Updated on 2024/09/03

Information

 

写真a

 
WAKABAYASHI RIE
 
Organization
Faculty of Engineering Department of Applied Chemistry Associate Professor
School of Engineering (Joint Appointment)
Graduate School of Engineering (Joint Appointment)
Title
Associate Professor
Profile
工学研究院、工学部の准教授として、教育および研究、その他全般の学生の指導、研究室運営に携わっている。 【教育】 大学院教育2科目、学士教育2科目の講義および講義補助業務を行っている。学部学生、大学院学生の研究指導を行っている。 【研究】 主に、バイオマテリアル応用へ向けたペプチド自己集合体に関する研究、新規タンパク質-ポリマーハイブリッド材料の開発に関する研究、生体分子の油状ナノ分散化技術を利用した低侵襲性経皮ワクチンの創製に関する研究に従事している。 【運営】 • 研究室内の安全衛生委員としての業務を行っている(試薬・有機溶媒等の発注業務・安全管理、実験環境の管理、職場巡視等)。 • 研究室内の実験装置、備品等の管理を行っている。 • 研究室の運営補助を行っている(各種セミナー、行事等のスケジュール管理等)。 • センター試験の監督、個別学力検査の監督補助を行う。 • 研究室のセミナーあるいは日々の研究室生活において、研究活動や安全面、生活面での指導、支援を行う。

Degree

  • PhD

Research History

  • Kyushu University Faculty of Engineering Associate Professor

    2023.1 - Present

      More details

  • Kyushu University Faculty of Engineering Assistant Professor

    2012.4 - 2022.12

      More details

Research Interests・Research Keywords

  • Research theme:Development of scaffolds to assemble proteins

    Keyword:proteins, enzymatic reaction, scaffold

    Research period: 2012.4 - 2024.3

  • Research theme:Peptide Self-Assembled Nanomaterials for Biological Applications

    Keyword:peptide, self-assembly, biomaterials

    Research period: 2012.4 - 2024.3

  • Research theme:Development of transcutaneous vaccine by biomolecular delivery through the skin

    Keyword:protein, peptide, transcutaneous delivery, vaccine

    Research period: 2012.4 - 2024.3

Awards

  • 第13回資生堂女性研究者サイエンスグラント

    2020.7   資生堂  

     More details

    高機能エマルション製剤の創製に向けた自己組織化ペプチドの活用

  • 第8回女性化学者奨励賞

    2020.3   日本化学会  

  • 平成30年度九州大学若手女性研究者・女子大学院生優秀研究者賞 若手女性研究者部門 優秀賞

    2018.9   九州大学  

     More details

    「ペプチド、タンパク質を構成要素とした機能性材料の開発と応用」に関し、過去3年間の研究業績を認められ受賞した。

  • 第4回新化学技術研究奨励賞

    2015.5   公益社団法人新化学技術推進協会  

     More details

    機能性生体分子の酵素触媒的修飾を可能とする自己集合足場のナノデザイン

  • 第54回学術奨励賞

    2014.4   宇部興産学術振興財団  

     More details

    生体触媒による分子集合体の階層制御

Papers

  • Supramolecular localization in liquid-liquid phase separation and protein recruitment in confined droplets

    Hiroki Obayashi, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Chemical Communications   59 ( 4 )   414 - 417   2022.12   ISSN:1359-7345 eISSN:1364-548X

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    This study investigated the localization of artificial peptide supramolecular fibers in liquid-liquid phase separation (LLPS). Hierarchical organization led to the localization of supramolecules in LLPS droplets. Moreover, proteins were recruited into confined droplets by the physical adsorption of proteins on the supramolecules, enabling an enhanced cascade reaction.

    DOI: 10.1039/d2cc05910j

    Web of Science

    Scopus

    PubMed

    researchmap

  • Hydrophobic immiscibility controls self-sorting or co-assembly of peptide amphiphiles

    Rie Wakabayashi, Rino Imatani, Mutsuhiro Katsuya, Yuji Higuchi, Hiroshi Noguchi, Noriho Kamiya, Masahiro Goto

    Chemical Communications   58 ( 4 )   585 - 588   2022.1   ISSN:1359-7345 eISSN:1364-548X

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    Pairs of peptide amphiphiles with immiscible hydrophobic tails were synthesized and their assembly formation was investigated. These pairs formed self-sorting supramolecular fibres using a standard heating–cooling protocol, while one pair with longer hydrophobic tails formed a co-assembly when an additional heating process was applied.

    DOI: 10.1039/d1cc05560g

    Web of Science

    Scopus

    PubMed

    researchmap

  • pH-Responsive Self-Assembly of Designer Aromatic Peptide Amphiphiles and Enzymatic Post-Modification of Assembled Structures Reviewed International journal

    Rie Wakabayashi, Ayato Higuchi, Hiroki Obayashi, Masahiro Goto, Noriho Kamiya

    International Journal of Molecular Sciences   22 ( 7 )   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms22073459

  • Complementary interaction with peptide amphiphiles guides size-controlled assembly of small molecules for intracellular delivery Reviewed International journal

    Rie Wakabayashi, Hiroki Obayashi, Ryuichiro Hashimoto, Noriho Kamiya, Masahiro Goto

    Chemical Communications   55 ( 49 )   6997 - 7000   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c9cc02473e

  • Transcutaneous codelivery of tumor antigen and resiquimod in solid-in-oil nanodispersions promotes antitumor immunity Reviewed International journal

    Rie Wakabayashi, Hidetoshi Kono, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    ACS Biomaterials Science and Engineering   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsbiomaterials.9b00260

  • Designer aromatic peptide amphiphiles for self-assembly and enzymatic display of proteins with morphology control Reviewed International journal

    Rie Wakabayashi, Ayumi Suehiro, Masahiro Goto, Noriho Kamiya

    Chemical Communications   55 ( 5 )   640 - 643   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C8CC08163H

  • Solid-in-Oil Peptide Nanocarriers for Transcutaneous Cancer Vaccine Delivery against Melanoma Reviewed International journal

    Rie Wakabayashi, Masato Sakuragi, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    Mol. Pharm.   15 ( 3 )   955 - 961   2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.7b00894

  • Protein-grafted polymers prepared through a site-specific conjugation by microbial transglutaminase for an immunosorbent assay Reviewed International journal

    Rie Wakabayashi, Kensuke Yahiro, Kounosuke Hayashi, Masahiro Goto, Noriho Kamiya

    Biomacromolecules   18   422 - 430   2017.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Transcutaneous immunization against cancer using solid-in-oil nanodispersions Reviewed International journal

    Yuya Hirakawa, Rie Wakabayashi, Ayaka Naritomi, Masato Sakuragi, Noriho Kamiya, Masahiro Goto

    Medicinal Chemical Communications   6   1387 - 1392   2015.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • The Self-Assembly and Secondary Structure of Peptide Amphiphiles Determine the Membrane Permeation Activity Reviewed International journal

    Rie Wakabayashi, Yuko Abe, Noriho Kamiya, Masahiro Goto

    The Royal Society of Chemistry   4   30654 - 30657   2014.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • A Novel Surface-Coated Nanocarrier for Efficient Encapsulation and Delivery of Camptothecin to Cells Reviewed International journal

    Rie Wakabayashi, Ryutaro Ishiyama, Noriho Kamiya, Masahiro Goto

    Medicinal Chemical Communications   5   1515 - 1519   2014.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Sustainable Synthesis of Cellulose Nanofibers from Industrial Agar Seaweed Waste Biomass Using Hydrated Deep Eutectic Solvents

    Hardiningtyas, SD; Putra, BU; Anggara, KB; Yuniasani, I; Ramadhan, W; Pari, RF; Uju; Hastuti, N; Indrawan, DA; Wakabayashi, R; Goto, M; Kamiya, N

    WASTE AND BIOMASS VALORIZATION   15 ( 8 )   4899 - 4913   2024.8   ISSN:1877-2641 eISSN:1877-265X

     More details

    Publisher:Waste and Biomass Valorization  

    Purpose: This work evaluated the profiles of Industrial agar seaweed waste biomass (ISWB) and pretreated ISWB by using deep eutectic solvent (DESs) and NaOH. The profiles of nanocellulose obtained from pretreated ISWB (with various types of hydrogen bond donors of choline chloride (ChCl)-based hydrated DES) were also evaluated. Methods: ISWB underwent pre-treatment with either 100% wt. DES (1:1 molar ratio of ethylene glycol: citric acid) or 10% wt. NaOH at 80 °C to 90 °C. Subsequent treatment involved 10% wt. DES or ChCl-based hydrated DES with various HBDs (oxalic acid, citric acid, and urea) in a 1:2 molar ratio to produce nanocellulose. Results: Cellulose nanofibers isolated by the CE-DES approach exhibited a substantially higher yield compared with those obtained via the CE-NaOH method. CE-DES method induced swelling of ISWB and facilitate production of cellulose nanofibers. SEM images of samples indicates the presence of fibrous nanostructures across the majority of the specimens. Fourier-transform infrared (FTIR) spectroscopy demonstrated uniformity among all samples; they exhibited a consistent fingerprint pattern. X-ray diffraction (XRD) spectra indicated the presence of cellulose Type I in cellulose nanofibers produced by CE–DES, but not definitively in nanocellulose produced by the CE–NaOH method. Conclusion: Cellulose nanofibers can be isolated from ISWB by using various DES and exhibits substantial characteristics of cellulose nanofibers from different ISWB pretreatment protocols. Graphical Abstract: (Figure presented.)

    DOI: 10.1007/s12649-024-02499-z

    Web of Science

    Scopus

  • Design and validation of functionalized redox-responsive hydrogel beads for high-throughput screening of antibody-secreting mammalian cells

    Wulandari, DA; Tsuru, K; Minamihata, K; Wakabayashi, R; Egami, G; Kawabe, Y; Kamihira, M; Goto, M; Kamiya, N

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   138 ( 1 )   89 - 95   2024.7   ISSN:1389-1723 eISSN:1347-4421

     More details

    Language:English   Publisher:Journal of Bioscience and Bioengineering  

    Antibody drugs play a vital role in diagnostics and therapy. However, producing antibodies from mammalian cells is challenging owing to cellular heterogeneity, which can be addressed by applying droplet-based microfluidic platforms for high-throughput screening (HTS). Here, we designed an integrated system based on disulfide-bonded redox-responsive hydrogel beads (redox-HBs), which were prepared through enzymatic hydrogelation, to compartmentalize, screen, select, retrieve, and recover selected Chinese hamster ovary (CHO) cells secreting high levels of antibodies. Moreover, redox-HBs were functionalized with protein G as an antibody-binding module to capture antibodies secreted from encapsulated cells. As proof-of-concept, cells co-producing immunoglobulin G (IgG) as the antibody and green fluorescent protein (GFP) as the reporter molecule, denoted as CHO(IgG/GFP), were encapsulated into functionalized redox-HBs. Additionally, antibody-secreting cells were labeled with protein L-conjugated horseradish peroxidase using a tyramide amplification system, enabling fluorescence staining of the antibody captured inside the beads. Redox-HBs were then applied to fluorescence-activated droplet sorting, and selected redox-HBs were degraded by reducing the disulfide bonds to recover the target cells. The results indicated the potential of the developed HTS platform for selecting a single cell viable for biopharmaceutical production.

    DOI: 10.1016/j.jbiosc.2024.04.001

    Web of Science

    Scopus

    PubMed

  • Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens

    Islam, R; Nabila, FH; Wakabayashi, R; Kawaguchi, Y; Kamiya, N; Moniruzzaman, M; Goto, M

    MOLECULES   29 ( 13 )   2024.7   eISSN:1420-3049

     More details

    Language:English   Publisher:Molecules  

    Herein, we report a transdermal patch prepared using an ionic liquid-based solid in oil (IL-S/O) nanodispersion and a pressure-sensitive adhesive (PSA) to deliver the macromolecular antigenic protein, ovalbumin (OVA). The IL-S/O nanodispersion and a PSA were first mixed at an equal weight ratio, then coated onto a release liner, and covered with a support film. To evaluate the effect of the PSA, three types of PSAs, DURO-TAK 87-4098, DURO-TAK 87-4287, and DURO-TAK 87-235A, were used to obtain the corresponding IL-S/O patches SP-4098, SP-4287, and SP-235A, respectively. The prepared IL-S/O patches were characterized for surface morphology, viscoelasticity, and moisture content. In vitro skin penetration and in vivo immunization studies of the IL-S/O patches were performed using Yucatan micropig skin and the C57BL/6NJc1 mice model, respectively. The SP-4098 and SP-4287 delivered 5.49-fold and 5.47-fold higher amounts of drug compared with the aqueous formulation. Although both patches delivered a similar amount of drug, SP-4287 was not detached fully from the release liner after 30 days, indicating low stability. Mice immunized with the OVA-containing SP-4098 produced a 10-fold increase in anti-OVA IgG compared with those treated with an aqueous formulation. These findings suggested that the IL-S/O patch may be a good platform for the transdermal delivery of antigen molecules.

    DOI: 10.3390/molecules29132995

    Web of Science

    Scopus

    PubMed

  • Prospecting <i>Ulva lactuca</i> seaweed in Java Island, Indonesia, as a candidate resource for industrial applications

    Pari, RF; Uju; Wijayanta, AT; Ramadhan, W; Hardiningtyas, SD; Kurnia, KA; Firmansyah, ML; Hana, A; Abrar, MN; Wakabayashi, R; Kamiya, N; Goto, M

    FISHERIES SCIENCE   2024.6   ISSN:0919-9268 eISSN:1444-2906

     More details

    Publisher:Fisheries Science  

    Ulva is an unutilized green seaweed that grows in the intertidal zone around the coast of Java Island, Indonesia. In this study, U. lactuca samples collected from three regions in south of Java Island (Cihara, Surade, and Tepus) were studied in terms of their chemical composition, physical properties and its bioactivity, to determine the best regions for establishing seaweed industries. The chemical characteristics differed significantly among different regions, where the seaweed from Tepus, Surade and Cihara had the highest content of protein (22.93%), carbohydrate (61.58%), and mineral (28.72%), respectively. The amino acids were dominated with L-aspartic acid and L-glutamic acid. All U. lactuca samples contained abundant pigments, such as chlorophylls and carotenoids, especially samples from Tepus. The highest content of crude ulvan was found in Surade seaweed (26.9%). Chemical and physical analyses showed the presence of S = O and C–O–S functional groups in ulvan, a sulfated polysaccharide unique to Ulva sp., with thermal degradation up to 220 °C. Crude ulvan from Surade and Tepus seaweed exhibited bioactivity to support proliferation of fibroblast cells at 100 and 1000 ppm, respectively. Based on the properties of U. lactuca, Tepus and Surade were identified as potential sites to establish aquaculture and/or processing industries.

    DOI: 10.1007/s12562-024-01799-6

    Web of Science

    Scopus

  • Facilitating Ulvan Extraction from Ulva lactuca via Deep Eutectic Solvent and Peracetic Acid Treatment

    Ramadhan W., Alamsyah A.D., Uju , Hardiningtyas S.D., Pari R.F., Wakabayashi R., Kamiya N., Goto M.

    ASEAN Journal of Chemical Engineering   24 ( 1 )   90 - 101   2024.4   ISSN:16554418

     More details

    Publisher:ASEAN Journal of Chemical Engineering  

    Ulva lactuca is a green seaweed commonly called sea lettuce and contains sulphated polysaccharides that have biological activity. Despite its lack of ecological sustainability, strong acids (HCl) and strong bases (NaOH) are widely used as solvents in the conventional extraction process for ulvan. Deep eutectic solvent (DES) is an alternative to ulvan extraction solvent, which is more environmentally friendly and has low toxicity. This study aims to assess the efficacy of peracetic acid (PAA) pretreatment and post-treatment in enhancing the quality of extracted ulvan using a DES-based solvent in the extraction process. Ulvan extraction using DES with a temperature of 85-95°C for 1 hour and adding 2% PAA pretreatment, 0.1%, 0.5%, and 2% PAA post-treatment were conducted. PAA pre-and post-treatment was carried out with a 1:10 (w/v) ratio at room temperature for 30 minutes. The analysis included moisture content, yield, functional groups, sulphate content, and color. The test results revealed that ulvan treated with 2% PAA pretreatment had the highest moisture content and sulphate content, at 18.71% and 33.39%, respectively, while ulvan treated with 0.1% PAA post-treatment had the highest yield, at 41.96%. Adding peracetic acid concentration can increase the color quality of the ulvan. PAA pre-and post-treatment had a significant effect on all ulvan quality parameters.

    DOI: 10.22146/ajche.12272

    Scopus

  • Design of Protease-Responsive Antifungal Liposomal Formulation Decorated with a Lipid-Modified Chitin-Binding Domain

    Saputra, H; Safaat, M; Santoso, P; Wakabayashi, R; Goto, M; Taira, T; Kamiya, N

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   25 ( 7 )   2024.4   ISSN:1661-6596 eISSN:1422-0067

     More details

    Language:English   Publisher:International Journal of Molecular Sciences  

    Candida albicans is a prevalent fungal pathogen that displays antibiotic resistance. The polyene antifungal amphotericin B (AmB) has been the gold standard because of its broad antifungal spectra, and its liposomal formulation, AmBisome, has been used widely and clinically in treating fungal infections. Herein, we explored enhancing the antifungal activity of AmBisome by integrating a small chitin-binding domain (LysM) of chitinase A derived from Pteris ryukyuensis. LysM conjugated with a lipid (LysM–lipid) was initially prepared through microbial transglutaminase (MTG)-mediated peptide tag-specific conjugation of LysM with a lipid–peptide substrate. The AmBisome formulation modified with LysM–lipid conjugates had a size distribution that was comparable to the native liposomes but an increased zeta potential, indicating that LysM–lipid conjugates were anchored to AmBisome. LysM–lipid-modified AmBisome exhibited long-term stability at 4 °C while retaining the capacity to bind chitin. Nevertheless, the antifungal efficacy of LysM–lipid-modified AmBisome against C. albicans was modest. We then redesigned a new LysM–lipid conjugate by introducing a peptide linker containing a thrombin digestion (TD) site at the C-terminus of LysM (LysM–TD linker–lipid), thereby facilitating the liberation of the LysM domain from AmBisome upon the addition of thrombin. This new AmBisome formulation anchored with LysM–TD linker–lipid exhibited superior performance in suppressing C. albicans growth in the presence of thrombin compared with the LysM–lipid formulation. These results provide a platform to design stimuli-responsive AmBisome formulations that respond to external environments and thus advance the treatment of pathogenic fungi infections.

    DOI: 10.3390/ijms25073567

    Web of Science

    Scopus

    PubMed

  • Ionic liquid-mediated ethosome for transdermal delivery of insulin. International journal

    Fahmida Habib Nabila, Rashedul Islam, Islam Md Shimul, Muhammad Moniruzzaman, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Chemical communications (Cambridge, England)   2024.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d3cc06130b

  • Ionic Liquid-Based patch formulation for enhanced transdermal delivery of sparingly soluble drug

    Rashedul Islam, Fahmida Habib Nabila, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   397   2024.3   ISSN:0167-7322 eISSN:1873-3166

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    Ionic liquid (IL)-based transdermal formulations have gained significant attention because of their high skin penetration efficiency and ease of design. However, many IL-based formulations exhibit low viscosity, which hinders direct administration and leads to less efficient drug delivery. Therefore, there is a pressing need for specialized formulations with improved viscosity and efficacy as a drug delivery platform. In this study, we report a ready-to-use transdermal patch system utilizing IL-in-oil (IL/O) microemulsions to deliver acyclovir, a sparingly soluble antiviral drug. To prepare the patch system, a mixture containing equal weights of IL/O microemulsions and adhesive (Durotak 87–4098) was homogenized, subsequently coated on a liner, and covered by a support film. These patches were produced with varying thicknesses (100 μm, 200 μm, 300 μm, and 500 μm) via a solvent evaporation technique. A 24-hour in vitro skin permeation study revealed that the thinnest patch (100 μm) delivered more than 45 % of the loaded drug. Drug delivery rate gradually reduced as the patch thickness increased, accounting for 22 % and 14 % drug permeation by 200 μm and 300 μm patches respectively. A 30-day stability study at room temperature demonstrated that neither the physical appearance nor the active ingredient content changed, validating the physical and chemical stability of the patches. Skin permeation mechanism by Fourier transform infrared spectroscopic analysis of the skin suggested that the IL/O patch possesses the capability to modify the lipid barrier in the stratum corneum thus facilitating drug diffusion. In vitro skin irritation studies on reconstructed human epidermal tissue and Yucatan micropig skin revealed that the patch exhibits no skin irritation. We believe that the adhesive nature of this newly developed IL-based patch holds significant promise as a transdermal drug delivery platform.

    DOI: 10.1016/j.molliq.2024.124184

    Web of Science

    Scopus

    researchmap

  • Engineering the Propeptide of Microbial Transglutaminase Zymogen: Enabling Substrate-Dependent Activation for Bioconjugation Applications. International journal

    Ryutaro Ariyoshi, Takashi Matsuzaki, Ryo Sato, Kosuke Minamihata, Kounosuke Hayashi, Taisei Koga, Kensei Orita, Riko Nishioka, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Bioconjugate chemistry   35 ( 3 )   340 - 350   2024.2   ISSN:1043-1802 eISSN:1520-4812

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Microbial transglutaminase (MTG) from Streptomyces mobaraensis is a powerful biocatalytic glue for site-specific cross-linking of a range of biomolecules and synthetic molecules that have an MTG-reactive moiety. The preparation of active recombinant MTG requires post-translational proteolytic digestion of a propeptide that functions as an intramolecular chaperone to assist the correct folding of the MTG zymogen (MTGz) in the biosynthesis. Herein, we report engineered active zymogen of MTG (EzMTG) that is expressed in soluble form in the host Escherichia coli cytosol and exhibits cross-linking activity without limited proteolysis of the propeptide. We found that the saturation mutagenesis of residues K10 or Y12 in the propeptide domain generated several active MTGz mutants. In particular, the K10D/Y12G mutant exhibited catalytic activity comparable to that of mature MTG. However, the expression level was low, possibly because of decreased chaperone activity and/or the promiscuous substrate specificity of MTG, which is potentially harmful to the host cells. The K10R/Y12A mutant exhibited specific substrate-dependent reactivity toward peptidyl substrates. Quantitative analysis of the binding affinity of the mutated propeptides to the active site of MTG suggested an inverse relationship between the binding affinity and the catalytic activity of EzMTG. Our proof-of-concept study provides insights into the design of a new biocatalyst using the MTGz as a scaffold and a potential route to high-throughput screening of EzMTG mutants for bioconjugation applications.

    DOI: 10.1021/acs.bioconjchem.3c00544

    Web of Science

    Scopus

    PubMed

    researchmap

  • A Functional Hydrogel Bead-Based High-Throughput Screening System for Mammalian Cells with Enhanced Secretion of Therapeutic Antibodies. International journal

    Diah Anggraini Wulandari, Kyosuke Tsuru, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    ACS biomaterials science & engineering   10 ( 1 )   628 - 636   2024.1   ISSN:2373-9878

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Droplet-based high-throughput screening systems are an emerging technology that provides a quick test to screen millions of cells with distinctive characteristics. Biopharmaceuticals, specifically therapeutic proteins, are produced by culturing cells that secrete heterologous recombinant proteins with different populations and expression levels; therefore, a technology to discriminate cells that produce more target proteins is needed. Here, we present a droplet-based microfluidic strategy for encapsulating, screening, and selecting target cells with redox-responsive hydrogel beads (HBs). As a proof-of-concept study, we demonstrate the enrichment of hybridoma cells with enhanced capability of antibody secretion using horseradish peroxidase (HRP)-catalyzed hydrogelation of tetra-thiolate poly(ethylene glycol); hybridoma cells were encapsulated in disulfide-bonded HBs. Recombinant protein G or protein M with a C-terminal cysteine residue was installed in the HBs via disulfide bonding to capture antibodies secreted from the cells. HBs were fluorescently stained by adding the protein L-HRP conjugate using a tyramide signal amplification system. HBs were then separated by fluorescence-activated droplet sorting and degraded by reducing the disulfide bonds to recover the target cells. Finally, we succeeded in the selection of hybridoma cells with enhanced antibody secretion, indicating the potential of this system in the therapeutic protein production.

    DOI: 10.1021/acsbiomaterials.3c01386

    Web of Science

    Scopus

    PubMed

    researchmap

  • L-Leucine Propyl Ester-Fatty Acid-Based Pseudo-Protic Ionic Liquids: Synthesis, Extraction Ability, and Ecotoxicity Prediction by Machine Learning

    Maghfirah, A; Fajar, ATN; Wakabayashi, R; Goto, M

    SOLVENT EXTRACTION RESEARCH AND DEVELOPMENT-JAPAN   31 ( 1 )   31 - 40   2024   ISSN:1341-7215

     More details

  • Ultrasonic-Assisted Synthesis of Silver Nanoparticle using Seaweed Ulva Lactuca Extract

    Muhammad Naufal Abrar, Safrina Dyah Hardiningtyas, Wahyu Ramadhan, Rie Wakabayashi, Budiono Ujaya Putra, Uju

    Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology   18 ( 2 )   129 - 138   2023.8   ISSN:2089-5690 eISSN:2406-9272

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    Ulva lactuca, a green seaweed that is widely distributed in Indonesia, is abundant but still underutilized. Even though this seaweed contains a sulfated polysaccharide called ulvan as much as 30-40% of its dry biomass and secondary metabolite. These components can be applied in various fields including as a reducing agent for silver ions in the bottom up synthesis of silver nanoparticles. The utilization of seaweed extract combined with ultrasonication is expected to enhance the efficacy of environmentally friendly silver nanoparticle synthesis. The objective of this study was to obtain the crude extract of U. lactuca and to investigate the impact of extract concentration and ultrasonication duration on the synthesis of silver nanoparticles. The study consists of two main phases: bio-synthesis employing different concentrations of the U. lactuca crude extract and bio-synthesis using selected extract concentrations combined with ultrasonic assistance for varying durations. The results of this study indicate that the crude extract of U. lactuca is a crude ulvan polysaccharide with a yield value and sulfate content of 26.9 ± 0.90% and 20.04 ± 1.02%, respectively. A reddish-brown color indicates the formation of silver nanoparticles. Based on the absorbance intensity, a 10% (v/v) concentration of ulvan crude extract produced the highest absorbance intensity (0.038 a.u). In addition, the ultrasonication duration of 60 minutes has succeeded in producing the smallest particle size (267.40 ± 6.52 nm) with a homogeneous particle distribution (PdI 0.265 ± 0.05). Scanning electron microscope (SEM) images depicted oval-shaped silver nanoparticles, while the Fourier-transform infrared (FTIR) spectrum indicated the degradation of sulfate and polysulfide functional groups in the crude extract during the synthesis process. These findings highlight the significant role of sulfate/sulfide groups present in the U. lactuca crude extract in the synthesis of silver nanoparticles.

    DOI: 10.15578/squalen.802

    Scopus

    researchmap

  • Non-Invasive Transdermal Delivery of Antisense Oligonucleotides with Biocompatible Ionic Liquids

    Kiyohiro Toyofuku, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    ACS Applied Materials & Interfaces   15 ( 28 )   33299 - 33308   2023.7   ISSN:1944-8244 eISSN:1944-8252

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsami.3c03900

    Web of Science

    Scopus

    PubMed

    researchmap

  • Modification with Conventional Surfactants to Improve a Lipid-Based Ionic-Liquid-Associated Transcutaneous Anticancer Vaccine

    Shihab Uddin, Md Rafiqul Islam, Rahman Md Moshikur, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    Molecules   28 ( 7 )   2023.4   eISSN:1420-3049

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    Transcutaneous vaccination is one of the successful, affordable, and patient-friendly advanced immunization approaches because of the presence of multiple immune-responsive cell types in the skin. However, in the absence of a preferable facilitator, the skin’s outer layer is a strong impediment to delivering biologically active foreign particles. Lipid-based biocompatible ionic-liquid-mediated nanodrug carriers represent an expedient and distinct strategy to permit transdermal drug delivery; with acceptable surfactants, the performance of drug formulations might be further enhanced. For this purpose, we formulated a lipid-based nanovaccine using a conventional (cationic/anionic/nonionic) surfactant loaded with an antigenic protein and immunomodulator in its core to promote drug delivery by penetrating the skin and boosting drug delivery and immunogenic cell activity. In a follow-up investigation, a freeze–dry emulsification process was used to prepare the nanovaccine, and its transdermal delivery, pharmacokinetic parameters, and ability to activate autoimmune cells in the tumor microenvironment were studied in a tumor-budding C57BL/6N mouse model. These analyses were performed using ELISA, nuclei and HE staining, flow cytometry, and other biological techniques. The immunomodulator-containing nanovaccine significantly (p < 0.001) increased transdermal drug delivery and anticancer immune responses (IgG, IgG1, IgG2, CD8+, CD207+, and CD103+ expression) without causing cellular or biological toxicity. Using a nanovaccination approach, it is possible to create a more targeted and efficient delivery system for cancer antigens, thereby stimulating a stronger immune response compared with conventional aqueous formulations. This might lead to more effective therapeutic and preventative outcomes for patients with cancer.

    DOI: 10.3390/molecules28072969

    Web of Science

    Scopus

    PubMed

    researchmap

  • Transdermal Transmission Blocking Vaccine for Malaria using a Solid-in-Oil Dispersion

    Keisuke Tanaka, Kosuke Minamihata, Rie Wakabayashi, Jae Man Lee, Takeshi Miyata, Takahiro Kusakabe, Noriho Kamiya, Masahiro Goto

    Journal of Pharmaceutical Sciences   112 ( 2 )   411 - 415   2023.2   ISSN:0022-3549 eISSN:1520-6017

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    Malaria is a mosquito-borne infectious disease that is widespread in developing countries. Malaria vaccines are important in efforts to eradicate malaria; however, vaccines are usually administered by injection, which requires medical personnel and has a risk of causing infection. Transdermal vaccines can be administered without damaging the skin and thus are ideal for the prevention of malaria. However, the stratum corneum forms a "brick and mortar" like structure in which stratum corneum cells are embedded in a hydrophobic matrix composed of lipids, which strongly inhibits the permeation of hydrophilic substances. In the present study, we designed a transdermal vaccine against vivax malaria using a solid-in-oil (S/O) dispersion. The S/O dispersion of a transmission blocking vaccine candidate, Pvs25 from Plasmodium vivax, showed higher skin penetration than that of the aqueous solution. Mice immunized with the S/O dispersion generated antibodies at similar titers as the mice immunized by injection, over the mid- to long-term. These results provide information for the development of transdermally administered malaria vaccines toward the eradication of malaria.

    DOI: 10.1016/j.xphs.2022.10.031

    Web of Science

    Scopus

    PubMed

    researchmap

  • Amino Acid Leaching of Critical Metals from Spent Lithium-Ion Batteries Followed by Selective Recovery of Cobalt Using Aqueous Biphasic System

    Chunqing Cai, Adroit T. N. Fajar, Takafumi Hanada, Rie Wakabayashi, Masahiro Goto

    ACS Omega   8 ( 3 )   3198 - 3206   2023.1   ISSN:2470-1343 eISSN:2470-1343

     More details

    Language:Others   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acsomega.2c06654

    Web of Science

    Scopus

    PubMed

    researchmap

  • Transformation of Hydrophilic Drug into Oil-Miscible Ionic Liquids for Transdermal Drug Delivery

    Rahman Md Moshikur, Islam Md Shimul, Shihab Uddin, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    ACS Applied Materials and Interfaces   14 ( 50 )   55332 - 55341   2022.12   ISSN:1944-8244 eISSN:1944-8252

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    The transdermal delivery of hydrophilic drugs remains challenging owing to their poor ability to permeate the skin; formulation with oil media is difficult without adding chemical permeation enhancers or co-solvents. Herein, we synthesized 12 oil-miscible ionic liquid (IL) drugs comprising lidocaine-, imipramine-, and levamisole (Lev)-hydrochloride with fatty acid permeation enhancers, i.e., laurate, oleate, linoleate, and stearate as counterions. A set of in vitro and in vivo studies was performed to investigate the potency and deliverability of the transdermal drug formulations. All of the synthesized compounds were freely miscible with pharmaceutically acceptable solvents/agents (i.e., ethanol, N-methyl pyrrolidone, Tween 20, and isopropyl myristate (IPM)). In vitro permeation studies revealed that the oleate-based Lev formulation had 2.6-fold higher skin permeation capability than the Lev salts and also superior ability compared with the laurate-, linoleate-, and stearate-containing samples. Upon in vivo transdermal administration to mice, the peak plasma concentration, elimination half-life, and area under the plasma concentration curve values of Lev-IL were 4.6-, 2.9-, and 5.4-fold higher, respectively, than those of the Lev salt. Furthermore, in vitro skin irritation and in vivo histological studies have demonstrated that Lev-IL has excellent biocompatibility compared with a conventional ionic liquid-based carrier. The results indicate that oil-miscible IL-based drugs provide a simple and scalable strategy for the design of effective transdermal drug delivery systems.

    DOI: 10.1021/acsami.2c15636

    Web of Science

    Scopus

    PubMed

    researchmap

  • Molecular crowding elicits the acceleration of enzymatic crosslinking of macromolecular substrates

    Ryo Sato, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Organic and Biomolecular Chemistry   21 ( 2 )   306 - 314   2022.11   ISSN:1477-0520 eISSN:1477-0539

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    Cytoplasm contains high concentrations of biomacromolecules. Protein behavior under such crowded conditions is reportedly different from that in an aqueous buffer solution, mainly owing to the effect of volume exclusion caused by the presence of macromolecules. Using a crosslinking reaction catalyzed by microbial transglutaminase (MTG) as a model, we herein systematically determined how the substrate size affects enzymatic activity in both dilute and crowded solutions of dextran. We first observed a threefold reduction in MTG-mediated crosslinking of a pair of small peptide substrates in 15 wt% dextran solution. In contrast, when proteinaceous substrates were involved, the crosslinking rates in 15 wt% dextran solutions accelerated markedly to levels comparable with the level in the absence of dextran. Our results provide new insights into the action of enzymes with regard to macromolecular substrates under crowded conditions, of which the potential utility was demonstrated by the formation of highly crosslinked protein polymers.

    DOI: 10.1039/d2ob01549h

    Web of Science

    Scopus

    PubMed

    researchmap

  • Protein-structure-dependent spectral shifts of near-infrared photoluminescence from locally functionalized single-walled carbon nanotubes based on avidin–biotin interactions Reviewed International journal

    Yoshiaki Niidome, Rie Wakabayashi, Masahiro Goto, Tsuyohiko Fujigaya, Tomohiro Shiraki

    Nanoscale   14 ( 36 )   13090 - 13097   2022.9   ISSN:2040-3364 eISSN:2040-3372

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Single-walled carbon nanotubes (SWCNTs) emit photoluminescence (PL) in the near-infrared (NIR) region (>900 nm). To enhance their PL properties, defect doping via local chemical functionalization has been developed. The locally functionalized SWCNTs (lf-SWCNTs) emit red-shifted and bright E11* PL originating from the excitons localized at the defect-doped sites. Here, we observe the E11* PL energy shifts induced by protein adsorption via the avidin-biotin interactions at the doped sites of lf-SWCNTs. We establish that the difference in the structures of the avidin derivatives notably influences the energy shifts. First, lf-SWCNT-tethering biotin groups (lf-SWCNTs-b) are synthesized based on diazonium chemistry, followed by post-modification. The responsiveness of the lf-SWCNTs-b to different microenvironments is investigated, and a correlation between the E11* PL energy shift and the induction-polarity parameters of surrounding solvents is established. The adsorption of neutravidin onto the lf-SWCNTs-b induces an increase in the induction-polarity parameters around the biotin-doped sites, resulting in the red-shift of the E11* PL peak. The E11* PL shift behaviors of the lf-SWCNTs-b change noticeably when avidin and streptavidin are introduced compared to the case with neutravidin. This is due to the different microenvironments formed at the biotin-doped sites, attributed to the difference in the structural features of the introduced avidin derivatives. Moreover, we successfully enhance the detection signals of lf-SWCNTs-b (>three fold) for streptavidin detection using a fabricated film device. Therefore, lf-SWCNTs exhibit significant promise for application in advanced protein detection/recognition devices based on NIR PL.

    DOI: 10.1039/d2nr01440h

    Web of Science

    Scopus

    PubMed

    researchmap

  • Artificial Palmitoylation of Proteins Controls the Lipid Domain-Selective Anchoring on Biomembranes and the Raft-Dependent Cellular Internalization

    Kazuki Uchida, Hiroki Obayashi, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto, Naofumi Shimokawa, Masahiro Takagi, Noriho Kamiya

    Langmuir   38 ( 31 )   9640 - 9648   2022.8   ISSN:0743-7463 eISSN:1520-5827

     More details

    Language:Others   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    Protein palmitoylation, a post-translational modification, is universally observed in eukaryotic cells. The localization of palmitoylated proteins to highly dynamic, sphingolipid- and cholesterol-rich microdomains (called lipid rafts) on the plasma membrane has been shown to play an important role in signal transduction in cells. However, this complex biological system is not yet completely understood. Here, we used a combined approach where an artificial lipidated protein was applied to biomimetic model membranes and plasma membranes in cells to illuminate chemical and physiological properties of the rafts. Using cell-sized giant unilamellar vesicles, we demonstrated the selective partitioning of enhanced green fluorescent protein modified with a C-terminal palmitoyl moiety (EGFP-Pal) into the liquid-ordered phase consisting of saturated phospholipids and cholesterol. Using Jurkat T cells treated with an immunostimulant (concanavalin A), we observed the vesicular transport of EGFP-Pal. Further cellular studies with the treatment of methyl beta-cyclodextrin revealed the cholesterol-dependent internalization of EGFP-Pal, which can be explained by a raft-dependent, caveolae-mediated endocytic pathway. The present synthetic approach using artificial and natural membrane systems can be further extended to explore the potential utility of artificially lipidated proteins at biological and artificial interfaces.

    DOI: 10.1021/acs.langmuir.2c01205

    Web of Science

    Scopus

    PubMed

    researchmap

  • Transdermal Delivery of Antigenic Protein Using Ionic Liquid-Based Nanocarriers for Tumor Immunotherapy

    Shihab Uddin, Md Rafiqul Islam, Rahman Md Moshikur, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    ACS Applied Bio Materials   5 ( 6 )   2586 - 2597   2022.6   ISSN:2576-6422 eISSN:2576-6422

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Transdermal drug delivery systems (TDDSs) may be useful for preventing various diseases including cancer. However, the stratum corneum (SC) inhibits the permeation of foreign particles into the skin. To obtain an effective TDDS, we developed a protein-containing nanocarrier (PCNC) comprising an antigenic protein (ovalbumin/OVA) stabilized by a combination of surfactants, i.e., a lipid-based surface-active ionic liquid and Tween-80. The PCNC was lyophilized to remove water and cyclohexane and then dispersed in isopropyl myristate. It is biocompatible both in vitro and in vivo, and is suitable for use in a therapeutic TDDS. The skin permeability of the PCNC was significantly (p < 0.0001) enhanced, and the transdermal distribution and transdermal flux of the OVA delivery system were 25 and 28 times greater, respectively, than those of its aqueous formulation. The PCNC disrupted the order of lipid orientation in the skin's SC and increased intercellular protein delivery. It demonstrated effective antitumor activity, drastically (p < 0.001) suppressed tumor growth, increased mouse survival rates, and significantly (p < 0.001) stimulated the OVA-specific tumor immune response. The PCNC also increased the number of cytotoxic T cells expressing CD8 antibodies on their surfaces (CD8 + T-cells) in the tumor microenvironment. These findings suggest that PCNCs may be promising biocompatible carriers for transdermal antigenic protein delivery in tumor immunotherapy.

    DOI: 10.1021/acsabm.2c00061

    Web of Science

    Scopus

    PubMed

    researchmap

  • A solid-in-oil-in-water emulsion: An adjuvant-based immune-carrier enhances vaccine effect

    Yoshiro Tahara, Riko Mizuno, Tomoki Nishimura, Sada atsu Mukai, Rie Wakabayashi, Noriho Kamiya, Kazunari Akiyoshi, Masahiro Goto

    Biomaterials   282   121385   2022.3   ISSN:0142-9612 eISSN:1878-5905

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    The biomaterial-based immunoengineering has become one of the most attractive research fields in the last decade. In the present study, a solid-in-oil-in-water (S/O/W) emulsion encapsulating antigen in the oil phase of an oil-in-water (O/W) emulsion was prepared as a novel vaccine carrier consisting of similar materials to the emulsion adjuvant of which the safety, immunogenicity and vaccination efficacy have been already confirmed in human. Direct observation by high-resolution confocal laser scanning microscopy and small angle X-ray scattering analysis showed that the antigens were dispersed inside of the oil phase of the S/O/W emulsion as solid-state particles. The S/O/W emulsion robustly produced antigen-specific antibodies and enhanced the antitumor effects in a therapeutic cancer vaccination compared with free antigens or the O/W emulsion in vivo. This result is in good agreement with the activation effect of antigen-specific cytotoxic T lymphocytes and antigen presentation by the S/O/W emulsion, indicating that the S/O/W emulsion consisting of already approved materials is a promising vaccine carrier to produce both humoral and cellular immunity.

    DOI: 10.1016/j.biomaterials.2022.121385

    Web of Science

    Scopus

    PubMed

    researchmap

  • Lyotropic liquid crystal-based transcutaneous peptide delivery system: Evaluation of skin permeability and potential for transcutaneous vaccination

    S. Kozaka, R. Wakabayashi, N. Kamiya, M. Goto

    Acta Biomaterialia   138   273 - 284   2022.1   ISSN:1742-7061 eISSN:1878-7568

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    Transcutaneous drug delivery is a promising method in terms of drug repositioning and reformulation because of its non-invasive and easy-to-use features. To overcome the skin barrier, which is the biggest challenge in transcutaneous drug delivery, a number of techniques, such as microemulsion, solid-in-oil dispersions and liposomes, have been studied extensively. However, the low viscosity of these formulations limits drug retention on the skin and reduces patient acceptability. Although viscosity can be increased by adding a thickening reagent, such an addition often alters formulation nanostructures and drug solubility, and importantly, decreases skin permeability. In this study, a gel-like lyotropic liquid crystal (LLC) was used as a tool to enhance skin permeability. In particular, we prepared 1-monolinolein (ML)-based LLCs with different water contents. All LLCs significantly enhanced skin permeation of a peptide drug, an epitope peptide of melanoma, despite their high viscoelasticity. Fourier transform infra-red spectroscopic analysis of the skin surface treated with the LLCs revealed that the gyroid geometry more strongly interacted with the lamellar structure inside the stratum corneum (SC) than the diamond geometry. Finally, as the result of the in vivo tumor challenge experiment using B16F10 melanoma-bearing mice, the LLC with the gyroid geometry showed stronger vaccine effect against tumor than a subcutaneous injection. Collectively, ML-based LLCs, especially with the gyroid geometry, are a promising strategy to deliver biomacromolecules into skin. Statement of significance: Transcutaneous drug delivery is a promising method for drug repositioning and reformulation because of its non-invasive and easy-to-use features. To overcome the skin barrier, which is the biggest challenge in transcutaneous drug delivery, we used a gel-like lyotropic liquid crystal (LLC) as a novel tool to enhance skin permeability. In this paper, we demonstrated that an LLC with a specific liquid crystalline structure has the highest skin permeation enhancement effect for a peptide antigen as a model drug. Moreover, the peptide antigen-loaded LLC showed a vaccine effect that was comparable to a subcutaneous injection in vivo. This study provides a basis for designing a transcutaneous delivery system of peptide drugs with LLC.

    DOI: 10.1016/j.actbio.2021.11.008

    Web of Science

    Scopus

    PubMed

    researchmap

  • Design of Swollen Lipidic Cubic Phase to Increase Transcutaneous Penetration of Biomacromolecules

    Shuto Kozaka, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    ACS Applied Materials and Interfaces   13 ( 46 )   54753 - 54761   2021.11

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsami.1c16659

  • Methotrexate-based ionic liquid as a potent anticancer drug for oral delivery: In vivo pharmacokinetics, biodistribution, and antitumor efficacy

    Rahman Md Moshikur, Md Korban Ali, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   608   2021.10

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijpharm.2021.121129

  • Insulin Transdermal Delivery System for Diabetes Treatment Using a Biocompatible Ionic Liquid-Based Microemulsion

    Md Rafiqul Islam, Shihab Uddin, Md Raihan Chowdhury, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    ACS Applied Materials and Interfaces   13 ( 36 )   42461 - 42472   2021.9

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsami.1c11533

  • Favipiravir-Based Ionic Liquids as Potent Antiviral Drugs for Oral Delivery: Synthesis, Solubility, and Pharmacokinetic Evaluation

    Rahman Md Moshikur, Md Korban Ali, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    Molecular Pharmaceutics   18 ( 8 )   3108 - 3115   2021.8

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.1c00324

  • Lipid-Based Ionic-Liquid-Mediated Nanodispersions as Biocompatible Carriers for the Enhanced Transdermal Delivery of a Peptide Drug

    Shihab Uddin, Md Rafiqul Islam, Md Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    ACS Applied Bio Materials   4 ( 8 )   6256 - 6267   2021.8

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsabm.1c00563

  • Biocompatible ionic liquids assisted transdermal co-delivery of antigenic protein and adjuvant for cancer immunotherapy Reviewed International journal

    Chowdhury Md Raihan, Rahman Md. Moshikur, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   601   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijpharm.2021.120582

  • Biocompatible Ionic Liquid-Mediated Micelles for Enhanced Transdermal Delivery of Paclitaxel Reviewed International journal

    Md. Korban Ali, Rahman Md. Moshikur, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    ACS Applied Materials Interfaces   13 ( 17 )   19745 - 19755   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsami.1c03111

  • Extending the Half-Life of a Protein in Vivo by Enzymatic Labeling with Amphiphilic Lipopeptides Reviewed International journal

    Mari Takahara, Shinichi Mochizuki, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Kazuo Sakurai, Noriho Kamiya

    Bioconjugate Chemistry   32 ( 4 )   655 - 660   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.bioconjchem.1c00027

  • Co-amorphous formation of piroxicam-citric acid to generate supersaturation and improve skin permeation. International journal

    Yuya Hirakawa, Hiroshi Ueda, Yusuke Takata, Kosuke Minamihata, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences   158   105667 - 105667   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejps.2020.105667

  • Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel Reviewed

    Wahyu Ramadhan, Genki Kagawa, Kousuke Moriyama, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Scientific reports   10 ( 1 )   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-63362-4

  • Formation and potential application of micelles composed of biocompatible N-lauroyl-amino acid ionic liquids surfactant Reviewed International journal

    Rahman Md Moshikur, Md. Korban Ali, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   320   114424   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molliq.2020.114424

  • Dual-functionalizable streptavidin-SpyCatcher fused protein-polymer hydrogels as scaffolds for cell culture Reviewed International journal

    Kosuke Minamihata, Yusei Hamada, Genki Kagawa, Wahyu Ramadhan, Ayato Higuchi, Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   3   7734 - 7742   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsabm.0c00940

  • Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation Reviewed International journal

    Shihab Uddin, Md Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Chemical Communications   56   13756 - 13759   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/D0CC04491A

  • Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids Reviewed

    Wahyu Ramadhan, Yuki Ohama, Kosuke Minamihata, Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Journal of Bioscience and Bioengineering   130 ( 4 )   416 - 423   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbiosc.2020.05.010

  • Effective transcutaneous delivery of hyaluronic acid using an easy-to-prepare reverse micelle formulation Reviewed

    Shuto Kozaka, Ayaka Kashima, Rie Wakabayashi, Takahiro Nakata, Taro Ueda, Masahiro Goto

    Cosmetics   7 ( 3 )   2020.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/COSMETICS7030052

  • Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect Reviewed

    Yoshiro Tahara, Kaho Morita, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Molecular pharmaceutics   2020.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.0c00598

  • Design and characterization of fatty acid-based amino acid ester as a new “green” hydrophobic ionic liquid for drug delivery Reviewed International journal

    8   13660 - 13671   2020.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acssuschemeng.0c03419

  • PolyTag A peptide tag that affords scaffold-less covalent protein assembly catalyzed by microbial transglutaminase: Design of PolyTag for scaffold-less covalent protein assembly Reviewed

    R. Sato, K. Minamihata, R. Wakabayashi, M. Goto, N. Kamiya

    Analytical Biochemistry   600   2020.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ab.2020.113700

  • Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir Reviewed

    Md Rafiqul Islam, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   582   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijpharm.2020.119335

  • Biocompatible Ionic Liquid Surfactant-Based Microemulsion as a Potential Carrier for Sparingly Soluble Drugs Reviewed

    Md. Korban Ali, Rahman Md Moshikur, Rie Wakabayashi, Muhammad Moniruzzaman, Noriho Kamiya, Masahiro Goto

    ACS Sustainable Chemistry & Engineering   2020.4

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acssuschemeng.9b07773

  • Ionic liquid-in-oil microemulsions prepared with biocompatible choline carboxylic acids for improving the transdermal delivery of a sparingly soluble drug Reviewed

    Md Rafiqul Islam, Md Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Pharmaceutics   12 ( 4 )   2020.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/pharmaceutics12040392

  • A novel binary supercooled liquid formulation for transdermal drug delivery Reviewed

    Yuya Hirakawa, Hiroshi Ueda, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Biological and Pharmaceutical Bulletin   43 ( 3 )   393 - 398   2020.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/bpb.b19-00642

  • Linear Polymerization of Protein by Sterically Controlled Enzymatic Cross-Linking with a Tyrosine-Containing Peptide Loop Reviewed

    Dani Permana, Kosuke Minamihata, Ryo Sato, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    ACS Omega   5 ( 10 )   5160 - 5169   2020.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsomega.9b04163

  • Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery Synthesis, characterization, and skin-penetration evaluation Reviewed

    Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   299   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molliq.2019.112166

  • Transcutaneous Cancer Vaccine Using a Reverse Micellar Antigen Carrier Reviewed

    Shuto Kozaka, Yoshiro Tahara, Rie Wakabayashi, Takahiro Nakata, Taro Ueda, Noriho Kamiya, Masahiro Goto

    Molecular pharmaceutics   17 ( 2 )   645 - 655   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.9b01104

  • Solid-in-oil nanodispersions for intranasal vaccination Enhancement of mucosal and systemic immune responses Reviewed

    Qingliang Kong, Momoko Kitaoka, Yoshiro Tahara, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   572   2019.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijpharm.2019.118777

  • Transcutaneous delivery of immunomodulating pollen extract-galactomannan conjugate by solid-in-oil nanodispersions for pollinosis immunotherapy Reviewed

    Qingliang Kong, Kouki Higasijima, Rie Wakabayashi, Yoshiro Tahara, Momoko Kitaoka, Hiroki Obayashi, Yanting Hou, Noriho Kamiya, Masahiro Goto

    Pharmaceutics   11 ( 11 )   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/pharmaceutics11110563

  • Synthesis and characterization of choline–fatty-acid-based ionic liquids A new biocompatible surfactant Reviewed

    551   72 - 80   2019.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jcis.2019.04.095

  • A nano-sized gel-in-oil suspension for transcutaneous protein delivery Reviewed

    Safrina Dyah Hardiningtyas, Seiya Nagao, Emiko Yamamoto, Nana Shirakigawa, Rie Wakabayashi, Masahiro Goto, Hiroyuki Ijima, Noriho Kamiya

    International Journal of Pharmaceutics   567   2019.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijpharm.2019.118495

  • In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations Reviewed

    Md Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   565   219 - 226   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijpharm.2019.05.020

  • Enzymatically Prepared Dual Functionalized Hydrogels with Gelatin and Heparin to Facilitate Cellular Attachment and Proliferation Reviewed

    Wahyu Ramadhan, Genki Kagawa, Yusei Hamada, Kousuke Moriyama, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   2 ( 6 )   2600 - 2609   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsabm.9b00275

  • Ionic liquids with methotrexate moieties as a potential anticancer prodrug Synthesis, characterization and solubility evaluation Reviewed

    Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   278   226 - 233   2019.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molliq.2019.01.063

  • Self-Assembled Reduced Albumin and Glycol Chitosan Nanoparticles for Paclitaxel Delivery Reviewed

    Muhamad Alif Razi, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Langmuir   35 ( 7 )   2610 - 2618   2019.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.langmuir.8b02809

  • Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity Reviewed

    Md Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Chemical Communications   55 ( 54 )   7737 - 7740   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c9cc02812a

  • Enzymatic Cell-Surface Decoration with Proteins using Amphiphilic Lipid-Fused Peptide Substrates Reviewed International journal

    Mari Takahara, Rie Wakabayashi, Naoki Fujimoto, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Chemistry - A European Journal   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.201900370

  • Enhanced potential of therapeutic applications of curcumin using solid-in-water nanodispersion technique Reviewed

    Safrina Dyah Hardiningtyas, Rie Wakabayashi, Ryutaro Ishiyama, Yuki Owada, Masahiro Goto, Noriho Kamiya

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   52 ( 1 )   138 - 143   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1252/jcej.18we060

  • Effect of macromolecular crowding on the conformational behaviour of a porphyrin rotor Reviewed

    Shuto Kozaka, Rie Wakabayashi, Onofrio Annunziata, Milan Balaz, Masahiro Goto, Noriho Kamiya, Sergei V. Dzyuba

    Journal of Photochemistry and Photobiology A: Chemistry   369   115 - 118   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jphotochem.2018.10.006

  • Liquid Marbles as an Easy-to-Handle Compartment for Cell-Free Synthesis and In Situ Immobilization of Recombinant Proteins Reviewed International journal

    Noriho Kamiya, Yuki Ohama, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto

    Biotechnology Journal   13 ( 12 )   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/biot.201800085

  • Design of Lipid-Protein Conjugates Using Amphiphilic Peptide Substrates of Microbial Transglutaminase Reviewed

    Mari Takahara, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   1 ( 6 )   1823 - 1829   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsabm.8b00271

  • Characterization and cytotoxicity evaluation of biocompatible amino acid esters used to convert salicylic acid into ionic liquids Reviewed International journal

    Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   546 ( 1-2 )   31 - 38   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijpharm.2018.05.021

  • Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination Reviewed

    Michiaki Kumagai, Shinya Shimoda, Rie Wakabayashi, Yumi Kunisawa, Takehiko Ishii, Kensuke Osada, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka, Kenji Nakano

    JOURNAL OF CONTROLLED RELEASE   160 ( 3 )   542 - 551   2012.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jconrel.2012.03.021

  • Impaired activities of cyclic adenosine monophosphate-responsive element binding protein, protein kinase A and calcium-independent phospholipase A2 are involved in deteriorated regeneration of cirrhotic liver after partial hepatectomy in rats Reviewed

    Gang Zhao, Rie Wakabayashi, Shinya Shimoda, Yumi Fukunaga, Michiaki Kumagai, Masao Tanaka, Kenji Nakano

    HEPATOLOGY RESEARCH   41 ( 11 )   1110 - 1119   2011.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1872-034X.2011.00868.x

  • Dual blockade of phosphatidylinositol 3 '-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer Reviewed

    Rui Xu, Kenji Nakano, Hironori Iwasaki, Michiaki Kumagai, Rie Wakabayashi, Akio Yamasaki, Hiroyuki Suzuki, Ryuichi Mibu, Hideya Onishi, Mitsuo Katano

    CANCER LETTERS   306 ( 2 )   151 - 160   2011.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.canlet.2011.02.042

  • Mechanically Interlocked Porphyrin Gears Propagating Two Different Rotational Frequencies Reviewed

    Soichiro Ogi, Tomohiro Ikeda, Rie Wakabayashi, Seiji Shinkai, Masayuki Takeuchi

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   ( 10 )   1831 - 1836   2011.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ejoc.201001656

  • Olefin metathesis of the aligned assemblies of conjugated polymers constructed through supramolecular bundling Reviewed

    Rie Wakabayashi, Yohei Kubo, Kenji Kaneko, Masayuki Takeuchi, Seiji Shinkai

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   128 ( 27 )   8744 - 8745   2006.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja063040x

▼display all

Books

Presentations

  • 抗原タンパク質修飾ペプチドファイバーの細胞内取り込み制御

    若林里衣、樋口亜也斗、難波江友紀、神谷典穂、後藤雅宏

    日本化学会第104年会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:日本大学  

  • Supramolecular peptide fibers with enzymatic reactivity as a scaffold for antigenic protein delivery Invited

    Rie Wakabayashi

    2023.11 

     More details

    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Supramolecular architectures based on peptides and their interaction with cells Invited International conference

    Rie Wakabayashi

    International Mini-Symposium on Peptide Design and Functional Extension  2023.11 

     More details

    Event date: 2023.11

    Language:English   Presentation type:Oral presentation (general)  

  • Design and interfacial functions of hybrid supramolecules based on peptide amphiphiles Invited

    Rie Wakabayashi

    2023.8 

     More details

    Event date: 2023.8

    Language:English   Presentation type:Oral presentation (general)  

  • Bottom-up construction of functional molecular assemblies based on peptides and proteins Invited

    Rie Wakabayashi

    2023.7 

     More details

    Event date: 2023.7

    Language:English   Presentation type:Oral presentation (general)  

  • 共集合型超分子の相移行性

    若林 里衣, 大林 洋貴, 神谷 典穂, 後藤 雅宏

    日本化学会第103回春季年会2023,  2023.3 

     More details

    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京理科大学   Country:Japan  

  • Enzyme-reactive supramolecular peptide fibers for potential vaccine application Invited International conference

    Rie Wakabayashi

    2023.3 

     More details

    Event date: 2023.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Bottom-up fabrication of peptide supramolecules and their membrane permeability Invited International conference

    Rie Wakabayashi

    Kyushu U-NTNU joint symposium  2022.11 

     More details

    Event date: 2022.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 水圏機能ペプチド超分子の創製と細胞作用 Invited

    若林 里衣

    物性女性若手研究交流会2022  2022.11 

     More details

    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学   Country:Japan  

  • 機能性ペプチド超分子のボトムアップ構築 Invited

    若林 里衣

    2022.10 

     More details

    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • ペプチドやタンパク質を自在に配置したバイオミメティック超分子のボトムアップ構築 Invited

    若林 里衣

    「細胞を創る」研究会15.0  2022.10 

     More details

    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京工業大学   Country:Japan  

  • Design of self-assembly peptides for antigenic protein delivery application International conference

    R. Wakabayashi, A. Higuchi, M. Goto, N. Kamiya

    The 15th Asian Congress on Biotechnology  2022.10 

     More details

    Event date: 2022.10

    Language:English  

    Country:Indonesia  

  • 相補的水素結合で形成される共集合型超分子の細胞膜透過性

    若林 里衣, 大林 洋貴, 神谷 典穂, 後藤 雅宏

    第16回バイオ関連シンポジウム  2022.9 

     More details

    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋大学   Country:Japan  

  • Self-assembled peptide fibers with enzymatic reactivity for potential delivery of biotherapeutics International conference

    R. Wakabayashi, A. Higuchi, M. Goto, N. Kamiya

    APCChE 2022  2022.8 

     More details

    Event date: 2022.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Malaysia  

  • ペプチド性超分子を用いたドラッグデリバリー Invited

    若林里衣

    2022年度GSCセミナー・高分子研究会「有機材料化学の最前線」  2022.7 

     More details

    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鳥取大学/オンライン   Country:Japan  

  • Supramolecular biomaterials based on molecular self-assembly and biochemical engineering Invited

    Rie Wakabayashi

    Shinnen Suisan Gakkai FFMS-IPB University 2022 IPB  2022.7 

     More details

    Event date: 2022.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Indonesia  

  • ペプチド・タンパク質を用いた機能性分子集合体の構築 Invited

    若林里衣

    高分子学会九州支部若手会  2022.7 

     More details

    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:崇城大学   Country:Japan  

  • Biofunctional materials constructed by hierarchical organization of self-assembling peptides Invited

    Rie Wakabayashi

    2022.3 

     More details

    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 両親媒性ペプチドを用いた機能性分子集合体の構築 Invited

    若林里衣

    化学工学会第87年会  2022.3 

     More details

    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 自己組織化ペプチドファイバーを用いたドラッグデリバリー Invited

    若林里衣

    化学工学会第87年会  2022.3 

     More details

    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • Size-controlled co-assembly of peptide amphiphiles and small molecules via complementary interaction and its cellular internalization Invited International conference

    Rie Wakabayashi, Hiroki Obayashi, Noriho Kamiya, Masahiro Goto

    PacificChem2021  2021.12 

     More details

    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • タンパク質の事後修飾が可能な自己組織化ペプチドファイバーの創製とワクチンへの展開

    若林里衣、Syahid Fathullah Ghazian Dzaky、樋口亜也斗、後藤雅宏、神谷典穂

    化学工学会第52回秋季大会  2021.9 

     More details

    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • ペプチドファイバーへのタンパク質修飾とワクチン応用

    若林里衣、Syahid Fathullah Ghazian Dzaky、樋口亜也斗、後藤雅宏、神谷典穂

    第15回バイオ関連化学シンポジウム  2021.9 

     More details

    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 酵素反応性自己組織化ペプチドの製剤化に向けた基礎検討

    若林里衣、Syahid Fathullah Ghazian Dzaky, Cui Honggang, 神谷典穂、後藤雅宏

    第70回高分子学会年会  2021.5 

     More details

    Event date: 2021.5

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 自己組織化ペプチドの共集合制御と細胞接着性

    若林里衣、今谷梨乃、神谷典穂、後藤雅宏

    日本化学会第101春季年会  2021.3 

     More details

    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • ペプチド・タンパク質の組織化によるバイオ機能材料の創製 Invited

    若林里衣

    第3回FBC特別シンポジウム2020  2020.11 

     More details

    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 環境応答型の水圏機能ペプチド材料の創製 Invited

    若林里衣

    第10回CSJ化学フェスタ2020  2020.10 

     More details

    Event date: 2019.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • Designer drug delivery carriers constructed through a complementary interaction introduced to self-assembling peptide amphiphiles and a small molecular drug International conference

    Hiroki Obayashi, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    18th Asian Pacific Confederation of Chemical Engineering Congress  2019.9 

     More details

    Event date: 2019.9

    Language:English  

    Country:Japan  

  • 相補的相互作用を用いた共集合体の形態制御と細胞内デリバリー

    若林里衣、大林洋貴、神谷典穂、後藤雅宏

    第14回バイオ関連化学シンポジウム  2020.9 

     More details

    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • ペプチドとの相補的複合化による小分子の細胞内デリバリー

    若林里衣、大林洋貴、神谷典穂、後藤雅宏

    第13回バイオ関連化学シンポジウム  2019.9 

     More details

    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東北大学   Country:Japan  

  • 自己選別能の調節による両親媒性ペプチドの共集積制御

    若林里衣、今谷梨乃、神谷典穂、後藤雅宏

    生体機能関連化学部会若手の会 第31回サマースクール  2019.7 

     More details

    Event date: 2019.7

    Language:Japanese  

    Venue:セミナーハウス(東京都八王子市)   Country:Japan  

  • Intracellular delivery of small molecular drugs by complementary interaction with peptide amphiphiles International conference

    Rie Wakabayashi, Hiroki Obayashi, Noriho Kamiya, Masahiro Goto

    The 14th Asian Congress on Biotechnology  2019.7 

     More details

    Event date: 2019.7 - 2018.7

    Language:English  

    Country:Taiwan, Province of China  

  • タンパク質の事後集積を指向した酵素反応性の自己組織化ペプチドの開発

    若林里衣, 後藤雅宏, 神谷典穂

    日本化学会第99春季年会  2019.3 

     More details

    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:甲南大学   Country:Japan  

  • Controlled co-assembly of peptide amphiphiles to form biomimetic nanofibers Invited International conference

    R. Wakabayashi

    2018.12 

     More details

    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • ペプチドを構成要素とする複合型分子集積 Invited

    若林里衣

    東京大学化学生命工学専攻 2018年度談話会  2018.12 

     More details

    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学   Country:Japan  

  • Complemantary interaction with peptide amphiphiles guided the intracellular delivery of small molecular drugs International conference

    Rie Wakabayashi, Hiroki Obayashi, Noriho Kamiya, Masahiro Goto

    YABEC 2018  2018.11 

     More details

    Event date: 2018.11

    Language:English  

    Country:Taiwan, Province of China  

  • Controlled assembly of peptide amphiphiles and their application for drug delivery Invited International conference

    Rie Wakabayashi

    KIChE-SCEJ joint symposium I, Fall Symposium 2018 of KIChE  2018.10 

     More details

    Event date: 2018.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • 両親媒性ペプチドを用いたマルチドメイン型分子集積の試み

    若林里衣、勝家睦洋、今谷梨乃、神谷典穂、後藤雅宏

    第12回バイオ関連化学シンポジウム  2018.9 

     More details

    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪大学   Country:Japan  

  • 両親媒性ペプチドの共集合制御

    若林里衣、神谷典穂、後藤雅宏

    生体機能関連化学部会若手の会 第30回サマースクール  2018.7 

     More details

    Event date: 2018.7

    Language:Japanese  

    Venue:ANAホリデイ・イン リゾート宮崎   Country:Japan  

  • Solid-in-Oil 化経皮製剤によるがんの免疫治療効果

    若林里衣、河野秀俊、田原義朗、神谷典穂、後藤雅宏

    第34回日本DDS学会学術集会  2018.6 

     More details

    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎ブリックホール   Country:Japan  

  • ペプチド構造体へのタンパク質集積化 Invited

    若林里衣

    日本化学会第98春季年会2018  2018.3 

     More details

    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:日本大学   Country:Japan  

  • Multi-block fibrous assembly of peptide amphiphiles based on intrinsic immiscibility International conference

    R. Wakabayashi, M. Katsuya, N. Kamiya, M. Goto

    The Second International Symposium on Biofunctional Chemistry (ISBC2017)  2017.12 

     More details

    Event date: 2017.12

    Language:English  

    Country:Japan  

  • 自己認識を利用したドメイン型集合の試み Invited

    若林里衣

    2017.10 

     More details

    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:志賀島休暇村   Country:Japan  

  • 相補的相互作用を活用した小分子薬物のデリバリーキャリア開発

    若林里衣、橋本龍一朗、大林洋貴、神谷典穂、後藤雅宏

    第11回バイオ関連化学シンポジウム  2017.9 

     More details

    Event date: 2017.9

    Language:Japanese  

    Venue:東京大学   Country:Japan  

  • Solid-in-Oil 化技術を用いたメラノーマに対する経皮ワクチンの開発

    若林里衣、桜木優人、田原義朗、神谷典穂、後藤雅宏

    第33回日本DDS学会学術集会  2017.7 

     More details

    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:みやこめっせ   Country:Japan  

  • 自己集合ペプチドを使ったタンパク質集積化材料開発

    若林里衣、後藤雅宏、神谷典穂

    第6回 JACI/GSCシンポジウム  2017.7 

     More details

    Event date: 2017.7

    Language:Japanese  

    Venue:東京国際フォーラム   Country:Japan  

  • 酵素反応性ペプチドを用いたタンパク質の集積化

    若林里衣、後藤雅宏、神谷典穂

    第66回高分子学会年次大会  2017.5 

     More details

    Event date: 2017.5

    Language:Japanese  

    Venue:幕張メッセ   Country:Japan  

  • Bottom-up construction of cooperative interactions for a good ensemble Invited

    Rie Wakabayashi

    11th CSJ Chemistry Festa  2021.10 

     More details

    Language:Others  

    Country:Other  

  • 両親媒性ペプチド集合体のダイナミクスが細胞内取り込みに与え る影響

    藤原裕大、若林里衣、神谷典穂、後藤雅宏

    日本化学会第104春季年会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば  

  • 末端配列の改変による両親媒性ペプチド共集合体の階層構造制御と液-液相分離環境での局在観察

    水口敬貴・若林里衣・神谷典穂・後藤雅宏

    日本化学会 第104春季年会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:日本大学船橋キャンパス  

  • Enhancing Cellular Uptake of Nucleic Acid Drug by Co-assembly of Peptide Amphiphile

    Ingram Tan, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    104th CSJ annual meeting  2024.3 

     More details

    Event date: 2024.3

    Language:English   Presentation type:Oral presentation (general)  

  • 経皮マラリアワクチンの創製および効果の検証

    田中 敬佑、南畑 孝介、若林 里衣、神谷 典穂、後藤 雅宏

    化学工学会第89年会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪公立大学  

  • Formulation, Characterization, and Evaluation of Ionic Liquid-Based Transdermal Patch for Enhanced Delivery of Sparingly Soluble Drug International conference

    Islam R, Nabila FH, Wakabayashi R, Kamiya N, Moniruzaman M, Got M

    IChES2024  2024.3 

     More details

    Event date: 2024.3

    Language:English   Presentation type:Oral presentation (general)  

  • Amorphous Cellulose Nanofiber from Green Seaweed Ulva lactuca Prepared with Deep Eutectic Solvent Pretreatment International conference

    Rizfi Fariz Pari, Uju, Wahyu Ramadhan, Safrina Dyah Hardiningtyas, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    International Chemical Engineering Symposia 2024  2024.3 

     More details

    Event date: 2024.3

    Language:English   Presentation type:Oral presentation (general)  

  • A functional hydrogel bead-based high-throughput screening system for mammalian cells with enhanced secretion of therapeutic antibodies

    Diah Anggraini Wulandari, Kyosuke Tsuru, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto, and Noriho Kamiya

    International Chemical Engineering Symposia 2024  2024.3 

     More details

    Event date: 2024.3

    Language:English   Presentation type:Oral presentation (general)  

  • 人工的な脂質化によるタンパク質の膜ダイナミクス制御と詳細解析

    内田和希, 若林里衣, 後藤雅宏, 下川直史, 高木昌宏, 神谷典穂

    化学工学会 第89年会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪公立大学  

  • 核酸医薬の経皮吸収を促進するイオン液体製剤の開発

    豊福淳大、若林里衣、神谷典穂、後藤雅宏

    化学工学会第89年会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese  

    Venue:大阪公立大学 中百舌鳥キャンパス  

  • ペプチド製剤の経皮吸収製剤化を目指した深共晶溶媒の利用

    藤田尚明 田中敬佑 若林里衣 神谷典穂 後藤雅宏

    化学工学会 大会26回 学生発表会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  • 配列改変が両親媒性ペプチド共集合体の階層構造と液-液相分離下での局在に及ぼす影響

    水口敬貴・若林里衣・神谷典穂・後藤雅宏

    第26回化学工学会学生発表会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  • 細胞内取り込みにおける両親媒性ペプチド集合体のダイナミクスの影響

    藤原裕大、若林里衣、神谷典穂、後藤雅宏

    化学工学会学生発表会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  • The Effect of Deep Eutectic Solvent Pretreatment on Seaweed Cellulose for Cellulose Nanofiber Formation International conference

    Rizfi Fariz Pari, Uju, Wahyu Ramadhan, Safrina Dyah Hardiningtyas3, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    The 9 th International Symposium on Applied Chemistry 2023  2023.12 

     More details

    Event date: 2023.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Indonesia  

  • Creation of Vaccine Adjuvants Using Antigenic Protein Modified Peptide Assemblies International conference

    2023.12 

     More details

    Event date: 2023.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Hybrid protein crystal formation mediated by the interaction of positively charged peptide tags and oligo ssDNAs International conference

    The 34th International Symposium on Chemical Engineering  2023.12 

     More details

    Event date: 2023.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Artificial lipidation of proteins controls protein dynamics on lipid membranes International conference

    Kazuki Uchida, Rie Wakabayashi, Masahiro Goto, Naofumi Shimokawa, Masahiro Takagi, Noriho Kamiya

    The 34th International Symposium on Chemical Engineering  2023.12 

     More details

    Event date: 2023.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Effect of hydrophobic portions of antigen-modified peptide assemblies on immune cell activation International conference

    ISChE2023  2023.12 

     More details

    Event date: 2023.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Creation of a new ionic liquid-based drug delivery system for antibody drugs International conference

    Shunsuke Kurazono, Rie Wakabayashi, Masahiro Goto

    The 34th International Symposium on Chemical Engineering  2023.12 

     More details

    Event date: 2023.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Non-invasive transdermal delivery of nucleic acid drugs with biocompatible ionic liquids International conference

    The 34th International Symposium on Chemical Engineering (ISChE 2023)  2023.12 

     More details

    Event date: 2023.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Development of a non-invasive malaria vaccine and analysis of the immune mechanism International conference

    Keisuke Tanaka, Kosuke Minamihata, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    ISChE2023  2023.12 

     More details

    Event date: 2023.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Peptide Amphiphile Co-assembly Facilitated Direct Cellular Delivery of Antisense Oligonucleotides International conference

    Ingram Tan, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    international symposium on chemical engineering  2023.12 

     More details

    Event date: 2023.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Development of transdermal delivery technology for mRNA drugs using ionic liquids International conference

    International Symposium on Chemical Engineering  2023.12 

     More details

    Event date: 2023.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • イオン液体を利用したmRNA医薬の経皮送達技術の開発

    東智大、豊福淳大、若林里衣、神谷憲穂、後藤雅宏

    日本膜学会第45年会・膜シンポジウム2023合同大会  2023.11 

     More details

    Event date: 2023.11

    Language:Japanese  

    Venue:早稲田大学先進研究センター  

  • 非侵襲的な糖尿病治療を目指した経皮GLP-1 RA製剤の開発

    松尾碧湖、若林里衣、神谷典穂、後藤雅宏

    膜シンポジウム  2023.11 

     More details

    Event date: 2023.11

    Language:Japanese  

    Venue:早稲田大学リサーチイノベーションセンター  

  • 生体適合性イオン液体を用いた核酸医薬の経皮・細胞内送達

    豊福淳大、若林里衣、神谷典穂、後藤雅宏

    日本膜学会第45年会・膜シンポジウム2023合同大会  2023.11 

     More details

    Event date: 2023.11

    Language:Japanese  

    Venue:早稲田大学リサーチイノベーションセンター  

  • 計算化学を用いた生体高分子の経皮送達における浸透促進剤の効果予測モデルの開発

    田中 敬佑、若林 里衣、神谷 典穂、後藤 雅宏

    日本膜学会「第45年会」・「膜シンポジウム2023」合同大会  2023.11 

     More details

    Event date: 2023.11

    Language:Japanese  

    Venue:早稲田大学リサーチイノベーションセンター(121号館)B1F  

  • Transdermal delivery of nucleic acid drugs using biocompatible ionic liquid International conference

    The 25th Joint Seminar of the Busan Branch of the Korean Chemical Society (KCS) and the Kyushu Branch of the Chemical Society of Japan (CSJ)  2023.11 

     More details

    Event date: 2023.11

    Language:English  

    Country:Korea, Republic of  

  • 超分子集合体を用いた免疫細胞の活性化

    山口恭平・若林里衣・神谷典穂・後藤雅宏

    第9回九州地区大学-高専研究・教育セミナー  2023.11 

     More details

    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本大学  

  • 抗原タンパク質修飾ペプチド集合体の表面電荷制御と細胞内取り込み評価

    難波江友紀、樋口亜也斗、若林里衣、神谷典穂、後藤雅宏

    第13回 CSJ化学フェスタ 2023  2023.10 

     More details

    Event date: 2023.10

    Language:Japanese  

    Venue:タワーホール船堀  

  • 免疫細胞の活性化に抗原修飾ペプチド集合体の疎水部が及ぼす影響

    山口恭平・若林里衣・神谷典穂・後藤雅宏

    日本化学会秋季事業 第13回 CSJ化学フェスタ 2023  2023.10 

     More details

    Event date: 2023.10

    Language:Japanese  

    Venue:タワーホール船堀  

  • Artificial protein lipidation and its dynamics on lipid membranes International conference

    Kazuki Uchida, Rie Wakabayashi, Masahiro Goto, Naofumi Shimokawa, Masahiro Takagi, Noriho Kamiya

    The 16th Asian Congress on Biotechnology (ACB)  2023.10 

     More details

    Event date: 2023.10

    Language:English  

    Country:Viet Nam  

  • Creation of a non-invasive malaria vaccine and elucidation of the immune mechanism International conference

    Keisuke Tanaka, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    ACB2023  2023.10 

     More details

    Event date: 2023.10

    Language:English  

    Country:Viet Nam  

  • 人工脂質化タンパク質の脂質膜上での動態評価

    内田和希, 若林里衣, 後藤雅宏, 下川直史, 高木昌宏, 神谷典穂

    「細胞を創る」研究会16.0  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:東京大学  

  • 免疫細胞への抗原送達における抗原修飾ペプチド共集合体の表面電荷の影響

    難波江友紀、樋口亜也斗、若林里衣、神谷典穂、後藤雅宏

    学術変革A「超越分子システム」第二回若手会  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:大阪公立大学 I-siteなんば  

  • タンパク質の事後修飾が可能な酵素反応性ペプチド集合体を用いたエマルション型ワクチンの創製

    樋口亜也斗・若林里衣・後藤雅宏・神谷典穂

    学術変革A「超越分子システム」第3回領域会議  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:高野山大学  

  • 免疫細胞の活性化に抗原修飾両親媒性ペプチド集合体の分子設計が及ぼす影響

    山口恭平・若林里衣・神谷典穂・後藤雅宏

    学術変革A 「超越分子システム」 第3回領域会議@高野山  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:高野山大学  

  • mRNA医薬の経皮送達を目的としたイオン液体製剤の開発

    東智大、豊福淳大、若林里衣、神谷憲穂、後藤雅宏

    化学工学第54回秋季大会  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:福岡大学  

  • 非侵襲的な糖尿病治療を目指した経皮GLP-1RA製剤の開発

    松尾碧湖、若林里衣、神谷典穂、後藤雅宏

    化工秋季大会  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:福岡大学七隈キャンパス  

  • イオン液体を用いた抗体医薬の新規経皮製剤の創成

    藏薗俊介・若林里衣・神谷典穂・後藤雅宏

    化学工学会第54回秋季大会  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:福岡大学 七隈キャンパス  

  • アルキル鎖の長鎖化による脂質修飾タンパク質のダイナミクスの変化

    内田和希, 若林里衣, 後藤雅宏, 下川直史, 高木昌宏, 神谷典穂

    化学工学会第54回秋季大会  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡大学  

  • 生体適合性イオン液体を用いたSolid-in-Oil製剤によるアンチセンス核酸の経皮・細胞内送達

    豊福淳大、若林里衣、神谷典穂、後藤雅宏

    化学工学会第54回秋季大会  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:福岡大学 七隈キャンパス  

  • 経皮マラリアワクチンの創製および投与形態が 免疫応答へ与える影響評価

    田中 敬佑、南畑 孝介、若林 里衣、神谷 典穂、後藤 雅宏

    化学工学会第54回秋季大会  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:福岡大学  

  • 経皮マラリアワクチンにおける免疫応答解析

    田中 敬佑、南畑 孝介、若林 里衣、神谷 典穂、後藤 雅宏

    第17回バイオ関連化学シンポジウム  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:東京理科大学野田キャンパス薬学部  

  • 静電相互作用を駆動力としたストレプトアビジン-ssDNAハイブリッド結晶形成に与える正電荷の影響

    長谷彩沙、南畑孝介、若林里衣、後藤雅宏、神谷典穂

    バイオ関連化学シンポジウム  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:千葉  

  • 酵素反応性ペプチド共集合体の表面電荷がもたらす免疫細胞への取り込みの影響

    難波江友紀、樋口亜也斗、若林里衣、神谷典穂、後藤雅宏

    第17回バイオ関連化学シンポジウム  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:東京理科大学野田キャンパス薬学部  

  • 抗原修飾ペプチド集合体のアルキル鎖長が免疫細胞の活性化に及ぼす影響

    山口恭平・若林里衣・神谷典穂・後藤雅宏

    第17回バイオ関連シンポジウム  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:東京理科大学野田キャンパス薬学部  

  • 脂質修飾タンパク質のアルキル鎖長が膜ダイナミクスに与える影響

    内田和希, 若林里衣, 後藤雅宏, 下川直史, 高木昌宏, 神谷典穂

    第17回バイオ関連化学シンポジウム  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:東京理科大学  

  • 脂質修飾タンパク質のアルキル鎖長が膜ダイナミクスに与える影響

    内田和希, 若林里衣, 後藤雅宏, 下川直史, 高木昌宏, 神谷典穂

    第10回バイオ関連化学シンポジウム若手フォーラム  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese  

    Venue:東京大学  

  • アルキル鎖長が異なる脂質修飾タンパク質の脂質二分子膜上での動態

    内田和希, 若林里衣, 後藤雅宏, 下川直史, 高木昌宏, 神谷典穂

    第75回日本生物工学会大会  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋大学  

  • 酵素反応によるペプチド集合体へのタンパク質修飾とエマルション型ワクチンへの展開

    樋口亜也斗・若林里衣・後藤雅宏・神谷典穂

    第17回バイオ関連化学シンポジウム  2023.9 

     More details

    Event date: 2023.8 - 2023.10

    Language:Japanese  

    Venue:東京理科大学野田キャンパス薬学部  

  • 抗原タンパク質修飾ペプチドファイバーのワクチン応用

    樋口亜也斗・若林里衣・後藤雅宏・神谷典穂

    第39回日本DDS学会学術集会  2023.7 

     More details

    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:幕張メッセ 国際会議場  

  • 生体適合性イオン液体を用いた核酸医薬の非侵襲的経皮デリバリー

    豊福淳大、若林里衣、神谷典穂、後藤雅宏

    第39回DDS学会  2023.7 

     More details

    Event date: 2023.7

    Language:Japanese  

    Venue:幕張メッセ国際会議場  

  • 経皮インフルエンザワクチンの創製

    田中 敬佑、真崎 菜月、南畑 孝介、若林 里衣、神谷 典穂、後藤 雅宏

    第39回日本DDS学会学術集会  2023.7 

     More details

    Event date: 2023.7

    Language:Japanese  

    Venue:幕張メッセ 国際会議場  

  • 経皮マラリアワクチンの創製及び投与形態による免疫応答性の評価

    田中 敬佑、若林 里衣、神谷 典穂、後藤 雅宏

    第34回生体機能関連化学部会若手の会 サマースクール  2023.7 

     More details

    Event date: 2023.7

    Language:Japanese  

    Venue:あいち健康の森プラザホテル  

  • 酵素反応性自己組織化ペプチドに基づくエマルション型ワクチンの創製

    樋口亜也斗・若林里衣・後藤雅宏・神谷典穂

    第34回生体機能関連化学部会若手の会 サマースクール  2023.7 

     More details

    Event date: 2023.7

    Language:Japanese  

    Venue:あいち健康の森プラザホテル  

  • 新規イオン液体ナノ粒子製剤の開発と核酸医薬の経皮・細胞内DDS

    豊福淳大、若林里衣、神谷典穂、後藤雅宏

    第34回生体機能関連化学部会若手の会 サマースクール  2023.7 

     More details

    Event date: 2023.7

    Language:Japanese  

    Venue:あいち健康の森プラザホテル  

  • イオン液体を用いたmRNA医薬の経皮送達

    東智大、豊福淳大、若林里衣、神谷憲穂、後藤雅宏

    第33回九州地区若手ケミカルエンジニア討論会  2023.7 

     More details

    Event date: 2023.7

    Language:Japanese  

    Venue:鹿児島大学  

  • 酵素反応性ペプチド共集合体を用いたワクチンアジュバントの創製

    難波江友紀、樋口亜也斗、若林里衣、神谷典穂、後藤雅宏

    第33回九州地区若手ケミカルエンジニア討論会  2023.7 

     More details

    Event date: 2023.7

    Language:Japanese  

    Venue:鹿児島大学  

  • Creation of transdermal malaria vaccine and analysis of immune response International conference

    Keisuke Tanaka, Kosuke Minamihata, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    YABEC 2023 Symposium  2023.7 

     More details

    Event date: 2023.7

    Language:English  

    Country:Taiwan, Province of China  

  • Lipid moieties affect the dynamics of lipid-modified proteins on lipid membranes International conference

    Kazuki Uchida, Rie Wakabayashi, Masahiro Goto, Naofumi Shimokawa, Masahiro Takagi, Noriho Kamiya

    2023 BEST Joint YABEC International Symposium  2023.7 

     More details

    Event date: 2023.7

    Language:English  

    Country:Taiwan, Province of China  

  • mRNA医薬の経皮製剤化を目的としたイオン液体製剤の開発

    東智大、豊福淳大、若林里衣、神谷憲穂、後藤雅宏

    第60回化学関連支部合同九州大会  2023.7 

     More details

    Event date: 2023.7

    Language:Japanese  

    Venue:北九州  

  • 酵素反応性ペプチド共集合体を用いたワクチンアジュバントの開発

    難波江友紀、樋口亜也斗、若林里衣、神谷典穂、後藤雅宏

    第60回化学関連支部合同九州大会  2023.7 

     More details

    Event date: 2023.7

    Language:Japanese  

    Venue:北九州国際会議場  

  • 脂質修飾タンパク質のアルキル鎖長が膜上のダイナミクスに及ぼす影響

    内田和希, 若林里衣, 後藤雅宏, 下川直史, 高木昌宏, 神谷典穂

    生物工学若手研究者の集い 夏のセミナー  2023.6 

     More details

    Event date: 2023.6

    Language:Japanese  

    Venue:砺波青少年自然の家  

  • 酵素反応性自己組織化ペプチドを用いたO/Wエマルションの創製

    樋口 亜也斗, 若林 里衣, 後藤 雅宏, 神谷 典穂

    日本化学会第103回春季年会2023,  2023.3 

     More details

    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京理科大学   Country:Japan  

  • 表面電荷を制御した酵素反応性ペプチド共集合体の創製

    難波江 友紀, 樋口 亜也斗, 若林 里衣, 神谷 典穂, 後藤 雅宏

    日本化学会第103回春季年会2023,  2023.3 

     More details

    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京理科大学   Country:Japan  

  • Fabrication of emulsion vaccine using enzymatic reactivity supramolecular fiber International conference

    Ayato Higuchi, Rie Wakabayashi, Noriho Kamiya, and Masahiro Goto

    YABEC2023  2022.12 

     More details

    Event date: 2022.12

    Language:English  

    Country:Indonesia  

  • ペプチドファイバーを用いた免疫細胞の活性化

    山口 恭平, 若林 里衣, 神谷 典穂, 後藤 雅宏

    第8回九州地区大学-高専若手研究者研究・教育セミナー  2022.11 

     More details

    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島大学   Country:Japan  

  • O/Wエマルション作製に向けた界面安定化ペプチドファイバーの設計探索

    樋口 亜也斗, 若林 里衣, 後藤 雅宏, 神谷 典穂

    第8回九州地区大学-高専若手研究者研究・教育セミナー  2022.11 

     More details

    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島大学   Country:Japan  

  • Hierarchical co-assembly with peptide amphiphiles promotes the non-endocytic delivery of small molecules into membrane-rich organelles International conference

    Hiroki Obayashi, Rie Wakabayashi, Noriho Kamiya, and Masahiro Goto

    The 15th Asian Congress on Biotechnology  2022.10 

     More details

    Event date: 2022.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Indonesia  

  • 免疫細胞の活性化を目指した抗原修飾両親媒性ペプチド集合体の創製

    山口 恭平, 若林 里衣, 鍔田 武志, 神谷 典穂, 後藤 雅宏

    化学工学会第53回秋季大会  2022.9 

     More details

    Event date: 2022.9

    Language:Japanese  

    Venue:信州大学   Country:Japan  

  • 免疫細胞の活性化に向けた抗原ペプチド集合体の創製

    山口 恭平, 若林 里衣, 神谷 典穂, 後藤 雅宏

    第16回バイオ関連シンポジウム  2022.9 

     More details

    Event date: 2022.9

    Language:Japanese  

    Venue:名古屋大学   Country:Japan  

  • 相補的な相互作用を介して形成された共集合体のエネルギー非依存的な脂質膜透過

    大林 洋貴, 若林 里衣, 神谷 典穂, 後藤 雅宏

    第16回バイオ関連シンポジウム  2022.9 

     More details

    Event date: 2022.9

    Language:Japanese  

    Venue:名古屋大学   Country:Japan  

  • 酵素反応性自己組織化ペプチドに基づくエマルション型ワクチンの創製

    樋口 亜也斗, 若林 里衣, 後藤 雅宏, 神谷 典穂

    第16回バイオ関連シンポジウム  2022.9 

     More details

    Event date: 2022.9

    Language:Japanese  

    Venue:名古屋大学   Country:Japan  

  • Co-assembly with peptide amphiphiles through complementary hydrogen bonding facilitates non-endocytic cellular internalization of small molecules International conference

    Hiroki Obayashi, Rie Wakabayashi, Noriho Kamiya, and Masahiro Goto

    APCChE 2022  2022.8 

     More details

    Event date: 2022.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Malaysia  

  • Control of enzymatic post-modification of self-assembled aromatic peptide amphiphiles using pH responsiveness International conference

    Ayato Higuchi, Rie Wakabayashi, Noriho Kamiya, and Masahiro Goto

    IUMRS-ICYRAM2022  2022.8 

     More details

    Event date: 2022.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Membrane-permeable hierarchical co-assemblies show direct cellular internalization with size-dependency International conference

    Hiroki Obayashi, Rie Wakabayashi, Noriho Kamiya, and Masahiro Goto

    IUMRS-ICYRAM2022  2022.8 

     More details

    Event date: 2022.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 抗原修飾ペプチド集合体の分子設計が免疫細胞の活性化に及ぼす影響

    山口恭平, 若林里衣, 神谷典穂, 後藤雅宏

    第32回九州地区若手ケミカルエンジニア討論会  2022.7 

     More details

    Event date: 2022.7

    Language:Japanese  

    Venue:福岡大学   Country:Japan  

  • 免疫細胞の活性制御を目指した抗原修飾両親媒性ペプチド集合体の創製

    山口恭平, 若林里衣, 神谷典穂, 後藤雅宏

    第59回化学関連支部合同九州大会  2022.7 

     More details

    Event date: 2022.7

    Language:Japanese  

    Venue:北九州国際会議場   Country:Japan  

  • 非エンドサイトーシス経路で細胞内へ移行可能なペプチド-小分子共集合キャリアの開発

    樋口亜也斗 若林里衣 神谷典穂 後藤雅宏

    第38回 日本DDS学会学術集会  2022.6 

     More details

    Event date: 2022.6

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 非エンドサイトーシス経路で細胞内へ移行可能なペプチド-小分子共集合キャリアの開発

    大林洋貴 若林里衣 神谷典穂 後藤雅宏

    第38回 日本DDS学会学術集会  2022.6 

     More details

    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 液液相分離環境下の超分子構造体の濃縮とタンパク質機能への影響

    大林洋貴 若林里衣 後藤雅宏 神谷典穂

    日本化学会 第102春季年会  2022.3 

     More details

    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 共集合を利用した自己組織化ペプチドの酵素反応性制御

    樋口亜也斗、若林里衣、後藤雅宏、神谷典穂

    日本化学会 第102春季年会  2022.3 

     More details

    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 酵素反応を利用した高分子・超分子ハイブリッドゲルの創製と機能化

    樋口亜也斗、若林里衣、後藤雅宏、神谷典穂

    化学工学会第87年会  2022.3 

     More details

    Event date: 2022.3

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 抗原修飾自己組織化ペプチドを用いた免疫細胞の活性制御

    山口恭平, 若林里衣, 神谷典穂, 後藤雅宏

    第24回化学工学会学生発表会  2022.3 

     More details

    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • Controlled co-assembly system for evaluating the effect of biomaterials shape on the cellular internalization International conference

    Hiroki Obayashi Rie Wakabayashi Noriho Kamiya Masahiro Goto

    PacificChem2021  2021.12 

     More details

    Event date: 2021.12

    Language:Japanese  

    Country:Japan  

  • Self-assembled peptide scaffolds for enzymatic display of biofunctional molecules International conference

    Ayato Higuchi, Rie Wakabayashi, Hiroki Obayashi, Masahiro Goto, Noriho Kamiya

    PacificChem2021  2021.12 

     More details

    Event date: 2021.12

    Language:Japanese  

    Country:Japan  

  • 酵素反応を用いた超分子・高分子複合ゲルの創製

    樋口亜也斗、若林里衣、後藤雅宏、神谷典穂

    バイオマテリアル学会 九州地区講演会  2021.12 

     More details

    Event date: 2021.12

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • ペプチド共集合体システムによるナノ構造体の創製と細胞との相互作用

    中村 光児、大林 洋貴、若林 里衣、神谷 典穂、後藤 雅宏

    第31回九州地区若手ケミカルエンジニア討論会/第7回九州地区大学-高専若手研究者セミナー合同大会  2021.11 

     More details

    Event date: 2021.11

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 液-液相分離環境下の超分子構造体の相選択性と酵素反応制御

    大林洋貴 若林里衣 後藤雅宏 神谷典穂

    第15回バイオ関連化学シンポジウム  2021.9 

     More details

    Event date: 2021.9

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 酵素反応性を用いた両親媒性ペプチド集合体の事後修飾に及ぼす因子探索

    樋口亜也斗、若林里衣、後藤雅宏、神谷典穂

    第15回バイオ関連化学シンポジウム  2021.9 

     More details

    Event date: 2021.9

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • ペプチド共集合体システムによるナノ構造体と細胞作用

    中村 光児、大林 洋貴、若林 里衣、神谷 典穂、後藤 雅宏

    生体機能関連 第32回サマースクール  2021.7 

     More details

    Event date: 2021.7

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 酵素反応性自己組織化ペプチドによる事後修飾の pH 依存性

    樋口亜也斗、若林里衣、後藤雅宏、神谷典穂

    生体機能関連 第32回サマースクール  2021.7 

     More details

    Event date: 2021.7

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • ペプチド共集合体システムによるナノ構造体の形状制御と細胞作用

    中村 光児、大林 洋貴、若林 里衣、神谷 典穂、後藤 雅宏

    第58回化学関連支部合同九州大会  2021.7 

     More details

    Event date: 2021.7

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 細胞内デリバリーにおける形状依存性評価を志向したペプチド-蛍光小分子共集合体の開発

    大林洋貴、若林里衣、神谷典穂、後藤雅宏

    第37回日本DDS学会学術集会  2021.6 

     More details

    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:幕張メッセ国際会議場   Country:Japan  

  • ペプチド-小分子共集合体の構造制御と形状依存的な細胞内デリバリー

    大林洋貴、中村光児、若林里衣、神谷典穂、後藤雅宏

    化学工学会第86回年会  2021.3 

     More details

    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • pH に依存した両親媒性ペプチドの自己組織化と酵素反応的事後修飾

    樋口亜也斗、若林里衣、後藤雅宏、神谷典穂

    日本化学会第101春季年会  2021.3 

     More details

    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • ペプチド共集合体システムによるナノ構造体の形状制御と細胞内デリバリー

    中村 光児、大林 洋貴、若林 里衣、神谷 典穂、後藤 雅宏

    日本化学会第101春季年会  2021.3 

     More details

    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 両親媒性ペプチドとの相補的共集合化が促進する小分子の細胞内デリバリー

    大林洋貴、若林里衣、神谷典穂、後藤雅宏

    日本化学会第100春季年会  2020.3 

     More details

    Event date: 2020.3 - 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京理科大学   Country:Japan  

  • 自己組織化ペプチドの pH に依存した構造変化と酵素反応性

    樋口亜也斗、大林洋貴、若林里衣、後藤雅宏、神谷典穂

    日本化学会第100春季年会  2020.3 

     More details

    Event date: 2020.3 - 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京理科大学   Country:Japan  

  • 自己組織化の温度依存性を利用した両親媒性ペプチドの共集合制御

    今谷梨乃、若林里衣、神谷典穂、後藤雅宏

    日本化学会第100春季年会  2020.3 

     More details

    Event date: 2020.3 - 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京理科大学   Country:Japan  

  • 酵素触媒によるペプチド自己集合材料の事後機能化

    樋口亜也斗、大林洋貴、若林里衣、神谷典穂、後藤雅宏

    化学工学会第 85 年会  2020.3 

     More details

    Event date: 2020.3 - 2019.3

    Language:Japanese  

    Venue:関西大学   Country:Japan  

  • 酵素反応を利用した自己組織化ペプチドの事後修飾におけるpH 依存性

    樋口亜也斗、大林洋貴、若林里衣、神谷典穂、後藤雅宏

    第 22 回化学工学会学生発表会 (岡山大会)  2020.3 

     More details

    Event date: 2020.3 - 2019.3

    Language:Japanese  

    Venue:岡山大学   Country:Japan  

  • Development of peptide co-assemblies induced by complementary hydrogen bond for drug delivery application International conference

    Hiroki Obayashi, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    The 32nd International Symposium on Chemical Engineering  2019.12 

     More details

    Event date: 2019.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • 高効率に生体高分子を事後修飾可能な自己組織化ペプチド足場材料の創製

    樋口亜也斗、若林里衣、後藤雅宏、神谷典穂

    化学工学会九州支部オンライン学生発表会  2020.12 

     More details

    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • ペプチド-蛍光プローブ共集合体を用いた細胞内移行における形状依存性評価

    大林洋貴、若林里衣、神谷典穂、後藤雅宏

    第二回水圏若手スクール  2020.11 

     More details

    Event date: 2019.11

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • Development of peptide-drug co-assemblies induced by complementary interaction and their intracellular localization International conference

    Hiroki Obayashi, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    OKINAWA COLLOIDS 2019  2019.11 

     More details

    Event date: 2019.11

    Language:English  

    Country:Japan  

  • 酵素触媒によるペプチド自己集合材料の事後修飾

    樋口亜也斗、大林洋貴、若林里衣、後藤雅宏、神谷典穂

    化学工学会第51回秋季大会  2020.9 

     More details

    Event date: 2019.9

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 疎水性置換基の種類で変わる両親媒性ペプチドの集合挙動

    今谷 梨乃、若林里衣、神谷典穂、後藤雅宏

    第14回バイオ関連化学シンポジウム  2020.9 

     More details

    Event date: 2019.9

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • ペプチド-蛍光プローブ共集合体を用いた細胞内取り込みにおける形状依存性の評価

    大林洋貴、若林里衣、神谷典穂、後藤雅宏

    第14回バイオ関連化学シンポジウム  2020.9 

     More details

    Event date: 2019.9

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 自己組織化ペプチドの酵素反応性制御因子の探索

    樋口亜也斗、大林洋貴、若林里衣、後藤雅宏、神谷典穂

    第14回バイオ関連化学シンポジウム  2020.9 

     More details

    Event date: 2019.9

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 温度による両親媒性ペプチドの自己選別性の制御

    今谷梨乃、若林里衣、神谷典穂、後藤雅宏

    第13回バイオ関連化学シンポジウム  2019.9 

     More details

    Event date: 2019.9

    Language:Japanese  

    Venue:東北大学   Country:Japan  

  • 多重水素結合が誘起する新規ペプチド-小分子共集合体の創製と応用

    大林洋貴、若林里衣、神谷典穂、後藤雅宏

    第13回バイオ関連化学シンポジウム  2019.9 

     More details

    Event date: 2019.9

    Language:Japanese  

    Venue:東北大学   Country:Japan  

  • 薬物キャリアへの応用を志向したペプチド-小分子共集合体の創製

    大林洋貴、若林里衣、神谷典穂、後藤雅宏

    2019年度生物工学若手研究者の集い 夏のセミナー  2019.7 

     More details

    Event date: 2019.7

    Language:Japanese  

    Venue:琵琶湖国定公園白浜荘   Country:Japan  

  • 相補的な水素結合を駆動力としたペプチド共集合体の創製と応用

    大林洋貴、若林里衣、神谷典穂、後藤雅宏

    生体機能関連化学部会若手の会 第31回サマースクール  2019.7 

     More details

    Event date: 2019.7

    Language:Japanese  

    Venue:セミナーハウス(東京都八王子市)   Country:Japan  

  • 疎水性置換基を利用した複数種類の両親媒性ペプチドの共集合制御

    今谷梨乃, 大林洋貴, 若林里衣, 神谷典穂, 後藤雅宏

    日本化学会第99春季年会  2019.3 

     More details

    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:甲南大学   Country:Japan  

  • 両親媒性ペプチドとの相補的互作用によるがん細胞へのドラッグデリバリー

    大林洋貴, 若林里衣, 神谷典穂, 後藤雅宏

    日本化学会第99春季年会  2019.3 

     More details

    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:甲南大学   Country:Japan  

  • Development of two-component drug delivery carriers using complementary interaction

    2018.12 

     More details

    Event date: 2018.12

    Language:Japanese  

    Country:Japan  

  • Effect of amino acids for transcutaneous vaccine using Solid-in-Oil nanodispersion International conference

    A. Yamada, R. Wakabayashi, Y. Tahara, N. Kamiya, M. Goto

    The 31th International Symposium on Chemical Engineering  2018.12 

     More details

    Event date: 2018.12

    Language:English  

    Country:Thailand  

  • Creation of orderly co-assemblies consisted of peptide amphiphileand drugs through complementary interaction International conference

    H. Obayashi, R. Wakabayashi, N. Kamiya, M. Goto

    The 31th International Symposium on Chemical Engineering  2018.12 

     More details

    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  • 疎水性置換基の異なる両親媒性ペプチドの共集合制御

    今谷梨乃, 若林里衣, 後藤雅宏, 神谷典穂

    第21回化学工学会学生発表会(京都大会)  2019.3 

     More details

    Event date: 2018.3 - 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都大学   Country:Japan  

  • 異種混合分子集合システムを利用した小分子薬物キャリアの開発

    大林洋貴, 若林里衣, 後藤雅宏, 神谷典穂

    第20回化学工学会学生発表会(東広島大会)  2018.3 

     More details

    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島大学   Country:Japan  

  • Fabrication of supramolecular peptide assembly with multiple domains International conference

    M. Katsuya, R. Wakabayashi, N. Kamiya, M. Goto

    The 30th International Symposium on Chemical Engineering  2017.12 

     More details

    Event date: 2017.12

    Language:English  

    Country:Korea, Republic of  

  • 疎水部のミクロ相分離を利用した両親媒性ペプチドの集合体内局在化

    勝家睦洋、若林里衣、神谷典穂、後藤雅宏

    第11回バイオ関連化学シンポジウム  2017.9 

     More details

    Event date: 2017.9

    Language:Japanese  

    Venue:東京大学   Country:Japan  

  • Cancer vaccine by transcutaneous antigen-peptide delivery using solid-in-oil technique International conference

    M. Goto, M. Sakuragi, .Wakabayashi, N. Kamiya

    APCChE 2017  2017.8 

     More details

    Event date: 2017.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:China  

▼display all

MISC

  • Poly(ethylene glycol)-based biofunctional hydrogels mediated by peroxidase-catalyzed cross-linking reactions Reviewed

    Rie Wakabayashi, Wahyu Ramadhan, Kousuke Moriyama, Masahiro Goto, Noriho Kamiya

    Polymer Journal   2020.1

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1038/s41428-020-0344-7

  • イオン液体を活用した経皮ドラッグデリバリーシステム

    化学と工業   2019.3

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • イオン液体の経皮吸収促進効果を利用したドラッグデリバリーシステム

    膜   2018.5

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 生体関連分子から成る非対称集合システム

    化学と工業   2018.3

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 液-液相分離における超分子の相選択性とタンパク質の局在制御

    若林 里衣

    化学と工業   2023.2

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Solid-in-oil nanodispersions for transcutaneous immunotherapy of Japanese cedar pollinosis Reviewed

    Qingliang Kong, Momoko Kitaoka, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    Pharmaceutics   2020.3

     More details

    Language:English  

    DOI: 10.3390/pharmaceutics12030240

  • 共役系高分子を自在に並べる

    若林里衣, 竹林新二, 竹内正之

    現代化学   2008.1

     More details

    Language:Japanese  

▼display all

Industrial property rights

Patent   Number of applications: 2   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

  • THE SOCIETY OF POLYMER SCIENCE, JAPAN

  • THE SOCIETY OF CHEMICAL ENGINEERS, JAPAN

  • THE JAPANESE SOCIETY FOR BIOMATERIALS

  • THE CHEMICAL SOCIETY OF JAPAN

  • THE SOCIETY OF POLYMER SCIENCE, JAPAN

      More details

  • THE CHEMICAL SOCIETY OF JAPAN

      More details

  • THE JAPANESE SOCIETY FOR BIOMATERIALS

      More details

  • THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

      More details

  • THE SOCIETY OF CHEMICAL ENGINEERS, JAPAN

      More details

▼display all

Committee Memberships

  • 日本化学会バイオテクノロジー部会   幹事   Domestic

    2023.3 - 2025.2   

  • 社団法人日本化学会 バイオテクノロジー部会   幹事  

    2023.2 - Present   

      More details

    Committee type:Academic society

    researchmap

  • 「細胞を創る」研究会   評議員  

    2022.9 - 2024.9   

      More details

    Committee type:Academic society

    researchmap

  • 若手の会代表   若手の会代表   Domestic

    2021.3 - 2023.2   

  • 社団法人日本化学会 バイオテクノロジー部会   若手の会代表  

    2021.3 - 2023.2   

      More details

  • 幹事(若手の会代表)   幹事(若手の会代表)   Domestic

    2015.3 - 2016.2   

▼display all

Academic Activities

  • 実行委員

    第14回 CSJ化学フェスタ2024  ( タワーホール船堀 ) 2024.10

     More details

    Type:Competition, symposium, etc. 

  • 実行委員

    日本工学教育協会実行委員会  第72回年次大会  ( 九州大学 ) 2024.9

     More details

    Type:Competition, symposium, etc. 

  • 実行委員

    第13回 CSJ化学フェスタ2023  ( タワーホール船堀 ) 2023.10

     More details

    Type:Competition, symposium, etc. 

  • セッションオーガナイザー

    「細胞を創る」研究会 16.0  ( 東京大学駒場キャンパス ) 2023.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • プログラム編成委員

    日本化学会第102春季年会  ( 東京理科大学 ) 2023.3

     More details

    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2023

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:14

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • 実行委員 International contribution

    ( 九州大学 ) 2022.8

     More details

    Type:Competition, symposium, etc. 

  • 座長ならびに講演賞審査員

    第24回化学工学会学生発表会  ( オンライン ) 2022.3

     More details

    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2022

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:15

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • 幹事

    第16回“光”機到来!Qコロキウム  ( オンライン ) 2021.5

     More details

    Type:Competition, symposium, etc. 

  • 幹事

    第14回“光”機到来!Qコロキウム  ( オンライン ) 2021.3

     More details

    Type:Competition, symposium, etc. 

  • 座長ならびに講演賞審査員

    第23回化学工学会学生発表会  ( オンライン ) 2021.3

     More details

    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2021

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • 幹事

    第8回“光”機到来!Qコロキウム  ( オンライン ) 2020.10

     More details

    Type:Competition, symposium, etc. 

  • ポスター賞審査委員

    化学工学会第51回秋季大会  ( オンライン ) 2020.9

     More details

    Type:Competition, symposium, etc. 

  • 実行委員

    第14回バイオ関連化学シンポジウム  ( オンライン ) 2020.9 - 2019.9

     More details

    Type:Competition, symposium, etc. 

  • ポスター賞審査委員

    第14回バイオ関連化学シンポジウム  ( オンライン ) 2020.9 - 2019.9

     More details

    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2020

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:13

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • 座長 International contribution

    ( 札幌コンベンションセンター ) 2019.9

     More details

    Type:Competition, symposium, etc. 

  • ポスター賞審査委員

    第13回バイオ関連化学シンポジウム  ( 東北大学 ) 2019.9

     More details

    Type:Competition, symposium, etc. 

  • ポスター賞審査委員

    第56回化学関連支部合同九州大会  ( 北九州国際会議場 ) 2019.7

     More details

    Type:Competition, symposium, etc. 

  • 座長

    日本化学会第99春季年会  ( 甲南大学 ) 2019.3

     More details

    Type:Competition, symposium, etc. 

  • 座長

    化学工学会第84回年会  ( 芝浦工業大学 ) 2019.3

     More details

    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2019

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:10

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • シンポジウムオーガナイザー

    第50回化学工学会秋季大会  ( 鹿児島大学 ) 2018.9

     More details

    Type:Competition, symposium, etc. 

  • 座長

    第12回バイオ関連化学シンポジウム  ( 大阪大学 ) 2018.9

     More details

    Type:Competition, symposium, etc. 

  • ポスター賞審査委員

    第12回バイオ関連化学シンポジウム  ( 大阪大学 ) 2018.9

     More details

    Type:Competition, symposium, etc. 

  • 実行委員長

    第29回九州地区若手ケミカルエンジニア討論会  ( 阿蘇プラザホテル ) 2018.7

     More details

    Type:Competition, symposium, etc. 

    Number of participants:135

  • ポスター賞審査委員

    第55回化学関連支部合同九州大会  ( 北九州国際会議場 ) 2018.6

     More details

    Type:Competition, symposium, etc. 

  • 座長

    日本化学会第98春季年会  ( 日本大学 ) 2018.3

     More details

    Type:Competition, symposium, etc. 

  • 座長

    化学工学会第83回年会  ( 関西大学 ) 2018.3

     More details

    Type:Competition, symposium, etc. 

  • 座長

    第20回化学工学会学生発表会  ( 広島大学 ) 2018.3

     More details

    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2018

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • 座長 International contribution

    2017.12

     More details

    Type:Competition, symposium, etc. 

  • ポスター賞審査委員

    第49回化学工学会秋季大会  ( 名古屋大学 ) 2017.9

     More details

    Type:Competition, symposium, etc. 

  • ポスター賞審査委員

    第11回バイオ関連化学シンポジウム  ( 東京大学 ) 2017.9

     More details

    Type:Competition, symposium, etc. 

  • ポスター賞審査委員

    第54回化学関連支部合同九州大会  ( 北九州国際会議場 ) 2017.7

     More details

    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2017

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • ポスター賞審査委員

    第10回バイオ関連化学シンポジウム  ( 石川県立音楽堂 ) 2016.9

     More details

    Type:Competition, symposium, etc. 

  • ポスター賞取り纏め

    第3回バイオ関連化学シンポジウム  ( 熊本大学 ) 2015.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:450

  • 世話人

    第3回バイオ関連化学シンポジウム若手フォーラム  ( 熊本大学 ) 2015.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:106

▼display all

Research Projects

  • Creation of non-invasive vaccines based on nanocoating technology of biomolecule

    Grant number:24H00397  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

      More details

    Grant type:Scientific research funding

    CiNii Research

  • 自己投与型ペプチドワクチンデバイスの開発

    2024

      More details

    Grant type:Donation

  • 超分子を活用した水性二相系での酵素濃縮による超活性場の創出

    Grant number:23K17849  2023 - 2024

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

    若林 里衣

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

    水系溶媒中で液-液相分離しドロップレットを形成する水性二相分離は、物質の自由な出入りが可能な相分離系である。本研究では、このドロップレット中に自己組織化ペプチドが形成する超分子がサイズ依存的に局在するという研究代表者が見出した現象を活用し、酵素超活性場の創出を目指す。まず、様々な超分子を調製し、ドロップレット内に局在可能な超分子の構造的性質を調べる。続いて外部刺激依存的に超分子へ酵素を吸着させる。連続反応を触媒するカスケード酵素を集積化することで、液-液相分離における超分子の局在と超分子への酵素吸着による局所濃縮効果を用いた超活性の発現が可能かどうか評価を行う。

    CiNii Research

  • 膜透過性を示す超分子の構造因子の解明

    2023

      More details

    Grant type:Donation

  • Exploring New Fields in Drug Delivery Systems Using Ionic Liquids

    Grant number:22K18314  2022.6 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Pioneering)

      More details

    Grant type:Scientific research funding

    CiNii Research

  • Development of vaccine adjuvant based on peptidic supramolecules loaded with antigenic proteins

    Grant number:23K23152  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Grant type:Scientific research funding

    CiNii Research

  • 抗原を直接担持可能なペプチド超分子を基盤としたワクチンアジュバントの創製

    Grant number:22H01884  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • Aquatic peptide supramolecules with controlled molecular distributions and their hydrated structures and cellular functions

    Grant number:22H04552  2022 - 2023

    Japan Society for the Promotion of Science・Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

    CiNii Research

  • 第16回(2021年度) 内藤記念女性研究者研究助成金/抗原分子で表面修飾可能なペプチドエマルション型ワクチンの創製

    2022

      More details

    Grant type:Donation

  • 完全再構成型ウイルス・細菌様粒子のボトムアップ構築

    Grant number:21H05227  2021.9 - 2026.3

    科学研究費助成事業  学術変革領域研究(A)

    堀 克敏, 浦野 諒, 若林 里衣

      More details

    Grant type:Scientific research funding

    ウイルスも細菌細胞も、自然が創り出した精巧な分子システムである。本研究では、ウイルス様粒子と細菌様粒子を、バイオ分子と人工材料から計算科学も駆使しながらボトムアップ構築する。相互作用を生み出す分子の時空間的配置を制御して分子システムを構築する方法論を示す。ナノ空間とミクロ空間比較により、スケールをまたいで構造の複雑化と秩序形成が起こる機構を解明、制御し、超越分子システムを構築する学理を導く。

    CiNii Research

  • Creation of Non-Invasive Transdermal Vaccine Using Solid-in-Oil Nano-dispersion Technique

    Grant number:21H04631  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

      More details

    Grant type:Scientific research funding

    CiNii Research

  • 第35回ノバルティス研究奨励金/ペプチドエマルションのアジュバント効果の検証

    2021

      More details

    Grant type:Donation

  • 第16回(2021年度) 内藤記念女性研究者研究助成金/抗原分子で表面修飾可能なペプチドエマルション型ワクチンの創製

    2021

      More details

    Grant type:Donation

  • 上原記念生命科学財団 2021年度研究助成金/超分子ファイバーを基盤としたワクチンの物性と免疫

    2021

      More details

    Grant type:Donation

  • 第53回倉田奨励金/細胞膜に作用する超分子の創製と機構解明

    2021

      More details

    Grant type:Donation

  • 環境応答型の分子分布を持つ水圏機能ペプチド材料の創製

    Grant number:20H05229  2020 - 2021

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

    若林 里衣

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

    本研究は、複数種類の両親媒性ペプチド (PA) からなる多機能化材料において、環境に応答して分子分布をスイッチ可能な水圏機能ペプチド材料の創製を目指している。基盤となるPA分子には、互いに独立して組織化、すなわち自己選別的な集合体を形成するPAペアを用いる。これに対し、双方のPA分子に親和性のあるドーパント分子を導入することで、PAペア間の相溶性を変化させ分子分布を調整する。さらにドーパント分子に環境応答性を付与し、環境に応じた分子分布の変調を達成する。PAに細胞接着性配列を導入し、PAの分子分布に起因した細胞接着性の変調が達成可能かを検証する。

    CiNii Research

  • 池谷科学技術振興財団 2020年度研究助成 生体分子で表面修飾可能な次世代エマルション製剤の開発

    2020

      More details

    Grant type:Donation

  • 稲盛財団 2020年度稲盛研究助成 ペプチド性超分子の物理的因子と細胞作用

    2020

      More details

    Grant type:Donation

  • 資生堂 第13回資生堂女性研究者サイエンスグラント 高機能エマルション製剤の創製に向けた自己組織化ペプチドの活用

    2020

      More details

    Grant type:Donation

  • Exploring the novel properties of proteins by controlling the partial hydrophobicity

    Grant number:19H00841  2019 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Kamiya Noriho

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

    The amphiphilic nature of lipids is critical to form cellular compartments for the maintenance of biological activities by spontaneously building up lipid bilayers. In this study, we focused on the involvement of natural proteins in various biological events on lipid-bilayer membranes by acquiring partial hydrophobicity by the lipid modification. To explore the potential of partial hydrophobicity introduced through artificial lipid modification, we conducted basic research from biochemical, biophysical and bioengineering viewpoints such as protein engineering of enzymes that catalyze cross-linking of heterologous biomolecules, behavior of lipid-modified proteins on lipid bilayers and biomolecular engineering of antifungal enzymes. We also explored potential application of artificial lipid-modified proteins to lipid-based drug delivery systems.

    CiNii Research

  • イオン液体を利用した創薬研究における新分野開拓

    Grant number:19H05518  2019 - 2021

    日本学術振興会  科学研究費助成事業  挑戦的研究(開拓)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 2019年度 豊田理研スカラー

    2019

      More details

    Grant type:Donation

  • 異種ドメイン連結型バイオコンジュゲーションによる細胞表層機能材料の開発

    Grant number:18K04855  2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    若林 里衣

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

    細胞膜上の複数種類の膜タンパク質を機能的に連携することは、細胞機能の向上や制御に繋がる。本研究は、膜タンパク質に作用する複数種類の生体分子を一つの構造体上に、各々の分子局在を制御した上で集積可能な「集積化バイオコンジュゲーション」技術の開発を目指した。そのために、生体分子の足場となる構造形成と生体分子の機能化法を中心に研究を進めた。結果、疎水部に非相溶性の置換基を持つ両親媒性ペプチド (PA) の設計と自己組織化条件検討により、ドメイン構造を持つ構造体の形成が可能であることを示した。また酵素反応とavidin-biotin相互作用により、生体分子をPA集合体上に修飾可能であることを示した。

    CiNii Research

  • 抗原分子の油状ナノ分散化技術を利用した低侵襲性経皮ワクチンの創製

    2016 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(S)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • タンパク質を構成要素とする超分子型自己集合系の構築と高次機能の創出

    2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 新規ヘテロ接合型分子集合体の創製による自己集合材料の新しい機能化法の提案

    Grant number:15K18277  2015 - 2017

    科学研究費助成事業  若手研究(B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 第4回新化学技術研究奨励賞/機能性生体分子の酵素触媒的修飾を可能とする自己集合足場のナノデザイン

    2015

      More details

    Grant type:Donation

  • 基礎科学研究助成、多層ナノキャリアへの核移行シグナル分子の導入による高効率遺伝子デリバリー

    2014

      More details

    Grant type:Donation

  • 第54回学術奨励賞、生体触媒による分子集合体の階層構造制御

    2014

      More details

    Grant type:Donation

  • 笹川科学研究助成、両親媒性ペプチド分子の静的・動的自己集合制御と生体材料としての機能発現

    2013

      More details

    Grant type:Donation

  • イオン液体を利用した創薬研究における新分野開拓

    Grant number:20K20440 

    後藤 雅宏, 田原 義朗, 原田 耕志, 若林 里衣

      More details

    Grant type:Scientific research funding

    本研究では、イオン液体を用いた創薬研究に“生体適合イオン液体の創生”というブレイクスルーを生み出し、イオン液体の世界に“薬物応用”という新しい研究領域を開拓することに挑戦する。イオン液体の創薬応用においては、臨床レベルでイオン液体が利用された例は少なく、研究領域として大きく発展するまでには至っていない。その最大のポイントは生体適合性のイオン液体創生にある。そこで本研究では、生体適合性のイオン液体開発を行い医工連携を通して、これまでの製剤技術の体系や方向性を大きく変革するようなイオン液体研究にチャレンジする。

    CiNii Research

▼display all

Class subject

  • 物理化学演習

    2023.12 - 2024.2   Winter quarter

  • 生体分子工学

    2023.10 - 2024.3   Second semester

  • 物質科学工学実験第一

    2023.10 - 2024.3   Second semester

  • 基礎化学熱力学II

    2023.6 - 2023.8   Summer quarter

  • 物質科学コミュニケーション第二

    2023.4 - 2024.3   Full year

  • 物質科学学生セミナー第二

    2023.4 - 2024.3   Full year

  • 物理化学演習

    2022.12 - 2023.2   Winter quarter

  • 物質科学工学実験第一

    2022.10 - 2023.3   Second semester

  • 物質科学工学実験第三

    2022.10 - 2023.3   Second semester

  • 物質科学コミュニケーション第二

    2022.4 - 2023.3   Full year

  • 物質科学学生セミナー第二

    2022.4 - 2023.3   Full year

  • 物理化学演習

    2021.12 - 2022.2   Winter quarter

  • 物質科学工学実験第一

    2021.10 - 2022.3   Second semester

  • 物質科学コミュニケーション第二

    2021.4 - 2022.3   Full year

  • 物質科学学生セミナー第二

    2021.4 - 2022.3   Full year

  • 物理化学演習

    2020.12 - 2021.2   Winter quarter

  • 物質科学工学実験第一

    2020.10 - 2021.3   Second semester

  • 物質科学コミュニケーション第二

    2020.4 - 2021.3   Full year

  • 物質科学学生セミナー第二

    2020.4 - 2021.3   Full year

  • 物理化学演習

    2019.12 - 2020.2   Winter quarter

  • 物質科学工学実験第三

    2019.10 - 2020.3   Second semester

  • 物質科学コミュニケーション第二

    2019.4 - 2020.3   Full year

  • 物質科学学生セミナー第二

    2019.4 - 2020.3   Full year

  • 物質科学工学実験第三

    2018.10 - 2019.3   Second semester

  • 物質科学コミュニケーション第二

    2018.4 - 2019.3   Full year

  • 物質科学学生セミナー第二

    2018.4 - 2019.3   Full year

  • 物質科学工学概論第二

    2018.4 - 2018.9   First semester

  • 物理化学演習

    2018.4 - 2018.9   First semester

  • 物質科学工学実験第三

    2017.10 - 2018.3   Second semester

  • 物質科学コミュニケーション第二

    2017.4 - 2018.3   Full year

  • 物質科学学生セミナー第二

    2017.4 - 2018.3   Full year

  • 物質科学工学概論第二

    2017.4 - 2017.9   First semester

  • 物理化学演習

    2017.4 - 2017.9   First semester

  • 物質科学工学実験第三

    2016.10 - 2017.3   Second semester

  • 物質科学コミュニケーション第二

    2016.4 - 2017.3   Full year

  • 物質科学学生セミナー第二

    2016.4 - 2017.3   Full year

  • 物質科学工学概論第二

    2016.4 - 2016.9   First semester

  • 物理化学演習

    2016.4 - 2016.9   First semester

  • 物質科学工学実験第三

    2015.10 - 2016.3   Second semester

  • 物質科学学生セミナー第二

    2015.4 - 2016.3   Full year

  • 物質科学コミュニケーション第二

    2015.4 - 2016.3   Full year

  • 物質科学工学概論第二

    2015.4 - 2015.9   First semester

  • 物理化学演習

    2015.4 - 2015.9   First semester

  • 物質科学工学実験第三

    2014.10 - 2015.3   Second semester

  • 物質科学学生セミナー第二

    2014.4 - 2015.3   Full year

  • 物質科学コミュニケーション第二

    2014.4 - 2015.3   Full year

  • 物質科学工学概論第二

    2014.4 - 2014.9   First semester

  • 物理化学演習

    2014.4 - 2014.9   First semester

  • 物質科学工学実験第三

    2013.10 - 2014.3   Second semester

  • 物質科学学生セミナー第二

    2013.4 - 2014.3   Full year

  • 物質科学コミュニケーション第二

    2013.4 - 2014.3   Full year

  • 物質科学工学概論第二

    2013.4 - 2013.9   First semester

  • 物質科学工学実験第三

    2012.10 - 2013.3   Second semester

  • 物質科学コミュニケーション第二

    2012.4 - 2013.3   Full year

  • 物質科学学生セミナー第二

    2012.4 - 2013.3   Full year

  • 物質科学工学概論第二

    2012.4 - 2012.9   First semester

▼display all

FD Participation

  • 2023.11   Role:Participation   Title:GakuNin RDMデータ活用セミナー : これからの研究データ管理を探る

    Organizer:University-wide

  • 2021.3   Role:Participation   Title:学習支援システム(M2B)講習会(オンライン開催)◇初級編・中・上級編◇

    Organizer:University-wide

  • 2020.5   Role:Participation   Title:オンサイト授業 vs. オンライン授業:分かったこと,変わったこと

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.1   Role:Participation   Title:研究分析ツール「SciVal」および研究者プロファイリングツール「Pure」に関する説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.10   Role:Participation   Title:九州大学における男女共同参画の取り組み

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.1   Role:Participation   Title:東京工業大学の教育改革

    Organizer:University-wide

  • 2014.12   Role:Participation   Title:「米国西海岸シリコンバレーにおける工学英語研修」における講師による講習

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2013.11   Role:Participation   Title:著作権と機関リポジトリ 〜博士論文のインターネット公表に関連して〜

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2013.6   Role:Participation   Title:平成25年度第1回工学部(府)FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.4   Role:Participation   Title:新任教員の研修

    Organizer:University-wide

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2022  Faculty of Fisheries and Marine Sciences, IPB University, Indonesia  Classification:Part-time lecturer  Domestic/International Classification:Overseas 

    Semester, Day Time or Duration:May 2022-July 2022

Other educational activity and Special note

  • 2024  Class Teacher 

  • 2023  Class Teacher 

Outline of Social Contribution and International Cooperation activities

  • Guidance of experimental class in Kyushu University open campus for high school students.

Social Activities

  • 光で楽しむ化学

    ピカリかがく  福岡舞鶴高校  2023.11

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Other

  • サイエンスカフェ

    ピカリかがく  九大伊都蔦屋書店  2023.11

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 九州大学オープンキャンパス

    九州大学  九州大学 伊都キャンパス  2023.8

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Other

  • 九州大学オープンキャンパス

    九州大学  九州大学 伊都キャンパス  2017.8

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Other

  • 九州大学オープンキャンパス

    九州大学  九州大学 伊都キャンパス  2015.8

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Other

  • 九州大学オープンキャンパス

    九州大学  九州大学 伊都キャンパス  2014.8

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Other

▼display all