MURATA ASAKO
Organization
Faculty of Engineering Sciences Department of Advanced Materials Science and Engineering Associate Professor
Interdisciplinary Graduate School of Engineering Sciences Department of Interdisciplinary Engineering Sciences（Joint Appointment）
Title
Associate Professor
Contact information
Tel
0925838845
Profile
We are working at the interface of chemistry and biology, exploring small molecules that can bind to nucleic acids (DNAs and RNAs) and modulate their functions.
Homepage
-
https://igses.kyushu-u.ac.jp/murata/en/about-us/
Interdisciplinary Graduate School of Engineering Sciences (IGSES), Biomolecular function chemistry group
External link
ORCID
Degree
-
Ph.D. (Life science)
Research History
-
ベイラー医科大学 生化学・分子生物学科 博士研究員（2006.6–2008.2） 京都大学 化学研究所 特任研究員（2008.3–2010.2） 京都大学 物質-細胞統合システム拠点（iCeMS）研究員（2010.3） 京都大学 物質-細胞統合システム拠点（iCeMS）特定研究員（2010.4–2010.6） 大阪大学 産業科学研究所 特任研究員（2010.6–2012.11） 大阪大学 産業科学研究所 助教（2012.12–2019.12） 大阪大学 産業科学研究所 准教授（2019.12–2022.3）
Research Interests・Research Keywords
-
Research theme：● Development of a method for identifying RNA sequence-structural motifs for small-molecule binding ● Analysis of big data of small molecule-RNA binding pairs for rational design of a small molecule binding to target RNA ● Development of a prediction model of small molecule-RNA binding pairs.
Keyword：RNA, small molecule, RNA structure, Comprehensive analysis, Big data, Data analysis, Machine learning
Research period： 2021.4
-
Research theme：●Elucidation of the novel RNA secondary structure induced by a small molecule
Keyword：RNA, Small molecule, RNA structure, RNA-small molecule complex, Structure analysis
Research period： 2021.4
-
Research theme：●Screening of chemical libraries for a small molecule targeting the frameshifting signal of an RNA virus
Keyword：RNA virus, −1 ribosomal frameshifting, Small molecule, Compound screening
Research period： 2020.4
-
Research theme：●Small molecule-induced −1 ribosomal frameshifting and its application to control protein transport/localization
Keyword：−1 ribosomal frameshifting, Small molecule, Protein localization and transport
Research period： 2015.4 - 2021.3
-
Research theme：●Modulation of pre-miRNA processing by a small-molecule
Keyword：miRNA, Small molecule, Cleavage, Dicer, miRNA biogenesis, pre-miRNA processing
Research period： 2011.4 - 2022.3
-
Research theme：●Screening of a large chemical library for the identification of a small molecule that can bind to the target pre-miRNAs by using the fluorescence displacement assay
Keyword：Screening, Small molecule, Chemical library, pre-miRNA, Fluorescence displacement assay
Research period： 2010.5 - 2015.3
Papers
-
Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding International journal
Yusuke Takashima, Asako Murata, Kei Iida, Ayako Sugai, Masatoshi Hagiwara, Kazuhiko Nakatani
ACS CHEMICAL BIOLOGY 17 ( 10 ) 2817 - 2827 2022.9
-
Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit Reviewed International journal
Hsiu-Ting Hsu, Asako Murata, Chikara Dohno, Kazuhiko Nakatani, KungYao Chang
NUCLEIC ACIDS RESEARCH 50 ( 9 ) 5369 - 5383 2022.5
-
A small-molecule fluorescence probe ANP77 for sensing RNA internal loop of C, U and A/CC motifs and their binding molecules Reviewed International journal
Bimolendu Das, Asako Murata, Kazuhiko Nakatani
Nucleic Acids Research 49 ( 15 ) 8462 - 8470 2021.9
-
Small Molecule-Induced Dimerization of Hairpin RNA Interfered with the Dicer Cleavage Reaction. Reviewed International journal
Asako Murata, Yuki Mori, Yue Di, Ayako Sugai, Bimolendu Das, Yusuke Takashima, Kazuhiko Nakatani
Biochemistry 60 ( 4 ) 245 - 249 2021.2
-
A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo. Reviewed International journal
Masayuki Nakamori, Gagan B Panigrahi, Stella Lanni, Terence Gall-Duncan, Hideki Hayakawa, Hana Tanaka, Jennifer Luo, Takahiro Otabe, Jinxing Li, Akihiro Sakata, Marie-Christine Caron, Niraj Joshi, Tanya Prasolava, Karen Chiang, Jean-Yves Masson, Marc S Wold, Xiaoxiao Wang, Marietta Y W T Lee, John Huddleston, Katherine M Munson, Scott Davidson, Mehdi Layeghifard, Lisa-Monique Edward, Richard Gallon, Mauro Santibanez-Koref, Asako Murata, Masanori P Takahashi, Evan E Eichler, Adam Shlien, Kazuhiko Nakatani, Hideki Mochizuki, Christopher E Pearson
Nature genetics 52 ( 2 ) 146 - 159 2020.2
-
Modulating RNA secondary and tertiary structures by mismatch binding ligands Invited Reviewed International journal
Murata Asako, Nakamori Masayuki, Nakatani Kazuhiko
METHODS 167 78 - 91 2019.9
-
Inhibition of pre-miRNA-136 processing by Dicer with small molecule BzDANP suggested the formation of ternary complex of pre-miR-136-BzDANP-Dicer Reviewed International journal
Otabe Takahiro, Nagano Konami, Kawai Gota, Murata Asako, Nakatani Kazuhiko
BIOORGANIC & MEDICINAL CHEMISTRY 27 ( 10 ) 2140 - 2148 2019.5
-
Small synthetic molecule-stabilized RNA pseudoknot as an activator for-1 ribosomal frameshifting Reviewed International journal
Matsumoto Saki, Caliskan Neva, Rodnina Marina V, Murata Asako, Nakatani Kazuhiko
NUCLEIC ACIDS RESEARCH 46 ( 16 ) 8079 - 8089 2018.9
-
BzDANP, a Small-Molecule Modulator of Pre-miR-29a Maturation by Dicer Reviewed International journal
Asako Murata, Takahiro Otabe, Jinhua Zhang, Kazuhiko Nakatani
ACS CHEMICAL BIOLOGY 11 ( 10 ) 2790 - 2796 2016.10
-
Exploratory Study on the RNA-Binding Structural Motifs by Library Screening Targeting pre-miRNA-29a Reviewed International journal
Takeo Fukuzumi, Asako Murata, Haruo Aikawa, Yasue Harada, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL 21 ( 47 ) 16859 - 16867 2015.11
-
Live-Cell Imaging of Endogenous mRNAs with a Small Molecule Reviewed International journal
Shin-ichi Sato, Mizuki Watanabe, Yousuke Katsuda, Asako Murata, Dan Ohtan Wang, Motonari Uesugi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54 ( 6 ) 1855 - 1858 2015.2
-
A Chemical Probe that Labels Human Pluripotent Stem Cells Reviewed International journal
Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi
CELL REPORTS 6 ( 6 ) 1165 - 1174 2014.3
-
Fluorescent indicator displacement assay of ligands targeting 10 microRNA precursors Reviewed International journal
Asako Murata, Yasue Harada, Takeo Fukuzumi, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY 21 ( 22 ) 7101 - 7106 2013.11
-
Xanthone derivatives as potential inhibitors of miRNA processing by human Dicer: Targeting secondary structures of pre-miRNA by small molecules Reviewed International journal
Asako Murata, Takeo Fukuzumi, Shiori Umemoto, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23 ( 1 ) 252 - 255 2013.1
-
Small-molecule fluorescent probes for specific RNA targets Reviewed International journal
Asako Murata, Shin-ichi Sato, Yoshinori Kawazoe, Motonari Uesugi
Chemical Communications 47 ( 16 ) 4712 - 4712 2011.5
-
Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin Reviewed International journal
Shin-ichi Sato, Asako Murata, Tsubasa Orihara, Takashi Shirakawa, Kiyotake Suenaga, Hideo Kigoshi, Motonari Uesugi
CHEMISTRY & BIOLOGY 18 ( 1 ) 131 - 139 2011.1
-
A machine learning approach toward generating the focused molecule library targeting CAG repeat DNA Reviewed
Qingwen Chen, Takeshi Yamada, Asako Murata, Ayako Sugai, Yasuyuki Matsushita, Kazuhiko Nakatani
Digital Discovery 3 243 - 248 2024.1
-
A New Small Molecule DoNA Binding to CAG Repeat RNA Reviewed
Qingwen Chen, Takeshi Yamada, Koichi Miyagawa, Asako Murata, Mitsuo Shoji, Kazuhiko Nakatani
Bioorganic & Medicinal Chemistry 98 117580 2023.12
-
FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD. International journal
Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Hayato Ito, Toshihiko Sugiki, Asako Murata, Akira Ishiguro, Tania Gendron, Kohji Mori, Eiichi Tokuda, Tomoya Taminato, Takuya Konno, Akihide Koyama, Yuya Kawabe, Toshihide Takeuchi, Yoshiaki Furukawa, Toshimichi Fujiwara, Manabu Ikeda, Toshiki Mizuno, Hideki Mochizuki, Hidehiro Mizusawa, Keiji Wada, Kinya Ishikawa, Osamu Onodera, Kazuhiko Nakatani, Leonard Petrucelli, Hideki Taguchi, Yoshitaka Nagai
eLife 12 2023.7
-
Inhibitory Effects of Mismatch Binding Molecules on the Repair Reaction of Uracil-Containing DNA
Anisa Ulhusna, Asako Murata, Kazuhiko Nakatani
BIOCHEMISTRY 61 2522 - 2530 2022.10
-
HT-SELEX-based identification of binding pre-miRNA hairpin-motif for small molecules Reviewed International journal
Sanjukta Mukherjee, Asako Murata, Ryoga Ishida, Ayako Sugai, Chikara Dohno, Michiaki Hamada, Sudhir Krishna, Kazuhiko Nakatani
MOLECULAR THERAPY-NUCLEIC ACIDS 27 165 - 174 2022.3
-
Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model Reviewed International journal
Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
CHEMICAL COMMUNICATIONS 58 ( 22 ) 3629 - 3632 2022.3
-
2-Amino-1,8-naphthyridine Dimer (ANP77), a High-Affinity Binder to the Internal Loops of C/CC and T/CC Sites in Double-Stranded DNA Reviewed
Bimolendu Das, Konami Nagano, Gota Kawai, Asako Murata, Kazuhiko Nakatani
JOURNAL OF ORGANIC CHEMISTRY 87 ( 1 ) 340 - 350 2021.12
-
Speeding drug discovery targeting RNAs: An iterative “RNA selection-compounds screening cycle“ for exploring RNA-small molecule pairs Reviewed International journal
36 116070 - 116070 2021.4
-
The dimeric form of 1,3-diaminoisoquinoline derivative rescued the mis-splicing of Atp2a1 and Clcn1 genes in myotonic dystrophy type 1 mouse model. Reviewed International journal
Kazuhiko Nakatani, Jun Matsumoto, Masayuki Nakamori, Tatsumasa Okamoto, Asako Murata, Chikara Dohno
Chemistry (Weinheim an der Bergstrasse, Germany) 26 ( 63 ) 14305 - 14309 2020.5
-
RT-Hpro-PCR: A MicroRNA Detection System Using a Primer with a DNA Tag Reviewed International journal
Takei Fumie, Akiyama Misaki, Murata Asako, Sugai Ayako, Nakatani Kazuhiko, Yamashita Ichiro
CHEMBIOCHEM 21 ( 4 ) 477 - 480 2019.11
-
Structural insights into synthetic ligands targeting A–A pairs in disease-related CAG RNA repeats Reviewed International journal
Mukherjee, S, Błaszczyk, L, Rypniewski, W, Falschlunger, C, Micura, R, Murata, A, Dohno, C, Nakatani, K, Kiliszek, A
47 ( 20 ) 10906 - 10913 2019.11
-
A Dimeric 2,9-Diamino-1,10-phenanthroline Derivative Improves Alternative Splicing in Myotonic Dystrophy Type 1 Cell and Mouse Models Reviewed International journal
Li Jinxing, Nakamori Masayuki, Matsumoto Jun, Murata Asako, Dohno Chikara, Kiliszek Agnieszka, Taylor Katarzyna, Sobczak Krzysztof, Nakatani Kazuhiko
CHEMISTRY-A EUROPEAN JOURNAL 24 ( 68 ) 18115 - 18122 2018.12
-
Synthesis of Naphthyridine Dimers with Conformational Restriction and Binding to DNA and RNA Reviewed International journal
Kazuhiko Nakatani, Nozomi Natsuhara, Yuki Mori, Sanjukta Mukherjee, Bimolendu Das, Asako Murata
CHEMISTRY-AN ASIAN JOURNAL 12 ( 23 ) 3077 - 3087 2017.12
-
Synthetic ligand promotes gene expression by affecting GC sequence in promoter Reviewed International journal
Saki Matsumoto, Kei Iida, Asako Murata, Masatsugu Denawa, Masatoshi Hagiwara, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27 ( 15 ) 3391 - 3394 2017.8
-
A Ligand That Targets CUG Trinucleotide Repeats Reviewed International journal
Jinxing Li, Jun Matsumoto, Li-Ping Bai, Asako Murata, Chikara Dohno, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL 22 ( 42 ) 14881 - 14889 2016.10
-
Naphthyridine-Benzoazaquinolone: Evaluation of a Tricyclic System for the Binding to (CAG)(n) Repeat DNA and RNA Reviewed International journal
Jinxing Li, Akihiro Sakata, Hanping He, Li-Ping Bai, Asako Murata, Chikara Dohno, Kazuhiko Nakatani
CHEMISTRY-AN ASIAN JOURNAL 11 ( 13 ) 1971 - 1981 2016.7
-
Synthesis of 8-Substituted Adenine and Adenosine Libraries and the Binding to pre-miR-29a Reviewed International journal
Takeo Fukuzumi, Haruo Aikawa, Yasue Harada, Ayako Sugai, Asako Murata, Kazuhiko Nakatani
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 87 ( 9 ) 1013 - 1015 2014.9
-
Formation of a Ligand- Assisted Complex of Two RNA Hairpin Loops Reviewed International journal
Changfeng Hong, Takahiro Otabe, Saki Matsumoto, Chikara Dohno, Asako Murata, Masaki Hagihara, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL 20 ( 18 ) 5282 - 5287 2014.4
-
In vitro selection of RNA aptamers for a small-molecule dye Invited International journal
Asako Murata, Shin-Ichi Sato
Methods in Molecular Biology 1111 17 - 28 2014.1
-
Ligand-inducible formation of RNA pseudoknot Reviewed International journal
Saki Matsumoto, Changfeng Hong, Takahiro Otabe, Asako Murata, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23 ( 12 ) 3539 - 3541 2013.6
-
Structure-Activity Studies on the Fluorescent Indicator in a Displacement Assay for the Screening of Small Molecules Binding to RNA Reviewed International journal
Shiori Umemoto, Seongwang Im, Jinhua Zhang, Masaki Hagihara, Asako Murata, Yasue Harada, Takeo Fukuzumi, Takahiro Wazaki, Shin-ichi Sasaoka, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL 18 ( 32 ) 9999 - 10008 2012.8
-
10 海洋天然物オーリライドの標的タンパク質決定(口頭発表の部)
佐藤 慎一, 村田 亜沙子, 折原 翼, 白川 貴詩, 末永 聖武, 木越 英夫, 上杉 志成
天然有機化合物討論会講演要旨集 ( 53 ) 55 - 60 2011.9
-
Biochemical Target Isolation for Novices: Affinity-Based Strategies Reviewed International journal
Shin-ichi Sato, Asako Murata, Takashi Shirakawa, Motonari Uesugi
CHEMISTRY & BIOLOGY 17 ( 6 ) 616 - 623 2010.6
-
Synthesis of a novel ester analog of nucleic acids bearing a serine backbone Reviewed International journal
Asako Murata, Takeshi Wada
Bioorganic and Medicinal Chemistry Letters 16 ( 11 ) 2933 - 2936 2006.6
-
A novel linker for solid-phase synthesis cleavable under neutral conditions Reviewed International journal
Asako Murata, Takeshi Wada
Tetrahedron Letters 47 ( 13 ) 2147 - 2150 2006.3
Presentations
-
Exploring Target RNA Motifs for Small Molecules: Approach Using Dicer-Mediated Cleavage of Pre-miRNA-Like Library Invited
Asia 3 Roundtable on Nucleic Acids 2023 2023.11
-
Interaction between a small molecule, NA, and an RNA with the ACG/AUA internal loop International conference
Aina Fujiwara, Qingwen Chen, Asako Murata, Kazuhiko Nakatani, Gota Kawai
2023.11
-
Machine learning assisted classification of small molecules targeting CAG repeat DNA International conference
Qingwen Chen, Takeshi Yamada, Asako Murata, Yasuyuki Matsushita, Kazuhiko Nakatani
-
A Fluorescence Probe ANP77 for Sensing RNA Internal Loops and Their Binding Molecules International conference
Bimolendu Das, Asako Murata, Kazuhiko Nakatani
-
A rapid method for obtaining the interacting pairs of RNA-small molecule and its statistical analysis International conference
Yusuke Takashima, Asako Murata, Ayako Sugai, Kazuhiko Nakatani
-
Evaluation of the effect of small-molecule binding to mRNA on ribosomal frameshifting in SARS-CoV-2 International conference
Asako Murata, Hiyori Fujii, Risa Anami, Ayako Sugai, Kazuhiko Nakatani
-
Comprehensive analysis of small molecule-target RNA pairs toward profiling small-molecule binders of RNA Invited
Asako Murata, Yusuke Takashima, Ayumu Asai, Kazuhiko Nakatani
-
RNAを標的とする低分子の探索と応用 Invited
村田亜沙子
核酸化学若手フォーラム2021
-
Comprehensive Analysis of Dicer Substrates by High-Throughput Sequencing Identified New Target RNA Motifs for Small Molecules Invited
Asako Murata, Yusuke Takashima, Kei Iida, Ayako Sugai, Masatoshi Hagiwara, Kazuhiko Nakatani
-
小分子による–1リボソーマルフレームシフト誘起とタンパク質の輸送・局在制御への応用 Invited
村田亜沙子, 松本咲, 洪昌峰, 中谷和彦
第38回分子生物学会年会 第88回日本生化学会 合同大会
-
RNAの構造・機能を制御する小分子化合物の開発 Invited
村田亜沙子
日本化学会第94春季年会
-
Fluorescent indicator displacement assay for the discovery of RNA-binding ligands Invited
Asako Murata, Yasue Harada, Takeo Fukuzumi, Shiori Umemoto, Seongwang Im, Masaki Hagihara, Kazuhiko Nakatani
-
Evaluation of APOBEC-catalyzed cytosine deamination for the repeat DNAs with binding small molecules binding International conference
Luyan Zhang, Tomonori Shibata, Asako Murata, Kazuhiko Nakatani
2023.11
-
Inhibition of the Activity of Base Excision Repair Enzymes by Mismatch Binding Ligand Binding to Uracil-containing DNA International conference
Anisa Ulhusna, Asako Murata, Kazuhiko Nakatani
-
Evaluation of APOBEC-catalyzed cytosine deamination for the repeat DNAs International conference
Luyan Zhang, Tomonori Shibata, Asako Murata, Kazuhiko Nakatani
-
The binding motif of naphthyridine-azaquinolone dimer (NAD) in CAG-repeat RNA
Qingwen Chen, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
-
Modulation of APOBEC-catalyzed cytosine deamination by a small molecule binding to DNA
Luyan Zhang, Asako Murata, Kazuhiko Nakatani
-
Using machine learning to classify and extract features of small-molecule libraries targeting DNA and RNA International conference
Qingwen Chen, Yasuyuki Matsushita, Asako Murata, Takeshi Yamada, Ayako Sugai, Kazuhiko Nakatani
The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem2021)
-
Exploration and Identification for Small-molecules RNA binding motif by Dicer cleavage reaction and high throughput sequencing International conference
Yusuke Takashima, Asako Murata, Kazuhiko Nakatani
The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem2021)
-
Regulation of circular RNA biogenesis using nucleic acid binding small molecule in cellular environment International conference
Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem2021)
-
qPCR-based Screening Methods for Small Molecules that Modulate Dicer-mediated pre-miR-182/31/30d Processing International conference
Muhammad Nurrohman Sidiq, Asako Murata, Kazuhiko Nakatani
-
An RNA internal loop of C, U and A/CC motifs specific fluorescence probe ANP77 International conference
Bimolendu Das, Asako Murata, and Kazuhiko Nakatani
-
Cell-based screening of chemical libraries for small molecules that target SARS-CoV-2 frameshifting signal International conference
Risa Anami, Asako Murata, Kazuhiko Nakatani
-
Computer-aided classification of small molecules targeting CAG-repeat DNA International conference
Qingwen Chen, Asako Murata, Takeshi Yamada, Ayako Sugai, Yasuyuki Matsushita, Kazuhiko Nakatani
-
Development of Exploration Method and Informatics analysis for small molecule-RNA pairs. International conference
Yusuke Takashima, Asako Murata, Kei Iida, Masatoshi Hagiwara, Kazuhiko Nakatani
-
Effect of Guanine-guanine Mismatch Binding Ligand on Repair Enzymes' reactions in vitro International conference
Anisa Ul'Husna, Asako Murata, Kazuhiko Nakatani
-
Identification of small molecules that can bind to the SARS-CoV-2 frameshifting signal by SPR-based screening of chemical libraries International conference
Hiyori Fujii, Asako Murata, Kazuhiko Nakatani
-
Modulation of cytosine deamination catalyzed by Deoxycytidine Deaminase APOBEC by binding of small molecule to DNA International conference
Luyan Zhang, Asako Murata, Kazuhiko Nakatani
-
Regulation of circular RNA biogenesis via nucleic acid binding small molecule in cells International conference
Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
-
Regulation of circRNA expression in cell via RNA binding small molecule International conference
Takeshi Yamada, Lu Ni, Asako Murata, Kazuhiko Nakatani
IS3NA-IRT virtual symposium 2021
-
Machine learning-based classification in small molecules targeting CAG-repeat DNA
Qingwen Chen, Yasuyuki Matsushita, Asako Murata, Takeshi Yamada, Ayako Sugai, Kazuhiko Nakatani
-
Screening of small molecules that interfere dicer-mediated processing of pre-miR-182/31/30d
Muhammad Nurrohman Sidiq, Asako Murata, Kazuhiko Nakatani
-
Synthesis and the properties of naphthyridine-azaquinolone dimer (NAD) tatgeting CAG-repeat RNA
Qingwen Chen, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
-
Cell-basedスクリーニングによる SARS-CoV-2のフレームシフトシグナルを標的とする小分子の探索
阿南梨紗, 村田亜沙子, 中谷和彦
日本化学会第101春季年会
-
Dicer切断産物のハイスループットシーケンシングによる RNA-小分子結合モチーフの同定
高島裕介, 村田亜沙子, 中谷和彦
日本化学会第101春季年会
-
Regulation of circular RNA biogenesis via RNA binding small molecule
Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
-
SARS-CoV-2フレームシフトシグナルを標的とする低分子化合物の表面プラズモン共鳴(SPR)アッセイによるスクリーニング
藤井陽和, 村田亜沙子, 中谷和彦
日本化学会第101春季年会
-
Synthesis and the properties of NA Dimer
Qingwen Chen, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
-
Dicer切断反応を指標としたRNA結合分子標的配列の網羅的解析
髙島 裕介, 村田 亜沙子, 中谷和彦
日本化学会第100春季年会
-
Controlling -1 ribosomal frameshifting by small molecules in cells International conference
Asako Murata, Saki Matsumoto, Neva Caliskan, Marina V. Rodnina, Kazuhiko Nakatani
The 23rd SANKEN INTERNATIONAL SYMPOSIUM
-
Kinetic analysis of the inhibitory effect of BzDANP on Dicer cleavage of pre-miR-136 International conference
Asako Murata, Takahiro Otabe, Konami Nagano, Gota Kawai, Ayako Sugai, Kazuhiko Nakatani
The Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019)
-
Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats International conference
Sanjukta Mukherjee, Leszek Blaszczyk, Wojciech Rypniewski, Christoph Falschlunger, Ronald Micura, Asako Murata, Chikara Dohno, Kazuhiko Nakatani, Agnieszka Kiliszek
The 24th Annual Meeting of the RNA Society (RNA 2019)
-
Exploration of RNA sequences in pre-miRNA affecting the efficiency of Dicer cleavage reactions by the small molecules binding International conference
Yusuke Takashima, Asako Murata, Kazuhiko Nakatani
The 24th Annual Meeting of the RNA Society (RNA 2019)
-
Dicer切断を阻害するRNA結合分子標的配列の網羅的解析
高島裕介, 村田亜沙子, 中谷和彦
日本化学会第99春季年会
-
Synthetic small molecule-stabilized RNA pseudoknot as an activator for –1 ribosomal frameshifting International conference
第45回国際核酸化学シンポジウム
-
Development of Isoquinoline Ligand Binding to r(CUG) Repeats International conference
Jun Matsumoto, Jinxing Li, Masayuki Nakamori, Asako Murata, Chikara Dohno, Kazuhiko Nakatani
-
Development of Isoquinoline Ligand Binding to r(CUG) Repeats International conference
Jun Matsumoto, Jinxing Li, Asako Murata, Chikara Dohno, Kazuhiko Nakatani
XXIII International Round Table on Nucleosides, Nucleotides and Nucleic acids (IRT2018)
-
Rational design of CUG repeat binging molecule targeting Myotonic Dystrophy type 1
Jun Matsumoto, Jinxing Li, Asako Murata, Chikara Dohno, Kazuhiko Nakatani
-
Novel isoquinoline derivatives that inhibit MBNL1-CUG repeat interaction in Myotonic Dystrophy type1 International conference
Jun Matsumoto, Jinxing Li, Asako Murata, Chikara Dohno, Kazuhiko Nakatani
-
A Novel Riboswitch Strategy by Utilize Mismatch Binding Ligand (MBL)
-
Designing small molecules targeting CUG repeats causing Myotonic Dystrophy type 1 International conference
Jinxing Li, Jun Matsumoto, Bai Li-Ping, Asako Murata, Chikara Dohno, Kazuhiko Nakatani
The 22nd Annual Meeting of the RNA Society (RNA2017)
-
In vitro selection of pre-miR-29a loop mutant against the cyclic mismatch binding ligand (CMBL) International conference
Sanjukta Mukherjee, Asako Murata, Kazuhiko Nakatani
-
小分子化合物によるマイクロRNA生成阻害の速度論的解析
小田部尭広, 村田亜沙子, 中谷和彦
日本ケミカルバイオロジー学会 第11回年会
-
CAGリピートDNAおよびRNAを標的とした ナフチリジンーアザキノロン誘導体の開発と 転写および翻訳への阻害効果
阪田彬裕, 村田亜沙子, 李金星, 松本咲, Li-ping BAI, 堂野主税, 小比賀聡, 中谷和彦
日本薬学会第136年会
-
Ligand-inducible –1 ribosomal frameshifting in the cells
松本咲, 村田亜沙子, 中谷和彦
日本化学会第96春季年会
-
SPR-based in vitro selection of pre-miRNA loop mutant molecules that bind to the restrained naphthyridine dimer International conference
Yuki Mori, Yue Di, Ayako Sugai, Asako Murata, Kazuhiko Nakatani
The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem2015)
-
A small-molecule inhibitor of pre-miR-29 maturation International conference
Asako Murata, Takahiro Otabe, Jinhua Zhang, Kazuhiko Nakatani
The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem2015)
-
Analysis of binding of naphthyridine-azaquinolone derivatives to CAG repeats RNA International conference
Akihiro Sakata, Jinxing Li, Hanping He, Asako Murata, Chikara Dohno, Satoshi Obika, Kazuhiko Nakatani
The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem2015)
-
CAGリピートRNAを標的としたナフチリジン-アザキノロン誘導体の機能評価
阪田彬裕, 村田亜沙子, 李金星, 松本咲, Li-ping BAI, 堂野主税, 小比賀聡, 中谷和彦
日本核酸医薬学会第１回年会
-
小分子誘起型–1リボソームフレームシフトによる遺伝子発現制御システムの開発
松本咲, 村田亜沙子, 中谷和彦
「細胞を創る」研究会
-
Regulation of gene expression by ligand-inducible –1 ribosomal frameshifting International conference
-
Synthesis and Binding Property of Naphthyridine-Azaquinolone Derivatives Targeting (CAG)n Repeat RNA International conference
Akihiro Sakata, Jinxing Li, Hanping He, Li-ping Bai, Asako Murata, Chikara Dohno, Satoshi Obika, Kazuhiko Nakatani
-
Small molecule-Loop Interaction that interferes the maturation on process of pre-miRNA by Dicer International conference
Yuki Mori, Yue Di, Ayako Sugai, Asako Murata, Kazuhiko Nakatani
-
CAGリピートDNAおよびRNAとナフチリジンーアザキノロン誘導体とのSPRによる結合評価
阪田 彬裕, 李 金星, Hanping He, Li-ping Bai, 村田 亜沙子, 堂野 主税, 小比賀 聡, 中谷和彦
-
マイクロRNA前駆体結合分子の探索
相川春夫, 福澄岳雄, 原田恭枝, 須貝亜矢子, 村田亜沙子, 中谷和彦
日本ケミカルバイオロジー学会 第10回年会
-
Regulation of gene expression by ligand-inducible –1 ribosomal frameshifting International conference
-
In vitro selection of pre-miRNA loop mutant molecules that bind to the restrained naphthyridine dimer International conference
Asako Murata, Yuki Mori, Yue Di, Ayako Sugai, Kazuhiko Nakatani
The 20th Annual Meeting of the RNA Society (RNA2015)
-
小分子で制御するリボソームフレームシフトを用いた遺伝子発現制御
松本咲, 村田亜沙子, 洪昌峰, 中谷和彦
日本化学会第95春季年会
-
BzDANPによるRNAプロセシング阻害の速度論的解析
小田部尭広, 村田亜沙子, 中谷和彦
日本化学会第95春季年会
-
RNA結合性小分子の創成を指向したエンタルピー駆動型分子の設計と合成
夏原望, 邸玥, Sanjukta Mukherjee, 村田亜沙子, 中谷和彦
日本化学会第95春季年会
-
SPRを用いたin vitro selectionによるRND(the restrained naphthyridine dimer)結合性RNAアプタマーの探索
森友紀, 邸玥, 須貝亜矢子, 李金星, 小田部尭広, 相川春夫, 村田亜沙子, 中谷和彦
日本化学会第95春季年会
-
Synthesis of circular mismatch binding ligands and their binding properties to DNA and RNA
Sanjukta Mukherjee, Nozomi Natsuhara, Yuki, Mori, Asako Murata, Kazuhiko Nakatani
-
小分子とトリヌクレオチドリピートDNAおよびRNAとのSPRによる結合評価
阪田彬裕, 李金星, 何漢平, 小比賀聡, 村田亜沙子, 中谷和彦
日本薬学会第135年会
-
Suppression of miR-29a maturation by synthetic ligand International conference
Takahiro Otabe, Jinxin Li, Asako Murata, Kazuhiko Nakatani
-
In vitro selection of pre-miR-29a loop mutant library against the restrained naphthyridine dimer International conference
Yuki Mori, Yue Di, Ayako Sugai, Takahiro Otabe, Jinxin Li, Haruo Aikawa, Asako Murata, Kazuhiko Nakatani
-
Regulation of –1ribosomal frameshifting by ligand-induced RNA pseudoknot formation International conference
-
小分子によるリボソームフレームシフトの制御
松本咲, 村田亜沙子, 洪昌峰, 中谷和彦
日本ケミカルバイオロジー学会 第9回年会
-
8位アリール置換型アデニン誘導体の合成とpre-miR-29aに対する結合評価
相川春夫, 福澄岳雄, 原田恭枝, 須貝亜矢子, 村田亜沙子, 中谷和彦
日本ケミカルバイオロジー学会 第9回年会
-
小分子によるmiR-29a成熟過程の阻害
小田部尭広, 村田亜沙子, 武井史恵, 中谷和彦
日本ケミカルバイオロジー学会 第9回年会
-
Synthesis and Evaluation of 8-substituted Adenine Derivatives as RNA Binding Molecules International conference
Haruo Aikawa, Takeo Fukuzumi, Asako Murata, Yasue Harada, Kazuhiko Nakatani
The 19th Annual Meeting of the RNA Society (RNA2014 )
-
配座を制限したナフチリジン誘導体の合成と核酸への結合評価
松本惇, 邸玥, 李金星, 津田哲哉, 村田亜沙子, 中谷和彦
日本化学会第94春季年会
-
核酸に結合する小分子のエンタルピー駆動型分子設計と合成
夏原望, 邸玥, 津田哲哉, 村田亜沙子, 中谷和彦
日本化学会第94春季年会
-
小分子によるマイクロRNA前駆体のプロセシング阻害
小田部尭広, 村田亜沙子, 武井史恵, 中谷和彦
日本化学会第94春季年会
-
小分子によるRNAシュードノット構造の形成とフレームシフトの制御への応用
松本咲, 洪昌峰, 村田亜沙子, 中谷和彦
日本化学会第94春季年会
-
Regulation of Ribosomal Frameshifting by Ligand-inducible Formation of RNA Pseudoknot International conference
Saki Matsumoto, Asako Murata, Changfeng Hong, Kazuhiko Nakatani
The 17th SANKEN international Symposium 2013/ The 12th SANKEN Nanotechnology Symposium
-
Synthesis of RNA bulge binding small molecule and application to inhibitor of Dicer cleavage reaction International conference
Takahiro Otabe, Asako Murata, Fumie Takei, Kazuhiko Nakatani
The 1st Osaka University - EPFL International Symposium
-
Development of potential small-molecule inhibitors of pre-miRNA processing International conference
Asako Murata, Ayako Sugai, Yasue Harada, Takahiro Otabe, Takeo Fukuzumi, Kazuhiko Nakatani
The 1st Osaka University - EPFL International Symposium
-
Synthesis of the restrained naphthyridine dimer and the exploration for binding RNA by in vitro selection International conference
Yue Di, Takahiro Otabe, Jinxing Li, Asako Murata, Kazuhiko Nakatani
-
Inhibition of hairpin RNA processing by Dicer using RNA-binding small molecules International conference
Asako Murata, Ayako Sugai, Izumi Kohyama, Chikara Dohno, Kazuhiko Nakatani
Technologies for Medical Diagonosis and Therapy (G4 Meeting)
-
小分子で誘起されたRNAシュードノット構造によるフレームシフト機構の制御
松本咲, 洪昌峰, 村田亜沙子, 中谷和彦
日本ケミカルバイオロジー学会 第8回年会
-
Translational regulation by ligand-inducible formation of RNA pseudoknot International conference
Saki Matsumoto, Changfeng Hong, Asako Murata, Kazuhiko Nakatani
The 18th Annual Meeting of the RNA Society (RNA2013)
-
Suppression of miR-29a maturation by ligand binding International conference
Takahiro Otabe, Asako Murata, Fumie Takei, Kazuhiko Nakatani
The 18th Annual Meeting of the RNA Society (RNA2013)
-
Targeting secondary structures of pre-miRNA by small molecules : Development of potential inhibitors of pre-miRNA processing International conference
Asako Murata, Ayako Sugai, Takeo Fukuzumi, Shiori Umemoto, Chikara Dohno, Kazuhiko Nakatani
The 18th Annual Meeting of the RNA Society (RNA2013)
-
RNA結合性化合物を用いたマイクロRNA前駆体プロセシングの調節
村田亜沙子, 福澄岳雄, 梅本詩織, 神山いづみ, 堂野主税, 中谷和彦
日本化学会第93春季年会
-
G-Gミスマッチ結合性リガンドで誘起されるシュードノット構造を用いた遺伝発現制御システムの開発
松本咲, 洪昌峰, 村田亜沙子, 中谷和彦
日本化学会第93春季年会
-
RNAに結合する小分子のエンタルピー駆動型分子設計と合成
夏原望, 邸玥, 津田哲哉, 村田亜沙子, 中谷和彦
日本化学会第93春季年会
-
RNAに結合する小分子のエントロピー駆動型分子設計と合成
邸玥, 李金星, 津田哲哉, 村田亜沙子, 中谷和彦
日本化学会第93春季年会
-
RNAバルジ結合性小分子の合成とDicer切断反応の阻害剤としての利用
小田部尭広, 村田亜沙子, 武井史恵, 中谷和彦
日本化学会第93春季年会
-
Translation regulation of gene expression by small molecule-induced pseudoknot formation International conference
Saki Matsumoto, Changfeng Hong, Asako Murata, Kazuhiko Nakatani
-
Synthesis of Small Molecule Library for pre-miRNA Secondary Structures International conference
Takeo Fukuzumi, Asako Murata, Yasue Harada, Kazuhiko Nakatani
The 12th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-12)
-
Synthesis of Small Molecule Library for pre-miRNA Secondary Structures International conference
Takeo Fukuzumi, Asako Murata, Yasue Harada, Kazuhiko Nakatani
The 17th Annual Meeting of the RNA Society (RNA 2012)
-
High-throughput Screening of Chemical Libraries for the Discovery of RNA-binding Compounds International conference
Asako Murata, Yasue Harada, Takeo Fukuzumi, Shiori Umemoto, Seongwang Im, Masaki Hagihara, Kazuhiko Nakatani
The 17th Annual Meeting of the RNA Society (RNA 2012)
-
大規模化合物ライブラリーのスクリーニングによる，RNA結合性化合物の探索
村田亜沙子, 原田恭枝, 福澄岳雄, 梅本詩織, 任仙光, 萩原正規, 中谷和彦
日本化学会第92春季年会
-
RNAを標的とする創薬を指向した小分子ライブラリーの合成
福澄岳雄, 村田亜沙子, 原田恭枝, 中谷和彦
日本化学会第92春季年会
-
Evaluation of Xanthone and Thioxanthone Derivatives as Fluorescent Displacement Assay Indicator Based on Their Structure-Binding Studies to RNA International conference
Shiori Umemoto, Seongwang Im, Jinhua Zhang, Masaki Hagihara, Asako Murata, Yasue Harada, Takeo Fukuzumi, Takahiro Wazaki, Shinichi Sasaoka, Kazuhiko Nakatani
-
キサントン誘導体のRNA 小分子間相互作用を検出するディスプレイスメントアッセイ指示薬としての評価
梅本詩織, 任仙光, 村田亜沙子, 福澄岳雄, 原田恭枝, 笹岡眞一, 和崎隆博, 中谷和彦
第５回バイオ関連化学シンポジウム
-
Development of a method for detecting small molecule-miRNA interactions
Asako Murata, Yasue Harada, Takeo Fukuzumi, Shiori Umemoto, Seongwang Im, Masaki Hagihara, Kazuhiko Nakatani
The 16th Annual Meeting of the RNA Society (RNA2011)
-
マイクロＲＮＡ-低分子化合物の相互作用を検出するアッセイ法の開発
村田亜沙子, 原田恭枝, 福澄岳雄, 梅本詩織, 任仙光, 萩原正規, 中谷和彦
日本化学会第91春季年会
-
RNAを標的とする小分子ライブラリーの合成
福澄岳雄, 村田亜沙子, 原田恭枝, 任仙光, 中谷和彦
日本化学会第91春季年会
-
Small molecule-based FRET probes for specific RNA targets International conference
Asako Murata, Shinichi Sato, Yoshinori Kawazoe, Motonari Uesugi
The 5th Japan-Korea Chemical Biology Symposium
-
中性条件下切り出し可能なリンカーを用いたセリン骨格を有する新規核酸類縁ポリエステルの固相合成
村田亜沙子, 西郷和彦, 和田猛
日本化学会第86春季年会
-
中性条件下切り出し可能なリンカーを用いたセリン骨格を有する新規核酸類縁ポリエステルの固相合成
村田亜沙子, 西郷和彦, 和田猛
第42回ペプチド討論会
-
中性条件下切り出し可能なリンカーを用いたセリン骨格を有する新規核酸類縁ポリエステルの固相合成
村田亜沙子, 西郷和彦, 和田猛
日本化学会第85春季年会
-
セリン骨格を有する新規核酸類縁ポリエステルの固相合成
和田猛, 村田亜沙子, 常山俊和, 西郷和彦
第40回ペプチド討論会
-
セリン骨格を有する新規核酸類縁ポリエステルの固相合成
和田猛, 村田亜沙子, 常山俊和, 西郷和彦
日本化学会第83春季年会
MISC
-
次世代を担う女性研究者 マイクロRNA前駆体を標的とする低分子化合物の探索研究
村田亜沙子
化学工業 2016.4
-
アカデミア創薬研究の今を知る《注目の標的からの創薬展開》6.顕在化した創薬標的マイクロRNA(miRNA)
村田亜沙子, 中谷和彦
実験医学 2014.2
-
生理活性物質による創薬標的同定のコツ
佐藤慎一, 村田亜沙子, 白川貴詩, 上杉志成
実験医学別冊 創薬研究のためのタンパク質・プロテオミクス解析 2010.7
-
ケミカルジェネティクス:化学が教えてくれる生命機能 海洋天然物のケミカルジェネティクス
佐藤慎一, 村田亜沙子, 上杉志成
細胞工学 2009.4
-
iPS細胞誕生後 iPS細胞作製を効率化する化合物
村田亜沙子, 上杉志成
現代化学 2008.10
-
Identification of the Cardiac Beta-Adrenergic Receptor Protein: Solubilization and Purification by Affinity Chromatography
2007.10
-
ゲノムを臨床につなげる薬の世界 生物医学研究を加速するケミカルゲノミクス
村田亜沙子, 佐藤慎一, 上杉志成, 上杉志成
最新医学 2007.9
Industrial property rights
| Patent | Number of applications: 1 | Number of registrations: 1 |
| Utility model | Number of applications: 0 | Number of registrations: 0 |
| Design | Number of applications: 0 | Number of registrations: 0 |
| Trademark | Number of applications: 0 | Number of registrations: 0 |
Professional Memberships
-
The Japana Society of Nucleic Acids Chemistry
-
Japan Society for Chemical Biology
-
The Chemical Society of Japan
Academic Activities
-
Organizing committee International contribution
The 17th SANKEN international Symposium 2013/The 12th SANKEN Nanotechnology Symposium （ Japan ） 2014.1
Research Projects
-
低分子化合物-RNA相互作用の迅速スクリーニング法とAIを活用した相互作用予測モデル構築
2021.7 - 2023.6
九州大学（日本）
Authorship：Principal investigator
ＲＮＡが次世代の創薬標的として注目されている。しかし、ＲＮＡを標的とした低分子創薬研究はほとんど進んでいない。これは、低分子とそれが結合するＲＮＡ、すなわち「低分子化合物－ＲＮＡぺア」の少なさに起因して、ＲＮＡを標的とする低分子の分子設計指針が未整備であるためである。本事業では、これを解決する技術として、技術Ａ：「低分子化合物−ＲＮＡペア」データ収集のための迅速スクリーニング法、および、技術Ｂ：ＲＮＡ標的低分子デザインのための「低分子化合物−ＲＮＡペア」予測法を開発する。
-
低分子化合物－RNAペアの網羅的探索手法の確立と獲得ビッグデータの情報科学解析
2021.4 - 2025.3
九州大学（日本）
Authorship：Principal investigator
RNAが次世代の創薬標的として注目を集めている。RNAの働きが細胞の機能維持調節や疾患などに関わることが分かってきたことが背景にある。しかし、RNAを標的とした低分子創薬研究にはボトルネックがある。1) 低分子化合物-RNAペアの具体例が極めて少なく、2) RNAに結合する 低分子化合物の設計指針が不足していることである。この課題を解決し、RNA標的低分子創薬研究を加速するために、本研究では「酵素Dicerに よるRNA切断反応と次世代シーケンサーを利用した低分子化合物-RNAペアの網羅的探索手法」を確立、低分子化合物-RNAペアのビッグデータ獲 得とデータ科学・情報科学的解析を行う。
-
低分子が誘起する新奇RNA立体構造の実証
2021.4 - 2024.3
九州大学（日本）
Authorship：Principal investigator
本研究は、低分子で誘起される新奇RNA立体構造の実証を目的とする。本研究の目的達成のために、低分子NAと標的RNAとの結合評価、および、種々の構造解析手法を用いたNA-標的RNA複合体の立体構造解析を行う。さらに、低分子NAで誘起される新奇RNA立体構造のRNA編集反応における反応活性制御への応用を検討する。
-
RNA標的のケモインフォマティクス
2021.4 - 2024.3
九州大学（日本）
Authorship：Principal investigator
RNAの機能不全が種々の疾患に関わることが分かっており、RNAは次世代の創薬標的として注目されている。しかしRNAを標的とした低分子創薬はほとんど進んでいない。その理由として、RNAに結合する低分子と分子設計指針の少なさが挙げられる。本研究では、低分子-RNAペア（低分子とそれが結合するRNA）の網羅的探索法を開発し、低分子-RNAペアのビックデータ解析により、RNA標的薬の設計指針を獲得する。
-
RNA標的のケモインフォマティクス
2021 - 2027
科学技術振興機構（JST）創発的研究支援事業
Authorship：Principal investigator Grant type：Contract research
-
低分子化合物－RNAペアの網羅的探索手法の確立と獲得ビッグデータの情報科学解析
Grant number：21H02079 2021 - 2024
日本学術振興会 科学研究費助成事業 基盤研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
-
低分子が誘起する新奇RNA立体構造の実証
Grant number：21K19050 2021 - 2023
日本学術振興会 科学研究費助成事業 挑戦的研究（萌芽）
Authorship：Principal investigator Grant type：Scientific research funding
-
低分子化合物-RNA相互作用の迅速スクリーニング法とAIを活用した相互作用予測モデル構築
2021 - 2023
新エネルギー・産業技術総合開発機構（NEDO）官民による若手研究者発掘支援事業（マッチングサポートフェーズ）
Authorship：Principal investigator Grant type：Contract research
-
小分子で駆動する－１リボソームフレームシフトとタンパク質の輸送局在制御への応用
Grant number：18K05355 2018 - 2020
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
-
－１リボソーマルフレームシフトによる細胞内タンパク質の輸送・局在制御
Grant number：15K01820 2015 - 2018
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
-
リピート結合分子をプローブとしたトリヌクレオチドリピート病の化学生物学研究
Grant number：26000007 2014 - 2018
日本学術振興会 科学研究費助成事業 特別推進研究
Authorship：Coinvestigator(s) Grant type：Scientific research funding
-
小分子化合物によるマイクロRNA生成効率の調節
Grant number：25750393 2013 - 2015
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
-
８位置換プリン化合物ライブラリーの合成とリボスイッチリエンジニアリング
Grant number：23241073 2011 - 2014
日本学術振興会 科学研究費助成事業 基盤研究(A)
Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid) Grant type：Scientific research funding
-
非内在性マイクロＲＮＡの創成と遺伝子発現制御
Grant number：23710270 2011 - 2012
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
Educational Activities
-
Nucleic acids play a crucial role as vital biomolecules for storing and transmitting genetic information. Among them, RNA has gained significant attention as a promising target for drug discovery, given its diverse functions, roles, and involvement in various diseases. We focus on imparting knowledge and expertise in chemical biology, chemistry, and life sciences, with a specific emphasis on nucleic acids. Through in-depth analysis on small molecules targeting nucleic acids and their interactions, we aim to foster a comprehensive understanding of these biomolecules. By incorporating a chemical perspective into the realm of life sciences, we can effectively unravel the functions of biomolecules and their cellular roles. Ultimately, we strives to cultivate researchers capable of conducting interdisciplinary studies and pioneering novel fields of research.
Class subject
-
核酸化学
2023.10 - 2023.12 Fall quarter
-
基幹教育セミナー
2023.6 - 2023.8 Summer quarter
-
総合理工学修士実験
2023.4 - 2024.3 Full year
-
総合理工学修士演習
2023.4 - 2024.3 Full year
-
総合理工学修士演習
2023.4 - 2024.3 Full year