Modulation of cell physiology by bispecific nanobodies enabling changes in the intracellular localization of organelle proteins. Invited Reviewed International journal

Tsuruta A, Kanetani D, Shiiba Y, Inoki T, Yoshida Y, Matsunaga N, Koyanagi S, Ohdo S.

Biochem Pharmacol   215   115708   2023.4

Inhibition of tumor-derived C-C motif chemokine ligand 2 expression attenuates tactile allodynia in NCTC 2472 fibrosarcoma-inoculated mice. Invited Reviewed International journal

Taniguchi M, Yasukochi S, Yamakawa W, Tsurudome Y, Tsuruta A, Horiguchi M, Ushijima K, Yamashita T, Shindo N, Ojida A, Matsunaga N, Koyanagi S, Ohdo S.

Mol Pharmacol   104   73 - 79   2023.4

Discovery of chlorofluoroacetamide-based covalent inhibitors for severe acute respiratory syndrome coronavirus 2 3CL protease. Invited Reviewed International journal

Hirose Y, Shindo N, Mori M, Onitsuka S, Isogai H, Hamada R, Hiramoto T, Ochi J, Takahashi D, Ueda T, Caaveiro JMM, Yoshida Y, Ohdo S, Matsunaga N, Toba S, Sasaki M, Orba Y, Sawa H, Sato A, Kawanishi E, Ojida A.

J Med Chem. 2022 Oct 27;65(20):13852-13865.   65 ( 20 )   13852 - 13865   2022.10

RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells. Reviewed International journal

Omata Y, Okawa M, Haraguchi M, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S.

J Biol Chem.   298 ( 8 )   102184   2022.8

Diurnal expression of PD-1 on tumor-associated macrophages underlies the dosing time-dependent antitumor effects of the PD-1/PD-L1 inhibitor BMS-1 in B16/BL6 melanoma-bearing mice. Reviewed International journal

Tsuruta A, Shiiba Y, Matsunaga N, Fujimoto M, Yoshida Y, Koyanagi S, Ohdo S.

Mol Cancer Res.   20 ( 6 )   972 - 982   2022.6

Omeprazole suppresses oxaliplatin-induced peripheral neuropathy in a rodent model and clinical database. Reviewed International journal

Mine K, Kawashiri T, Inoue M, Kobayashi D, Mori K, Hiromoto S, Kudamatsu H, Uchida M, Egashira N, Koyanagi S, Ohdo S, Shimazoe T.

Int J Mol Sci.   23 ( 16 )   8859   2022.6

Ternary catalytic α-deuteration of carboxylic acids. Reviewed International journal

1   824 - 830   2022.4

Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis. Reviewed

Yoshida Y, Matsunaga N, Nakao T, Hamamura K, Kondo H, Ide T, Tsutsui H, Tsuruta A, Kurogi M, Nakaya M, Kurose H, Koyanagi S, Ohdo S.

Nature Commun   12 ( 1 )   2783   2021.5

Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord. Reviewed

Yasukochi S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

Biochem Pharmacol   185   114411   2021.4

RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene. Reviewed

Omata Y, Yamauchi T, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S

J Biol Chem   100601   2021.4

Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells. Reviewed

Ogino T, Matsunaga N, Tanaka T, Tanihara T, Terajima H, Yoshitane H, Fukada Y, Tsuruta A, Koyanagi S, Ohdo S.

Elife   10   e66155   2021.4

Bicyclobutane carboxylic amide as a cysteine-directed strained electrophile for selective targeting of proteins. Reviewed

Tokunaga K, Sato M, Kuwata K, Miura C, Fuchida H, Matsunaga N, Koyanagi S, Ohdo S, Shindo N, Ojida A.

J Am Chem Soc   142   18522 - 18531   2020.12

Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity Reviewed

Mizuki Kato, Yuya Tsurudome, Takumi Kanemitsu, Sai Yasukochi, Yuki Kanado, Takashi Ogino, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo

Scientific reports   10 ( 1 )   2020.12

Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines Reviewed

Mami Sato, Hirokazu Fuchida, Naoya Shindo, Keiko Kuwata, Keisuke Tokunaga, Guo Xiao-Lin, Ryo Inamori, Keitaro Hosokawa, Kosuke Watari, Tomohiro Shibata, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Mayumi Ono, Akio Ojida

ACS Medicinal Chemistry Letters   11 ( 6 )   1137 - 1144   2020.6

Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches Reviewed

Naoki Kusunose, Akito Tsuruta, Kengo Hamamura, Yuya Tsurudome, Yuya Yoshida, Takahiro Akamine, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo

Genes to Cells   25 ( 4 )   270 - 278   2020.4

Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells Reviewed

Shohei Uchinomiya, Naoya Matsunaga, Koichiro Kamoda, Ryosuke Kawagoe, Akito Tsuruta, Shigehiro Ohdo, Akio Ojida

Chemical Communications   56 ( 20 )   3023 - 3026   2020.3

Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs Reviewed

Yuki Kanado, Yuya Tsurudome, Yuji Omata, Sai Yasukochi, Naoki Kusunose, Takahiro Akamine, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo

Biochemical and Biophysical Research Communications   519 ( 3 )   613 - 619   2019.11

Chronopharmacological strategies focused on chrono-drug discovery Reviewed

Shigehiro Ohdo, Satoru Koyanagi, Naoya Matsunaga

Pharmacology and Therapeutics   202   72 - 90   2019.10

Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells. Reviewed International journal

62   677 - 685   2019.10

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes Reviewed

Kazuhiro Nishiyama, Takuro Numaga-Tomita, Yasuyuki Fujimoto, Tomohiro Tanaka, Chiemi Toyama, Akiyuki Nishimura, Tomohiro Yamashita, Matsunaga Naoya, Koyanagi Satoru, Yasu Taka Azuma, Yuko Ibuki, Koji Uchida, Shigehiro Ohdo, Motohiro Nishida

British Journal of Pharmacology   176 ( 18 )   3723 - 3738   2019.9

Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene. Reviewed International journal

Katamune C, Koyanagi S, Hashikawa KI, Kusunose N, Akamine T, Matsunaga N, Ohdo S.

J Biol Chem.   294 ( 2 )   547 - 558   2019.3

Microcurrent stimulation activates the circadian machinery in mice. Reviewed International journal

Matsunaga N, Yoshida Y, Kitajou N, Shiraishi A, Kusunose N, Koyanagi S, Ohdo S.

Biochem Biophys Res Commun.   513   293 - 299   2019.2

Selective and Reversible Modification of Kinase Cysteines with Chlorofluoroacetamides. Reviewed International journal

Shindo N, Fuchida H Sato H, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunag K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A.

15   250 - 258   2019.1

Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor. Reviewed International journal

Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S.

Cancer Res   78   3698 - 3708   2018.10

Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model. Reviewed International journal

Akamine T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

Biochem Biophys Res Commun   503   181 - 187   2018.10

Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function. Reviewed International journal

Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.

Sci Rep   8   9072   2018.10

Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system. Reviewed International journal

Kimura H, Matsunaga N, Kakimoto K, Watanabe M, Tsuruta A, Kusunose N, Shiromizu S, Koyanagi S, Ohdo S.

Biochem Biophys Res Commun   503   1063 - 1069   2018.10

Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice Reviewed

Takashi Matsunaga, Matsunaga Naoya, Naoki Kusunose, Eriko Ikeda, Hiroyuki Okazaki, Keisuke Kakimoto, Kengo Hamamura, Koyanagi Satoru, Shigehiro Ohdo

Biochemical and Biophysical Research Communications   498 ( 1 )   86 - 91   2018.3

Optimizing the dosing schedule of L-asparaginase improves its anti-tumor activity in breast tumor-bearing mice Reviewed

Shoya Shiromizu, Naoki Kusunose, Matsunaga Naoya, Koyanagi Satoru, Shigehiro Ohdo

Journal of Pharmacological Sciences   2018.1

Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis Reviewed

Ken Ichi Hashikawa, Chiharu Katamune, Naoki Kusunose, Matsunaga Naoya, Koyanagi Satoru, Shigehiro Ohdo

Scientific Reports   7 ( 1 )   2017.12

Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light–dark cycle in mice Reviewed

134 ( 4 )   211 - 217   2017.8

Breast cancer resistance to antiestrogens is enhanced by increased ER degradation and ERBB2 expression Reviewed

Tomohiro Shibata, Kosuke Watari, Hiroto Izumi, Akihiko Kawahara, Satoshi Hattori, Chihiro Fukumitsu, Yuichi Murakami, Ryuji Takahashi, Uhi Toh, Ken Ichi Ito, Shigehiro Ohdo, Maki Tanaka, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono

Cancer Research   77 ( 2 )   545 - 556   2017.1

Vancomycin induces reactive oxygen species-dependent apoptosis via mitochondrial cardiolipin peroxidation in renal tubular epithelial cells Reviewed

Yuya Sakamoto, Takahisa Yano, Yuki Hanada, Aki Takeshita, Fumika Inagaki, Satohiro Masuda, Matsunaga Naoya, Koyanagi Satoru, Shigehiro Ohdo

European Journal of Pharmacology   800   48 - 56   2017.1

Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα Reviewed

292 ( 52 )   21397 - 21406   2017.1

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease Reviewed

Matsunaga Naoya, Eriko Ikeda, Keisuke Kakimoto, Miyako Watanabe, Naoya Shindo, Akito Tsuruta, Hisako Ikeyama, Kengo Hamamura, Kazuhiro Higashi, Tomohiro Yamashita, Hideaki Kondo, Yuya Yoshida, Masaki Matsuda, Takashi Ogino, Kazutaka Tokushige, Kazufumi Itcho, Yoko Furuichi, Takaharu Nakao, Kaori Yasuda, Atsushi Doi, Toshiaki Amamoto, Hironori Aramaki, Tsuda Makoto, Kazuhide Inoue, Akio Ojida, Koyanagi Satoru, Shigehiro Ohdo

EBioMedicine   13   262 - 273   2016.11

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia Reviewed

Koyanagi Satoru, Naoki Kusunose, Marie Taniguchi, Takahiro Akamine, Yuki Kanado, Yui Ozono, Takahiro Masuda, Yuta Koro, Matsunaga Naoya, Tsuda Makoto, Michael W. Salter, Kazuhide Inoue, Shigehiro Ohdo

Nature Communications   7   2016.10

Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study. Biol Pharm Bull. 2016 Aug 1;39(8):1238-1246. Invited Reviewed International journal

Elsayed M, Kobayashi D, Kubota T, Matsunaga N, Murata R, Yoshizawa Y, Watanabe N, Matsuura T, Tsurudome Y, Ogino T, Ohdo S, Shimazoe T.

Biol Pharm Bull. 2016 Aug 1;39(8):1238-1246.   2016.8

Different Roles of Negative and Positive Components of the Circadian Clock in Oncogene-induced Neoplastic Transformation. Invited Reviewed

Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S.

J Biol Chem. 2016 May 13;291(20):10541-10550.   2016.5

Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression. J Biol Chem. 2016 Mar 25;291(13):7017-7028. Invited Reviewed International journal

Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Tsuruta A, Tsurudome Y, Ogino T, Hara Y, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S.

J Biol Chem. 2016 Mar 25;291(13):7017-7028.   2016.3

Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction. J Biol Chem. 2016 Mar 4;291(10):4913-4927. Invited Reviewed International journal

Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.

J Biol Chem. 2016 Mar 4;291(10):4913-4927.   2016.3

Mitomycin C modulates the circadian oscillation of clock gene period 2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts.Biochem Biophys Res Commun. 2015 Nov 6;467(1):157-163. Invited Reviewed International journal

Kusunose N, Matsunaga N, Kimoto K, Akamine T, Hamamura K, Koyanagi S, Ohdo S, Kubota T.

Biochem Biophys Res Commun. 2015 Nov 6;467(1):157-163.   2015.11

Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice. Reviewed International journal

Akamine T, Koyanagi S, Kusunose N, Hashimoto H, Taniguchi M, Matsunaga N, Ohdo S:

J Pharmacol Exp Ther 354: 65-72 (2015)   2015.9

Circadian modulation in the intestinal absorption of P-glycoprotein substrates in monkeys. Mol Pharmacol 88: 29-37 (2015) Reviewed International journal

Iwasaki M, Koyanagi S, Suzuki N, Katamune C, Matsunaga N, Watanabe N, Takahashi M, Izumi T, Ohdo S:

Mol Pharmacol 88: 29-37 (2015)   2015.7

Modulation of peroxisome proliferator-activated receptor-α activity by bile acids causes circadian changes in the intestinal expression of Octn1/Slc22a4 in mice. Reviewed International journal

2015.2

Statin inhibits the expression of secretory phospholipase A2 and subsequent monocyte chemoattractant protein-1 in human endothelial cells. Reviewed International journal

Sonoki K, Iwase M, Ohdo S, Ieiri I, Takata Y, Kitazono T.

J Cardiovasc Pharmacol. 2014 Dec;64(6):489-96.   2014.12

Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1. Reviewed International journal

2014.9

24-hour rhythm of aquaporin-3 function in the epidermis is regulated by molecular clocks. Reviewed International journal

Matsunaga N, Itcho K, Hamamura K, Ikeda E, Ikeyama H, Furuichi Y, Watanabe M, Koyanagi S, Ohdo S.

J Invest Dermatol.   2014.6

Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice. Reviewed International journal

Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S.

Mol Pharmacol.   2014.5

Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma. Reviewed International journal

Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S.

Cancer Res.   2014.1

Two-dimensional high-performance liquid chromatographic determination of day-night variation of D-alanine in mammals and factors controlling the circadian changes. Reviewed International journal

Karakawa S, Miyoshi Y, Konno R, Koyanagi S, Mita M, Ohdo S, Hamase K.

Anal Bioanal Chem.   2013.10

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S. Reviewed International journal

Hayashi Y, Koyanagi S, Kusunose N, Okada R, Wu Z, Tozaki-Saitoh H, Ukai K, Kohsaka S, Inoue K, Ohdo S, Nakanishi H.

Sci Rep.   2013.9

A disruption mechanism of the molecular clock in a MPTP mouse model of Parkinson's disease. Reviewed International journal

Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda E, Shiba T, Yamato M, Yamada K, Koyanagi S, Ohdo S. A disruption mechanism of the molecular clock in a MPTP mouse model of Parkinson'

Neuromolecular Med   2013.6

Molecular mechanism regulating 24-hour rhythm of dopamine D3 receptor expression in mouse ventral striatum. Reviewed International journal

Ikeda E, Matsunaga N, Kakimoto K, Hamamura K, Hayashi A, Koyanagi S, Ohdo S.

Mol Pharmacol   2013.5

Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs. Reviewed International journal

Ogi S, Fujita H, Kashihara M, Yamamoto C, Sonoda K, Okamoto I, Nakagawa K, Ohdo S, Tanaka Y, Kuwano M, Ono M.

Cancer Sci   2013.5

ゲムシタビン注射用製剤　後発医薬品の溶解性に関する検討． Reviewed

赤嶺孝祐、 若松菜摘、 横山絵里、 松永直哉、 小柳悟、 大戸茂弘．　

医療薬学   2013.4

Rhythmic control of the ARF-MDM2 pathway by ATF4 underlies circadian accumulation of p53 in malignant cells. Reviewed International journal

Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S.

Cancer Res   2013.4

The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis. Reviewed International journal

Kuroki K, Hirose K, Okabe Y, Fukunaga Y, Takahashi A, Shiroishi M, Kajikawa M, Tabata S, Nakamura S, Takai T, Koyanagi S, Ohdo S, Maenaka K.

Hum Immunol   2013.4

Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice. Reviewed International journal

2013.1

IL-6 Receptor Is a Possible Target against Growth of Metastasized Lung Tumor Cells in the Brain. Reviewed International journal

Noda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, Akimoto N, Teramoto N, Fujita K, Ohdo S, Iguchi H.

Int J Mol Sci   2012.12

Pharmaceutical and therapeutic equivalence study of the generic medicine containing loxoprofen sodium. Reviewed

Kaneshige S, Kobayashi M, Matsunaga N,Koyanagi S, Ohdo S, Kamimura H.

Japanese Pharmacology & Therapeutics   2012.12

Telmisartan and N-acetylcysteine suppress group V secretory phospholipase A2 expression in TNFα-stimulated human endothelial cells and reduce associated atherogenicity. Reviewed International journal

2012.10

Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways. Reviewed International journal

2012.10

Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain. Reviewed International journal

Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo S.

Mol Pharmacol   2012.8

Time-dependent interaction between differentiated embryo chondrocyte-2 and CCAAT/enhancer-binding protein α underlies the circadian expression of CYP2D6 in serum-shocked HepG2 cells. Reviewed International journal

2012.5

Intestinal expression of mouse Abcg2/Bcrp gene is under the control of circadian clock-activating transcription factor-4 pathway. Reviewed International journal

Hamdan AM, Koyanagi S, Wada E, Kusunose N, Murakami Y, Matsunaga N, Ohdo S.

J Biol Chem.   2012.5

Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors. Reviewed International journal

Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.

Cancer Res.   2012.1

Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner. Reviewed International journal

Tanimura N, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

Toxicology   2011.12

cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. Reviewed International journal

Koyanagi S, Hamdan AM, Horiguchi M, Kusunose N, Okamoto A, Matsunaga N, Ohdo S.

J Biol Chem.   2011.9

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. Reviewed International journal

Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K.

Brain   134 ( (Pt 4) )   2011.4

Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes. Reviewed International journal

Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S.

Toxicology 280(3),144 -151, 2011.   2011.2

ベザフィブラート後発医薬品の製剤学的および治療学的同等性試験． Reviewed International journal

兼重晋、池田祐輔、松永直哉、小柳悟、大戸茂弘、神村英利．

薬理と治療   2011.1

グリクラジド後発医薬品の製剤学的および治療学的同等性試験． Reviewed International journal

兼重晋、有馬希、松永直哉、小柳悟、大戸茂弘、神村英利．

薬理と治療   2010.12

Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. Reviewed International journal

Kusunose N, Koyanagi S, Hamamura K, Matsunaga N, Yoshida M, Uchida T, Tsuda M, Inoue K, Ohdo S.

Mol Pain   2010.11

Proxisome proliferator-activated receptor-α mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice. Reviewed International journal

2010.10

Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice. Reviewed International journal

Okazaki F, Matsunaga N, Okazaki H, Utoguchi N, Suzuki R, Maruyama K, Koyanagi S, Ohdo S.

Cancer Res   2010.8

Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner. Reviewed International journal

Oishi K, Koyanagi S, Matsunaga N, Kadota K, Ikeda E, Hayashida S, Kuramoto Y, Shimeno H, Soeda S, Ohdo S.

Mol Pharmacol   2010.7

Hypoxia-response plasmid vector producing bcl-2 shRNA enhances the apoptotic cell death of mouse rectum carcinoma. J Pharmacol Sci. 113(4), 353-361, 2010. Reviewed International journal

Fujioka T, Matsunaga N, Okazaki H, Koyanagi S, Ohdo S.

J Pharmacol Sci.   2010.7

Glucocorticoid-dependent expression of O6-methylguanine-DNA methyltransferase gene modulates the dacarbazine-induced hepatotoxicity in mice. Reviewed International journal

Horiguchi M, Kim J, Matsunaga N, Kaji H, Egawa T, Makino K, Koyanagi S, Ohdo S.

J Pharmacol Exp Ther   2010.3

Relations of lysophosphatidylcholine in low-density lipoprotein with serum lipoprotein-associated phospholipase A2, paraoxonase and homocysteine thiolactonase activities in patients with type 2 diabetes mellitus. Reviewed International journal

Sonoki K, Iwase M, Sasaki N, Ohdo S, Higuchi S, Matsuyama N, Iida M.

Diabetes Res Clin Pract.   2009.11

Molecular clock mechanisms of drug metabolism. Reviewed International journal

Ohdo S, Matsunaga N, Koyanagi S.

16th International Conference on Cytochrome P450: Functional genomics   2009.11

Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene.　 Reviewed International journal

2009.10

Influence of intermittent hypoxia on the signal transduction pathways to inflammatory response and circadian clock regulation. Reviewed International journal

Burioka N, Koyanagi S, Fukuoka Y, Okazaki F, Fujioka T, Kusunose N, Endo M, Suyama H, Chikumi H, Ohdo S, Shimizu E.

Life Sci.   2009.8

Simple and rapid genotyping of D-amino acid oxidase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis. Reviewed International journal

Tojo Y, Hamase K, Konno R, Koyanagi S, Ohdo S, Zaitsu K.

J Sep Sci.   2009.2

Role of glucocorticoid receptor in the regulation of cellular sensitivity to irinotecan hydrochloride. Reviewed International journal

Akagi T, Fukagawa T, Kage Y, To H, Matsunaga N, Koyanagi S, Uchida A, Fujii A, Iba H, Ikemura T, Aramaki H, Higuchi S, Ohdo S.

J Pharmacol Sci.   2009.2

Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling. Reviewed International journal

Nakagawa H., Koyanagi S., Kuramoto Y., Yoshizumi A., Matsunaga N., Shimeno H., Soeda S., Ohdo S.

J Pharmacol Sci.   2008.9

Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice. Reviewed International journal

Murakami Y., Higashi Y., Matsunaga N., Koyanagi S., Ohdo S.

Gastroenterology   2008.9

Dosing schedule-dependent change in the disruptive effects of interferon-α on the circadian clock function. Reviewed International journal

2008.9

Pre-administration of docetaxel protects against adriamycin-induced cardiotoxicity. Reviewed International journal

Sakaguchi, H., Kodama, A., Tomonari, M., Ando, Y., Tabuchi, M., To, H., Araki, R., Kitahara, T., Sasaki, H., Ohdo, S., Higuchi, S.

Breast Cancer Res. Treat.   2008.4

The molecular mechanism regulating 24-hour rhythm of CYP2E1 expression in the mouse liver. Reviewed International journal

Matsunaga, N., Ikeda, M., Takiguchi, T., Koyanagi, S., Ohdo, S.

Hepatology   2008.4

Circadian changes of D-alanine and related compounds in rats and the effect of restricted feeding on their amounts. Reviewed International journal

Morikawa, A., Hamase, K., Miyoshi, Y., Koyanagi, S., Ohdo, S., Zaitsu, K.

J. Chromatography B   2008.4

Clock gene dysfunction in patients with obstructive sleep apnoea syndrome. Reviewed International journal

Burioka, N., Koyanagi, S., Endo, M., Takata, M., Fukuoka, Y., Miyata, M., Takeda, K., Chikumi, H., Ohdo, S., Shimizu, E.

Eur. Respir. J.   2008.4

Secretory PLA(2) inhibitor indoxam suppresses LDL modification and associated inflammatory responses in　TNFα-stimulated human endothelial cells. Reviewed International journal

2008.4

Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: A possible mechanism of chemotherapy-induced circadian rhythm disturbances. Reviewed International journal

Terazono, H., Hamdan, A., Matsunaga, N., Hayasaka, N., Kaji, H., Egawa, T., Makino, K., Shigeyoshi, Y., Koyanagi, S., Ohdo, S.

Biochem. Pharmacol.   2008.3

Lysophosphatidylcholine contents in plasma LDL in patients with type 2 diabetes mellitus: Relation with lipoprotein-associated phospholipase A2 and effects of simvastatin treatment. Reviewed International journal

Iwase, M., Sonoki, K., Sasaki, N., Ohdo, S., Higuchi, S., Hattori, H., Iida, M.

Atherosclerosis   2008.1

Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells. Reviewed International journal

Takiguchi, T., Tomita, M., Matsunaga, N., Nakagawa, H., Koyanagi, S., Ohdo, S.

Pharmacogenetics and Genomics   2007.12

Possible mechanisms for the pharmacokinetic interaction between phenytoin and folinate in rats. Reviewed International journal

Yamasaki, D., Tsujimoto, M., Ohdo, S., Ohtani, H., Sawada, Y.

Therapeutic Drug Monitoring   2007.8

Effects of dosing interval on the pharmacokinetic interaction between oral small spherical activated charcoal and amlodipine in humans. Reviewed International journal

Tanaka, C., Ohtani, H., Tsujimoto, M., Ohdo, S., Taniguchi, M., Mizooku, Y., Saitoh, Y., Kimura,,M. Uchimaru, H., Irie, S., Sawada, Y.

Journal of Clinical Pharmacology   2007.7

Phase III long-term study and comparative clinical study of nipradilol ophthalmic solution in patients with primary open-angle glaucoma and ocular hypertension. Part 2. Reviewed International journal

Kanno, M., Araie, M., Masuda, K., Takase, M., Kitazawa, Y., Shiose, Y., Azuma, I., Ogawa, N., Ohdo, S.

Arzneimittel-Forschung   2006.12

Basis for dosing time-dependent change in the anti-tumor effect of imatinib in mice. Reviewed International journal

Nakagawa, H., Takiguchi, T., Nakamura, M., Furuyama, A., Koyanagi, S., Aramaki, H., Higuchi, S., Ohdo, S.

Biochemical Pharmacology   2006.11

Phase III long-term study and comparative clinical study of nipradilol ophthalmic solution in patients with primary open-angle glaucoma and ocular hypertension. Reviewed International journal

Kanno, M., Araie, M., Masuda, K., Takase, M., Kitazawa, Y., Shiose, Y., Azuma, I., Ogawa, N., Ohdo, S.

Arzneimittel-Forschung   2006.11

Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver. Reviewed International journal

Endocrinology   2006.11

Chronobiological disturbances with hyperthermia and hypercortisolism induced by chronic mild stress in rats. Reviewed International journal

Ushijima, K., Morikawa, T., To, H., Higuchi, S., Ohdo, S.

Behavioural Brain Research   2006.10

Glucocorticoid is involved in food-entrainable rhythm of オ-opioid receptor expression in mouse brainstem and analgesic effect of morphine. Reviewed International journal

2006.5

Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues. Reviewed International journal

Koyanagi, S., Okazawa, S., Kuramoto, Y., Ushijima, K., Shimeno, H., Soeda, S., Okamura, H., Ohdo, S.

Mol. Endocrinol.   2006.5

Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones. Reviewed International journal

Kuramoto, Y., Hata, K., Koyanagi, S., Ohdo, S., Shimeno, H., Soeda, S.

Biochemical Pharmacology   2006.4

Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Reviewed International journal

Fuchikami, H., Satoh, H., Tsujimoto, M., Ohdo, S., Ohtani, H., Sawada, Y.

Drug Metabolism & Disposition.   2006.4

Cell cycle dependent pharmacology of methotrexate in HL-60. Reviewed International journal

Yamauchi, A., Ichimiya, T., Inoue, K., Taguchi, Y., Matsunaga, N., Koyanagi, S., Fukagawa, T., Aramaki, H., Higuchi, S., Ohdo, S.

Journal of Pharmacological Sciences   99 ( 4 )   335 - 341   2005.12

Glucocorticoid administration increases hPer1 mRNA levels in human peripheral blood mononuclear cells in vitro or in vivo. Reviewed International journal

Fukuoka, Y., Burioka, N., Takata, M., Ohdo, S., Miyata, M., Endo, M., Shimizu, E.

Journal of Biological Rhythms   20 ( 6 )   550 - 553   2005.12

Glucocorticoid hormone regulates the circadian coordination of u-opioid receptor expression in mouse brainstem. Reviewed International journal

Yoshida, M., Koyanagi, S., Matsuo, A., Fujioka, T., To, H., Higuchi, S., Ohdo, S.

Journal of Pharmacology and Experimental Therapeutics   315 ( 3 )   1119 - 1124   2005.12

Chronopharmacological study of antidepressants in forced swimming test of mice. Reviewed International journal

Ushijima K., Sakaguchi H., Sato Y., To H., Koyanagi S., Higuchi S., Ohdo S.

Journal of Pharmacology and Experimental Therapeutics   315 ( 2 )   764 - 770   2005.11

Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder. Reviewed International journal

Takimoto M., Hamada A., Tomoda A., Ohdo S., Ohmura T., Sakato H., Kawatani J., Jodoi T., Nakagawa H., Terazono H., Koyanagi S., Higuchi S., Kimura M., Tukikawa H., Irie S., Saito H., Miike T.

Am. J. Physiol. Regul. Integr. Comp. Physiol.   289 ( 5 )   R1273 - R1279   2005.11

Therapeutic index by combination of adriamycin and docetaxel depends on dosing time in mice. Reviewed International journal

Tabuchi, M., To, H., Sakaguchi, H., Goto N., Takeuchi, A., Higuchi, S., Ohdo, S.

Cancer Research.   65 ( 18 )   8448 - 8454   2005.9

β2-adrenoceptor agonists induce the mammalian clock gene, hPer1, mRNA in cultured human bronchial epithelium cells in vitro. Reviewed International journal

22 ( 4 )   777 - 783   2005.4

Dexamethasone influences human clock gene expression in bronchial epithelium and peripheral blood mononuclear cells in vitro. Reviewed International journal

Burioka, N., Takata, M., Okano, Y., Ohdo, S., Fukuoka, Y., Miyata, M., Takane, H., Endo, M., Suyama, H., Shimizu, E.

Chronobiology International   22 ( 3 )   585 - 590   2005.3

Effect of haloperidol on mPer1 gene expression in mouse SCN. Reviewed International journal

Viyoch, J., Matsunaga, N., Yoshida, M., To, H., Higuchi, S., Ohdo, S.

Journal of Biological Chemistry   280 ( 8 )   6309 - 6315   2005.2

Doxorubicin chronotherapy in Japanese outpatients with breast cancer. Reviewed International journal

To, H., Saito, T., Ohdo, S., Higuchi, S., Fujimura, A., Kobayashi, E.

Drugs R D   2005.2

Influence of feeding schedule on 24-hr rhythm of hepatotoxicity induced by acetaminophen in mice. Reviewed International journal

Matsunaga, N., Nakamura, N., Yoneda, N., Qin, T., Terazono, H., To, H., Higuchi, S., Ohdo, S.

Journal of Pharmacology and Experimental Therapeutics   311 ( 2 )   594 - 600   2004.11

24-hr oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins. Reviewed International journal

Nakagawa, H., Koyanagi, S., Takiguchi, T., Kuramoto, Y., Soeda, S., Shimeno, H., Higuchi, S., Ohdo, S.

Cancer Research   64 ( 22 )   8328 - 8333   2004.11

Influence of dosing schedule on toxicity and antitumor effect by combination of adriamycin and docetaxel in mice. Reviewed International journal

To, H., Shin,M., Tabuchi, M., Sakaguchi, H., Takeuchi, A., Matsunaga,N., Higuchi, H., Ohdo, S.

Clinical Cancer Research   10 ( 2 )   762 - 769   2004.1

Chronopharmacology of melatonin in mice to maximize the antitumor effect and minimize the rhythm disturbance effect. Reviewed International journal

Akagi, T., Ushinohama, K., Ikesue, S., Yukawa, E., Higuchi, S., Hamase, K., Zaitsu, K., Ohdo, S.

Journal of Pharmacology and Experimental Therapeutics   308 ( 1 )   378 - 384   2004.1

A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells. Reviewed International journal

Koyanagi, S., Kuramoto, Y., Nakagawa, H., Aramaki, H., Ohdo, S., Soeda, S., Shimeno, H.

Cancer Research   63 ( 21 )   7277 - 7283   2003.11

Dilazep and fenofibric acid inhibit MCP-1 mRNA expression in glycoxidized LDL-stimulated human endothelial cells. Reviewed International journal

Sonoki, K., Iwase, M., Lino, K., Ichikawa, K.,Yoshinari, M., Ohdo, S., Higuchi, S., Iida, M.

European Journal of Pharmacology   475 ( 1-3 )   139 - 147   2003.8

Chronopharmacology of analgesic effect and its tolerance induced by morphine in mice. Reviewed International journal

Yoshida, M., Ohdo, S., Takane, H., Tomiyoshi, Y., Matsuo, A., Yukawa, E., Higuchi, S.

Journal of Pharmacology and Experimental Therapeutics   305 ( 3 )   1200 - 1205   2003.6

Dosing-time dependency of doxorubicin-induced cardiotoxicity and bone marrow toxicity in rats. Reviewed International journal

To, H., Ohdo, S., Shin, M., Uchimaru, H., Yukawa, E., Higuchi, S., Fujimura, A., Kobayashi, E.

Journal of Pharmacy and Pharmacology   55 ( 6 )   803 - 810   2003.6

Adrenergic regulation of clock gene expression in mouse liver. Reviewed International journal

Terazono, H., Mutoh, T., Yamaguchi, S., Kobayashi, M., Akiyama, M., Udo, R., Ohdo, S., Okamura, H., Shibata, S.

Proc Natl Acad Sci   100 ( 11 )   6795 - 6800   2003.5

Atherogenic role of lysophosphatidylcholine in low-density lipoprotein modified by phospholipase A(2) and in diabetic patients: Protection by nitric oxide donor. Reviewed International journal

Sonoki, K., Iwase, M., Lino, K., Ichikawa, K., Ohdo, S., Higuchi, S., Yoshinari, M., Iida, M.

Metabolism   52 ( 3 )   308 - 314   2003.5

Optimizing the dosing schedule of TNP-470 [o-(chloroacetyl-carbamoyl) fumagillol] enhances its antitumor and antiangiogenic efficacies. Reviewed International journal

Koyanagi, S., Nakagawa, H., Kuramoto, Y., Ohdo, S., Soeda, S., Shimeno, H.

Journal of Pharmacology and Experimental Therapeutics   304 ( 2 )   669 - 674   2003.2

Cell kinetics-dependent antitumor effect of irinotecan hydrochloride induced by the synchronizing effect of hydroxyurea: cell kinetics and dosing time. Reviewed International journal

Akagi, T., Ushinohama, K., Kage, Y., Ishizaki, T., Makinosumi, T., Yamauchi, A., Taguchi, Y., Inoue, K., Yukawa, E., Higuchi, S., Ohdo, S.

Life Sciences   72 ( 10 )   1183 - 1197   2003.1

Alteration of intrinsic biological rhythms during interferon treatment and its possible mechanism. Reviewed International journal

Koyanagi, S., Ohdo, S.

Molecular Pharmacology   62 ( 6 )   1393 - 1399   2002.12

Relationship between 24-hr rhythm in antiviral effect of interferon-β and interferon-α/βreceptor expression in mice. Reviewed International journal

90 ( 4 )   304 - 312   2002.12

Daily expression of mRNAs for the mammalian clock genes Per2 and Clock in mouse suprachiasmatic nuclei and liver and human peripheral blood mononuclear cells. Reviewed International journal

Takata, M., Burioka, N., Ohdo, S., Takane, H., Terazono, H., Miyata, M., Sako, T., Suyama, H., Fukuoka, Y., Tomita, K., Shimizu, E.

Japanese Journal of Pharmacology   90 ( 3 )   263 - 269   2002.11

Glycoxidized low-density lipoprotein enhances monocyte chemoattractant protein-1 mRNA expression in human umbilical vein endothelial cells: relation to lysophosphatidylcholine contents and inhibition by nitric oxide donor. Metabolism 51,9, 1135-1142, 2002. Reviewed International journal

Sonoki, K., Yoshinari, M., Iwase, M., Lino, K., Ichikawa, K., Ohdo, S., Higuchi, S., Iida, M.

Metabolism   51 ( 9 )   1135 - 1142   2002.9

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein. Reviewed International journal

Kurata, Y., Ieiri, I., Kimura, M., Morita, T., Irie, S., Urae, A., Ohdo, S., Ohtani, H., Sawada, Y., Higuchi, S., Otsubo, K.

Clinical Pharmacology & Therapeutics   72 ( 2 )   209 - 219   2002.8

Pharmacoepidemiologic detection of calcium channel blocker-induced change on digoxin clearance using multiple trough screen analysis. Reviewed International journal

Suematsu, F., Yukawa, E., Yukawa, M., Minemoto, M., Ohdo, S., Higuchi, S., Goto, Y.

Biopharmaceutics & Drug Disposition   23 ( 5 )   173 - 181   2002.7

Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in japanese patients. Reviewed International journal

Yukawa, E., Hokazono, T., Yukawa, M., Ichimaru, R., Maki, T., Matsunaga, K., Ohdo, S., Anai, M., Higuchi, S., Goto, Y.

Clinical Pharmacokinetics   41 ( 2 )   153 - 159   2002.2

Pharmacoepidemiologic investigation of clonazepam relative clearance by mixed-effect modeling using routine clinical pharmacokinetic data in japanese patients. Reviewed International journal

Yukawa, E., Satou, M., Nonaka, T., Yukawa, M., Ohdo, S., Higuchi, S., Kuroda, T., Goto, Y.

Journal of Clinical Pharmacology   42 ( 1 )   81 - 88   2002.1

Pharmacoepidemiologic investigation of a clonazepam-carbamazepine interaction by mixed effect modeling using routine clinical pharmacokinetics data in japanese patients. Reviewed International journal

Yukawa, E., Nonaka, T., Yukawa, M., Ohdo, S., Higuchi, S., Kuroda, T., Goto, Y.

Journal of Clinical Psychopharmacology   21 ( 6 )   588 - 593   2001.12

Population pharmacokinetics of digoxin in japanese patients: A 2-compartment pharmacokinetic model. Reviewed International journal

Yukawa, E., Suematsu, F., Yukawa, M., Minemoto, M., Ohdo, S., Higuchi, S., Goto, Y., Aoyama, T.

Clinical Pharmacokinetics   40 ( 10 )   773 - 781   2001.10

Influence of age and comedication on steady-state clonazepam serum level-dose ratios in japanese epileptic patients. Reviewed International journal

Yukawa, E., Satou, M., Nonaka, T., Yukawa, M., Ohdo, S., Higuchi, S., Kuroda, T., Goto, Y.

Journal of Clinical Pharmacy and Therapeutics.   26 ( 5 )   375 - 379   2001.10

Dosing time-dependent tolerance of catalepsy by repetitive administration of haloperidol in mice. Reviewed International journal

Viyoch , J., Ohdo, S., Yukawa, E., Higuchi, S.

Journal of Pharmacology and Experimental Therapeutics   298 ( 3 )   964 - 969   2001.9

Estimation of rhG-CSF absorption kinetics after subcutaneous administration using a modified wagner-nelson method with a nonlinear elimination model. Reviewed International journal

Hayashi, N., Aso, H., Higashida, M., Kinoshita, H., Ohdo, S., Yukawa, E., Higuchi, S.

European Journal of Pharmaceutical Sciences   13 ( 2 )   151 - 158   2001.5

Population-based investigation of relative clearance of digoxin in japanese neonates and infants by multiple-trough screen analysis. Reviewed International journal

Suematsu, F., Yukawa, E., Yukawa, M., Minemoto, M., Ohdo, S., Higuchi, S., Goto, Y.

European Journal of Clinical Pharmacology   57 ( 1 )   19 - 24   2001.4

Changing the dosing schedule minimizes the disruptive effects of interferon on clock function. Reviewed International journal

Ohdo, S. , Koyanagi , S., Suyama, H., Higuchi, S., Aramaki, H.

Nature Medicine   7 ( 3 )   356 - 360   2001.3

Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells. Reviewed International journal

Takane, H., Ohdo, S., Yamada, T., Koyanagi, S., Yukawa, E., Higuchi, S.

Life Sciences   68 ( 12 )   1449 - 1455   2001.2

Effect of dosing schedule on pharmacokinetics of alpha interferon and anti-alpha interferon neutralizing antibody in mice. Reviewed International journal

Wang, D.S., Ohdo, S., Koyanagi, S., Takane, H., Aramaki, H., Yukawa, E., Higuchi, S.

Antimicrobial Agents and Chemotherapy   45 ( 1 )   176 - 180   2001.1

Epidemiologic investigation of the relative clearance of haloperidol by mixed-effect modeling using routine clinical pharmacokinetic data in japanese patients. Reviewed International journal

Yukawa, E., Hokazono, T., Funakoshi, A., Yukawa, M., Ohdo, S., Higuchi, S., Ichimaru, R., Maki, T., Matsunaga, K., Anai, M., Goto, Y.

Journal of Clinical Psychopharmacology   20 ( 6 )   685 - 690   2000.12

Pharmacokinetic interactions among phenobarbital, carbamazepine, and valproic acid in pediatric japanese patients: clinical considerations on steady-state serum concentration-dose ratios. Reviewed International journal

Yukawa, E., Hokazono, T., Satou, M., Ohdo, S., Higuchi, S., Aoyama, T.

American Journal of Therapeutics   2000.9

Basis for dosing time-dependent changes in the antiviral activity of interferon-α in mice. Reviewed International journal

294 ( 2 )   488 - 493   2000.8

Chronopharmacology of antitumor effect induced by interferon-β in tumor-bearing mice. Reviewed International journal

294 ( 2 )   746 - 752   2000.8

Close association between clearance of recombinant human granulocyte colony-stimulating factor (G-CSF) and G-CSF receptor on neutrophils in cancer patients. Reviewed International journal

Terashi, K., Oka, M., Ohdo, S., Furukubo, T., Ikeda, C., Fukuda, M., Soda H., Higuchi, S., Kohno, S.

Antimicrobial Agents and Chemotherapy   43 ( 1 )   21 - 24   1999.1

Chronopharmacological study of Ke-Si-To components in mice. Reviewed International journal

Ohdo, S., Ogawa, N.,Song, J.G., Higuchi, S.

Life Sciences   62 ( 22 )   2057 - 2064   1998.6

Influence of dosing time on pharmacological　action of G-CSF in mice. Life Sciences 62,12,PL163-168,1998. Reviewed International journal

62 ( 12 )   PL163 - PL168   1998.4

Chronopharmacology of granulocyte colony-stimulating factor in mice. Invited Reviewed International journal

Ohdo, S., Arata, N., Furukubo, T., Yukawa, E., Higuchi, S., Nakano, S., Ogawa, N.

Journal of Pharmacology and Experimental Therapeutics   285 ( 1 )   242 - 246   1998.4

Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling. Invited Reviewed International journal

European Journal of Clinical Pharmacology   54 ( 1 )   69 - 74   1998.3

Population-based investigation of valproic acid relative clearance using nonlinear mixed effects modeling: influence of drug-drug interaction and patient characteristics. Reviewed International journal

Journal of Clinical Pharmacology   37 ( 12 )   1160 - 1167   1997.12

Cell cycle-dependent chronotoxicity of irinotecan hydrochloride in mice. Reviewed International journal

Ohdo, S., Makinosumi, T., Ishizaki, T., Yukawa, E., Higuchi, S., Nakano, S., Ogawa, N.

Journal of Pharmacology and Experimental Therapeutics   283 ( 3 )   1383 - 1388   1997.12

Chronotoxicity of methotrexate in mice and its relation to circadian rhythm of DNA synthesis and pharmacokinetics. Reviewed International journal

Ohdo, S., Inoue, K., Yukawa, E., Higuchi, S., Nakano, S., Ogawa, N.

Japanese Journal of Pharmacology   75 ( 3 )   283 - 290   1997.11

Chronopharmacological study of interferon-α in mice. Reviewed International journal

283 ( 1 )   259 - 264   1997.10

Detection of carbamazepine-induced changes in valproic acid relative clearance in man by simple pharmacokinetic screening. Reviewed International journal

Yukawa, E., Honda, T., Ohdo, S., Higuchi, S., Aoyama, T.

Journal of Pharmacy and Pharmacology   49 ( 8 )   751 - 756   1997.8

Utility of a rectal suppository containing the antiepileptic drug zonisamide. Reviewed International journal

Nagatomi, A., Mishima, M., Tsuzuki, O., Ohdo, S., Higuchi, S.

Biological Pharmaceutical Bulletin   20 ( 8 )   892 - 896   1997.8

Circadian rhythm of fever induced by interferon-α in mice. Reviewed International journal

61 ( 8 )   PL95 - PL100   1997.6

Chronopharmacological study of Ke-Si-To in mice. Reviewed International journal

Ogawa, N., Ohdo, S., Song, J.G., Higuchi, S.

Life Sciences   60 ( 23 )   2091 - 2098   1997.5

Population-based investigation of relative clearance of digoxin in japanese patients by multiple trough screen analysis: an update. Reviewed International journal

Yukawa, E., Honda, T., Ohdo, S., Higuchi, S., Aoyama, T.

Journal of Clinical Pharmacology   37 ( 2 )   92 - 100   1997.2

Influence of the lighting schedule on the toxicity of doxorubicin in chick embryos. Reviewed International journal

Yoshiyama Y., Sugiyama, T., Miyazaki, H., Shimada, H., Ohdo, S.

Alternatives to Animal Testing and Experimentation   1997.2

Influence of feeding schedule on the chronopharmacological aspects of sodium valproate in mice. Reviewed International journal

Ohdo, S., Ogawa, N., Nakano, S., Higuchi, S.

Journal of Pharmacology and Experimental Therapeutics   278 ( 1 )   74 - 81   1996.7

Chronotoxicity of sodium valproate in pregnant mouse and embryo. Reviewed International journal

Ohdo, S., Watanabe, H., Ogawa, N., Yoshiyama, Y., Sugiyama,T.

Japanese Journal of Pharmacology   70 ( 3 )   253 - 258   1996.3

Influence of a circadian-stage-dependent dosing schedule on the pharmacokinetics of isepamicin in humans. Reviewed International journal

Yoshiyama, Y., Kobayashi, T., Ohdo, S., Ogawa, N., Bergeron, M.G., Labrecque, G., Beauchamp, D.,Nakano, S.

Journal of Infection and Chemotherapy   1996.2

Basis for dosing time-dependent changes in the ocular and systemic absorption of topically applied timolol. Reviewed International journal

Lee, V.H.L., Yamahara, H., Gurny, R., Sintzel, M.B., Martenet M., Gex-Fabry, M., Balant, L., Ohdo, S., Podder S.K.

Journal of Ocular Pharmacology and Therapeutics   1996.2

Circadian rhythm of the embryotoxicity induced by sodium valproate in mice. Reviewed International journal

Ohdo, S., Watanabe, H., Ogawa, N., Yoshiyama, Y., Sugiyama,T.

European Journal of Pharmacology   293 ( 3 )   281 - 285   1995.10

Chronopharmacological study of acetylsalicylic acid in mice. Reviewed International journal

Ohdo, S., Ogawa, N., Song, J.G.

European Journal of Pharmacology   293 ( 2 )   151 - 157   1995.7

Manipulation of lighting schedule can modify the pharmacological effects of theophylline in chick embryos. Reviewed International journal

Yoshiyama, Y., Sugiyama, T., Kubota, N., Miyazaki, H., Saito, K., Tomonaga, F., Shimada, H., Ohdo, S.

Biological Pharmaceutical Bulletin   18 ( 5 )   776 - 778   1995.5

Alteration in circadian rhythm of plasma corticosterone in rats following sociopsychological stress induced by communication box. Reviewed International journal

Ishikawa, M., Ohdo, S., Watanabe, H., Hara, C., Ogawa, N.

Physiology and Behavior   1995.1

Influence of feeding schedule on chronopharmacological aspects of gentamicin in mice. Reviewed International journal

Song, J.G., Ohdo, S., Nakano, S., Ogawa, N.

Chronobiology International   1993.10

Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats. Reviewed International journal

Yoshiyama, Y., Nishikawa, S., Sugiyama, T., Kobayashi, T., Shimada, H., Tomonaga, F., Ohdo, S., Ogawa, N., Nakano, S.

Antimicrobial Agents and Chemotherapy   1993.9

Chronotoxicity and chronopharmacokinetics of methotrexate in mice: modification by feeding schedule. Reviewed International journal

Song, J.G., Nakano, S., Ohdo, S., Ogawa, N.

Japanese Journal of Pharmacology   1993.8

Effects of social isolation on pentobarbital activity in mice: Relationship to racemate levels and enantiomers levels in brain. Reviewed International journal

Watanabe, H., Ohdo, S., Ishikawa, M., Ogawa, N.

Journal of Pharmacology and Experimental Therapeutics   1992.12

Light-dark variations in ocular timolol concentrations following topical solution instillation in the pigmented rabbit. Reviewed International journal

Ohdo, S., Zhu, J., Lee V.H.L.

Life Sciences   1992.12

Circadian changes of valproate kinetics depending on meal condition in man. Reviewed International journal

Ohdo, S., Nakano, S., Ogawa, N.

Journal of Clinical Pharmacology   1992.9

Plasma corticosterone response of rats with socio-psychological stress in communication box. Reviewed International journal

Ishikawa, M., Hara, C., Ohdo, S., Ogawa, N.

Physiology & Behavior   1992.9

Chronopharmacological study of valproic acid in mice: Comparison of oral and rectal administration. Reviewed International journal

Yoshiyama, Y., Nakano, S., Ohdo, S., Ogawa, N.

Journal of Pharmacobio Dynamics   1992.8

Pharmacokinetic basis for nonadditivity of intraocular pressure lowering in timolol combinations. Reviewed International journal

Lee, V.H.L., Luo, A.M., Li, S., Podder, S.K., Chang, J.S.C., Ohdo, S., Grass, G.M.

Investigative Ophthalmology & Visual Science   1991.10

Improving the ocular to systemic ratio of topical timolol by varying the dosing time. Reviewed International journal

Ohdo, S., Grass, G.M., Lee, V.H.L.

Investigative Ophthalmology & Visual Science   1991.9

Chronopharmacokinetics of valproic acid following constant-rate administration in mice. Reviewed International journal

Ohdo,S.,Nakano,S.,Ogawa,N.

Chronobiology International   1991.2

An influencing factor to predict plasma valproate concentrations: Circadian stage-dependent kinetics. Reviewed International journal

Ohdo,S.,Nakano,S.,Ogawa,N.

Japanese Journal of Clinical Pharmacology and Therapeutics   1990.12

Time-dependent in diazepam kinetics after repeated doses in man. Reviewed International journal

Watanabe,H.,Nakano,S.,Ohdo,S.,Takaoka,N.,Ogawa,N.

Japanese Journal of Clinical Pharmacology and Therapeutics   1990.9

Chronotoxicity of sodium valproate and its mechanisms in mice: Dose-concentration-response relationship. Reviewed International journal

Ohdo,S.,Nakano,S.,Ogawa,N.

Chronobiology International   1989.3

Alteration in hypnotic effect of pentobarbital following repeated agonistic confrontations in mice. Reviewed International journal

Ohdo,S.,Yoshimura,H.,Ogawa,N.

Psychopharmacology   1989.1

Chronopharmacological study of sodium valproate in mice: Dose-concentration-response relationship. Reviewed International journal

Ohdo,S.,Nakano,S.,Ogawa,N.

Japanese Journal of Pharmacology   1988.5

体内時計の分子機構を基盤にした新規時間治療の開発. 体内時計の科学と産業応用（柴田重信　監修、シーエムシー出版）28-37, 2011.　5月

大戸茂弘.（ Role： Joint author）

シーエムシー出版  2011.5 

Perspective 薬剤学　（大戸茂弘 編集、京都廣川書店）3月, 2011.

大戸茂弘 編集（ Role： Edit）

2011.3 

コンパス分子生物学　－創薬・テーラーメイド医療に向けて－（荒牧弘範、大戸茂弘 編集、南江堂）2月, 2010.

荒牧弘範、大戸茂弘 編集（ Role： Edit）

2010.2 

薬物とリズム. 時間生物学事典（石田真理雄、本間研一 編集、朝倉書店）258-261, 2008.

大戸茂弘.（ Role： Joint author）

朝倉書店  2008.3 

産総研ブックス　きちんとわかる時計遺伝子　 「薬を飲む時間と体内時計」　（産業技術総合研究所、白日社）143-155, 2007.

大戸茂弘.（ Role： Joint author）

産業技術総合研究所、白日社  2007.12 

時間治療の基礎と実践（大戸茂弘、吉山友二　監修、丸善株式会社）(癌　47-54, 2007）.

大戸茂弘.（ Role： Supervisor (editorial)）

丸善株式会社  2007.9 

時間治療の基礎と実践（大戸茂弘、吉山友二　監修、丸善株式会社）(生体リズムと創薬・医薬品適正使用. 2-10, 2007).

大戸茂弘.（ Role： Supervisor (editorial)）

丸善株式会社  2007.9 

時間治療の基礎と実践（大戸茂弘、吉山友二　監修、丸善株式会社）(時間薬物体内動態とTDM・DDS. 11-21, 2007).

大戸茂弘.（ Role： Supervisor (editorial)）

丸善株式会社  2007.9 

時間治療の基礎と実践（大戸茂弘、吉山友二　監修、丸善株式会社）(時計遺伝子と時間治療の今後の展開.22-30, 2007).

大戸茂弘.（ Role： Supervisor (editorial)）

丸善株式会社  2007.9 

Chronobiology in cancer therapies. In About Cancer in Africa. Edited by Adama, LY and David, KHAYAT.

Eriguchi, M., Cornelissen, G., Halberg, F., Hisa, T., Ohdo, S., Otsuka, K., Takeda, Y., Yanagie, H.（ Role： Joint author）

Institute National Cancer, Paris France  2006.12 

生体リズムと時間治療（日本薬学会　編、薬事日報社）2006.

吉山友二、大戸茂弘.（ Role： Joint author）

日本薬学会　編、薬事日報社  2006.3 

時間薬理学.　臨床薬理学（日本臨床薬理学会 編）

大戸茂弘、吉山友二、熊谷雄治.（ Role： Joint author）

医学書院  2003.4 

がんの時間薬物治療. Technical term　緩和医療（下山直人、向山雄人、山脇成人　編集）

大戸茂弘.（ Role： Sole author）

先端医学社  2002.8 

アプライドセラピューティクス4（緒方宏泰、越前宏俊、増原慶壮　編集）

大戸茂弘（ Role： Joint translator）

テクノミクス  2001.8 

時間薬物体内動態とDDS. 時間薬理学（小川暢也 編集、吉山友二、大戸茂弘　編集協力）

大戸茂弘.（ Role： Sole author）

朝倉書店  2001.1 

時間薬物治療の将来. 時間薬理学（小川暢也 編集、吉山友二、大戸茂弘　編集協力）

大戸茂弘.（ Role： Sole author）

朝倉書店  2001.1 

眼科疾患の時間治療. 時間薬理学（小川暢也 編集、吉山友二、大戸茂弘　編集協力）

中野重行、石井陽子、梅月恵美、大戸茂弘.（ Role： Joint author）

朝倉書店  2001.1 

癌の時間治療. 時間薬理学（小川暢也 編集、吉山友二、大戸茂弘　編集協力）

大戸茂弘.（ Role： Sole author）

朝倉書店  2001.1 

薬剤投与における有効量と中毒量. 薬剤による副作用と中毒

小川暢也,高岡伸行,大戸茂弘.（ Role： Joint author）

株式会社ミクス  1989.7 

時間薬理と時間栄養の接点 Invited

大戸茂弘

国立研究開発法人、医薬基盤・健康・栄養研究所、国立健康・栄養研究所、シナジーセミナー  2019.6 

生体リズムと時空間解析 Invited

大戸茂弘

メタボロミクスワークショップ  2018.12 

体内時計の分子機構を基盤にした創薬・育薬 Invited

大戸茂弘

日本レチノイド研究会第29回学術集会  2018.10 

Chronochemical biology for cell-based chemical screening strategy to identify small molecules. Invited

Shigehiro Ohdo

2018 (The 4th) International Conference on Toxicity Testing Alternatives and Translational Toxicology, The 2nd Asian Congress on Alternatives  2018.10 

Chronopharmacology based on circadian clock-regulated xenobiotic transporters. Invited International conference

Koyanagi S, Matunaga N, Ohdo S

2018 International meeting on 22nd MOD and 33rd Annual Meeting of JSSX.  2018.10 

The role of molecular clock in the alterations of hepatic metabolism in chronic kidney disease. Drug metabolism around the clock (the influence of circadian rhythm on drug metabolism) Invited International conference

Shigehiro Ohdo, Naoya Matsunaga, Satoru Koyanagi.

2018 International meeting on 22nd MOD and 33rd Annual Meeting of JSSX.  2018.10 

体内時計の分子機構を基盤とした難治性乳がんの新規治療法の開発 Invited

松永直哉、大戸茂弘

第25 回 日本時間生物学会学術大会  2018.10 

生体リズムと時間薬理学、薬学による眼科薬理の進歩 Invited

大戸茂弘

第38回日本眼薬理学会  2018.9 

大戸茂弘、「グリーンファルマを基盤にした創薬オープンイノベーションの推進」、九州大学日本橋サテライト開所記念式典　「ライフサイエンス領域における産学官連携の取り組み」報告Ⅱ（日本橋）、2018年2月15日

大戸 茂弘

九州大学日本橋サテライト開所記念式典　「ライフサイエンス領域における産学官連携の取り組み」  2018.2 

Shigehiro Ohdo 、Chronopharmacology and chronopharmaceutics focused on biological rhythm、The Fourth National Academic Conference of Sleep, Chronobiology and Neuropsychopharmacology by the Chinese Sleep Research Society (CSRS)、（Shanghai Medical College of Fudan University, Shanghai, China.）、December 16-17, 2017 Invited

2017.12 

大戸茂弘、「アカデミア創薬における臨床薬理学の役割：　薬を創り育てる」 第38回日本臨床薬理学会学術総会（シンポジウム15）（横浜）、2017年12月8日 Invited

大戸 茂弘

第38回日本臨床薬理学会学術総会（シンポジウム15）（横浜）、2017年12月8日  2017.12 

大戸茂弘、生体リズムと創薬育薬　ー腎臓病と合併症ー、第11回日本腎臓病薬物療法学会学術集会・総会2017（教育講演7）（福岡）、2017年10月1日 Invited

大戸 茂弘

第11回日本腎臓病薬物療法学会学術集会・総会2017（教育講演7）（福岡）、2017年10月1日  2017.10 

大戸茂弘、体内時計と薬の関係を利用した時間治療、第37回日本歯科薬物療法学会学術大会（名古屋）、2017年6月17―18日 Invited

大戸 茂弘

第37回日本歯科薬物療法学会学術大会（名古屋）、2017年6月17―18日  2017.6 

大戸茂弘、時間薬理学を基盤にした創薬と育薬、第33回大分大学眼科研究会（大分）、2017年2月18日 Invited

大戸 茂弘

第33回大分大学眼科研究会（大分）、2017年2月18日  2017.2 

大戸茂弘.　がんの時間治療. シンポジウム 「時間治療の現状」　第37回日本臨床薬理学会　（鳥取）2016年12月1－3日 Invited

大戸 茂弘

第37回日本臨床薬理学会　（鳥取）2016年12月1－3日  2016.12 

大戸　茂弘　時間薬理学を基盤にした創薬と育薬、シンポジウム「時間治療の動向と成長戦略2016」、第23回日本時間生物学会学術大会（名古屋）2016年11月12-13日 Invited

大戸 茂弘

第23回日本時間生物学会学術大会（名古屋）2016年11月12-13日  2016.11 

大戸茂弘、患者にやさしい生体リズムにマッチした時間治療、第49回日本漢方交流会　全国学術総会　福岡大会（福岡）2016年10月9日 Invited

大戸 茂弘

第49回日本漢方交流会　全国学術総会　福岡大会（福岡）2016年10月9日  2016.10 

Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo. 　A pathophysiological framework of circadian clock in chronic kidney disease. The 2nd HU-TMU-KU Joint Symposium for Pharmaceutical Sciences 2016/9/5 (Taipei, Taiwan) Invited International conference

大戸 茂弘

2016.9 

大戸茂弘、生体リズムを基盤にした創薬・育薬、教育講演、第33回日本TDM学会・学術大会（栃木）2016年5月28日 Invited

大戸 茂弘

第33回日本TDM学会・学術大会（栃木）2016年5月28日  2016.5 

Shigehiro Ohdo、Chronopharmacology of antitumor drugs focused on biological clock 、Chronopharmacology in cancer, shift work sleep disorder and beyond　（Chair: Francis Lévi）SRBR 2016 、May 22, 2016 Invited International conference

大戸 茂弘

SRBR 2016 、May 22, 2016  2016.5 

大戸茂弘、生体リズムを基盤にした創薬・育薬、特別講演、第64回質量分析総合討論会（大阪）2016年5月19日 Invited

大戸 茂弘

第64回質量分析総合討論会（大阪）2016年5月19日  2016.5 

鶴留　優也、小柳　悟、松永　直哉、大戸　茂弘. 足場タンパク質(NHERF1)の発現リズムに基づいた肝細胞膜トランスポーターの機能制御. 薬剤学会第31年会（岐阜市）. 2016年5月18日 Invited

大戸 茂弘

薬剤学会第31年会（岐阜市）. 2016年5月18日  2016.5 

松永　直哉，小柳　悟，大戸　茂弘.がんの時間生物学・時間治療.日本薬学会 第136年会（横浜）、2016年3月26日. Invited

大戸 茂弘

日本薬学会 第136年会（横浜）、2016年3月26日.  2016.3 

大戸　茂弘. 特別講演2「患者に優しい生体リズムにマッチしたクロノセラピィー」第48回日本薬剤師会学術大会(鹿児島)　2015年11月22日 Invited

大戸 茂弘

第48回日本薬剤師会学術大会  2015.11 

大戸　茂弘.教育講演8「がんの時間薬理学を考えた効果的な緩和薬物治療」、第9回日本緩和医療薬学会年会 (横浜)　2015年10月4日 Invited

大戸 茂弘

第9回日本緩和医療薬学会年会  2015.10 

大戸　茂弘. 時間薬理学―患者さんにやさしい時間治療.第26回日本緑内障学会　招待講演 (名古屋)、2015年9月12日 Invited

大戸 茂弘

第26回日本緑内障学会  2015.9 

大戸　茂弘. 分子時計を基盤とした創薬・育薬。藤井節郎先生記念シンポジウム(福岡)　2015年6月20日 Invited

大戸 茂弘

藤井節郎先生記念シンポジウム  2015.6 

大戸　茂弘. 時間制御による新たな創薬ストラテジ-,日本薬剤学会 創立30周年記念シンポジウム 創薬・創剤の新たな方向性を探る,日本薬剤学会第30年会 (長崎)　2015年5月20日 Invited

大戸 茂弘

日本薬剤学会第30年会  2015.5 

大戸 茂弘, 分子時計を基盤にした炎症および癌に対する創薬、シンポジウムS04グリーンファルマ研究の最前線～難治性疾患克服への挑戦～,日本薬学会第135年会　（神戸）　2015年3月26日 Invited

大戸 茂弘

日本薬学会第135年会  2015.3 

大戸茂弘.講演1：からだの時計と薬、市民公開講座「時と睡眠と薬」、第88回 日本薬理学会年会 （名古屋）2015年3月21日 Invited

大戸 茂弘

第88回 日本薬理学会年会  2015.3 

松永直哉、小柳 悟、大戸茂弘.　慢性腎不全時の腎-肝-腎連関における分子時計の影響、 ワークショップ2 in vivo循環機能評価法, 第88回日本薬理学会年会（名古屋）2015年3月19日 Invited

大戸 茂弘

第88回日本薬理学会年会（名古屋）2015年3月19日  2015.3 

大戸茂弘. Chronopharmacology of antitumor drugs focused on biological clock Symposium 17“Chronopharmacology－Present and Future”第88回 日本薬理学会年会 （名古屋）2015年3月19日 Invited

大戸 茂弘

第88回 日本薬理学会年会  2015.3 

Ohdo S, Chronopharmacology and chronopharmaceutics focused on biological rhythm Taipei　Medical University - Kyushu University International Joint Seminar　2014 November 14 Invited

大戸 茂弘

Taipei　Medical University - Kyushu University International Joint Seminar  2014.11 

大戸茂弘「時間薬理学と時間栄養学」、第3回日本くすりと糖尿病学会学術集会、教育講演6、2014年11月3日 Invited

大戸 茂弘

第3回日本くすりと糖尿病学会学術集会  2014.11 

Ohdo S,　CHRONO-DRUG AND DELIVERY SYSTEM: RHYTHM MONITORING, DISRUPTION AND MANIPULATION ISSX-JSSX Ｓｙｍｐｏｓｉｕｍ 3：Chronopharmacological strategy for Drug Discovery and Evolution, Co-Chairs: Shigehiro Ohdo, Damjana Rozman,2014 October 20 Invited

大戸 茂弘

2014.10 

大戸茂弘、特別講演Ⅰ「体内時計の分子機構を基盤にした創薬・育薬：薬物輸送と薬物送達」創剤フォーラム（金沢）第20回シンポジウム、2014年9月19日 Invited

大戸 茂弘

創剤フォーラム  2014.9 

Ohdo S. Chronopharmacology and chronopharmaceutics focused on biological clock Pusan-Kyushu Joint Seminar 2014年8月18日 Invited

大戸 茂弘

2014.8 

セッション4：腫瘍克服のための新規製剤技術とその効果、「抗癌剤と時間薬理学」、第51回　薬剤学懇談会研究討論会（沖縄）2014年6月20日 Invited

大戸 茂弘

第51回　薬剤学懇談会研究討論会  2014.6 

神経障害性疼痛の概日リズム形成メカニズムと鎮痛標的分子の探索 Invited

小柳 悟, 楠瀬直喜, 大戸 茂弘

日本薬学会第134年会  2014.3 

患者に優しい時間薬剤学 Invited

大戸茂弘

PLCM（耕薬）研究会、　第8回シンポジウム[口腔内速崩壊錠等の現状と展望]  2014.1 

概日時計因子ATF4によるトランスポーター発現リズムと抗がん剤感受性の制御 Invited

小柳悟、松永直哉、大戸茂弘

第35回生体膜と薬物の相互作用シンポジウム  2013.11 

時間薬物動態におけるトランスレーショナルリサーチ Invited

小柳悟、松永直哉、大戸茂弘

第20回 日本時間生物学会  2013.11 

分子時計を基盤にした創薬・育薬 Invited

大戸茂弘

日本薬学会九州支部　コロキウム  2013.10 

Molecular mechanism regulating circadian expression of drug metabolism enzymes in human Invited

Koyanagi Satoru, Matsunaga Naoya, Shigehiro Ohdo

2013.10 

Chronopharmacological aspects of transporters Invited

2013.10 

サーカディアンリズムと時間治療 Invited

大戸茂弘

第12回 抗加齢医学の実際2012  2013.9 

がん細胞の薬剤感受性の概日リズム制御メカニズムと投薬のタイミング Invited

大戸茂弘、小柳悟、松永直哉

第86回 日本生化学会  2013.9 

生体リズムとがん化学療法 Invited

大戸茂弘

第20回　薬と医療シンポジウム  2013.8 

部会長講演　医療薬学フォーラム2013　第21回クリニカルファーマシーシンポジウム Invited

大戸茂弘

医療薬学フォーラム2013　第21回クリニカルファーマシーシンポジウム  2013.7 

時間薬理学の現状と将来 Invited

大戸茂弘、小柳悟、松永直哉、

第128回 日本薬理学会関東部会  2013.7 

生体リズムと医薬品 Invited

大戸　茂弘

日本薬剤学会第28年会  2013.5 

生体リズムにマッチしたクロノセラピィー、特別企画シンポジウム2「患者に優しい投与方法」（オーガナイザー：大戸茂弘、辻将央）. Invited

大戸　茂弘　小柳　悟、松永　直哉.

日本薬剤学会第28年会  2013.5 

がん細胞の抗がん剤感受性の日周リズム制御機構 Invited

小柳悟、松永直哉、大戸茂弘.

第86回 日本薬理学会年会  2013.3 

乱れた生活リズムの改善は、発癌を予防し治療効果を改善する　 Invited

大戸茂弘

第19回日本時間生物学会学術大会  2012.9 

体内時計を基盤とした時間薬剤学 Invited

大戸茂弘

日本薬剤学会第37回製剤セミナー  2012.7 

時間薬理学：薬と食事のタイミング　シンポジウム4SY26 「食品の機能性を時間生物学的視点から考える」 Invited

大戸茂弘、小柳悟、松永直哉．

日本農芸化学会2012年度大会  2012.3 

「Chronopharmacology based on molecular clock」トピックス　7：　体内時計と循環器疾患 Invited

大戸茂弘、小柳悟、松永直哉.

第76回日本循環器学会学術集会  2012.3 

分子時計を基盤にした薬物動態の日内変動. Invited

大戸茂弘,　小柳悟、松永直哉.

第32回日本臨床薬理学会  2011.12 

時間薬物送達システム Invited

松永　直哉、小柳　悟、大戸　茂弘.

第18回日本時間生物学会学術大会  2011.11 

分子機構を基盤にした癌の時間薬理 Invited

大戸　茂弘、小柳　悟、松永　直哉.

第13回応用薬理シンポジウム  2011.9 

概日時計の分子機構を基盤にした薬物投与設計と多剤併用療法への応用 Invited

小柳　悟、松永　直哉、大戸　茂弘.

日本薬剤学会第26年会  2011.5 

時間薬物動態：　生体機能の日周リズムと薬物動態 Invited

大戸　茂弘、小柳　悟、松永　直哉.

第58回日本実験動物学会総会  2011.5 

分子時計を基盤にした時間治療.　シンポジウム「生命現象を担う生体分子に着目した創薬と臨床応用」（オーガナイザー：荒牧弘範、前仲勝実）. Invited

大戸茂弘,　小柳悟、松永直哉.

日本薬学会第131年会  2011.3 

消化管におけるトランスポーター発現の日内変動を制御する分子メカニズム Invited

小柳　悟、松永　直哉、大戸　茂弘.

日本薬学会第131年会  2011.3 

時間薬理による副作用低減. シンポジウム「副作用低減のための新しい薬理学的アプローチ」（オーガナイザー：植田真一郎、大石了三）. Invited

大戸茂弘,　小柳悟、松永直哉.

第84回 日本薬理学会年会  2011.3 

創薬･育薬を指向した時間薬剤学的研究. Invited

大戸茂弘.

第28回製剤設計研究会  2010.10 

Basis for dosing time-dependent change in the anti-allodynic effect of gabapentin in mice International conference

Naoki Kusunose, Satoru Koyanagi, Kengo Hamamura, Naoya Matsunaga, Miyako Yoshida, Takahiro Uchida, Shigehiro Ohdo

Neuro2010  2010.9 

Alteration of clock gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease International conference

Neuro2010  2010.9 

Circadian clock-controlled the expression of dopamine receptor DRD2 in caudate-putamen of mice International conference

Eriko Ikeda,Naoya Matsunaga,Akane Hayashi,Satoru Koyanagi,Shigehiro Ohdo

Neuro2010  2010.9 

体内時計の分子機構を基盤にした薬物投与設計.　 シンポジウム1　「薬物療法を支える基礎研究と臨床研究の糸口、進め方と成果の活用」（オーガナイザー：家入一郎、大戸茂弘）． Invited

小柳悟、松永直哉、大戸茂弘.

医療薬学フォーラム2010　第18回クリニカルファーマシーシンポジウム  2010.7 

創薬・育薬を指向した時間薬剤学的研究.　「新技術・新素材が切り拓く薬剤開発」 Invited

大戸茂弘,　小柳悟、松永直哉.　

第47回薬剤学懇談会研究討論会  2010.6 

癌の時間治療と今後の展望.　シンポジウム「体内時計を利用した創薬から治療戦略まで」（オーガナイザー：柴田重信、守屋孝洋）. Invited

大戸茂弘,　小柳悟、松永直哉.

日本薬学会第130年会  2010.3 

時間薬理学とは. シンポジウム「時間薬理学と時間栄養学による新しい治療戦略の開拓」（オーガナイザー：柴田重信、大戸茂弘）. Invited

大戸茂弘,　小柳悟、松永直哉.

第83回 日本薬理学会年会  2010.3 

分子時計を基盤にした創薬･育薬. Invited

大戸茂弘.

第5回DDS熊本シンポジウム  2010.2 

時間治療による薬物治療の最適化. Invited

大戸茂弘.

第24回長崎DDS研究会  2009.12 

創薬・育薬を指向した医療薬学研究の推進に向けて Invited

大戸茂弘.

第71回九州山口薬学大会  2009.11 

Disruptive effect of 5-Fluorouracil on the circadian clock genes: a possible mechanism of the anti-cancer chemotherapeutic induced circadian rhythmic disturbances.　 International conference

Hamdan　AM, Terazono　H, Matsunaga　N, Koyanagi　S, Ohdo　S.

2009.11 

Molecular clock mechanism of drug pharmacokinetics.　 シンポジウム「薬物動態関連遺伝子の発現調節研究の新展開」 Invited

松永直哉、小柳悟、大戸茂弘.

第23回日本薬物動態学会年会  2009.10 

Circadian clock-controlled intestinal expression of multidrug resistance gene mdr1a in mice. International conference

Koyanagi S, Murakami Y, Higashi Y, Matsunaga N, Ohdo S.

Asian Federation for Pharmaceutical Sciences 2009  2009.10 

抗がん剤の時間薬理.　 シンポジウム4「PK/PD解析から見た抗がん剤の効果・副作用」（オーガナイザー：鈴木　洋史、桂　敏也）． Invited

大戸茂弘、松永直哉、小柳悟.

医療薬学フォーラム2009　第17回クリニカルファーマシーシンポジウム  2009.7 

Molecular clock mechanisms of drug metabolism. Symposium “Functional genomics” Invited International conference

2009.6 

薬物・栄養投与の時間治療学的戦略　～体内時計の分子機構を基盤として～. Invited

大戸茂弘.

日本薬学会主催　第10回Pharmaco-Hematologyシンポジウム  2009.6 

Manipulation of feeding schedule can modulate the antiviral effect of Interferon-α. International conference

2008.11 

Chrono-drug delivery of antitumor drugs: molecular clock mechanisms. Invited International conference

Ohdo, S.

Kyushu-Busan International Joint Seminar.  2008.11 

薬物活性リズムの体内時計の分子機構.　 シンポジウム「時間治療の現状」（オーガナイザー：藤村昭夫、大戸茂弘）． Invited

大戸茂弘、松永直哉、小柳悟.

第15回日本時間生物学会学術大会  2008.11 

Dosing-time dependent antitumor effects of Transferrin-Liposome Oxaliplatin (Tf-Lip-L-OHP) in tumor bearing mice. 11th Liposome Research Days Conference. International conference

Ohdo S, Okazaki F, Maruyama K, Matsunaga N, Koyanagi S.

11th Liposome Research Days Conference.  2008.7 

時間薬理学の展望.　 シンポジウム「時間薬理学の最前線」（オーガナイザー：本間研一、宮崎総一郎）． Invited

大戸茂弘.

日本睡眠学会第33回定期学術集会  2008.6 

抗がん剤のPK-PDに影響する要因.　教育講演4． Invited

大戸茂弘.

第25回日本TDM学会・学術大会  2008.6 

Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock gene: a possible mechanism for chemotherapy-induced circadian rhythm disturbances. Invited International conference

Ahmed MH, Ohdo S.

The first japan-egypt international symposium on science and technology. The Japan Egypt Science and Technology Year 2008.  2008.6 

Therapeutic index of methotrexate depends on circadian cycling of tumor necrosis factor-alpha in MRL/lpr and collagen-induced arthritis mice. Invited International conference

To, H., Yoshimatsu, H., Irie, S., Ohbayashi, K., Kitahara, T., Ieiri, I., Ohdo, S., Higuchi, S., Sasaki, H.

Clinical Pharmacology & Therapeutics  2008.4 

Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells. International conference

Koyanagi, S., Takiguchi, T., Tomita, M., Matsunaga, N., Ohdo, S.

2nd World Congress of Chronobiology.  2007.11 

Influence of dosing time on toxicity and efficacy by antirheumatic drug in MRL/lpr and collagen-induce arthritis mice. International conference

To, H., Yoshimatsu, H., Irie, S., Ohbayashi, K., Kanasaki, Y., Ieiri, I., Ohdo, S., Higuchi, S., Sasaki, H.

2nd World Congress of Chronobiology  2007.11 

Chronopharmacological study of hepatotoxicity induced by acetaminopehn in mice. International conference

Matsunaga, N., Ikeda, M., Takiguchi, T., Koyanagi, S., Ohdo, S

2nd World Congress of Chronobiology  2007.11 

Circadian clock-controlled expression of the multidrug resistance gene mdr1a in mouse small intestine. International conference

Ohdo, S., Murakami, Y., Higashi, Y., Matsunaga, N., Koyanagi, S.

2nd World Congress of Chronobiology  2007.11 

Simple and rapid genotyping of D-amino-acid oxidase gene using microchip electrophoresis. International conference

Tojo, Y., Hamase, K., Konno, R., Koyanagi, S., Ashida, Y., Ohdo, S., Zaitsu, K.

10th International Congress on Amino Acids and Proteins (ICAAP)  2007.8 

Circadian clock-controlled expression of the multidrug resistance gene mdr1a in mouse small intestine. International conference

Ohdo, S., Murakami, Y., Higashi, Y., Matsunaga, N., Koyanagi, S.

4th World Conference on Drug Absorption, Transport and Delivery.  2007.6 

Chronopharmacology of imatinib in mice. Invited

Ohdo, S.

The 66th Annual Meeting of the Japanese Cancer Association.  2007.10 

Chronopharmacology of antitumor drugs in mice. Invited International conference

Ohdo, S.

The 3rd Asian Symposium for Pharmaceutical Sciences.  2007.10 

Therapeutic index by combination of adriamycin and docetaxel depends on dosing time in mice. Invited International conference

To, H., Ohdo, S., Sasaki, H., Higuchi, S., Fujimura, A.

2nd World Congress of Chronobiology.  2007.11 

Chronopharmacology of antitumor drugs: molecular clock mechanisms Invited International conference

Ohdo, S.

2nd World Congress of Chronobiology.  2007.11 

体内時計の分子機構を基盤にした投薬タイミング. Invited

大戸茂弘.

BMB2007　（第30回日本分子生物学会年会、第80回日本生化学会大会　合同大会）  2007.12 

体内時計の分子機構を基盤にした癌の時間薬剤学 Invited

大戸茂弘

第7回 九州がんフォーラム （福岡） 2008年2月8日  2008.2 

薬物活性リズムの転写制御機構と時間薬剤学. Invited

大戸茂弘.

日本薬学会第128年会  2008.3 

生体リズムと薬物・栄養の投与タイミング（特別教育講演）.　シンポジウム「専門認定薬剤師の活躍と再教育」（オーガナイザー：佐藤健太郎）. Invited

大戸茂弘.

第22回日本静脈経腸栄養学会）  2007.2 

Alteration in hypnotic effect of pentobarbital following agonistic confrontations in mice International conference

Yoshimura, H., Ohdo, S., Ogawa, N.

3rd European conference international society for research on aggression  1985.9 

Circadian stage-dependent changes in diazepam and valproate kinetics in man: A single and repetitive administration study. International conference

Nakano, S., Watanabe, H., Ohdo, S., Ogawa, N.

Second international conference of chronopharmacology: "biological rhythms and medications"  1986.3 

Manipulation of feeding schedule can modify the circadian rhythms of toxicity and kinetics of theophylline in mice. International conference

Nakano, S., Ohdo, S., Ogawa, N.

Third international conference of chronopharmacology.  1988.3 

Circadian stage-dependent changes in valproate kinetics and application to dosage adjustment. International conference

Ohdo, S., Nakano, S., Ogawa, N.

Clinical chronopharmacology satellite symposium to the IVth world conference on clinical pharmacology & therapeutics  1989.7 

Effects of dosing regimen of an oral hypoglycemic drug, gliclazide, on blood glucose and insulin levels. International conference

Nakano, S., Iegushi M, Ohdo, S., Fujii, Y., Fukuda, T., Ogawa, N.

IV world conference on clinical pharmacology & therapeutics.  1989.7 

Chronopharmacological study of sodium valproate in man and mice. Invited International conference

Ohdo, S.

Pharmaceutical Seminar in University of Southern California  1990.1 

Ocular chronopharmacology in the pigmented rabbit: ocular timolol concentrations are dependent on the time of drop instillation. International conference

Ohdo, S., Podder, S., Lee, V.H.L.

The association for research in vision and ophthalmology (ARVO).  1990.4 

Maximizing the ratio of ocular to systemic absorption of topically applied timolol in the pigmented rabbit by varying the time of drop instillation. International conference

Lee, V.H.L., Ohdo, S., Podder, S., Shih, R.L.

17th international symposium on controlled release of bioactive materials  1990.7 

Ocular chronopharmacokinetics in the pigmented rabbit: ocular timolol concentrations are dependent on the time of instillation of timolol and O-1'-methylcyclopropanoyl timolol solutions. International conference

Ohdo, S., Kompella, U., Shih, R.L., Lee, V.H.L.

American association of pharmaceutical scientists (AAPS)  1990.11 

Influence of iride pigmentation on the diurnal variations in timolol concentrations in the rabbit eye. The association for research in vision and ophthalmology (ARVO). International conference

Ohdo, S., Lee, V.H.L.

The association for research in vision and ophthalmology (ARVO).  1991.4 

Varying the dosing time to further improve the ocular:systemic ratio of O-1'-methylcyclopropanoyl timolol in the pigmented rabbit. International conference

Kompella, U., Ohdo, S., Gurny, R., Martenet, M.,Bundgaard, H., Lee, V.H.L.

The association for research in vision and ophthalmology (ARVO)  1991.4 

Influence of housing condition on pentobarbital response and its kinetics in mice. International conference

Watanabe, H., Ohdo, S., Ogawa, N.

Pan pacific VI conference  1991.5 

小川暢也,大戸茂弘.時間薬理学の立場からみた用量・濃度・反応関係. Invited

小川暢也,大戸茂弘.

第7回 日本DDS学会  1991.7 

時間薬理学の基礎と応用 Invited

大戸茂弘.

第10回日本医薬品卸勤務薬剤師会  1992.2 

Chronopharmacokinetic study of isepamicin in man. Vth world conference on clinical pharmacology and therapeutics. International conference

Yoshiyama, Y., Nishikawa, S., Kobayashi, T., Tomonaga, F., Ohdo, S., Ogawa, N., Nakano, S.

Vth world conference on clinical pharmacology and therapeutics.  1992.7 

Circadian changes of valproate kinetics depending on meal condition in man International conference

Ohdo, S., Nakano, S., Ogawa, N.

Vth world conference on clinical pharmacology and therapeutics  1992.7 

The influence of circadian-stage dependent dosing schedule on the nephrotoxicity and pharmacokinetics of isepamicin in rats. Fifth international conference of chronopharmacology. "Biological rhythms and medications". International conference

Yoshiyama, Y., Nishikawa, S., Sugiyama, T., Kobayashi, T., Shimada, H., Tomonaga, F., Ohdo, S., Ogawa, N., Nakano, S.

Fifth international conference of chronopharmacology. "Biological rhythms and medications"  1992.7 

Influence of dosing time on the embryotoxicity of valproic acid in mice. International conference

Ohdo, S., Watanabe, H., Ogawa, N., Yoshiyama, Y.

Fifth international conference of chronopharmacology. "Biological rhythms and medications"  1992.7 

Chronopharmacology. Invited International conference

Ohdo, S.

The Pharmaceutical Society of China.  1992.10 

Chronopharmacology. Invited International conference

Ohdo, S.

The Pharmaceutical Society of China  1992.10 

Manipulation of feeding schedule can modify the circadian rhythm of toxicity of miconazole in mice. International conference

Yoshiyama, Y., Atsuta, K., Nishikawa, S., Kobayashi, T., Tomonaga, F.,Ohdo, S., Ogawa, N., Nakano, S.

Pan pacific VII conference.  1993.5 

Circadian rhythm of human rectum temperature and its effect on melting time of rectal suppository. International conference

Yoshiyama, Y., Kobayashi, T., Tomonaga, F., Ohdo, S., Ogawa, N., Nakano, S.

XXI conference International society for chronobiology.  1993.7 

Chronopharmacological study of ke-si-to in mice. International conference

Ogawa, N., Ohdo, S., Song, J.G.

XXI conference International society for chronobiology.  1993.7 

Influence of dosing time on the pharmacokinetics and nephrotoxicity of isepamicin in man and rats. International conference

Yoshiyama, Y., Nishikawa, S., Sugiyama, T., Kobayashi, T., Shimada, H., Tomonaga, F.,Ohdo, S., Ogawa, N., Nakano, S.

World congress of pharmacy and pharmaceutical sciences 1993. 53. International congress of pharmaceutical sciences.  1993.9 

Mnipulation of lighting schedule can modify the pharmacological effects of theophylline in chick embryos. International conference

Yoshiyama, Y., Sugiyama, T., Kubota, N., Miyazaki, H., Saito,K., Tomonaga, F., Shimada, H., Ohdo, S.

World congress on alternatives and animal use in the life sciences.  1993.11 

Influence of feeding schedule on chronopharmacological aspects of ke-si-to in mice. International conference

Song, J.G., Ohdo, S., Ogawa, N.

V Chinese society of clinical pharmacology and therapeutics  1993.11 

Dosing time influence on the ocular and systemic absorption of topically　applied beta adrenergic antagonists in the pigmented rabbit. International conference

1994.5 

Chronopharmacological study of Ke-Si-To in mice; the role of Ke-Si-To ingredients. Sixth international conference of chronopharmacology. "Biological rhythms and medications". International conference

Ogawa, N., Ohdo, S., Song, J.G.

Sixth international conference of chronopharmacology. "Biological rhythms and medications"  1994.7 

Influence of feeding schedule on chronopharmacological study of aspirin in mice. International conference

Ohdo, S., Higuchi, S., Song, J.G., Ogawa, N., Yoshiyama, Y., Sugiyama, T.

Sixth international conference of chronopharmacology. "Biological rhythms and medications".  1994.7 

Influence of lighting schedule on the toxicity of adriamycin in chick embryos. International conference

Nishikawa, S., Yoshiyama, Y., Sugiyama, T., Kubota, N., Miyazaki, H.,Saito, K., Kobayashi, T., Tomonaga, F., Shimada, H., Ohdo, S., Ogawa, N.

Sixth international conference of chronopharmacology. "Biological rhythms and medications".  1994.7 

Chronopharmacology of cancer. Invited International conference

Ohdo, S.

The sixth Meeting of Mathematical Pharmacology  1994.8 

Time-dependent changes in ethanol-induced gastric ulcer and implication for drug therapy with noradrenaline or prostaglandin medication in rats. International conference

Yoshiyama, Y., Atsuda, K., Tomonaga, F., Ohdo, S.

8th international conference on ulcer research  1994.11 

抗腫瘍薬の薬効リズムに及ぼす細胞動態と薬物動態の影響. Invited

大戸茂弘,樋口駿

第69回 日本薬理学会年会  1996.3 

Chronopharmacokinetics of valproic acid following constant-rate administration in mice; modification by feeding schedule. International conference

Ohdo, S., Yukawa, E., Higuchi, S., Nakano, S., Ogawa, N.

23th international symposium on controlled release of bioactive materials.  1996.7 

Chronopharmacology of sodium valproate in mice; modification by feeding schedule. International conference

Ogawa, N., Ohdo, S., Nakano, S., Higuchi, S.

Seventh international conference on chronopharmacology and chronotherapeutics.  1996.9 

Chronopharmacological study of aspirin in mice: dose-concentration-response relationship. International conference

Song, J.G., Ohdo, S., Ogawa, N.

The fourth japan-china joint meeting on pharmacology.  1996.9 

抗腫瘍薬の時間薬理. シンポジウム「時間薬理と治療」 Invited

大戸茂弘,樋口駿.

第18回 日本臨床薬理学会  1997.12 

抗腫瘍薬の時間薬物治療への指向；細胞周期と投薬タイミング Invited

大戸茂弘.

第35回薬剤学懇談会研究討論会  1998.7 

Chronopharmacological study of valproic acid in mice: dose-concentration and concentration-response relationships. International conference

Ohdo, S., Nakano, S., Ogawa, N.

XVlll international conference of chronobiology  1998.7 

時間薬理学的側面からの投薬指針；生体リズムと投薬タイミング. Invited

大戸茂弘.

第17回生物薬剤学研究会  1999.6 

Chronopharmacology of interferon-α in mice. International conference

1999.8 

Chronopharmacology of granulocyte colony-stimulating factor in mice.

Ogawa, N., Ohdo, S., Yukawa, E., Higuchi, S., Yoshiyama, Y., Nakano, S.

Eighth international conference on chronopharmacology and chronotherapeutics.  1999.8 

精神神経疾患の時間治療の可能性. Invited

大戸茂弘.

第9回日本臨床精神神経薬理学会  1999.10 

癌の時間治療. Invited

大戸茂弘.

日本薬学会第120年会  2000.3 

生体リズムと時間治療：現状と将来. Invited

大戸茂弘.

日本麻酔学会第47回大会  2000.4 

癌の時間治療. Invited

大戸茂弘.

第12回がん治療と幹細胞移植セミナー  2000.10 

The effect of timing on tolerance to cataleptic responses of haloperidol following repeated administration in mice. International conference

Viyoch, J.,Ohdo, S., Yukawa, E., Higuchi, S.

PAC/FAPA conference  2000.10 

薬物相互作用と臨床薬物動態 Invited

大戸茂弘

日本薬学会第121年会  2001.3 

抗腫瘍薬の時間薬理. Invited

大戸茂弘.

第74回 日本薬理学会年会  2001.3 

Chronopharmacology of analgesic effect and tolerance induced by morphine in mice. International conference

Yoshida, M.,Ohdo, S., Takane, H., Tomiyoshi, Y., Yukawa, E., Higuchi, S.

61th PAC/FAPA conference.  2001.9 

時間薬理学に基づいた投薬設計 Invited

大戸茂弘

第1回自己ー非自己認識研究会  2001.10 

時間薬物治療の現状と将来. Invited

大戸茂弘.

大分統計談話会・第24回会合  2001.10 

時間薬理学を利用した薬物治療（インターフェロン療法を含む） Invited

大戸茂弘.

福岡肝臓リサーチ研究会  2001.11 

抗がん剤の副作用軽減への時間薬理学の応用 Invited

大戸茂弘.

第8回医療薬学公開シンポジウム  2001.11 

癌の時間治療. Invited

大戸茂弘.

第2回バイオサイエンス研究会  2002.1 

時間薬物治療の医薬品適正使用への応用. Invited

大戸茂弘.

第486回福岡地区勤務薬剤師会  2002.1 

癌の時間薬物治療 Invited

大戸茂弘.

第5回臨床薬理瀬戸内カンファレンス  2002.2 

生体リズムを基盤にした新規時間治療法の開発に関する基礎的研究. Invited

大戸茂弘

日本薬学会第122年会  2002.3 

医薬品適正使用を指向した薬物治療の個別化. Invited

大戸茂弘.

日本薬学会第122年会  2002.3 

薬物相互作用と薬物動態学. Invited

大戸茂弘.

第75回 日本薬理学会年会  2002.3 

時間薬物治療の現状と将来. Invited

大戸茂弘.

第24回日本生物学的精神医学会  2002.4 

時間治療の現状と今後の展開 Invited

大戸茂弘

第27回西日本薬剤学研究会  2002.7 

時間薬物治療 Invited

大戸茂弘

第27回製剤セミナー  2002.7 

時間治療の今後の展開 Invited

大戸茂弘

第10回クリニカルファーマシーシンポジウム  2002.7 

薬物療法への時間薬理学の応用 Invited

大戸茂弘

第12回日本医療薬学会  2002.10 

Cancer chronotherapy based on biological rhythm. Invited International conference

Ohdo S.

The 3rd international symposium: workshop on chronoastrobiology and chronotherapy.  2002.11 

時間治療の現状と今後の展開 Invited

大戸茂弘

第32回臨床薬物研究会  2002.11 

The influences of pharmacokinetics and pharmacodynamics on diurnal variation in catalepsy response to haloperidol in mice. International conference

Viyoch, J.,Ohdo, S., Higuchi, S.

AAPS  2002.11 

生体リズムを基盤にしたがんの時間治療 Invited

大戸茂弘

第6回 九州がんフォーラム  2002.12 

生体リズムを基盤にしたインターフェロンの時間治療の可能性 Invited

大戸茂弘

第4回 九州血液腫瘍研究会  2003.2 

臨床薬効評価の視点より　ー集団から個の治療に向けてー. Invited

大戸茂弘.

日本薬学会第123年会  2003.3 

The alteration of clock genes expression as an adverse effect of drug. Invited

2003.3 

生体リズムを駆使した時間治療はどこまで進むか？ Invited

大戸茂弘

2003.3 

The manipulation of feeding schedule can modify the rhythmicity of drug response and pharmacokinetics. Invited International conference

Ohdo, S.

1st World Congress of Chronobiology.  2003.9 

Chronopharmacology of melatonin in mice to maximize the antitumor effect and minimize the rhythm disturbance effect. International conference

Akagi, T., Ushinohama, K., Higuchi, S., Ohdo, S.

1st world congress of chronobiology  2003.9 

Therapeutic index of irinotecan hydrochloride depends both upon the time of day and number of days between doses. International conference

To, H., Ohdo, S., Goto, N., Higuchi, S., Fujimura, A., Kobayashi, E.

1st world congress of chronobiology  2003.9 

Studies on optimizing dosing schedule of angiogenesis inhibitor. International conference

Nakagawa, H., Koyanagi, S., Kuramoto, Y., Soeda, S., Shimeno, H., Ohdo, S., Higuchi, S.

1st world congress of chronobiology  2003.9 

Molecular basis for circadian expression of vascular endothelial growth factors in tumor cells. International conference

Kuramoto, Y.,Koyanagi, S., Nakagawa, H., Ohdo, S., Higuchi, S., Aramaki, H., Soeda, S., Shimeno, H.

1st world congress of chronobiology.  2003.9 

The timing of antiangiogenic drugs. Invited International conference

Ohdo, S.

European Organisation for Research and Treatment of Cancer (EORTC): EORTC Chronotherapy Group 3rd Strategy Meeting.  2003.11 

Clock dysfunction induced by interferon. Invited International conference

Ohdo, S.

European Organisation for Research and Treatment of Cancer (EORTC): EORTC Chronotherapy Group 3rd Strategy Meeting.  2003.11 

Changes in effectiveness and toxicity with timing of drug administration. Invited International conference

Ohdo, S.

The 1st Asian Symposium for Pharmaceutical Sciences.  2004.1 

The alteration of clock genes expression as an adverse effect of drug. Invited International conference

Ohdo, S.

2nd International Symposium on Molecular Clock. Molecular Clock Tokyo 2004.  2004.2 

薬学と統計学. Invited

大戸茂弘.

日本薬学会第124年会  2004.3 

Studies on optimizing dosing schedule of angiogenesis inhibitor. International conference

Nakagawa, H., Koyanagi, S., Takiguchi, T., Kuramoto., Y., Ohdo, S., Higuchi, S.

Pharmaceutical sciences world congress (PSWC2004)  2004.5 

Influence of time-restricted feeding on dosing-time dependency of CPT-11-induced toxicity in mice. International conference

To, H., Goto, N., Tsuruda, K., Ohdo, S., Higuchi, S.

Pharmaceutical sciences world congress (PSWC2004)  2004.5 

The biological rhythm disturbance in HPA axis hyperactivated mice induced by dexamethasone. International conference

Ushijima, K., To, H., Ohdo, S., Higuchi, S.

Pharmaceutical sciences world congress (PSWC2004)  2004.5 

24-hr rhythmicity of CYP2E1 activity in liver and its possible mechanism. International conference

Matsunaga, N., To, H., Ohdo, S., Higuchi, S.

Pharmaceutical sciences world congress (PSWC2004)  2004.5 

Chronopharmacological approach for optimizing the dosing schedule of antiangiogenic agents. International conference

Kuramoto, Y., Koyanagi, S., Ohdo, S., Higuchi, S., Soeda, S., Shimeno, H.

Pharmaceutical sciences world congress (PSWC2004)  2004.5 

体内時計とリズム診断. Invited

濱田哲暢、瀧元美栄子、大村孝文、斉藤秀之、川谷淳子、上土井貴子、友田明美、三池輝久、中川博雄、寺薗英之、大戸茂弘、樋口駿、入江伸.

日本薬学会第125年会  2005.3 

生体リズムを考慮した創薬・医薬品適正使用. Invited

大戸茂弘.

日本薬学会第125年会  2005.3 

Palmitoyl lysophosphatidylcholine content in LDL correlate with serum platelet activating factor acetylhydrolase and diabetic microangiopathy. International conference

Iwase M, Sonoki K, Sasaki N, Ohdo S, Higuchi S, Hattori H, Iida M.

The 65 th scientific sessions of the american diabetes association  2005.6 

体内時計の分子機構を基盤にした時間薬物送達方法の開発. Invited

大戸茂弘.

第21回日本DDS学会  2005.7 

生体リズムを考慮した創薬・育薬・医薬品適正使用. Invited

大戸茂弘.

第13回クリニカルファーマシーシンポジウム  2005.7 

体内時計の分子機構を基盤にした薬の有効性と安全性の評価. Invited

大戸茂弘.

第26回In vitro発生毒性研究会  2005.9 

体内時計の分子機構を基盤にした時間薬物送達方法の開発. Invited

大戸茂弘.

第12回日本時間生物学会  2005.11 

薬学部の立場から. 特別パネルディスカッション「薬学における臨床薬理学教育　ー６年制導入を迎え」. Invited

大戸茂弘.

第26回日本臨床薬理学会  2005.12 

Chronopharmacological findings of antitumor drugs. Invited

2006.3 

Dosing time dependent variance of anti-immobility effect of fluvoxamine in forced swimming test. International conference

Ushijima, K., Sakaguchi, H., To, H., Ohdo, S., Higuchi, S.

Serotonin Club Meeting 2006, 6th IUPHAR satellite meeting.  2006.6 

制癌剤の時間薬理学的投与計画. Invited

大戸茂弘.

第14回クリニカルファーマシーシンポジウム  2006.7 

体内時計と時間薬理学. Invited

大戸茂弘.

三学会合同年会（第28回日本生物学的精神医学会、第36回日本神経精神薬理学会、第49回日本神経化学会大会）  2006.9 

ここまでわかった体内時計, 飲む時間によって クスリは効き方が異なる！Healthist 252, 16-19, 2018.

大戸茂弘

2018.11

慢性疼痛の概日変動メカニズムと新しい治療標的.医薬ジャーナル 54: 117-122, 2018.

楠瀬直樹, 小柳 悟, 松永直哉, 大戸茂弘

医薬ジャーナル 54: 117-122, 2018.   2018.10

大戸茂弘. 体内時計と薬の関係を利用した時間治療―現状と今後の展望―. 歯科薬物療法　37(1)、1-8、2018.4月

大戸 茂弘

歯科薬物療法　37(1)、1-8、2018.4月   2018.4

大戸茂弘、体内時計の分子機構を基盤にした時間薬物動態. 医学のあゆみ264(7), 579 -583, 2018.2月

大戸 茂弘

医学のあゆみ264(7), 579 -583, 2018.2月   2018.2

小柳 悟, 大戸 茂弘、薬物動態の概日リズムと種差 (特集 製剤設計における動物種差の問題)、Drug delivery system　32(5)、418-423、2017

小柳 悟, 大戸 茂弘

Drug delivery system　32(5)、418-423、2017   2017.11

大戸茂弘.　 時間医学. 　生体の科学 　67（6）,574-578, 2016. 12月

大戸 茂弘

生体の科学 　67（6）,574-578, 2016. 12月   2016.12

大戸茂弘.　 体内時計を基盤にした時間薬理学.　医薬品医療機器レギュラトリーサイエンス 　46（12）,837-845, 2015. 12月

大戸 茂弘

医薬品医療機器レギュラトリーサイエンス   2015.12

大戸茂弘.　 時間治療―現状と展望　―生体リズムを基盤にした治療―. 小児科臨床 　68（9）,　7-16, 2015. 9 月

大戸茂弘.

小児科臨床   2015.9

小柳 悟, 大戸茂弘；薬物動態の概日リズムとDDS開発. Drug Delivery System, 29(5): 439-446, 2014.

小柳悟

2014.11