Updated on 2024/10/15

Information

 

写真a

 
HAMAMURA KENGO
 
Organization
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Health Care and Sciences Lecturer
Title
Lecturer
Contact information
メールアドレス
Tel
0926424820
Profile
Among extracellular vesicles, exosomes are lipid bilayer vesicles from 50 to 150 nm in diameter and secreted by cells in vivo and cultured cells. Exosomes are also characterized by their presence in body fluids, such as blood and urine, and are distributed via body fluids to cells throughout the body. We are investigating the impact of exosomes on the pathogenesis and progression of pathological processes.
External link

Research Areas

  • Life Science / Pharmacology

Degree

  • Ph.D. (Pharmaceutical Sciences)

Research History

  • Kyushu University Department of Clinical Pharmacokinetics, Faculty of Pharmaceutical Sciences Lecturer

    2023.4 - Present

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  • Daiichi University, College of Pharmaceutical Sciences Lecturer

    2021.4 - 2023.3

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  • 2013年4月　日本学術振興会特別研究員（DC2） (2015年3月まで) 2015年4月　第一薬科大学 薬学部 助教 (2021年3月まで) 2021年4月　第一薬科大学 薬学部 講師 (2023年3月まで)

Research Interests・Research Keywords

  • Research theme：疼痛

    Keyword：疼痛

    Research period： 2024

  • Research theme：エクソソーム

    Keyword：エクソソーム

    Research period： 2024

  • Research theme：Novel enhancement mechanisms of the nociceptive response by serum exosomes in a mouse model of neuropathic pain

    Keyword：extracellular vesicles, exosomes, neuropathic pain, nociceptive pain

    Research period： 2015.4

  • Research theme：The potential of bergamot essential oil as a medicinal plant

    Keyword：Bergamot Essential Oil

    Research period： 2015.4

  • Research theme：Novel Mechanism of Renal Function Deterioration via Kidney-Liver-Kidney Linkage of Molecular Clock Mechanism in a Mouse Model of Chronic Kidney Disease

    Keyword：Chronic Kidney Disease

    Research period： 2009.4

Awards

  • 優秀発表賞

    2014.11   第8回次世代を担う若手医療薬科学シンポジウム   慢性腎臓病モデルマウスにおける分子時計機構の腎-肝-腎連関を介した新規腎機能悪化機序 の解明

  • 優秀ポスター賞

    2014.11   第21回日本時間生物学会学術大会   慢性腎不全モデルマウスにおける肝代謝酵素発現日内変動変容機構の解明

Papers

  • Hericenone C attenuates the second phase of formalin-induced nociceptive behavior by suppressing the accumulation of CD11c-positive cells in the paw epidermis via phosphorylated P65 Reviewed

    Junhao Li, Kengo Hamamura, Yuya Yoshida, Shimpei Kawano, Shohei Uchinomiya, Jiahongyi Xie, Damiana Scuteri, Kohei Fukuoka, Orion Zaitsu, Fumiaki Tsurusaki, Yuma Terada, Ryotaro Tsukamoto, Takumi Nishi, Taiki Fukuda, Kosuke Oyama, Giacinto Bagetta, Akio Ojida, Kuniyoshi Shimizu, Shigehiro Ohdo, Naoya Matsunaga

    Biochemical and Biophysical Research Communications   720   150077   2024.8   （ ISSN:0006291X ）

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    DOI： 10.1016/j.bbrc.2024.150077

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  • Circadian rhythms in CYP2A5 expression underlie the time-dependent effect of tegafur on breast cancer Reviewed

    Yuya Yoshida, Taiki Fukuda, Tomohito Tanihara, Naoki Nishikawa, Serina Iwasa, Satoka Adachi, Orion Zaitsu, Yuma Terada, Ryotaro Tsukamoto, Hideki Shimoshikiryo, Kohei Fukuoka, Fumiaki Tsurusaki, Kengo Hamamura, Kosuke Oyama, Akito Tsuruta, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo

    Biochemical and Biophysical Research Communications   708   149813 - 149813   2024.5   （ ISSN:0006-291X eISSN:1090-2104 ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bbrc.2024.149813

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  • Hematopoietic Prostaglandin D Synthase Is Increased in Mast Cells and Pericytes in Autopsy Myocardial Specimens from Patients with Duchenne Muscular Dystrophy Reviewed

    Kengo Hamamura, Yuya Yoshida, Kosuke Oyama, Junhao Li, Shimpei Kawano, Kimiko Inoue, Keiko Toyooka, Misaki Yamadera, Naoya Matsunaga, Tsuyoshi Matsumura, Kosuke Aritake

    International Journal of Molecular Sciences   25 ( 3 )   2024.2   （ ISSN:1661-6596 eISSN:1422-0067 ）

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    DOI： 10.3390/ijms25031846

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  • Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior Reviewed

    Yuya Tsurudome, Yuya Yoshida, Kengo Hamamura, Takashi Ogino, Sai Yasukochi, Shinobu Yasuo, Ayaka Iwamoto, Tatsuya Yoshihara, Tomoaki Inazumi, Soken Tsuchiya, Toru Takeo, Naomi Nakagata, shigekazu higuchi, Yukihiko Sugimoto, Akito Tsuruta, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo

    International Journal of Molecular Sciences   25 ( 3 )   2024.2   （ ISSN:1661-6596 eISSN:1422-0067 ）

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    DOI： 10.3390/ijms25031841

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  • Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment. Reviewed International journal

    Yuya Yoshida, Kohei Fukuoka, Miyu Sakugawa, Masayuki Kurogi, Kengo Hamamura, Keika Hamasaki, Fumiaki Tsurusaki, Kurumi Sotono, Takumi Nishi, Taiki Fukuda, Taisei Kumamoto, Kosuke Oyama, Takashi Ogino, Akito Tsuruta, Kouta Mayanagi, Tomohiro Yamashita, Hiroyuki Fuchino, Nobuo Kawahara, Kayo Yoshimatsu, Hitomi Kawakami, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo

    Translational research : the journal of laboratory and clinical medicine   269   31 - 46   2024.2   （ ISSN:1931-5244 eISSN:1878-1810 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    Chronic kidney disease (CKD) induces cardiac inflammation and fibrosis and reduces survival. We previously demonstrated that G protein-coupled receptor 68 (GPR68) promotes cardiac inflammation and fibrosis in mice with 5/6 nephrectomy (5/6Nx) and patients with CKD. However, no method of GPR68 inhibition has been found that has potential for therapeutic application. Here, we report that Cephalotaxus harringtonia var. nana extract and homoharringtonine ameliorate cardiac inflammation and fibrosis under CKD by suppressing GPR68 function. Reagents that inhibit the function of GPR68 were explored by high-throughput screening using a medicinal plant extract library (8,008 species), and we identified an extract from Cephalotaxus harringtonia var. nana as a GPR68 inhibitor that suppresses inflammatory cytokine production in a GPR68 expression-dependent manner. Consumption of the extract inhibited inflammatory cytokine expression and cardiac fibrosis and improved the decreased survival attributable to 5/6Nx. Additionally, homoharringtonine, a cephalotaxane compound characteristic of C. harringtonia, inhibited inflammatory cytokine production. Homoharringtonine administration in drinking water alleviated cardiac fibrosis and improved heart failure and survival in 5/6Nx mice. A previously unknown effect of C. harringtonia extract and homoharringtonine was revealed in which GPR68-dependent inflammation and cardiac dysfunction were suppressed. Utilizing these compounds could represent a new strategy for treating GPR68-associated diseases, including CKD.

    DOI： 10.1016/j.trsl.2024.02.004

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  • Time-dependent differences in vancomycin sensitivity of macrophages underlie vancomycin-induced acute kidney injury Reviewed International journal

    Yuya Yoshida, Taiki Fukuda, Kohei Fukuoka, Toshitaka Nagayama, Tomohito Tanihara, Naoki Nishikawa, Kaita Otsuki, Yuma Terada, Kengo Hamamura, Kosuke Oyama, Akito Tsuruta, Kota Mayanagi, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo

    Journal of Pharmacology and Experimental Therapeutics   388 ( 1 )   JPET - AR   2023.11   （ ISSN:0022-3565 eISSN:1521-0103 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Society for Pharmacology & Experimental Therapeutics (ASPET)  

    Although vancomycin (VCM)-frequently used to treat drug-resistant bacterial infections-often induces acute kidney injury (AKI), discontinuation of the drug is the only effective treatment; therefore, analysis of effective avoidance methods is urgently needed. Here, we report the differences in the induction of AKI by VCM in 1/2-nephrectomized mice depending on the time of administration. Despite the lack of difference in the accumulation of VCM in the kidney between the light (ZT2) and dark (ZT14) phases, the expression of AKI markers due to VCM was observed only in the ZT2 treatment. Genomic analysis of the kidney suggested that the time of administration was involved in VCM-induced changes in monocyte and macrophage activity, and VCM had time-dependent effects on renal macrophage abundance, ATP activity, and interleukin (IL)-1β expression. Furthermore, the depletion of macrophages with clodronate abolished the induction of IL-1β and AKI marker expression by VCM administration at ZT2. This study provides evidence of the need for time-dependent pharmacodynamic considerations in the prevention of VCM-induced AKI as well as the potential for macrophage-targeted AKI therapy. SIGNIFICANCE STATEMENT: There is a time of administration at which vancomycin (VCM)-induced renal injury is more and less likely to occur, and macrophages are involved in this difference. Therefore, there is a need for time-dependent pharmacodynamic considerations in the prevention of VCM-induced acute kidney injury as well as the potential for macrophage-targeted acute kidney injury therapy.

    DOI： 10.1124/jpet.123.001864

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  • Oral administration of vancomycin alleviates heart failure triggered by chronic kidney disease Reviewed

    Kohei Fukuoka, Yuya Yoshida, Kurumi Sotono, Naoki Nishikawa, Kengo Hamamura, Kosuke Oyama, Akito Tsuruta, Kota Mayanagi, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo

    Biochemical and Biophysical Research Communications   675   92 - 98   2023.10   （ ISSN:0006-291X eISSN:1090-2104 ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bbrc.2023.07.015

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  • Efficacy of Essential Oils in Relieving Cancer Pain: A Systematic Review and Meta-Analysis Reviewed

    Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone, Paolo Tonin, Kengo Hamamura, Takafumi Hayashi, Francesca Guida, Sabatino Maione, Damiana Scuteri

    International Journal of Molecular Sciences   24 ( 8 )   7085 - 7085   2023.4   （ ISSN:1661-6596 eISSN:1422-0067 ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Over 80% of patients affected by cancer develops cancer-related pain, one of the most feared consequences because of its intractable nature, particularly in the terminal stage of the disease. Recent evidence-based recommendations on integrative medicine for the management of cancer pain underline the role of natural products. The present systematic review and meta-analysis aims at appraising for the first time the efficacy of aromatherapy in cancer pain in clinical studies with different design according to the most updated Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 recommendations. The search retrieves 1002 total records. Twelve studies are included and six are eligible for meta-analysis. The present study demonstrates significant efficacy of the use of essential oils in the reduction of the intensity of pain associated with cancer (p < 0.00001), highlighting the need for earlier, more homogeneous, and appropriately designed clinical trials. Good certainty body of evidence is needed for effective and safe management of cancer-related pain using essential oils by establishment of a step-by-step preclinical-to-clinical pathway to provide a rational basis for clinical use in integrative oncology. PROSPERO registration: CRD42023393182.

    DOI： 10.3390/ijms24087085

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  • Analgesic Characteristics of NanoBEO Released by an Airless Dispenser for the Control of Agitation in Severe Dementia Reviewed International journal

    Damiana Scuteri, Laura Rombolà, Takafumi Hayashi, Chizuko Watanabe, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Paolo Tonin, Giacinto Bagetta, Luigi A. Morrone, Maria Tiziana Corasaniti

    Molecules   27 ( 15 )   2022.8

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    Chronic pain is one of the most common causes of the need for clinical evaluation, acquiring more importance in the elderly with cognitive impairment. Reduced self-reporting capabilities cause unrelieved pain contributing to the development of agitation. Safe and effective pain treatment can afford the management of agitation without the serious increase in death risk associated with neuroleptics. To this aim, the essential oil of bergamot (BEO), proven by rigorous evidence to have strong preclinical anti-nociceptive and anti-allodynic properties, has been engineered (NanoBEO, patent EP 4003294) to allow randomized, double-blind, placebo-controlled trials (BRAINAID, NCT04321889). The present study: (1) assesses the analgesic effects of a single therapeutic dose of NanoBEO, as supplied by an airless dispenser for clinical translation, in models of inflammatory, neuropathic, and sensitization types of pain relevant to clinic; (2) provides a dose-response analysis of the efficacy of NanoBEO on scratching behavior, a typical behavioral disturbance occurring in dementia. A single therapeutic dose of NanoBEO confirms efficacy following thirty minutes pre-treatment with capsaicin and on the central sensitization phase induced by formalin. Moreover, it has an ID50 of 0.6312 mg and it is efficacious on static and dynamic mechanical allodynia. Altogether, the gathered results strengthen the potential of NanoBEO for clinical management of pain and agitation.

    DOI： 10.3390/molecules27154987

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  • Transgenic Mice for the Translational Study of Neuropathic Pain and Dystonia. Reviewed International journal

    Damiana Scuteri, Kengo Hamamura, Chizuko Watanabe, Paolo Tonin, Giacinto Bagetta, Maria Tiziana Corasaniti

    International journal of molecular sciences   23 ( 15 )   2022.8   （ ISSN:16616596 ）

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    Murine models are fundamental in the study of clinical conditions and the development of new drugs and treatments. Transgenic technology has started to offer advantages in oncology, encompassing all research fields related to the study of painful syndromes. Knockout mice or mice overexpressing genes encoding for proteins linked to pain development and maintenance can be produced and pain models can be applied to transgenic mice to model the most disabling neurological conditions. Due to the association of movement disorders with sensitivity and pain processing, our group focused for the first time on the role of the torsinA gene GAG deletion-responsible for DYT1 dystonia-in baseline sensitivity and neuropathic responses. The aim of the present report are to review the complex network that exists between the chaperonine-like protein torsinA and the baseline sensitivity pattern-which are fundamental in neuropathic pain-and to point at its possible role in neurodegenerative diseases.

    DOI： 10.3390/ijms23158580

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  • Pharmacotechnological Advances for Clinical Translation of Essential Oils for the Treatment of Pain and Agitation in Severe Dementia Reviewed

    Damiana Scuteri, Chizuko Watanabe, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Paolo Tonin, Giacinto Bagetta, Maria Tiziana Corasaniti

    Processes   10 ( 7 )   2022.7

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    DOI： 10.3390/pr10071340

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  • Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions. Reviewed International journal

    Damiana Scuteri, Laura Rombolà, Michele Crudo, Chizuko Watanabe, Hirokazu Mizoguchi, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Luigi Antonio Morrone, Paolo Tonin, Giacinto Bagetta, Maria Tiziana Corasaniti

    Pharmaceutics   14 ( 5 )   2022.5

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    The essential oil of bergamot (BEO) has consistently proven antinociceptive and antiallodynic properties. Accordingly, the analgesic efficacy of the decolored essential oil (DEC), with higher levels of limonene, and the deterpenated (DET) fraction, with higher levels of linalool and linalyl acetate, was investigated using a formalin test after inhalation. The present study was aimed at characterizing the effects of BEO, its components with the highest pharmacological activity (represented by linalool, limonene, and linalyl acetate), and its DEC and DET fractions on the formalin test after transdermal administration relevant to clinical translation through topical application. To this aim, the schedule of intervention involved administration immediately after formalin injection or as a 5 min pretreatment followed by washout in ddY-strain mice. This study demonstrates, for the first time, the significant analgesic effect of all three constituents in the first and second phases, accounting for the efficacy of the essential oil in the formalin test. While all fractions revealed equal activity toward the phytocomplex in the early phase, the reduction in time of licking/biting during the late phase was more markedly induced by DEC. Moreover, pretreatment with BEO and its fractions followed by washout did not produce a significant reduction in licking/biting time in both phases of formalin-induced nociceptive response.

    DOI： 10.3390/pharmaceutics14051006

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  • Is there a rational basis for cannabinoids research and development in ocular pain therapy? A systematic review of preclinical evidence Reviewed

    Scuteri D., Rombolà L., Hamamura K., Sakurada T., Watanabe C., Sakurada S., Guida F., Boccella S., Maione S., Gallo Afflitto G., Nucci C., Tonin P., Bagetta G., Corasaniti M.T.

    Biomedicine and Pharmacotherapy   146   2022.2   （ ISSN:07533322 ）

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    Publisher：Biomedicine and Pharmacotherapy  

    Background: Purpose of the present systematic review is to investigate preclinical evidence in favor of the working hypothesis of efficacy of cannabinoids in ocular pain treatment. Methods: Literature search includes the most relevant repositories for medical scientific literature from inception until November, 24 2021. Data collection and selection of retrieved records adhere to PRISMA criteria. Results: In agreement with a priori established protocol the search retrieved 2471 records leaving 479 results after duplicates removal. Eleven records result from title and abstract screening to meet the inclusion criteria; only 4 results are eligible for inclusion in the qualitative synthesis impeding meta-analysis. The qualitative analysis highlights the antinociceptive and anti-inflammatory efficacy of Δ8-tetrahydrocannabinol, cannabidiol and its derivative HU-308 and of new racemic CB1 allosteric ligand GAT211 and its enantiomers GAT228 and GAT229. Moreover, CB2R agonists RO6871304 and RO6871085 and CB2R ligand HU910 provide evidence of anti-inflammatory efficacy. CB2 agonist HU308 reduces of 241% uveitis-induced leukocyte adhesion and changes lipidome profile. Methodological and design issues raise concern of risk of bias and the amount of studies is too small for generalization. Furthermore, the ocular pain model used can resemble only inflammatory but not neuropathic pain. Conclusions: The role of the endocannabinoid system in ocular pain is underinvestigated, since only two studies assessing the effects of cannabinoid receptors modulators on pain behavior and other two on pain-related inflammatory processes are found. Preclinical studies investigating the efficacy of cannabinoids in ocular inflammatory and neuropathic pain models are needed to pave the way for clinical translation.

    DOI： 10.1016/j.biopha.2021.112505

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  • Preclinical Characterization of Antinociceptive Effect of Bergamot Essential Oil and of Its Fractions for Rational Translation in Complementary Therapy. Reviewed International journal

    Damiana Scuteri, Laura Rombolà, Michele Crudo, Chizuko Watanabe, Hirokazu Mizoguchi, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Paolo Tonin, Maria Tiziana Corasaniti, Giacinto Bagetta

    Pharmaceutics   14 ( 2 )   2022.1

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    Bergamot essential oil (BEO) is endowed with consistent and reproducible antinociceptive and anti-allodynic properties when administered via an inhalation route. However, the effects of its main constituents and of its decolored (DEC) and deterpenated (DET) fractions, which are enriched in limonene or in linalool and linalyl acetate, respectively, on spontaneous motor activity related to anxiety and on formalin-induced licking/biting biphasic behavior have never been investigated before. Therefore, the present research aims to characterize the role of BEO components on an experimental pain model that is relevant to clinical translation. Under our present experimental conditions, a paper filter disc soaked with different volumes of the phytocomplex and of its fractions that was applied at the edge of the observation chamber allowed the effects on the spontaneous motor activity and on the formalin-induced nocifensive response in ddY-strain mice to be studied. The present research demonstrated the effects of the DEC fraction of BEO on motor activity and on formalin-induced licking/biting behavior for the first time, proving that limonene is implicated in reduced motor activity and that it is important for the analgesic effect.

    DOI： 10.3390/pharmaceutics14020312

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  • Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis Reviewed International journal

    Yuya Yoshida, Naoya Matsunaga, Takaharu Nakao, Kengo Hamamura, Hideaki Kondo, Tomomi Ide, Hiroyuki Tsutsui, Akito Tsuruta, Masayuki Kurogi, Michio Nakaya, Hitoshi Kurose, Satoru Koyanagi, Shigehiro Ohdo

    Nature Communications   12 ( 1 )   2783 - 2783   2021.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41467-021-23050-x

  • Efficacy of Essential Oils in Pain: A Systematic Review and Meta-Analysis of Preclinical Evidence. Reviewed International journal

    Frontiers in pharmacology   12   640128 - 640128   2021.12

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    DOI： 10.3389/fphar.2021.640128

  • Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design. Reviewed International journal

    Hidetomo Yokoo, Norihito Shibata, Akinori Endo, Takahito Ito, Yuta Yanase, Yuki Murakami, Kiyonaga Fujii, Kengo Hamamura, Yasushi Saeki, Mikihiko Naito, Kosuke Aritake, Yosuke Demizu

    Journal of medicinal chemistry   64 ( 21 )   15868 - 15882   2021.11

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    DOI： 10.1021/acs.jmedchem.1c01206

  • Exploitation of Thermal Sensitivity and Hyperalgesia in a Mouse Model of Dystonia. Reviewed International journal

    Life (Basel, Switzerland)   11 ( 9 )   2021.9

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    DOI： 10.3390/life11090985

  • Development and Translation of NanoBEO, a Nanotechnology-Based Delivery System of Bergamot Essential Oil Deprived of Furocumarins, in the Control of Agitation in Severe Dementia. Reviewed International journal

    Pharmaceutics   13 ( 3 )   2021.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/pharmaceutics13030379

  • プレガバリンOD錠「ニプロ」のマウス神経障害性疼痛モデルを用いた鎮痛効果の検討 Reviewed

    濵村賢吾, 瀬頭幸子, 野口由季, 廣瀬雅美, 藤尾信行, 藤川彩香, 柳田百合香, 有竹浩介

    新薬と臨牀   69 ( 12 )   1441 - 1450   2020.12

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  • Behavioral Effects of Continuously Administered Bergamot Essential Oil on Mice With Partial Sciatic Nerve Ligation. Reviewed International journal

    Kengo Hamamura, Soh Katsuyama, Takaaki Komatsu, Damiana Scuteri, Giacinto Bagetta, Kosuke Aritake, Tsukasa Sakurada

    Frontiers in pharmacology   11   1310 - 1310   2020.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fphar.2020.01310

  • Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent. Reviewed International journal

    International journal of molecular sciences   21 ( 7 )   2020.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/ijms21072597

  • Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches. Reviewed International journal

    Naoki Kusunose, Akito Tsuruta, Kengo Hamamura, Yuya Tsurudome, Yuya Yoshida, Takahiro Akamine, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo

    Genes to cells : devoted to molecular & cellular mechanisms   25 ( 4 )   270 - 278   2020.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/gtc.12758

  • Possible involvement of the peripheral Mu-opioid system in antinociception induced by bergamot essential oil to allodynia after peripheral nerve injury. Reviewed International journal

    Takaaki Komatsu, Soh Katsuyama, Yasuhito Uezono, Chikai Sakurada, Minoru Tsuzuki, Kengo Hamamura, Giacinto Bagetta, Shinobu Sakurada, Tsukasa Sakurada

    Neuroscience letters   686   127 - 132   2018.11

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    DOI： 10.1016/j.neulet.2018.08.053

  • Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice Reviewed International journal

    Takashi Matsunaga, Naoya Matsunaga, Naoki Kusunose, Eriko Ikeda, Hiroyuki Okazaki, Keisuke Kakimoto, Kengo Hamamura, Satoru Koyanagi, Shigehiro Ohdo

    Biochemical and Biophysical Research Communications   498 ( 1 )   86 - 91   2018.3

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    DOI： 10.1016/j.bbrc.2017.11.162

  • Administering xCT Inhibitors Based on Circadian Clock Improves Antitumor Effects Reviewed International journal

    Fumiyasu Okazaki, Naoya Matsunaga, Kengo Hamamura, Kayoko Suzuki, Takaharu Nakao, Hiroyuki Okazaki, Masahiko Kutsukake, Shiro Fukumori, Yasuhiro Tsuji, Hideto To

    CANCER RESEARCH   77 ( 23 )   6603 - 6613   2017.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1158/0008-5472.CAN-17-0720

  • The involvement of spinal release of histamine on nociceptive behaviors induced by intrathecally administered spermine Reviewed International journal

    Hirokazu Mizoguchi, Chizuko Watanabe, Takafumi Hayashi, Yoko Iwata, Hiroyuki Watanabe, Soh Katsuyama, Kengo Hamamura, Tsukasa Sakurada, Hiroshi Ohtsu, Kazuhiko Yanai, Shinobu Sakurada

    EUROPEAN JOURNAL OF PHARMACOLOGY   800   9 - 15   2017.4

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    DOI： 10.1016/j.ejphar.2017.01.031

  • Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease Reviewed International journal

    Naoya Matsunaga, Eriko Ikeda, Keisuke Kakimoto, Miyako Watanabe, Naoya Shindo, Akito Tsuruta, Hisako Ikeyama, Kengo Hamamura, Kazuhiro Higashi, Tomohiro Yamashita, Hideaki Kondo, Yuya Yoshida, Masaki Matsuda, Takashi Ogino, Kazutaka Tokushige, Kazufumi Itcho, Yoko Furuichi, Takaharu Nakao, Kaori Yasuda, Atsushi Doi, Toshiaki Amamoto, Hironori Aramaki, Makoto Tsuda, Kazuhide Inoue, Akio Ojida, Satoru Koyanagi, Shigehiro Ohdo

    EBIOMEDICINE   13   262 - 273   2016.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ebiom.2016.10.008

  • Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction Reviewed International journal

    Kengo Hamamura, Naoya Matsunaga, Eriko Ikeda, Hideaki Kondo, Hisako Ikeyama, Kazutaka Tokushige, Kazufumi Itcho, Yoko Furuichi, Yuya Yoshida, Masaki Matsuda, Kaori Yasuda, Atsushi Doi, Yoshifumi Yokota, Toshiaki Amamoto, Hironori Aramaki, Yasuhiro Irino, Satoru Koyanagi, Shigehiro Ohdo

    JOURNAL OF BIOLOGICAL CHEMISTRY   291 ( 10 )   4913 - 4927   2016.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1074/jbc.M115.696930

  • Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression Reviewed International journal

    Fumiyasu Okazaki, Naoya Matsunaga, Hiroyuki Okazaki, Hiroki Azuma, Kengo Hamamura, Akito Tsuruta, Yuya Tsurudome, Takashi Ogino, Yukinori Hara, Takuya Suzuki, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Hideto To, Hironori Aramaki, Satoru Koyanagi, Shigehiro Ohdo

    JOURNAL OF BIOLOGICAL CHEMISTRY   291 ( 13 )   7017 - 7028   2016.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1074/jbc.M115.713412

  • Mitomycin C modulates the circadian oscillation of clock gene period 2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts Reviewed International journal

    Naoki Kusunose, Naoya Matsunaga, Kenichi Kimoto, Takahiro Akamine, Kengo Hamamura, Satoru Koyanagi, Shigehiro Ohdo, Toshiaki Kubota

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   467 ( 1 )   157 - 163   2015.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2015.09.086

  • 24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is Regulated by Molecular Clocks Reviewed International journal

    Naoya Matsunaga, Kazufumi Itcho, Kengo Hamamura, Eriko Ikeda, Hisako Ikeyama, Yoko Furuichi, Miyako Watanabe, Satoru Koyanagi, Shigehiro Ohdo

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   134 ( 6 )   1636 - 1644   2014.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/jid.2014.13

  • Molecular Mechanism Regulating 24-Hour Rhythm of Dopamine D3 Receptor Expression in Mouse Ventral Striatums Reviewed International journal

    Eriko Ikeda, Naoya Matsunaga, Keisuke Kakimoto, Kengo Hamamura, Akane Hayashi, Satoru Koyanagi, Shigehiro Ohdo

    MOLECULAR PHARMACOLOGY   83 ( 5 )   959 - 967   2013.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1124/mol.112.083535

  • Time-dependent interaction between differentiated embryo chondrocyte-2 and CCAAT/enhancer-binding protein α underlies the circadian expression of CYP2D6 in serum-shocked HepG2 cells. Reviewed International journal

    81 ( 5 )   739 - 747   2012.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1124/mol.111.076406

  • Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain Reviewed International journal

    Naoki Kusunose, Satoru Koyanagi, Kengo Hamamura, Naoya Matsunaga, Miyako Yoshida, Takahiro Uchida, Makoto Tsuda, Kazuhide Inoue, Shigehiro Ohdo

    MOLECULAR PAIN   6   83 - 83   2010.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/1744-8069-6-83

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Books

  • コンパス薬理学 改訂第3版. 南江堂, 2023.

    編集／櫻田司/木皿重樹. 分担執筆／濵村 賢吾 他 (計16名).（ Role： Joint author）

    2023.11 

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    Language：Japanese   Book type：Scholarly book

  • コンパス薬理学 改訂第2版. 南江堂, 2017.

    編集／櫻田 司, 分担執筆／濵村 賢吾 他 (計10名).（ Role： Joint author）

    2017.6 

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    Language：Japanese   Book type：Scholarly book

  • 体内時計分子機構と外的要因が耐糖能日周リズムを形成する. 公益社団法人 日本薬学会 学会誌 「ファルマシア」, 2013.

    濵村 賢吾

    2015.12 

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    Language：Japanese  

Presentations

  • Identification of the Tissue Producing Increased Complement C5 on the Extracellular Vesicle Bilayer Membrane in Mice Serum with Partial Sciatic Nerve Ligation International conference

    Japan-Italy Joint Meeting 2024  2024.5 

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    Event date： 2024.5

    Language：English  

    Country：Japan  

  • GPR68を標的とした慢性腎臓病誘発性の心炎症・線維化抑制化合物の探索

    吉田 優哉、佐久川 未有、福岡 航平、外野 来海、谷原 智仁、西川 直希、鶴田 朗人、小山 浩舗、濵村 賢吾、小柳 悟、松永 直哉、大戸 茂弘

    第44回日本臨床薬理学会学術総会/第97回日本薬理学会年会  2023.12 

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    Event date： 2023.12

    Language：Japanese  

    Country：Japan  

  • 微弱電流刺激がマクロファージ貪食能に及ぼす影響の解析

    鶴崎 文彬、吉田 優哉、濵崎 景佳、谷原 智仁、橋本 優希、福田 大輝、鶴田 朗人、小山 浩舗、濵村 賢吾、小柳 悟、松永 直哉、大戸 茂弘

    第44回日本臨床薬理学会学術総会/第97回日本薬理学会年会  2023.12 

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    Event date： 2023.12

    Language：Japanese  

    Country：Japan  

  • 抗体医薬品中で最も不安定なCH2ドメインの安定化による凝集の抑制

    小山 浩舗、カアベイロ ホセ、松永 直哉、濵村 賢吾、吉田 優哉、大戸 茂弘、植田 正

    第96回日本生化学会大会  2023.10 

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    Event date： 2023.10

    Language：Japanese  

    Country：Japan  

  • ヒト膵臓がんのがん幹細胞における時計遺伝子の機能解析

    財津 織音、吉田 優哉、松尾 沙紀、小山 浩舗、濵村 賢吾、松永 直哉

    第96回日本生化学会大会  2023.10 

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    Event date： 2023.10

    Language：Japanese  

    Country：Japan  

  • 慢性腎臓病による認知機能障害を改善する治療薬の探索

    熊本 大誠、西 拓海、吉田 優哉、北川 陽也、小山 浩舗、濵村 賢吾、大戸 茂弘、松永 直哉

    第96回日本生化学会大会  2023.10 

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    Event date： 2023.10

    Language：Japanese  

    Country：Japan  

  • マクロファージおよび概日時計機構に着目したバンコマイシン性腎障害の発症機構解析

    福田 大輝、吉田 優哉、谷原 智仁、西川 直希、福岡 航平、小山 浩舗、濵村 賢吾、小柳 悟、松永 直哉、大戸 茂弘

    第96回日本生化学会大会  2023.10 

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    Event date： 2023.10

    Language：Japanese  

    Country：Japan  

  • CKD病態時の小腸リンパ組織におけるCKD関連物質の蓄積がALDH高発現樹状細胞に及ぼす影響の解析

    吉田 優哉、福岡 航平、濵村 賢吾、小柳 悟、松永 直哉、大戸 茂弘

    第96回日本生化学会大会  2023.10 

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    Event date： 2023.10

    Language：Japanese  

    Country：Japan  

  • GPR68を標的とした慢性腎臓病誘発性の心炎症・線維化抑制化合物の探索

    佐久川 未有、吉田 優哉、福岡 航平、鶴崎 文彬、西 拓海、小山 浩舗、濵村 賢吾、小柳 悟、松永 直哉、大戸 茂弘

    第96回日本生化学会大会  2023.10 

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    Event date： 2023.10

    Language：Japanese  

    Country：Japan  

  • 微弱電流刺激が時計遺伝子Period1の発現および生理機能の概日リズムに及ぼす影響の解析

    谷原 智仁、橋本 優希、鶴田 朗人、小山 浩舗、濵村 賢吾、小柳 悟、松永 直哉、大戸 茂弘

    第30回 日本時間生物学会学術大会  2023.9 

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    Event date： 2023.9

    Language：Japanese  

    Country：Japan  

  • マクロファージの概日時計機構を標的とした微弱電流刺激によるがん免疫亢進法の開発

    鶴崎 文彬、吉田 優哉、濵崎 景佳、谷原 智仁、橋本 優希、福田 大輝、鶴田 朗人、小山 浩舗、濵村 賢吾、小柳 悟、松永 直哉、大戸 茂弘

    第30回 日本時間生物学会学術大会  2023.9 

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    Event date： 2023.9

    Language：Japanese  

    Country：Japan  

  • デュシェンヌ型筋ジストロフィー患者心臓における造血器型プロスタグランジンD合成酵素の発現解析

    濵村 賢吾、井上 貴美子、豊岡 圭子、山寺 みさき、有竹 浩介、松村 剛

    第9回日本筋学会学術集会/第10回筋ジストロフィー医療研究会  2023.8 

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    Event date： 2023.8

    Language：Japanese  

    Country：Japan  

  • Novel enhancement mechanisms of the nociceptive response by serum exosomes in a mouse model of neuropathic pain International conference

    Dementia Therapeutics and Cognitive Rehabilitation  2022.11 

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    Event date： 2022.11

    Language：English  

    Country：Italy  

  • Identification of the site of production of complement C5, which is upregulated on exosomal bilayers from serum of mice with partial sciatic nerve ligation

    2022.3 

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    Event date： 2022.3

    Language：Japanese  

    Country：Japan  

  • Specific degrader of hematopoietic prostaglandin D synthase prevented the progression of dilated cardiomyopathy in Duchenne muscular dystrophy

    2022.3 

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    Event date： 2022.3

    Language：Japanese  

    Country：Japan  

  • 単球に着目した慢性腎臓病時における心臓病態悪化の新規メカニズム解明

    吉田 優哉、松永 直哉、濵村 賢吾、鶴田 朗人、小柳 悟、大戸 茂弘

    医療薬学フォーラム2021/第29回クリニカルファーマシーシンポジウム  2021.7 

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    Event date： 2021.7

    Language：Japanese  

    Country：Japan  

  • 坐骨神経部分結紮マウス血清由来のエクソソームに着目した、低濃度ホルマリン誘発性侵害刺激行動の増強作用機序解明

    池田 康一郎、濵村 賢吾、古賀 真理子、三ヶ尻 幸平、勝山 壮、小松 生明、櫻田 司、有竹 浩介

    第41回日本臨床薬理学会学術総会  2020.12 

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    Event date： 2020.12

    Language：Japanese  

    Country：Japan  

  • 坐骨神経部分結紮マウスにおけるBergamot Essential Oil (BEO) の持続皮下投与による抗アロディニア作用の行動薬理学的解析

    古賀 真理子、濵村 賢吾、池田 康一郎、三ヶ尻 幸平、勝山 壮、小松 生明、櫻田 司、有竹 浩介

    第41回日本臨床薬理学会学術総会  2020.12 

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    Event date： 2020.12

    Language：Japanese  

    Country：Japan  

  • プロスタグランジン (PG) D2情報伝達抑制によるDuchenne型筋ジストロフィー性心筋症害の進行抑制

    坂口 貴章、進藤 夢加、俣野 祥子、濵村 賢吾、有竹 浩介

    第72回日本薬理学会西南部会  2019.11 

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    Event date： 2019.11

    Language：Japanese  

    Country：Japan  

  • 神経障害性疼痛モデルマウスの血清による低濃度ホルマリン誘発侵害刺激行動の増強に、エクソソームは重要な因子である

    廣瀬 雅美、濵村 賢吾、吉岡 秀哲、勝山 壮、小松 生明、櫻田 司、有竹 浩介

    第72回日本薬理学会西南部会  2019.11 

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    Event date： 2019.11

    Language：Japanese  

    Country：Japan  

  • Behavioural effects of continuously administered Bergamot Essential Oil (BEO) in mice with partial sciatic nerve ligation International conference

    Novel Pain Therapeutics: From Basic Research to Clinical Translation and Rehabilitation  2019.10 

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    Event date： 2019.10

    Language：English  

    Country：Italy  

  • Novel aggravation mechanism of heart failure mediated by monocytes in chronic kidney disease mice

    2019.10 

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    Event date： 2019.10

    Language：Japanese  

    Country：Japan  

  • Formalin-induced nociceptive response is enhanced by serum exosomes isolated from partial sciatic nerve ligation (PSL) mice International conference

    Neuroscience 2019  2019.10 

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    Event date： 2019.10

    Language：English  

  • 神経障害性疼痛モデルマウスの血清中エクソソームは低濃度ホルマリン誘発侵害刺激行動を増強する

    濵村 賢吾、勝山 壮、小松 生明、櫻田 司、有竹 浩介

    第92回日本薬理学会年会  2019.3 

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    Event date： 2019.3

    Language：Japanese  

    Country：Japan  

  • プロスタグランジンD2情報伝達制御による筋ジストロフィー性心筋障害の進行抑制

    有竹 浩介、濵村 賢吾、俣野 祥子、進藤 夢加、永田 奈々恵、岩田 裕子、裏出 良博

    第92回日本薬理学会年会  2019.3 

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    Event date： 2019.3

    Language：Japanese  

    Country：Japan  

  • マウス血清由来のエクソソームに着目した低濃度ホルマリン誘発性侵害刺激行動の増強作用機序解明

    濵村 賢吾、勝山 壮、小松 生明、櫻田 司、有竹 浩介

    第17回次世代を担う若手ファーマ・バイオフォーラム2018  2018.9 

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    Event date： 2018.9

    Language：Japanese  

    Country：Japan  

  • Novel enhancement mechanisms of the nociceptive response by serum exosomes in a mouse model of neuropathic pain International conference

    WCP2018  2018.7 

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    Event date： 2018.7

    Language：English  

    Country：Japan  

  • マウス血清由来のエクソソームに着目した低濃度ホルマリン誘発性侵害刺激行動の増強作用機序解明

    濵村 賢吾、勝山 壮、小松 生明、櫻田 司、有竹 浩介

    第13回トランスポーター研究会年会  2018.7 

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    Event date： 2018.7

    Language：Japanese  

    Country：Japan  

  • Inhibition of prostaglandin D2 signaling prevents the progression of dilated cardiomyopathy in Duchenne muscular dystrophy International conference

    WCP2018  2018.7 

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    Event date： 2018.7

    Language：English  

    Country：Japan  

  • 神経障害性疼痛モデルマウスにおけるBergamot Essential Oil (BEO) の持続皮下投与による抗アロディニア作用の行動薬理学的解析

    藤川 彩香、濵村 賢吾、勝山 壮、中野 真由佳、瀬頭 幸子、野口 由季、藤尾 信行、柳田 百合香、小松 生明、有竹 浩介、櫻田 司

    第12回日本緩和医療薬学会  2018.5 

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    Event date： 2018.5

    Language：Japanese  

    Country：Japan  

  • 香気性化合物を含む精油であるBergamot Essential Oil (BEO) の吸入投与が神経障害性疼痛モデルマウスのアロディニアに与える影響

    藤尾 信行、濵村 賢吾、勝山 壮、中野 真由佳、瀬頭 幸子、野口 由季、藤川 彩香、柳田 百合香、小松 生明、有竹 浩介、櫻田 司

    第12回日本緩和医療薬学会  2018.5 

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    Event date： 2018.5

    Language：Japanese  

    Country：Japan  

  • シノメニンの抗侵害作用メカニズムの解明

    岡村 健正、勝山 壮、櫻田 誓、高野 文秀、田畠 健治、濵村 賢吾、小川 鶴洋、小松 生明、櫻田 司

    第34回日本薬学会九州支部大会  2017.12 

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    Event date： 2017.12

    Language：Japanese  

    Country：Japan  

  • Bergamot Essential Oil (BEO) の持続皮下投与による神経障害性疼痛モデルマウスの行動薬理学的解析

    濵村 賢吾、勝山 壮、有竹 浩介、小松 生明、櫻田 司

    第70回日本薬理学会西南部会  2017.11 

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    Event date： 2017.11

    Language：Japanese  

    Country：Japan  

  • 慢性腎臓病時の炎症概日リズムに基づく新規治療薬の開発

    松永 直哉、鶴田 朗人、吉田 優哉、中尾 崇治、高露 恵理子、濵村 賢吾、渡邉 美弥子、近藤 英明、小柳 悟、大戸 茂弘

    第11回日本腎臓病薬物療法学会学術集会  2017.10 

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    Event date： 2017.10

    Language：Japanese  

    Country：Japan  

  • 慢性腎臓病モデルマウスにおける分子時計を介した腎‐肝‐腎連関機構の解明

    中尾 崇治、松永 直哉、吉田 優哉、鶴田 朗人、濵村 賢吾、近藤 英明、小柳 悟、大戸 茂弘

    第11回日本腎臓病薬物療法学会学術集会  2017.10 

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    Event date： 2017.10

    Language：Japanese  

    Country：Japan  

  • 防已黄耆湯とその有効成分シノメニンの抗侵害作用メカニズムの解明

    岡村 健正、小松 生明、濵村 賢吾、森永 紀、小川 鶴洋、櫻田 誓、高野 文秀、勝山 壮、林 貴史、櫻田 司

    第34回和漢医薬学会学術大会  2017.8 

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    Event date： 2017.8

    Language：Japanese  

    Country：Japan  

  • 神経障害性疼痛モデルマウス誘発性アロディニアにおけるBergamot Essential Oil (BEO) の持続皮下投与による影響

    田中 あかね、濵村 賢吾、勝山 壮、橋本 和人、下川 杏南、有竹 浩介、小松 生明、櫻田 司

    医療薬学フォーラム2017/第25回クリニカルファーマシーシンポジウム  2017.7 

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    Event date： 2017.7

    Language：Japanese  

    Country：Japan  

  • 防已黄耆湯の末梢性抗侵害刺激作用機構における内因性オピオイドの役割

    岡村 健正、小松 生明、濵村 賢吾、櫻田 誓、高野 文秀、勝山 壮、林 貴史、窪田 篤人、櫻田 司

    第11回日本緩和医療薬学会年会  2017.6 

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    Event date： 2017.6

    Language：Japanese  

    Country：Japan  

  • Serum exosomes in a mouse model of neuropathic pain enhance the formalin-induced nociceptive response International conference

    IASP, 16th World congress on pain  2016.9 

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    Event date： 2016.9

    Language：English  

    Country：Japan  

  • 神経障害性モデルマウスの血清中エクソソームは低濃度ホルマリン誘発侵害刺激行動を増強する

    濵村 賢吾、楠瀬 直喜、 勝山 壮、小松 生明、櫻田 司

    第36回鎮痛薬・オピオイドペプチドシンポジウム  2016.8 

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    Event date： 2016.8

    Language：Japanese  

    Country：Japan  

  • 神経障害性モデルマウスの血清中エクソソームは低濃度ホルマリン誘発侵害刺激行動を増強する

    居石 奈菜美、濵村 賢吾、楠瀬 直喜、勝山 壮、西村 友里、古川 翔太、田中 大晴、力久 諒派、荒牧 弘範、小松 生明、櫻田 司

    第24回クリニカルファーマシーシンポジウム/医療薬学フォーラム2016  2016.6 

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    Event date： 2016.6

    Language：Japanese  

    Country：Japan  

  • 慢性腎臓病モデルマウスにおける分子時計機構の腎-肝-腎連関を介した新規腎機能悪化機序の解明

    濵村 賢吾、松永 直哉、池田 恵理子、近藤 英明、池山 久子、徳重 和孝、古市 葉子、吉田 優哉、松田 将希、荒牧 弘範、小柳 悟、大戸 茂弘

    第23回クリニカルファーマシーシンポジウム/医療薬学フォーラム2015  2015.7 

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    Event date： 2015.7

    Language：Japanese  

    Country：Japan  

  • 分子時計機構を基盤とした腎不全進展メカニズム

    松永 直哉、池田 恵理子、濵村 賢吾、近藤 英明、池山 久子、徳重 和孝、古市 葉子、松田 将希、荒牧 弘範、小柳 悟、大戸 茂弘

    日本薬剤学会第30年会  2015.5 

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    Event date： 2015.5

    Language：Japanese  

    Country：Japan  

  • 慢性腎不全モデルマウスにおける肝代謝酵素発現日内変動変容機構の解明

    濵村 賢吾、松永 直哉、池田恵理子、古市 葉子、吉田 優哉、松田 将希、小柳 悟、大戸 茂弘

    第21回日本時間生物学会学術大会  2014.11 

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    Event date： 2014.11

    Language：Japanese  

    Country：Japan  

  • 慢性腎臓病モデルマウスにおける分子時計機構の腎-肝-腎連関を介した新規腎機能悪化機序の解明

    濵村 賢吾、松永 直哉、池田恵理子、古市 葉子、吉田 優哉、松田 将希、小柳 悟、大戸 茂弘

    第8回次世代を担う若手医療薬科学シンポジウム  2014.11 

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    Event date： 2014.11

    Language：Japanese  

    Country：Japan  

  • 分子時計機構を基盤とした慢性腎不全の新規治療標的分子の探索

    松永 直哉、池田 恵理子、濵村 賢吾、近藤 英明、一町 和史、池山 久子、徳重 和孝、古市 葉子、吉田 優哉、小柳 悟、大戸 茂弘

    第24回日本医療薬学会年会  2014.9 

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    Event date： 2014.9

    Language：Japanese  

    Country：Japan  

  • 皮膚の分子時計を基盤としたアクアポリン3 発現の日周リズム制御機構

    松永 直哉、一町 和史、濵村 賢吾、池田 恵理子、小柳 悟、大戸 茂弘

    医療薬学フォーラム2014/第22回クリニカルファーマシーシンポジウム  2014.6 

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    Event date： 2014.6

    Language：Japanese  

    Country：Japan  

  • Molecular basis for rhythmic expression of cytochromes P450 (CYPs) in serum-shocked HepG2 cells

    2013.3 

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    Event date： 2013.3

    Language：Japanese  

    Country：Japan  

  • MOLECULAR MECHANISM REGULATING 24-HOUR RHYTHM OF DOPAMINE RECEPTOR D3 EXPRESSION IN MOUSE STRIATUM

    2012.11 

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    Event date： 2012.11

    Language：Japanese  

    Country：Japan  

  • MOLECULAR BASIS FOR RHYTHMIC EXPRESSION OF CYTOCHROMES P450 (CYPS) IN SERUM-SHOCKED HEPG2 CELLS

    2012.11 

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    Event date： 2012.11

    Language：Japanese  

    Country：Japan  

  • ヒト培養肝細胞における薬物動態関連因子の発現リズム制御機構の解析

    松永 直哉、 滝口 貴子、 井上 美季、 楠瀬 直喜、 柿本 啓輔、 濵村 賢吾、 小柳 悟、 大戸 茂弘

    日本薬剤学会第27年会  2012.5 

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    Event date： 2012.5

    Language：Japanese  

    Country：Japan  

  • 慢性腎不全モデルマウスにおける薬物代謝酵素CYP3A11発現リズム変化

    濵村 賢吾、 松永 直哉、 池田 恵理子、 小柳 悟、 大戸 茂弘

    日本薬剤学会第25年会  2010.5 

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    Event date： 2010.5

    Language：Japanese  

    Country：Japan  

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Professional Memberships

  • SOCIETY FOR NEUROSCIENCE

    2019.4 - Present

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  • THE JAPANESE PHARMACOLOGICAL SOCIETY

    2017.10 - Present

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  • JAPANESE SOCIETY FOR CHRONOBIOLOGY

    2014.7 - Present

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  • THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN

    2010.4 - Present

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  • JAPANESE SOCIETY FOR CHRONOBIOLOGY

  • THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN

  • THE JAPANESE PHARMACOLOGICAL SOCIETY

  • SOCIETY FOR NEUROSCIENCE

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Research Projects

  • エクソソーム二重膜に着目した新たな神経障害性疼痛の治療標的としての可能性

    Grant number：21K11613  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • プレガバリンOD錠「ニプロ」のマウス神経障害性疼痛モデルを用いた鎮痛効果の検討

    2019.4 - 2020.3

    受託研究

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    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • 神経障害性疼痛の増悪に及ぼすエクソソームの役割

    Grant number：19K16936  2019 - 2020

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 中冨健康科学振興財団研究助成金/神経障害性疼痛の増悪に及ぼすエクソソームの役割

    2018

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    Grant type：Donation

  • エクソソーム二重膜上に存在する疼痛増悪因子の同定と新しい疼痛治療戦略の創出

    Grant number：17K18298  2017 - 2018

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 血清中エクソソームに着目した神経障害性疼痛の増悪機構解明と治療法への応用

    Grant number：15H06795  2015 - 2016

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 慢性腎不全モデルマウスにおける肝ＣＹＰ３Ａ１１発現変容機構の解明

    Grant number：13J04175  2013 - 2014

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

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    Authorship：Principal investigator  Grant type：Scientific research funding

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Educational Activities

  • I have been involved in the training of pharmacists by teaching lectures, exercises, and practical training for undergraduate pharmacy students.

Class subject

  • 薬学基礎実習Ⅳ

    2024.6 - 2024.8   Summer quarter

  • 薬物治療学Ⅱ

    2024.6 - 2024.8   Summer quarter

  • 薬剤・動態学

    2024.4 - 2024.6   Spring quarter

  • 薬物動態学ⅠA

    2024.4 - 2024.6   Spring quarter

FD Participation

  • 2024.3   Role：Participation   Title：有体物管理センターの業務および成果有体物収入の配分率の変更について

    Organizer：University-wide

  • 2023.11   Role：Participation   Title：第２回部局FD講演会「機関間連携」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.8   Role：Participation   Title：令和５年度４部局合同男女共同参画ＦＤ

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.4   Role：Participation   Title：令和５年度 第１回全学ＦＤ（新任教員の研修）The 1st All-University FD (training for new faculty members) in FY2023

    Organizer：University-wide

Other educational activity and Special note

  • 2024  Class Teacher 

  • 2023  Special Affairs