Updated on 2024/10/01

Information

 

写真a

 
TAKAI SHINGO
 
Organization
Faculty of Dental Science Department of Dental Science Assistant Professor
School of Dentistry Department of Dentistry（Concurrent）
Graduate School of Dental Science （Concurrent）
Graduate School of Dental Science Department of Dental Science（Concurrent）
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926426312
Profile
My primary research interest is to understand the perception, transmission, and modulation of taste sensation. I am tackling to exam the taste transduction mechanism and development of mammal taste tissue.
External link

Research Areas

  • Life Science / Physiology

  • Life Science / Oral biological science

  • Life Science / Clinical pharmacy

Degree

  • Ph. D. in Dental science, Kyushu University ( 2015.3 )

Research History

  • Kyushu University Dental School Oral neuroscience Assistant Professor

    2016.4 - Present

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  • 2010-2011　医療法人周和会にしはら歯科医院、九州大学病院口腔総合診療科（臨床研修歯科医）

    2010-2011　医療法人周和会にしはら歯科医院、九州大学病院口腔総合診療科（臨床研修歯科医）

  • 2012-2014　日本学術振興会特別研究員（DC1）

Research Interests・Research Keywords

  • Research theme：physiology

    Keyword：physiology

    Research period： 2024

  • Research theme：taste

    Keyword：taste

    Research period： 2024

  • Research theme：molecular biology

    Keyword：molecular biology

    Research period： 2024

  • Research theme：The gastrointestinal hormones and their receptors in the peripheral taste tissue

    Keyword：taste

    Research period： 2017.4 - 2019.3

  • Research theme：Transmission and regulation of taste sense

    Keyword：Taste Physiology

    Research period： 2016.4

Awards

  • 令和2年度がん研究助成金　入賞

    2021.2   公益財団法人　ふくおか公衆衛生推進機構   ヒアルロン酸シグナリングに着目したがん治療に伴う味覚障害治療法の創出

  • 第49回日本味と匂学会論文賞

    2015.10   日本味と匂学会   「味神経に発現するGLP-1レセプターとその役割」

  • 第55回歯科基礎医学会学術大会優秀ポスター発表賞受賞

    2013.9   歯科基礎医学会   「マウス味蕾における甘味特異的なGLP-1の分泌」

Papers

  • Effects of insulin signaling on mouse taste cell proliferation Reviewed International journal

    Shingo Takai, Yu Watanabe, Keisuke Sanematsu, Ryusuke Yoshida, Robert F. Margolskee, Peihua Jiang, Ikiru Atsuta, Kiyoshi Koyano, Yuzo Ninomiya, Noriatsu Shigemura

    PloS one   14 ( 11 )   2019.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0225190

  • Relationship between olfactory and gustatory functions: The Iwaki health promotion project 2019 Reviewed

    Kazutaka Yamauchi, Daisuke Matsushita, Nami Shimizume, Reiko Kudo, Yusuke Kohama, Akiko Miyazaki, Hiromu Taguchi, Takashi Hirao, Fuminori Kawabata, Yuko Kawabata, Keisuke Sanematsu, Shingo Takai, Junichi Yamazoe, Kenichi Anabuki, Ken Aoshima, Yoshiko Takahashi, Shinichi Goto, Akira Sasaki, Noriatsu Shigemura, Atsushi Matsubara

    Auris Nasus Larynx   51 ( 3 )   443 - 449   2024.6   （ ISSN:0385-8146 eISSN:1879-1476 ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.anl.2023.12.009

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  • Cellular mechanisms of taste disturbance induced by the non-steroidal anti-inflammatory drug, diclofenac, in mice. Reviewed International journal

    Ayaka Hirayama, Shusuke Iwata, Asami Oike, Yuko Kawabata, Yuki Nagasato, Shingo Takai, Keisuke Sanematsu, Ichiro Takahashi, Noriatsu Shigemura

    Frontiers in cellular neuroscience   17   1279059 - 1279059   2023.12   （ ISSN:16625102 eISSN:1662-5102 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    Drug-induced taste disorders are a serious problem in an aging society. This study investigated the mechanisms underlying taste disturbances induced by diclofenac, a non-steroidal anti-inflammatory drug that reduces pain and inflammation by inhibiting the synthesis of prostaglandins by cyclooxygenase enzymes (COX-1 and COX-2). RT-PCR analyses demonstrated the expression of genes encoding arachidonic acid pathway components such as COX-1, COX-2 and prostaglandin synthases in a subset of mouse taste bud cells. Double-staining immunohistochemistry revealed that COX-1 and cytosolic prostaglandin E synthase (cPGES) were co-expressed with taste receptor type-1 member-3 (T1R3), a sweet/umami receptor component, or gustducin, a bitter/sweet/umami-related G protein, in a subset of taste bud cells. Long-term administration of diclofenac reduced the expression of genes encoding COX-1, gustducin and cPGES in mouse taste buds and suppressed both the behavioral and taste nerve responses to sweet and umami taste stimuli but not to other tastants. Furthermore, diclofenac also suppressed the responses of both mouse and human sweet taste receptors (T1R2/T1R3, expressed in HEK293 cells) to sweet taste stimuli. These results suggest that diclofenac may suppress the activation of sweet and umami taste cells acutely via a direct action on T1R2/T1R3 and chronically via inhibition of the COX/prostaglandin synthase pathway inducing down-regulated expression of sweet/umami responsive components. This dual inhibition mechanism may underlie diclofenac-induced taste alterations in humans.

    DOI： 10.3389/fncel.2023.1279059

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  • The antiarrhythmic drug flecainide enhances aversion to HCl in mice. Reviewed International journal

    Yuko Kawabata, Shingo Takai, Keisuke Sanematsu, Ryusuke Yoshida, Fuminori Kawabata, Noriatsu Shigemura

    eNeuro   10 ( 9 )   2023.9   （ eISSN:2373-2822 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    Drug-induced taste disorders reduce quality of life, but little is known about the molecular mechanisms by which drugs induce taste disturbances. In this study, we investigated the short- and long-term effects of the antiarrhythmic drug flecainide, which is known to cause taste dysfunction. Analyses of behavioral responses (licking tests) revealed that mice given a single intraperitoneal injection of flecainide exhibited a significant reduction in preference for a sour tastant (HCl) but not for other taste solutions (NaCl, quinine, sucrose, KCl and monopotassium glutamate) when compared with controls. Mice administered a single dose of flecainide also had significantly higher taste nerve responses to HCl but not to other taste solutions. Compared with controls, mice administered flecainide once-daily for 30 days showed a reduced preference for HCl without any changes in the behavioral responses to other taste solutions. The electrophysiological experiments using HEK293T cells transiently expressing otopetrin-1 (Otop1, the mouse sour taste receptor) showed that flecainide rarely altered the responses to HCl. Taken together, our results suggest that flecainide specifically enhances the response to HCl in mice during short- and long- term administration. Although further studies will be needed to elucidate the molecular mechanisms, these findings provide new insights into the pathophysiology of drug-induced taste disorders.Significance StatementDrug-induced taste disorders reduce quality of life and can lead to nutritional disturbances. However, little is known about its molecular mechanisms. We focused on the antiarrhythmic drug flecainide inducing "unpleasant or bad taste" in human patients. Mice administered a single dose of flecainide exhibited a reduced preference for and higher taste nerve responses to HCl, sour tastants specifically. Flecainide had little change in response to HCl in HEK293T cells expressing the sour taste receptor, proton channel otopetrin-1 (Otop1). Our results suggest that flecainide enhances the responses of sour-sensing taste cells to HCl. Although further studies will be needed to elucidate the molecular mechanisms, these findings provide new insights into the pathophysiology of drug-induced taste disorders.

    DOI： 10.1523/ENEURO.0048-23.2023

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  • The G protein‐coupled receptor GPRC5C is a saccharide sensor with a novel “off” response Reviewed International journal

    Yuko Kawabata, Shingo Takai, Keisuke Sanematsu, Shusuke Iwata, Fuminori Kawabata, Takashi Kanematsu, Eijiro Jimi, Noriatsu Shigemura

    FEBS Letters   597 ( 15 )   2006 - 2016   2023.7   （ ISSN:0014-5793 eISSN:1873-3468 ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/1873-3468.14695

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  • Adrenomedullin Enhances Mouse Gustatory Nerve Responses to Sugars via T1R-Independent Sweet Taste Pathway Reviewed International journal

    Shusuke Iwata, Ryusuke Yoshida, Shingo Takai, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

    Nutrients   15 ( 13 )   2941 - 2941   2023.6   （ eISSN:2072-6643 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    On the tongue, the T1R-independent pathway (comprising glucose transporters, including sodium–glucose cotransporter (SGLT1) and the KATP channel) detects only sugars, whereas the T1R-dependent (T1R2/T1R3) pathway can broadly sense various sweeteners. Cephalic-phase insulin release, a rapid release of insulin induced by sensory signals in the head after food-related stimuli, reportedly depends on the T1R-independent pathway, and the competitive sweet taste modulators leptin and endocannabinoids may function on these two different sweet taste pathways independently, suggesting independent roles of two oral sugar-detecting pathways in food intake. Here, we examined the effect of adrenomedullin (ADM), a multifunctional regulatory peptide, on sugar sensing in mice since it affects the expression of SGLT1 in rat enterocytes. We found that ADM receptor components were expressed in T1R3-positive taste cells. Analyses of chorda tympani (CT) nerve responses revealed that ADM enhanced responses to sugars but not to artificial sweeteners and other tastants. Moreover, ADM increased the apical uptake of a fluorescent D-glucose derivative into taste cells and SGLT1 mRNA expression in taste buds. These results suggest that the T1R-independent sweet taste pathway in mouse taste cells is a peripheral target of ADM, and the specific enhancement of gustatory nerve responses to sugars by ADM may contribute to caloric sensing and food intake.

    DOI： 10.3390/nu15132941

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  • Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3. Reviewed International journal

    Keisuke Sanematsu, Masato Yamamoto, Yuki Nagasato, Yuko Kawabata, Yu Watanabe, Shusuke Iwata, Shingo Takai, Kiyoshi Toko, Toshiro Matsui, Naohisa Wada, Noriatsu Shigemura

    Communications biology   6 ( 1 )   340 - 340   2023.4   （ eISSN:2399-3642 ）

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    The sweet taste receptor plays an essential role as an energy sensor by detecting carbohydrates. However, the dynamic mechanisms of receptor activation remain unclear. Here, we describe the interactions between the transmembrane domain of the G protein-coupled sweet receptor subunit, TAS1R3, and allosteric modulators. Molecular dynamics simulations reproduced species-specific sensitivity to ligands. We found that a human-specific sweetener, cyclamate, interacted with the mouse receptor as a negative allosteric modulator. Agonist-induced allostery during receptor activation was found to destabilize the intracellular part of the receptor, which potentially interfaces with the Gα subunit, through ionic lock opening. A common human variant (R757C) of the TAS1R3 exhibited a reduced response to sweet taste, in support of our predictions. Furthermore, histidine residues in the binding site acted as pH-sensitive microswitches to modulate the sensitivity to saccharin. This study provides important insights that may facilitate the prediction of dynamic activation mechanisms for other G protein-coupled receptors.

    DOI： 10.1038/s42003-023-04705-5

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  • Ascl1-expressing cell differentiation in initially developed taste buds and taste organoids. Reviewed International journal

    Kae Matsuyama, Shingo Takai, Noriatsu Shigemura, Mitsushiro Nakatomi, Tatsuo Kawamoto, Shinji Kataoka, Takashi Toyono, Yuji Seta

    Cell and tissue research   392 ( 3 )   631 - 641   2023.2   （ ISSN:0302-766X eISSN:1432-0878 ）

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    Mammalian taste bud cells are composed of several distinct cell types and differentiated from surrounding tongue epithelial cells. However, the detailed mechanisms underlying their differentiation have yet to be elucidated. In the present study, we examined an Ascl1-expressing cell lineage using circumvallate papillae (CVP) of newborn mice and taste organoids (three-dimensional self-organized tissue cultures), which allow studying the differentiation of taste bud cells in fine detail ex vivo. Using lineage-tracing analysis, we observed that Ascl1 lineage cells expressed type II and III taste cell markers both CVP of newborn mice and taste organoids. However, the coexpression rate in type II cells was lower than that in type III cells. Furthermore, we found that the generation of the cells which express type II and III cell markers was suppressed in taste organoids lacking Ascl1-expressing cells. These findings suggest that Ascl1-expressing precursor cells can differentiate into both type III and a subset of type II taste cells.

    DOI： 10.1007/s00441-023-03756-8

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  • Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells. Reviewed International journal

    Asami Oike, Shusuke Iwata, Ayaka Hirayama, Yurika Ono, Yuki Nagasato, Yuko Kawabata, Shingo Takai, Keisuke Sanematsu, Naohisa Wada, Noriatsu Shigemura

    Scientific reports   12 ( 1 )   21246 - 21246   2022.12   （ ISSN:2045-2322 ）

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    Little is known about the molecular mechanisms underlying drug-induced taste disorders, which can cause malnutrition and reduce quality of life. One of taste disorders is known adverse effects of bisphosphonates, which are administered as anti-osteoporotic drugs. Therefore, the present study evaluated the effects of risedronate (a bisphosphonate) on taste bud cells. Expression analyses revealed that farnesyl diphosphate synthase (FDPS, a key enzyme in the mevalonate pathway) was present in a subset of mouse taste bud and tongue epithelial cells, especially type III sour-sensitive taste cells. Other mevalonate pathway-associated molecules were also detected in mouse taste buds. Behavioral analyses revealed that mice administered risedronate exhibited a significantly enhanced aversion to HCl but not for other basic taste solutions, whereas the taste nerve responses were not affected by risedronate. Additionally, the taste buds of mice administered risedronate exhibited significantly lower mRNA expression of desmoglein-2, an integral component of desmosomes. Taken together, these findings suggest that risedronate may interact directly with FDPS to inhibit the mevalonate pathway in taste bud and tongue epithelial cells, thereby affecting the expression of desmoglein-2 related with epithelial barrier function, which may lead to alterations in behavioral responses to HCl via somatosensory nerves.

    DOI： 10.1038/s41598-022-25755-5

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  • Examination of Taste Threshold for General Residents―From the Results of the 2019 Iwaki Health Promotion Project― Reviewed

    Nami Shimizume, Reiko Kudo, Yusuke Kohama, Yuko Kawabata, Fuminori Kawabata, Keisuke Sanematsu, Nozomi Uemura, Shingo Takai, Junichi Yamazoe, Akiko Miyazaki, Hiromu Taguchi, Takashi Hirao, Shiori Miura, Shinichi Goto, Akira Sasaki, Noriatsu Shigemura, Atsushi Matsubara

    Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo)   125 ( 9 )   1375 - 1383   2022.9   （ ISSN:24365793 eISSN:24365866 ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Otorhinolaryngology-Head and Neck Surgery  

    <p>　Taste is an important sense that is associated with appetite and food intake. Although many studies have been reported on taste detection tests in patients with taste disorders, few studies have been conducted in healthy subjects.</p><p>　The Iwaki Health Promotion Project is a large-scale epidemiological survey of local residents. In the present study, participants in Project 2019 were tested for sweet, salty, sour, and bitter taste thresholds, and 1027 participants for whom data were available were included in the analysis.</p><p>　A comparison of the taste thresholds among the age groups showed that the sour and salty tastes thresholds increased significantly with age, and the thresholds for all tastes was significantly lower in women than in men. In addition, decreased serum zinc levels were not necessarily associated with decreased taste, but decreased serum zinc levels and decreased taste were more frequently observed in the elderly. There were quite a few patients who were not aware of any taste disorder, even though they had a decreased sense of taste on examination. This indicates that there are potential patients with taste disorders.</p>

    DOI： 10.3950/jibiinkotokeibu.125.9_1375

    CiNii Research

  • Gene expression profiling of α-gustducin-expressing taste cells in mouse fungiform and circumvallate papillae Reviewed International journal

    2021.6

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    DOI： 10.1016/j.bbrc.2021.04.022

  • インスリンシグナルの末梢味覚器における役割 味細胞の機能調節から分化／増殖に対する影響まで Invited Reviewed

    髙井 信吾, 重村 憲徳

    化学と生物   Vol.59 ( No.3 )   122 - 129   2021.3

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  • Drinking Ice-Cold Water Reduces the Severity of Anticancer Drug-Induced Taste Dysfunction in Mice. Reviewed International journal

    Ayana Osaki, Keisuke Sanematsu, Junichi Yamazoe, Fumie Hirose, Yu Watanabe, Yuko Kawabata, Asami Oike, Ayaka Hirayama, Yu Yamada, Shusuke Iwata, Shingo Takai, Naohisa Wada, Noriatsu Shigemura

    International journal of molecular sciences   21 ( 23 )   2020.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/ijms21238958

  • Insulin function in peripheral taste organ homeostasis Reviewed International journal

    Takai S, Shigemura N

    Current Oral Health Reports   7   168 - 173   2020.3

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    DOI： 10.1007/s40496-020-00266-2

  • Expression of protocadherin-20 in mouse taste buds Reviewed International journal

    Fumie Hirose, Shingo Takai, Ichiro Takahashi, Noriatsu Shigemura

    Scientific Reports   10 ( 1 )   2020.2

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    DOI： 10.1038/s41598-020-58991-8

  • Expression of Renin-Angiotensin System Components in the Taste Organ of Mice Reviewed International journal

    Noriatsu Shigemura, Shingo Takai, Fumie Hirose, Ryusuke Yoshida, Keisuke Sanematsu, Yuzo Ninomiya

    Nutrients   11 ( 9 )   2019.9

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    DOI： 10.3390/nu11092251

  • ヒト味覚認知閾値に対する低濃度塩添加の影響 Reviewed

    吉田 竜介, 實松 敬介, 高井 信吾, 岩田 周介, 重村 憲徳

    日本味と匂学会誌   ( 第53回大会Proceeding集 )   S35 - S38   2019.9

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  • Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae Reviewed

    Ryusuke Yoshida, Shingo Takai, Keisuke Sanematsu, Robert F. Margolskee, Noriatsu Shigemura, Yuzo Ninomiya

    Neuroscience   369   29 - 39   2018.1

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    DOI： 10.1016/j.neuroscience.2017.10.047

  • The role of cholecystokinin in peripheral taste signaling in mice Reviewed International journal

    Ryusuke Yoshida, Misa Shin, Keiko Yasumatsu, Shingo Takai, Mayuko Inoue, Noriatsu Shigemura, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya

    Frontiers in Physiology   8 ( OCT )   866   2017.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fphys.2017.00866

  • Peptide Signaling in Taste Transduction Reviewed

    Shingo Takai, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya

    Chemosensory Transduction: The Detection of Odors, Tastes, and Other Chemostimuli   299 - 317   2016.2

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    DOI： 10.1016/B978-0-12-801694-7.00017-2

  • The function of glucagon-like peptide-1 in the mouse peripheral taste system Reviewed

    Shingo Takai, Ryusuke Yoshida, Keiko Yasumatsu, Noriatsu Shigemura, Yuzo Ninomiya

    Journal of Oral Biosciences   58 ( 1 )   10 - 15   2016.2

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    DOI： 10.1016/j.job.2015.09.002

  • Glucagon-like peptide-1 is specifically involved in sweet taste transmission Reviewed

    Shingo Takai, Keiko Yasumatsu, Mayuko Inoue, Shusuke Iwata, Ryusuke Yoshida, Noriatsu Shigemura, Yuchio Yanagawa, Daniel J. Drucker, Robert F. Margolskee, Yuzo Ninomiya

    FASEB Journal   29 ( 6 )   2268 - 2280   2015.6

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    Language：Others   Publishing type：Research paper (scientific journal)  

    DOI： 10.1096/fj.14-265355

  • 味神経に発現するGLP-1レセプターとその役割 Reviewed

    髙井 信吾, 中野 (安松) 啓子, 吉田 竜介, 重村 憲徳, 二ノ宮 裕三

    日本味と匂学会誌第21巻3号   2015.2

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  • Umami taste in mice uses multiple receptors and transduction pathways Reviewed

    Keiko Yasumatsu, Yoko Ogiwara, Shingo Takai, Ryusuke Yoshida, Ken Iwatsuki, Kunio Torii, Robert F. Margolskee, Yuzo Ninomiya

    Journal of Physiology   590 ( 5 )   1155 - 1170   2012.2

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    Language：Others   Publishing type：Research paper (scientific journal)  

    DOI： 10.1113/jphysiol.2011.211920

  • Responses to apical and basolateral application of glutamate in mouse fungiform taste cells with action potentials. Reviewed

    Mayu Niki, Shingo Takai, Yoko Kusuhara, Yuzo Ninomiya, Ryusuke Yoshida

    Cellular and molecular neurobiology   31 ( 7 )   1033 - 1040   2011.10

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    Language：Others   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10571-011-9702-5

  • Gustatory signaling in the periphery Detection, transmission, and modulation of taste information Reviewed

    Mayu Niki, Ryusuke Yoshida, Shingo Takai, Yuzo Ninomiya

    Biological and Pharmaceutical Bulletin   33 ( 11 )   1772 - 1777   2010.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1248/bpb.33.1772

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Books

  • CHEMOSENSORY TRANSDUCTION: DETECTION OF ODOR, TASTE AND OTHER CHEMOSTIMULI

    Takai Shingo, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya（ Role： Joint author）

    Elsevier  2016.3 

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    Responsible for pages：Chapter 17: Peptide signaling in taste transduction edited by Frank Zufall and Steven D. Munger   Language：English   Book type：Scholarly book

Presentations

  • 2P-083　「マウスにおけるGPRC5Cの発現とリガンドの探索」

    髙井　信吾、川端　由子、實松　敬介、岩田　周介、川端　二功、兼松　隆、自見　英治郎、重村　憲徳

    第101回日本生理学会大会  2024.3 

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    Event date： 2024.4

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    Venue：小倉   Country：Japan  

  • P3-3-02　「GPRC5ファミリーによる糖受容機構の探索」

    髙井　信吾、川端　由子、實松　敬介、岩田　周介、兼松　隆、自見　英治郎、重村　憲徳

    第65回歯科基礎医学会学術大会  2023.9 

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    Event date： 2024.4

    Language：English  

    Venue：東京   Country：Japan  

  • B-16　「GPRC5 familyの発現と機能の探索」

    髙井　信吾、川端　由子、實松　敬介、岩田　周介、川端　二功、重村　憲徳

    日本味と匂学会 第57回大会  2023.9 

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    Event date： 2024.4

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    Country：Japan  

  • P-14　mTORシグナリングを介した味蕾の体内栄養感知機構

    髙井　信吾、岩田　周介、實松　敬介、大野　友里花、重村　憲徳

    日本味と匂学会 第56回大会  2022.8 

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    Event date： 2023.6

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    Venue：仙台   Country：Japan  

  • CNP-NPRB signaling modulates the peripheral salt taste sensitivity in mice International conference

    Yuka Sugawara, Shingo Takai, Syusuke Iwata, Yuko Kawabata, Keisuke Sanematsu, Noriatsu Shigemura

    The 19th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  2023.3 

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    Event date： 2023.3

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    Country：Japan  

  • P-57　Mechanistic target of rapamycin (mTOR) expression in mouse taste bud cells

    髙井　信吾、岩田　周介、實松　敬介、重村　憲徳

    日本味と匂学会第55回大会  2021.9 

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    Event date： 2022.6

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    Venue：福岡   Country：Japan  

  • 2-P1-P33　体内の栄養状態を反映したマウス味細胞のmechanistic target of rapamycin（mTOR）活性化

    髙井　信吾、岩田　周介、實松　敬介、重村　憲徳

    第63回歯科基礎医学会学術大会  2021.10 

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    Event date： 2022.6

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  • ISP13 Insulin - mTOR signaling regulate taste bud organoid growth

    Shingo Takai, Robert F. Margolskee, Peihua Jiang, Yuzo Ninomiya, Noriatsu Shigemura

    The 18th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  2019.11 

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    Event date： 2020.1

    Language：Japanese  

    Country：Japan  

  • MS2-2 味細胞オルガノイドを用いた味細胞分化/増殖に影響を及ぼす因子の探索 Invited

    髙井 信吾，Robert F. Margolskee，Peihua Jiang，二ノ宮裕三，重村 憲徳

    第61回歯科基礎医学会学術大会 メインシンポジウム2 「味覚の新たな方向性」  2019.10 

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    Event date： 2019.10

    Language：Japanese  

    Venue：東京   Country：Japan  

  • P-21 マウス味細胞におけるmechanistic target of rapamycin (mTOR)の働き

    髙井　信吾、Robert F. Margolskee、Peihua Jiang、二ノ宮　裕三、重村　憲徳

    日本味と匂学会第53回大会  2019.9 

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    Event date： 2019.9

    Language：Japanese  

    Venue：高知   Country：Japan  

  • The effects of insulin signaling on mouse taste bud organoid International conference

    Shingo Takai, Peihua Jiang, Robert F Margolskee, Yuzo Ninomiya, Noriatsu Shigemura

    the 9th Federation of the Asian and Oceanian Physiological Societies Congress  2019.3 

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    Event date： 2019.6

    Language：English  

    Country：Japan  

  • The function of insulin and insulinotropic peptides in taste tissue Invited International conference

    The 3rd Symposium program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers  2017.2 

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    Event date： 2019.6

    Language：English  

    Country：Japan  

  • インスリンシグナルは味細胞の分化・増殖に関与する Invited

    髙井　信吾、Margolskee RF、Jiang P、二ノ宮　裕三、重村　憲徳

    第60回歯科基礎医学会学術大会 アップデートシンポジウム4 「若手の口腔生理学研究最前線」  2018.9 

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    Event date： 2019.6

    Language：Japanese  

    Country：Japan  

  • The potential effects of insulin signaling on mouse taste bud organoid International conference

    Shingo Takai, Robert F. Margolskee, Peihua Jiang, Yuzo Ninomiya, Noriatsu Shigemura

    The 17th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  2018.11 

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    Event date： 2019.6

    Language：English  

    Country：Japan  

  • マウス味細胞の分化・増殖におけるインスリンの効果

    髙井　信吾、Robert F. Margolskee、Peihua Jiang、二ノ宮　裕三、重村　憲徳

    日本味と匂学会第　52回大会  2018.10 

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    Event date： 2018.10 - 2019.6

    Language：Japanese  

    Country：Japan  

  • The insulin signaling could promote taste cell proliferation International conference

    Shingo Takai, Noriatsu Shigemura, Robert F. Margolskee, Yuzo Ninomiya

    The 16th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  2017.11 

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    Event date： 2018.7

    Language：English  

    Country：Japan  

  • 味細胞オルガノイドの増殖・分化に対するインスリンの効果

    髙井信吾、二ノ宮裕三、重村憲徳

    日本味と匂学会　第51回大会  2017.9 

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    Event date： 2018.7

    Language：Japanese  

    Country：Japan  

  • マウス味覚器に発現するインスリンレセプターは味細胞の増殖・分化に関与する

    髙井信吾、二ノ宮裕三、重村憲徳

    第59回歯科基礎医学会学術大会  2017.7 

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    Event date： 2017.9

    Language：Japanese  

    Venue：松本   Country：Japan  

  • マウス味細胞におけるglucose-dependent insulinotropic polypeptide receptor (GIPR)の発現

    髙井 信吾, 二ノ宮 裕三, 重村 憲徳

    第58回歯科基礎医学会学術大会  2016.8 

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    Event date： 2017.5

    Language：Japanese  

    Venue：札幌   Country：Japan  

  • 2P-071 The expression of glucose-dependent insulinotropic polypeptide receptor (GIPR) and　insulin receptor (IR) in mouse taste cells

    第94回日本生理学会大会  2017.3 

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    Event date： 2017.3

    Language：English  

    Venue：浜松   Country：Japan  

  • Glucagon like peptide-1, sweet taste and metabolic modulation of peripheral taste information Invited International conference

    17th International Symposium on Olfaction and Taste (ISOT2016)  2016.7 

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    Event date： 2016.7

    Language：English  

    Country：Japan  

  • Glucagon like peptide-1 (GLP-1) underlies sweet taste transmission Invited

    Takai Shingo, Keiko Nakano (Yasumatsu), Shusuke Iwata, Mayuko Inoue, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya

    2014.10 

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    Event date： 2014.10

    Language：English  

    Country：Japan  

  • 味蕾から分泌されるGLP-1は甘味特異的な情報伝達に関与する Invited

    髙井 信吾

    第56回歯科基礎医学会学術大会･総会 サテライトシンポジウム 「若手の口腔生理学研究最前線」  2014.9 

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    Event date： 2014.9

    Language：Japanese  

    Venue：福岡   Country：Japan  

  • GLP-1 may be involved in sweet specific taste transmission from taste cells to gustatory nerve fibers Invited

    Takai S, Yasumatsu K, Iwata S, Inoue M, Yoshida R, Shigemura N, Margolskee RF, Drucker DJ, Ninomiya Y

    2014.3 

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    Event date： 2014.3

    Language：English  

    Country：Japan  

  • 味蕾から分泌されるGLP-1は甘味特異的な情報伝達に関与する

    髙井　信吾、安松　啓子、井上　真由子、岩田　周介、吉田　竜介、重村　憲徳、二ノ宮　裕三

    第4回福岡薬理・生理系研究会  2013.12 

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    Event date： 2013.12

    Language：Japanese  

    Venue：福岡  

  • GLP-1 may be involved in sweet specific taste transmission from taste cells to gustatory nerve fibers Invited International conference

    Takai S, Yasumatsu K, Iwata S, Inoue M, Yoshida R, Shigemura N, Ninomiya Y

    The 11th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  2013.11 

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    Event date： 2013.11

    Language：English  

    Country：Japan  

  • P-023 The secretion of GLP-1 from mice taste bud in response to sweet taste stimuli

    Takai S, Yasumatsu K, Niki M, Iwata S, Yoshida R, Shigemura N, Ninomiya Y

    2013.9 

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    Event date： 2013.9

    Language：Japanese  

    Country：Japan  

  • P2-128 マウス味蕾におけるインスリン分泌ホルモンの発現

    髙井　信吾、仁木　麻由、吉田　竜介、重村　憲徳、二ノ宮　裕三

    第54回歯科基礎医学会学術大会･総会  2012.9 

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    Language：Japanese  

    Venue：福島   Country：Japan  

  • P-030 An electrophysiological analysis of responses to apical and basolateral application of glutamate in mouse taste cells

    Takai S, Niki M, Kusuhara Y, Yoshida R, Ninomiya Y

    2012.10 

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    Country：Japan  

  • P1-56 マウス味蕾における甘味特異的なGLP-1の分泌

    髙井　信吾、安松　啓子、吉田　竜介、重村　憲徳、二ノ宮　裕三

    第55回歯科基礎医学会学術大会･総会  2013.9 

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    Language：Japanese  

    Venue：岡山   Country：Japan  

  • #175 Insulin-mTOR signaling may regulate mouse taste cell generation International conference

    Shingo Takai, Yu Watanabe, Robert F. Margolskee, Peihua Jiang, Yuzo Ninomiya, Noriatsu Shigemura

    18th International Symposium on Olfaction and Taste (ISOT2020)  2020.8 

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    Language：English  

  • MS1-2 オルガノイド培養系を用いた味細胞分化メカニズム解明への新たなアプローチ Invited

    髙井　信吾、渡邊　雄、Robert F. Margolskee、Peihua Jiang、二ノ宮　裕三、重村　憲徳

    第62回　歯科基礎医学会学術大会 メインシンポジウム3 「発生から再生への挑戦」  2020.10 

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    Language：Japanese  

    Venue：web開催   Country：Japan  

  • 3-PG5　「味蕾の基底細胞はmTORシグナリングを介して体内栄養状態をモニターする」

    高井 信吾, 岩田 周介, 實松 敬介, 川端 由子, 平山 彩夏, 渡邉 雄, 重村 憲徳

    第64回歯科基礎医学会学術大会  2022.9 

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    Language：Japanese  

    Country：Japan  

  • P3-3-02　「GPRC5ファミリーによる糖受容機構の探索」

    髙井　信吾、川端　由子、實松　敬介、岩田　周介、兼松　隆、自見　英治郎、重村　憲徳

    第65回歯科基礎医学会学術大会  2023.9 

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    Language：Japanese  

    Venue：東京   Country：Japan  

  • B-16　「GPRC5 familyの発現と機能の探索」

    髙井　信吾、川端　由子、實松　敬介、岩田　周介、川端　二功、重村　憲徳

    日本味と匂学会 第57回大会  2023.9 

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    Language：Japanese  

    Venue：東京   Country：Japan  

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MISC

  • Glucagon like peptide-1, sweet taste and metabolic modulation of peripheral taste information

    Shingo Takai, Noriatsu Shigemura, Keiko Yasumatsu-Nakano, Mayuko Inoue, Shusuke Iwata, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

    CHEMICAL SENSES   2016.11

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    Language：English  

  • 味覚と健康 栄養素センサー研究の現状と未来 味覚受容体の機能(塩味と甘味)

    重村 憲徳, 吉田 竜介, 安松 啓子, 大栗 弾宏, 岩田 周介, 高井 信吾, 上瀧 将史, 仁木 麻由, 實松 敬介, 二ノ宮 祐三

    日本薬学会年会要旨集   2016.3

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    Language：Japanese  

  • ホルモンによる味覚(塩味・甘味)感受性調節

    重村 憲徳, 吉田 竜介, 安松 啓子, 大栗 弾宏, 岩田 周介, 高井 信吾, 上瀧 将史, 仁木 麻由, 實松 敬介, 二ノ宮 裕三

    日本生物工学会大会講演要旨集   2015.9

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    Language：Japanese  

  • Involvement of CCK in normal gustatory responses to bitter compounds

    Misa Shin, Keiko Yasumatsu, Shingo Takai, Noriatsu Shigemura, Ryusuke Yoshida, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya

    CHEMICAL SENSES   2015.3

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    Language：English  

  • 【香辛料の味修飾作用及び消化管を介した代謝調節作用】ホルモンによる味覚修飾と摂食調節 アンジオテンシンIIと味覚

    重村 憲徳, 吉田 竜介, 安松 啓子, 大栗 弾宏, 岩田 周介, 高井 信吾, 上瀧 将史, 仁木 麻由, 實松 敬介, 二ノ宮 裕三

    日本味と匂学会誌   2014.4

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    Language：Japanese  

    アンジオテンシンIIは、視床下部、副腎や血管などに発現するAT1受容体を介して、血圧や体内Na+濃度を調節する鍵ホルモンとして知られている。我々は、このアンジオテンシンIIが末梢の味覚器にも働き、塩味感受性を低下させNaCl溶液の摂取量を増加させること、さらに甘味感受性を増強することで糖分摂取にも影響することを明らかにした。この"味覚を介したNa+/糖ホメオスタシス維持機構"のさらなる解明は、高血圧や肥満・糖尿病などの生活習慣病に対する新たな予防・治療法の開発"に繋がることが期待される。(著者抄録)

    DOI： 10.18965/tasteandsmell.21.1_49

Professional Memberships

  • The Japanese Association for the Study of Taste and Smell

  • 日本生理学会

  • Japanese Association for Oral Biology

  • JAPANESE ASSOCIATION FOR ORAL BIOLOGY

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  • THE PHYSIOLOGICAL SOCIETY OF JAPAN

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  • THE JAPANESE ASSOCIATION FOR THE STUDY OF TASTE AND SMELL

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Academic Activities

  • Yonsei University Session　座長 International contribution

    （ 九州大学 ） 2024.2

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship） International contribution

    Kyudai Oral Bioscience (KOB) 2014 Session 2: PhD Student Session　Chairperson (with Xinwen Zhang)  （ 福岡リーセントホテル ） 2014.2 - 2014.3

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    Type：Competition, symposium, etc. 

Research Projects

  • Establishment of regulatory basis for nutrition and biological defense using taste receptors

    Grant number：24K02883  2024.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant type：Scientific research funding

    CiNii Research

  • 健診Big Dataを基盤とした味覚健康医療の創発

    Grant number：22K19672  2022.6 - 2025.3

    科学研究費助成事業  挑戦的研究(萌芽)

    重村 憲徳, 實松 敬介, 高井 信吾, 岩田 周介

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    Grant type：Scientific research funding

    味覚の異常は、口腔のみならず全身の臓器でも生じ、摂食嚥下障害や生活習慣病の発症原因となる可能性が示唆されている。しかし、この味覚異常発症の分子機構はほとんど不明である。そこで本研究では、この「真の原因」を明らかにするために大規模健診における味覚検査データと、それと紐付けされた約2000項目の健康Big Dataとの多元的な相関解析を行うことにより味覚異常の原因因子を追求することに挑戦する。

    CiNii Research

  • Sensing mechanism for internal nutritional state in the peripheral taste tissue

    Grant number：22K09915  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

    CiNii Research

  • ナトリウム利尿ペプチドにより末梢塩味感受性調節機構の解明

    2022

    公益財団法人ソルト・サイエンス研究財団2022年度研究助成

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    Authorship：Principal investigator  Grant type：Contract research

  • 「新規味蕾オルガノイドを用いた味覚器の機能的・解剖学的極性獲得機構の解明」

    2021 - 2023

    公益財団法人　内藤記念科学振興財団、2020年度 内藤財団次世代育成支援研究助成金

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    Authorship：Principal investigator  Grant type：Contract research

  • 「ヒアルロン酸シグナリングに着目したがん治療に伴う味覚障害治療法の創出」

    2021 - 2022

    公益財団法人　ふくおか公衆衛生推進機構、令和2年度がん研究助成金

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    Authorship：Principal investigator  Grant type：Contract research

  • 味蕾オルガノイドを用いた味細胞極性獲得メカニズムの解明

    Grant number：20K18457  2020 - 2021

    日本学術振興会  科学研究費助成事業  若手研究

    高井 信吾

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    Authorship：Principal investigator  Grant type：Scientific research funding

    現在、様々な生活習慣病、特に肥満や糖尿病が世界的に深刻な問題となっている。これらの疾病の根本的な予防と治療には、食事を含む生活習慣への介入が不可欠であり、それには我々の摂食行動が味覚を通じてどのように形成されるかを理解する必要がある。我々の口腔内に存在する味蕾は、表面側に発現する味受容体で味物質を感知し、基底側に接続する神経にその情報を伝達することで、多様な味情報を中枢へと伝えている。この味蕾が持つ極性は、味覚器の機能を理解する上で極めて重要であるが、その形成メカニズムには不明な点が多い。本研究では、味細胞培養系である味蕾オルガノイドを手掛かりに、味細胞の極性形成メカニズムの解明を目指す。

    CiNii Research

  • ISOT2020参加・発表（コロナウイルス感染症の影響で学会が中止になったため辞退）

    2020

    令和２年度 研究活動基礎支援制度｢国際学会派遣支援｣（第１回）

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • Elucidation of molecular basis of the onset of taste disorder based on pharmaco-genomics

    Grant number：19H03818  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Shigemura Noriatsu

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    Grant type：Scientific research funding

    Taste disorders present with symptoms such as "no taste, always bitter," and significantly reduces not only quality of life but also nutritional status. However, its pathogenesis is largely unknown. The purpose of this study was to elucidate the molecular basis of taste disorders through the use of　pharmacological action of various drugs. In this study, we developed mouse models with taste disorder induced by administration of anticancer drugs, osteoporosis drug bisphosphonate, antiarrhythmic drug flecainide and antipyretic analgesic diclofenac. Using molecular biological, neurological and behavioral analyses, and taste bud organoid technology, we clarified the molecular mechanism of the onset of each taste disorders. These results would be expected to lead to the development of novel preventive and therapeutic methods for taste disorders.

    CiNii Research

  • 末梢味覚器におけるインスリンシグナルの機能の解明

    Grant number：17K17938  2017 - 2019

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 頭脳循環を加速する戦略的国際研究ネットワーク推進プログラム「口腔から健康長寿を支えるプロジェクト推進に向けた研究拠点構築プログラム」 International coauthorship

    2015.5 - 2016.4

  • 味細胞と腸管内分泌細胞に共通する甘味受容メカニズムに関する研究

    Grant number：15H06485  2015 - 2016

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • インスリン分泌ホルモンによる甘味特異的な情報伝達メカニズムの解明

    Grant number：245570  2012 - 2014

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

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    Authorship：Principal investigator  Grant type：Scientific research funding

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Educational Activities

  • In charge of Oral physiology (lecture and practical training) for the undergraduate students.
    Conducting the Early Exposure and Research Exposure programs for the undergraduate students.
    Train the graduate students in Ph. D course of dental science.

Class subject

  • リサーチエクスポージャ

    2023.4 - 2024.3   Full year

  • 口腔機能解析学（低年次）

    2023.4 - 2024.3   Full year

  • 口腔生理学

    2023.4 - 2024.3   Full year

  • 口腔機能解析学（コア）

    2023.4 - 2024.3   Full year

  • 口腔機能解析学（高年次）

    2023.4 - 2024.3   Full year

  • アーリーエクスポージャ

    2023.4 - 2023.9   First semester

  • リサーチエクスポージャ

    2022.4 - 2023.3   Full year

  • 口腔機能解析学（低年次）

    2022.4 - 2023.3   Full year

  • 口腔生理学

    2022.4 - 2023.3   Full year

  • 口腔機能解析学（コア）

    2022.4 - 2023.3   Full year

  • 口腔機能解析学（高年次）

    2022.4 - 2023.3   Full year

  • アーリーエクスポージャ

    2022.4 - 2022.9   First semester

  • 口腔機能解析学（高年次）

    2021.4 - 2022.3   Full year

  • 口腔機能解析学（コア）

    2021.4 - 2022.3   Full year

  • 口腔機能解析学（低年次）

    2021.4 - 2022.3   Full year

  • 口腔生理学

    2021.4 - 2022.3   Full year

  • リサーチエクスポージャ

    2021.4 - 2022.3   Full year

  • Oral Physiology and Taste Health Science

    2021.4 - 2022.3   Full year

  • アーリーエクスポージャ

    2021.4 - 2021.9   First semester

  • リサーチエクスポージャ

    2020.4 - 2021.3   Full year

  • 口腔機能解析学（高年次）

    2020.4 - 2021.3   Full year

  • 口腔機能解析学（コア）

    2020.4 - 2021.3   Full year

  • 口腔機能解析学（低年次）

    2020.4 - 2021.3   Full year

  • 口腔生理学

    2020.4 - 2021.3   Full year

  • アーリーエクスポージャ

    2020.4 - 2020.9   First semester

  • 口腔生理学

    2019.4 - 2020.3   Full year

  • 口腔機能解析学（低年次）

    2019.4 - 2020.3   Full year

  • 口腔機能解析学（コア）

    2019.4 - 2020.3   Full year

  • 口腔機能解析学（高年次）

    2019.4 - 2020.3   Full year

  • 電気生理学実験法（大学院）

    2019.4 - 2020.3   Full year

  • 口腔機能解析学演習

    2019.4 - 2020.3   Full year

  • 口腔機能解析学

    2019.4 - 2020.3   Full year

  • リサーチエクスポージャ

    2019.4 - 2020.3   Full year

  • アーリーエクスポージャ

    2019.4 - 2019.9   First semester

  • 口腔生理学

    2018.4 - 2019.3   Full year

  • リサーチエクスポージャー

    2018.4 - 2019.3   Full year

  • 口腔生理学

    2017.4 - 2018.3   Full year

  • リサーチエクスポージャー

    2017.4 - 2018.3   Full year

  • Oral Physiology and Taste Health Science

    2017.4 - 2018.3   Full year

  • 電気生理学実験法（大学院）

    2017.4 - 2018.3   Full year

  • 口腔機能解析学演習

    2017.4 - 2018.3   Full year

  • 口腔機能解析学

    2017.4 - 2018.3   Full year

  • 歯学総論1

    2017.4 - 2017.9   First semester

  • 口腔生理学

    2016.4 - 2017.3   Full year

  • 歯学総論1

    2016.4 - 2016.9   First semester

▼display all

Other educational activity and Special note

  • 2016  Special Affairs 

Travel Abroad

  • 2015.5 - 2016.4

    Staying countory name 1：United States   Staying institution name 1：Monell Chemical Senses Center