Hot Article Award

2009.8   Analytical Sciences   Analysis of small amounts of D-amino acids and the study on their physiological functions in mammals

日本薬学会奨励賞

2006.3   日本薬学会   哺乳類内在性D-アミノ酸の高感度二次元分析と機能解析

日本分析化学会奨励賞

2003.9   日本分析化学会   哺乳類体内微量Ｄ−アミノ酸の選択的分析法開発

ポスター賞

2001.11   日本分析化学会   MALDI-TOF MSによる安定なPEG修飾コレステロール脱水素酵素本態の分析

AWARD Second Best Poster

2001.9   HPLC Kyoto (クロマトグラフィー科学会)   Alteration of the contents of D-amino acids in eight brain regions of rat after intravenous administration of five D-amino acids

九州分析化学奨励賞

1997.11   日本分析化学会九州支部   分離分析におけるカードランゲル電気泳動法及び生体内Ｄ−アミノ酸微量定量法の開発と応用

Determination of D- and L-Enantiomers of Threonine and allo-Threonine in Mammals using Two-Step High-Performance Liquid Chromatography Reviewed International journal

Hua ZHAO, Kenji HAMASE, Akiko MORIKAWA, Zongyin Qiu and Kiyoshi ZAITSU

Journal of Chromatography B   810 ( 2 )   245 - 250   2004.10

Crystal Structure of N-[(6-Methoxy-4-oxo-1,4-dihydroquinolin-3-yl)methyl]-2,2-dimethylpropanamide Reviewed International journal

Junzo HIRANO, Kenji HAMASE, Takeyuki AKITA and Kiyoshi ZAITSU

Analytical Sciences   2004.9

チアマゾールの透析膜における吸着性，医学と薬学 Reviewed

浜瀬健司，小柳多恵子，森川亜希子，井上朋美，財津　潔

医学と薬学   2003.11

2-Amino-3-phenylpyrazine, a Sensitive Fluorescence Prelabeling Reagent for the Chromatographic or Electrophoretic Determination of Saccharides Reviewed International journal

Koji YAMAMOTO, Kenji HAMASE and Kiyoshi ZAITSU

Journal of Chromatography A   1004 ( 1-2 )   99 - 106   2003.7

Determination of Endogenous Melatonin in the Individual Pineal Glands of Inbred Mice using Precolumn Oxidation Reversed-Phase Micro-High-Performance Liquid Chromatography Reviewed International journal

Tatsunosuke TOMITA, Kenji HAMASE, Hiromi HAYASHI, Hiroko FUKUDA, Junzo HIRANO and Kiyoshi ZAITSU

Analytical Biochemistry   316 ( 2 )   154 - 161   2003.5

Determination of D-Alanine in the Rat Central Nervous System and Periphery using Column-Switching High-Performance Liquid Chromatography Reviewed International journal

Akiko MORIKAWA, Kenji HAMASE and Kiyoshi ZAITSU

Analytical Biochemistry   312 ( 1 )   66 - 72   2003.1

Determination of Free D-Proline and D-Leucine in the Brains of Mutant Mice Lacking D-Amino-Acid Oxidase Activity Reviewed International journal

Kenji HAMASE, Tomomi INOUE, Akiko MORIKAWA, Ryuichi KONNO and Kiyoshi ZAITSU

Analytical Biochemistry   298 ( 2 )   253 - 258   2001.11

Determination of Minute Amounts of D-Leucine in Various Brain Regions of Rat and Mouse Using Column-Switching High-Performance Liquid Chromatography Reviewed International journal

Tomomi INOUE, Kenji HAMASE, Akiko MORIKAWA and Kiyoshi ZAITSU

Journal of Chromatography B   744 ( 1 )   213 - 219   2000.7

Determination of Pineal Melatonin by Precolumn Derivatization Reversed-Phase High Performance Liquid Chromatography and Its Application to the Study of Circadian Rhythm in Rats and Mice Reviewed International journal

Kenji HAMASE, Tatsunosuke TOMITA, Ayako KIYOMIZU and Kiyoshi ZAITSU

Analytical Biochemistry   279 ( 1 )   106 - 110   2000.1

メートル長高分離能光学分割カラムを用いる食酢中アラニンおよびセリン鏡像異性体の分析

石井千晴，古賀夢美，藤井　暁，秋田健行，三田真史，長野正信，浜瀬健司

BUNSEKI KAGAKU   73   337 - 344   2024.7

Development of a two-dimensional LC-MS/MS system for the determination of proline and 4-hydroxyproline enantiomers in biological and food samples

Chiharu ISHII, Yosuke TOJO, Komei IWASAKI, Akira FUJII, Takeyuki AKITA, Masanobu NAGANO, Masashi MITA, Tomomi IDE, Kenji HAMASE

Analytical Sciences   40   881 - 889   2024.5

Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu

Yoshinori TAKANO, Hiroshi NARAOKA, Jason P. DWORKIN, Toshiki KOGA, Kazunori SASAKI, Hajime SATO, Yasuhiro OBA, Nanako O. OGAWA, Toshihiro YOSHIMURA, Kenji HAMASE, Naohiko OHKOUCHI, Eric T. PARKER, José C. APONTE, Daniel P. GLAVIN, Yoshihiro FURUKAWA, Junken AOKI, Kuniyuki KANO, Shin-ichiro M. NOMURA, Francois-Regis ORTHOUS-DAUNAY, Philippe Schmitt-KOPPLIN, Hayabusa2-initial-analysis SOMteam*, Hisayoshi YURIMOTO, Tomoki NAKAMURA, Takaaki NOGUCHI, Ryuji OKAZAKI, Hikaru YABUTA, Kanako SAKAMOTO, Toru YADA, Masahiro NISHIMURA, Aiko NAKATO, Akiko MIYAZAKI, Kasumi YOGATA, Masanao ABE, Tatsuaki OKADA, Tomohiro USUI, Makoto YOSHIKAWA, Takanao SAIKI, Satoshi TANAKA, Fuyuto TERUI, Satoru NAKAZAWA, Sei-ichiro WATANABE, Yuichi TSUDA, Shogo TACHIBANA

Nature Communications   ( 15 )   5708   2024.5

Enantioselective three-dimensional high-performance liquid chromatographic determination of amino acids in the Hayabusa2 returned samples from the asteroid Ryugu

Aogu FURUSHO, Chiharu ISHII, Takeyuki AKITA, Mai OYAIDE, Masashi MITA, Hiroshi NARAOKA, Yoshinori TAKANO, Jason P. DWORKIN, Yasuhiro OBA, Toshiki KOGA, Kazuhiko FUKUSHIMA, Dan AOKI, Minako HASHIGUCHI, Hajime MITA, Yoshito CHIKARAISHI, Naohiko OHKOUCHI, Nanako O. OGAWA, Saburo SAKAI, Daniel P. GLAVIN, Jamie E. ELSILA, Eric T. PARKER, José C. APONTE, Hannah L. McLAIN, Francois-Regis ORTHOUS-DAUNAY, Véronique VUITTON, Roland THISSEN, Cédric WOLTERS, Philippe SCHMITT-KOPPLIN, Alexander RUF, Junko ISA, Norbert HERTKORN, John M. EILER, Toshihiro YOSHIMURA, Haruna SUGAHARA, Heather G. GRAHAM, Yoshihiro FURUKAWA, Daisuke ARAOKA, Satoru TANAKA, Takaaki YOSHIKAWA, Fumie KABASHIMA, Kazunori SASAKI, Hajime SATO, Tomoya YAMAZAKI, Morihiko ONOSE, Mayu MORITA, Yuki KIMURA, Kuniyuki KANO, Junken AOKI, Kosuke FUJISHIMA, Shin-ichiro NOMURA, Shogo TACHIBANA, Tomoki NAKAMURA, Takaaki NOGUCHI, Ryuji OKAZAKI, Hikaru YABUTA, Hisayoshi YURIMOTO, Kanako SAKAMOTO, Toru YADA, Masahiro NISHIMURA, Aiko NAKATO, Akiko MIYAZAKI, Kasumi YOGATA, Masanao ABE, Tomohiro USUI, Makoto YOSHIKAWA, Takanao SAIKI, Satoshi TANAKA, Fuyuto TERUI, Satoru NAKAZAWA, Tatsuaki OKADA, Sei-ichiro WATANABE, Yuichi TSUDA, Kenji HAMASE

Journal of Chromatography Open   ( 5 )   100134   2024.5

Evaluation of individual variation of D-amino acids in human plasma by a two-dimensional LC-MS/MS system and application to the early diagnosis of chronic kidney disease Reviewed International journal

@Chiharu ISHII, @Takeyuki AKITA, @Tomonori KIMURA, @Shinsuke SAKAI, @Masashi MITA, @Tomomi IDE, @Yoshitaka ISAKA, @Kenji HAMASE

Analytical Chemistry   96   4876 - 4883   2024.3

D‑Amino acids differentially trigger an inflammatory environment in vitro Reviewed International journal

@Siew Hwei YAP, @Cheng Siang LEE, @Nur Diyana ZULKIFI, @Darshinie SURESH, @Kenji HAMASE, @Kumitaa Theva DAS, @Reena RAJASURIAR, @Kok Hoong LEONG

Amino Acids   56   6   2024.2

D-Alanine affects the circadian clock to regulate glucose metabolism in the kidney Reviewed International journal

@Shinsuke SAKAI, @Youichi TANAKA, @Yusuke TSUKAMOTO, @Shihoko KIMURA-OHBA, @Atsushi HESAKA, @Kenji HAMASE, @Chin-Ling HSIEH, @Eiryo KAWAKAMI, @Hiraku ONO, @Kotaro YOKOTE, @Mitsuaki YOSHINO, @Daisuke OKUZAKI, @Hiroyo MATSUMURA, @Atsuko FUKUSHIMA, @Masashi MITA, @Maiko NAKANE, @Masao DOI, @Yoshitaka ISAKA, @Tomonori KIMURA

Kidney360   5   237 - 251   2024.2

Development of a three-dimensional HPLC system for the determination of serine, threonine and allo-threonine enantiomers in the plasma of patients with chronic kidney disease Reviewed International journal

#Mai OYAIDE, @Chiharu ISHII, @Takeyuki AKITA, @Tomonori KIMURA, @Shinsuke SAKAI, @Masayuki MIZUI, @Masashi MITA, @Tomomi IDE, @Yoshitaka ISAKA, @Kenji HAMASE

Journal of Chromatography A   1719   464739   2024.2

Polycyclic aromatic hydrocarbons in samples of Ryugu formed in the interstellar medium Reviewed International journal

@Sarah S. ZEICHNER, @José C. APONTE, @Surjyendu BHATTACHARJEE, @Guannan DONG, @Amy E. HOFMANN, @Jason P. DWORKIN, @Daniel P. GLAVIN, @Jamie E. ELSILA, @Heather V. GRAHAM, @Hiroshi NARAOKA, @Yoshinori TAKANO, @Shogo TACHIBANA, @Allison T. KARP, @Kliti GRICE, @Alex I. HOLMAN, @Katherine H. FREEMAN, @Hisayoshi YURIMOTO, @Tomoki NAKAMURA, @Takaaki NOGUCHI, @Ryuji OKAZAKI, @Hikaru YABUTA, @Kanako SAKAMOTO, @Toru YADA, @Masahiro NISHIMURA, @Aiko NAKATO, @Akiko MIYAZAKI, @Kasumi YOGATA, @Masanao ABE, @Tatsuaki OKADA, @Tomohiro USUI, @Makoto YOSHIKAWA, @Takanao SAIKI, @Satoshi TANAKA, @Fuyuto TERUI, @Satoru NAKAZAWA, @Sei-ichiro WATANABE, @Yuichi TSUDA, @Kenji HAMASE, @Kazuhiko FUKUSHIMA, @Dan AOKI, @Minako HASHIGUCHI, @Hajime MITA, @Yoshito CHIKARAISHI, @Naohiko OHKOUCHI, @Nanako O. OGAWA, @Saburo SAKAI, @Eric T. PARKER, @Hannah L. McLAIN, @Francois-Regis ORTHOUS-DAUNAY, @Véronique VUITTON, @Cédric WOLTERS, @Philippe SCHMITT-KOPPLIN, @Norbert HERTKORN, @Roland THISSEN, @Alexander RUF, @Junko ISA, @Yasuhiro OBA, @Toshiki KOGA, @Toshihiro YOSHIMURA, @Daisuke ARAOKA, @Haruna SUGAHARA, @Aogu FURUSHO, @Yoshihiro FURUKAWA, @Junken AOKI, @Kuniyuki KANO, @Shin-ichiro M. NOMURA, @Kazunori SASAKI, @Hajime SATO, @Takaaki YOSHIKAWA, @Satoru TANAKA, @Mayu MORITA, @Morihiko ONOSE, @Fumie KABASHIMA, @Kosuke FUJISHIMA, @Tomoya YAMAZAKI, @Yuki KIMURA, @John M. EILER

Science   382   1411 - 1416   2023.12

Enantioselective analysis of lactate, hydroxybutyrates and malate in human physiological fluids using a three-dimensional HPLC system Reviewed International journal

#Hsin-Miao TSAI, @Chin-Ling HSIEH, @Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

Chromatography   44   105 - 113   2023.9

Development of an enantioselective three-dimensional HPLC system for the determination of alanine, valine, isoleucine, allo-isoleucine and leucine in human plasma and urine Reviewed International journal

#Yuri NAGATA, @Takeyuki AKITA, @Chiharu ISHII, #Mai OYAIDE, @Masashi MITA, @Tomomi IDE,@Kenji HAMASE

Journal of Pharmaceutical and Biomedical Analysis Open   2   100013   2023.6

The spatial distribution of soluble organic matter and their relationship to minerals in the asteroid (162173) Ryugu Reviewed International journal

@Minako HASHIGUCHI, @Dan AOKI, @Kazuhiko FUKUSHIMA, @Hiroshi NARAOKA, @Yoshinori TAKANO, @Jason P. DWORKIN, @Karin E. DWORKIN, @José C. APONTE, @Jamie E. ELSILA, @John M. EILER, @Yoshihiro FURUKAWA, @Aogu FURUSHO, @Daniel P. GLAVIN, @Heather V. GRAHAM, @Kenji HAMASE, @Norbert HERTKORN, @Junko ISA, @Toshiki KOGA, @Hannah L. McLAIN, @Hajime MITA, @Yasuhiro OBA, @Nanako O. OGAWA, @Naohiko OHKOUCHI, @Francois‑Regis ORTHOUS ‑DAUNAY, @Eric T. PARKER, @Alexander RUF, @Saburo SAKAI, @Philippe SCHMITT-KOPPLIN, @Haruna SUGAHARA, @Roland THISSEN, @Véronique VUITTON, @Cédric WOLTERS, @Toshihiro YOSHIMURA, @Hisayoshi YURIMOTO, @Tomoki NAKAMURA, @Takaaki NOGUCHI, @Ryuji OKAZAKI, @Hikaru YABUTA, @Kanako SAKAMOTO,@ Shogo TACHIBANA, @Toru YADA, @Masahiro NISHIMURA, @Aiko NAKATO, @Akiko MIYAZAKI, @Kasumi YOGATA, @Masanao ABE, @Tomohiro USUI, @Makoto YOSHIKAWA, @Takanao SAIKI, @Satoshi TANAKA, @Fuyuto TERU, @Satoru NAKAZAWA, @Sei‑ichiro WATANABE, @Yuichi TSUDA

Earth, Planets and Space   75   73   2023.5

Design of novel mixed-mode columns for analysis of amino acids derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole and the evaluation of retention properties Reviewed International journal

#Yuri NAGATA, @Takeyuki AKITA, @Aogu FURUSHO, @Chiharu ISHII, @Masashi MITA, @Kenji HAMASE

Chromatography   44   83 - 87   2023.4

A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Reviewed International journal

Pattama WIRIYASERMKUL, Satomi MORIYAMA, Masataka SUZUKI, Pornparn KONGPRACHA, Nodoka NAKAMAE, Saki TAKESHITA, Yoko TANAKA, Akina MATSUDA, Masaki MIYASAKA, Kenji HAMASE, Tomonori KIMURA, Masashi MITA, Jumpei SASABE, Shushi NAGAMOR

eLife   12   RP92615   2023.4

Mammals sustain amino acid homochirality against chiral conversion by symbiotic microbes Reviewed International journal

@Yusuke GONDA, @Akina MATSUDA, @Kenichiro ADACHI, @Chiharu ISHII, @Masataka SUZUKI, @Akina OSAKI, @Masashi MITA, @Naoto NISHIZAKI, @Yoshiyuki OHTOMO, @Toshiaki SHIMIZU, @Masato YASUI, @Kenji HAMASE, @Jumpei SASABE

Proceedings of the National Academy of Sciences of the United States of America   120   e2300817120   2023.3

Chiral amino acid analysis in the plasma of B6DAO-/- mice lacking D-amino acid oxidase activity Reviewed International journal

@Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Ryuichi KONNO, @Kenji HAMASE

Chromatography   44   39 - 43   2023.2

Soluble organic molecules in samples of the carbonaceous asteroid (162173) Ryugu Reviewed International journal

@Hiroshi NARAOKA, @Yoshinori TAKANO, @Jason P. DWORKIN, @Yasuhiro OBA, @Kenji HAMASE, @Aogu FURUSHO, @Nanako O. OGAWA, @Minako HASHIGUCHI, @Kazuhiko FUKUSHIMA, @Dan AOKI, @Philippe Schmitt-KOPPLIN, @José C. APONTE, @Eric T. PARKER, @Daniel P. GLAVIN, @Hannah L. McLAIN, @Jamie E. ELSILA, @Heather V. GRAHAM, @John M. EILER, @Francois-Regis Orthous-DAUNAY, @Cédric WOLTERS, @Junko ISA, @Véronique VUITTON, @Roland THISSEN, @Saburo SAKAI, @Toshihiro YOSHIMURA, @Toshiki KOGA, @Naohiko OHKOUCHI, @Yoshito CHIKARAISHI, @Haruna SUGAHARA, @Hajime MITA, @Yoshihiro FURUKAWA, @Norbert HERTKORN, @Alexander RUF, @Hisayoshi YURIMOTO, @Tomoki NAKAMURA, @Takaaki NOGUCHI, @Ryuji OKAZAKI, @Hikaru YABUTA, @Kanako SAKAMOTO, @Shogo TACHIBANA, @Harold C. CONNOLLY, Jr., @Dante S. LAURETTA, @Masanao ABE, @Toru YADA, @Masahiro NISHIMURA, @Kasumi YOGATA, @Aiko NAKATO, @Miwa YOSHITAKE, @Ayako SUZUKI, @Akiko MIYAZAKI, @Shizuho FURUYA, @Kentaro HATAKEDA, @Hiromichi SOEJIMA, @Yuya HITOMI, @Kazuya KUMAGAI, @Tomohiro USUI, @Tasuku HAYASHI, @Daiki YAMAMOTO, @Ryota FUKAI, @Kohei KITAZATO, @Seiji SUGITA, @Noriyuki NAMIKI, @Masahiko ARAKAWA, @Hitoshi IKEDA, @Masateru ISHIGURO, @Naru HIRATA, @Koji WADA, @Yoshiaki ISHIHARA, @Rina NOGUCHI, @Tomokatsu MOROTA, @Naoya SAKATANI, @Koji MATSUMOTO, @Hiroki SENSHU, @Rie HONDA, @Eri TATSUMI, @Yasuhiro YOKOTA, @Chikatoshi HONDA, @Tatsuhiro MICHIKAMI, @Moe MATSUOKA, @Akira MIURA, @Hirotomo NODA, @Tetsuya YAMADA, @Keisuke YOSHIHARA, @Kosuke KAWAHARA, @Masanobu OZAKI, @Yu-ichi IIJIMA, @Hajime YANO, @Masahiko HAYAKAWA, @Takahiro IWATA, @Ryudo TSUKIZAKI, @Hirotaka SAWADA, @Satoshi HOSODA, @Kazunori OGAWA, @Chisato OKAMOTO, @Naoyuki HIRATA, @Kei SHIRAI, @Yuri SHIMAKI, @Manabu YAMADA, @Tatsuaki OKADA, @Yukio YAMAMOTO, @Hiroshi TAKEUCHI, @Atsushi FUJII, @Yuto TAKEI, @Kento YOSHIKAWA, @Yuya MIMASU, @Go ONO, @Naoko OGAWA, @Shota KIKUCHI, @Satoru NAKAZAWA, @Fuyuto TERUI, @Satoshi TANAKA, @Takanao SAIKI, @Makoto YOSHIKAWA, @Sei-ichiro WATANABE, @Yuichi TSUDA

Science,   379   eabn9033   2023.2

Development of a three-dimensional HPLC system for acidic amino acid enantiomers and determination of their amounts in mice lacking D-aspartic acid oxidase activity Reviewed International journal

@Chiharu ISHII, #Rin MORINAGA, #Miho TAKAHASHI, @Masashi MITA, @Takeyuki AKITA, @Kenji HAMASE

Journal of Pharmaceutical and Biomedical Analysis Open   1   100004   2023.1

Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus Reviewed International journal

@Yusuke NAKADE, @Yasunori IWATA, @Norihiko SAKAI, @Masashi MITA, @Maiko NAKANE, @Kenji HAMASE, @Wataru SUDA, @Tadashi TOYAMA, @Shinji KITAJIMA, @Akinori HARA, @Miho SHIMIZU, @Chikako OGUSHI, @Kengo FURUICHI, @Yoshitaka KOSHINO, @Hidetoshi MORITA, @Masahira HATTORI, @Takashi WADA

Scientific Reports   12   21773   2022.12

Endogenous D-serine exists in the mammalian brain independent of synthesis by serine racemase Reviewed International journal

@Akina OSAKI, @Marie AOYAMA, @Masashi MITA, @Kenji HAMASE, @Masato YASUI, @Jumpei SASABE

Biochemical and Biophysical Research Communications   641   186 - 191   2022.12

Two-dimensional chiral HPLC analysis of lactate, hydroxybutyrates and malate in human plasma Reviewed

#Hsin-Miao TSAI, @Chin-Ling HSIEH, @Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE @Kenji HAMASE

Chromatography   43   119 - 126   2022.10

Ultrafast simultaneous chiral analysis of native amino acid enantiomers using supercritical fluid chromatography/tandem mass spectrometry Reviewed International journal

@Yutaka KONYA, @Yoshihiro IZUMI, @Kenji HAMASE, @Takeshi BAMBA

Journal of Chromatography A   1677   463305   2022.7

Simultaneous determination of seven β2-agonists in livestock products using an LC-MS/MS system Reviewed

@Takako HAYASHI, @Kenji HAMASE

Chromatography   43   101 - 109   2022.7

Astrocytic D-amino acid oxidase degrades D-serine in the hindbrain Reviewed International journal

@Yusuke GONDA, @Chiharu ISHII, @Masashi MITA, @Naoto NISHIZAKI, @Yoshiyuki OHTOMO, @Kenji HAMASE, @Toshiaki SHIMIZU, @Jumpei SASABE

FEBS Letters   596   2889 - 2897   2022.6

Off-line two-dimensional LC-MS/MS determination of tryptophan enantiomers in mammalian urine and alteration of their amounts in D-amino acid oxidase deficient mice Reviewed International journal

@Chiharu ISHII, #Noburo TAKIZAWA, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Ryuichi KONNO, @Kenji HAMASE

Journal of Pharmaceutical and Biomedical Analysis   219   114919   2022.6

Enantioselective determination of hydroxy amino acids in Japanese traditional amber rice vinegars Reviewed International journal

#Mai OYAIDE, @Chiharu ISHII, @Akira FUJII, @Takeyuki AKITA, @Masashi MITA, @Masanobu NAGANO, @Kenji HAMASE

Chromatography   43   59 - 65   2022.5

Development of an off-line heart cutting two-dimensional HPLC system for enantioselective analysis of serine, threonine and allo-threonine in human physiological fluids Reviewed International journal

#Mai OYAIDE, #Aogu FURUSHO, @Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Kenji HAMASE

Journal of Pharmaceutical and Biomedical Analysis   217   2022.4

Protective effect of D-alanine against acute kidney injury Reviewed International journal

@Yasunori IWATA, @Yusuke NAKADE, @Shinji KITAJIMA, @Shiori YONEDA-NAKAGAWA, @Megumi OSHIMA, @Norihiko SAKAI, @Hisayuki OGURA, @Koichi SATO, @Tadashi TOYAMA, @Yuta YAMAMURA, @Taro MIYAGAWA, @Hiroka YAMAZAKI, @Akinori HARA, @Miho SHIMIZU, @Kengo FURUICHI, @Masashi MITA, @Kenji HAMASE, @Tomohiro TANAKA, @Motohiro NISHIDA, @Wataru MURAMATSU, @Hisashi YAMAMOTO, @Shigeyuki SHICHINO, @Satoshi UEHA, @Kouji MATSUSHIMA, @Takashi WADA

American Journal of Physiology, Renal Physiology   322   F667 - F679   2022.4

Chiral resolution of plasma amino acids reveals enantiomer-selective associations with organ functions Reviewed International journal

@Masataka SUZUKI, @Ryoko SHIMIZU-HIROTA, @Masashi MITA, @Kenji HAMASE, @Jumpei SASABE

Amino Acids   54   421 - 432   2022.2

Plasma D-amino acids are associated with markers of immune activation and organ dysfunction in people with HIV Reviewed International journal

@Siew Hwei YAP, @Cheng Siang LEE, #Aogu FURUSHO, @Chiharu ISHII, @Syahirah SHAHARUDIN, @Nurul Syuhada ZULHAIMI, @Adeeba KAMARULZAMAN, @Shahrul Bahyah KAMARUZZAMAN, @Masashi MITA, @Kok Hoong LEONG, @Kenji HAMASE, @Reena RAJASURIAR

AIDS   36   911 - 921   2022.1

Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions Reviewed International journal

@Chinatsu SHINOZAKI, @Keita KOHNO, @Mitsunori SHIROISHI, @Daisuke TAKAHASHI, @Yu YOSHIKAWA, @Yoshito ABE, @Kenji HAMASE, @Makoto NAKAKIDO, @Kohei TSUMOTO,@Kazuhide INOUE, @Makoto TSUDA, @Tadashi UEDA

Scientific Reports   12   131   2022.1

Two-dimensional high-performance liquid chromatographic determination of chiral amino acids in food samples and human physiological fluids using fluorescence derivatization with 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole Reviewed International journal

#Aogu FURUSHO, @Karina Akemy IKEJIRI, @Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Masanobu NAGANO, @Tomomi IDE, @Kenji HAMASE

Chromatography   43   29 - 35   2022.1

Chiral analysis of lactate in various food samples including Japanese traditional amber rice vinegar and the developmental changes during fermentation processes Reviewed International journal

#Chin-Ling HSIEH, @Chiharu ISHII, @Takeyuki AKITA, @Akira FUJII, @Kazunori HASHIGUCHI, @Masanobu NAGANO, @Masashi MITA, @Jen-Ai LEE, @Kenji HAMASE

Chromatography   42   151 - 158   2021.10

Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease Reviewed International journal

@Yasutaka NAKASHIMA, @Yasunari SAKAI, @Yumi MIZUNO, @Kenji FURUNO, @Keiichi HIRONO, @Shinichi TAKATSUKI, @Hiroyuki SUZUKI,@Yoshihiro ONOUCHI, @Tohru KOBAYASHI, @Kazuhiro TANABE, @Kenji HAMASE, @Tomofumi MIYAMOTO, @Ryohei AOYAGI, @Makoto ARITA, @Kenichiro YAMAMURA, @Tamami TANAKA, @Hisanori NISHIO, @Hidetoshi TAKADA, @Shouichi OHGA, @Toshiro HARA

Cardiovascular Research   117 ( 1 )   96 - 108   2021.1

Determination of phenylalanine enantiomers in the plasma and urine of mammals and D-amino acid oxidase deficient rodents using two-dimensional high-performance liquid chromatography Reviewed International journal

@Sui-Wen HSIAO, #Chiharu ISHII, #Aogu FURUSHO, #Chin-Ling HSIEH, @Yukiko SHIMIZU, @Takeyuki AKITA, @Masashi MITA, @Tadashi OKAMURA, @Ryuichi KONNO, @Tomomi IDE, @Ching-Kuo LEE, @Kenji HAMASE

Biochimica et Biophysica Acta - Proteins and Proteomics   1869   2021.1

Host-microbe cross-talk governs amino acid chirality to regulate survival and differentiation of B cells Reviewed International journal

@Masataka SUZUKI, @Tomohisa SUJINO, @Sayako CHIBA, @Yosuke HARADA, @Motohito GOTO, @Riichi TAKAHASHI, @Masashi MITA, @Kenji HAMASE, @Takanori KANAI, @Mamoru ITO, @Matthew K.WALDOR, @Masato YASUI, @Jumpei SASABE

Science Advances   7   2021.1

Determination of clenbuterol in various edible parts of livestock products by LC-MS/MS and LC-MS/MS/MS methods Reviewed International journal

#Takako HAYASHI, @Kenji HAMASE

Chromatography   42   43 - 48   2021.1

Development of a selective three-dimensional HPLC system for enantiomer discriminated analysis of lactate and 3-hydroxybutyrate in human plasma and urine Reviewed International journal

#Chin-Ling HSIEH, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

Journal of Pharmaceutical and Biomedical Analysis   195   2020.12

Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity Reviewed International journal

@Yuta KOHRO, @Tsuyoshi MATSUDA, #Kohei YOSHIHARA, #Keita KOHNO, @Keisuke KOGA, @Ryuichi KATSURAGI, @Takaaki OKA, @Ryoichi TASHIMA, @Sho MUNETA, @Takuya YAMANE, @Shota OKADA, #Kazuya MOMOKINO, #Aogu FURUSHO, @Kenji HAMASE, @Takumi OTI,@ Hirotaka SAKAMOTO, @Kenichiro HAYASHIDA, @Ryosuke KOBAYASHI, @Takuro HORII, @Izuho HATADA, @Hidetoshi TOZAKI-SAITOH, @Katsuhiko MIKOSHIBA, @Verdon TAYLOR, @Kazuhide INOUE, @Makoto TSUDA

Nature Neuroscience   23 ( 11 )   1376 - 1387   2020.10

High-performance liquid chromatographic determination of chiral amino acids using pre-column derivatization with o-phthalaldehyde and N-tert-butyloxycarbonyl-D-cysteine and application to vinegar samples Reviewed International journal

#Aogu FURUSHO, @Mintranee OBROMSUK, @Takeyuki AKITA, @Masashi MITA, @Masanobu NAGANO, @Pornchai ROJSITTHISAK, @Kenji HAMASE

Chromatography   41   147 - 151   2020.9

Three-dimensional high-performance liquid chromatographic analysis of chiral amino acids in carbonaceous chondrites Reviewed International journal

#Aogu FURUSHO, @Takeyuki AKITA, @Masashi MITA, @Hiroshi NARAOKA, @Kenji HAMASE

Journal of Chromatography A   1625   2020.8

Chemiluminescence of methoxycarbonylphenyl 10-methyl-10λ4-2,7-disubstituted acridine-9-carboxylate derivatives Reviewed International journal

@Manabu NAKAZONO, @Shinkoh NANBU, @Takeyuki AKITA, @Kenji HAMASE

Journal of Photochemistry & Photobiology, A: Chemistry   403   112851   2020.8

A colorimetric assay method for measuring D-glutamate cyclase activity Reviewed International journal

@Masumi KATANE, @Risa MOTODA, @Makoto ARIYOSHI, @Shuhei TATEISHI, @Kazuki NAKAYAMA, @Yasuaki SAITOH, @Tetsuya MIYAMOTO, @Masae SEKINE, @Masashi MITA, @Kenji HAMASE, @Satoaki MATOBA, @Kumiko SAKAI-KATO, @Hiroshi HOMMA

Analytical Biochemistry   605   113838   2020.7

D-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats Reviewed International journal

@Yukiko SHIMIZU, #Chiharu ISHII, @Reiko YANOBU-TAKANASHI, @Kenta NAKANO, @Akio IMAIKE, @Masashi MITA, @Kenji HAMASE,@Tadashi OKAMURA

Biochimica et Biophysica Acta - Proteins and Proteomics   1868 ( 9 )   140463   2020.6

Determination of temporal changes in serum and urinary lactate and 3-hydroxybutyrate enantiomers in mice with nephrotoxic serum nephritis by multi-dimensional HPLC Reviewed International journal

@Po-Yeh LIN, @Shih-Ming CHEN, #Chin-Ling HSIEH, @Chia-Yu LIN, @Yu-Shen HUANG, @Kenji HAMASE, @Jen-Ai LEE

Journal of Pharmaceutical and Biomedical Analysis   188   113367   2020.5

Analysis of total thiols in the urine of a cystathionine β-synthase-deficient mouse model of homocystinuria using hydrophilic interaction chromatography Reviewed International journal

@Chun-Fang CHANG, @Kenji HAMASE, @Makoto TSUNODA

Molecules   ( 25 )   1735   2020.4

Serum D-serine accumulation after proximal renal tubular damage involves, neutral amino acid transporter Asc-1 Reviewed International journal

@Masataka SUZUKI, @Yusuke GONDA, @Marina YAMADA, @Arno A. VANDEBROEK,@Masashi MITA, @Kenji HAMASE, @Masato YASUI, @Jumpei SASABE

Scientific Reports   ( 9 )   16705   2019.11

Three-dimensional high-performance liquid chromatographic determination of Asn, Ser, Ala, and Pro enantiomers in the plasma of patients with chronic kidney disease Reviewed International journal

#Aogu FURUSHO, @Reiko KOGA, @Takeyuki AKITA, @Masashi MITA, @Tomonori KIMURA, @Kenji HAMASE

Analytical Chemistry   ( 91 )   11569 - 11575   2019.9

Dynamics of D-serine reflected the recovery course of a patient with rapidly progressive glomerulonephritis Reviewed International journal

@Atsushi HESAKA, @Keiko YASUDA, @Shinsuke SAKAI, @Hiroaki YONISHI, @Tomoko NAMBA-HAMANO, @Atsushi TAKAHASHI, @Masayuki MIZUI, @Kenji HAMASE, @Rakan MATSUI, @Masashi MITA, @Masaru HORIO, @Yoshitaka ISAKA, @Tomonori KIMURA

CEN Case Reports   8   297 - 300   2019.7

New applications of high-resolution analytical methods to study trace organic compounds in extraterrestrial materials Reviewed International journal

@Hiroshi NARAOKA, @Minako HASHIGUCHI, @Yu SATO, @Kenji HAMASE

Life   62 ( 9 )   9030062   2019.7

Synthesis, chemiluminescence, and application of 2,4-disubstituted phenyl 10-methyl-10λ4-acridine-9-carboxylates Reviewed International journal

@Manabu NAKAZONO, @Shinkoh NANBU, @Takeyuki AKITA, @Kenji HAMASE

Dyes and Pigments   ( 170 )   107628   2019.6

Determination of chiral amino acids in various fermented products using a two-dimensional HPLC-MS/MS system Reviewed International journal

#Chiharu ISHII, @Takeyuki AKITA, @Masanobu NAGANO, @Masashi MITA, @Kenji HAMASE

Chromatography   ( 40 )   83 - 87   2019.5

Development of a three-dimensional HPLC system for the simultaneous determination of lactate and 3-hydroxybutyrate enantiomers in mammalian urine Reviewed International journal

#Chin-Ling HSIEH, @Po-Yeh LIN, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

CHROMATOGRAPHY   ( 40 )   25 - 32   2019.2

D-Serine reflects kidney function and diseases Reviewed International journal

@Atsushi HESAKA, @Shinsuke SAKAI, @Kenji HAMASE, @Tatsuhiko IKEDA, @Rakan MATSUI, @Masashi MITA, @Masaru HORIO, @Yoshitaka ISAKA, @Tomonori KIMURA

Scientific Reports   ( 9 )   5104   2019.1

A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats Reviewed International journal

@Yukiko SHIMIZU, @Rieko YANOBU-TAKANASHI, @Kenta NAKANO, @Kenji HAMASE, @Toshiaki SHIMIZU, @Tadashi OKAMURA

Mammalian Genome   ( 30 )   23 - 33   2018.12

Gut microbiota-derived D-serine protects from acute kidney injury Reviewed International journal

@Yusuke NAKADE, @Yasunori IWATA, @Kengo FURUICHI, @Masashi MITA, @Kenji HAMASE, @Ryuichi KONNO, @Taito MIYAKE, @Norihiko SAKAI, @Shinji KITAJIMA, @Tadashi TOYAMA, @Yasuyuki SHINOZAKI, @Akihiro SAGARA, @Taro MIYAGAWA, @Akinori HARA, @Miho SHIMIZU, @Yasutaka KAMIKAWA, @Kouichi SATO, @Megumi OSHIMA, @Shiori YONEDA-NAKAGAWA, @Yuta Yamamura, @Shuichi KANEKO, @Tetsuya MIYAMOTO, @Masumi KATANE, @Hiroshi HOMMA, @Hidetoshi MORITA, @Wataru SUDA, @Masahira HATTORI, @Takashi WADA

JCI Insight   ( 3 )   e97957   2018.10

Determination of trace amounts of chiral amino acids in complicated biological samples using two-dimensional high-performance liquid chromatography with an innovative “Shape-Fitting” peak identification/quantification method Reviewed International journal

@Kenji HAMASE,@Tatsuhiko IKEDA, #Chiharu ISHII, @Shoto ISHIGO, @Kei MASUYAMA, @Takeyuki AKITA, #Aogu FURUSHO, #Miho TAKAHASHI, @Tomomi IDE, @Masashi MITA

Chromatography   ( 39 )   147 - 152   2018.10

Structural and enzymatic properties of mammalian D-glutamate cyclase Reviewed International journal

@Masumi KATANE, @Makoto ARIYOSHI, @Shuhei TATEISHI, @Sachi KOIWAI, @Kaoruko TAKAKU, @Kenichiro NAGAI, @Kazuki NAKAYAMA, @Yasuaki SAITOH, @Tetsuya MIYAMOTO, @Masae SEKINE, @Masashi MITA, @Kenji HAMASE, @Satoaki MATOBA, @Hiroshi HOMMA

Archives of Biochemistry and Biophysics   ( 654 )   10 - 18   2018.9

Development of an online two-dimensional high-performance liquid chromatographic system in combination with tandem mass spectrometric detection for enantiomeric analysis of free amino acids in human physiological fluid Reviewed International journal

#Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Kenji HAMASE

Journal of Chromatography A   ( 1570 )   91 - 98   2018.7

Development of a highly-sensitive two-dimensional HPLC system with narrowbore reversed-phase and microbore enantioselective columns and application to the chiral amino acid analysis of the mammalian brain Reviewed International journal

#Aogu FURUSHO,@Reiko KOGA,@Takeyuki AKITA,@Yurika MIYOSHI,@Masashi MITA,@Kenji HAMASE

Chromatography   ( 39 )   83 - 90   2018.4

Multi-dimensional HPLC analysis of serine containing chiral dipeptides in Japanese traditional amber rice vinegar Reviewed International journal

#Nutchaya SEREEKITTIKUL, @Reiko KOGA, @Takeyuki AKITA,#Aogu FURUSHO,@Roland REISCHL,@Masashi MITA, @Akira FUJII,@Kazunori HASHIGUCHI, @Masanobu NAGANO, @Wolfgang LINDNER, @Kenji HAMASE

Chromatography   ( 39 )   59 - 66   2018.3

Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human plasma and urine using a narrowbore online two-dimensional HPLC system Reviewed International journal

#Chin-Ling HSIEH, @Reiko KOGA, #Aogu FURUSHO, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

Journal of Separation Science,   ( 41 )   1298 - 1306   2018.1

Two-dimensional HPLC-MS/MS determination of multiple D-amino acid residues in the proteins stored under various pH conditions Reviewed International journal

Chiharu ISHII, Tetsuya MIYAMOTO, Shoto ISHIGO, Yurika MIYOSHI, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE

Chromatography   38   65 - 72   2017.5

D-Glutamate is metabolized in the heart mitochondria Reviewed International journal

Makoto ARIYOSHI, Masumi KATANE, Kenji HAMASE, Yurika MIYOSHI, Maiko NAKANE, Atsushi HOSHINO, Yoshifumi OKAWA, Yuichiro MITA, Satoshi KAIMOTO, Motoki UCHIHASHI, Kuniyoshi FUKAI, Kazunori ONO, Syuhei TATEISHI, Daichi HATO, Ryoetsu YAMANAKA, Sakiko HONDA, Yohei FUSHIMURA, Eri IWAI-KANAI, Naotada ISHIHARA

Scientific Reports   7   43911   2017.3

Sleep-awake profile related circadian D-alanine rhythm in human serum and urine Reviewed International journal

Akiko MORIKAWA, Hideoki FUKUOKA, Keiko UEZONO, Masashi MITA, Satoru KOYANAGI, shigehiro OHDO, Kiyoshi ZAITSU, Kenji HAMASE

Chromatography   38   53 - 58   2017.3

Quantification of biological thiols in the plasma of a homocystinuria model with cystathionine β-synthase deficiency utilizing hydrophilic interaction liquid chromatography and fluorescence detection Reviewed International journal

Muneki ISOKAWA, Kentaro KOBAYASHI, Yurika MIYOSHI, Masashi MITA, Takashi FUNATSU, Kenji HAMASE, Makoto TSUNODA

Chromatography   37   147 - 151   2016.9

Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota Reviewed International journal

Jumpei Sasabe, Yurika Miyoshi, Seth Rakoff-NAHOUM, Ting ZHANG, Masashi MITA, Brigid M. DAVIS, Kenji HAMASE, Matthew K. WALDOR

Nature Microbiology   1   16125   2016.7

Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system Reviewed International journal

Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE

Journal of Chromatography A   ( 1467 )   312 - 317   2016.7

Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease Reviewed International journal

Tomonori KIMURA, Kenji HAMASE, Yurika MIYOSHI, Ryohei YAMAMOTO, Keiko YASUDA, Masashi MITA, Hiromi RAKUGI, Terumasa HAYASHI, Yoshitaka ISAKA

Scientific Reports   ( 6 )   2016.5

Enantioselective determination of phenylalanine, tyrosine and 3,4-dihydroxyphenylalanine in the urine of D-amino acid oxidase deficient mice using two-dimensional high-performance liquid chromatography Reviewed International journal

Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE

Chromatography   37 ( 1 )   15 - 22   2016.1

Participation of D-serine in the development and reproduction of the silkworm Bombyx mori Reviewed International journal

Minoru TANIGAWA, Chihiro SUZUKI, Kimio NIWANO, Rensuke KANEKATSU, Hiroyuki TANAKA, Kihachiro HORIIKE, Kenji HAMASE, Yoko NAGATA

Journal of Insect Physiology   ( 87 )   20 - 29   2016.1

Development of a fully-automated on-line oxidation column-switching HPLC system for the determination of endogenous melatonin in human clinical samples Reviewed International journal

Tsubasa OYAMA, Rie NAGAI, Mayumi FUJIMOTO, Ryoko KONISHI, Masashi MITA, Keiko UEZONO, Kiyoshi ZAITSU, Kenji HAMASE

Analytical Sciences   31 ( 11 )   1129 - 1135   2015.11

Establishment of a two-dimensional chiral HPLC system for the simultaneous detection of lactate and 3-hydroxybutyrate enantiomers in human clinical samples Reviewed International journal

Shu-Ling LIU, Tsubasa OYAMA, Yurika MIYOSHI, Shiow-Yunn SHEU, Masashi MITA, Tomomi IDE, Wolfgang LINDNER, Kenji HAMASE, Jen-Ai LEE

Journal of Pharmaceutical and Biomedical Analysis   ( 116 )   80 - 85   2015.6

Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis Reviewed International journal

Tsubasa OYAMA, Eiichi NEGISHI, Hirohisa ONIGAHARA, Nao KUSANO, Yurika MIYOSHI, Masashi MITA, Manabu NAKAZONO, Sumio OHTSUKI, Akio OJIDA, Wolfgang LINDNER, Kenji HAMASE

Journal of Pharmaceutical and Biomedical Analysis   ( 116 )   71 - 79   2015.6

Establishment of a two-dimensional HPLC-MS/MS method combined with DCl/D2O hydrolysis for the determination of trace amounts of D-amino acid residues in proteins Reviewed International journal

Shoto ISHIGO, Eiichi NEGISHI, Yurika MIYOSHI, Hirohisa ONIGAHARA, Masashi MITA, Tetsuya MIYAMOTO, Haruhiko MASAKI, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE

Chromatography   36   45 - 50   2015.5

Simultaneous analysis of D-alanine, D-aspartic acid, and D-serine using chiral high-performance liquid chromatography-tandem mass spectrometry and its application to the rat plasma and tissues Reviewed International journal

Sachise KARAKAWA, Kazutaka SHIMBO, Naoyuki YAMADA, Toshimi MIZUKOSHI, Hiroshi MIYANO, Masashi MITA, Wolfgang LINDNER, Kenji HAMASE

Journal of Pharmaceutical and Biomedical Analysis   115   123 - 129   2015.5

Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities Reviewed International journal

Hai HAN, Yurika MIYOSHI, Reiko KOGA, Masashi MITA, Ryuichi KONNO, Kenji HAMASE

Journal of Pharmaceutical and Biomedical Analysis   ( 116 )   47 - 52   2015.5

Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes Reviewed International journal

Masataka SUZUKI, Jumpei SASABE, Yurika MIYOSHI, Kenji HAMASE, Masaaki MATSUOKA, Nobuaki IMANISHI, Sadakazu AISO

Proceedings of the National Academy of Sciences of the United States of America   112   E2217 - E2224   2015.4

Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia Reviewed International journal

Takato ABE, Masataka SUZUKI, Jumpei SASABE, Shinichi TAKAHASHI, Miyuki UNEKAWA, Kyoko MASHIMA, Takuya IIZUMI, Kenji HAMASE, Ryuichi KONNO, Sadakazu AISO, Norihiro SUZUKI

Journal of Cerebral Blood Flow and Metabolism   34   1928 - 1935   2015.3

Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2 Reviewed International journal

Printip WONGTHAI, Kohei HAGIWARA, Yurika MIYOSHI, Pattama WIRIYASERMKUL, Ling WEI, Ryuichi OHGAKI, Itsuro KATO, Kenji HAMASE, Shushi NAGAMORI, Yoshikatsu KANAI

Cancer Science,   106   279 - 286   2015.3

Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane Reviewed International journal

Hiroshi HAMAMOTO, Makoto URAI, Kenichi ISHII, Jyunichiro YASUKAWA, Atmika PAUDEL, Motoki MURAI, Takuya KAJI, Takefumi KURANAGA, Kenji Hamase, Takashi KATSU, Jie SU, Tatsuo ADACHI, Ryuji UCHIDA, Hiroshi TOMODA, Maki YAMADA, Manabu SOUMA, Hiroki KURIHARA, Masayuki INOUE, Kazuhisa SEKIMIZU

Nature Chemical Biology   11 ( 2 )   127 - 133   2015.2

微量アミノ酸光学異性体の二次元HPLC-MS/MS分析を目指した各種パークル型キラル固定相の分離特性解析 Reviewed

鬼ヶ原弘久, 三次百合香, 三田真史, 濵瀬健司

九州大学中央分析センター報告   2014.12

Enantioselective determination of extraterrestrial amino acids using a two-dimensional chiral high-performance liquid chromatographic system Reviewed International journal

Kenji HAMASE, Yusuke NAKAUCHI, Yurika MIYOSHI, Reiko KOGA, Nao KUSANO, Hirohisa ONIGAHARA, Hiroshi NARAOKA, Hajime MITA, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Wolfgang LINDNER

Chromatography   35   103 - 110   2014.7

Localization of serine racemase and its role in the skin Reviewed International journal

Ran INOUE, Yoko YOSHIHISA, Yosuke TOJO, Chieko Okamura, Yuzo YOSHIDA, Jiro KISHIMOTO, Xinghua LUAN, Masahiko WATANABE, Mineyuki MIZUGUCHI, Yuko NABESHIMA, Kenji Hamase, Kenji MATSUNAGA, Tadamichi SHIMIZU, Hisashi MORI

Journal of Investigative Dermatology   134 ( 1618-1626 )   1618 - 1626   2014.2

Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers Reviewed International journal

Jumpei Sasabe, Masataka Suzuki, Yurika Miyoshi, Yosuke Tojo, Chieko Okamura, Sonomi Ito, Ryuichi Konno, Masashi Mita, Kenji Hamase, Sadakazu Aiso

PLOS ONE   9 ( e86504 )   2014.1

Chiral amino acid analysis of Japanese traditional Kurozu and the developmental changes during earthenware jar fermentation processes Reviewed International journal

Yurika MIYOSHI, Masanobu NAGANO, Shoto ISHIGO, Yusuke ITO, Kazunori HASHIGUCHI, Naoto HISHIDA, Masashi MITA, Wolfgang LINDNER, Kenji Hamase

Journal of Chromatography B   966 ( 187-192 )   187 - 192   2014.1

Two-dimensional high -performance liquid chromatographic determination of day-night variation of D-alanine in mammals and factors controlling the circadian changes Reviewed International journal

Sachise KARAKAWA, Yurika MIYOSHI, Ryuichi KONNO, Satoru KOYANAGI, Masashi MITA, shigehiro OHDO, Kenji HAMASE

Analytical and Bioanalytical Chemistry   403   8083 - 8091   2013.10

Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase Reviewed International journal

Yurika Miyoshi, Ryuichi Konno, Jumpei Sasabe, Kyoko Ueno, Yosuke Tojo, Masashi Mita, Sadakazu Aiso, Kenji Hamase

Amino Acids   43   1919 - 1931   2012.8

Enantioselective two-dimensional high-performance liquid chromatographic determination of N-methyl-D-aspartic acid and its analogues in mammals and bivalves Reviewed International journal

Reiko Koga, Yurika Miyoshi, Eiichi Negishi, Tsuneaki Kaneko, Masashi Mita, Wolfgang Lindner, Kenji Hamase

Journal of Chromatography A   1269   255 - 261   2012.8

哺乳類におけるキラルアミノ酸メタボロミクスを可能とする二次元ミクロHPLC一斉分析法の開発 Reviewed

三次百合香，東條洋介，韓　海，三田真史，浜瀬健司

分析化学   2012.6

Type 1 diabetes mellitus in mice increases hippocampal 1 D-serine in the acute phase after streptozotocin injection Reviewed International journal

Masataka SUZUKI, Jumpei SASABE, Shigeki FURUYA, Masashi MITA, Kenji HAMASE, Sadakazu AISO

Brain Research   2012.6

Preliminary organic compound analysis of microparticles returned from Asteroid 25143 Itokawa by the Hayabusa mission Reviewed International journal

H. NARAOKA, H. MITA, K. HAMASE, M. MITA, H. YABUTA, K. SAITO, K. FUKUSHIMA, F. KITAJIMA, S. A. SANDFORD, T. NAKAMURA, T. NOGUCHI, R. OKAZAKI, K. NAGAO, M. EBIHARA, H. YURIMOTO, A. TSUCHIYAMA, M. ABE, K. SHIRAI, M. UENO, T. YADA, Y. ISHIBASHI, T. OKADA, A. FUJIMURA, T. MUKAI, M. YOSHIKAWA, J. KAWAGUCHI

Geochemical Journal   46   2012.1

D-Amino acid oxidase controls motoneuron degeneration through D-serine Reviewed International journal

Jumpei SASABE, Yurika MIYOSHI, Masataka SUZUKI, Masashi MITA, Ryuichi KONNO, Masaaki MATSUOKA, Kenji HAMASE, Sadakazu AISO

Proceedings of the National Academy of Sciences of the United States of America   109   2012.1

Enantioselective micro-2D-HPLC determination of aspartic acid in the pineal glands of rodents with various melatonin contents Reviewed International journal

Hai HAN, Yurika MIYOSHI, Tsubasa OYAMA, Ryoko KONISHI, Masashi MITA, Kenji HAMASE

Journal of Separation Science   34   2011.12

Simultaneous two-dimensional HPLC determination of free D-serine and D-alanine in the brain and periphery of mutant rats lacking D-amino-acid oxidase Reviewed International journal

Yurika MIYOSHI, Kenji HAMASE, Tadashi OKAMURA, Ryuichi KONNO, Noriyuki KASAI, Yosuke TOJO, Kiyoshi ZAITSU,

Journal of Chromatography B   879   2011.11

HPLC determination of the distribution of D-amino acids and effects of ecdysis on alanine racemase activity in kuruma prawn Marsupenaeus japonicus Reviewed International journal

Naoko YOSHIKAWA, Waka ASHIDA, Kenji HAMASE, Hiroki ABE

Journal of Chromatography B   879   2011.11

Simultaneous determination of D-aspartic acid and D-glutamic acid in rat tissues and physiological fluids using a multi-loop two-dimensional HPLC procedure Reviewed International journal

Hai HAN, Yurika MIYOSHI, Kyoko UENO, Chieko OKAMURA, Yosuke TOJO, Masashi MITA, Wolfgang LINDNER, Kiyoshi ZAITSU, Kenji HAMASE

Journal of Chromatography B   879   2011.11

D-Serine regulates cerebellar LTD and motor coordination through the d2 glutamate receptor Reviewed International journal

Wataru KAKEGAWA, Yurika MIYOSHI, Kenji HAMASE, Shinji MATSUDA, Keiko MATSUDA, Kazuhisa KOHDA, Kyoichi EMI, Junko MOTOHASHI, Ryuichi KONNO, Kiyoshi ZAITSU, Michisuke YUZAKI

Nature Neuroscience   14   2011.4

皮膚におけるD-アミノ酸の存在とその生理活性 Reviewed

芦田 豊，東條洋介，島田正一郎，岡村智恵子，三田真史，浜瀬健司

BIO INDUSTRY   28   2011.2

Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain Reviewed International journal

Jung Hoon YANG, Akira WADA, Kazuyuki YOSHIDA, Yurika MIYOSHI, Tomoko SAYANO, Kayoko ESAKI, Masami O. KINOSHITA, Shozo TOMONAGA, Norihiro AZUMA, Masahiko WATANABE, Kenji HAMASE, Kiyoshi ZAITSU, Takeo MACHIDA, Albee MESSING, Shigeyoshi ITOHARA, Yoshio HIRABAYASHI, Shigeki FURUYA

The Journal of Biological Chemistry   285   2010.12

Japan Astrobiology Mars Project (JAMP): Search for microbes on the Mars surface with special interest in methane-oxidizing bacteria Reviewed International journal

Akihiko YAMAGISHI, Shin-ichi YOKOBORI, Yoshitaka YOSHIMURA, Masamichi YAMASHITA, Hirofumi HASHIMOTO, Takashi KUBOTA, Hajime YANO, Junichi HARUYAMA, Makoto TABATA, Kensei KOBAYASHI, Hajime HONDA, Yuichi UTSUMI, Tsunemasa SAIKI, Takashi ITOH, Atsuo MIYAKAWA, Kenji HAMASE, Takeshi NAGANUMA, Hajime MITA, Kenichi TONOKURA, Sho SASAKI, Hideaki MIYAMOTO

Biological Sciences in Space   24   2010.10

6,7-Difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid, a newly designed fluorescence enhancement-type derivatizing reagent for amino compounds Reviewed International journal

Junzo HIRANO, Kenji HAMASE, Hiroyuki MIYATA and Kiyoshi ZAITSU

Journal of Fluorescence   20   2010.3

Simultaneous determination of hydrophilic amino acid enantiomers in mammalian tissues and physiological fluids applying a fully automated micro-two-dimensional high-performance liquid chromatographic concept Reviewed International journal

Kenji HAMASE, Yurika MIYOSHI, Kyoko UENO, Hai HAN, Junzo HIRANO, Akiko MORIKAWA, Masashi MITA, Tsuneaki KANEKO, Wolfgang LINDNER and Kiyoshi ZAITSU

Journal of Chromatography A   1217   2010.2

Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection Reviewed International journal

Yurika MIYOSHI, Kenji HAMASE, Yosuke TOJO, Masashi MITA, Ryuichi KONNO and Kiyoshi ZAITSU

Journal of Chromatography B   2009.8

Simple and rapid genotyping of D-amino acid oxdase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis Reviewed International journal

Yosuke TOJO, Kenji HAMASE, Ryuichi KONNO, Satoru KOYANAGI, Shigehiro OHDO and Kiyoshi ZAITSU

Journal of Separation Science   2009.2

Enantioselective visualization of D-alanine in rat anterior pituitary gland: localization to ACTH-secreting cells Reviewed International journal

Sachise ETOH, Kenji HAMASE, Akiko MORIKAWA, Tomohiro OHGUSU and Kiyoshi ZAITSU

Analytical and Bioanalytical Chemistry   2009.1

Circadian changes of D-alanine and related compounds in rats and the effect of restricted feeding on their amounts Reviewed International journal

Akiko MORIKAWA, Kenji HAMASE, Yurika MIYOSHI, Satoru KOYANAGI, Shigehiro OHDO and Kiyoshi ZAITSU

Journal of Chromatography B   2008.11

Automated and simultaneous two-dimensional micro-high-performance liquid chromatographic determination of proline and hydroxyproline enantiomers in mammals Reviewed International journal

Yosuke TOJO, Kenji HAMASE, Minako NAKATA, Akiko MORIKAWA, Masashi MITA, Yutaka ASHIDA, Wolfgang LINDNER and Kiyoshi ZAITSU

Journal of Chromatography B   2008.11

Structural and photophysical properties of novel dual fluorescent compounds, 1-aryl-substituted 6-methoxy-4-quinolones Reviewed International journal

Junzo HIRANO, Kenji HAMASE, Takeyuki AKITA and Kiyoshi ZAITSU

Luminescence   2008.10

A ratiometric fluorescent chemosensor, 1,10-phenanthroline-4,7-dione, for anions in aqueous-organic media Reviewed International journal

Junzo HIRANO, Hiroyuki MIYATA, Kenji HAMASE and Kiyoshi ZAITSU

Tetrahedron Letters   2007.7

A genetic variant of the serine racemase gene is associated with schizophrenia Reviewed International journal

Yukitaka MORITA, Hiroshi UJIKE, Yuji TANAKA, Kyohei OTANI, Makiko KISHIMOTO, Akiko MORIO, Tatsuya KOTAKA, Yuko OKAHISA, Masayuki MATSUSHITA, Akiko MORIKAWA, Kenji HAMASE, Kiyoshi ZAITSU and Shigetoshi KURODA

Biological Psychiatry   2007.5

Alteration in D-Amino Acid Levels in the Brains of Mice and Rats After the Administration of D-Amino Acids Reviewed International journal

Akiko MORIKAWA, Kenji HAMASE, Tomomi INOUE, Ryuichi KONNO and Kiyoshi ZAITSU

Amino Acids   2007.1

High-throughput determination of free D-aspartic acid in mammals by enzyme immunoassay using apecific monoclonal antibody Reviewed International journal

Tomohiro OHGUSU, Kenji HAMASE, Hiroyuki TANAKA, Yukihiro SHOYAMA, and Kiyoshi ZAITSU

Analytical Biochemistry   2006.10

Evaluation of a simple and novel fluorescent anion sensor,4-quinolone,and modification of the emission color by substitutions based on molecular orbital calculations Reviewed International journal

Junzo HIRANO, Kenji HAMASE, and Kiyoshi ZAITSU

Tetrahedron   2006.10

Sensitive High-Performance Liquid Chromatographic Assay for D-Amino-Acid Oxidase Activity in Mammalian Tissues using a Fluorescent Non-Natural Substrate, 5-Fluoro-D-Tryptophan Invited Reviewed International journal

Kenji HAMASE, Reiko NAGAYASU, Akiko MORIKAWA, Ryuichi KONNO and Kiyoshi ZAITSU

Journal of Chromatography A   2006.2

Crystal Structure of 6-Methoxy-4-quinolone, C10H9NO2・2H2O Reviewed International journal

Junzo HIRANO, Kenji HAMASE, Takeyuki AKITA and Kiyoshi ZAITSU

Analytical Sciences   2005.1

哺乳類体内微量D-アミノ酸の選択的分析法の開発 Reviewed

浜瀬健司，財津　潔

BUNSEKI KAGAKU   2004.7

アンジオテンシン変換酵素阻害薬トランドラプリルおよびその活性代謝物トランドラプリラートの透析膜における吸着性および透過性の検討 Reviewed

財津　潔，浜瀬健司，林　宏美，永安玲子，福田紘子，冨田辰之介，森川亜希子

医学と薬学   2004.6

Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect Reviewed International journal

Takanori AKAGI, Kazami USHINOHAMA, Shoko IKESUE, Eiji YUKAWA, Shun HIGUCHI, Kenji HAMASE, Kiyoshi ZAITSU and Shigehiro OHDO

The Journal of Pharmacology and Experimental Therapeutics   308 ( 1 )   378 - 384   2004.1

Reversible Fluorescence Labeling of Amino Groups of Protein using Dansylaminomethylmaleic Anhydride Reviewed International journal

Kayo SAKATA, Kenji HAMASE and Kiyoshi ZAITSU

Journal of Chromatography B   769 ( 1 )   47 - 54   2002.3

シリンジ製剤ヒトエリスロポエチンの透析膜における吸着及び透過性 Reviewed

財津　潔，浜瀬健司，坂田佳代，井上朋美，山本貢史

医学と薬学   2001.9

Determination of Free D-Aspartic Acid, D-Serine and D-Alanine in the Brain of Mutant Mice Lacking D-Amino-Acid Oxidase Activity Reviewed International journal

Akiko MORIKAWA, Kenji HAMASE, Tomomi INOUE, Ryuichi KONNO, Akira NIWA and Kiyoshi ZAITSU

Journal of Chromatography B   757 ( 1 )   119 - 125   2001.6

Attomole analysis of melatonin by precolumn derivatization reversed-phase micro-HPLC Reviewed International journal

Tatsunosuke TOMITA, Kenji HAMASE, Hiromi HAYASHI and Kiyoshi ZAITSU

Chromatography   2001.1

トリプトファン誘導体を用いる新規高感度D-アミノ酸オキシダーゼ活性測定法 Reviewed

永安玲子，浜瀬健司，財津　潔

九州大学中央分析センター報告   2001.1

Reversed-phase HPLC of monosaccharides in glycoproteins derivatized with aminopyrazine with fluorescence detection Reviewed International journal

Wei WU, Kenji HAMASE, Masaru KIGUCHI, Koji YAMAMOTO and Kiyoshi ZAITSU

Analytical Sciences   16 ( 9 )   919 - 922   2000.9

Non-acidic matrix for the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of acidic-labile compounds Reviewed International journal

Yoshihito OHBA, Naomi KOTO, Kenji HAMASE and Kiyoshi ZAITSU

Analytical Sciences   16 ( 6 )   659 - 661   2000.6

Selective masking of amino groups during fluorescence derivatization in the presence of a molecular imprint polymer Reviewed International journal

Kenji HAMASE, Keizo IWASHITA and Kiyoshi ZAITSU

Analytical Sciences   16 ( 4 )   417 - 419   2000.4

Determination of pineal melatonin by precolumn derivatization reversed-phase high-performance liquid chromatography and its application to the study of circadian rhythm in rats and mice Reviewed International journal

Kenji HAMASE, Tatsunosuke TOMITA, Ayako KIYOMIZU and Kiyoshi ZAITSU

Analytical Biochemistry   279 ( 1 )   106 - 110   2000.3

Reversible fluorescence derivatization of amino groups using dansylaminomethylmaleic acid via its anhydride Reviewed International journal

Kayo SAKATA, Kenji HAMASE, Shigeki SASAKI, Minoru MAEDA and Kiyoshi ZAITSU

Analytical Sciences   15 ( 11 )   1095 - 1099   1999.11

Sensitive anion-exchange HPLC of aminopyrazine derivatives of saccharides having n-acetylated monosaccharide at the reducing end Reviewed International journal

Masaru KIGUCHI, Kenji HAMASE, Wei WU, Koji YAMAMOTO and Kiyoshi ZAITSU

Analytical Sciences   15 ( 9 )   903 - 905   1999.9

Heme-undecapeptide labeling on insulin for the immunoassay of insulin with chemiluminescence detection Reviewed International journal

Kiyoshi ZAITSU, Yoshitada KIMURA, Yoshihito OHBA, Kenji HAMASE, Yuji MOTOMURA, Minoru ITOSE and Masato ISHIYAMA

Analytical Sciences   15 ( 9 )   871 - 878   1999.9

Alteration in the D-amino acid content of the rat pineal gland under anesthesia Reviewed International journal

Kenji HAMASE, Hiroshi HOMMA, Yuki TAKIGAWA and Kazuhiro IMAI

Amino Acids   17 ( 3 )   277 - 283   1999.9

Enantio-selective derivatization of amino compounds in the presence of a molecular imprint polymer Reviewed International journal

Kenji HAMASE, Keizo IWASHITA and Kiyoshi ZAITSU

Analytical Sciences   15 ( 5 )   411 - 412   1999.5

Simple and rapid analytical method for carbapenems using capillary zone electrophoresis Reviewed International journal

Shoko TANIGICHI, Kenji HAMASE, Akio KINOSHITA and Kiyoshi ZAITSU

Journal of Chromatography B   727 ( 1-2 )   219 - 225   1999.4

Sensitive determination of melatonin by precolumn derivatization and reversed-phase high-performance liquid chromatography Reviewed International journal

Fumio IINUMA, Kenji HAMASE, Sayaka MATSUBAYASHI, Masaki TAKAHASHI, Mitsuo WATANABE and Kiyoshi ZAITSU

Journal of Chromatography A   835 ( 1-2 )   67 - 72   1999.3

エリスロポエチンの透析膜における吸着及び透過性 Reviewed

浜瀬健司，坂田佳代，井上朋美，山本貢史，財津　潔

臨牀透析   1999.1

アミノピラジン誘導体化単糖類のキャピラリー電気泳動分析 Reviewed

山本貢史，浜瀬健司，呉　薇，財津　潔

九州大学中央分析センター報告   1999.1

Aminopyrazine as a precolumn derivatizing reagent for fluorescence detection of monosaccharides in high-performance liquid chromatography Reviewed International journal

Kazuaki TACHIKI, Hideyuki YOSHIDA, Kenji HAMASE and Kiyoshi ZAITSU

Analytical Sciences   13 ( 3 )   509 - 512   1997.6

Regional distribution and postnatal changes of D-amino acids in rat brain Reviewed International journal

Kenji HAMASE, Hiroshi HOMMA, Yuki TAKIGAWA, Takeshi FUKUSHIMA, Tomofumi SANTA and Kazuhiro IMAI

Biochimica et Biophysica Acta   1997.4

A simple method for high recovery of proteins after sodium dodecyl sulfate curdlan gel electrophoresis Reviewed International journal

Kenji HAMASE and Hiroshi NAKAMURA

Analytical Sciences   1996.6

Curdlan gel as a bioinert support for the electrophoresis of biologically active proteins Reviewed International journal

Kenji HAMASE, Hiroshi NAKAMURA and Terumi NAKAJIMA

Analytical Sciences   1996.4

A fluorescent derivative of 4-thiouridine Reviewed International journal

Hikoya HAYATSU, Takeshi NAWAMURA, Takashi KUBO, Kazuo NEGISHI, Ryoya GOHDA, Kenji HAMASE and Kazuhiro Imai

Nucleic Acids Symposium Series   1994.1

Curdlan gel, evaluated as a polysaccharide support by electrophoresis of substituted benzenes Reviewed International journal

Kenji HAMASE, Hiroshi NAKAMURA and Terumi NAKAJIMA

Analytical Sciences   1993.12

Group separation of linear DNAs and circular DNAs by curdlan gel electrophoresis Reviewed International journal

Kenji HAMASE, Hiroshi NAKAMURA and Terumi NAKAJIMA

Analytical Sciences   1993.2

Sodium dodecyl sulfate curdlan gel electrophoresis system for proteins Reviewed International journal

Kenji HAMASE, Hiroshi NAKAMURA and Terumi NAKAJIMA

Analytical Sciences   1992.10

Curdlan gel as a promising support for electrophoresis Reviewed International journal

Kenji HAMASE, Hiroshi NAKAMURA and Terumi NAKAJIMA

Analytical Sciences   1991.10

パートナー分析化学Ⅱ 改定第3版

濵瀬 健司（Role：Joint author）

南江堂  2017.3 

物理系薬学Ⅲ．機器分析・構造決定

濵瀬 健司（Role：Sole author）

東京化学同人  2016.1 

Liquid Chromatography, Vol. 1-2, Amino Acids and Bioamine Separations

Yurika Miyoshi, Tsubasa Oyama, Reiko Koga, Kenji Hamase（Role：Joint author）

Elsevier, Amsterdam, The Netherlands  2013.1 

試料分析講座 アミノ酸・生体アミン分析

浜瀬健司他（日本分析化学会編）（Role：Joint author）

丸善出版  2012.6 

パートナー分析化学Ⅱ 改定第2版

浜瀬健司他（山口政俊，升島 努，能田 均編）（Role：Joint author）

南江堂  2012.3 

D-Amino acids -practical methods and protocols-, Vol. 1, Analytical methods for D-amino acids

Kenji HAMASE (edited by Ryuichi KONNO, Hans BRÜCKNER, Antimo D’ANIELLO, George FISHER, Noriko FUJII and Hiroshi HOMMA)（Role：Joint author）

Nova Science Publishers, New York, United States of America  2009.12 

薬学領域の分析化学

浜瀬健司他（財津　潔、鶴田泰人編）（Role：Joint author）

廣川書店  2009.4 

薬学領域の機器分析学

浜瀬健司他（財津　潔、鶴田泰人編）（Role：Joint author）

廣川書店  2009.3 

薬学分析科学の最前線

浜瀬健司他（日本薬学会物理系薬学部会・分析化学担当教員会議編）（Role：Joint author）

じほう  2009.3 

D-Amino acids: A new frontier in amino acids and protein research - practical methods and protocols

Kenji HAMASE (edited by Ryuichi KONNO, Hans BRÜCKNER, Antimo D’ANIELLO, George FISHER, Noriko FUJII and Hiroshi HOMMA)（Role：Sole author）

Nova Science Publishers, New York, United States of America  2007.1 

薬学の機器分析学　第２版

浜瀬健司他（財津　潔、山口政俊編）（Role：Joint author）

廣川書店  2003.4 

薬学の分析化学　第２版

浜瀬健司他（財津　潔、山口政俊編）（Role：Joint author）

廣川書店  2002.8 

薬学の分析化学

浜瀬健司他（財津　潔、山口政俊編）（Role：Joint author）

廣川書店  2001.2 

Modern derivatization methods for separation sciences

Kenji HAMASE (edited by Toshimasa Toyo'oka)（Role：Sole author）

John wiley and sons  1999.1 

薬学の機器分析学

浜瀬健司他（財津　潔編）（Role：Joint author）

廣川書店  1997.4 

マルチループ2D-ミクロHPLCを用いる哺乳類体内疎水性D-アミノ酸の一斉分析

浜瀬健司，三田真史，金子恒顕，財津　潔

日本分析化学会第55年会  2006.9 

Development of an enantio- and chemo-selective screening method for asparagine/aspartic acid and glutamine/glutamic acid residues in proteins International conference

Chiharu ISHII, Kanako TAKESHIMA, Takeyuki AKITA, Masashi MITA, Yusuke MURAKAMI, Tadashi UEDA, Kenji HAMASE

34th International Symposium on Pharmaceutical and Biomedical Analysis  2024.9 

マウス組織および生体液におけるセリン、スレオニンおよびアロスレオニンの三次元キラルHPLC分析

小柳出麻衣, 石井千晴, 秋田健行, 三田真史, 浜瀬健司

第36回バイオメディカル分析科学シンポジウム  2024.8 

Development of an analytical method discriminating D-asparagine/glutamine and D-aspartic acid/glutamic acid residues in proteins International conference

Chiharu ISHII, Kanako TAKESHIMA, Takeyuki AKITA, Masashi MITA, Yusuke MURAKAMI, Tadashi UEDA, Kenji HAMASE

The 6th International Conference of D-Amino Acid Reseach  2024.8 

Effect of temperature on the separation of NBD-chiral amino acids using a pirkle-type stationary phase and analysis of real-world samples International conference

Takuho KOZONO, Chiharu ISHII, Masashi MITA, Takeyuki AKITA, Kenji HAMASE

The 6th International Conference of D-Amino Acid Reseach  2024.8 

Development of a two-dimensional chiral hplc system for the simultaneous analysis of leucine chain isomers and their alteration in the plasma and urine of D-amino acid oxidase deficient rats International conference

Chiharu ISHII, Mayumi YAMABE, Yukiko SHIMIZU, Takeyuki AKITA, Masashi MITA, Tadashi OKAMURA, Kenji HAMASE

The 6th International Conference of D-Amino Acid Reseach  2024.8 

Two-dimensional HPLC determination of alanine, aspartic acid, glutamic acid and serine enantiomers in fermented beverages International conference

Kyoka ODA, Chiharu ISHII, Akira FUJII, Masashi MITA, Takeyuki AKITA, Masanobu NAGANO, Jen-Ai LEE, Kenji HAMASE

The 6th International Conference of D-Amino Acid Reseach  2024.8 

Development of a 3D-HPLC system for the determination of aliphatic chiral amino acids in the plasma ofchronic kidney disease patients International conference

Yuri NAGATA, Takeyuki AKITA, Chiharu ISHII, Mai OYAIDE, Masashi MITA, Masataka IKEDA, Tomomi IDE, Tomonori KIMURA, Kenji HAMASE

The 6th International Conference of D-Amino Acid Reseach  2024.8 

High-resolution 2D-HPLC analysis of asparagine/aspartate/glutamine/glutamate enantiomers and alteration of their urinary levels in D-aspartate oxidase deficient mice International conference

Riko OKABE, Takeyuki AKITA, Chiharu ISHII, Masashi MITA, Kenji HAMASE

The 6th International Conference of D-Amino Acid Reseach  2024.8 

Three dimensional HPLC analysis of D-Serine, D-Threonine and D-Allothreonine in the mouse tissues and physiological fluids International conference

Mai OYAIDE, Chiharu ISHII1, Takeyuki AKITA, Masashi MITA, Kenji HAMASE

The 6th International Conference of D-Amino Acid Reseach  2024.8 

Development of novel pirkle-type stationary phases having different length of spacers for selective analysis of D-amino acids International conference

Takeyuki AKITA, Chiharu ISHII, Masashi MITA, Kenji HAMASE

The 6th International Conference of D-Amino Acid Reseach  2024.8 

健常人および慢性腎臓病患者における血中アスパラギン・セリンの迅速三次元キラルHPLC分析

道清祐輝，小柳出麻衣，石井千晴，三田真史，秋田健行，池田昌隆，井手友美，木村友則，浜瀬健司

九州分析化学若手の会 第37回若手研究講演会および第42回夏季セミナー  2024.7 

タンパク質中のアスパラギン/アスパラギン酸および グルタミン/グルタミン酸残基の一斉キラル識別分析を可能とする前処理条件の検討

三ノ宮悠介，石井千晴，三田真史，秋田健行，植田　正，浜瀬健司

九州分析化学若手の会 第37回若手研究講演会および第42回夏季セミナー  2024.7 

生理的な条件で生じるマウスリゾチームAsn127の異性化と脱アミド化の解析

出田隼也，小山浩輔，吉田陽香，石谷奈緒，石井千晴，浜瀬健司，植田　正

第24回日本蛋白質科学会年会  2024.6 

アラニルアラニン光学異性体を対象とする高分離能二次元HPLC法の開発

渡邉楓雅，永田優凜，石井千晴，藤井　暁，三田真史，秋田健行，長野正信，浜瀬健司

第31回クロマトグラフィーシンポジウム  2024.6 

ヒト血液・尿中のアスパラギン・セリン鏡像異性体を対象とする迅速オンライン三次元HPLC分析法開発

道清祐輝，小柳出麻衣，石井千晴，三田真史，秋田健行，井手友美，浜瀬健司

第31回クロマトグラフィーシンポジウム  2024.6 

アスパラギン/アスパラギン酸およびグルタミン/グルタミン酸残基のホフマン転位を用いる一斉光学識別分析における反応生成物の精査

三ノ宮悠介，石井千晴，三田真史，秋田健行，植田　正，浜瀬健司

第31回クロマトグラフィーシンポジウム  2024.6 

Pirkle型固定相を用いるNBD-キラルアミノ酸の分離における分析温度変更と実試料分析への適用

小園拓歩，石井千晴，三田真史，秋田健行，浜瀬健司

第31回クロマトグラフィーシンポジウム  2024.6 

発酵飲料中Ala、Asp、GluおよびSerの二次元HPLCを用いるキラル識別含量解析

小田京香，石井千晴，藤井　暁，三田真史，秋田健行，長野正信，Jen-Ai LEE，浜瀬健司

第31回クロマトグラフィーシンポジウム  2024.6 

3μm微粒子充填Pirkle型カラムを用いる高分離機能二次元HPLC法開発とマウス尿中Asn/Asp/Gln/鏡像異性体の含量解析

岡部理子，秋田健行，石井千晴，三田真史，浜瀬健司

第31回クロマトグラフィーシンポジウム  2024.6 

ロイシン連鎖異性体を対象とする二次元キラルHPLC法の開発とD-アミノ酸酸化酵素欠損に伴う哺乳類血漿・尿中における含量変化解析

山部真弓，石井千晴，清水有紀子，三田真史，秋田健行，岡村匡史，浜瀬健司

第31回クロマトグラフィーシンポジウム  2024.6 

アスパラギン酸、アラニン、セリン、残基を対象とした二次元キラルLC-MS/MS法の開発と酸化タンパク質における異性化解析

村田快太，石井千晴，阿部真紗美，山部真弓，三田真史，秋田健行，山田健一，植田　正，浜瀬健司

第31回クロマトグラフィーシンポジウム  2024.6 

グルタミン酸鏡像異性体の迅速三次元HPLC分析法開発

久保和希，小柳出麻衣，石井千晴，三田真史，秋田健行，浜瀬健司

第31回クロマトグラフィーシンポジウム  2024.6 

三次元キラルHPLCを用いるリシンおよび代謝物のヒト血漿・尿中における含量解析

@松尾あかり，@古賀鈴依子，@三田真史，@井手友美，@吉田秀幸, @能田　均，@浜瀬健司

日本薬学会第144年会  2024.3 

ヒト体液中親水性D-アミノ酸の二次元HPLC分析と発酵食品摂取による影響

#近藤菜穂，#尾中孝彰，#小田京香，#長谷川美優，@石井千晴，@秋田健行，@三田真史，@井手友美, @浜瀬健司

日本薬学会第144年会  2024.3 

各種哺乳動物における尿中疎水性アミノ酸のキラル識別分析

#尾中孝彰，#近藤菜穂，#小田京香，#長谷川美優，@石井千晴，@清水有紀子，@岡村匡史，@山﨑真大，@秋田健行，@三田真史，@井手友美， @浜瀬健司

日本薬学会第144年会  2024.3 

老化・劣化タンパク質中の異性化アミノ酸解析を可能とする二次元キラルLC-MS/MS法開発

@石井千晴，@秋田健行，@三田真史，@村上祐介，@植田　正， @浜瀬健司

日本薬学会第144年会  2024.3 

グリシンおよび酸性アミノ酸を含有するジペプチドを対象とした二次元キラルHPLC分析法の開発

#江頭花奈，@秋田健行，#中川雄太，@石井千晴，@三田真史，@植田　正，@浜瀬健司

日本薬学会第144年会  2024.3 

高選択的三次元キラルHPLCを用いるアミノ酪酸構造異性体の生体内含量解析

@川添奈倫，@古賀鈴依子，@石井千晴，@三田真史，@井手友美，@吉田秀幸，@能田　均，@浜瀬健司

日本薬学会第144年会  2024.3 

三次元HPLCを用いるシトルリンおよびオルニチンのキラル識別生体内含量解析

@守田衣織，@古賀鈴依子，@石井千晴，@三田真史，@吉田秀幸，@能田　均，@浜瀬健司

日本薬学会第144年会  2024.3 

Chiral amino acid analysis for drug discovery and diagnosis Invited International conference

@Kenji HAMASE

39th International annual meeting in pharmaceutical science  2024.3 

アクリジニウムエステル化学発光（アクリジン部位のメチル化）

@中園　学，@浜瀬健司

生物発光化学発光研究会第38回学術講演会  2023.11 

Bis-acridinium ester誘導体を用いるH2O2及びカタラーゼ活性測定

@中園　学，@浜瀬健司

生物発光化学発光研究会第38回学術講演会  2023.11 

アラニン、アスパラギン酸、セリン、乳酸および3-ヒドロキシ酪酸を対象とする二次元キラルHPLC法開発とヒト生体液試料の分析

#坂元瞭太，#蔡　欣妙，@石井千晴，@秋田健行，@三田真史，@井手友美，@浜瀬健司

第34回クロマトグラフィー科学会議  2023.10 

グリシン含有ジペプチドを対象とする二次元キラルHPLC法開発

#横谷昌祐，@秋田健行，@石井千晴，@三田真史，@浜瀬健司

第34回クロマトグラフィー科学会議  2023.10 

光リアクター搭載多次元HPLCによるNBD-Trpの光学識別蛍光分析法開発

#山下愛絵，@石井千晴，@秋田健行，@根岸栄一，@井本啓史，@三田真史，@浜瀬健司

第34回クロマトグラフィー科学会議  2023.10 

加齢性疾患におけるキラルアミノ酸の含量変化と多次元LCによるスクリーニング法開発 Invited

@石井千晴，@秋田健行，@三田真史，@井手友美，@村上祐介，@木村友則， @浜瀬健司

日本分析化学会第72年会  2023.9 

哺乳類体内におけるヒスチジンおよびアルギニン鏡像異性体の三次元HPLC分析

#長谷川美優，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

日本分析化学会第72年会  2023.9 

二次元HPLCを用いる植物・食品中におけるAla、Asp、GluおよびSerのキラル識別含量解析

#小田京香，#長谷川美優，@石井千晴，@三田真史，@秋田健行，@浜瀬健司

日本分析化学会第72年会  2023.9 

ヒト血中におけるSer/Thr/aThrの三次元キラルHPLC分析法開発と腎不全の新規バイオマーカー探索

#小柳出麻衣，@石井千晴，@三田真史，@秋田健行，@井手友美，@木村友則，@浜瀬健司

日本分析化学会第72年会  2023.9 

アミノ酪酸構造異性体を対象とする三次元キラルHPLC分析法の開発とヒト尿中含量解析

@古賀鈴依子，@川添奈倫，@石井千晴，@三田真史，@井手友美，@吉田秀幸，@能田　均, @浜瀬健司

第17回D-アミノ酸学会学術講演会  2023.9 

三次元HPLCを用いる脂肪族キラルアミノ酸一斉分析法開発と慢性腎臓病患者における血漿中含量の解析

#永田優凜，@秋田健行，@石井千晴，#小柳出麻衣，@三田真史，@井手友美，@木村友則， @浜瀬健司

第17回D-アミノ酸学会学術講演会  2023.9 

微粒子充填型高分離能光学分割カラムを用いるAsn/Asp/Gln/Glu鏡像異性体の二次元HPLC分析法開発

#岡部理子，@秋田健行，@石井千晴，#中川雄太，@三田真史， @浜瀬健司

第17回D-アミノ酸学会学術講演会  2023.9 

直鎖脂肪族アミノ酸を有する新規高性能Pirkle型固定相の開発とキラルアミノ酸の網羅的二次元HPLC分析

#中川雄太，@秋田健行，@石井千晴，@三田真史，@浜瀬健司

第35回バイオメディカル分析科学シンポジウム  2023.7 

Pirkle型カラムにおける分析温度変更とNBD-アミノ酸鏡像異性体の分離挙動

#小園拓歩，#小柳出麻衣，@石井千晴，@三田真史，@秋田健行, @浜瀬健司

九州分析化学若手の会 第36回若手研究講演会および第41回夏季セミナー  2023.7 

二次元LC-MS/MSを用いるヒト血中D-アミノ酸の含量解析と新規腎機能マーカーの探索

@石井千晴，@秋田健行，@三田真史，@井手友美，@木村友則, @浜瀬健司

第35回バイオメディカル分析科学シンポジウム  2023.7 

生体・食品・宇宙試料におけるキラルアミノ酸ならびに類緑化合物の三次元・四次元HPLC分析

@浜瀬健司，@石井千晴，@秋田健行，@三田真史，@井手友美，@木村友則，@奈良岡　浩

第35回バイオメディカル分析科学シンポジウム  2023.7 

ヒスチジンおよびアルギニン鏡像異性体を対象とする三次元HPLC分析法の開発

#長谷川美優，@石井千晴，@秋田健行，@藤井　暁，@三田真史，@長野正信，@浜瀬健司

第35回バイオメディカル分析科学シンポジウム  2023.7 

ロイシン/イソロイシン/アロイソロイシン鏡像異性体を対象とする二次元HPLC分析法の開発とラット血漿および尿中含量の解析

#山部真弓，@石井千晴，@清水有紀子，@秋田健行，@三田真史，@岡村匡史，@浜瀬健司

第35回バイオメディカル分析科学シンポジウム  2023.7 

Three/four dimensional chiral HPLC analysis of amino acids in mammals; Their origins, regulation systems and diagnostic values Invited International conference

@Kenji HAMASE

33rd International Symposium on Pharmaceutical and Biomedical Analysis  2023.7 

Selective determination of D-amino acids in human plasma using a two-dimensional LC-MS/MS system toward early-diagnosis of chronic kidney disease International conference

@Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Tomonori KIMURA, @Kenji HAMASE

33rd International Symposium on Pharmaceutical and Biomedical Analysis  2023.7 

二次元LC-MS/MSシステムを用いるタンパク質中アスパラギン／グルタミン残基のキラル識別微量分析法開発と臨床試料への適用

@石井千晴，#竹島華菜子，@秋田健行，@三田真史，@村上祐介，@植田　正，@浜瀬健司

第30回クロマトグラフィーシンポジウム  2023.6 

崇高い芳香族アミノ酸を光学中心に有する高分離能Pirkle型キラル固定相の開発

@秋田健行，#小柳出麻衣，@石井千晴，@三田真史，@浜瀬健司

第30回クロマトグラフィーシンポジウム  2023.6 

迅速三次元キラルHPLCを用いる腎不全患者血中アスパラギン・セリンの含量解析

#道清祐輝，#小柳出麻衣，@石井千晴，@三田真史，@秋田健行，@井手友美，@木村友則，@浜瀬健司

第30回クロマトグラフィーシンポジウム  2023.6 

3 µm微粒子充填Pirkle型固定相の開発とマウス組織におけるD-アスパラギン酸含量の解析

#岡部理子，@秋田健行，@石井千晴，#中川雄太，@三田真史，@浜瀬健司

第30回クロマトグラフィーシンポジウム  2023.6 

脂肪族キラルアミノ酸を対象とする 高選択的三次元HPLC法の開発と ヒト血漿・尿中における含量解析

#永田優凜，@秋田健行，@石井千晴，#小柳出麻衣，@三田真史，井手友美，@浜瀬健司

第30回クロマトグラフィーシンポジウム  2023.6 

Development of an enantioselective three-dimensional HPLC system for the simultaneous determination of aliphatic amino acids in human plasma and urine International conference

#Yuri NAGATA, @Takeyuki AKITA, @Chiharu ISHII, #Mai OYAIDE, @Masashi MITA, @Tomomi IDE, @Kenji HAMASE

51st International Symposium on High- Performance Liquid Phase Separations and Related Techniques  2023.6 

Three dimensional HPLC determination of chiral amino acids in the Hayabusa2 return sample from Ryugu International conference

@Aogu FURUSHO, @Chiharu ISHII, @Takeyuki AKITA, @ Hiroshi NARAOKA, @Kenji HAMASE

51st International Symposium on High- Performance Liquid Phase Separations and Related Techniques  2023.6 

Development of a three-dimensional HPLC system for the determination of hydroxy amino acid enantiomers in the plasma of patients with renal disorder International conference

#Mai OYAIDE, @Chiharu ISHII, @Aogu FURUSHO, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Tomonori KIMURA, @Kenji HAMASE

51st International Symposium on High- Performance Liquid Phase Separations and Related Techniques  2023.6 

Multi-dimensional HPLC concepts integrating highly efficient enantioselective columns for the analysis of chiral amino acids in complicated real-world samples Invited International conference

@Kenji HAMASE, @Chiharu ISHII, @Aogu FURUSHO, @Takeyuki AKITA, @Masashi MITA, @Hiroshi NARAOKA, @Wolfgang LINDNER

51st International Symposium on High- Performance Liquid Phase Separations and Related Techniques  2023.6 

Screening of new diagnostic markers for chronic kidney disease focusing on chiral amino acids using a highly selective two-dimensional LC-MS/MS system International conference

@Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Tomonori KIMURA, @Kenji HAMASE

51st International Symposium on High- Performance Liquid Phase Separations and Related Techniques  2023.6 

生体・食品・宇宙試料におけるキラルアミノ酸の多次元HPLC分析 Invited

@浜瀬健司

Symposium on Molecular Chirality2023  2023.6 

Asn/Aspおよび Gln/Glu残基のキラル識別微量分析を可能とする重塩酸加水分解・二次元 LC-MS/MS法開発とタンパク質中 D型残基のスクリーニング

@石井千晴，#竹島華菜子，@秋田健行，@三田真史，@村上祐介，@植田　正，@浜瀬健司

第83回分析化学討論会  2023.5 

Three-dimensional HPLC determination of serine/threonine/allo-threonine enantiomers in the plasma of patients with chronic kidney disease International conference

#Mai OYAIDE, @Chiharu ISHII, @Aogu FURUSHO, @Masashi MITA, @Takeyuki AKITA, @Tomomi IDE, @Tomonori KIMURA, @Kenji HAMASE

日本薬学会第143年会次世代薬学アジアシンポジウム  2023.3 

微粒子充填Pirkle型光学分割カラムの開発とキラルアミノ酸の高性能分離

#岡部理子，@秋田健行，@石井千晴，#中川雄太，@三田真史，@浜瀬健司

日本薬学会第143年会  2023.3 

Pirkle型固定相によるNBD-アミノ酸光学分割に与える温度の影響

#小園拓歩，#古賀夢美，@石井千晴，@三田真史，@秋田健行，@浜瀬健司

日本薬学会第143年会  2023.3 

アスパラギン/グルタミン鏡像異性体および類縁体を含有するペプチドの分離挙動

#三ノ宮悠介，@石井千晴，#竹島華菜子，@三田真史，@秋田健行，@浜瀬健司

日本薬学会第143年会  2023.3 

アスパラギン・セリン鏡像異性体を対象とした迅速三次元HPLC法の開発

#道清祐輝，#小柳出麻衣，@石井千晴，@三田真史，@秋田健行，@井手友美，@浜瀬健司

日本薬学会第143年会  2023.3 

フルオラスキラル誘導体化LC-MS法による高選択的アミノ酸分析

@宮里ちひろ，@中武　樹，@川末慎葉，@古賀鈴依子，@秋田健行，@浜瀬健司，@吉田秀幸，@能田　均

日本薬学会第143年会  2023.3 

酸性アミノ酸およびN-メチル化酸性アミノ酸鏡像異性体を対象とする高感度・高選択的一斉分析法の開発

@清水美優，@川末慎葉，@古賀鈴依子，@三田真史，@井手友美，@吉田秀幸，@能田　均，@浜瀬健司

日本薬学会第143年会  2023.3 

エキシマー蛍光誘導体化を用いたカルノシンの高選択的二次元キラルHPLC分析法の開発

@新井杏奈，@守田羽吟，@川末慎葉，@古賀鈴依子，@三田真史，@浜瀬健司，@吉田秀幸，@能田　均

日本薬学会第143年会  2023.3 

キラルアミノ酸の多次元HPLC分析法開発と生体・食品・宇宙試料における含量解析 Invited

@浜瀬健司

新アミノ酸分析研究会第12回学術講演会  2022.12 

Multi-dimensional and enantioselective HPLC analysis of amino acids and related compounds - method development and application to real-world samples - Invited International conference

@Kenji HAMASE

RSC Tokyo International Conference 2022  2022.12 

多次元HPLCを用いる宇宙試料中のキラルアミノ酸分析 Invited

@浜瀬健司

第34回アミノ酸セミナー  2022.11 

メートル長高分離能光学分割カラムを用いるアラニンおよびセリン鏡像異性体の分析

#古賀夢美，@古庄　仰，@石井千晴，@藤井　暁，@秋田健行，@三田真史，@長野正信，@井手友美，@浜瀬健司

第33回クロマトグラフィー科学会議  2022.11 

二次元LC-MS/MSを用いるD-システイン残基の微量分析法開発とペプチド・タンパク質中の含量解析

#末吉里絵，@石井千晴，@秋田健行，@三田真史，@村上祐介，@植田　正，@浜瀬健司

第33回クロマトグラフィー科学会議  2022.11 

高分離能二次元キラルLC-MS/MSを用いるタンパク質中Asn/AspおよびGln/Glu残基分析

#竹島華菜子，@石井千晴，@秋田健行，@浜本　洋，@三田真史，@関水和久，@村上祐介，@植田　正，@浜瀬健司

第33回クロマトグラフィー科学会議  2022.11 

メートル長逆相カラムを装備した二次元HPLCの開発とキラルアミノ酸およびペプチド分析への適用

#濵田莉那，@石井千晴，@藤井　暁，@秋田健行，@三田真史，@長野正信，@浜瀬健司

第33回クロマトグラフィー科学会議  2022.11 

アラニンおよび乳酸鏡像異性体の一斉分析を可能とする二次元HPLC法の開発と実試料における含量解析

#山元一輝，@謝　金玲，@石井千晴，@藤井　暁，@秋田健行，@三田真史，@長野正信，@井手友美，@浜瀬健司

第33回クロマトグラフィー科学会議  2022.11 

多次元キラルHPLC法による慢性腎臓病の新規診断マーカー探索と実用化の展開 Invited

@石井千晴，@古庄　仰，#山﨑千夏，@秋田健行，@三田真史，@井手友美，@木村友則，@浜瀬健司

第６２回日本臨床化学会年次学術集会  2022.10 

生体・食品におけるSer/Thr/aThrの光学識別微量分析を可能とする三次元HPLC法の開発

#小柳出麻衣，@石井千晴，@古庄　仰，@秋田健行，@藤井　暁，@三田真史，@長野正信，@井手友美，@浜瀬健司

第19回次世代を担う若手のためのフィジカル・ファーマフォーラム  2022.9 

高選択的三次元HPLC分析法の設計開発と実試料中のキラルアミノ酸分析

#永田優凜，@古庄　仰，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

第19回次世代を担う若手のためのフィジカル・ファーマフォーラム  2022.9 

Selective determination of D-amino acids in the rat plasma and urine using a two-dimensional LC-MS/MS system and their regulation by D-amino acid oxidase International conference

@Chiharu ISHII, @Yukiko SHIMIZU, @Takeyuki AKITA, @Masashi MITA, @Tadashi OKAMURA, @Kenji HAMASE

12th International symposium on drug analysis & 32nd International symposium on pharmaceutical and biomedical analysis  2022.9 

Multi-dimensional HPLC analysis of chiral amino acids in complicated matrices including clinical, food and extraterrestrial samples Invited International conference

@Kenji HAMASE

12th International symposium on drug analysis & 32nd International symposium on pharmaceutical and biomedical analysis  2022.9 

Multi-dimensional HPLC analysis of chiral amino acids in complicated matrices including clinical, food and extraterrestrial samples Invited International conference

@Kenji HAMASE

12th International symposium on drug analysis & 32nd International symposium on pharmaceutical and biomedical analysis  2022.9 

高選択的三次元HPLCの開発を目的とした新規ミックスモードカラムの設計とNBD-アミノ酸鏡像異性体の分析

#永田優凜，@古庄　仰，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

第34回バイオメディカル分析科学シンポジウム  2022.9 

Ser/Thr/aThrのキラル識別分析を可能とする高選択的三次元HPLC法の開発とヒト血中含量の解析

#小柳出麻衣，@石井千晴，@古庄　仰，@秋田健行，@三田真史，@井手友美，@浜瀬健司

第34回バイオメディカル分析科学シンポジウム  2022.9 

セリンおよびスレオニンの光学識別微量分析法開発と生体・食品における含量解析

#小柳出麻衣，@石井千晴，@秋田健行，@藤井　暁，@三田真史，@長野正信，@井手友美，@浜瀬健司

九州分析化学若手の会第35回若手研究講演会および第40回夏季セミナー  2022.7 

二次元HPLCを用いる発酵食品中のヒスチジンおよびアルギニン鏡像異性体の分析

#長谷川美優，@石井千晴，@秋田健行，@藤井　暁，@三田真史，@長野正信，@浜瀬健司

九州分析化学若手の会第35回若手研究講演会および第40回夏季セミナー  2022.7 

キラルアミノ酸の網羅的微量分析を可能とする新規Pirkle型固定相の開発

#中川雄太，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

九州分析化学若手の会第35回若手研究講演会および第40回夏季セミナー  2022.7 

Simultaneous determination of chiral amino acids in the plasma and brain of DAO deficient rats using a highly selective two-dimensional LC-MS/MS system International conference

@Chiharu ISHII, @Yukiko SHIMIZU, @Takeyuki AKITA, @Masashi MITA, @Tadashi OKAMURA, @Kenji HAMASE

The 5th International conference of D-amino acid research  2022.7 

Enantioselective analysis of amino acids and related compounds using multi-dimensional HPLC and its medical applications Invited International conference

@Kenji HAMASE

The 5th International conference of D-amino acid research  2022.7 

Plasma D-amino acids are associated with gut microbial diversity and specific bacterial taxa in people living with and without HIV International conference

@Siew Hwei YAP, @Yi Xian ER, @Soo Ching LEE, @Cheng Siang LEE, @Aogu FURUSHO, @Chiharu ISHII, @Nurul Syuhada ZULHAMI, @Masashi MITA, @Kenji HAMASE, @Kok Hoong LEONG, @Yvonne Ai Lian LIM, @Reena RAJASURIAR

Asia-Pacific AIDS and Co-infections Conference  2022.6 

アミノ酪酸構造異性体を対象とする高選択的多次元キラルHPLC分析法の開発

@上田潔奈，@古賀鈴依子，@川末慎葉，@坂口洋平，@三田真史，@井手友美，@吉田秀幸，@能田　均，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

アラニンおよび乳酸の光学識別一斉分析を可能とする二次元HPLC法開発と実試料への適用

#山元一輝，#謝　金玲，@石井千晴，@秋田健行，@三田真史，@長野正信，@井手友美，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

Development of an enantioselective three-dimensional HPLC system for the determination of lactate, hydroxybutyrates and malate in human urine

#Hsin-Miao TSAI, #Chin-Ling HSIEH, @Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

第29回クロマトグラフィーシンポジウム  2022.6 

システイン残基のキラル識別微量分析を可能とする二次元LC-MS/MS法開発とタンパク質試料への適用

#末吉里絵，@石井千晴，@秋田健行，@三田真史，@植田　正，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

二次元LC-MS/MSを用いるAsn/AspおよびGln/Glu残基のキラル識別微量分析法開発とペプチド試料への適用

#竹島華菜子，@石井千晴，@秋田健行，@浜本　洋，@三田真史，@関水和久，@植田　正，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

二次元HPLCを用いる黒酢中ヒドロキシアミノ酸鏡像異性体の分析

#小柳出麻衣，@石井千晴，@藤井　暁, @秋田健行，@三田真史，@長野正信，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

塩基性アミノ酸を対象とする二次元キラルHPLC分析法開発と発酵食品における含量解析

#長谷川美優，@石井千晴，@秋田健行，@藤井　暁，@三田真史，@長野正信，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

高選択的多次元HPLCの開発を目的とした新規ミックスモードカラムの作製とNBD-アミノ酸の保持挙動評価

#永田優凜，@古庄　仰，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

Pirkle型キラル固定相を用いるロイシン/イソロイシン/アロイソロイシン鏡像異性体の一斉分析

#山部真弓，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

D-アミノ酸の微量分析を可能とする新規高性能Pirkle型キラル固定相の開発

#中川雄太，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

メートル長光学分割カラムを用いる黒酢中のキラルアミノ酸分析

#古賀夢美，#中川雄太，@石井千晴，@藤井　暁，@秋田健行，@三田真史，@長野正信，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

微粒子充填型メートル長逆相カラムの分離能評価およびキラルアミノ酸分析への適用

#濵田莉那，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

第29回クロマトグラフィーシンポジウム  2022.6 

キラルアミノ酸の識別定量を可能とする多次元HPLC分析法開発と腎不全における新規バイオマーカーの探索 Invited

@浜瀬健司

日本薬学会第142年会  2022.3 

二次元キラルHPLCを用いるカルノシンの高選択的分析法の開発

@守田羽吟，@川末慎葉，@古賀鈴依子，@坂口洋平，@三田真史，@浜瀬健司，@吉田秀幸，@能田　均

日本薬学会第142年会  2022.3 

直鎖脂肪族アミノ酸を有するPirkle型固定相の開発とNBD-アミノ酸鏡像異性体の分離

#中川雄太，#梶原雅貴，@秋田健行，@石井千晴，@三田真史，@浜瀬健司

日本薬学会第142年会  2022.3 

キラルアミノ酸の高選択的三次元HPLC分析を目的とする新規ミックスモードカラムの開発

#永田優凜，#古庄　仰，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

日本薬学会第142年会  2022.3 

各光リアクター搭載二次元HPLCを利用するNBD-Trp鏡像異性体の高感度分析法開発

#山下愛絵，@石井千晴，#古庄　仰，@秋田健行，@根岸栄一，@井本啓史，@三田真史，@浜瀬健司

日本薬学会第142年会  2022.3 

各種Pirkle型キラル固定相におけるロイシン連鎖異性体の分離挙動解析

#山部真弓，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

日本薬学会第142年会  2022.3 

高性能Pirkle型キラル固定相を用いるグリシン含有ジペプチドの光学分割

#横谷昌祐，@秋田健行，#山﨑千夏，@石井千晴，@三田真史，@浜瀬健司

日本薬学会第142年会  2022.3 

塩基性アミノ酸を対象とする高選択的二次元キラルHPLC分析法の開発

#長谷川美優，#守永　麟，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

日本薬学会第142年会  2022.3 

Asn/AspおよびGln/Glu残基を対象とする二次元キラルLC-MS/MS微量分析法開発と実試料における含量解析

#竹島華菜子，@石井千晴，@秋田健行，@浜本　洋，@三田真史，@関水和久，@植田　正，@浜瀬健司

日本薬学会第142年会  2022.3 

二次元LC-MS/MSを用いるシステイン残基のキラル識別微量分析法開発とタンパク質・ペプチドへの適用

#末吉里絵，@石井千晴，@秋田健行，@三田真史，@植田　正，@浜瀬健司

日本薬学会第142年会  2022.3 

二次元キラルHPLCを用いるアラニン、アスパラギン酸、セリン、乳酸および3-ヒドロキシ酪酸の同時分析法開発

#坂元瞭太，#謝　金玲，#山元一輝，@石井千晴，@秋田健行，@三田真史，@井手友美，@浜瀬健司

日本薬学会第142年会  2022.3 

ヒト血液および尿中におけるヒドロキシアミノ酸鏡像異性体の高分離能二次元HPLC分析法開発

#小柳出麻衣，#古庄　仰，@石井千晴，@秋田健行，@三田真史，@井手友美，@浜瀬健司

日本薬学会第142年会  2022.3 

セリンおよびアスパラギン酸の高選択的三次元キラルHPLC分析法開発とヒト血中含量解析

#梶原雅貴，@秋田健行，@石井千晴，@三田真史，@井手友美，@浜瀬健司

日本薬学会第142年会  2022.3 

Enantioselective analysis of amino acids and related compounds for biomarker screening using micro/narrowbore three-dimensional HPLC Invited International conference

@Kenji HAMASE

Pacifichem 2021  2021.12 

Determination of plasma D-amino acids in human and laboratory rodents with various D-amino acid oxidase activities using a two-dimensional HPLC-MS/MS system International conference

@Chiharu ISHII, @Yukiko SHIMIZU, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Tadashi OKAMURA, @Kenji HAMASE

Pacifichem 2021  2021.12 

多次元HPLCによるキラルアミノ酸の高選択的分析と医療応用 Invited

@浜瀬健司

第41回キャピラリー電気泳動シンポジウム  2021.12 

臨床診断を目的としたキラルアミノ酸の網羅的三次元HPLC分析法開発と新規腎機能マーカー探索への適用 Invited

#古庄　仰，@石井千晴，@秋田健行，@三田真史，@井手友美，@木村友則，@浜瀬健司

第32回クロマトグラフィー科学会議  2021.11 

ヒト血中セリンおよびアスパラギン鏡像異性体の迅速二次元HPLC分析法開発と慢性腎臓病早期診断への適用

#山﨑千夏，@石井千晴，@秋田健行，@三田真史，@井手友美，@木村友則，@浜瀬健司

第32回クロマトグラフィー科学会議  2021.11 

三次元HPLCを用いる微量酸性D-アミノ酸分析法開発と哺乳類における内在性含量の解析

#守永　麟，#古庄　仰，@石井千晴，@秋田健行，@三田真史，@浜瀬健司

第32回クロマトグラフィー科学会議  2021.11 

内在性キラルアミノ酸の選択的定量を可能とする二次元LC-MS/MSシステムの開発と哺乳類血中における含量解析

@石井千晴，@清水有紀子，@秋田健行，@三田真史，@井手友美，@岡村匡史，@浜瀬健司

クロマトグラフィー次世代技術セミナー2021  2021.10 

Enantioselective determination of lactate in vinegars including Japanese traditional kurozu samples and the developmental changes during fermentation processes

#Chin-Ling HSIEH, @Chiharu ISHII, @Takeyuki AKITA, @Akira FUJII,@ Masanobu NAGANO, @Masashi MITA, @Jen-Ai LEE, @Kenji HAMASE

クロマトグラフィー次世代技術セミナー2021  2021.10 

Two-dimensional chiral HPLC analysis of lactate, hydroxybutyrates and malate in mammalian physiological fluids and food samples

#Hsin-Miao TSAI, #Chin-Ling HSIEH, @Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Jen-Ai LEE, @Kenji HAMASE

クロマトグラフィー次世代技術セミナー2021  2021.10 

微量地球外試料におけるキラルアミノ酸分析を可能とする高選択的三次元HPLC法の開発

#古庄　仰，@石井千晴，@秋田健行，@三田真史，@奈良岡　浩，@浜瀬健司

クロマトグラフィー次世代技術セミナー2021  2021.10 

タンパク質中Asn/AspおよびGln/Glu残基の微量分析を可能とする高分離能二次元キラルLC-MS/MS法開発

#竹島華菜子，@石井千晴，@秋田健行，@三田真史，@植田　正，@浜瀬健司

クロマトグラフィー次世代技術セミナー2021  2021.10 

哺乳類血中キラルアミノ酸の精密定量を可能とする二次元LC-MS/MS法の開発とD-アミノ酸酸化酵素欠損による含量変化

@石井千晴，@清水有紀子，@秋田健行，@三田真史，@井手友美，@岡村匡史，@金野柳一，@浜瀬健司

第16回D-アミノ酸学会学術講演会  2021.9 

高選択的三次元HPLC分析法の開発と生体・宇宙試料におけるキラルアミノ酸精密定量

#古庄　仰，@石井千晴，@秋田健行，@三田真史，@井手友美，@木村友則，@奈良岡　浩，@浜瀬健司

第16回D-アミノ酸学会学術講演会  2021.9 

芳香族アミノ酸を有する新規高分離能Pirke型キラル固定相の開発とNBD-アミノ酸の光学分割

#小柳出麻衣，@秋田健行，#梶原雅貴，#古庄　仰，@石井千晴，@三田真史，@浜瀬 健司

第33回バイオメディカル分析科学シンポジウム  2021.9 

タンパク質中のシステイン残基を対象とするキラル識別微量分析法開発

#末吉里絵，@石井千晴，@秋田健行，@三田真史，@植田 正，@浜瀬 健司

第33回バイオメディカル分析科学シンポジウム  2021.9 

三次元キラルHPLCを用いるリジンおよび代謝物の生体内含量解析

@古賀鈴依子，@荒牧雄也，@三田真史，@井手友美，@坂口洋平，@吉田秀幸，@能田　均，@浜瀬 健司

第33回バイオメディカル分析科学シンポジウム  2021.9 

Development of a two-dimensional LC-MS/MS system for the selective determination of intrinsic chiral amino acids and application to mammalian plasma International conference

@Chiharu ISHII, @Yukiko SHIMIZU, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Tadashi OKAMURA, @Kenji HAMASE

31st International Symposium on Pharmaceutical and Biomedical Analysis  2021.8 

Enantioselective determination of lactate, hydroxybutyrates and malate in mammalian plasma using a two-dimensional chiral HPLC system International conference

#Hsin-Miao TSAI, #Chin-Ling HSIEH, @Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Jen-Ai LEE, @Kenji HAMASE

31st International Symposium on Pharmaceutical and Biomedical Analysis  2021.8 

Development of a high-performance three-dimensional HPLC system for the determination of Ser and Asp enantiomers in human physiological fluids International conference

#Masataka KAJIWARA, @Takeyuki AKITA, @Chiharu ISHII, @Masashi MITA, @Tomomi IDE, @Kenji HAMASE

31st International Symposium on Pharmaceutical and Biomedical Analysis  2021.8 

Enantioselective determination of lactate in various food samples including Japanese traditional amber rice vinegar and the developmental changes during fermentation processes International conference

#Chin-Ling HSIEH, @Chiharu ISHII, @Takeyuki AKITA, @Akira FUJII, @Masanobu NAGANO, @Masashi MITA, @Jen-Ai LEE, @Kenji HAMASE

31st International Symposium on Pharmaceutical and Biomedical Analysis  2021.8 

Development of a highly sensitive and selective three-dimensional HPLC system for the determination of chiral amino acids in carbonaceous meteorites International conference

#Aogu FURUSHO, @Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Hiroshi NARAOKA, @Kenji HAMASE

31st International Symposium on Pharmaceutical and Biomedical Analysis  2021.8 

Development of a two-dimensional chiral HPLC system for the simultaneous determination of lactate, hydroxybutyrates and malate

#Hsin-Miao TSAI, #Chin-Ling HSIEH, @Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Jen-Ai LEE, @Kenji HAMASE

第28回クロマトグラフィーシンポジウム  2021.6 

タンデムカラム二次元HPLCを用いるヒト血中セリン鏡像異性体の分析

#山﨑千夏，@石井千晴，@秋田健行，@三田真史，@井手友美，@浜瀬 健司

第28回クロマトグラフィーシンポジウム  2021.6 

Enantioselective analysis of lactate in Japanese traditional amber rice vinegar and the developmental changes during fermentation processes

#Chin-Ling HSIEH, @Chiharu ISHII, @Takeyuki AKITA, @Akira FUJII, @Masanobu NAGANO, @Masashi MITA, @Jen-Ai LEE, @Kenji HAMASE

第28回クロマトグラフィーシンポジウム  2021.6 

宇宙アミノ酸を対象とする三次元キラルHPLC分析法の開発と炭素質隕石試料への適用

#古庄　仰，@石井千晴，@秋田健行，@三田真史，@奈良岡　浩，@浜瀬 健司

第28回クロマトグラフィーシンポジウム  2021.6 

二次元LC-MS/MSシステムを用いる哺乳類血中キラルアミノ酸の精密含量解析

@石井千晴，@清水有紀子，@秋田健行，@三田真史，@井手友美，@岡村 匡史，@浜瀬 健司

第28回クロマトグラフィーシンポジウム  2021.6 

臨床診断を目的としたキラルアミノ酸の多次元HPLC法開発とヒト血液・尿中における含量解析

#古庄　仰，@石井千晴，@秋田健行，@三田真史，@木村友則，@井手友美，@浜瀬 健司

第69回質量分析総合討論会  2021.5 

Multi-dimensional HPLC analysis of D-amino acids and related compounds and its clinical　applications Invited

@Kenji HAMASE

第43回日本分子生物学会年会  2020.12 

ヒト血中キラルアミノ酸の精密定量を可能とする二次元LC-MS/MS法開発と腎機能診断への適用 Invited

#石井千晴，@秋田健行，@三田真史，@木村友則，@井手友美,@浜瀬健司

第31回クロマトグラフィー科学会議  2020.11 

三次元HPLCを用いる哺乳類体内の微量酸性D-アミノ酸分析

#守永　麟，#古庄　仰，#吉岡夏輝，@秋田健行，@三田真史，@浜瀬健司

第31回クロマトグラフィー科学会議  2020.11 

3D-HPLC determination of lactic acid enantiomers in food samples and alteration of their amounts in the plasma after ingesting fermented products

#Chin-Ling HSIEH, @Takeyuki AKITA, @Masanobu NAGANO, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

第31回クロマトグラフィー科学会議  2020.11 

塩基性アミノ酸の三次元キラルHPLC分析法開発と哺乳類尿中含量の解析

#植木大和，#古庄　仰，#吉岡夏輝，@秋田健行，@三田真史，@井手友美，@浜瀬健司

第31回クロマトグラフィー科学会議  2020.11 

タンデム光学分割カラムを利用するロイシン連鎖異性体の二次元HPLCキラル一斉分析法の開発

#堀田直利，@酒井健多，@秋田健行，@三田真史，@浜瀬健司

第31回クロマトグラフィー科学会議  2020.11 

キラルアミノ酸の迅速かつ選択的多次元HPLC分析を可能とする高性能Pirkle型固定相の開発

#梶原雅貴，#吉岡夏輝，@秋田健行，@三田真史，@浜瀬健司

第31回クロマトグラフィー科学会議  2020.11 

臨床診断を目的としたヒト血液・尿中キラルアミノ酸の網羅的三次元HPLC分析法開発

#古庄　仰，@秋田健行，@三田真史，@井手友美，@浜瀬健司

第31回クロマトグラフィー科学会議  2020.11 

タンパク質におけるAsn/Asp及びGln/Gluの一斉識別を可能とする二次元キラルLC-MS/MS法の開発

#田川茂奈，#石井千晴，@秋田健行，@浜本　洋，@三田真史，@関水和久，@植田　正，@浜瀬健司

第31回クロマトグラフィー科学会議  2020.11 

タンパク質／ペプチドにおけるプロリン残基および4位水酸化体の二次元キラルLC-MS/MS分析法開発

#岩﨑孔明，#石井千晴，@秋田健行，@東條洋介，@三田真史，@植田　正，,@浜瀬健司

第31回クロマトグラフィー科学会議  2020.11 

Chiral amino acid analysis using multi-dimensional HPLC and medical applications Invited International conference

@Kenji HAMASE

第二回台湾薬学合同学術研討会  2020.11 

Chiral analysis of amino acids and related compounds using multi-dimensional HPLC for medical applications Invited International conference

@Kenji HAMASE

Molecular Chirality Asia 2020 Online  2020.11 

エキシマー蛍光誘導体化を用いるリジンおよびオルニチンの高選択的二次元HPLC分析法開発と尿中含量解析

@古賀鈴依子,@木村奈生,@坂口洋平,@三田真史,@井手友美,@浜瀬健司,@吉田秀幸,@能田　均

第27回クロマトグラフィーシンポジウム  2020.6 

塩基性アミノ酸を対象とした三次元キラルHPLC分析法の高性能化とヒト尿中含量の解析

#植木大和，#古庄　仰，@吉岡夏輝，@秋田健行，@三田真史，@井手友美，@浜瀬健司

第27回クロマトグラフィーシンポジウム  2020.6 

種々の地球外試料におけるキラルアミノ酸の三次元HPLC分析

#古庄　仰，@秋田健行，@三田真史，@奈良岡　浩，@浜瀬健司

第27回クロマトグラフィーシンポジウム  2020.6 

三次元HPLCを用いる黒酢およびヒト血漿における乳酸鏡像異性体の定量

#謝　金玲，@秋田健行，@長野正信，@三田真史，@井手友美，@李　仁愛，@浜瀬健司

第27回クロマトグラフィーシンポジウム  2020.6 

二次元HPLC-MS/MSシステムによるヒトおよびD-アミノ酸酸化酵素欠損マウスの血漿中キラルアミノ酸含量解析

#石井千晴，@秋田健行，@三田真史，@井手友美，@浜瀬健司

第27回クロマトグラフィーシンポジウム  2020.6 

D-グルタミン酸シクラーゼ：D-グルタミン酸分解酵素の酵素学的性質の解析

@片根真澄，@有吉　真，@立石周平，@小岩井　祥，@高久薫子，@長井賢一郎，@中山香月，@齋藤康昭，@宮本哲也，@関根正恵，@三田真史，@浜瀬健司，@的場聖明，@加藤くみ子，@本間　浩

日本薬学会第140年会  2020.3 

NBD-トリプトファンの二次元キラルLC-MS/MS分析法開発と哺乳類体内含量の解析

#瀧澤宣郎，#石井千晴，@秋田健行，@三田真史，@井手友美,@浜瀬健司

日本薬学会第140年会  2020.3 

高性能Pirkle型キラル固定相の開発とNBD-アミノ酸の光学分割能評価

#梶原雅貴，#吉岡夏輝，@秋田健行，@三田真史，,@浜瀬健司

日本薬学会第140年会  2020.3 

哺乳類体内の微量D-セリン分析を目的とするタンデムカラム二次元キラルHPLC法開発

#山﨑千夏，#吉岡夏輝，@秋田健行，@三田真史，@井手友美,@浜瀬健司

日本薬学会第140年会  2020.3 

生体内酸性D-アミノ酸の微量分析を可能とする三次元HPLC法開発

#守永　麟，#吉岡夏輝，#古庄　仰，@秋田健行，@三田真史，@浜瀬健司

日本薬学会第140年会  2020.3 

多次元液体クロマトグラフィーによるキラルアミノ酸分析基盤技術開発とその医療応用に関する研究 Invited

@浜瀬健司

第30回クロマトグラフィー科学会議  2019.12 

2D-HPLC determination of serine, alanine and aspartic acid enantiomers as their DBD derivatives in the human physiological fluids and food samples

#Karina Akemy IKEJIRI, #Aogu FURUSHO, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Kenji HAMASE

第30回クロマトグラフィー科学会議  2019.12 

含硫アミノ酸光学異性体の三次元HPLC分析法開発と哺乳類血中および尿中含量解析

#佐藤根詩織，@秋田健行，@三田真史，@井手友美，@浜瀬健司

第30回クロマトグラフィー科学会議  2019.12 

新規蛍光誘導体化試薬NBD-COOSuを用いるキラルアミノ酸の三次元HPLC分析法開発と哺乳類体内含量の解析

#二井屋田美樹，@秋田健行，@三田真史，@浜瀬健司

第30回クロマトグラフィー科学会議  2019.12 

エキシマー蛍光誘導体化によるオルニチン・リジンの高選択的二次元キラルHPLC分析法の開発

@木村奈生，@古賀鈴依子，@坂口洋平，@三田真史，@井手友美，@浜瀬健司

第30回クロマトグラフィー科学会議  2019.12 

リジンおよび代謝物を対象とする高感度・高選択的多次元キラルHPLC分析法の開発

@佐藤優衣，@古賀鈴依子，@坂口洋平，@三田真史，@井手友美，@吉田秀幸，@能田　均，@浜瀬健司

第30回クロマトグラフィー科学会議  2019.12 

LC-MS/MSによるβ作動薬一斉分析法の開発と畜産食品中の残留実態

#林　孝子，@宮澤眞紀，@浜瀬健司

第30回クロマトグラフィー科学会議  2019.12 

シトルリン及びオルニチンを対象とする三次元キラルHPLC分析法の開発とD-アミノ酸酸化酵素欠損に伴う尿中含量変化解析

@古賀鈴依子，@坂口洋平，@三田真史，@吉田秀幸，@能田　均，@浜瀬健司

第30回クロマトグラフィー科学会議  2019.12 

Multi-dimensional chiral HPLC analysis of amino acids and related compounds in real world samples International conference

@Kenji HAMASE

49th International Symposium on High Performance Liquid Phase Separations and Related Techniques  2019.12 

Enantioselective three-dimensional HPLC determination of amino acids in carbonaceous meteorites International conference

#Aogu FURUSHO, @Takeyuki AKITA, @Masashi MITA, @Hiroshi NARAOKA, @Kenji HAMASE

49th International Symposium on High Performance Liquid Phase Separations and Related Techniques  2019.12 

Development of a validated three-dimensional chiral HPLC system for the determination of lactate and 3-hydroxybutyrate in human plasma International conference

#Chin-Ling HSIEH, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

49th International Symposium on High Performance Liquid Phase Separations and Related Techniques  2019.12 

Two-dimensional HPLC-MS/MS determination of intrinsic chiral amino acids in the plasma of mammals with various D-amino acid oxidase activities International conference

#Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Kenji HAMASE

49th International Symposium on High Performance Liquid Phase Separations and Related Techniques  2019.12 

Development of a three-dimensional HPLC system for the enantioselective determination of urea-cycle amino acids in mammalian urine International conference

@Reiko KOGA, @Yohei SAKAGUCHI, @Masashi MITA, @Tomomi IDE, @Hideyuki YOSHIDA, @Hitoshi NOHTA, @Kenji HAMASE

49th International Symposium on High Performance Liquid Phase Separations and Related Techniques  2019.12 

高選択的三次元HPLC法の開発と炭素質隕石中のキラルアミノ酸分析

#古庄　仰，@秋田健行，@三田真史，@奈良岡　浩,@浜瀬健司

アストロバイオロジーワークショップ2019  2019.11 

アクリジニウムエステル誘導体化学発光：アクリジン部位2及び7位の置換基効果

@中園　学，@南部伸孝，@秋田健行,@浜瀬健司

生物発光化学発光研究会第35回学術講演会  2019.10 

キラルアミノ酸の識別定量を可能とする多次元HPLC分析法開発と創薬・診断への展開 Invited

@浜瀬健司

第59回日本臨床化学会年次学術集会  2019.9 

Enantioselective and multi-dimensional HPLC analysis of amino acids as their free/protein bound forms for the screening of novel biomarkers Invited International conference

@Kenji HAMASE

30th International Symposium on Pharmaceutical and Biomedical Analysis  2019.9 

Development of a highly selective two-dimensional HPLC-MS/MS system for the screening of intrinsic D-amino acids in human clinical samples International conference

#Chiharu ISHII, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE,@Kenji HAMASE

30th International Symposium on Pharmaceutical and Biomedical Analysis  2019.9 

Determination of urea-cycle-related amino acid enantiomers in human physiological fluids using a three-dimensional HPLC system International conference

@Reiko KOGA, @Haruka KAJIKI, @Yohei SAKAGUCHI, @Masashi MITA, @Tomomi IDE, @Hideyuki YOSHIDA, @Hitoshi NOHTA, @Kenji HAMASE,

The 4th International Conference of D-Amino Acid Research  2019.9 

The intra-body dynamics of D-serine reflects kidney function and disease International conference

@Atsushi HESAKA, @Shinsuke SAKAI, @Kenji HAMASE, @Tatsuhiko IKEDA, @Rakan MATSUI, @Masashi MITA, @Masaru HORIO, @Yoshitaka ISAKA, @Tomonori KIMURA

The 4th International Conference of D-Amino Acid Research  2019.9 

Rapid two-dimensional HPLC analysis of D-serine in the human plasma using a high-performance chiral stationary phase International conference

#Natsuki YOSHIOKA, @Shoto ISHIGO, @Takeyuki AKITA, @Masashi MITA, @Kenji HAMASE

The 4th International Conference of D-Amino Acid Research  2019.9 

Enantioselective analysis of lactate and 3-hydroxybutyrate in human samples using a selective and stable 3D-HPLC system International conference

#Chin-Ling HSIEH, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

The 4th International Conference of D-Amino Acid Research  2019.9 

Chiral recognition mechanism of pirkle-type stationary phases in D-amino acid analyses International conference

@Takeyuki AKITA, #Natsuki YOSHIOKA,@Masashi MITA, @Kenji HAMASE

The 4th International Conference of D-Amino Acid Research  2019.9 

Serum D-serine accumulation after proximal renal tubular damage involves neutral amino acid transporter Asc-1 International conference

@Yusuke GONDA,@Masataka SUZUKI, @Marina YAMADA, @Arno A. VANDEBROEK, @Masashi MITA, @Kenji HAMASE, @Masato YASUI, @Jumpei SASABE

The 4th International Conference of D-Amino Acid Research  2019.9 

Determination of urinary lactate and 3-hydroxybutyrate enantiomers in nephrotoxic serum nephritis mice with saikosaponin C treatment International conference

@Po-Yeh LIN, #Chin‐Ling HSIEH, @Chia-Yu LIN, @Shih-Ming CHEN, @Shiow-Yunn SHEU, @Kenji HAMASE, @Jen-Ai LEE

The 4th International Conference of D-Amino Acid Research  2019.9 

Establish of a new D-amino acid oxidase (Dao) deficient rat International conference

@Yukiko SHIMIZU, @Reiko YANOBU-TAKANASHI, @Kenji HAMASE

The 4th International Conference of D-Amino Acid Research  2019.9 

Metabolism of microbial D-amino acids in mammals International conference

@Jumpei SASABE, @Masataka SUZUKI, @Yusuke GONDA, #Chiharu ISHII, @Maiko NAKANE, @Masashi MITA, @Kenji HAMASE

The 4th International Conference of D-Amino Acid Research  2019.9 

臨床試料におけるキラルアミノ酸高選択的スクリーニングを可能とする二次元HPLC-MS/MSシステムの開発

#石井千晴，@秋田健行，@三田真史,@井手友美,@浜瀬健司

第17回次世代を担う若手のためのフィジカルファーマフォーラム  2019.9 

Determination of phenylalanine enantiomers in mammalian plasma and urine using two-dimensional HPLC

#Sui-Wen HSIAO, ＃Chiharu ISHII,＃ Aogu FURUSHO, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE,@Ching-Kuo LEE, @Kenji HAMASE

第32回バイオメディカル分析科学シンポジウム  2019.8 

キラルアミノ酸の高選択的二次元HPLC-MS/MS法開発と臨床・食品・タンパク質試料への適用

#石井千晴，@秋田健行，@長野正信，@三田真史,@井手友美,@浜瀬健司

第32回バイオメディカル分析科学シンポジウム  2019.8 

LC-MS/MS/MSによる豚肝臓中のクレンブテロール分析

#林　孝子，@藤巻照久，@宮澤眞紀，@浜瀬健司

第32回バイオメディカル分析科学シンポジウム  2019.8 

三次元HPLCを用いる哺乳類尿中塩基性アミノ酸のキラル識別分析

#植木大和，#古庄　仰，#吉岡夏輝，@秋田健行，@三田真史，@浜瀬健司

第37回九州分析化学若手の会　夏季セミナー  2019.7 

ロイシン連鎖異性体のキラル一斉分析を可能とする固定相の探索と分離条件の確立

#堀田直利,#吉岡夏輝,#酒井健多,@秋田健行,@三田真史,@浜瀬健司

第37回九州分析化学若手の会　夏季セミナー  2019.7 

Multi-dimensional HPLC determination of lactate and 3-hydroxybutyrate enantiomers and application to human physiological fluids

#Chin-Ling HSIEH, @ Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

第37回九州分析化学若手の会　夏季セミナー  2019.7 

Multi-dimensional HPLC analysis of chiral α-amino acids and carboxylic acids in extraterrestrial materials International conference

@Kenji HAMASE,#Aogu FURUSHO, #Chin-Ling HSIEH, @Reiko KOGA, @Takeyuki AKITA, @Masashi MITA, @Hiroshi NARAOKA, @Wolfgang LINDNER

31st International Symposium on Chirality  2019.7 

Design and development of a highly selective chiral 3D-HPLC system for the determination of lactate and 3-hydroxybutyrate enantiomers in human physiological fluids International conference

#Chin-Ling HSIEH, @ Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

31st International Symposium on Chirality  2019.7 

Enantioselective determination of lactate and 3-hydroxybutyrate in human clinical samples using a 3D-HPLC system

#Chin-Ling HSIEH, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

第56回化学関連支部合同九州大会  2019.7 

キラルアミノ酸分析におけるPirkle型固定相の分子認識機構解析

@秋田健行，#吉岡夏輝，#山崎千夏，@三田真史，@浜瀬健司

第56回化学関連支部合同九州大会  2019.7 

アルカリ及び触媒の添加を必要としないH2O2の化学発光測定

@中園　学，@南部伸孝，@秋田健行，@浜瀬健司

第56回化学関連支部合同九州大会  2019.7 

Three-dimensional HPLC analysis of chiral amino acids, peptides and carboxylic acids in human clinical samples International conference

@Kenji HAMASE,@ Reiko KOGA, @Masashi MITA, @Tomomi IDE, @Wolfgang LINDNER

48th International Symposium on High-Performance Liquid Phase Separations and Related Techniques  2019.6 

Three-dimensional chiral HPLC analysis of extraterrestrial amino acids in carbonaceous chondrites International conference

#Aogu FURUSHO, @Takeyuki AKITA, @Masashi MITA, @Hiroshi NARAOKA, @Kenji HAMASE

48th International Symposium on High-Performance Liquid Phase Separations and Related Techniques  2019.6 

多次元HPLCによるアミノ酸のキラル識別定量と医療応用 Invited

@浜瀬健司

モレキュラー・キラリティー2019  2019.6 

鏡像異性体を識別する全自動二次元HPLC-MS/MSシステムの開発と発酵食品におけるキラルアミノ酸の高選択的含量解析

#石井千晴，@秋田健行，@長野正信，@三田真史，@浜瀬健司

モレキュラー・キラリティー2019  2019.6 

Three-dimensional HPLC determination of lactate and 3-hydroxybutyrate enantiomers in mammalian urine

#Chin-Ling HSIEH, @Takeyuki AKITA, @Masashi MITA, @Tomomi IDE, @Jen-Ai LEE, @Kenji HAMASE

第26回クロマトグラフィーシンポジウム  2019.6 

塩基性アミノ酸を対象とした三次元キラルHPLC分析法の開発

＃植木大和，#古庄　仰，#吉岡夏輝，@秋田健行，@三田真史，@浜瀬健司

第26回クロマトグラフィーシンポジウム  2019.6 

ロイシン連鎖異性体の網羅的キラル分析を可能とする固定相の探索

＃堀田直利，#吉岡夏輝,#酒井健多，@秋田健行，@三田真史，@浜瀬健司

第26回クロマトグラフィーシンポジウム  2019.6 

三次元HPLCを用いる地球外試料中のキラルアミノ酸分析

＃古庄　仰，@秋田健行，@三田真史，@奈良岡　浩，@浜瀬健司

第79回分析化学討論会  2019.5 

高性能二次元キラルHPLCを用いるヒト血中D-Serの迅速分析

#吉岡夏輝，@石郷翔人，@秋田健行，@三田真史, @浜瀬健司

第79回分析化学討論会  2019.5 

疎水性アミノ酸を対象とする三次元キラルHPLC分析法の開発

#田中優光，@秋田健行，@三田真史，@浜瀬健司

第79回分析化学討論会  2019.5 

Chiral amino acid analysis using 2D/3D-HPLC for the screening of functional molecules and biomarkers Invited International conference

@Kenji HAMASE

9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)  2019.3