisa Uehara

Histology and Histopathology   25 ( 7 )   933 - 944   2010.7

N-methyl-N-nitrosourea-induced retinal degeneration in mice is independent of the p53 gene. Reviewed

Katsuhiko Yoshizawa, Maki Kuwata, Ayako Kawanaka, Norihisa Uehara, Takashi Yuri, Airo Tsubura

Molecular Vision   15   2919 - 2925   2009.12

Biphasic effect of short-term pregnancy hormone treatment on N-methyl-N-nitrosourea-induced mammary carcinogenesis in young and old rats Reviewed

Yen Chang Lai, Takashi Yuri, Norihisa Uehara, Yoichiro Matsuoka, Sayaka Kanematsu, Airo Tsubura

Molecular Medicine Reports   2 ( 2 )   213 - 220   2009.3

Role of fatty acids in malignancy and visual impairment Epidemiological evidence and experimental studies Reviewed

Airo Tsubura, T. Yuri, K. Yoshizawa, Norihisa Uehara, H. Takada

Histology and Histopathology   24 ( 2 )   223 - 234   2009.2

Estrogen and progesterone treatment mimicking pregnancy for protection from breast cancer Reviewed

Airo Tsubura, Norihisa Uehara, Yoichiro Matsuoka, Katsuhiko Yoshizawa, Takashi Yuri

In Vivo   22 ( 2 )   191 - 202   2008.3

hnRNP U interacts with the c-Myc-Max complex on the E-box promoter region inducing the ornithine decarboxylase gene Reviewed

Yoichiro Matsuoka, Norihisa Uehara, Airo Tsubura

Oncology Reports   22 ( 2 )   249 - 255   2008.2

Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis Reviewed

Yoichiro Matsuoka, Katsumi Fukamachi, Norihisa Uehara, Hiroyuki Tsuda, Airo Tsubura

Cancer Science   99 ( 2 )   309 - 315   2008.2

Effects of prepubertal indole-3-carbinol treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Sprague-Dawley rats Reviewed

Naoto Shimano, Norihisa Uehara, Yasuhiko Kiyozuka, Nobuaki Shikata, Airo Tsubura

In Vivo   21 ( 6 )   983 - 988   2007.11

PARP inhibitors accelerate N-methyl-N-nitrosourea-induced cataractogenesis in Sprague-Dawley rats Reviewed

Katsuaki Miki, Katsuhiko Yoshizawa, Norihisa Uehara, Takashi Yuri, Yoichiro Matsuoka, Airo Tsubura

In Vivo   21 ( 5 )   739 - 744   2007.9

N-methyl-N-nitrosourea-induced mammary carcinogenesis is promoted by short-term treatment with estrogen and progesterone mimicking pregnancy in aged female Lewis rats Reviewed

Reiko Tsukamoto, Takako Mikami, Katsuaki Miki, Norihisa Uehara, Takashi Yuri, Yoichiro Matsuoka, Kazuichi Okazaki, Airo Tsubura

Oncology Reports   18 ( 2 )   337 - 342   2007.8

TAK1 represses transcription of the human telomerase reverse transcriptase gene Reviewed

T. Fujiki, T. Miura, M. Maura, H. Shiraishi, S. Nishimura, Y. Imada, Norihisa Uehara, Kosuke Tashiro, S. Shirahata, Yoshinori Katakura

Oncogene   26 ( 36 )   5258 - 5266   2007.8

Multistep mouse mammary tumorigenesis through preneoplasia to neoplasia and acquisition of metastatic potential Reviewed

Airo Tsubura, Katsuhiko Yoshizawa, Norihisa Uehara, Takashi Yuri, Yoichiro Matsuoka

Medical Molecular Morphology   40 ( 1 )   9 - 17   2007.3

Poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide rescues N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in Sprague-Dawley rats through preservation of nuclear factor-κB activity Reviewed

84 ( 2 )   285 - 292   2007.2

Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells Reviewed

Takashi Yuri, Reiko Tsukamoto, Katsuaki Miki, Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura

Oncology Reports   16 ( 6 )   1307 - 1312   2006.12

Effects of different durations of estrogen and progesterone treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats Reviewed

Takashi Yuri, Reiko Tsukamoto, Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura

In Vivo   20 ( 6 B )   829 - 836   2006.11

Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions Reviewed

19 ( 6 )   959 - 964   2005.11

Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress Reviewed

Yoshinori Katakura, Kaichi Yoshizaki, Tomoharu Yasuda, Takahiro Tsunematsu, Norihisa Uehara, Takumi Miura, Tsukasa Fujiki, Sanetaka Shirahata

Biochemical and Biophysical Research Communications   334 ( 2 )   450 - 459   2005.8

Effects of prepubertal exposure to xenoestrogen on development of estrogen target organs in female CD-1 mice Reviewed

Yasuyoshi Nikaido, Naoyuki Danbara, Miki Tsujita-Kyutoku, Takashi Yuri, Norihisa Uehara, Airo Tsubura

In Vivo   19 ( 3 )   487 - 494   2005.5

Enterolactone induces apoptosis and inhibits growth of colo 201 human colon cancer cells both in vitro and in vivo Reviewed

Naoyuki Danbara, Takashi Yuri, Miki Tsujita-Kyutoku, Reiko Tsukamoto, Norihisa Uehara, Airo Tsubura

Anticancer Research   25 ( 3 B )   2269 - 2276   2005.5

Dietary factors modifying breast cancer risk and relation to time of intake Reviewed

Airo Tsubura, Norihisa Uehara, Yasuhiko Kiyozuka, Nobuaki Shikata

Journal of Mammary Gland Biology and Neoplasia   10 ( 1 )   87 - 100   2005.1

Dietary effects of conjugated docosahexaenoic acid on N-methyl-N- nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats Reviewed

Naoyuki Danbara, Norihisa Uehara, Nobuaki Shikata, Hideho Takada, Takahiko Hada, Airo Tsubura

Oncology Reports   12 ( 5 )   1079 - 1085   2004.11

Effects of prepubertal zeranol exposure on estrogen target organs and N-methyl-N-nitrosourea-induced mammary tumorigenesis in female Sprague-Dawley rats Reviewed

Takashi Yuri, Yasuyoshi Nikaido, Naoto Shimano, Norihisa Uehara, Nobuaki Shikata, Airo Tsubura

In Vivo   18 ( 6 )   755 - 762   2004.11

Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring Reviewed

Yasuyoshi Nikaido, Katsuhiko Yoshizawa, Naoyuki Danbara, Miki Tsujita-Kyutoku, Takashi Yuri, Norihisa Uehara, Airo Tsubura

Reproductive Toxicology   18 ( 6 )   803 - 811   2004.8

Conjugated docosahexaenoic acid suppresses KPL-1 human breast cancer cell growth in vitro and in vivo potential mechanisms of action. Reviewed

Miki Tsujita-Kyutoku, Takashi Yuri, Naoyuki Danbara, Hideto Senzaki, Yasuhiko Kiyozuka, Norihisa Uehara, Hideho Takada, Takahiko Hada, Teruo Miyazawa, Yutaka Ogawa, Airo Tsubura

Breast Cancer Research   6 ( 4 )   2004.4

Neural stem cells lose telomerase activity upon differentiating into astrocytes Reviewed

Takumi Miura, Yoshinori Katakura, Katsuhiko Yamamoto, Norihisa Uehara, Toshie Tsuchiya, Eun Ho Kim, Sanetaka Shirahata

Cytotechnology   36 ( 1-3 )   137 - 144   2001.12

Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma Reviewed

Yoshinori Katakura, Katsuhiko Yamamoto, Osamu Miyake, Tomoharu Yasuda, Norihisa Uehara, Eriko Nakata, Seiji Kawamoto, Sanetaka Shirahata

Biochemical and Biophysical Research Communications   237 ( 2 )   313 - 317   1997.8

ラミニン-332は骨芽細胞で発現し、破骨細胞形成を負に制御する

上原 範久, 久木田 明子, 久本 由香里, 保田 尚孝, 久木田 敏夫

歯科基礎医学会  2017.9 

Extracellular vesicles from bone metastatic mammary tumor cells facilitate osteoclast formation and bone resorption in vitro.

2017.7 

ラミニン-332の骨芽細胞での発現と破骨細胞分化制御

上原 範久, 久木田　明子, 久本 由香里, 保田 尚孝, 久木田　敏夫

日本解剖学会  2017.3 

骨転移性乳癌細胞由来エクソソームを介した破骨細胞分化制御メカニズム

上原 範久, 久本 由香里, 久木田　明子, 久木田　敏夫

日本分子生物学会  2016.12 

Metastatic mammary tumor-derived exosomes promote osteoclast differentiation

2016.7 

ニコチンアミドはヒストン脱アセチル化酵素阻害剤vorinostat誘導細胞死を増強する

上原 範久, 義澤 克彦

日本分子生物学会  2014.11 

Inhibition of in vitro cell motility and invasive potential by microRNA-148a in human breast cancer cells

2013.10 

分泌型miRNAを介した骨転移性癌細胞-破骨細胞間コミュニケーション Invited

上原 範久, 久本 由香里, 久木田　明子, 久木田　敏夫

日本解剖学会  2016.3 

Molecular cloning and characterization of specific genes possibly involved in cellular senescence International conference

N. Uehara, Y. Katakura, K. Teruya, S. Shirahata

The Joint Meeting of the Japanese Association for Animal Cell Technology and the Europian Society for Animal Cell Technology  1998.11 

Subtractive screening of genes involved in cellular senescence International conference

N. Uehara, Y. Katakura, T. Miura, S. Shirahata

World Congress on In Vitro Biology  2000.6 

Involvement of mitochondrial DNA in cellular senescence International conference

N. Uehara, Y. Katakura, T. Miura, S. Shirahata

Annual and International Meeting of the Japanese Association for Animal Cell Technology  2001.11 

Involvement of Id genes in mammary development and its implications to carcinogenesis. International conference

N. Uehara, YC. Chou, J. Galvez, R. Cardiff, G. Shyamala

American association of cancer research annual meeting  2002.4 

経産後乳腺における発癌抑制能の獲得とその機構解明に向けた網羅的遺伝子発現解析

上原範久，清塚康彦，四方伸明，螺良愛郎

日本癌学会  2004.9 

ニコチンアミドによるpoly (ADP-ribose) polymerase (PARP)-1を介したラット視細胞アポトーシスの抑制機序

上原範久，清塚康彦，四方伸明，螺良愛郎

日本病理学会  2004.4 

Nicotinamideによるpoly（ADP-ribose）polymerase-1を介したラット視細胞アポトーシスの抑制

上原範久，清塚康彦，四方伸明，螺良愛郎

日本組織細胞化学会  2004.10 

経産後乳腺における発癌剤刺激応答と発癌抑制機構の解析

上原範久，清塚康彦，松岡洋一郎，四方伸明，螺良愛郎

日本病理学会  2005.4 

経産後乳腺における発癌剤刺激応答と発癌抑制機構解明に向けた網羅的遺伝子発現解析

上原範久、清塚康彦、四方伸明、螺良愛郎

日本分子生物学会  2005.12 

経産乳腺における発癌抑制機序解明に向けた特異的制御遺伝子の単離とその機能解析

上原範久, 清塚康彦, 松岡洋一郎, 螺良愛郎

日本病理学会  2006.4 

経産乳腺特異的遺伝子の単離とヒト乳癌細胞株増殖に及ぼす影響

上原範久, 清塚康彦, 松岡洋一郎, 螺良愛郎

日本癌学会  2006.9 

Alterations in gene expression before and after carcinogenic stimuli on parous mammary glands in Lewis rats International conference

A. Tsubura, N. Uehara, Y. Kiyozuka, T. Yuri, Y. Matsuoka

International association of breast cancer research annual meeting  2006.9 

Mesothelin過剰発現乳癌細胞株における足場非依存的増殖促進とanoikis抑制機構の解明

上原範久、松岡洋一郎、螺良愛郎

日本病理学会  2007.3 

Mesothelin過剰発現乳癌細胞株における足場非依存的増殖促進とERKシグナル経路を介したanoikis抑制機序

上原範久、松岡洋一郎、螺良愛郎

乳癌基礎研究会  2007.7 

Mesothelin promotes anchorage independent growth and prevents anoikis via ERK signaling pathway in human breast cancer cells

N. Uehara, Y. Matsuoka, A. Tsubura

2007.10 

ヒストン脱アセチル化酵素阻害剤の乳癌細胞増殖抑制におけるp38MAPK活性化の関与

上原範久、兼松清果、松岡洋一郎、螺良愛郎

日本分子生物学会  2007.12 

ヒストン脱アセチル化酵素阻害剤の乳癌細胞増殖抑制機序とp38MAPK活性化の関与

上原範久、兼松清果、松岡洋一郎、螺良愛郎

日本病理学会  2008.5 

Molecular mechanisms of suberoylanilide hydroxamic acid-induced G2/M arrest in human breast cancer (MDA-MB-231) cells

2008.10 

ヒストン脱アセチル化酵素阻害剤によるSkp2, Cks1発現制御とp27の安定化

上原範久、兼松清果、松岡洋一郎、螺良愛郎

日本分子生物学会  2008.12 

ヒストン脱アセチル化酵素阻害剤によるMAPキナーセシグナルを介した乳癌細胞死誘導機序

上原範久、兼松清果、松岡洋一郎、螺良愛郎

日本病理学会  2009.5 

妊娠を契機とした乳腺発癌耐性獲得の分子基盤

上原範久、螺良愛郎

日本臨床分子形態学会  2009.9 

Role of p38MAPK in a cell-death pathway triggered by suberoylanilide hydroxamic acid (SAHA) in human breast cancer cells

N. Uehara, Y. Matsuoka, A. Tsubura

2009.10 

ヒストン脱アセチル化酵素阻害剤による乳癌細胞アポトーシス誘導 〜p38活性化シグナル経路の解析〜

上原範久、兼松清果、三城弥範、義澤克彦、螺良愛郎

日本病理学会  2010.4 

Role of p38MAPK in a cell-death pathway triggered by vorinostat in human breast cancer MDA-MB-231 cells

N. Uehara, S. Kanematsu, H. Miki, K. Yoshizawa, A. Tsubura

2010.7 

Vorinostat induces H2AX phosphorylation through p38 MAPK pathway in human breast cancer cells

N. Uehara, Y. Matsuoka, A. Tsubura

2010.9 

HDAC阻害剤vorinostatのヒト乳癌細胞株に対するDNA損傷応答シグナルへの影響

上原範久, 三城弥範, 義澤克彦, 螺良愛郎

日本病理学会  2011.4 

Vorinostat enhances protein stability of p27 through negative regulatin of Skp2 and Cks1 in human breast cancer cells

N. Uehara, Yoshizawa, A. Tsubura

2011.10 

Identification of tumor suppressive miRNAs induced by histone deacetlase inhibitor vorinostat in human breast cancver cells.

N. Uehara, Yoshizawa, A. Tsubura

2011.12 

Vorinostat誘導乳癌細胞増殖抑制におけるSkp2、Cks1発現抑制とp27、p21の安定化

上原範久, 義澤克彦, 螺良愛郎

日本病理学会  2012.4 

Vorinostat誘導乳癌細胞増殖抑制におけるmiR-148a発現とその役割

上原範久

日本がん分子標的治療学会  2012.6 

MicroRNA-148a suppresses cell migration and invasion in human breast cancer cells: possible involvement of epithelial-mesenchimal transition pathway

Norihisa Uehara*, Katsuhiko Yoshizawa, Ayako Kimura, Airo Tsubura

2012.12 

細胞外マトリックス分子ラミニン３３２による破骨細胞分化制御とJNKシグナルの関与

上原 範久, 久木田 明子, 保田 尚孝, 久木田 敏夫

日本骨代謝学会  2014.7 

細胞外マトリックス分子ラミニン３３２は破骨細胞形成を負に制御する

上原 範久, 久木田 明子, 久本 由香里, 保田 尚孝, 久木田 敏夫

歯科基礎医学会  2014.9 

ラミニン-332によるRANK発現調節とマクロファージ-破骨細胞分化転換

上原 範久, 久木田明子, 久本 由香里, 保田尚孝, 久木田 敏夫

日本骨代謝学会学術集会  2015.7 

細胞外マトリックス分子ラミニン332の破骨細胞形成抑制作用

上原 範久, 久木田 明子, 久本 由香里, 保田 尚孝, 久木田 敏夫

西日本骨・関節関連疾患懇話会  2015.7 

骨芽細胞特異的な骨改造制膜表面分子の同定:アルカリ 微小環境による石灰化制御の可能性について

日浦 秀暢、久本 由香里，顧 炯炎、張 旌旗、上原 範久、山座 孝義、久木田明子、高橋 一郎、久木田敏夫

第３９回日本骨代謝学会  2021.10 

骨吸収および炎症性骨破壊における破骨細胞形成と細胞膜ナノチューブの関与

張 旌旗、顧 炯炎、久本 由香里、久木田 明子、張 暁旭、上原 範久、日浦 秀暢、山座 孝義、久木田 敏夫

第62回歯科基礎医学会  2020.9 

胆道閉鎖症患児由来乳歯幹細胞の細胞移植治療効果を制御する機序の解析

園田 聡一朗、村田 早羅、加藤 大樹、久本 由香里、上原 範久、久木田 敏夫、山座 孝義

第62回歯科基礎医学会  2020.9 

骨芽細胞特異的な骨改造制御膜表面分子の同定と機能解析

日浦 秀暢、久本 由香里、上原 範久、張 旌旗、顧 炯炎、山座 孝義、久木田 明子、高橋 一郎、久木田 敏夫

第62回歯科基礎医学会  2020.9 

免疫調節膜表面分子Tim-3の破骨細胞での発現と炎症性骨破壊制御

森山 加奈子, 久木田　明子, 上原 範久, 久本 由香里, 張　旌旗, 髙橋 一郎, 久木田 敏夫

歯科基礎医学会  2014.9 

Id-3 is a potential mediator of progesterone receptor dependent proliferation and apoptosis in mammary glands of PR-A transgenic mice. International conference

YC. Chou, N. Uehara, G. Shyamala

Endocrine society annual meeting  2002.6 

炎症抑制性因子ガレクチン 9 の膜表面受容体 Tim3 を介した破骨細胞形成制御

森山 加奈子, 久木田 明子, 上原 範久, 張 旌旗, 高橋 一郎, 久木田 敏夫

歯科基礎医学会  2013.9 

膜ナノチューブを介する破骨前駆細胞間融合の走査電顕的解析

張 旌旗、高橋 良、久木田 明子、成松 加奈子、上原 範久、山座 孝義、城戸 瑞穂、久木田 敏夫

歯科基礎医学会  2013.9 

炎症抑制因子ガレクチン9の膜表面受容体Tim-3を介した破骨細胞形成制御

森山 加奈子, 久木田 明子, 上原 範久, 張 旌旗, 高橋 一郎, 久木田 敏夫

西日本骨・関節関連疾患懇話会  2014.7 

免疫制御膜表面分子Tim-3を介する炎症性骨破壊制御

森山 加奈子, 久木田 明子, 上原 範久, 久本 由香里, 高橋 一郎, 久木田 敏夫

日本骨代謝学会  2014.7 

Multistep mouse mammary tumorigenesis through pre-neoplasia to neoplasia and acquisition of metastatic potential.

A. Tsubura, K. Yoshizawa, N. Uehara, T. Yuri, Y. Matsuoka

Med Mol Morphol   2007.3

Dietary factors modifying breast cancer risk and relation to time of intake.

A. Tsubura, N. Uehara, Y. Kiyozuka, N. Shikata

J Mammary Gland Biol Neoplasia   2005.1

シンポジウムオーガナイザー

日本解剖学会  （ 東京 ） 2018.3

Screening of academic papers

Role(s)： Peer review

2018

Screening of academic papers

Role(s)： Peer review

2017

シンポジスト

日本解剖学会  （ 福島 ） 2016.3

Screening of academic papers

Role(s)： Peer review

2016

幹事

老化研究会  （ 九州大学 大阪オフィス ） 2013.12

幹事

老化研究会  （ 九州大学 ） 2012.12

幹事

老化研究会  （ 順天堂大学 ） 2011.9

シンポジスト

日本臨床分子形態学会  （ 神戸国際会議場 ） 2009.9

アラキドン酸によるMNU誘発網膜色素変性症動物モデルの病態制御とその分子機構

Grant number：24592661  2012 - 2014

日本学術振興会  科学研究費助成事業  基盤研究(C)

HDAC制御を介した癌抑制における新規標的マイクロRNAの探索と治療への展開

2011

大阪コミュニティ財団　がん研究助成

MNU誘発網膜色素変性症動物モデルにおけるオートファジーの関与とその分子制御

Grant number：22591954  2010 - 2012

日本学術振興会  科学研究費助成事業  基盤研究(C)

HDAC制御を介した癌抑制における新規標的マイクロRNAの探索と治療への展開

Grant number：22791263  2010 - 2011

科学研究費助成事業  若手研究(B)

スルフォラファンのオートファジーを介する乳癌細胞死滅機構の同定と癌治療への応用

Grant number：21591683  2009 - 2010

日本学術振興会  科学研究費助成事業  基盤研究(C)

アセチル化修飾による細胞周期制御の分子機構と乳癌抑制に向けた新規標的分子の探索

Grant number：20790940  2008 - 2009

科学研究費助成事業  若手研究(B)

HDAC阻害剤によるSCFユビキチンリガーゼ複合体制御の分子基盤と乳癌治療への応用

2008

大阪対ガン協会

未産・経産ラット乳腺のDNAメチル化状態の網羅的比較による乳癌予防

Grant number：19591522  2007 - 2008

日本学術振興会  科学研究費助成事業  基盤研究(C)

アセチル化修飾を介したヒト乳癌細胞増殖抑制における細胞質分裂制御の役割

2007

大阪対ガン協会

経産乳腺の発癌抵抗性獲得におけるエピジェネティクスと遺伝子発現制御機構の解明

Grant number：18790947  2006 - 2007

科学研究費助成事業  若手研究(B)

経産後乳腺における発癌刺激応答と癌抑制機構の分子生物学的解明

2006

藤田記念医学研究研究振興基金

Mesothelinによる足場非依存的増殖促進とanoikis耐性獲得機構の解明

2006

大阪対ガン協会

妊娠期ホルモン環境を模倣した乳癌予防プロトコールの確立とその分子基盤の解明

Grant number：17591361  2005 - 2006

日本学術振興会  科学研究費助成事業  基盤研究(C)

周生期Zeranol摂取による発育・発癌への影響

Grant number：16510047  2004 - 2005

日本学術振興会  科学研究費助成事業  基盤研究(C)

経産後乳腺における発癌抑制能の獲得とその機構解明に向けた分子生物学的アプローチ

Grant number：16790766  2004 - 2005

科学研究費助成事業  若手研究(B)

解剖学

2023.4 - 2024.3   Full year

発生学

2023.4 - 2023.6   Spring quarter

口腔組織学3

2022.12 - 2023.2   Winter quarter

口腔組織学2

2022.10 - 2022.12   Fall quarter

口腔組織学1

2022.6 - 2022.8   Summer quarter

分子口腔解剖学

2022.4 - 2023.3   Full year

口腔解剖学

2022.4 - 2023.3   Full year

解剖学

2022.4 - 2023.3   Full year

リサーチエクスポージャー

2022.4 - 2022.6   Spring quarter

発生学

2022.4 - 2022.6   Spring quarter

口腔組織学II

2021.10 - 2022.3   Second semester

分子口腔解剖学演習

2021.4 - 2022.3   Full year

分子口腔解剖学

2021.4 - 2022.3   Full year

解剖学

2021.4 - 2022.3   Full year

リサーチエクスポージャー

2021.4 - 2022.3   Full year

口腔組織学I

2021.4 - 2021.9   First semester

アーリーエクスポージャー

2021.4 - 2021.6   Spring quarter

口腔組織学II 実習

2020.10 - 2021.3   Second semester

分子口腔解剖学演習

2020.4 - 2021.3   Full year

分子口腔解剖学

2020.4 - 2021.3   Full year

解剖学

2020.4 - 2020.9   First semester

口腔組織学I

2020.4 - 2020.9   First semester

口腔組織学II 実習

2019.10 - 2020.3   Second semester

口腔組織学II

2019.10 - 2020.3   Second semester

分子口腔解剖学演習

2019.4 - 2020.3   Full year

分子口腔解剖学

2019.4 - 2020.3   Full year

硬組織研究法

2019.4 - 2020.3   Full year

リサーチエクスポージャー

2019.4 - 2020.3   Full year

解剖学

2019.4 - 2019.9   First semester

口腔組織学I

2019.4 - 2019.9   First semester

口腔組織学II

2018.10 - 2019.3   Second semester

口腔組織学II 実習

2018.10 - 2019.3   Second semester

リサーチエクスポージャー

2018.4 - 2019.3   Full year

分子口腔解剖学演習

2018.4 - 2019.3   Full year

分子口腔解剖学

2018.4 - 2019.3   Full year

硬組織研究法

2018.4 - 2019.3   Full year

アーリーエクスポージャー

2018.4 - 2018.9   First semester

口腔組織学I

2018.4 - 2018.9   First semester

解剖学

2018.4 - 2018.9   First semester

アーリーエクスポージャー

2018.4 - 2018.9   First semester

口腔組織学II

2017.10 - 2018.3   Second semester

口腔組織学II 実習

2017.10 - 2018.3   Second semester

分子口腔解剖学演習

2017.4 - 2018.3   Full year

硬組織研究法

2017.4 - 2018.3   Full year

分子口腔解剖学

2017.4 - 2018.3   Full year

口腔組織学I

2017.4 - 2017.9   First semester

解剖学

2017.4 - 2017.9   First semester

口腔組織学II 実習

2016.10 - 2017.3   Second semester

口腔組織学II (舌･味蕾）

2016.10 - 2017.3   Second semester

硬組織研究法

2016.4 - 2017.3   Full year

分子口腔解剖学演習

2016.4 - 2017.3   Full year

分子口腔解剖学

2016.4 - 2017.3   Full year

解剖学

2016.4 - 2016.9   First semester

発生学（骨格系）

2016.4 - 2016.9   First semester

口腔組織学I

2016.4 - 2016.9   First semester

口腔組織学I (舌･味蕾）

2015.10 - 2016.3   Second semester

口腔組織学II 実習

2015.10 - 2016.3   Second semester

分子口腔解剖学演習

2015.4 - 2016.3   Full year

硬組織研究法

2015.4 - 2016.3   Full year

分子口腔解剖学

2015.4 - 2016.3   Full year

口腔組織学I

2015.4 - 2015.9   First semester

解剖学

2015.4 - 2015.9   First semester

発生学（骨格系）

2015.4 - 2015.9   First semester

硬組織研究法

2014.4 - 2015.3   Full year

解剖学

2014.4 - 2015.3   Full year

分子口腔解剖学演習

2014.4 - 2015.3   Full year

分子口腔解剖学

2014.4 - 2015.3   Full year

口腔組織学II

2014.4 - 2014.9   First semester

口腔細胞生物学

2014.4 - 2014.9   First semester

硬組織研究法

2013.4 - 2014.3   Full year

分子口腔解剖学

2013.4 - 2014.3   Full year

解剖学

2013.4 - 2014.3   Full year

分子口腔解剖学演習

2013.4 - 2014.3   Full year

口腔組織学II

2013.4 - 2013.9   First semester

口腔細胞生物学

2013.4 - 2013.9   First semester

アーリーエクスポージャII

2013.4 - 2013.9   First semester

2020.6   Role：Participation   Title：電子ジャーナルをめぐる現状と今後に向けた対応について

Organizer：[Undergraduate school/graduate school/graduate faculty]

2019.9   Role：Participation   Title：科研費申請のススメ

Organizer：[Undergraduate school/graduate school/graduate faculty]

2018.8   Role：Participation   Title：歯学研究院FD 「SciVal及びPureに関する説明会」

Organizer：[Undergraduate school/graduate school/graduate faculty]

2018.7   Role：Participation   Title：平成33年度入学者選抜改革【九州大学新入試QUBE】

Organizer：University-wide

2017.10   Role：Participation   Title：平成２９年度 病院地区４部局合同男女共同参画FD　「無意識のバイアスからの開放：ダイバーシティのススメ」

Organizer：University-wide

2016.12   Role：Participation   Title：歯学教育の現状と課題

Organizer：[Undergraduate school/graduate school/graduate faculty]

2016.2   Role：Participation   Title：ルーブリック作成に関するFD研修会

Organizer：Undergraduate school department

2014.9   Role：Participation   Title：科研費獲得のポイント

Organizer：[Undergraduate school/graduate school/graduate faculty]

2014.8   Role：Participation   Title：新ＧＰＡ制度実施のためのＦＤ

Organizer：University-wide

2013.4   Role：Participation   Title：新任教員の研修

Organizer：University-wide