Updated on 2025/09/29

Information

 

写真a

 
JUTANOM MIRINTHORN
 
Organization
Faculty of Pharmaceutical Sciences Department of Chemo-Pharmaceutical Sciences Assistant Professor
School of Pharmaceutical Sciences Department of General Pharmaceutical Sciences（Concurrent）
Faculty of Pharmaceutical Sciences （Concurrent）
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926426623
Profile
 Investigation of the functions of Phosphatidylethanolamine head modifications in lipid peroxidation and diseases April 2024-present  Developed detection and purification techniques for oxidized phospholipids and studied their effects on lipid peroxidation-related diseases. April 2023 – Present  Conducting research on lipid peroxidation products (LPO) and their roles in various diseases. October 2022 – Present  Developed detection methods and purification techniques for sphingolipids and their oxidation products using mass spectrometry. October 2019 – September 2022  Investigated the health-promoting effects of dietary sphingolipids, particularly GlcCer from plants and other sources, focusing on intestinal health. October 2017 – September 2019  Explored the effects of GlcCer and sphingolipid fractions from Golden oyster mushroom (Pleurotus citrinopileatus) on apoptosis induced by inflammatory stress in an in vitro intestinal model. October 2017 – September 2019  Developed cloning and characterization methods for Glutamic acid dehydrogenase (Glu-DH) and Glutamic acid decarboxylase (GAD) to facilitate Gamma-aminobutyric acid (GABA) production.
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Research Areas

  • Life Science / Applied molecular and cellular biology

  • Life Science / Functional biochemistry

  • Life Science / Pharmaceutical chemistry and drug development sciences

  • Life Science / Food sciences

Degree

  • Doctoral degree （ 2022.9 Tohoku University ）

  • Master's degree （ 2019.9 Obihiro University of Agriculture and Veterinary Medicine ）

  • Bachelor's degree （ 2017 Mahidol University ）

Research History

  • Kyushu University Department of Molecular Pathobiology Faculty of Pharmaceutical Sciences, Kyushu University Assistant Professor 

    2023.4 - Present

  • Tohoku University Graduate School of Agricultural Sciences Assistant Professor (In charge of graduate school) 

    2022 - 2023

  • Assistant professor, Tohoku University   

Education

  • Tohoku University    

    2022.9

Research Interests・Research Keywords

  • Research theme： Investigation of the functions of Phosphatidylethanolamine head modifications in lipid peroxidation and diseases

    Keyword： Lipid peroxidation, Phospholipids, Head modification

    Research period： 2024 - Present

  • Research theme： Development of detection method and purification techniques of oxidized phospholipids and their effects on lipid peroxidation-related diseases.

    Keyword： lipid peroxidation, mass spectrometry, oxidation

    Research period： 2023.5 - 2024.5

  • Research theme： Research on lipid peroxidation products (LPO) and their functions in various diseases.

    Keyword： lipid peroxidation, mass spectrometry, oxidation

    Research period： 2023.4 - 2025.3

Papers

  • Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization

    Saimoto, Y; Kusakabe, D; Morimoto, K; Matsuoka, Y; Kozakura, E; Kato, N; Tsunematsu, K; Umeno, T; Kiyotani, T; Matsumoto, S; Tsuji, M; Hirayama, T; Nagasawa, H; Uchida, K; Karasawa, S; Jutanom, M; Yamada, KI

    NATURE COMMUNICATIONS   16 ( 1 )   3554   2025.4   （ eISSN:2041-1723 ）

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    Language：English   Publisher：Nature Communications  

    Ferroptosis, a form of cell death instigated by iron-dependent lipid peroxidation reactions (LPO), is emerging as a promising therapeutic target for cancer. While the mechanisms governing LPO induction and suppression have gradually been unveiled, questions persist regarding the specific cellular location of LPO and the utilization of iron in driving cell death. A comprehensive understanding of these aspects holds significant potential for advancing therapeutic applications in disease management. Here, we show lysosomal LPO in the initiation of ferroptosis, leveraging the hidden abilities of fluorescent detection probes. Intra-lysosomal LPO triggers iron leakage, fostering cell-wide LPO by augmenting lysosomal membrane permeabilization (LMP). Conversely, cell lines with low susceptibility to ferroptosis do not exhibit LMP. This deficiency is rectified by the concurrent administration of chloroquine, leading to LMP induction and subsequent cell death. These findings underscore enhancing LMP induction efficacy as a strategic approach to surmount resistance to therapies in cancer.

    DOI： 10.1038/s41467-025-58909-w

    Web of Science

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    PubMed

  • Analysis of oxidized glucosylceramide and its effects on altering gene expressions of inflammation induced by LPS in intestinal tract cell models Reviewed

    Jutanom, M; Kato, S; Yamashita, S; Toda, M; Kinoshita, M; Nakagawa, K

    SCIENTIFIC REPORTS   13 ( 1 )   22537   2023.12   （ ISSN:2045-2322 ）

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Scientific Reports  

    Glucosylceramide (GlcCer) belongs to sphingolipids and is found naturally in plant foods and other sources that humans consume daily. Our previous studies demonstrated that GlcCer prevents inflammatory bowel disease both in vitro and in vivo, whose patients are increasing alarmingly. Although some lipids are vulnerable to oxidation which changes their structure and activities, it is unknown whether oxidative modification of GlcCer affects its activity. In this research, we oxidized GlcCer in the presence of a photosensitizer, analyzed the oxide by mass spectrometric techniques, and examined its anti-inflammatory activity in lipopolysaccharide (LPS)-treated differentiated Caco-2 cells as in vitro model of intestinal inflammation. The results showed that GlcCer is indeed oxidized, producing GlcCer hydroperoxide (GlcCerOOH) as a primary oxidation product. We also found that oxidized GlcCer preserves beneficial functions of GlcCer, suppressing inflammatory-related gene expressions. These findings suggested that GlcCerOOH may perform as an LPS recognition antagonist to discourage inflammation rather than induce inflammation.

    DOI： 10.1038/s41598-023-49521-3

    Web of Science

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    PubMed

  • Identification of novel oxidized phospholipids that activate platelet-activating factor receptor using HPLC fractionation and comprehensive LC-MS/MS analysis

    Kozakura, E; Ueno, R; Yamashita, T; Hashidate-Yoshida, T; Shindou, H; Jutanom, M; Morimoto, K; Yamada, K

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   765   151858   2025.6   （ ISSN:0006-291X eISSN:1090-2104 ）

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    Language：English   Publisher：Biochemical and Biophysical Research Communications  

    Platelet-activating factor receptor (PAFR) is involved in various physiological processes, including the immune system and inflammatory responses. In addition to PAF, several oxidized phospholipids have been shown to act as ligands for PAFR. We have previously developed a comprehensive analysis method for oxidized phospholipids, and in this study, we employed this method to test whether additional oxidized phospholipids can activate PAFR. From an oxidized phosphatidylcholine mixture, we identified that 1-palmitoyl-2-(4′-oxo-butanoyl)-sn-glycero-3-phosphocholine (POBPC) functions as a novel PAFR activator, using preparative HPLC and comprehensive LC-MS/MS analysis of fractionated oxidized phospholipids. Next, multiple assays confirmed that POBPC acts as a bona fide PAFR agonist. The H248W mutation of PAFR attenuated the response to POBPC. Finally, POBPC induced phosphorylation of extracellular signal-regulated kinase in mouse peritoneal macrophages, which endogenously express PAFR. Our findings provide valuable insight into the biological functions of oxidized phospholipids, advancing our understanding of their roles in cellular processes.

    DOI： 10.1016/j.bbrc.2025.151858

    Web of Science

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  • Oxidized-LDL Induces Metabolic Dysfunction in Retinal Pigment Epithelial Cells Reviewed

    Tomomatsu Manami, Imamura Naoto, Izumi Hoshimi, Watanabe Masatsugu, Ikeda Masataka, Ide Tomomi, Uchinomiya Shohei, Ojida Akio, Jutanom Mirinthorn, Morimoto Kazushi, Yamada Ken-ichi

    Biological and Pharmaceutical Bulletin   47 ( 3 )   641 - 651   2024.3   （ ISSN:09186158 eISSN:13475215 ）

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Pharmaceutical Society of Japan  

    <p>Recently, mitochondrial dysfunction has gained attention as a causative factor in the pathogenesis and progression of age-related macular degeneration (AMD). Mitochondrial damage plays a key role in metabolism and disrupts the balance of intracellular metabolic pathways, such as oxidative phosphorylation (OXPHOS) and glycolysis. In this study, we focused on oxidized low-density lipoprotein (ox-LDL), a major constituent of drusen that accumulates in the retina of patients with AMD, and investigated whether it could be a causative factor for metabolic alterations in retinal pigment epithelial (RPE) cells. We found that prolonged exposure to ox-LDL induced changes in fatty acid β-oxidation (FAO), OXPHOS, and glycolytic activity and increased the mitochondrial reactive oxygen species production in RPE cells. Notably, the effects on metabolic alterations varied with the concentration and duration of ox-LDL treatment. In addition, we addressed the limitations of using ARPE-19 cells for retinal disease research by highlighting their lower barrier function and FAO activity compared to those of induced pluripotent stem cell-derived RPE cells. Our findings can aid in the elucidation of mechanisms underlying the metabolic alterations in AMD.</p>

    DOI： 10.1248/bpb.b23-00849

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    CiNii Research

  • Oxidized-LDL induces metabolic dysfunction in retinal pigment epithelial cells. Invited Reviewed International journal

    Tomomatsu M, Imamura N, Izumi H, Watanabe M, Ikeda M, Ide T, Uchinomiya S, Ojida A, Jutanom M, Morimoto K, Yamada KI

    2024.3

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    Language：English   Publishing type：Research paper (scientific journal)  

  • LC-MS/MS analysis of milk triacylglycerol hydroperoxide isomers which are generated corresponding to the photo- and thermal-oxidation. Invited Reviewed International journal

    Saito H, Kato S, Shimizu N, Takahashi T, Jutanom M, Ito J, Kasatani S, Nakagawa K.

    2024.3

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    Language：English   Publishing type：Research paper (scientific journal)  

  • 酸化LDLは網膜色素上皮細胞の代謝不全を誘導する(Oxidized-LDL Induces Metabolic Dysfunction in Retinal Pigment Epithelial Cells)

    Tomomatsu Manami, Imamura Naoto, Izumi Hoshimi, Watanabe Masatsugu, Ikeda Masataka, Ide Tomomi, Uchinomiya Shohei, Ojida Akio, Jutanom Mirinthorn, Morimoto Kazushi, Yamada Ken-ichi

    Biological & Pharmaceutical Bulletin   47 ( 3 )   641 - 651   2024.3   （ ISSN:0918-6158 ）

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    Language：English   Publisher：(公社)日本薬学会  

    加齢黄斑変性患者の網膜に蓄積するドルーゼンの主要成分である酸化LDL(oxLDL)に着目し、oxLDLが網膜色素上皮(RPE)細胞の代謝に及ぼす影響について検討した。ox-LDLへの長時間曝露はRPE細胞の脂肪酸β酸化(FAO)、酸化的リン酸化および解糖活性を変化させ、ミトコンドリアの活性酸素種産生を増加させた。代謝に対する影響は、ox-LDL処理の濃度および時間により変化した。多能性幹細胞由来RPE細胞と比べてARPE-19細胞のバリア機能およびFAO活性は低く、網膜疾患の研究にARPE-19細胞を用いることの限界が示された。

  • LC-MS/MS analysis of milk triacylglycerol hydroperoxide isomers which are generated corresponding to the photo- and thermal-oxidation Reviewed

    Saito, H; Kato, S; Shimizu, N; Takahashi, T; Jutanom, M; Ito, J; Kasatani, S; Nakagawa, K

    FOOD RESEARCH INTERNATIONAL   178   113913   2024.2   （ ISSN:0963-9969 eISSN:1873-7145 ）

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Food Research International  

    Milk is a rich source of essential nutrients such as lipids. However, lipid oxidation can be considered a crucial factor in determining the initial stage of milk deterioration. Therefore, it is essential to identify the mechanisms of lipid oxidation, such as photo-oxidation or thermal oxidation, to efficiently prevent it by selecting proper antioxidants. In this study, the oxidation mechanisms of long-life (LL) milk were investigated, and triacylglycerol hydroperoxide isomers generated corresponding to the oxidation mechanisms were analyzed by LC-MS/MS. This study first prepared the standard of TG 4:0_16:0_18:1;OOH isomers, which are the appropriate target for evaluating LL milk's oxidation mechanism. The authentic standards provided the robust analysis of TG 4:0_16:0_18:1;OOH isomers and suggested that LL milk was susceptible to photo-oxidation rather than thermal-oxidation. Furthermore, it was discovered that radicals play a role in the oxidation of LL milk during photo-oxidation. This information could be valuable in effectively preventing photo-oxidation in LL milk. It is important to note that milk is contained in a variety of food products. Hence, these findings would be applicable not only to milk but also to various milk-containing food products.

    DOI： 10.1016/j.foodres.2023.113913

    Web of Science

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  • Analysis of oxidized glucosylceramide and its effects on altering gene expressions of inflammation induced by LPS in intestinal tract cell models. Invited Reviewed International journal

    Jutanom M, Kato S, Yamashita S, Toda M, Kinoshita M, Nakagawa K.

    2023.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • The difference in the cellular uptake of tocopherol and tocotrienol is influenced by their affinities to albumin Invited Reviewed International journal

    Takashi Nakatomi, Mayuko Itaya‑Takahashi, Yosuke Horikoshi, Naoki Shimizu, Isabella Supardi Parida, Mirinthorn Jutanom, Takahiro Eitsuka, Yoshikazu Tanaka, Jean‑Marc Zingg, Tatsuya Matsura, Kiyotaka Nakagawa

    2023.4

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Clinical Evaluation Based on a New Approach to Improve the Accuracy of 4β-Hydroxycholesterol Measurement as a Biomarker of CYP3A4 Activity. Invited Reviewed International journal

    Taya Y, Mizunaga M, Nakao S, Jutanom M, Shimizu N, Nomura Y, Nakagawa K.

    2023.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Structural Analysis and Anti-Inflammatory Effect of a Digalactosyldiacylglycerol-Monoestolide, a Characteristic Glycolipid in Oats. Invited Reviewed International journal

    Hiroki Yamada, Junya Ito, Naoki Shimizu, Takumi Takahashi, Chikara Kato, Isabella Supardi Parida, Mirinthorn Jutanom, Katsuyuki Ishihara, Kiyotaka Nakagawa

    2022.6

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Effects of sphingolipid fractions from golden oyster mushroom (Pleurotus citrinopileatus) on apoptosis induced by inflammatory stress in an intestinal tract in vitro model. Invited Reviewed International journal

    Mirinthorn Jutanom, Chisato Higaki, Shinji Yamashita, Kiyotaka Nakagawa, Satoshi Matsumoto, Mikio Kinoshita

    2020.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Polar lipid fraction from golden oyster mushrooms (Pleurotus citrinopileatus) suppresses colon injuries from inflammatory stresses in vivo and in vitro. Invited Reviewed International journal

    Shinji Yamashita, Takuya Seino, Miho Inobe, Mirinthorn Jutanom, Satoshi Matsumoto, Mikio Kinoshita

    2020.3

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    Language：English   Publishing type：Research paper (scientific journal)  

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Presentations

  • Exploring novel oxidized phospholipids to elucidate an exhaustive understanding of their functions.

    Mirinthorn JUTANOM

    The 9th JAPAN-TAIWAN Joint Symposium  2024.9 

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    Event date： 2024.9

    Presentation type：Oral presentation (general)  

    Venue：長崎   Country：Japan  

  • Elucidation of head-modified phospholipids functions

    大田 友輝, Jutanom Mirinthorn, 廣保 郁, 上野 亮哉, 小櫻 英翔, 山田 健一

    The 9th JAPAN-TAIWAN Joint Symposium  2024.9 

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    Event date： 2024.9

    Presentation type：Oral presentation (general)  

    Country：Japan  

  • 血管性認知症における脂質過酸化反応を起点とした慢性炎症

    萩森 諒, 阿部 真紗美, 上野 亮哉, Jutanom Mirinthorn, 森本 和志, 山田 健一

    次世代を担う若手のためのフィジカル・ファーマフォーラム2024  2024.8 

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    Event date： 2024.8

    Presentation type：Oral presentation (general)  

    Venue：神奈川   Country：Japan  

  • 求電子性酸化脂質を捕捉する蛍光プローブの開発

    川野 蒼太, 田添 果歩, 松岡 悠太, 高橋 政友, 和泉 自泰, 馬場 健史, 森本 和志, Jutanom Mirinthorn, 山田 健一

    次世代を担う若手のためのフィジカル・ファーマフォーラム2024  2024.8 

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    Event date： 2024.8

    Presentation type：Oral presentation (general)  

    Venue：神奈川   Country：Japan  

  • Exploring novel oxidized phospholipids to elucidate an exhaustive understanding of their functions

    Mirinthorn JUTANOM

    第50回日本毒性学会学術集会  2024.7 

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    Event date： 2024.7

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • ox-LDLはヒト網膜色素上皮細胞の代謝変容を誘導する

    友松 愛美、今村 直人、和泉 星余、池田 昌隆、井手 友美、内之宮 祥平、王子田 彰夫、Jutanom Mirinthorn、森本 和志、山田 健一

    日本薬学会第144年会  2024.3 

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    Event date： 2024.3

    Presentation type：Poster presentation  

    Venue：神奈川   Country：Japan  

  • LC/MS/MS解析による炎症反応を惹起する新規生理活性酸化リン脂質の同定

    上野亮哉、岩尾彬広、小櫻英翔、高橋政友、和泉自泰、馬場健史、加藤俊治、仲川清隆、松岡悠太、Jutanom Mirinthorn、森本和志、山田健一

    日本薬学会第144年会  2024.3 

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    Event date： 2024.3

    Presentation type：Poster presentation  

    Venue：神奈川   Country：Japan  

  • 血管性認知症モデルマウスにおける脂質過酸化反応阻害剤の炎症抑制効果

    萩森 諒、阿部 真紗美、Jutanom Mirinthorn、森本 和志、山田 健一

    日本薬学会第144年会  2024.3 

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    Event date： 2024.3

    Presentation type：Poster presentation  

    Venue：神奈川   Country：Japan  

  • 機能性ニトロキシドプローブを用いた微量脂質ラジカル付加体精製法の開発と応用

    田中萌、齋藤耕太、松岡悠太、高橋政友、和泉自泰、馬場健史、Jutanom Mirinthorn、森本和志、山田健一

    第40回日本薬学会九州山口支部大会   2023.11 

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    Event date： 2023.11

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • オキシリピドミクス解析を用いたミクログリアの炎症応答を制御する新規酸化リン脂質の同定

    上野亮哉、岩尾彬広、小櫻英翔、高橋政友、和泉自泰、馬場健史、加藤俊治、仲川清隆、松岡悠太、Mirinthorn Jutanom、森本和志、山田健一

    第40回日本薬学会九州山口支部大会   2023.11 

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    Event date： 2023.11

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • ヒト網膜色素上皮細胞の代謝変容に対するox-LDLの作用　

    友松愛美、今村直人、和泉星余、池田昌隆、井手友美、内之宮祥平、王子田彰夫、Mirinthorn Jutanom、森本和志、山田健一

    第40回日本薬学会九州山口支部大会   2023.11 

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    Event date： 2023.11

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • フェロトーシス耐性に対するAKR1Cの関与　

    吉田汐里、森本和志、松岡悠太、Jutanom Mirinthorn、山田健一

    第40回日本薬学会九州山口支部大会   2023.11 

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    Event date： 2023.11

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 蛍光プローブを用いたチオール基反応性求電子性酸化脂質の探索

    田添佳歩、松岡悠太、高橋政友、和泉自泰、馬場健史、 森本和志、Jutanom Mirinthorn、山田健一

    第40回日本薬学会九州山口支部大会   2023.11 

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    Event date： 2023.11

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • フェロトーシスを特徴づける酸化リン脂質の探索

    陣内優佳、中英人、伊藤綾人、Jutanom Mirinthorn、森本和志、松岡悠太、山田健一

    第96回日本生化学会  2023.11 

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    Event date： 2023.10 - 2023.11

    Presentation type：Poster presentation  

    Venue：福岡   Country：Japan  

  • 炎症反応を制御する酸化リン脂質の探索

    上野亮哉、岩尾彬広、小櫻英翔、高橋政友、和泉自泰、馬場健史、加藤俊治、仲川清隆、松岡悠太、Mirinthorn Jutanom、森本和志、山田健一

    第96回日本生化学会  2023.11 

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    Event date： 2023.10 - 2023.11

    Presentation type：Poster presentation  

    Venue：福岡   Country：Japan  

  • 脂質過酸化反応抑制剤の探索と慢性脳低灌流モデルマウスへの適用

    阿部 真紗美、宗 茉里恵、進藤 早紀、松岡 悠太、Mirinthorn Jutanom、 森本 和志、山田 健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

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    Event date： 2023.10

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 網膜色素上皮細胞で生じる代謝変動に対するox-LDL の作用解明

    友松愛美、今村直人、和泉星余、池田昌隆、井手友美、内之宮祥平、王子田彰夫、Mirinthorn Jutanom、森本和志、山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

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    Event date： 2023.10

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 求電子性酸化脂質を捕捉する蛍光プローブの開発

    田添佳歩、松岡悠太、高橋政友、和泉自泰、馬場健史、森本和志、 Jutanom Mirinthorn、山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

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    Event date： 2023.10

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 炎症反応を制御する酸化リン脂質の探索

    上野亮哉、岩尾彬広、松岡悠太、高橋政友、和泉自泰、馬場健史、加藤俊治、仲川清隆、Mirinthorn Jutanom、森本和志、山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

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    Event date： 2023.10

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • Exploring novel oxidized phospholipids to elucidate an exhaustive understanding of their functions Invited

    Mirinthorn Jutanom

    第51回日本毒性学会学術年会  2024.7 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Exploring novel oxidized phospholipids to elucidate an exhaustive understanding of their functions Invited International conference

    Mirinthorn Jutanom

    THE 9TH JAPAN-TAIWAN JOINT SYMPOSIUM FOR PHARMACEUTICAL SCIENCES  2024.9 

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    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 脂質過酸化反応を起点とした血管性認知症の病態機序解明

    萩森 諒, 阿部 真紗美, Jutanom Mirinthorn, 森本 和志, 山田 健一

    日本生化学会大会プログラム・講演要旨集  2024.11  (公社)日本生化学会

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    Language：Japanese  

  • 短寿命活性種の毒性と機能性　酸化リン脂質の新たな機能解明に向けた研究(Exploring novel oxidized phospholipids to elucidate an exhaustive understanding of their functions)

    Jutanom Mirinthorn, Yamada Ken-ichi

    The Journal of Toxicological Sciences  2024.7  (一社)日本毒性学会

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    Language：English   Presentation type：Oral presentation (general)  

  • Exploring novel oxidized phospholipids to elucidate an exhaustive understanding of their functions

    JUTANOM Mirinthorn, YAMADA Ken-Ichi

    Annual Meeting of the Japanese Society of Toxicology  2024  The Japanese Society of Toxicology

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    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    <p>Lipid peroxidation generates numerous oxidized lipids and has shown its essential role in cell biology and human health, in which oxidized phospholipids (OxPLs) are the crucial lipids reportedly involved in the pathogenesis and progression of numerous diseases. Although OxPLs are known to modulate various biological functions, their precise role remains an ongoing debate due to the lack of structural information and dedicated analytical methods. In this study, we used mass spectrometry and HPLC techniques to explore and isolate novel types of OxPLs, such as oxygenated and truncated acyl chains of phospholipids, and then purifying by preparative HPLC. <b>It has been found that the production of oxidized lipids varies based on the oxidation methods. Additionally, we discovered that novel OxPLs identified in this study indicate multiple activities relating to inflammation and cell signaling.</b> The modification of phospholipids by oxidation is one of the critical determinants of its interactions with other molecules, proteins, and the lipid bilayer, influencing membrane properties and activities. <b>Developing the OxPLs library using mass spectrometry and OxPLs purifying are expected to provide a comprehensive understanding of OxPLs involved in diseases and pave the way for proposing candidate compounds for innovative therapeutic strategies in lipid peroxidation-related diseases.</b></p>

    DOI： 10.14869/toxpt.51.1.0_s31-3

    CiNii Research

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Professional Memberships

  • 日本毒性学会学術年会

    2024 - Present

  • 日本薬学会会員

    2023 - Present

  • The Pharmaceutical Society of Japan

  • The Japanese conference on the biochemistry of lipids

  • Japanese Society Toxicology

Research Projects

  • Investigation of the functions of Phosphatidylethanolamine head modifications in lipid peroxidation and diseases

Class subject

  • Lipid peroxidation and diseases in Expert english (専門英語, 2nd year)

    2024.12   Second semester

  • 先端研究実験II

    2024.4 - 2024.9   First semester

  • 専門英語

    2023.10 - 2024.3   Second semester

  • 先端研究実験II

    2023.4 - 2023.9   First semester

FD Participation

  • 2025.9   Role：Participation   Title：University's FD (Drug abuse prevention)

    Organizer：University-wide

  • 2024.7   Role：Participation   Title：産学連携を通じた大学発ベンチャーとイノベーションの創出

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.8   Role：Participation   Title：令和５年度４部局合同男女共同参画ＦＤ

    Organizer：[Undergraduate school/graduate school/graduate faculty]

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  Mahidol University  Domestic/International Classification:Overseas 

    Semester, Day Time or Duration：29 May 204

Participation in international educational events, etc.

  • 2024.4

    Tohoku University

    G-Rexs 2024

Teaching Student Awards

  • 学生優秀ポスター賞銅賞

    Year and month of award：2024.6

    Classification of award-winning students：Postgraduate student   Name of award-winning student：萩森　諒

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    血管性認知症モデルマウスに対する脂質過酸化反応抑制剤の病態保護効果

  • 学生優秀ポスター賞金賞

    Year and month of award：2024.6

    Classification of award-winning students：Postgraduate student   Name of award-winning student：上野　亮哉

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    LC/MS/MS解析による炎症反応を惹起する新規生理活性酸化リン脂質の同定

  • 学生優秀ポスター賞銅賞

    Year and month of award：2024.6

    Classification of award-winning students：Doctoral student   Name of award-winning student：友松　愛美

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    ox-LDLはヒト網膜色素上皮細胞のエネルギー代謝を変容させる

Other educational activity and Special note

  • 2025  Lecture at Education Method and Practice  Pharmaceutical science training

Outline of Social Contribution and International Cooperation activities

  • Supported international collaboration with Mahidol University through diverse research initiatives, including inviting distinguished lecturers and jointly conducting cutting-edge studies on lipid peroxidation and its impact on various diseases. These efforts foster cross-cultural academic exchange and advance scientific understanding in this important field.

Acceptance of Foreign Researchers, etc.

  • Acceptance period： 2024.6 - 2024.9   （Period）：1 month or more

    Nationality：Thailand

  • Acceptance period： 2024.3 - 2024.4   （Period）：1 month or more

    Nationality：Malaysia

  • Acceptance period： 2023.6 - 2023.9   （Period）：1 month or more

    Nationality：Thailand

  • Acceptance period： - 2023.9   （Period）：1 month or more

    Nationality：Thailand